Determinants of microbe-host responses in the gut across life

Lead Research Organisation: Institute of Food Research
Department Name: Contracts

Abstract

To probe specific mechanistic aspects of the gut microbiome's positive influence on health throughout life, we have developed a systems-level experimental approach. We will use innovative in vivo, in vitro, and in silico tools/models in tandem with a key longitudinal cohort (pregnancy and early life) to define and refine novel intervention strategies that will promote gut health. Our multi-disciplinary research theme managed by QIB and university research leaders, maps to three objectives. These objectives will determine how microbes (bacterial, viral, fungal) establish and maintain a balanced community that modulates host homeostatic cross-talk within the gut.
This theme involves a 250-particpant longitudinal population study of pregnancy mothers and their infants, up to 2 years of age.
Theme 1 focusses on the gut during the very first stages of life, and in the elderly, and will seek to unravel: (i) how pioneer/keystone microbial species facilitate healthy development (ii) which microbial mediators modulate microbe-microbe and microbe-host cross-talk and (iii) bi-directional immune system-microbiota interactions within the gut.
Theme 1 Outputs
• identification of critical pre- and post-natal periods for establishing a healthy intestinal microbiome and the contribution that host and environmental factors play
• define molecular mediators of microbe-microbe and microbe-host crosstalk important in microbial ecology and establishing tolerance
Our integrated plan of work will ultimately determine microbiome- and host-associated pathways that could represent key targets for lifestyle changes and therapies that reduce the incidence and burden of infectious, metabolic, and immune-mediated conditions.

Publications

10 25 50
 
Title Bifidobacterium bronze and perfume sculpture - Wellcome Collection (Being Human) 
Description Food historian and artist Tasha Marks of AVM Curiosities has developed a playful bronze and perfume sculpture which suggests the smell of breast milk and celebrates the microbiome and our symbiotic relationship with bacteria. This was in collaboration with Dr Lindsay J Hall 
Type Of Art Artwork 
Year Produced 2019 
Impact This has enhanced the public's knowledge on the links between certain microbiota members i.e. Bifidobacterium and early life diet - breast milk. 
URL https://wellcomecollection.org/pages/XW5QMBEAACUAELBV
 
Title Guardians of the Gut Exhibit 
Description "Guardians of the Gut": 6-meter-long, 2-meter-high gut, with internal game stations which allowed visitors to interact with their 'microbes 
Type Of Art Artistic/Creative Exhibition 
Year Produced 2018 
Impact This exhbit has been shown at the Royal Society Summer Exhibition and Norwich Science Festivals 2018 
 
Description Membership of R&D Executive Committee influencing educational and research policy updated annually
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Membership of a guideline committee
 
Description UK Government PostNote
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://researchbriefings.parliament.uk/ResearchBriefing/Summary/POST-PN-0574
 
Description CLRN Flexibility & Sustainability Research Funding
Amount £55,975 (GBP)
Funding ID RDFSF025 
Organisation London North West Healthcare NHS Trust 
Sector Public
Country United Kingdom
Start 08/2018 
End 07/2019
 
Description Immune Response to Q-fever
Amount £99,990 (GBP)
Organisation Defence Science & Technology Laboratory (DSTL) 
Sector Public
Country United Kingdom
Start 04/2019 
End 03/2021
 
Description New antimicrobials to target gut pathogens
Amount £20,000 (GBP)
Funding ID 2116844 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2018 
End 09/2023
 
Description Norwich Research Park Bioscience Doctoral Training Partnership
Amount £100,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2018 
End 10/2022
 
Description Norwich Research Park Bioscience Doctoral Training Partnership
Amount £100,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2015 
End 09/2019
 
Description Norwich Research Park Bioscience Doctoral Training Partnership
Amount £100,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2016 
End 10/2020
 
Description Phage Future: Gut phages for the biocontrol of AMR pathogens
Amount £106,000 (GBP)
Funding ID 2282982 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2019 
End 03/2023
 
Description QIB Proof of Concept:
Amount £7,000 (GBP)
Organisation Quadram Institute Bioscience 
Sector Academic/University
Country United Kingdom
Start 03/2019 
End 07/2019
 
Description ReStrain: Discovery of markers of a healthy gut microbiome through computational and experimental means (academic-industry collaboration)
Amount £80,000 (GBP)
Funding ID 2246539 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2019 
End 09/2023
 
