The impact of host genetic variation on susceptibility and pathology
Lead Research Organisation:
University of Edinburgh
Department Name: The Roslin Institute
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
In this theme, we aim to pursue genetic variation underlying disease prevalence. By combining resistance data with genome mapping techniques we are able to define loci associated with resistance to a very wide range of infections in production animals. Genetic variation can impact upon every stage of infection from initial entry to the nature and resolution of pathology and subsequent memory responses. Each pathogen-host combination offers new challenges. Targets for study are prioritised on the basis of economic importance/impact and clear evidence of heritable resistance. The aim in each study is to link genotype to phenotype (e.g. variation in an innate immune response; difference in resistance to a pathogen) in a predictive manner. We will focus on (1) poultry infection by Salmonella and Campylobacter as sources of human infection. Some S. enterica serovars as well as avian pathogenic E. coli (APEC) also threaten poultry welfare and exert a substantial economic and welfare burden owing to their ability to migrate to systemic sites, causing fowl typhoid or colibacillosis respectively. (2) Mycobacterial infections of cattle and sheep.
Planned Impact
unavailable
Organisations
- University of Edinburgh (Lead Research Organisation)
- Medical Research Council (MRC) (Collaboration)
- Agrocampus Ouest (Collaboration)
- Government of Canada (Collaboration)
- Friedrich Loeffler Institute (Collaboration)
- Arizona State University (Collaboration)
- Centre for Genomic Regulation (CRG) (Collaboration)
- ANIMAL AND PLANT HEALTH AGENCY (Collaboration)
- EMBL European Bioinformatics Institute (EMBL - EBI) (Collaboration)
- University Libre Bruxelles (Université Libre de Bruxelles ULB) (Collaboration)
- Oregon State University (Collaboration)
- Royal Veterinary College (RVC) (Collaboration)
- THE PIRBRIGHT INSTITUTE (Collaboration)
- Swedish University of Agricultural Sciences (Collaboration)
- University of Delaware (Collaboration)
- UNIVERSITY OF EAST ANGLIA (Collaboration)
- Wageningen University & Research (Collaboration)
- Utrecht University (Collaboration)
- Hungarian Academy of Sciences (MTA) (Collaboration)
- HARVARD UNIVERSITY (Collaboration)
- Animal Health Service (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- WorldFish (Collaboration)
- Konkuk University (Collaboration)
- National Food Chain Safety Office (Collaboration)
- National Veterinary Institute (Collaboration)
- Animal and Plant Quarantine Agency (Collaboration)
- Weizmann Institute of Science (Collaboration)
- Erasmus MC (Collaboration)
- University of Glasgow (Collaboration)
- Moredun Research Institute (Collaboration)
- Wellcome Trust (Collaboration)
- Iowa State University (Collaboration)
- Aviagen Group (Collaboration)
- French National Institute of Agricultural Research (Collaboration)
- U.S. Department of Agriculture USDA (Collaboration)
- Experimental Zooprophylactic Institute of the Venezie (Collaboration)
- University of Leipzig (Collaboration)
- Rothamsted Research (Collaboration)
- Kenya Agriculture & Livestock Research Organization (KALRO) (Collaboration)
- Fonds de la Recherche Scientifique (Collaboration)
- International Livestock Research Institute (ILRI) (Collaboration)
- UNIVERSITY OF NOTTINGHAM (Collaboration)
- Sheep Improved Genetics Ltd (Collaboration)
- Scotland's Rural College (Collaboration)
- University of Arkansas (Collaboration)
- Hokkaido University (Collaboration)
- Centers for Disease Control and Prevention (CDC) (Collaboration)
- Universidade de São Paulo (Collaboration)
- US Geological Survey (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- AGRI-FOOD AND BIOSCIENCES INSTITUTE (Collaboration)
- University of California, Davis (Collaboration)
- National Institute of Allergy and Infectious Diseases (NIAID) (Collaboration)
- Animal Health Research Institute (Collaboration)
- Benchmark Holdings (Collaboration)
- National Institutes of Health (NIH) (Collaboration)
- Chinese Academy of Agricultural Sciences (Collaboration)
People |
ORCID iD |
| David Gally (Principal Investigator) |
Publications
Abbas AH
(2018)
The Structure of a Conserved Telomeric Region Associated with Variant Antigen Loci in the Blood Parasite Trypanosoma congolense.
in Genome biology and evolution
Alber A
(2019)
Dose-dependent differential resistance of inbred chicken lines to avian pathogenic Escherichia coli challenge.
in Avian pathology : journal of the W.V.P.A
Alfituri O
(2018)
Effects of host-derived chemokines on the motility and viability of Trypanosoma brucei
in Parasite Immunology
Baillie JK
(2018)
Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease.
in PLoS computational biology
Banos G
(2017)
Genetic evaluation for bovine tuberculosis resistance in dairy cattle.
in Journal of dairy science
Banos G
(2017)
The genomic architecture of mastitis resistance in dairy sheep.
in BMC genomics
Bermingham ML
(2014)
Genome-wide association study identifies novel loci associated with resistance to bovine tuberculosis.
in Heredity
Bishop S
(2014)
Genomics and disease resistance studies in livestock
in Livestock Science
| Title | MOESM3 of Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes |
| Description | Additional file 3: Figure S1. Principal component analysis results for Horro (red triangles) and Jarso (blue squares) chickens. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2016 |
| URL | https://springernature.figshare.com/articles/figure/MOESM3_of_Genome-wide_association_studies_of_imm... |
| Title | MOESM3 of Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes |
| Description | Additional file 3: Figure S1. Principal component analysis results for Horro (red triangles) and Jarso (blue squares) chickens. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2016 |
| URL | https://springernature.figshare.com/articles/figure/MOESM3_of_Genome-wide_association_studies_of_imm... |
| Description | In this theme, our main aim was to pursue host genetic variation underlying disease prevalence in farm animals, focusing on identification of loci and genes responsible for variation in innate responses to endemic pathogens of livestock species and poultry, and the gene variants that lead to disease resistance. The work brought together scientists across several disciplines including molecular and quantitative genetics, bioinformatics, genomics, transcriptomics, immunology, pathology and pathogen biology. By combining phenotyptic infectious disease resistance data with genome mapping techniques we are able to define loci associated with resistance to a very wide range of infections in production animals including cattle, sheep, and chickens. Genetic variation can impact upon every stage of infection from initial entry to the nature and resolution of pathology and subsequent memory responses. Each pathogen-host combination offers new challenges. Targets for study were prioritised on the basis of economic importance/impact and clear evidence of heritable resistance. The aim in each study within this theme was to link genotype to phenotype (e.g. variation in an innate immune response; difference in resistance or tolerance to a pathogen) in a predictive manner. In general, the studies involved the identification of quantitative trait loci (QTL) by linking genotypes to phenotypes. Genotypes were determined through an integrated post-genomics approach investigating various types of genomic variation including SNPs and copy number variants (CNV) across the genome as well as SNPs in candidate genes. Many of these were resources developed at Edinburgh Genomics and in ISP1). The phenotypes involved careful selection of appropriate data that was related to an appropriate immune response, correlate of protection, pathology or mortality identified through experimental challenge and/or ISPs 1 and 4. Data were also collected from the field (for example statutory skin test data and abattoir for bovine tuberculosis, or industry data). Identification of candidate genes and causal variants was aided by knowledge of gene function, pathway data and annotation generated in theme 1. Knowledge gained by determining the way in which variation alters disease outcome can be translated into a strategy for disease mitigation, most often through selective breeding. We focused on (1) poultry infection by Salmonella and Campylobacter as sources of human infection. Some S. enterica serovars as well as avian pathogenic E. coli (APEC) also threaten poultry welfare and exert a substantial economic and welfare burden owing to their ability to migrate to systemic sites, causing fowl typhoid or colibacillosis respectively. (2) Mycobacterial infections of cattle and sheep, some of which have a zoonotic potential. Highlights: • Copy number variants (CNVs) are being identified as underpinning variation in disease resistance in many species and a survey among chicken breeds has found many CNVs, some of which are associated with chicken lines selected for resistance. A 600K SNP chip has also been developed as a further resource for chicken disease resistance traits • Campylobacter intestinal colonisation in chickens has been defined as a complex trait in broiler bird lines and several QTLs investigated using expression and pathway analysis to identify potential candidate genes. Campylobacter resistance has been associated with the avian MHC, and innate and acquired immune responses. • Variation in antibody response was associated to genotypic variation (SNPs) in indigenous Ethiopian chickens to various pathogens causing major production