National Capability Grant - National Avian Research Facility

Lead Research Organisation: University of Edinburgh
Department Name: The Roslin Institute

Abstract

This facility provides underpinning funding the National Avian Research Facility (NARF), a joint venture of The Roslin Institute (RI) and The Pirbright Institute (PI). The facility forms a national resource centre for experimental science of poultry and model avian species. The NARF, based at RI will comprise new Specified-Pathogen-Free and conventional avian facilities. This facility will provide specialist resources for avian biology research, ranging from basic developmental biology to research of direct value to the poultry breeding and production industry, and of benefit to human health through reducing food-borne zoonoses. At RI, our vision is to develop a research resource centre that will maintain and provide access to inbred and transgenic lines, transgenic and germ cell preservation technologies alongside genetic/genomic and gene expression analytical resources. This centre will be not just a unique resource centre for the UK, but a unique and world- leading centre, because of the wide range of facilities we will bring together. These resources will be available to the relevant UK research communities and also for international collaborations. NARF will benefit from input from ARK Genomics, as a centre for genomics and transcriptomics of a wide range of bird species, including inbred chicken lines, commercial poultry species and breeds and other key avian species of research interest. It will also integrate provision of other resources, for example the Chicken Gene Expression Atlas that is being developed with BBSRC funding, currently specifically to support developmental biology research. There are two components of the facility for which this NCG provides funding for: (1) support for the Transgenic Chicken Facility (TCF), including opportunities to work with the TCF to generate novel transgenic chickens and for access to material from established transgenic lines and (2) the infrastructure to maintain 8 inbred lines of chickens (although the cost of maintaining these lines will come from PI ISP/NCG funds), each of a single MHC haplotype, for studying basic immunology, vaccinology and the genetic contribution to traits of economic importance, particularly those associated with resistance and susceptibility to disease. These two aspects will also coincide in providing opportunities for generating transgenic birds in the specific genotypes of the inbred lines.

Publications

10 25 50

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Bailey IE (2014) Physical cognition: birds learn the structural efficacy of nest material. in Proceedings. Biological sciences

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Bettridge JM (2014) Infection-interactions in Ethiopian village chickens. in Preventive veterinary medicine

 
Description National Avian Research Facility NCG. Objectives of this NCG were to develop conventional and specified pathogen-free (SPF) facilities to supply inbred and transgenic poultry, develop genomic resources for birds, and to preserve genetic resources via development of a frozen aviary. Both building phases were completed on time within budget. Inbred and outbred layer lines have been re-derived to SPF status at Roslin, enabling closure of the Compton laboratory. Such lines remain valuable resources to define the genetic and immunological basis of resistance to key avian and zoonotic pathogens and underpinned substantial uplift funding. Established transgenic lines (e.g. cytoplasmicGFP and membraneGFP) were supplied to over 24 laboratories all over the world resulting in over 50 papers in the reporting period. In collaboration with ISP2, NARF also supported the production of novel transgenic lines, including MacReporter chickens, ubiquitous TdTomato for transplantation studies, lox-stop-loxGFP for CRE recombinase-activated lineage tracing and splitGFP to trace virus infection by delivery of a complementary peptide by viruses that leads to GFP fluorescence in infected cells. Genome sequence data for 46 avian species has been made publicly available via the NARF website through in-house databases, together with re-sequencing, extensive RNA-Seq, SNP genotype and copy number variation data on all the lines held. To preserve genetic resources we have further developed primordial germ cell (PGC) technology and semen-freezing methods with support from ISP2. PGCs from inbred lines, rare breeds, and commercial stock have been successfully frozen and proven to be germline competent on implantation of thawed cells into embryos. Together with ISP2, NARF has supported the development of efficient methods for mutagenesis and transgenesis in PGCs and implantation into sterile recipients. NCG funding of the NARF has supported >100 publications since 2012.
Exploitation Route The National Avian Research Facilities (NCG) continues to play a key role in our research to define the genetic and immunological basis of resistance to avian and zoonotic pathogens and in providing genome-engineered animals to study development and gene function (with ISP1 & ISP2). Many of the Avian resources developed during the NCG support continue to be maintained and used in collaborative projects within the Institute and wider in the research community (as evidenced by the extensive collaborations). The national flock of inbred lines housed within the NARF SPF unit (The Bumstead Building) provide a unique resource for the investigation of response to avian and zoonotic diseases. The facilities are imperative for continued core elements of Roslin research. Specific highlights of work supported by the NARF are the development of key transgenic lines. In transgenic MacReporter (CSF1R-reporter) chickens expression of the reporter gene provided a defined marker for chicken macrophage, monocytes and dendritic cells-lineage cells, identifying the earliest stages in the yolk sac, throughout embryonic development and in all adult tissues. Chickens lack lymph nodes and lymphoid tissues with equivalent function are difficult to visualise and isolate, which has made the isolation of cells and analysis of local immune responses especially difficult. The brightness and specificity of the CSF1R-reporter gene expression gives a unique macroscopic view of the organisation and extent of chicken lymphoid tissues, enabling simple identification of immune tissues and isolation of immune cells.The MacReporter chickens have been used extensively within the institute, and we are now in the process of developing this avian resource to make it available for wider use. Our second highlighted genetically modified line has been developed to facilitate both the development of gene edited or genetically modified chickens in addition to providing a key resource to enable the revival of cryopreserved chicken breeds. We used precision gene editing tools to produce a chicken with a mutation in the gene DDX4. When bred to homozygosity, the chicken does not produce any eggs. This sterile chicken can be used as a host recipient for the transplantation of oocytes from other breeds of chicken or modified primordial germ cells. When stem cells are transplanted into embryos from this chicken, the offspring produced will be from the stem cell host which can be either of a rare breed of chicken or genetically modified/gene edited. We have communicated these results to researchers maintaining poultry facilities in Europe and elsewhere to keep them abreast of these novel developments. In addition to the avian resources and facilities the NARF provides a defined hub for nationally-unique expertise in primordial germ cell technology and procedures for gene editing/genetic modification in poultry.
Sectors Agriculture, Food and Drink