Description Research contract
Amount £99,990 (GBP)
Funding ID 1000137348 
Organisation Defence Science & Technology Laboratory (DSTL) 
Sector Public
Country United Kingdom
Start 03/2019 
End 02/2021
 
Description Reservoirs of mobile antibiotic resistance genes in the gut microbiome of preterm infants
Amount £588,844 (GBP)
Funding ID BB/S017941/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 08/2019 
End 08/2022
 
Description St Marks Foundation Research Grants
Amount £216,138 (GBP)
Funding ID RES209 
Organisation St Marks Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2017 
End 10/2020
 
Description St Marks Hospital Studentship
Amount £20,996 (GBP)
Organisation St. Mark's Hospital Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2020 
End 12/2022
 
Description Training interdisciplinary glycoscientists to get a molecular- level grip on glycocodes at the human mucosa-microbiota
Amount £466,300 (GBP)
Funding ID 814102 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2019 
End 12/2022
 
Description iCASE doctoral training programme
Amount £69,900 (GBP)
Funding ID Enterprise DTP: MRC iCASE Studentship 2019-20 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2019 
End 03/2023
 
Description Collaboration with EAGLE genomics, Cambridge 
Organisation Eagle Genomics Ltd
Country United Kingdom 
Sector Private 
PI Contribution Engagement with industry, resulting in knowledge sharing
Collaborator Contribution in kind contributions to HPC usage
Impact -shared studentship -shared knowledge & data
Start Year 2019
 
Description Polyposis Team 
Organisation St Mark's Academic Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution St Marks Academic Institute for the Study of Colorectal Diseases is a national and international referral centre for colorectal diseases. Partnering with the Polyposis Team is enabling immune profiling of patients with pre-malignent conditions in relation to the gut microbiota.
Collaborator Contribution Provision of clinical expertise and material
Impact Development of a new Ethical Committee approval - 17/LO/16/36 Changes in immune responses to gut microbiota have been identified in pre-malignant cancer patients with APC gene mutations. We are identifying basic immune parameters that may predispose to the development of malignancy raising the possibility of individualised diagnosis / treatment.
Start Year 2018
 
Description Structural biology 
Organisation University of Oxford
Department Oxford Hub
Country United Kingdom 
Sector Academic/University 
PI Contribution Identified and functionally characterised a novel enzyme activity in gut bacteria
Collaborator Contribution Crystallisation of metabolic enzyme involved in carbohydrate utilisation by bacteria
Impact Manuscript in preparation 3D Structure
Start Year 2019
 
Description TROVE project 
Organisation St Mark's Academic Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution We provide laboratory facilities, immunological expertise to inform experimental design, laboratory training, data analysis and student supervision and training.
Collaborator Contribution Clinical expertise and patient profiling and samples
Impact Participation in the TROVE research project with clinical partners has allowed us to explore the relevance of efferent lymph feeding to the establishment of the microbial fauna in the gut and the resultant immune profiles in response to individual bacteria. Preliminary evidence indicates that profiling may be used in diagnosis and potentially in bacterial treatment with designer probiotics in the future.
Start Year 2018
 
Description Identifying signalling pathways regulating antimicrobial peptide production in the gut using network biology and organoid transcriptomics Modularity of signaling proteins and networks 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Identifying signalling pathways regulating antimicrobial peptide production in the gut using network biology and organoid transcriptomics Modularity of signaling proteins and networks
Year(s) Of Engagement Activity 2018
 
Description Investigating regulation of intestinal function by Bifidobacteria using network biology and organoid approaches, Microbes in Norwich 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Investigating regulation of intestinal function by Bifidobacteria using network biology and organoid approaches, Microbes in Norwich
Year(s) Of Engagement Activity 2019
 
Description 17-21 July 2017_2nd Interdisciplinary Signaling Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact In this interdisciplinary workshop advanced science was combined with informal summer activities to solve multi-disciplinary scientific questions, by bringing early career scientists together with more established researchers in a relaxing and beautiful location.