losses. These included bacteria (Salmonella gallinarum and Pasteurella multocida causal agents of fowl typhoid and fowl cholera respectively) and viruses (Infectious Bursal Disease Virus and Marek's Disease Virus). Genetic variation in resistance to the avian apicomplexan parasite Eimeria and to cestode parasitism was also observed. These results indicate that selective breeding for disease resistance could provide a safe and sustainable strategy for chickens in countries such as Ethiopia. • The sheep nematode Teladorsagia circumcincta is a common pathogen of sheep and represents with important economic impact in many countries of the world, including the UK. Control is by anthelmintics but there are issues with resistance. No vaccine is available. Several immune-associated candidate genes have been associated with resistance and susceptibility to this nematode using transcriptomics of the mucosal tissue of infected sheep. These include the T Cell Transcription Factor and IL-23. GATA3 and IL17RB are associated with enhanced resistance to this nematode. • Mycobacterium avium subspecies paratuberculosis is a widespread gastrointestinal pathogen of sheep in the UK and elsewhere, and causes two distinct forms of disease, multibacillary and paucibacillary. Transcript variants of various cytokine transcription factors, cytokines and cytokine receptors were associated independently with the two forms of disease. The results suggested that the pathology associated with multibacillary paratuberculosis is induced by a Th2 biased response whereas the pathology associated with the paucibacillary is determined by Th1 and Th17 biased responses. These studies have identified various candidate genes associated with these types of T cell response and suggest that the two forms of disease may be under distinct genetic control. • Bovine tuberculosis (bTB) is caused by the pathogen Mycobacterium bovis and despite statutory control measures remains an important issue in the UK and many other countries. Spill over into wildlife means there is no simple solution. Vaccination is not currently a viable option. Genetic control through selective breeding could provide an alternative strategy. Earlier work demonstrated genetically determined variation in risk of bTB infection. Three GWAS studies have been conducted. In collaboration with AFBI, Northern Ireland, two case-control studies, have shown that there are two pathological outcomes following M. bovis infection, which appear to be under separate genetic control, and therefore distinct mechanisms. With this data we also showed that genomic prediction for bTB risk was feasible. A third study in collaboration with SRUC, using estimated breeding values for bTB risk in UK sires has confirmed that the genetic architecture of bTB risk is polygenic with many loci of small effect within the population of UK cattle. Together with SRUC, national evaluations for bTB resistance in the Holstein dairy breed have been conducted, and the information in the form of an index (TB advantage) is offered to farmers through the auspices of AHDB. Whole genome sequence of high and low risk sires has been conducted to help identify causal loci and improve genomic prediction for bTB risk. |
| Exploitation Route | We continue to work with the livestock industry to advance genetic approaches to improve disease resistance in farmed animal species. As precise genetic modification methods for farmed animals become more reliable and efficient it opens up the possibility to generate production animals that are resistant to specific diseases. A primary aim moving forward is to: (1) define the most significant infectious diseases for which specific genetic alterations could make a significant impact in terms of reducing disease burden and improving animal welfare; these currently including African Swine Fever, PRRS and Flu. (2) provide a scientific understanding of host resilience to disease across different breeds of production animals so that cross breeding can allow introgression of desirable resilience traits. |
| Sectors | Agriculture Food and Drink Pharmaceuticals and Medical Biotechnology |
| Description | The Roslin continues to be an internationally-recognised centre for research into the genetics of production animals with an emphasis on resilience to infectious diseases. In the new ISP 'Control of Infectious Diseases' (2017-2022), our infection control research across viruses, bacteria and parasites has been combined as from a host perspective many of the breeding and genetic modification approaches are shared. In this theme (linked also to theme 1), impact outside of basic knowledge and training includes; (1) The instigation of TB advantage which was developed with SRUC and is offered to farmers through the auspices of AHDB. This allows national evaluations for bTB resistance in the Holstein dairy breed in the form of an index so that TB resilience is one factor that can be selected when breeding characteristics are considered. (2) Under LINK and core funding, a large campylobacter GWAS study has been carried out in the progeny of crosses of inbred lines that were known to differ in resistance (Psifidi et al. 2016) and in 3000 commercial broilers. A heritable component to resistance can be selected without negatively impacting other production traits of commercial importance. Some QTL are shared between the inbred and broiler studies and BBSRC support has helped leverage £450k at 100% FEC from Scottish Government to take this forward. The aim is for selection of commercial birds that are more resistance to Campylobacter and have less pathogen load in terms of likelihood of human infection. |
| First Year Of Impact | 2014 |
| Sector | Agriculture, Food and Drink |
| Impact Types | Societal Economic |
| Description | Academy of Medical Sciences's "Preparing for a challenging winter 2020/21" report |
| Geographic Reach | National |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| URL | https://www.gov.uk/government/publications/covid-19-preparing-for-a-challenging-winter-202021-7-july... |
| Description | Advancing European Aquaculture by Genome Functional Annotation |
| Amount | € 6,000,000 (EUR) |
| Funding ID | 817923 |
| Organisation | European Union |
| Sector | Public |
| Country | European Union (EU) |
| Start | 04/2019 |
| End | 04/2022 |
| Description | Animal Health Research Club (ARC) |
| Amount | £839,502 (GBP) |
| Funding ID | BB/L004054/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2014 |
| End | 09/2017 |
| Description | Animal health and disease and veterinary immune reagents collaboration with USDA |
| Amount | £381,777 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2015 |
| End | 08/2018 |
| Description | BBSRC ANIWHA call 2 |
| Amount | £428,690 (GBP) |
| Funding ID | BB/M028305/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 09/2018 |
| Description | BBSRC Industrial Partnering Award |
| Amount | £1,500,000 (GBP) |
| Funding ID | BB/P022049/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2017 |
| End | 09/2020 |
| Description | BBSRC Industrial Partnering Award Scheme |
| Amount | £516,308 (GBP) |
| Funding ID | BB/J015296/1 (Role of AKT1 & SIVA1 in resistance to avian salmonellosis) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2012 |
| End | 09/2015 |
| Description | BBSRC Responsive Mode |
| Amount | £1,640,000 (GBP) |
| Funding ID | BB/V009818/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2021 |
| End | 08/2025 |
| Description | BBSRC Responsive Mode |
| Amount | £900,000 (GBP) |
| Funding ID | BB/R008612/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2021 |
| Description | BBSRC-DBT joint call for proposals Farmed Animal Disease and Health (FADH) |
| Amount | £428,822 (GBP) |
| Funding ID | BB/L004739/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2014 |
| End | 09/2017 |
| Description | BBSRC-NIFA |
| Amount | £417,191 (GBP) |
| Funding ID | BB/M028208/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 09/2018 |
| Description | BBSRC-NIFA scheme for UK-US collaboration on animal diseases |
| Amount | £800,000 (GBP) |
| Funding ID | BB/M028208/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 09/2018 |
| Description | BBSRC-SFI-Tackling a multi-host pathogen problem - phylodynamic analyses of the epidemiology of M. bovis in Britain and Ireland |
| Amount | £448,073 (GBP) |
| Funding ID | BB/P010598/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 09/2020 |
| Description | Bilateral BBSRC-SFI: Tackling a multi-host pathogen problem - phylodynamic analyses of the epidemiology of M. bovis in Britain and Ireland |
| Amount | £440,743 (GBP) |
| Funding ID | BB/P010598/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 04/2020 |
| Description | Center for Tropical Livestock Health and Genetics |
| Amount | £15,000,000 (GBP) |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 02/2017 |
| End | 03/2020 |
| Description | Development of genetic improvement tools to support tropical dairy and poultry small holder livestock systems (CTLGH 2.0) |
| Amount | £12,013,168 (GBP) |
| Funding ID | INV-040641 |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 07/2022 |
| End | 08/2027 |
| Description | Direct funding from Industry (Hendrix Genetics) - Genome editing for resistance to IPNV in salmon |
| Amount | £180,892 (GBP) |
| Organisation | Hendrix Genetics |
| Sector | Private |
| Country | Netherlands |
| Start | 06/2016 |
| End | 03/2019 |
| Description | EPIC: Centre of Expertise on Animal Disease Outbreaks |
| Amount | £10,000,000 (GBP) |
| Organisation | Government of Scotland |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 04/2021 |
| Description | European Commission H2020-INFRAIA-2016-1 |
