Infectious Bursal Disease
Lead Research Organisation:
The Pirbright Institute
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The research will focus on investigating the viral gene functions and molecular pathogenic mechanisms of Infectious bursal disease virus (IBDV) infection in chickens. The project will include establishment of IBD models with IBDV strains of varying virulence in the different inbred chicken lines, development of quantitative PCR tools to measure viral replication in infected cells and laser dissection microscopic methods for analysing the cells from the infected bursal follicles. Molecular mechanisms of viral pathogenesis will be analysed by examining the dynamic changes in the global gene expression and proteome changes in avian B cells infected with IBDV.
Planned Impact
unavailable
People |
ORCID iD |
| Venugopal Nair (Principal Investigator) |
Publications
Farhanah MI
(2018)
Bursal transcriptome profiling of different inbred chicken lines reveals key differentially expressed genes at 3 days post-infection with very virulent infectious bursal disease virus.
in The Journal of general virology
Mohd Isa F
(2020)
Differential expression of immune-related genes in the bursa of Fabricius of two inbred chicken lines following infection with very virulent infectious bursal disease virus.
in Comparative immunology, microbiology and infectious diseases
Sadigh Y
(2018)
Gallid herpesvirus 3 SB-1 strain as a recombinant viral vector for poultry vaccination.
in NPJ vaccines
| Description | Avian Vaccines Malaysian Researchers |
| Organisation | Putra Malaysia University |
| Department | Department of Pathology |
| Country | Malaysia |
| Sector | Hospitals |
| PI Contribution | We have successfully organized a British Council funded workshop on Emerging and Next Generation Vaccine Technologies Against Veterinary Viruses at Institute of Bioscience (IBS), Universiti Putra Malaysia from 01 to 04 August 2016. |
| Collaborator Contribution | Through this partnership, we have applied two research grants to work together in tackling infections in poultry. |
| Impact | Two Funding Applied One Publication Online |
| Start Year | 2016 |
| Description | Research Collaboration with UPM Malaysia |
| Organisation | Putra Malaysia University |
| Country | Malaysia |
| Sector | Academic/University |
| PI Contribution | this was to work on virus host interactions in infectious bursal disease virus infection. We prepared the infected samples and RNA sent to them for sequence analysis |
| Collaborator Contribution | Partners carried out RNAseq analysis as part of a PhD studentship which V Nair was the supervisor. |
| Impact | A paper on the work is currently under review |
| Start Year | 2011 |
| Description | AN INTERVIEW WITH PROFESSOR VENUGOPAL NAIR |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Professor Venugopal Nair is a Research Group Leader at The Pirbright Institute, a visiting Professor of Avian Virology at the Department of Zoology, and a Jenner Investigator at the Jenner Institute, University of Oxford. He is also a member of the Microbiology Society, and in this interview, he tells us more about his research into viral diseases of livestock. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://microbiologysociety.org/membership/meet-our-members/focus-area-viruses/an-interview-with-pro... |