Invited speakers presented talks on the topics of cell regulation, network modelling, genomics, systems biology, bioinformatics, structural biology, biochemistry, and cheminformatics. Then, selected talks from other participants will be followed by multi-disciplinary teamwork sessions in the afternoon, followed by cultural and social activities, such as medieval team building and handicraft activities in the Visegrad Castle. Poster sessions and plenty of informal opportunities allowed the participants to discuss complex and exciting questions as well as develop new collaborations. The renaissance surroundings of the venue nicely matched with the interdisciplinary nature of the workshop.
Year(s) Of Engagement Activity 2017
URL http://signalingworkshop.org/
 
Description 24-25 April 2017_Multiscale analysis of host-microbe interactions in plants, animals and humans 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact The aim of this workshop was to bring together key experts and early-stage scientists working on host-microbe interactions, including pathogen infections, commensals and microbiome level studies, to share novel scientific ideas on the multiscale investigation of host-microbe interactions and to provide an exciting opportunity to establish and improve cross-disciplinary and UK-wide collaborations.

After kick off with three keynote speakers on current challenges, the program provides structured study groups to discuss 1) novel methodological approaches; 2) potential future projects requiring participants from different disciplines; 3) the best ways to get funding for such multi-disciplinary projects. We facilitated these goals with short presentations and brainstorming opportunities in coordinated team works, and with panel discussion with representatives of key relevant funding agencies and charities.
Year(s) Of Engagement Activity 2017
URL http://www.multiscalebiology.org.uk/events/event/multiscale-analysis-of-host-microbe-interactions/
 
Description 4th Annual European Microbiome Congress 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Attendance to 4th Annual European Microbiome Congress. This Conference has a high representation from the Industry: Pharmaceutical companies and Biotechnology companies and provided an excellent opportunity to make contact and discuss work relevant to the Institute Strategic Programmes. The PROMOTING WOMEN IN SCIENCE lunch session was inspiring.
Year(s) Of Engagement Activity 2018
 
Description Academia-Industry Networking CarboMet event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact I co-organised and chaired a two day workshop on 'The Role of Carbohydrates in the Gut Microbiome' June 2018 in Brussels attended by 40 delegates from academia and industry as apart of CarboMet. CarboMet (Metrology of Carbohydrates for European Bioindustries) is a four-year Coordination and Support Action (CSA) funded by Horizon 2020 FET-OPEN. It is an European Network that facilitates engagement between key players and stakeholders of the glycoscience community across Europe to identify the current state of the art and in particular future innovation and technological challenges in carbohydrate metrology. I co-wrote and edited the CarboMet positioning paper on 'The Essential Roles of Carbohydrates in Promoting Gut Microbiota Function Through All Stages of Life' which summarises discussions that took place during the workshop.
Year(s) Of Engagement Activity 2018
URL https://carbomet.eu/news/positioning-paper-on-role-of-carbohydrates-in-gut-microbiota-function/
 
Description Analysing intestinal organoids in a multi-omics, systems biology framework to investigate gut health and host-microbe interactions Scientific Advisory Board Meeting Earlham Institute 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Analysing intestinal organoids in a multi-omics, systems biology framework to investigate gut health and host-microbe interactions Scientific Advisory Board Meeting Earlham Institute
Year(s) Of Engagement Activity 2019
 
Description Analyzing intestinal organoids in a multi-omics, systems biology framework to investigate gut health and host-microbe interactions SYSBIO 2018 - Advanced Lecture Course on Systems Biology 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Analyzing intestinal organoids in a multi-omics, systems biology framework to investigate gut health and host-microbe interactions SYSBIO 2018 - Advanced Lecture Course on Systems Biology
Year(s) Of Engagement Activity 2019
 
Description Annual Aberdeen University Microbiology Schools Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Talk to approx 150 17-18 year old school children about important of the gut microbiome and also gave a career talk. Feedback received was very positive with students thinking about microbiology as a degree.
Year(s) Of Engagement Activity 2018
 
Description Article for the 'Microbiologist' 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact Article written for SfAM magazine 'Microbiologist': First Contact: The importance of the early life microbiota
Year(s) Of Engagement Activity 2018
 
Description BIA Webinar 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Arjan Narbad, Lindsay Hall and Alan Walker gave a live BIA webinar to industry members. the webinar was then published on You tube that everyone can access. The title of the Webinar was Developing, feeding and restoring the human microbiome' where Dr Lindsay Hall explained 'Early Life Microbiota' , Dr Alana Walker presented 'Diet and the gut microbiota' and Professor Arjan Narbad gave a presentation on 'Restoring the gut microbiome
using FMT' more than 370 people have now seen the webinar.
Year(s) Of Engagement Activity 2018
URL https://www.youtube.com/watch?v=OtcoxvQvG34
 