 
Description The development of technology around the cryopreservation of avian material or "the frozen aviary" has tremendous impact scientifically but equally important non-academic impacts in terms of preservation and regeneration of rare or "at risk" avian breeds. We have developed a genetically modified chicken that can be used to revive cryopreserved chicken breeds. Using precision gene editing tools we produced a chicken with a mutation in the gene DDX4. When an individual carries two copies of the mutant DDX4 gene it does not produce any of its own eggs. However, if we introduce primordial germ cells (PGCs) from a donor rare breed to a developing DDX4 embryo, the mature female will lay eggs from the donor rare breed. In conjunction with our ability to cryopreserve PGCs we have produced methods to cryopreserve and revive rare or "at risk" avian breeds. These development have been widely reported in the UK national press. Our work with a large proportion of the major global avian breeding companies has enabled the development of tools and methodologies with the potential to complement and advance progress within commercial animal breeding programmes. These activities include the development of methods to explore the genetic basis of Avian Influenza and Salmonella Typhimurium susceptibility/resistance in collaboration with Hy-Line International; exploring methods to determine eggshell cuticle quality with Lohmann tierzucht/Aviagen Ltd "Cute-Egg, improvement of eggshell cuticle quality to reduce vertical transmission of zoonotic and pathogenic organisms"; understanding the genetic basis of campylobacter infection in broilers with Aviagen Ltd "A systems-wide approach to the control of Campylobacter in the food chain: exploiting genetic variation" and "Mapping resistance to Campylobacter in the chicken"; and understanding resistance to Eimeria infections in collaboration with Cobb-Vantress "Understanding resistance and differential vaccine responses to Eimeria in the chicken - novel biomarkers and genetic control." and "The role of interleukin-10 (IL-10) in the regulation of innate immunity in the domestic chicken". These collaborative projects have the potential to improve animal health, welfare and productivity, grow UK business and because of the scale of the international companies we collaborate with, these projects have the potential to elicit a significant impact on the global avain food safety and security.
First Year Of Impact 2014
Sector Agriculture, Food and Drink,Environment
Impact Types Societal,Economic

 
Description Member of Knowledge Transfer Network Animal Sector Advisory Board
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
URL https://ktn-uk.co.uk/
 
Description WPSA European Federation Working Group - WG3 Breeding and Genetics
Geographic Reach Europe 
Policy Influence Type Membership of a guideline committee
URL http://www.wpsa.com/index.php/breeding-and-genetics-wg-3
 
Description ANIHWA call 2: Better bone quality in laying hens
Amount £836,262 (GBP)
Funding ID BB/M028291/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 06/2015 
End 10/2018
 
Description ANIHWA call1 TURKEYWELFARE
Amount £75,281 (GBP)
Funding ID BB/L012022/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2014 
End 02/2016
 
Description Accelerating advances in animal welfare
Amount $486,594 (USD)
Funding ID 550396 
Organisation Foundation for Food and Agriculture Research 
Start 04/2018 
End 03/2022
 
Description Agri-tech Catalyst
Amount £850,000 (GBP)
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 01/2015 
End 01/2018
 
Description An Institute Strategic Support Fund (ISSF3).
Amount £35,000 (GBP)
Funding ID ISSF3 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2018 
End 03/2019
 
Description BBSRC - Responsive mode research grants
Amount £590,000 (GBP)
Funding ID BB/R003653/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 11/2017 
End 11/2020
 
Description BBSRC ANIWHA call 2
Amount £428,690 (GBP)
Funding ID BB/M028305/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2015 
End 09/2018
 
Description BBSRC Industrial Partnering Award
Amount £1,500,000 (GBP)
Funding ID BB/P022049/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 08/2017 
End 09/2020
 
Description BBSRC Industrial Partnering Award Scheme
Amount £516,308 (GBP)
Funding ID BB/J015296/1 (Role of AKT1 & SIVA1 in resistance to avian salmonellosis) 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2012 
End 09/2015
 
Description BBSRC LINK with AB Vista
Amount £830,000 (GBP)
Funding ID BB/M020738/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 08/2015 
End 08/2018
 
Description BBSRC Responsive mode
Amount £450,000 (GBP)
Funding ID BB/K005642/1 (A novel bacterial defence system against antimicrobial peptides: Implications for host colonisation in the foodborne pathogen Campylobacter jejuni) 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 12/2013 
End 12/2016
 
Description BBSRC Sparking Impact & AB Vista
Amount £14,765 (GBP)
Funding ID The development of novel egg peptides as antimicrobial feed additives for poultry 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 03/2013 
End 07/2013
 
Description BBSRC Strategic LoLa scheme
Amount £5,700,000 (GBP)
Funding ID BB/N001591/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2021
 
Description BBSRC-NIFA
Amount £417,191 (GBP)
Funding ID BB/M028208/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2015 
End 09/2018
 
Description BBSRC-NIFA scheme for UK-US collaboration on animal diseases
Amount £800,000 (GBP)
Funding ID BB/M028208/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2015 
End 09/2018
 
Description British Society for Developmental Biology PI Award
Amount £1,000 (GBP)
Organisation British Society for Developmental Biology 
Sector Learned Society
Country United Kingdom
Start 04/2017 
End 04/2017
 
Description British Society for Developmental Biology Travel Award
Amount £500 (GBP)
Organisation British Society for Developmental Biology 
Sector Learned Society
Country United Kingdom
Start 04/2017 
End 04/2017
 
