Viral transmission by insect vectors

Lead Research Organisation: The Pirbright Institute
Department Name: UNLISTED

Abstract

Understanding how viruses are transmitted is fundamental to controlling and ultimately eradicating a disease. This is particularly true for viruses with biological vectors where the life cycle of the virus often relies on the vector species, presenting more opportunities for disease control. Pirbright has an excellent track record in using biological data to inform models of transmission that directly inform policy on vaccination and culling. Moreover we have world leading facilities and expertise in studying insect vectors, including mosquitoes and midges, and their capacity to transmit viruses that cause disease. This unique combination allows Pirbright to react quickly to emerging threats, and we are alone in the UK in our ability to undertake fundamental basic research in an authentic disease context with the insect vector and the vertebrate disease host.
Arboviruses (arthropod-borne viruses) have a medical and veterinary impact in both developing and developed countries worldwide. Pirbright studies arbovirus transmission using state-of-the-art containment facilities paired with a cadre of specialist scientists and a track record that extends to over forty years of research in this area. Using these resources we will investigate factors that drive the emergence, spread and persistence of arboviruses in the wider environment with an emphasis on providing environmentally sound counter-measures for the control of disease. Our primary research targets will be Culicoides biting midges and mosquitoes. Culicoides are the most important vectors of livestock arboviruses in Europe, transmitting bluetongue and Schmallenberg viruses, while mosquito-borne arboviruses, such as dengue virus, incapacitate and kill more people each year than those transmitted by any other vector family.
We will examine the genetic and environmental drivers that enable arthropods to act as vectors of arboviruses with an emphasis on providing a range of tools that can be used to predict the probability of transmission. The specific methods used to study these vector groups will vary depending on the development and availability of key biological resources (e.g. suitable laboratory colonies; transcriptomes and genomes; associated cell lines) and informed by our existing track record, including working in high containment facilities. While in some arthropods (e.g. important mosquito vectors such as Aedes aegypti) these resources are vast and allow comparatively straightforward application of emerging technologies, other groups, in particular Culicoides are less tractable, largely due to the inability to produce relevant laboratory colony lines. Our aim is to provide a balanced approach that includes both cutting edge research of well characterised species of vector in the laboratory, combined with experiments based around less well characterised species of vector in the field. A major component of vector capacity is the ability of the arthropod to develop a transmissible infection with an arbovirus and will be a major focus of research within the ISP.
Arthropod vectors such as mosquitoes and Culicoides can provide highly efficient dispersal and transmission vehicles for viruses, but also provide a potential target for intervention. In this objective we will develop novel approaches to understanding and interrupting virus transmission by arthropods. We will target vectorial capacity both by developing means to reduce the number of vectors (“population suppression” methods) and through reducing individual vector competence (“refractory insects”). We will take a synthetic biology approach, using standardised approaches and sub-sections of the entire procedure to shorten each phase of the design-test-build cycle, and to produce more robust and flexible designs and genetic circuits. Despite the importance of arboviruses and their vectors, our understanding of critical aspects of vector biology remains poor, even for the most high-profile vector species. Similarly, arbovirus studies focus overwhelmingly on interaction with the vertebrate host, rather than with the arthropod. Work under this objective therefore comprises an integrated programme identifying and addressing specific knowledge gaps in fundamental understanding, as well as using current and project-derived tools and knowledge to assemble functional genetic circuits and systems for control.

Publications

10 25 50
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Antonovics J (2017) The evolution of transmission mode. in Philosophical transactions of the Royal Society of London. Series B, Biological sciences

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Brugman VA (2018) The Role of Culex pipiens L. (Diptera: Culicidae) in Virus Transmission in Europe. in International journal of environmental research and public health

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Brugman VA (2018) Bird-biting mosquitoes on farms in southern England. in The Veterinary record

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Cable J (2017) Global change, parasite transmission and disease control: lessons from ecology. in Philosophical transactions of the Royal Society of London. Series B, Biological sciences