Description BIA Webinar: Developing, feeding and restoring the human microbiome 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact BIA Webinar: Developing, feeding and restoring the human microbiome. In an interactive webinar with questions from industrial representatives.
Year(s) Of Engagement Activity 2018
 
Description Bioinformatics workshop at the Evergreen Phage Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 30 postgraduate students and early career researchers attended a workshop on the use of command-line tools in the analysis of virome data, as part of the Evergreen International Phage Biology meeting in Olympia, WA, USA
Year(s) Of Engagement Activity 2019
 
Description CLIMB computing workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact I thought bioinformatics at a CLIMB workshop in Edinburgh organized by Mark Pallen.
Year(s) Of Engagement Activity 2019
 
Description Comparative analysis of Paneth cell and enteroendocrine cell transcriptomics: organoid and signalling network based approaches Research in progress talk at Quadram Institute. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Comparative analysis of Paneth cell and enteroendocrine cell transcriptomics: organoid and signalling network based approaches
Research in progress talk at Quadram Institute.
Year(s) Of Engagement Activity 2019
 
Description Computational Systems Biology 2: Analysing and visualising networks 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Training for local PhD students: Computational Systems Biology 2: Analysing and visualising networks
Year(s) Of Engagement Activity 2019
 
Description Cytokine responsive transcriptional networks in inflammatory bowel disease 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation to ~50 scientists and clinicians at the 6th Young European Crohns and colitis organisation basic science program in Vienna, Austria.
Year(s) Of Engagement Activity 2020
URL https://www.ecco-ibd.eu/discover-the-programme-2020/educational-programme-2020/6th-y-ecco-basic-scie...
 
Description Dialogue event with Older People's Community (public) Group about the microbiome and potential idea for future clinical trial 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Dialogue with Broadland Older People's Partnership Group about the microbiome and its impact on health and immunity in older age. Discussion of the components of the microbiome and what and how this can be affected - and the implications for other organ systems. Plenty of discussion with many opinions and questions expressed.
Year(s) Of Engagement Activity 2019
 
Description Dialogue events with Patient Participation Groups (PPGs) about the microbiome and potential idea for future clinical trial 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Seven (separate) dialogue events with Patient Participation Groups (PPG) at GP practices across Norfolk to discuss the microbiome with patients and a potential idea for a future clinical trial.
Discussions included: composition of microbiome, importance of gut health and impact on immunity and effect on other organs, FMT, gut-brain link, changes in microbiome throughout the life course, probiotics, prebiotics and superfoods, immunosenescence, antibiotics.
Plenty of discussion and debate at each event with opinions often expressed as changing by the end of each dialogue.
Year(s) Of Engagement Activity 2019,2020
 
Description EI LotuS training 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact I organized the session (lecture + hands-on training) for amplicon sequencing, that was part for the EI metagenomics workshop.
Year(s) Of Engagement Activity 2019
 
Description Earlham Institute open day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Talk to ~50 members of the public sparking questions and discussion about probiotics and a healthy gut microbiome.
Year(s) Of Engagement Activity 2019
URL https://www.earlham.ac.uk/open-day-2019
 
Description Earlham Institute open day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Discussions with variety of audiences about gut bacteria and probiotics.
Year(s) Of Engagement Activity 2019
URL https://www.earlham.ac.uk/open-day-2019
 
Description Evolution and ecological interactions of gut bacterial taxa in challenged ecosystems 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I was invited to give a talk "Evolution and ecological interactions of gut bacterial taxa in challenged ecosystems" at the SMBE conference in Manchester, 2019
Year(s) Of Engagement Activity 2019
URL http://smbe2019.org/
 
Description IBCarb 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Contributed to the final IBCarb workshop Glycobiotechnology 2018. IBCarb (Glycoscience Tools for Biotechnology and Bioenergy) is a growing network of glycoscientists from academia and industry. IBCarb was one of the Networks in Industrial Biotechnology and Bioenergy funded by the BBSRC. The workshop was very successful and attracted around 150 attendees (international audience from academia and industry) . This was an opportunity to showcase the Glycosciences carried out in the UK and in partnership with industrial/business partners.
Year(s) Of Engagement Activity 2018
URL https://ibcarb.com/events/
 