Description British Society for Developmental Biology Travel Award
Amount £1,000 (GBP)
Organisation British Society for Developmental Biology 
Sector Learned Society
Country United Kingdom
Start 04/2017 
End 04/2017
 
Description British Society for Surgery of the Hand Research Grant
Amount £2,000 (GBP)
Organisation British Society for Surgery of the Hand (BSSH) 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2016 
End 08/2016
 
Description Company of Biologist Small Meeting Grant
Amount £3,000 (GBP)
Organisation Company of Biologists 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2017 
End 07/2017
 
Description Cute-Egg, improvement of eggshell cuticle quality to reduce vertical transmission of zoonotic and pathogenic organisms
Amount £603,775 (GBP)
Funding ID BB/K007092/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2013 
End 09/2016
 
Description Gene targeting of primordial germ cells using TALEN technology to generate the first knockout transgenic chickens
Amount £102,263 (GBP)
Funding ID BB/L018063/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2014 
End 09/2015
 
Description Genome-wide mapping and identification of genes controlling resistance to Marek's Disease virus infection in commercial layer chickens
Amount £637,160 (GBP)
Funding ID BB/K006916/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 06/2013 
End 10/2016
 
Description Investigating how the type and quantity of food affect foraging behaviour and the neural circuits controlling feeding in broiler breeder chickens
Amount £195,449 (GBP)
Funding ID BB/L000199/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2014 
End 06/2017
 
Description Macrophage Biology and Disease Susceptibility in Poultry
Amount £761,555 (GBP)
Funding ID BB/M011925/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 06/2015 
End 11/2018
 
Description Responsive Mode - Adam Balic - Exploitation of new technologies to advance understanding of avian dendritic cell biology
Amount £589,932 (GBP)
Funding ID BB/R003653/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 11/2017 
End 10/2020
 
Description Rooney Foundation Grant
Amount £1,000 (GBP)
Organisation William Rooney Plastic Surgery & Burns Research Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2016 
End 08/2016
 
Description Scottish Government RESAS initiative
Amount £900,000 (GBP)
Organisation Government of Scotland 
Sector Public
Country United Kingdom
Start 10/2016 
End 09/2019
 
Description Sex-determining mechanisms in the chick
Amount £454,406 (GBP)
Funding ID BB/N018672/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2020
 
Description Society Development Biology Meeting Award
Amount $4,000 (USD)
Organisation Society-Developmental Biology 
Start 07/2017 
End 07/2017
 
Description Sub-award from ISCF Transforming Food Production Seeding Award (ISCF-TFP-SA-Edinburgh). Dr Adam Balic 'Generation of a Cas9 chicken as a platform to identify causative production alleles for application in breeding programmes;.
Amount £17,848 (GBP)
Funding ID ISCF-TFP-SA-Edinburgh 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2018 
End 02/2019
 
Description The evolution and diversity of endogenous retroviral genomes in chicken brown and while egg layer populations
Amount £93,520 (GBP)
Funding ID BB/K010964/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2013 
End 09/2017
 
Description Understanding resistance and differential vaccine responses to Eimeria in the chicken - novel biomarkers and genetic control.
Amount £379,303 (GBP)
Funding ID BB/L004003/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2014 
End 08/2017
 
Description Whitaker International Program
Amount $100,000 (USD)
Organisation Whitaker International Program 
Sector Charity/Non Profit
Country United States
Start 05/2016 
End 04/2018
 
Description he role of interleukin-10 (IL-10) in the regulation of innate immunity in the domestic chicken.
Amount £1,144,442 (GBP)
Funding ID BB/P022049/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 12/2017 
End 12/2020
 
Title A sterile surrogate host chicken that can be used to revive cryopreserved chicken breeds 
Description We have developed a genetically modified chicken that can be used to revive cryopreserved chicken breeds. We used precision gene editing tools to produce a chicken with a mutation in the gene DDX4. When bred to homozygosity, the chicken does not produce any eggs. This sterile chicken can be used as a host recipient for the transplantation of oocytes from other breeds of chicken. When stem cells from a rare chicken breed are transplanted into embryos from this chicken, the offspring produced will be from the rare breed of chicken. 
Type Of Material Model of mechanisms or symptoms - non-mammalian in vivo 
Year Produced 2017 
Provided To Others? Yes  
Impact This research has led to a publication in a major scientific journal. Many press articles reported this discovery and reported the positive uses of gene editing technology for preserving rare breeds of chicken. We have communicated these results to our Japanese partner of our Japan Partner Award. This chicken is currently being used tested in an Innovate UK project to develop and resurrect a rare breed of chicken. 
URL https://www.theguardian.com/science/2017/feb/17/sterile-genetically-modified-chickens-protect-rare-b...
 
Title Antibody - Tim4 antibody 
Description A monoclonal antibody directed against chicken TIM4, a receptor for phosphatidylserine. Phosphatidylserine is expressed on the surface of apoptotic cells. Therefore this monoclonal antibody stains cells that interact with apoptotic cells. 
Type Of Material Antibody 
Year Produced 2019 
Provided To Others? Yes  
Impact In liver, highly-phagocytic TIM4hi cells shared many transcripts with mammalian Kupffer cells and were associated with uptake of apoptotic cells. TIM4 is associated with phagocytes that eliminate apoptotic cells in the chick. In the liver, TIM4 and CSF1R reporters distinguished Kupffer cells from an abundant population of DC-like cells. 
URL http://www.jimmunol.org/content/early/2019/01/08/jimmunol.1800504
 
Title Chicken line for investigating sex determination 
Description chicken line with edited sex-determining gene 
Type Of Material Model of mechanisms or symptoms - non-mammalian in vivo 
Year Produced 2018 
Provided To Others? No  
Impact N/A 
 
Title Flt3 antibody 
Description A monoclonal antibody against chicken Flt3. Flt3 is the receptor for the major dendritic cell growth factor Flt3 ligand. 
Type Of Material Antibody 
Year Produced 2017 
Provided To Others? No  
Impact Publication near completion. Antibody will be made available to other researchers upon publication 
 
Title High speed integrated spectrophotometer and analysis tool, eCutimeter 
Description Custom designed system for the rapid assessment of cuticle deposition using spectrophotometry. The final 'production' prototype was capable of rapid measurement across a range of wavelengths but was designed principally for high throughput reflectance measurement of eggs which would be used for cuticle measurement by staining. 
Type Of Material Technology assay or reagent 
Year Produced 2016 
Provided To Others? Yes  
Impact The machine is in trial at breeding organisations with a view to assessing its incorporation into breeding practice. 
 