| Amount | € 10,000,000 (EUR) |
| Funding ID | EU project 731014 |
| Organisation | European Commission H2020 |
| Sector | Public |
| Country | Belgium |
| Start | 03/2017 |
| End | 03/2022 |
| Description | Funding for genotyping from Hy-Line International |
| Amount | £30,000 (GBP) |
| Organisation | HyLine |
| Sector | Private |
| Country | United States |
| Start | |
| Description | Genome editing for resistance to viral disease in rainbow trout |
| Amount | £161,786 (GBP) |
| Organisation | Hendrix Genetics |
| Sector | Private |
| Country | Netherlands |
| Start | 11/2020 |
| End | 02/2022 |
| Description | Genomic and nutritional innovations for genetically superior farmed fish to improve efficiency in European aquaculture |
| Amount | € 6,149,963 (EUR) |
| Funding ID | 818367 |
| Organisation | European Union |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2019 |
| End | 12/2022 |
| Description | Identification of interferon stimulated genes that control Toxoplasma in pig macrophages |
| Amount | £588,626 (GBP) |
| Funding ID | BB/W014807/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2022 |
| End | 06/2025 |
| Description | Scottish Aquaculture Innovation Centre |
| Amount | £1,000,000 (GBP) |
| Organisation | Scottish Aquaculture Innovation Centre |
| Sector | Multiple |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2020 |
| Description | Scottish Government RESAS initiative |
| Amount | £900,000 (GBP) |
| Organisation | Government of Scotland |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2019 |
| Description | The Houghton Trust, Small Project Grant Scheme |
| Amount | £10,000 (GBP) |
| Organisation | The Houghton Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | open call |
| Amount | £379,303 (GBP) |
| Funding ID | BB/L004003/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2014 |
| End | 04/2017 |
| Description | open call |
| Amount | £632,704 (GBP) |
| Funding ID | BB/L00478X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2014 |
| End | 06/2017 |
| Title | Archive of tissues & data from genome-wide association studies on Campylobacter resistance. |
| Description | Archive of materials from commercial broilers of defined 50K SNP genotype and Campylobacter colonisation phenotype, including DNA for further typing, caecal mucosa for transcriptome analysis and gut microbiota. The same exists for the progeny of crosses between inbred lines 6 and N used for genome-wide association studies to map QTL for C. jejuni resistance. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | QTL for Campylobacter resistance in the chicken, as published in 2016 and in preparation for publication. Owing to the source of material from commercial birds, supply of materials to third party users will require a Material Transfer Agreement and the consent of Aviagen Ltd. We have since been able to retrieve caecal mucosa from the archive to conduct RNAseq analysis on chickens at the extreme of colonisation phenotype, and have supplied DNA from the populations studied to collaborators for MHC typing. |
| Title | Data from the study Fine-mapping host genetic variation underlying outcomes to Mycobacterium bovis infection in dairy cows |
| Description | This dataset derives from a study on the host genetic variation in resistance to bovine tuberculosis (bTB) in dairy cattle and relates to genotyping of cattle for bovine tuberculosis. . In total, 1,966 Holstein-Friesian dairy cows were genotyped 777,962 single nucleotide polymorphisms (SNPs). After quality control (for specific details see publication) 538,231 autosomal SNPs remained for all animals genotyped. This is case-control data in that phenotypes are binary (0,1), based on outcomes to diagnostic tests. Data files are from the study: Wilkinson et al 2017. Fine-mapping host genetic variation underlying outcomes to Mycobacterium bovis infection in dairy cows. BMC Genomics 18:477. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | The results suggest some differing underlying genetics governing observed versus non-observed pathology for bTB infected animals, supporting the notion of a bTB infection spectrum. The implications of complex genetic control of bTB susceptibility may need to be considered in disease control. |
| URL | https://link.springer.com/article/10.1186/s12864-017-3836-x |
| Title | MOESM10 of Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes |
| Description | Additional file 10: Tables S9 and S10. List of selected candidate genes for immune, disease and productivity traits studied in Jarso (Table S9) and Horro (Table S10) chickens. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/MOESM10_of_Genome-wide_association_studies_of_i... |
| Title | MOESM10 of Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes |
| Description | Additional file 10: Tables S9 and S10. List of selected candidate genes for immune, disease and productivity traits studied in Jarso (Table S9) and Horro (Table S10) chickens. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/MOESM10_of_Genome-wide_association_studies_of_i... |
| Title | MOESM6 of Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes |
| Description | Additional file 6: Tables S6 and S7. List of genes located in the candidate genomic regions for the Jarso (Table S6) and Horro (Table S7) chickens. Candidate regions were defined 100 kb upstream and downstream of the significant SNPs. Gene lists for infectious bursal disease virus (IBDV) antibody titre, Mareksâ disease virus (MDV) antibody titre, Salmonella enterica serovar Galinarum (SG) antibody titre, Pasteurella multocida (PM) antibody titre, Eimeria parasitism resistance, cestodes parasitism resistance, body weight and body condition score (BCS) are shown. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/MOESM6_of_Genome-wide_association_studies_of_im... |
| Title | MOESM6 of Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes |
| Description | Additional file 6: Tables S6 and S7. List of genes located in the candidate genomic regions for the Jarso (Table S6) and Horro (Table S7) chickens. Candidate regions were defined 100 kb upstream and downstream of the significant SNPs. Gene lists for infectious bursal disease virus (IBDV) antibody titre, Mareksâ disease virus (MDV) antibody titre, Salmonella enterica serovar Galinarum (SG) antibody titre, Pasteurella multocida (PM) antibody titre, Eimeria parasitism resistance, cestodes parasitism resistance, body weight and body condition score (BCS) are shown. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/MOESM6_of_Genome-wide_association_studies_of_im... |
| Title | MOESM9 of Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes |
| Description | Additional file 9: Table S8. Functional annotation clustering analysis using DAVID software for Jarso and Horro chickens. The most highly represented functional gene clusters located in the candidate genomic regions for infectious bursal disease virus (IBDV) antibody titre, Salmonella enterica serovar Galinarum (SG) antibody titre, Pasteurella multosida (PM) antibody titre, Eimeria parasitism resistance, cestodes parasitism resistance and body condition score (BCS). |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/MOESM9_of_Genome-wide_association_studies_of_im... |
| Title | MOESM9 of Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes |
| Description | Additional file 9: Table S8. Functional annotation clustering analysis using DAVID software for Jarso and Horro chickens. The most highly represented functional gene clusters located in the candidate genomic regions for infectious bursal disease virus (IBDV) antibody titre, Salmonella enterica serovar Galinarum (SG) antibody titre, Pasteurella multosida (PM) antibody titre, Eimeria parasitism resistance, cestodes parasitism resistance and body condition score (BCS). |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/MOESM9_of_Genome-wide_association_studies_of_im... |
| Title | TB Project Genotyping Results |
| Description | Raw SNP data and ancillary files from genome wide association studies on bovine tuberculosis BBSRC funded projects: CEDFAS initiative grants BB/E018386/1 and BB/E018335/1 and 2; Animal Health Research Club grant BB/L004054/1; Institute Strategic Programme Grants (ISP3 Innate Immunity & Endemic Disease) [BB/J004227/1], (ISP1 Analysis and Prediction in Complex Animal Systems) [BB/J004235/1] and (ISP2 Control of Infectious Diseases) [BB/P013740/1]. Abstract Holstein-Friesian raw SNP data. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Dataset related to publication: 5. Wilkinson, S., Bishop, S.C. Allen, A.R., McBride, S.H., Skuce, R.A., Bermingham, M., Woolliams, J.A. and Glass, E.J. (2017) Fine-mapping host genetic variation underlying outcomes to Mycobacterium bovis infection in dairy cows. BMC Genomics, 18: 477. Dataset linked to Bermingham et al, 2014, Genome-wide association study identifies novel loci associated with resistance to bovine tuberculosis. Heredity, 112, 543-551. |
| URL | https://www.research.ed.ac.uk/portal/en/datasets/liz-glass-tb-project-genotyping-results(7aa9bca3-a0... |
| Description | BBSRC-FAPESP tick resistance in cattle consortium |
| Organisation | Rothamsted Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The Roslin Institute, University of Edinburgh partner contributes expertise in quantitative genetics, genome-wide association studies, including the genetics of disease resistance in farm animal species. The team also provides access to the expertise and capabilities of the University of Edinburgh's genomics facility (Edinburgh Genomics). |