Description Identification of master regulators in goblet cells and Paneth cells using transcriptomics profiling of gut organoids and multi-layered networks. QIB Research in Progress 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Identification of master regulators in goblet cells and Paneth cells using transcriptomics profiling of gut organoids and multi-layered networks. QIB Research in Progress
Year(s) Of Engagement Activity 2019
 
Description Interview for Radio 4 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Invited interviewee for Radio 4 programme: Inside Health. Numerous followups for further information and also engagement from Industry for new collaborations has resulted from broadcast.
Year(s) Of Engagement Activity 2020
URL https://www.bbc.co.uk/programmes/m000dpky
 
Description Interviewed and quoted in BBC Future article 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Was interviewed and quoted in BBC Future article: What we and don't know about gut health
Year(s) Of Engagement Activity 2019
URL http://www.bbc.com/future/story/20190121-what-we-do-and-dont-know-about-gut-health
 
Description Introduction to Multiomics Data Integration 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Tamas Korcsmaros delivered a talk on the nature of different data types, and provided a training on Cytoscape
Year(s) Of Engagement Activity 2009,2018
URL https://www.ebi.ac.uk/training/events/2018/introduction-multiomics-data-integration-0
 
Description Invited Lecture - St Mark's Frontiers in Intestinal failure, Royal Society of Medicine, November 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited Lecture presented by member of Antigen Presentation Research Group at St Mark's Frontiers in Intestinal failure, Royal Society of Medicine, November 2019.
International conference open to clinical staff, researchers and the general public - successfully reaching new/wider audiences. Potential for new research activity.
Presenter won John Nichols prize.
Year(s) Of Engagement Activity 2019
 
Description Invited lecture 23rd Biennial Evergreen International Phage Biology Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited lecture on phage taxonomy. The audience reported increased understanding of the importance of phage taxonomy in data analysis and changing behaviours.
Year(s) Of Engagement Activity 2019
 
Description Invited oral presentation at mini symposium on viruses and their classification, Utrecht University, The Netherlands, March 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Invited oral presentation at mini symposium. Title "Detection of food- and waterborne viruses using viromics: Will eating shellfish make you sick?"
Year(s) Of Engagement Activity 2019
 
Description Invited web seminar for the NASA Astrobiology Institute "Astrovirology Virtual Workshop Without Walls" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Web seminar on Virus Taxonomy: What is it and why should I care? for the NASA Astrobiology seminar series
Year(s) Of Engagement Activity 2019
URL https://nai.nasa.gov/seminars/featured-seminar-channels/workshops-without-walls/2019/9/18/astrovirol...
 
Description Jolly good fellows: building a career at Earlham Institute - 20/02/2020 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Website article showcasing fellowship programmes at EI including Tamas Korcsmaros, whose five year fellowship which has led to a large and successful group investigating computational and network-based approaches to understanding complex systems such as the gut. Dr Korcsmaros is the CSP WP2 Lead.
Year(s) Of Engagement Activity 2019
URL http://www.earlham.ac.uk/articles/jolly-good-fellows-building-career-earlham-institute
 
Description Latitude Music Festival: Exhibited Guardians of the Gut 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact We exhibited our Guardians of the Gut Exhibit at Latitude Festival in July 2019 over 3 days to members of the public (over 5000), We also had several specific school visits (~60 children in total). We received excellent feedback and strong engagement and questions.
Year(s) Of Engagement Activity 2019
 
Description LotuS workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact I co-organized (with VIB, Belgium) and led a 1 day workshop on the usage of the lab developed LotuS, teaching about 20 participants in Leuven, Belgium.
Year(s) Of Engagement Activity 2019
URL https://wiki.bits.vib.be/index.php/NGS_data_analysis#Training_5:_metagenomics
 
Description Lotus tutorial: website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Training website for the LotuS software that is under active development in my lab
Year(s) Of Engagement Activity 2019,2020
URL https://github.com/telatin/lotus-tutorial
 
Description Member of expert working group for design of new permanent exhibit 'Being Human' at the Wellcome collection. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact This a large permanent exhibit housed in the Wellcome Collection (London) that was opened in September 2019. Wellcome are collecting feedback on exhibit.
Year(s) Of Engagement Activity 2019
URL https://wellcomecollection.org/pages/XW5QMBEAACUAELBV
 