Title Lines of edited PGCs for investigating germ cell development 
Description Lines of edited PGCs for investigating germ cell development 
Type Of Material Cell line 
Year Produced 2018 
Provided To Others? No  
Impact N/A 
 
Title prototype egg cuticle measurement device 
Description Device to hold rotate and measure surface fluorescence of an egg 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact Ability to conduct measurements for genetic evaluation . 
 
Title Avianbase: a community resource for bird genomics 
Description The Avianbase Project is an initiative led by the Roslin Institute in collaboration with the Avian Phylogenomics Consortium and Ensembl to make the initial sequence and annotation available for 48 bird species within the Ensembl framework. The Avianbase Project is using the Ensembl infrastructure to share data brought together by the Avian Phylogenomics Consortium (as part of the Avian Genome Consortium) for 48 birds. Giving access to sequence and annotation data for genome assemblies is important because, while facilitating research, it places both assembly and annotation quality under scrutiny, resulting in improvements to both. Therefore we announce Avianbase, a resource for bird genomics, which provides access to data released by the Avian Phylogenomics Consortium. 
Type Of Material Database/Collection of data 
Year Produced 2015 
Provided To Others? Yes  
Impact The Avianbase project was overviewed in the paper of 2015 (Lél Eöry, M Thomas P Gilbert, Cai Li, Bo Li, Alan Archibald, Bronwen L Aken, Guojie Zhang, Erich Jarvis, Paul Flicek and David W Burt (2015) Avianbase: a community resource for bird genomics. Genome Biology 16:21) which has been sited by over 18 times. It provides a valuable one-stop-shop to access a wealth of Avian genomic information to allow easy interrogation of genotype across species. 
URL http://avianbase.narf.ac.uk/index.html
 
Description Aviagen 
Organisation Aviagen Group
Country United States 
Sector Private 
PI Contribution We are working with Aviagen to explore the role of the chicken gut microbiome in performance of their chickens in diverse environments. So far this includes the placement of one of their staff members in my group for a short period of time for training and development
Collaborator Contribution Aviagen provide access to large commercial flocks of chickens under both controlled and natural environments
Impact No outputs so far
Start Year 2017
 
Description Aviagen 
Organisation Aviagen Group
Country United States 
Sector Private 
PI Contribution As a former Aviagen employee I continue to engage with current members of Aviagen's R&D group. Together we have partnered on one unsuccessful research application which would have utilized the NARF avian resources and facilities.
Collaborator Contribution Working with key members of the R&D team at Aviagen, we are able to access commercial know-how and the considerable IP associated with commercial genetic resources.
Impact Grant application BB/R003467/1
Start Year 2016
 
Description Charoen Pokphand (CP) group 
Organisation Charoen Pokphand Group
PI Contribution Charoen Pokphand (CP) group are a large Asian conglomerate with an interest in farming, food production and feed additives. They have placed one of their staff members with me for PhD training, fully funded by them. We are training the staff member in laboratory and bioinformatics techniques related to microbiome research in chickens.
Collaborator Contribution CP provide access to large chicken flocks both in at their farms and in their production facility. This enables us to study chicken breeds in the actual environments in which they live throughout Asia.
Impact This is a multi-disciplinary project involving both laboratory and computational techniques. The major outcome so far include a review paper (http://aem.asm.org/content/early/2018/01/29/AEM.02627-17.abstract) and the technology transfer from our group into the commercial partner.
Start Year 2017
 
Description Cherry Valley Farms 
Organisation Cherry Valley Farms
Country United Kingdom 
Sector Private 
PI Contribution There has been an ongoing partnership to develop genomic breeding programme for Cherry Valley Farms (CVF) including strategies to improve the genomic assembly for the Pekin Duck. This collaboration has led to one current grant application (successful Innovate UK) and other planned applications in the future.
Collaborator Contribution Cherry Valley Farms have provided genomic material from within all their current selection lines to enable the analyses of genetic diversity in Pekin Ducks which supply a significant proportion of global commercial duck production.
Impact Generation of significant genomic information; development and production of low density SNP panel; successful Innovate UK funding application.
Start Year 2016
 
Description Collaboration with Aviagen Ltd 
Organisation Aviagen Group
Country United States 
Sector Private 
PI Contribution The project was funded via the BBSRC LINK scheme and involved a close collaboration with Aviagen Ltd, part or the Erich Wesjohann Group and a major global breeder of poultry. In broad terms, the project sought to define the genetic basis of avian resistance to Campylobacter colonisation. This involved genome-wide association studies using the progeny of crosses of inbred lines that differ in heritable resistance to Campylobacter (specifically backcross and advanced inter-cross populations derived from lines 6 and N), and identified quantitative trait loci (QTL) associated with resistance (Psifidi et al. 2016). The project also involved a genome-wide association study using over 3000 Aviagen broilers in a simulated field context. High quality genotypes and Campylobacter colonisation phenotypes were identified for 2750 broilers and QTL associated with resistance were identified, two of which were shared with the study using inbred lines (manuscript in preparation). Studies to validate QTL and understand how they exert their effect are ongoing with core funding from the BBSRC and a grant from the Scottish Government.
Collaborator Contribution As above. Aviagen provided access to its flocks and expertise, as well as costs for genotyping and validation of QTL.
Impact See publications & additional funding sections of this return. By defining the genomic architecture of avian resistance to Campylobacter our studies will inform the scope to breed selectively for birds with improved control of an important zoonotic pathogen. Our studies show that a relatively modest proportion of the variation in the trait (caecal C. jejuni numbers) can be explained by bird genetics and that resistance-associated QTL are already prevalent in the commercial broiler line studied. Work is ongoing to validate the associations between QTL and Campylobacter levels, and understand how they exert their effect. There is scope for long-term societal gain from the research as chicken continues to be the primary reservoir of human campylobacteriosis.
Start Year 2012
 