| Collaborator Contribution | The Rothamsted partner contributes expertise in biochemistry and analysis of semio-chemical involved in the attraction of insects. The Sao Paulo partner provides essential expertise and access to biological samples (sebum, DNA) and phenotypic data. |
| Impact | Joint BBSRC-FAPESP grant funding to study the genetics of resistance to ticks in cattle. The partnership combines expertise in genetics, and biochemistry. |
| Start Year | 2010 |
| Description | BBSRC-FAPESP tick resistance in cattle consortium |
| Organisation | Universidade de São Paulo |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | The Roslin Institute, University of Edinburgh partner contributes expertise in quantitative genetics, genome-wide association studies, including the genetics of disease resistance in farm animal species. The team also provides access to the expertise and capabilities of the University of Edinburgh's genomics facility (Edinburgh Genomics). |
| Collaborator Contribution | The Rothamsted partner contributes expertise in biochemistry and analysis of semio-chemical involved in the attraction of insects. The Sao Paulo partner provides essential expertise and access to biological samples (sebum, DNA) and phenotypic data. |
| Impact | Joint BBSRC-FAPESP grant funding to study the genetics of resistance to ticks in cattle. The partnership combines expertise in genetics, and biochemistry. |
| Start Year | 2010 |
| Description | Bovine Tuberculosis sequencing and modelling collaboration |
| Organisation | University of Glasgow |
| Department | MRC - University of Glasgow Centre for Virus Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Help with analysis of bovine tuberculois sequences with Phylodynamics computational techniques |
| Collaborator Contribution | Lead of Tb project, collection of bovine Tb sequences and other modelling expertise |
| Impact | Papers resulting: Trewby et al (2016) "Use of bacterial whole-genome sequencing to investigate local persistence and spread in bovine tuberculosis" Epidemics, Vol 14 March 2016, Pages 26-35 Crispbell (2017) "Using whole genome sequencing to investigate transmission in a multi-host system: bovine tuberculosis in New Zealand" BMC Genomics 2017 Feb 16;18(1):180 Successful grant application due to start April 2017: Bilateral BBSRC-SFI: Tackling a multi-host pathogen problem - phylodynamic analyses of the epidemiology of M. bovis in Britain and Ireland PI: Professor Rowland Kao:University of Glasgow BB/P010598/1 |
| Start Year | 2014 |
| Description | Centre for Tropical Livestock Genetics and Health (CTLGH) |
| Organisation | International Livestock Research Institute (ILRI) |
| Country | Kenya |
| Sector | Charity/Non Profit |
| PI Contribution | Research contribution to the CTLGH result framework. |
| Collaborator Contribution | Research links and collaboration with its member partners in the UK and Africa. |
| Impact | No output to report yet. |
| Start Year | 2017 |
| Description | Collaboration relating to genetics of bovine tuberculosis |
| Organisation | Agri-Food and Biosciences Institute |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Secured two rounds of grant funding from BBSRC. Expertise in genome wide association studies. |
| Collaborator Contribution | Epidemiology of bovine TB and data and samples from cases and controls to genotype and analyse. |
| Impact | Multi-disciplinary: AFBI: epidemiology; bovine TB expertise; data analysis; surveillance Roslin: genetics; GWAS; genotyping; immunogenetics; innate immunity; host-pathogen interactions Outputs: See BB/E018335/1 and BB/E018335/2; BB/L004054/1; BB/L004119/1 Publications: Bermingham ML, Handel IG, Glass EJ, Woolliams JA, de Clare Bronsvoort BM, McBride SH..Bishop SC. (2015). Hui and Walter's latent-class model extended to estimate diagnostic test properties from surveillance data: a latent model for latent data. Scientific reports, pp. 11861 Bermingham ML, Bishop SC, Woolliams JA, Pong-Wong R, Allen AR, McBride SH..Glass EJ. (2014). Genome-wide association study identifies novel loci associated with resistance to bovine tuberculosis. Heredity, 112 (5), pp. 543-51 Tsairidou, S. Woolliams, J.A., Allen, A.R., Skuce, R.A., McBride, S.H., Wright, D.M., Bermingham, M.L., Pong-Wong, R., Matika, O., McDowell, S.W., Glass, E.J., Bishop, S.C. Genomic prediction for tuberculosis resistance in dairy cattle (2014) PLoS ONE, 9, e96728. doi:10.1371 Tsairidou S, Woolliams JA, Allen AR, Skuce RA, McBride SH, Wright DM..Bishop SC. (2014). Genomic prediction for tuberculosis resistance in dairy cattle. PloS one, 9 (5), pp. e96728 |
| Start Year | 2006 |
| Description | Collaboration relating to genomic selection for resistance to bovine tuberculosis |
| Organisation | Scotland's Rural College |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Genotyping and analysing additional animals and phenotypes related to bovine TB. Combining data sets from different sources to conduct a meta-analysis. Sequencing high and low risk sires. Novel SNP discovery. |
| Collaborator Contribution | R and D to underpin development of sustainable systems of livestock production. Responsible for UK implementation of genomic breeding values in dairy cattle. Statistics, genetic and genomic evaluations for bovine TB. Implementation of pedigree based evaluations and genomic evaluations for bovine TB into the routine systems of evaluation and dissemination to industry. Publication: Banos G, Winters M, Mrode R, Mitchell A, Bishop S, Woolliams J..Coffey M. (2017). Genetic evaluation for bovine tuberculosis resistance in dairy cattle. Journal of Dairy Science, 100 (2), pp. 1272-1281 |
| Impact | Outputs: See BB/L004119/1 and BB/L004054/1. |
| Start Year | 2014 |
| Description | Collaboration with Aviagen Ltd |
| Organisation | Aviagen Group |
| Country | United States |
| Sector | Private |
| PI Contribution | The project was funded via the BBSRC LINK scheme and involved a close collaboration with Aviagen Ltd, part or the Erich Wesjohann Group and a major global breeder of poultry. In broad terms, the project sought to define the genetic basis of avian resistance to Campylobacter colonisation. This involved genome-wide association studies using the progeny of crosses of inbred lines that differ in heritable resistance to Campylobacter (specifically backcross and advanced inter-cross populations derived from lines 6 and N), and identified quantitative trait loci (QTL) associated with resistance (Psifidi et al. 2016). The project also involved a genome-wide association study using over 3000 Aviagen broilers in a simulated field context. High quality genotypes and Campylobacter colonisation phenotypes were identified for 2750 broilers and QTL associated with resistance were identified, two of which were shared with the study using inbred lines (manuscript in preparation). Studies to validate QTL and understand how they exert their effect are ongoing with core funding from the BBSRC and a grant from the Scottish Government. |
| Collaborator Contribution | As above. Aviagen provided access to its flocks and expertise, as well as costs for genotyping and validation of QTL. |
| Impact | See publications & additional funding sections of this return. By defining the genomic architecture of avian resistance to Campylobacter our studies will inform the scope to breed selectively for birds with improved control of an important zoonotic pathogen. Our studies show that a relatively modest proportion of the variation in the trait (caecal C. jejuni numbers) can be explained by bird genetics and that resistance-associated QTL are already prevalent in the commercial broiler line studied. Work is ongoing to validate the associations between QTL and Campylobacter levels, and understand how they exert their effect. There is scope for long-term societal gain from the research as chicken continues to be the primary reservoir of human campylobacteriosis. |
| Start Year | 2012 |
| Description | Collaboration with Benchmark PLC in salmon gene editing |
| Organisation | Benchmark Holdings |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | This collaboration has been to develop a successful Industrial Partnership Award proposal for BBSRC into gene editing for disease resistance in salmon. Our team have developed gene editing facilities and capability in house for salmon (cell culture and embryos), and worked together with Benchmark to codevelop the project which begins on 1 April 2018. The reference code is BB/R008612/1. |
| Collaborator Contribution | The partners are bringing substantial in kind contribution, cash contribution and expertise to the project. This includes access to samples and data from their salmon breeding programme in Norway, and access to year-round salmon gametes for gene editing experiments. |
| Impact | Outputs include the successful award of project BB/R008612/1 |
| Start Year | 2017 |
| Description | Collaboration with Dr Mark Fife at The Pirbright Institute |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I was the lead applicant on this BBSRC proposal and the postdoctoral researcher deployed on the project was responsible for delivery of stated objectives. |
| Collaborator Contribution | Dr Fife was a co-Investigator in this proposal and has played the leading role in genome-wide association studies investigating the basis of avian resistance to fowl typhoid. This has involved investigation of two naturally-occurring outbreaks for which he attracted an additional funding from Hy-Line for genotyping. |
| Impact | We have been invited to submit a manuscript to Frontiers in Genetics in Spring 2018 related to the genome-wide association studies to map quantitative trait loci for fowl typhoid resistance in commercial layers. |
| Start Year | 2011 |
| Description | Collaboration with RVC - Eimeria |
