Identification of genetic variation in innate immune response genes associated with resistance to chicken viral infections

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The overall aim is to detect and associate differences (coding and gene expression polymorphisms) within innate immune responsive genes with disease resistance of inbred lines of chickens to infection from both DNA and RNA viruses. Specific Objectives: 1) to define chicken genes and pathways that respond to viral challenge; 2) to define intron/exons, coding and promoter regions of viral response genes; 3) to define phylogenetic relationship of avian and mammalian viral response genes ; 4) to estimate dN/dS ratios for viral response genes and relate to structure/function ; 5) to define a chicken viral response gene set ; 6) to identify promoter/coding sequence polymorphisms between inbred lines ; 7) to associate polymorphisms with disease resistance in inbred lines ; 8) to identify structure/function relationships of polymorphic sites within proteins ; 9) to verify candidate promoter polymorphisms.

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