Description Collaboration with Brian Brooks - Director, National Eye Institute. NIH 
Organisation National Eye Institute (NEI)
Country United States 
Sector Public 
PI Contribution Establishing the use of chick as a model for vertebrate structural eye development. This is novel and complements other groups use of alternative models (zebrafish and mouse) for understanding human eye development. In particular, our strengths are the investigation of structural development, such as optic fissure closure and anterior segment and iris development.
Collaborator Contribution Professor Brooks is the Director of The National Eye Institute. (NIH, US). His group is focused on the identification of mutations in genes that cause structural eye defects, and uses zebrafish to model genetic defects.
Impact Currently we have a manuscript in preprint, detailing the identification of a novel coloboma associated gene and the transcriptional landscape of tissue fusion in the embryonic chicken eye.
Start Year 2017
 
Description Collaboration with Dr Mark Fife at The Pirbright Institute 
Organisation The Pirbright Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution I was the lead applicant on this BBSRC proposal and the postdoctoral researcher deployed on the project was responsible for delivery of stated objectives.
Collaborator Contribution Dr Fife was a co-Investigator in this proposal and has played the leading role in genome-wide association studies investigating the basis of avian resistance to fowl typhoid. This has involved investigation of two naturally-occurring outbreaks for which he attracted an additional funding from Hy-Line for genotyping.
Impact We have been invited to submit a manuscript to Frontiers in Genetics in Spring 2018 related to the genome-wide association studies to map quantitative trait loci for fowl typhoid resistance in commercial layers.
Start Year 2011
 
Description Collaboration with Prof. Jim Kaufman 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution A long term collaboration where I bring expertise of the structure and understanding of commercial breeding programmes.
Collaborator Contribution With focus on the MHC, JK has helped with understanding the basis of MHC haplotype in existing bird lines. General understanding of MHC in avians.
Impact Generation of data and papers in draft.
Start Year 2016
 
Description Collaboration with Professor Dave Kelly, University of Sheffield 
Organisation University of Sheffield
Country United Kingdom 
Sector Academic/University 
PI Contribution This is a joint project led by Professor Dave Kelly at the University of Sheffield. Our component involved testing the ability of Campylobacter mutant strains lacking specific genes to colonise the intestines of chickens relative to the parent strain. Additionally, we established a Galleria mellonella 3R model to evaluate virulence of the strains.
Collaborator Contribution Provision of strains & expertise.
Impact Phenotypes for a series of mutant strains lacking specific genes, singly and in combinations, from chicken and Galleria models.
Start Year 2012
 
Description Collaboration with RVC - Eimeria 
Organisation Royal Veterinary College (RVC)
Department Pathobiology and Population Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaborative projects to explore the genetic/phenotypic basis of response to Eimeria challenge in poultry. Our expertise is in basic poultry biology and analysis of data to determine the underlying genetic basis of response.
Collaborator Contribution Our partners at RVC have in depth understanding of the pathogen Eimeria and how this impacts the bird. In addition they have technical expertise in managing challenge experiments.
Impact To date there has been publications and generation of significant data.
Start Year 2017
 
Description Collaboration with United States Department of Agriculture 
Organisation U.S. Department of Agriculture USDA
Country United States 
Sector Public 
PI Contribution USDA are partners in this BBSRC US-UK Partnering Award related to Salmonella and E. coli infections in food-producing animals. We have shared expertise, ideas & materials. A co-Investigator at the Roslin Institute (Professor John Hopkins) visited USDA researchers to transfer his expertise in surgical cannulation of lymphatic vessels, to allow the team to gain access to Salmonella and immune cells as they migrate from the intestines of cattle.
Collaborator Contribution Shared expertise, ideas & materials.
Impact Not at this stage.
Start Year 2014
 
Description Developmental basis of Radial Aplasia 
Organisation Royal Hospital for Sick Children Edinburgh
Country United Kingdom 
Sector Hospitals 
PI Contribution My research team at The Roslin Institute are developing an animal model of radial aplasia. We provide unique transgenic animal facilities, specialist skills in embryonic manipulation and the majority of intellectual contribution, understanding the developmental basis of congential radial aplasia.
Collaborator Contribution Mr W L Lam provides the insight of human congenital limb abnormalities
Impact As a result of this collaboration I have be invited to speak at several major limb surgical conferences, which has improved the communication between the clinical and scientific fields. Following this Mr WL Lam (consultant plastic surgeon, limb surgery) and myself (lead scientist) organised the first 'Clinical Workshop' at the 14th International Conference on Limb Development and Regeneration Meeting 2017 to formalize the links between the Developmental biology and Clinical Limb Surgery fields. We have established that the Clinical field lacks understanding of genetic diagnosis and fundamental biology underpinning congenital limb malformations so at this conference we including world leading leading speakers on genetic diagnosis of human congenital diseases. We have obtained funding from the British Society for Developmental Biology, The British Society for Surgery of the Hand and The Rooney Foundation to develop this project. This is a reflection on the increasing importance this collaboration has for clinical understanding of congenital disorders. We have joint published a book chapter on limb development. We have published a joint paper proposing a model to explain the developmental basis of radial aplasia.
Start Year 2015
 