| Organisation | Royal Veterinary College (RVC) |
| Department | Pathobiology and Population Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaborative projects to explore the genetic/phenotypic basis of response to Eimeria challenge in poultry. Our expertise is in basic poultry biology and analysis of data to determine the underlying genetic basis of response. |
| Collaborator Contribution | Our partners at RVC have in depth understanding of the pathogen Eimeria and how this impacts the bird. In addition they have technical expertise in managing challenge experiments. |
| Impact | To date there has been publications and generation of significant data. |
| Start Year | 2017 |
| Description | Identifying and exploiting the molecular basis of resistance to gastrointestinal parasites |
| Organisation | Sheep Improved Genetics Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Teladorsagia circumcincta is a common parasitic nematode of the sheep abomasum, causing reduced growth in young lambs. The widespread development of anthelmintic resistant parasites has driven the need for alternative control strategies. Resistant immunity is acquired through repeated exposure to the parasite. The immune response and clinical outcome vary greatly between animals, but resistance is heritable. The aims of this project were: 1) understand how sheep respond to nematode infection; 2) understand and identify genes associated with the response; 3) identify variation within those genes which may contribute to resistance. Using an artificially infected animal model, transcriptomic analysis in resistant and susceptible lambs identified genes involved in T helper cell polarization as integral to disease outcome. T helper cell (Th)1 and Th17 activation was associated with susceptibility (low antibody, high worm numbers) while a Th2 response was associated with resistance (high antibody levels and clearance of infection). The Th cell transcription factors (GATA3, TBX21, RORC2 and RORA) were sequenced with splice variants and SNPs identified. Analysis of gene expression in the abomasal lymph node identified RORAv2 as associated with susceptibility and RORAv5 as associated with resistance. In the abomasal mucosa, GATA3 expression was linked to resistance. Expression analysis of cytokine receptors expressed by Th cells identified IL17RB and IL17RBv2 as associated with resistance in the abomasal mucosa. Analysis of the SNPs within these genes in 3 naturally infected populations identified a significant association between SNPs in IL23R with weight and FEC. This project has provided an in-depth analysis of the ovine transcriptome and identified several genes associated with the development of resistance to nematodes. |
| Collaborator Contribution | The support/sponsorship of SIG Ltd was initially essential to obtain funding for a BBSRC Industrial CASE Award. In addition, SIG Ltd were highly supportive of the work and acted as advisors on the impact of the research. They also supplied a large number of biological samples from sheep with known phenotypic characteristics in relation to gastrointestinal nematode parasite infection. |
| Impact | 1. Wilkie, H.E. (2016) Identifying and Exploiting the Molecular Basis of Resistance to Gastro-intestinal Nematodes in Sheep. PhD Thesis, University of Edinburgh. 2. Wilkie, H., S. Xu, A. G. Gossner and J. Hopkins. (2015). Variable exon usage of differentially-expressed genes associated with resistance of sheep to Teladorsagia circumcincta. Vet. Parasitol 212, 206-213. PMID: 26330386, doi:10.1016/j.vetpar.2015.08.023. 3. Wilkie, H., A. G. Gossner, S. Bishop and J. Hopkins. (2016). Variations in T cell transcription factor sequence and expression associated with resistance to the sheep nematode Teladorsagia circumcincta. PLoS ONE 11(2): e0149644. PMID: 26890074, doi:10.1371/journal.pone.0149644. 4. Wilkie. H., L. Nicol, A. G. Gossner and J. Hopkins. (2016). Mucosal expression of T cell gene variants is associated with differential resistance to Teladorsagia circumcincta. PLoS ONE 11(12): e0168194. PMID: 27973603. doi:10.1371/journal.pone.0168194. 5. Wilkie, H., V. Riggio, O. Matika, K. Watt, R. Sinclair, A. Sparks, D. Nussey, J. Pemberton, R. D. Houston and J. Hopkins. (2017). Identification of single nucleotide polymorphisms associated with growth in parasitized lambs. Vet. Parasitol. (revised, resubmitted). |
| Start Year | 2013 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | Agrocampus Ouest |
| Country | France |
| Sector | Academic/University |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | Arizona State University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | Centre for Genomic Regulation (CRG) |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | EMBL European Bioinformatics Institute (EMBL - EBI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | French National Institute of Agricultural Research |
| Department | INRA Rennes Centre |
| Country | France |
| Sector | Public |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | French National Institute of Agricultural Research |
| Department | INRA Toulouse |
| Country | France |
| Sector | Public |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | French National Institute of Agricultural Research |
| Country | France |
| Sector | Academic/University |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | Harvard University |
| Department | Harvard Medical School |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | Iowa State University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | Kenya Agriculture & Livestock Research Organization (KALRO) |
| Country | Kenya |
| Sector | Private |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | Medical Research Council (MRC) |
| Department | Medical Research Council (MRC) Centre Cambridge |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | National Institute of Allergy and Infectious Diseases (NIAID) |
| Country | United States |
| Sector | Public |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | National Institutes of Health (NIH) |
| Department | National Institute of Environmental Health Sciences |
| Country | United States |
| Sector | Public |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | Oregon State University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | Swedish University of Agricultural Sciences |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | University of Arkansas |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | University of California, Davis |
| Department | UC Davis Genome Cente |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | University of Delaware |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | University of East Anglia |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | University of Leipzig |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | University of Nottingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Avian RNA-Seq Consortium |
| Organisation | Weizmann Institute of Science |
| Country | Israel |
| Sector | Academic/University |
| PI Contribution | I organised the 6th International chick meeting, Edinburgh (2011) and also formed at that event the International Avian RNA-Seq Consortium. The purpose was to collaborate with national and international labs to pool RNA-seq data for the chicken (and other avian genomes). This data would provide a rich source of data for gene annotation of the chicken genome. This was used subsequently to annotate the chicken genes by the ENSEMBL gene annotation team, as part of our BBSRC funded work. We provided the organisation, advice for submission of data, provided early storage of data, and we provided all our data (20+ libraries). |
| Collaborator Contribution | Many labs joined (21+) and one output was a joint publication and yearly updates to chicken genome. |
| Impact | Jacqueline Smith, Bronwen L. Aken, Perry J. Blackshear, Shane C. Burgess, Amanda M. Cooksey, Dirk-Jan de Konig, Ian C. Dunn, Mario Fasold, Laure Frésard, David P. Froman, Valerie Garceau, Olivier Hanotte, Julien Häsler, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Fiona M. McCarthy, Heather A. McCormack, Stefan A. Muljo, Andrea Münsterberg, Cedric Notredame, Harry Noyes, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Frédérique Pitel, Douglas D. Rhoads, Carl J. Schmidt, Matt Schwartz, Steve M. Searle, Michael A. Skinner, Peter F. Stadler, Cliff J. Tabin, Igor Ulitsky, Ying Wang, Huaijun Zhou, David W. Burt. (2015). In: "Chicken Genes and Chromosomes, Third Report 2015 (Editors: Schmid M., Smith J., Burt D.W.). The Avian RNASeq Consortium: a community effort to annotate the chicken genome. Cytogenetic and Genome Research 145, 83-88; DOI: 10.1159/isbn.978-3-318-05569-6. |
| Start Year | 2011 |
| Description | International Livestock Research Institute, Kenya - GCRF-Impact accelerator grant. |
| Organisation | International Livestock Research Institute (ILRI) |
| Country | Kenya |
| Sector | Charity/Non Profit |
| PI Contribution | Conception and design of the experiment. High throughput RNA-sequencing data analysis. Preparation of future manuscripts and follow-on grants. |
| Collaborator Contribution | Access to and sampling of gastrointestinal nematode resistant sheep. The collaborators also contributed to the conception of the experiment and will contribute to the data analysis. |
| Impact | High resolution phenotypes of crossbred sheep resistant or susceptible to gastrointestinal nematodes. |
| Start Year | 2017 |
| Description | Molecular immunology of sheep paratuberculosis |
