Understanding the mechanisms by which Classical Swine Fever Virus interfere with host innate immune responses
Lead Research Organisation:
THE PIRBRIGHT INSTITUTE
Department Name: UNLISTED
Abstract
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Technical Summary
CSFV is able to antagonise the antiviral effects of interferon and prevent apoptosis. The aim of this project is increase understanding of the mechanisms by which CSFV is able to avoid innate immune responses. This knowledge will be valuable for the development of intervention strategies that seek to manipulate the host’s innate immune response to prevent the virus from initiating new infections.
Planned Impact
unavailable
Organisations
People |
ORCID iD |
| Bryan Charleston (Principal Investigator) |
| Description | We have shown how an important animal virus manages to hide from the immune system and infect and spread throughout populations. |
| Exploitation Route | Development of vaccines |
| Sectors | Agriculture Food and Drink |
| Description | Develop our understanding of how viruses perturb the induction of interferon |
| First Year Of Impact | 2007 |
| Sector | Agriculture, Food and Drink |
| Impact Types | Economic |