Description Elucidating the mechanisms of optic fissure closure and human coloboma with Joe Rainger, Fight for Sight Fellow 
Organisation Fight for Sight
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Dr Joe Rainger developed this project in collaboration with the Davey Lab, moving from understanding the mechanisms of optic fissure closure in mammals to chicken. Dr Rainger has undertaken the fellowship with the Davey group and with technical and intellectual support from Megan Davey, who also provides training for Dr Rainger and his student as well as providing space and equipment.
Collaborator Contribution Dr Rainger brings expertise in mechanism of embryonic eye growth and development, elucidation of novel loci causing coloboma and knowledge of the Actin cytoskeleton. Dr Davey provides mentoring, training in chicken developmental techniques and
Impact • Rainger J, Williamson KA, Soares DC, Truch J, Kurian D, Gillessen-Kaesbach G, Seawright A, Prendergast J, Halachev M, Wheeler A, McTeir L, Gill AC, van Heyningen V, Davey MG; UK10K, FitzPatrick DR.(2017) A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma. Hum Mutat. PMID: 28493397. We have secured funding for a joint PhD student. We have co-organised an international developmental biology meeting (Joint BSDB/Nordic Conference on Developmental Biology and Regeneration 2017).
Start Year 2015
 
Description Evaluation and validation of membraneGFP transgenic embryos for in vivo imaging 
Organisation University of Dundee
Department School of Life Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution We developed a lentiviral vector to deliver a transgene designed to express membrane-localised Green Fluorescent Protein (GFP) ubiquitously in chicken embryos. We generated a transgenic line carrying this vector and provided chicken embryos to the Weijer lab for them to evaluate and develop in vivo imaging technologies.
Collaborator Contribution The Weijer lab advised on transgene design and developed in vivo imaging using light sheet microscopy.
Impact This collaboration lead to a publication Rozbiki et al. (2015) Nature Cell Biology 17, 397-408 and the use of this research tool in the Weijer lab is ongoing, funded by new grants.
Start Year 2012
 
Description Evaluation of Notch-reporter transgenic embryos 
Organisation École Normale Supérieure, Paris
Department Institute of Biology
Country France 
Sector Academic/University 
PI Contribution We developed a line of transgenic chickens carrying a transgene that would express green fluorescent protein as a reporter of notch signalling activity.
Collaborator Contribution The partners utilised embryos from this line to exemplify its utility in experiments to understand vertebrate embryo development.
Impact A paper has been published.
Start Year 2016
 
Description ILRI 
Organisation International Livestock Research Institute (ILRI)
Country Kenya 
Sector Charity/Non Profit 
PI Contribution We work with ILRI on all aspects of genomics and data science, including whole genome sequencing of multiple African animals, data recording and database design, web and web content development, and bioinformatics training.
Collaborator Contribution We work with ILRI on all aspects of genomics and data science, including whole genome sequencing of multiple African animals, data recording and database design, web and web content development, and bioinformatics training.
Impact So far we have sequenced the genomes of approx 800 African farm animals from diverse breeds and ecotypes
Start Year 2016
 
Description Pirbright Institute 
Organisation The Pirbright Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution We have provided avian material to support the research efforts across multiple groups at the Pirbright institute. The Director of the NARF attends poultry user meetings at the Pirbright to ensure we are able to continue to support ongoing research needs.
Collaborator Contribution The recipients of material provide feedback on the quality and performance of the avian materials to help us ensure continued quality. We are in close contact regarding the development of future avian resources to specifically support the Pirbright research requirements.
Impact Supply of avian material to support ongoing research!
Start Year 2012
 
Title Addition of new gene associated with eye disorder into molecular diagnostic screening panel in scottish NHS 
Description Identification of mutations in ACTG1 gene led to its inclusion in medical diagnostic screens for patients with inherited eye malformations 
Type Management of Diseases and Conditions
Current Stage Of Development Small-scale adoption
Year Development Stage Completed 2017
Development Status Closed
Impact Refinement of known disease genes for ocular birth defects 
 
Company Name ROSLIN TECHNOLOGIES LIMITED 
Description Roslin Technologies is an agriculture biotechnology company that has been established as the commercialisation arm of the world renowned Roslin Institute and University of Edinburgh's Royal (Dick) School of Veterinary Studies. As well as developing a range of new products, we offer a strong platform for industry engagement through a range of services, licencing and collaboration opportunities. Located at the University's Easter Bush Campus which is part of the Midlothian Science Zone, Roslin Technologies is well placed to play a leading role in delivering strong industry impacts from new developments in Agri-tech. Although still rapidly developing, the Zone is already one of the largest animal science innovation hubs in the world, being home also to a number of organisations with animal science expertise and an international reputation for conducting world class research and teaching. Roslin Technologies is a joint venture that builds upon a strong and novel partnership between the world leading research, knowledge and expertise that is contained within the University of Edinburgh, and two investment and business development partners with a strong global network and reach. 
Year Established 2016 
Impact Roslin Technology (commercial partner of Roslin Institute) is currently offering a commercial biobanking service to the poultry industry to biobank commercial chicken flocks using the technology partially developed in this grant. The commercial partner of this grant, Cobb Vantress, Inc, has granted Roslin Technology the right to commercially exploit the non-patentable IP from this project and has made use of this commercial biobanking service offered by Roslin Technology. I, Mike McGrew, am a consultant for the commercial biobanking service.
Website http://roslintech.com/avian-germline-cryopreservation/
 
Description "Determining the Interacting Network of TALPID3 through Proteomic Studies" Cold Spring Harbour Centrosome Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A description of work discovering the fundamental proteins involved in action of the centrosome via chicken mutants
Year(s) Of Engagement Activity 2017
 