| Organisation | Moredun Research Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Collaborative work has investigated the host response to Mycobacterium avium subspecies paratuberculosis, the causative agent of Johne's disease, to explain the molecular basis for the development of the different pathological forms of the disease. Previous collaborative work with the Moredun Research Institute led to the hypothesis that differential T cell activation was critical for the development of paucibacillary and multibacillary paratuberculosis. Analysis of similar diseases in humans (tuberculosis and leprosy) supported this hypothesis. Consequently, initial studies focussed on the identification of cytokine receptor and transcription factor genes of sheep that, in humans and mice, are known to influence T cell polarization and tuberculosis/leprosy pathology. This was extended to identify the transcript variants of these genes. Assays were developed to allow accurate quantification of these genes in the ileo-caecal lymph node (the primary immune inductive site of paratuberculosis lesions) of pathologically-defined animals. These experiments measured the expression of specific transcript variants; linking IL23 and IL25 receptors, and the GATA3, RORC2 and RORA transcription factors, with paucibacillary and multibacillary disease. These data showed that the two disease forms were not just a result of a simple switch from Th1 to Th2 but that sheep with multibacillary disease had a broad immune dysfunction. To examine this immune dysfunction, we performed Illumina Truseq analysis on these same samples. This showed that paucibacillary and multibacillary disease are different stages of the same process. The inflammatory response of both diseases is an acute phase response (chronic inflammation) and not an acute inflammatory response. Animals with both forms of pathology also show a large increase in the expression of immunoglobulin genes. The major difference between paucibacillary and multibacillary animals is that there is a significant reduction in the expression of most genes associated with T cell function and activation. Perhaps the most surprising result was that all diseased animals showed a large reduction in the expression of transcripts associated with mast cells, and this was supported by subsequent histochemistry. |
| Collaborator Contribution | The Moredun Research Institute provided biological material from diseased sheep. These sheep were clinical cases with naturally-acquired paratuberculosis. They had been culled for clinical reasons and subjected to post-mortem examination, including a full pathological/bacteriological examination. This had been done for more than 100 animals and 18 animals were chosen for the molecular immunology studies. These included animals with defined paucibacillary (tuberculoid) and multibacillary (lepromatous) pathologies. Coolleagues were also fully involved in discussions of the data and also in editing manuscripts. |
| Impact | 1. Nicol, L., A. G. Gossner, C. Watkins, F. Chianini, R. G. Dalziel and J. Hopkins. (2016). Variations in IL-23 and IL-25 receptor gene structure, sequence and expression associated with the two disease forms of sheep paratuberculosis. Veterinary Research 47; 27. PMID: 26861902, doi: 10.1186/s13567-016-0314-4. 2 Nicol, L., H. Wilkie, A. G. Gossner, C. Watkins, R. G. Dalziel and J. Hopkins. (2016). Variations in T cell transcription factor gene structure and expression associated with the two disease forms of sheep paratuberculosis. Veterinary Research 47:83. PMID: 27530627.doi: 10.1186/s13567-016-0368-3. 3. Gossner, A. C. Watkins, F. Chianini and J Hopkins. (2017). Pathways and genes associated with immune dysfunction in sheep paratuberculosis. Scientific Reports (revision under review). |
| Start Year | 2013 |
| Description | PRRS Host Genetics Consortium |
| Organisation | Iowa State University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Genetic analysis of infectious disease data and mathematical modelling of PRRS infection dynamics; Contribution to experimental design of PRRS challenge and field experiments and sampling; |
| Collaborator Contribution | Access to data; access to statistical models; scientific advice for model assumptions |
| Impact | Joint manuscripts and publications: 1. Go N., Islam Z., Lunney J., Belloc C., Touzeau S.& Doeschl-Wilson A.B., 2017. Neutralizing antibodies prevent PRRS viremia rebound: evidence from a data-supported model of the immune response. PloS Comp. Biol. Under review 2. Lough G., Hess A., Dekkers JCM, Hess M., Kyriazakis I., Mulder H., Lunney J, Rowland BB, Doeschl-Wilson A.B. 2017. Harnessing longitudinal information to identify genetic variation in tolerance of pigs to Porcine Reproductive and Respiratory Syndrome virus. Genetics Selection Evolution. Under review 3. Lough G., Rashidi H., Kyriazakis I., Dekkers JCM, Hess AS, Hess MK, Deeb N, Kause A., Lunney J, Rowland BB, Mulder H and Doeschl-Wilson A.B. 2017. Use of multi-trait and random regression models to identify genetic variation in tolerance to Porcine Reproductive and Respiratory Syndrome virus. Genetics Selection Evolution, 49(1)37. 3. 4. Hess, A.S., Islam, Z., Hess, M.K., Rowland, R.R., Lunney, J.K., Doeschl-Wilson, A., Plastow, G.S. and Dekkers, J.C., 2016. Comparison of host genetic factors influencing pig response to infection with two North American isolates of porcine reproductive and respiratory syndrome virus. Genetics Selection Evolution, 48(1), p.1.18. 5. Islam Z.U., Bishop S.C., Savill N.J. , Rowland R.R.R., Lunney J.K., Trible B and Doeschl-Wilson A.B. 2013. Quantitative analysis of Porcine Reproductive and Respiratory Syndrome (PRRS) viremia profiles from experimental infection: a statistical modelling approach. PLoS One, DOI: 10.1371/journal.pone.0083567. ( |
| Start Year | 2012 |
| Description | Strategic research partnership with WorldFish |
| Organisation | Worldfish |
| Country | Malaysia |
| Sector | Charity/Non Profit |
| PI Contribution | A strategic research partnership has been established between Roslin and WorldFish. This partnership is initially focussed on use of advanced genetic and genomic technology to improve selective breeding of tilapia - one of the world's most important foodfish. Our contribution has included development of a research programme that builds on research performed in Atlantic salmon to inform strategies and techniques to implement genomic selection in WorldFish tilapia breeding programme. |
| Collaborator Contribution | WorldFish run a family based selective breeding programme for tilapia and will provide data and samples from this programme to inform the research. |
| Impact | This is a multidisciplinary partnership involving researchers involved in tilapia health, genetics, molecular biology and bioinformatics. |
| Start Year | 2017 |
| Description | The Evolution of Mycobacterium bovis evolution in Africa |
| Organisation | U.S. Department of Agriculture USDA |
| Country | United States |
| Sector | Public |
| PI Contribution | We have made available a collection of Mycobacterium isolates from cattle from across Africa that the BBSRC funded plus one has coordinated. |
| Collaborator Contribution | The USDA have sequenced these isolates using their WGS pipeline. |
| Impact | work is still in progress |
| Start Year | 2016 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Animal Health Research Institute |
| Country | Taiwan, Province of China |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Animal Health Service |
| Country | Netherlands |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Animal and Plant Health Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Animal and Plant Quarantine Agency |
| Country | Korea, Republic of |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Centers for Disease Control and Prevention (CDC) |
| Country | United States |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Chinese Academy of Agricultural Sciences |
| Department | Harbin Veterinary Research Institute (HVRI) |
| Country | China |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Erasmus MC |
| Department | Department of Viroscience |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Experimental Zooprophylactic Institute of the Venezie |
| Country | Italy |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Fonds de la Recherche Scientifique |
| Country | Belgium |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Friedrich Loeffler Institute |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Government of Canada |
| Department | Canadian Food Inspection Agency (CFIA) |
| Country | Canada |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Government of Canada |
| Department | Canadian Food Inspection Agency (CFIA) |
| Country | Canada |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Hokkaido University |
| Department | Graduate School of Veterinary Medicine |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Hokkaido University |
| Department | Research Center for Zoonosis Control |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Hungarian Academy of Sciences (MTA) |
| Country | Hungary |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | International Livestock Research Institute (ILRI) |
| Country | Kenya |
| Sector | Charity/Non Profit |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Konkuk University |
| Country | Korea, Republic of |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | National Food Chain Safety Office |
| Department | Veterinary Diagnostic Directorate |
| Country | Hungary |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | National Veterinary Institute |
| Country | Sweden |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | U.S. Department of Agriculture USDA |
| Department | National Wildlife Research Center |
