RNA virus Evolution

Lead Research Organisation: The Pirbright Institute
Department Name: UNLISTED

Abstract

RNA viruses are genetically very diverse. They quickly emerge and evolve with high mutation rates, large population sizes, and short generation times. This fellowship aims to increase understanding of genetic and phenotypic characteristics that impact upon RNA virus evolvability. Focusing in the first instance on Foot-and-mouth disease virus, the project will investigate the limits of genetic variability at a consensus level. The evolution of the consensus sequence shall also be investigated using the power of next generation sequencing technologies. Complementary to this, in vitro experiments will be undertaken in order to understand how genetic diversity is generated within a cell, and how this impacts upon virus fitness.
 
Description RNA viruses are highly adept at evolving (through genetic mutation and selection) to take advantage of new environmental niches and to escape host immunity and antiviral activity. This fellowship post investigated technical and analytical approaches that can be applied to address questions relating the RNA virus evolution.
Exploitation Route This fellowship is now completed
Sectors Education

 
Description OIE/FAO Laboratory Network for FMD 
Organisation Botswana Vaccine Institute
Country Botswana 
Sector Public 
PI Contribution The Pirbright Institute currently coordinates a global network of fourteen International Reference Laboratories for FMD.
Collaborator Contribution The Network of OIE/FAO FMD Reference Laboratories has been established with two principal goals: 1) To understand global virus distribution patterns and use these data to inform vaccine recommendations and 2) To harmonise and improve the quality of laboratory testing carried out by international and national reference laboratories. These activities require sharing and joint evaluation of surveillance information from laboratory diagnosis, serotyping, genetic characterisation and vaccine matching tests and harmonisation of standards for diagnostic procedures.
Impact Outputs from the network provide vital information to international organisations involved in the control of FMD (such as OIE and FAO), as well as specific regional and national programmes to control FMD
Start Year 2006
 
Description OIE/FAO Laboratory Network for FMD 
Organisation Department of Livestock Development
Country Thailand 
Sector Public 
PI Contribution The Pirbright Institute currently coordinates a global network of fourteen International Reference Laboratories for FMD.
Collaborator Contribution The Network of OIE/FAO FMD Reference Laboratories has been established with two principal goals: 1) To understand global virus distribution patterns and use these data to inform vaccine recommendations and 2) To harmonise and improve the quality of laboratory testing carried out by international and national reference laboratories. These activities require sharing and joint evaluation of surveillance information from laboratory diagnosis, serotyping, genetic characterisation and vaccine matching tests and harmonisation of standards for diagnostic procedures.
Impact Outputs from the network provide vital information to international organisations involved in the control of FMD (such as OIE and FAO), as well as specific regional and national programmes to control FMD
Start Year 2006
 
Description OIE/FAO Laboratory Network for FMD 
Organisation FGBI Federal Centre for Animal Health
Country Russian Federation 
Sector Public 
PI Contribution The Pirbright Institute currently coordinates a global network of fourteen International Reference Laboratories for FMD.
Collaborator Contribution The Network of OIE/FAO FMD Reference Laboratories has been established with two principal goals: 1) To understand global virus distribution patterns and use these data to inform vaccine recommendations and 2) To harmonise and improve the quality of laboratory testing carried out by international and national reference laboratories. These activities require sharing and joint evaluation of surveillance information from laboratory diagnosis, serotyping, genetic characterisation and vaccine matching tests and harmonisation of standards for diagnostic procedures.
Impact Outputs from the network provide vital information to international organisations involved in the control of FMD (such as OIE and FAO), as well as specific regional and national programmes to control FMD
Start Year 2006
 
Description OIE/FAO Laboratory Network for FMD 
Organisation French Agency for Food, Environmental and Occupational Health & Safety (ANSES)
Country France 
Sector Public 
PI Contribution The Pirbright Institute currently coordinates a global network of fourteen International Reference Laboratories for FMD.
Collaborator Contribution The Network of OIE/FAO FMD Reference Laboratories has been established with two principal goals: 1) To understand global virus distribution patterns and use these data to inform vaccine recommendations and 2) To harmonise and improve the quality of laboratory testing carried out by international and national reference laboratories. These activities require sharing and joint evaluation of surveillance information from laboratory diagnosis, serotyping, genetic characterisation and vaccine matching tests and harmonisation of standards for diagnostic procedures.
Impact Outputs from the network provide vital information to international organisations involved in the control of FMD (such as OIE and FAO), as well as specific regional and national programmes to control FMD
Start Year 2006
 
Description OIE/FAO Laboratory Network for FMD 
Organisation Lanzhou Veterinary Research Institute
Country China 
Sector Learned Society 
PI Contribution The Pirbright Institute currently coordinates a global network of fourteen International Reference Laboratories for FMD.
Collaborator Contribution The Network of OIE/FAO FMD Reference Laboratories has been established with two principal goals: 1) To understand global virus distribution patterns and use these data to inform vaccine recommendations and 2) To harmonise and improve the quality of laboratory testing carried out by international and national reference laboratories. These activities require sharing and joint evaluation of surveillance information from laboratory diagnosis, serotyping, genetic characterisation and vaccine matching tests and harmonisation of standards for diagnostic procedures.
Impact Outputs from the network provide vital information to international organisations involved in the control of FMD (such as OIE and FAO), as well as specific regional and national programmes to control FMD
Start Year 2006
 