Description "Fate mapping the limb using Chameleon"- Julia Oh 14th ICLDR 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A talk describing the use of The Roslin Institute transgenic bird lines and their uses.
Year(s) Of Engagement Activity 2017
 
Description "Spots, Stripes and Rainbows" Avian Systems Meeting 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A talk describing the use of The Roslin Institute chicken transgenic lines to a scientific audience
Year(s) Of Engagement Activity 2018
 
Description "Using the developing choroid plexus to explore cilia transcriptomics" Cold Spring Harbour 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A talk to 120 scientists about the use of transcriptomics to understanding ciliogenesis
Year(s) Of Engagement Activity 2017
 
Description "Walking with the Feet of Dinosaurs" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact 40 undergraduate students from the University of Edinburgh Zoological Club attended the talk. Subsequently students came to undertake research at The Roslin Institute
Year(s) Of Engagement Activity 2017
 
Description "Where did the 5th Toe Go" University of Basel 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A talk describing the use of The Roslin Institute transgenic bird lines and their uses.
Year(s) Of Engagement Activity 2018
 
Description "Where did the 5th Toe Go?" 14th ICLDR 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A talk describing the use of The Roslin Institute transgenic bird lines and their uses.
Year(s) Of Engagement Activity 2017
 
Description 24th Annual Meeting of Biology Teachers 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A forward looking discussion on the role of genetic selection and genome engineering in order to update biology teachers on new technologies
Year(s) Of Engagement Activity 2019
 
Description 32nd Leeds Symposium on Food History and Traditions, York, UK( April 2017) "Birds for the Table", I presented a lecture entitled "Chykenns in cawdel to KFC: development of the modern broiler chicken". 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact I organised the theme and guest list for the 32nd Leeds Symposium on Food History and Traditions, York, UK ( April 2017) "Birds for the Table". I also presented a lecture entitled "Chykenns in cawdel to KFC: development of the modern broiler chicken. The purpose of this talk was to communicate how the modern broiler chicken was developed from earlier chickens and red jungle fowl ancestors; and how modern broiler production is managed.
Year(s) Of Engagement Activity 2017
 
Description Cafe Scientifique, Brighton Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Talk in the Brighton Science Festival October 27 2018, "Genome editing in agriculture - a new apprpach or still GM?". Broad audience of engaged public including students from an access course, who engaged in long question/answer and discussion session after talk.
Year(s) Of Engagement Activity 2018
URL http://www.brightonscience.com/events/genome-editing-in-agriculture/
 
Description Communicating science to lay audiences 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Pint of Science: Why eye can see. Described birth defects affecting the eyes and how they can arise and how we are able to genetically diagnose them, with a view to opportunities for disease management and potential therapies.
Year(s) Of Engagement Activity 2017
URL https://pintofscience.co.uk/event/why-eye-can-see
 
Description Conference Organiser- The 14th Limb Development and Regeneration Meeting Clinical Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact As an addition to the 14th Limb Development and Regeneration Conference, I organised a Clinical Workshop to engage the specialist discipline of congenital hand/foot surgeons, to better integrate the clinical aspects of limb development with the developmental biology.
Year(s) Of Engagement Activity 2017
URL https://www.ed.ac.uk/igmm/news-and-events/events/latest-events/limb-development-2017
 
Description Edinburgh scientists working to create safer eggs 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact News coverage of egg cuticle story. 'Cute egg'
Year(s) Of Engagement Activity 2018
URL https://www.bbc.co.uk/news/uk-scotland-edinburgh-east-fife-43605254
 
Description Evonik research day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact I presented my work on precision analysis of microbiomes to Evonik, an international company with over 13000 employees and with interests in chemical and food production. This was part of a one day workshop with Evonik, hosted by Roslin and focused on microbiomes
Year(s) Of Engagement Activity 2018
 
Description Feature for BBC2 Food Detectives programme 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Professor Stevens took part in a BBC2 Food Detectives programme which featured Campylobacter in chickens. He helped to design a survey of Campylobacter contamination in a sample of fresh chicken obtained from Scottish retailers and interpret the findings. This were close to Food Standards Agency findings, which were broadcast as part of an interview with Prof. Alice Roberts. The interview took place at The Roslin Institute and included a lay description of Campylobacter, the importance of chickens as a reservoir of infection and strategies by which consumers can protect themselves. It also highlighted BBSRC-funded work at Roslin to mitigate the problem based on genetic selection (this project) and vaccines (other BBSRC projects held by Prof. Stevens).
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/programmes/b077rgd4
 
Description Invited speaker - Avian Genetics and Immunity Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Research on Avian Genetics and Immunity (RAGI) has been established to strengthen global partnerships and links between academic researchers, students and the poultry professionals working on the genetics of avian immunity. The purpose of the symposium was to provide a forum for discussion and exchange of ideas around the single theme of exploiting available opportunities in ultimately dealing emerging and existing infectious avian diseases in poultry production systems and to safeguard food supplies and human health.
The purpose of KW talk was to overview the current situation in industry for breeding for disease resistance and introduce the NARF. The overview of NARF included a review of facilities, lines available and current work being carried out using NARF avian lines. The presentation stimulated significant discussion.
Year(s) Of Engagement Activity 2017
URL http://geneticsandimmunity.com/
 
Description Invited speaker - society of feed technologists 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The Society of Feed Technologists (SFT), provides a forum open to those interested in the production and welfare of farmed livestock. The group was multi-disciplinary and included animal nutritionists, feed technologists, recipe formulators, academics, pharmacologists, veterinary surgeons, geneticists, feed mill managers and farm advisers. KW was invited to speak at their 50th Anniversary Celebration to discuss the role of genetics in current developments in pig and poultry production "Genetic developments and their future application to pig and poultry production". The presentation precipitated a wealth of discussions the current and future developments for Europe's poultry production industry.
Year(s) Of Engagement Activity 2007
URL https://sft.uk.com/events-conferences/past-test-event/
 