Description Metagenomic analysis of the impact of antibiotics on soil and gut bacteria, and their interaction networks 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact I was invited to give a Department Seminar at the UEA entitled "Metagenomic analysis of the impact of antibiotics on soil and gut bacteria, and their interaction networks"
Year(s) Of Engagement Activity 2019
 
Description Microbiology Society 2018 selected talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact Dr Zoe Schofield was selected to give an oral short talk talk at the annual Microbiology Society Meeting (Birmingham 2018): Bifidobacterium breve stimulates immune development in germ-free mice
Year(s) Of Engagement Activity 2018
 
Description Norwich Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Earlham Institute Bee trail at the Norwich science festival
Year(s) Of Engagement Activity 2019
URL https://norwichsciencefestival.co.uk/about/norwich-science-festival-2019/
 
Description Norwich Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Members of QIB, including from the Narbad group, were present for the whole day of a week long program. As well as discussions with participants, manning tables and displays, there were also hands-on activities, games, and crafts
Year(s) Of Engagement Activity 2019
URL https://norwichsciencefestival.co.uk/
 
Description Norwich Science Festival 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Took our Guardians of the Gut exhibit to Norwich Science festival for 2-day event (26th-27th October).
Year(s) Of Engagement Activity 2018
URL https://norwichsciencefestival.co.uk/events/science-without-borders-day/
 
Description Oral presentation at 3rd Annual Meeting of the European Virus Bioinformatics Center, Glasgow, March 28-29 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Oral presentation at scientific conference. Title Genome-resolved metaviromics for the detection of pathogenic viruses in the environment: will eating shellfish make you ill?
Year(s) Of Engagement Activity 2019
 
Description Organoid transcriptomics to study cell regulation Internal research presentation at the Earlham Institute 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Organoid transcriptomics to study cell regulation Internal research presentation at the Earlham Institute
Year(s) Of Engagement Activity 2019
 
Description Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine Stem Cells @ Lunch, a fortnightly lunchtime seminar series, hosted by Dr. Davide Danovi at the Centre for Stem Cells & Regenerative Medicine at Guy's Hospital, King's College London, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine Stem Cells @ Lunch, a fortnightly lunchtime seminar series, hosted by Dr. Davide Danovi at the Centre for Stem Cells & Regenerative Medicine at Guy's Hospital, King's College London, UK.
Year(s) Of Engagement Activity 2019
 
Description Pathway Analysis to Study the Effect of Bifidobacteria on Autophagy in the Intestine 2nd Interdisciplinary Signaling Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Pathway Analysis to Study the Effect of Bifidobacteria on Autophagy in the Intestine 2nd Interdisciplinary Signaling Workshop
Year(s) Of Engagement Activity 2017
 
Description Patient group workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact The research area and potential future directions were presented to the local hospital patient forum, in order to involve patients and public in the design of the research for a future grant proposal. There was a lot of feedback and suggestions from patients which were incorporated into the proposal, and volunteers for a future steering committee were recruited.
Year(s) Of Engagement Activity 2019
 
Description Podcast for Economist 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Podcast with the 'Economist' about the gut microbiome and celiac disease
Year(s) Of Engagement Activity 2018
 
Description Policy publication by Microbiology Society 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Contributed to the publication of the Policy document by The Microbiology society. The aim was to To help the microbiology community to consider how it might best take advantage of the opportunities stemming from microbiome research. but at the same time the document woul dbe useful to the wider audience.
Year(s) Of Engagement Activity 2018
URL https://microbiologysociety.org/policy/microbiome-policy-project/unlocking-the-microbiome-report.htm...
 
Description Poster presentation: SignaLink 3, a tissue specific and extended multi-layered signaling network resource 2nd Interdisciplinary Signalling Workshop 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Fazekas D., Kadlecsik T., Sudhakar P., Modos D., Turei D., Csabai L., Gul L., Korcsmaros T. (2017) SignaLink 3, a tissue specific and extended multi-layered signaling network resource 2nd Interdisciplinary Signalling Workshop 2017
Year(s) Of Engagement Activity 2017
URL http://signalingworkshop.org/
 
Description Public Debate 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact I was involved in a public debate at Dragons Hall in Norwich (October 2019) as part of the Norwich Science Festival. There was very strong engagement form the audience with lots of follow up questions and results for further information.
Year(s) Of Engagement Activity 2019
URL https://norwichsciencefestival.co.uk/events/dragon-hall-debates-guts/
 