Description OIE/FAO Laboratory Network for FMD 
Organisation Lombardy and Emilia Romagna Experimental Zootechnic Institute (IZSLER)
Country Italy 
Sector Public 
PI Contribution The Pirbright Institute currently coordinates a global network of fourteen International Reference Laboratories for FMD.
Collaborator Contribution The Network of OIE/FAO FMD Reference Laboratories has been established with two principal goals: 1) To understand global virus distribution patterns and use these data to inform vaccine recommendations and 2) To harmonise and improve the quality of laboratory testing carried out by international and national reference laboratories. These activities require sharing and joint evaluation of surveillance information from laboratory diagnosis, serotyping, genetic characterisation and vaccine matching tests and harmonisation of standards for diagnostic procedures.
Impact Outputs from the network provide vital information to international organisations involved in the control of FMD (such as OIE and FAO), as well as specific regional and national programmes to control FMD
Start Year 2006
 
Description OIE/FAO Laboratory Network for FMD 
Organisation National Agri-Food Quality and Health Service (SENASA)
Country Argentina 
Sector Public 
PI Contribution The Pirbright Institute currently coordinates a global network of fourteen International Reference Laboratories for FMD.
Collaborator Contribution The Network of OIE/FAO FMD Reference Laboratories has been established with two principal goals: 1) To understand global virus distribution patterns and use these data to inform vaccine recommendations and 2) To harmonise and improve the quality of laboratory testing carried out by international and national reference laboratories. These activities require sharing and joint evaluation of surveillance information from laboratory diagnosis, serotyping, genetic characterisation and vaccine matching tests and harmonisation of standards for diagnostic procedures.
Impact Outputs from the network provide vital information to international organisations involved in the control of FMD (such as OIE and FAO), as well as specific regional and national programmes to control FMD
Start Year 2006
 
Description OIE/FAO Laboratory Network for FMD 
Organisation National Centre for Foreign Animal Diseases (NCFAD)
Country Canada 
Sector Public 
PI Contribution The Pirbright Institute currently coordinates a global network of fourteen International Reference Laboratories for FMD.
Collaborator Contribution The Network of OIE/FAO FMD Reference Laboratories has been established with two principal goals: 1) To understand global virus distribution patterns and use these data to inform vaccine recommendations and 2) To harmonise and improve the quality of laboratory testing carried out by international and national reference laboratories. These activities require sharing and joint evaluation of surveillance information from laboratory diagnosis, serotyping, genetic characterisation and vaccine matching tests and harmonisation of standards for diagnostic procedures.
Impact Outputs from the network provide vital information to international organisations involved in the control of FMD (such as OIE and FAO), as well as specific regional and national programmes to control FMD
Start Year 2006
 
Description OIE/FAO Laboratory Network for FMD 
Organisation Onderstepoort Veterinary Institute
Country South Africa 
Sector Academic/University 
PI Contribution The Pirbright Institute currently coordinates a global network of fourteen International Reference Laboratories for FMD.
Collaborator Contribution The Network of OIE/FAO FMD Reference Laboratories has been established with two principal goals: 1) To understand global virus distribution patterns and use these data to inform vaccine recommendations and 2) To harmonise and improve the quality of laboratory testing carried out by international and national reference laboratories. These activities require sharing and joint evaluation of surveillance information from laboratory diagnosis, serotyping, genetic characterisation and vaccine matching tests and harmonisation of standards for diagnostic procedures.
Impact Outputs from the network provide vital information to international organisations involved in the control of FMD (such as OIE and FAO), as well as specific regional and national programmes to control FMD
Start Year 2006
 
Description OIE/FAO Laboratory Network for FMD 
Organisation Pan American Foot-and-Mouth Disease Center (Panaftosa)
Country Brazil 
Sector Charity/Non Profit 
PI Contribution The Pirbright Institute currently coordinates a global network of fourteen International Reference Laboratories for FMD.
Collaborator Contribution The Network of OIE/FAO FMD Reference Laboratories has been established with two principal goals: 1) To understand global virus distribution patterns and use these data to inform vaccine recommendations and 2) To harmonise and improve the quality of laboratory testing carried out by international and national reference laboratories. These activities require sharing and joint evaluation of surveillance information from laboratory diagnosis, serotyping, genetic characterisation and vaccine matching tests and harmonisation of standards for diagnostic procedures.
Impact Outputs from the network provide vital information to international organisations involved in the control of FMD (such as OIE and FAO), as well as specific regional and national programmes to control FMD
Start Year 2006
 