| Country | United States |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | U.S. Department of Agriculture USDA |
| Department | Southeast Poultry Research Laboratory |
| Country | United States |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | U.S. Department of Agriculture USDA |
| Country | United States |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | US Geological Survey |
| Country | United States |
| Sector | Public |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | University Libre Bruxelles (Université Libre de Bruxelles ULB) |
| Department | Spatial Epidemiology Laboratory |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | University of Oxford |
| Department | Centre for Tropical Medicine and Global Health |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | University of Oxford |
| Department | Department of Zoology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Utrecht University |
| Department | Department of Farm Animal Health |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Wageningen University & Research |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | The Global Consortium for H5N8 and Related Influenza Viruses |
| Organisation | Wellcome Trust |
| Department | Wellcome Trust Major Overseas Programme in Ho Chi Minh City Vietnam |
| Country | Viet Nam |
| Sector | Charity/Non Profit |
| PI Contribution | I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately). |
| Collaborator Contribution | The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute. |
| Impact | Paper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852 |
| Start Year | 2014 |
| Description | University of Nottingham - genome-wide RNA interference applied to Trypanosoma congolense |
| Organisation | University of Nottingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This is a new collaboration within this project, applying a novel genome wide RNA interference screen to identifying drug mode of action and mechanisms of resistance. The project team provided input into experimental design and analysis. |
| Collaborator Contribution | The partners have developed the screen, and facilitated access to apply the screen to our biological problem of interest. Collaborators have also provided significant input into analysis and interpretation of results. |
| Impact | Identification of candidate genes in Trypanosome congolense involved in drug mode of action or drug resistance. Analysis, validation and further experiments are ongoing. |
| Start Year | 2019 |
| Description | Avian genome evolution and the origins of species diversity. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited lecture: Avian genome evolution and the origins of species diversity. In "Molecular evolution of avian species", SMBE2016, Queensland's Gold Coast, Australia, 3-7 July, 2016. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Bovine TB Resistance & Genetics Workshop; Belfast November 2016 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Following the success of the Workshop that the team ran in November 2015 in Cardiff, this was the second 2 day workshop on genetic improvement for bovine tuberculosis (bTB)resistance. The aim of the workshop was to discuss the genetics of bTB and breeding for bTB resistance between academic researchers, industry and government officials. attendees came from England, Northern Ireland and the Republic of Ireland and included representatitives from DEFRA, DAERA, AFBI, BBSRC and the Knowledge Transfer Network. The first day of the workshop discussed the current situation in England, Wales and Northern Ireland as well as Ireland; scientific advances in the genetics of bTB in dairy cattle as well as genetic evaluations for bTB resistance in UK and Ireland. The plan to sequence high and low risk sires for bTB resistance was presented. A new topic was discussed that of infectivity and the potential to combine selection for infectivity and susceptibility. The uptake of bTB resistance EBVs through AHDB as "TB Advantage" index was discussed. Future research priorities, including the potential impact of selection on economics and health and welfare of cattle in the dairy industry, potential for EBVs for bTB for beef breeds, interaction with other traits including Johne's disease and sharing of data were also discussed. The workshop further fostered dialogue between government officials, academics and industry on tackling bTB and was found to be useful and informative by all. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Bovine TB Resistance & Genetics Workshop; Cardiff November 2015 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | The project team organised a 2 day workshop on bTB resistance held in 18-19 November 2015, Cardiff, UK. The aim of the workshop was to discuss the genetics of bTB and breeding for bTB resistance between not just academic researchers, but also importantly industry and government officials. Attendees included academics from United Kingdom, Northern Ireland and the Republic of Ireland and DEFRA, AFBI and representatives from the Welsh Government, BBSRC. The first day of the workshop involved a series of presentations from academics detailing the latest research results on the genetics of bTB resistance and officials describing the current situation on bTB prevalence across parts of the UK and ROI. The second day of the workshop started with presentations on the publications of EBVs for bTB resistance followed by a round-table discussion on bTB issues. Overall, it was shown that a genetic strategy to reduce bTB prevalence is a feasible option and this message was well received and supported. Concerns on the impact of breeding for bTB resistance on response to the tuberculin skin test were discussed. In addition, there were discussions on future directions of research on bTB genetics. The workshop fostered dialogue between government officials, academics and industry on tackling bTB and was found to be useful and informative by all. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Development of New Tools for Genetic Selection for a Sustainable Poultry Industry |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a talk: Development of New Tools for Genetic Selection for a Sustainable Poultry Industry (2014), Veterinary Advances in Animal Health and Welfare Research - Impact and Opportunities, Feb 20-24, 2014, NIANP Auditorium, Adugodi, Bangalore, India |
| Year(s) Of Engagement Activity | 2014 |
| Description | Edinburgh India Institute, Inaugural conference on 15-16 May 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Gave a short talk about avian influenza BBSRC-DBT project and how it came about, joint talk with our India collaborators. Edinburgh India Institute, Inaugural conference on 15-16 May 2014. John McIntyre Conference Centre, Edinburgh. Conference theme: Innovative Engagement for Sustainable Development: the Edinburgh-India Story. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Feature for BBC2 Food Detectives programme |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Professor Stevens took part in a BBC2 Food Detectives programme which featured Campylobacter in chickens. He helped to design a survey of Campylobacter contamination in a sample of fresh chicken obtained from Scottish retailers and interpret the findings. This were close to Food Standards Agency findings, which were broadcast as part of an interview with Prof. Alice Roberts. The interview took place at The Roslin Institute and included a lay description of Campylobacter, the importance of chickens as a reservoir of infection and strategies by which consumers can protect themselves. It also highlighted BBSRC-funded work at Roslin to mitigate the problem based on genetic selection (this project) and vaccines (other BBSRC projects held by Prof. Stevens). |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.bbc.co.uk/programmes/b077rgd4 |
| Description | H5N8 bird flu press release |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press release about H5N8 bird flu study; also covered by BBC news http://www.bbc.co.uk/news/science-environment-37643894 |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.roslin.ed.ac.uk/news/2016/10/14/migration-routes-hold-key-to-bird-flu-spread-global-study... |
| Description | Immunology conference (Germany) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Oral presentation at the avian immunology research group meeting in Germany, Sept 2016. Audience included industry members post graduate students, junior and senior scientists. UK was voted to be the organisers of the next meeting in 2018 in Oxford and I will be part of the organising team. This will lead to great publicity for the funded avian immunology research funded by the RCUK. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.airg2016.vetmed.uni-muenchen.de/airg_2018/index.html |
| Description | Invited lecture at MSD-Animal Health |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited lecture at MSD-Animal Health in Boxmeer the Netherlands, with WebEx connection to all other location o MSD -AH around the world. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited talk at symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | North American PRRS symposium. Chicago, USA, Dec 2017. Novel insights about host response to PRRS from data driven mathematical models. Invited talk. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Media interest in IFN paper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Press article in WattAgNet regarding a paper describing genetic variation in immune genes in chicken lines known to be either susceptible or resistant to various viral infections: https://pubmed.ncbi.nlm.nih.gov/35739459/ |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.wattagnet.com/articles/45556-chicken-study-explores-genetic-resistance-to-viruses?v=prev... |