Description News artcile on BBC news website 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A press release was developed relating to our publication in BMC Biotechnology describing production and purification of bioactive proteins in the eggs of transgenic hens. This article was written by Pallab Ghosh of BBC and attracted a lot of attention and other news articles across the world. Contacts have been received from interested businesses.
Year(s) Of Engagement Activity 2019
URL https://www.bbc.co.uk/news/uk-scotland-47022070
 
Description Presentation to Gates Foundation and DfID 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Mick Watson presented work on African farm animal genomics and data science to attendees from the Bill and Melinda Gates Foundation (BMGF) and the department for international development (DfID)
Year(s) Of Engagement Activity 2017
 
Description Public lecture entitled Confronting the Microbial Menace in Our Food'. Professor Mark Stevens 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact The inaugural lecture of Professor Mark Stevens was held on 30 October 2017 on his BBSRC-funded research to identify bacterial and host factors influencing the ability of Salmonella, Campylobacter and E. coli to colonise farm animals and cause disease. It was attended by children from local schools, members of the public, students at The Roslin Institute and wider University of Edinburgh and posted online.
Year(s) Of Engagement Activity 2017,2018
URL https://media.ed.ac.uk/media/Inaugural+lectureA+Confronting+the+microbial+menace+in+our+food/1_x5k5e...
 
Description Public lecture on Campylobacter in chickens 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Public talk on 'Chickens and the enemy within' at The Roslin Institute Open Doors Day in 2012. This highlighted the problem of Campylobacter infections in people, the role of poultry as a reservoir, and research at Roslin to control the problem via genetic selection and vaccination in poultry and to understand the molecular basis of virulence of the organism.
Year(s) Of Engagement Activity 2012
 
Description Published article received press coverage 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Published article discussed in public online forum
Year(s) Of Engagement Activity 2017
URL http://www.bbc.co.uk/news/uk-scotland-edinburgh-east-fife-39006713
 
Description Published article receiving press coverage 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Press article on gene targeted chicken used to study germ cell development and to develop surrogate host chickens for rare breed conservation
Year(s) Of Engagement Activity 2017
URL https://www.ft.com/content/10000b26-f52c-11e6-8758-6876151821a6
 
Description Published article receiving press coverage 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Press article in the Telegraph describing biobanking of chicken breeds using GM chicken hosts in a positive light
Year(s) Of Engagement Activity 2017
URL http://www.telegraph.co.uk/news/2017/02/17/rarechickensbrought-back-brink-extinction-edinburgh-unive...
 
Description Radio interview arising from publication 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact I was interviewed following my research paper publication, on the Royal National Institute of Blind People (RNIB) Connect Radio programme. This interview was to raise awareness of the birth defect Coloboma, and to disseminate the successful identification of new coloboma-causing mutations and my research program working towards improving our understanding of the causes of the condition.
Year(s) Of Engagement Activity 2017
 
Description Talk to patient group for Primary Ciliay Dyskinesia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact To mark PCD Awareness Day I talked on my models for PCD and the potential for large animal models using genome engineering
Year(s) Of Engagement Activity 2018
 
Description The Avian Immunology Research Group (AIRG) 2018 meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation "Identification and characterisation of avian conventional dendritic cells"
Year(s) Of Engagement Activity 2018
 
Description Visit by Bill Gates and the Secretary of State for the Department of International Development 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Bill Gates and the Secretary of State for the Department of International Development (DfID; Rt Hon Penny Mordaunt) visited The Roslin Institute on 26 January 2018. This involved separate sessions with the Gates Foundation and DfID to learn about the research undertaken by the Centre for Tropical Livestock Genetics & Health (CTLGH), in which the Roslin Institute is a major partner and researchers in the Institute Strategic Programmes are heavily involved. DfID announced £4m of funding for the CTLGH, adding to £10m already received from the Gates Foundation. In the presence of the Principal of the University of Edinburgh, Bill Gates and the Rt Hon Penny Mordaunt formally opened the Global Academy for Agriculture & Food Security which will provide undergraduate and postgraduate training in sustainable agriculture. The event took place in the new Campus Innovation Building (which received BBSRC strategic funding). The University of Edinburgh press office tracked the following activity related to the visit, in which many participants in the ISPs were involved:

• 109 individual articles and broadcast pieces that mentioned the University with regards to the visit, with an estimated potential reach of more than 7 million people.

• Of these, more than half of the coverage mentioned one of more of the Global Academy of Agriculture & Food Security, the Centre for Tropical Livestock Genetics & Health, SEBI, the Royal (Dick) School of Veterinary Studies, Roslin or the Easter Bush Campus in addition to name checking the University.

• In addition to the UK, we also attracted press coverage in the USA, France, New Zealand, China, Zimbabwe, South Africa, Botswana, Taiwan and Egypt.

• Across social media, we reached more than 1.4 million people with 14k+ engagements (likes, shares, retweets etc). Of these, 99.8% were positive.

• The Facebook Live streaming alone reached more than 100k people. More than 18k people have watched the video.

• Our news videos have garnered more than 35k views across platforms.

• We tracked a spike in traffic to the Global Academy website on the day of the visit - 1405 visits (11 times the average for the previous month).
Year(s) Of Engagement Activity 2018
 
Description Visit of Bill Gates 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Bill Gates and Penny Mordaunt visited the Easter Bush campus to open the new Global Academy for Food Security. At that event, I presented our work on african farm animal genomes and programme 5 of the CTLGH.
Year(s) Of Engagement Activity 2018
URL https://www.gov.uk/government/speeches/penny-mordaunt-speech-at-edinburgh-university-with-bill-gates
 
Description editorial on uses of GM 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Presented to reporters at AAAS, Boston USA
Year(s) Of Engagement Activity 2017