Description OIE/FAO Laboratory Network for FMD 
Organisation Project Directorate on Foot and Mouth Disease
Country India 
Sector Public 
PI Contribution The Pirbright Institute currently coordinates a global network of fourteen International Reference Laboratories for FMD.
Collaborator Contribution The Network of OIE/FAO FMD Reference Laboratories has been established with two principal goals: 1) To understand global virus distribution patterns and use these data to inform vaccine recommendations and 2) To harmonise and improve the quality of laboratory testing carried out by international and national reference laboratories. These activities require sharing and joint evaluation of surveillance information from laboratory diagnosis, serotyping, genetic characterisation and vaccine matching tests and harmonisation of standards for diagnostic procedures.
Impact Outputs from the network provide vital information to international organisations involved in the control of FMD (such as OIE and FAO), as well as specific regional and national programmes to control FMD
Start Year 2006
 
Description OIE/FAO Laboratory Network for FMD 
Organisation U.S. Department of Agriculture USDA
Department Agricultural Research Service
Country United States 
Sector Public 
PI Contribution The Pirbright Institute currently coordinates a global network of fourteen International Reference Laboratories for FMD.
Collaborator Contribution The Network of OIE/FAO FMD Reference Laboratories has been established with two principal goals: 1) To understand global virus distribution patterns and use these data to inform vaccine recommendations and 2) To harmonise and improve the quality of laboratory testing carried out by international and national reference laboratories. These activities require sharing and joint evaluation of surveillance information from laboratory diagnosis, serotyping, genetic characterisation and vaccine matching tests and harmonisation of standards for diagnostic procedures.
Impact Outputs from the network provide vital information to international organisations involved in the control of FMD (such as OIE and FAO), as well as specific regional and national programmes to control FMD
Start Year 2006
 
Description OIE/FAO Laboratory Network for FMD 
Organisation Veterinary and Agrochemical Research Centre
Country Belgium 
Sector Public 
PI Contribution The Pirbright Institute currently coordinates a global network of fourteen International Reference Laboratories for FMD.
Collaborator Contribution The Network of OIE/FAO FMD Reference Laboratories has been established with two principal goals: 1) To understand global virus distribution patterns and use these data to inform vaccine recommendations and 2) To harmonise and improve the quality of laboratory testing carried out by international and national reference laboratories. These activities require sharing and joint evaluation of surveillance information from laboratory diagnosis, serotyping, genetic characterisation and vaccine matching tests and harmonisation of standards for diagnostic procedures.
Impact Outputs from the network provide vital information to international organisations involved in the control of FMD (such as OIE and FAO), as well as specific regional and national programmes to control FMD
Start Year 2006
 
Description CEEZAD BSL-3 Training/Transboundary Animal Disease Summer Program - Manhattan, Kansas, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact CEEZAD BSL-3 Training/Transboundary Animal Disease Summer Program Provides a Unique Opportunity for Future Veterinary Professionals

Ten future veterinary professionals with an interest in transboundary disease research took part in a two-week training program conducted by the Center of Excellence for Emerging Zoonotic and Animal Diseases (CEEZAD) at Kansas State University in coordination with the Kansas State University Biosecurity Research Institute (BRI).

The program involved one week of exposure to operations, safety techniques and lab principles of high-containment BSL-3 work at the Biosecurity Research Institute at Kansas State University followed by a second week of visits to institutions involved in the animal health industry and lectures. Students, representing 10 universities from around the USA, heard from prominent professionals in the area of zoonotic and transboundary disease research. The participants include students in veterinary medicine, doctoral students and post-DVM residents
Year(s) Of Engagement Activity 2016
URL http://ceezad.org/news_events/
 
Description Invited Seminar - Transboundary Seminar Series 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Contributed a talk to the transboundary seminar series hosted by the Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD) at Kansas State University, USA. The title of the talk was "Who infected who? - the use of sequence data to reconstruct transmission pathways in FMD outbreaks" - and described insights from our work on the evolutionary biology of FMD.
Year(s) Of Engagement Activity 2016
 
Description Invited Talk - 17th International Symposium of the World Association of Veterinary Laboratory Diagnosticians, Saskatoon, Canada, June 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited Talk: King D. P., Valdazo-González B., Freimanis G., King D. J., Wright C. F., Di Nardo A., Wadsworth J., Soubeyrand S., Knowles N. J., Kim J. and Haydon D. T. The challenges of linking genetic and epidemiological datasets to reconstruct transmission trees for livestock viral diseases. OIE Symposium at the 17th International Symposium of the World Association of Veterinary Laboratory Diagnosticians, Saskatoon, Canada, June 2015.
Year(s) Of Engagement Activity 2015
 
Description Keynote presentation - 7th International Symposium on Emerging and re-emerging Pig Diseases, Kyoto, Japan 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented a talk outlining our research findings - entitled: "King D.P., Logan G., Freimanis G. L., Wright C. F., King D. J., Knowles N. J., Wadsworth J., Lasecka L., Bachanek-Bankowska K., Di Nardo A., Orton R. and Haydon D. T. Using sequence data to understand the epidemiology of foot-and-mouth disease" at the 7th International Symposium on Emerging and re-emerging Pig Diseases, Kyoto, Japan, June 2015.
Year(s) Of Engagement Activity 2015
URL http://emerging2015.com