| Description | Membership of a guidance committee on PCV2 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Expert Group on PCV2 for DISCONTOOLS FP 7 project, funded by DG Research |
| Year(s) Of Engagement Activity | 2006,2008,2009,2011,2013,2015,2017,2019 |
| Description | New Scientist Future of Food Webinar |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Ross Houston took part in the New Scientist Future of Food and Agriculture workshop by taking part in a panel discussion on genome editing. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.newscientist.com/science-events/future-food-agriculture/ |
| Description | New tools and prospects for chicken genomics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk at Genetics Society of Australia (GSA), July 2015, University of Adelaide, Australia |
| Year(s) Of Engagement Activity | 2015 |
| Description | Past, Present and Future of Genomics in Poultry Breeding. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk: Past, Present and Future of Genomics in Poultry Breeding. 25th World's Poultry Congress, Beijing, 5-9 September, 2016. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Plenary talk |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Disease in aquaculture workshop, Universidad Autónoma de Baja California, Ensenada Mexico, October 2017. Genetic resistance and vaccination analysis on infectious disease genetics and genetic-epidemiological modelling in aquatic animals. Keynote presentation. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Plenary talk at conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary Speaker at the International veterinary Immunology Symposium, Seattle, August 2019. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Poultry Genomics: Current Status and Future Trends from Next Generation Sequencing |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a talk at the 8th International Conference on Genomics (ICG-8). Talk: Poultry Genomics: Current Status and Future Trends from Next Generation Sequencing. 29 Oct - 1 Nov 2013, Shenzhen, China. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Presentations & pitches to animal nutrition and breeding companies |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | A series of presentation to potential industrial partners who are interested in the chicken enteroid model for application as a screening tool. A range of nutrition companies are seeking an in vitro tool to screen the effects of feed additives on immune responses. Breeding companies are seeking for an in vitro tool to test resilience. Both sectors are keen to replace in vivo trials with in vitro models . |
| Year(s) Of Engagement Activity | 2021 |
| Description | Production Animal Health and Welfare Research: Impacts and Opportunities. |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk at Production Animal Health and Welfare Research: Impacts and Opportunities. 19-20 Feb, 2015, Indian Council for Agricultural Research (ICAR), New Delhi, India |
| Year(s) Of Engagement Activity | 2015 |
| Description | Public lecture entitled Confronting the Microbial Menace in Our Food'. Professor Mark Stevens |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | The inaugural lecture of Professor Mark Stevens was held on 30 October 2017 on his BBSRC-funded research to identify bacterial and host factors influencing the ability of Salmonella, Campylobacter and E. coli to colonise farm animals and cause disease. It was attended by children from local schools, members of the public, students at The Roslin Institute and wider University of Edinburgh and posted online. |
| Year(s) Of Engagement Activity | 2017,2018 |
| URL | https://media.ed.ac.uk/media/Inaugural+lectureA+Confronting+the+microbial+menace+in+our+food/1_x5k5e... |
| Description | Public lecture on Campylobacter in chickens |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Public talk on 'Chickens and the enemy within' at The Roslin Institute Open Doors Day in 2012. This highlighted the problem of Campylobacter infections in people, the role of poultry as a reservoir, and research at Roslin to control the problem via genetic selection and vaccination in poultry and to understand the molecular basis of virulence of the organism. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Summer course |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Armidale Animal Breeding Summer Course 2018: Mathematical modeling of infection dynamics in genetically diverse livestock populations Teachers: Andrea Doeschl-Wilson and Osvaldo Anacleto Dates: Monday 5 February 2018 (9am) - Thursday 8 February 2018 (4pm) Venue: University of New England, Armidale, NSW Australia; ~40 post-graduate students, academics and industrial researcher attended the workshop in modelling. Based on the positive course evaluation, the course sparked new research in the important field of mathematical modelling of infection dynamics and genetics |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://jvanderw.une.edu.au/aabc2018.htm |
| Description | TEDx Talk by Professor Helen Sang on 'Why do we need GM chickens?' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Professor Helen Sang delivered a Tedx Talk in Glasgow on 2 June 2017 on 'Why do we need GM chickens?'. The event was attended by approximately 1700 people and has been shared online with over 900 views. It highlighted the challenge of achieving global food security and the potential of BBSRC-funded research to improve poultry, including via genetic alteration. Examples for ongoing research using GM poultry in this programme were shared. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.youtube.com/watch?v=DUbqrh5otWs |
| Description | The Chicken and other Avian Genomes: new insights and opportunities for all from high throughput sequencing and bioinformatics. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk: the Chicken and other Avian Genomes: new insights and opportunities for all from high throughput sequencing and bioinformatics. In "Avian Model Systems 9: a new integrative platform", Taipei, Taiwan, 38 March to 3 April, 2016. |
| Year(s) Of Engagement Activity | 2016 |
| Description | The chicken genome 10 years on. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote lecture: chicken genome - 10 years on. Avian Model Systems - the 8th International Meeting, Cold Spring Harbour, USA, 4-8th March, 2014. CSHL Leading Strand - Keynote Lecture Series (http://theleadingstrand.cshl.edu/Course/Keynote/2014/AVIAN/150 The chicken genome 10 years on - BBSRC (http://www.bbsrc.ac.uk/news/events/1403-chicken-genome.aspx) |
| Year(s) Of Engagement Activity | 2014 |
| Description | Visit by Bill Gates and the Secretary of State for the Department of International Development |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Bill Gates and the Secretary of State for the Department of International Development (DfID; Rt Hon Penny Mordaunt) visited The Roslin Institute on 26 January 2018. This involved separate sessions with the Gates Foundation and DfID to learn about the research undertaken by the Centre for Tropical Livestock Genetics & Health (CTLGH), in which the Roslin Institute is a major partner and researchers in the Institute Strategic Programmes are heavily involved. DfID announced £4m of funding for the CTLGH, adding to £10m already received from the Gates Foundation. In the presence of the Principal of the University of Edinburgh, Bill Gates and the Rt Hon Penny Mordaunt formally opened the Global Academy for Agriculture & Food Security which will provide undergraduate and postgraduate training in sustainable agriculture. The event took place in the new Campus Innovation Building (which received BBSRC strategic funding). The University of Edinburgh press office tracked the following activity related to the visit, in which many participants in the ISPs were involved: • 109 individual articles and broadcast pieces that mentioned the University with regards to the visit, with an estimated potential reach of more than 7 million people. • Of these, more than half of the coverage mentioned one of more of the Global Academy of Agriculture & Food Security, the Centre for Tropical Livestock Genetics & Health, SEBI, the Royal (Dick) School of Veterinary Studies, Roslin or the Easter Bush Campus in addition to name checking the University. • In addition to the UK, we also attracted press coverage in the USA, France, New Zealand, China, Zimbabwe, South Africa, Botswana, Taiwan and Egypt. • Across social media, we reached more than 1.4 million people with 14k+ engagements (likes, shares, retweets etc). Of these, 99.8% were positive. • The Facebook Live streaming alone reached more than 100k people. More than 18k people have watched the video. • Our news videos have garnered more than 35k views across platforms. • We tracked a spike in traffic to the Global Academy website on the day of the visit - 1405 visits (11 times the average for the previous month). |
| Year(s) Of Engagement Activity | 2018 |
| Description | Wellcome Trust Board of Governors and Executive Board |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | The Wellcome Trust's Board of Governors and Executive Board visited Edinburgh University including the Roslin Institute on 19/20 September. The Post-doc on this grant, Samantha Wilkinson, Smaragda Tsairidou and Adrian Mwonge presented a joint poster on their work on various aspects of bovine TB host genetics, epidemiology and the detection test characteristics. |
| Year(s) Of Engagement Activity | 2016 |