Description Public Dialogue Event on Lifelong Health - gut microbes and how they interact with the food we eat to promote health 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Quadram Institute Bioscience held a public dialogue event at the new Quadram Institute when we were joined by 35 members of the public for an open discussion about gut microbes and how they interact with the food we eat to promote health. Simon Carding and Cat Edwards canvassed the group for their opinions using interactive voting technology and there was plenty of lively discussion. The event was illustrated live by Rebecca Osborne who documented the discussion, including questions and debate, in graphical form.
Topics discussed included the microbiome and its role in health and disease, the gut-brain connection, prebiotics and probiotics, faecal microbiota transplantation (FMT), healthy and diverse diets, carbohydrates, glycaemic index and our research to investigate the development of healthier food products and future foods designed to counter health problems such as Type 2 diabetes and cardiovascular disease.
Year(s) Of Engagement Activity 2019
 
Description Radio Interview for BBC Radio Norfolk 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Radio interview about our Guardians of the Gut exhibit and the microbiome - in response to the interview we had additional people visit the exhibit during the science festival
Year(s) Of Engagement Activity 2018
 
Description Royal Society Summer Exhibition 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Royal Society Summer Science Exhibition 2018 - Guardians of the Gut. Week long engagement with ~10,000 visitors.
We are fascinated about understanding how our resident gut microbes (i.e. the microbiota) impact our health, and we are particularly interested in what happens during early life. In our Guardians of the Gut exhibit we explore the amazing variety of microbes that colonise the gut right from the start, from their initial 'seeding', and where we get them from (exploring natural vs. C-section birth), and how specific types, e.g. Bifidobacterium, our favourite bacteria(!), act as Guardians of the Gut. We discuss how microbes play a key role in healthy development; helping to digest components of our food (breast or formula milk), and also how these microbes 'talk' to our immune cells. As these bacteria are so important for our wellbeing, we also explore how disturbing these early life microbial communities through e.g. antibiotics, can have short- and long-term consequences, and may predispose us to chronic diseases such as Ulcerative Colitis. Finally, we showcase some of the approaches and therapies, we and others, are developing to promote healthy early life microbial ecosystems with the aim of maintaining health and treating disease.
Year(s) Of Engagement Activity 2018
URL https://royalsociety.org/science-events-and-lectures/2018/summer-science-exhibition/exhibits/guardia...
 
Description Save Money: Good Health ITV 1 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Discussed the role of the gut microbiota on health and associated 'products' on the market including self-testing kits with Sian Williams (August 2019).
Year(s) Of Engagement Activity 2019
URL https://www.itv.com/presscentre/ep4week35/save-money-good-health
 
Description Signalling Networks: From Data to Modelling 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Contributed to a training course run at the Earlham institute entitled 'Signalling Networks: From Data to Modelling'.
Year(s) Of Engagement Activity 2019
URL https://www.earlham.ac.uk/signalling-networks-data-modelling
 
Description TV interview - BBC Look East 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact TV interview on BBC Look East about our Guardians of the Gut exhibition - people specifically attended the exhibit after they had watch the interview.
Year(s) Of Engagement Activity 2018
 
Description TV interview for Jiangsu Association for Science and Technology 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Gave TV Interview for Chinese television on the importance of my research and the value of long term collaboration with Jiangnan University in Jiangsu province.
The interview was follow of my keynote lecture at the international conference in Wuxi. The interview resulted in wider awareness in Jingsu province about the science collaboration between UK and China.
Year(s) Of Engagement Activity 2018
 
Description Teaching population genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact I was invited to the EMBL, Heidelberg, to teach a course on population genetics and participate in student discussions for EMBL first year PhD candidates.
Year(s) Of Engagement Activity 2019
 
Description Workshop presentation - Microbiome as medicine 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact An oral presentation for a BBSRC cross-institute microbiome workshop, looking to foster ideas and collaborations which could lead to novel therapeutics to treat or prevent gastrointestinal disorders/side effects. Discussions were positive and many delegates agreed that this area of research holds promise for future applications in human health
Year(s) Of Engagement Activity 2019
 
Description oral presentation in Computational Biology workshop at the Keystone Symposium on the Global Virome in Health and Disease 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact I presented my work on bacteriophage taxonomy in the context of identifying bacteriophages in microbiome data to a group of experts in viromics. The audience agreed with my assessments and have indicated they will change their practices.
Year(s) Of Engagement Activity 2020