 
Description The Viral Transmission by Insect Vectors ISPG component grant has two primary objectives: (1) to examine the influence of vector competence in the spread of arboviruses and (2): To develop new tools for controlling the spread of viruses by arthropod vectors. In the two years of funding to date we have carried out an animal experiment that has demonstrated that reduced vector competence has led to reduced spread of a re-emerging bluetongue virus (BTV) strain in northern Europe (1) and additionally showed that UK populations of Culicoides showed greater vector competence for Schmallenberg virus (SBV) than for BTV strains (1). The latter observation helps explain the differential spread for SBV which reached the UK more rapidly from outbreaks on the continent. We have also conducted both reviews and meetings that have promoted the use of standardised approaches for testing vector competence - lack of such standardisation has been a major issue in comparative analysis of studies. These culminated in several meetings around this subject area and surveys across the vector-borne diseases community. We are also in the process of improving genomic resources for the study of Culicoides in addition to identifying a suite of genes associated with infection with arboviruses (1,2). New promoters driving gene expression in Anopheles gambiae embryos identified, isolated and validated in in vivo activity tests. Based on the above finding, a number of A. gambiae strains generated that produce heavily male-biased or male-only progenies (2). The aim of these studies is to be able to mass produce mosquitoes as male-only populations which will facilitate the substantial releases of individuals required during control attempts in the field. These studies have been complemented by publications examining the role that gene drives might play in the control and eradication of mosquito populations (2). One paper focussed on the population dynamics of engineered underdominance and killer-rescue gene drives in the control of disease vectors (2). These systems are in the middle range of invasive drives and represent a method to mitigate key regulatory and environmental concerns. Finally, we have carried out preliminary studies examining the lumpy skin disease virus that have demonstrated that mechanical transmission by arthropods may play a major role in virus spread (1). To date this ISPG project has resulted in the publication of 24 publications and over 100 engagement activities, in addition to providing evidence used in governmental assessments of genetic modification techniques and the impact of climate change on vector-borne diseases.
Exploitation Route Each of the key findings will be pursued further within this ongoing grant. We will further characterize Culicoides vector competence and the genetic basis thereof. We will continue to develop strategies for introgressing exogenous genes into wild vector populations - a method with considerable potential application for human health, agriculture and conservation - and the necessary molecular and genetic components and methods for that. We will follow up preliminary studies on lumpy skin disease to further characterize transmission, especially the potential role of insect vectors. Information and material outputs from these studies will be of considerable interest to the respective stakeholders.
Sectors Agriculture, Food and Drink,Environment,Pharmaceuticals and Medical Biotechnology

 
Description BBSRC-Newton Fund Agricultural Data Re-use Advisory Group
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Advice on re-usability of data generated in research projects.
 
Description Contributed to Chief Medical Officers report- Genomics section
Geographic Reach Europe 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
URL https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/6310...
 
Description Contribution to Annual Report of the Chief Medical Officer UK (2017), Genomics Chapter 9.
Geographic Reach Europe 
Policy Influence Type Gave evidence to a government review
 
Description Contribution to guidance document "Safe working with arthropods: Containment and control for work with uninfected, infected and transgenic animals in research"
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact Contributed to a document providing the first detailed guidance by the relevant national professional body (ISTR, the Institute for Safety in Technology and Research) on compliance with HSE requirements for working with exotic, GM and infected arthropods.
URL https://www.pirbright.ac.uk/news/2017/04/first-industry-guidance-safe-working-arthropods-and-gm-inse...
 
Description EFSA working group on lumpy skin disease
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact Report to the European Commission on the spread and control of lumpy skin disease in the Balkans
URL http://www.efsa.europa.eu/en/efsajournal/pub/5176
 
Description EFSA working group on lumpy skin disease
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact Advice to European Commission and affected countries about control and surveillance for lumpy skin disease
URL https://efsa.onlinelibrary.wiley.com/doi/full/10.2903/j.efsa.2018.5452
 
Description EFSA working group on lumpy skin disease
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact The models developed to describe the spread of lumpy skin disease virus (LSDV) within and between farms have been used to inform disease control policy following incursion of LSDV to south-eastern Europe. Specifically, the models were used to assess the impact of vaccination on disease spread. They were also used to investigate the duration of a vaccination campaign to prevent re-emergence of LSDV and to help design surveillance programmes to detect the re-emergence of the virus or its re-introduction from neighbouring countries. The results have been communicated to the European Commission and to affected countries via the European Food Safety Authority.
URL https://efsa.onlinelibrary.wiley.com/doi/full/10.2903/j.efsa.2018.5452
 
Description IUCN Technical Subgroup on Synthetic Biology and Biodiversity Conservation
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Netherlands Commission on Genetic Modification (COGEM) Project "Gene drives, inventory of previous research and experience"
Geographic Reach Europe 
Policy Influence Type Gave evidence to a government review
 
Description Organised seminar series on Sequencing, Virus Evolution and Molecular Biology at Pirbright (with Luca Ferretti and Graham Freimanis)
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
 
Description POSTnote Report on Climate and vector-diseases in humans in the UK
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description RCUK Engagement workshop, Cosener's House, 20-21 April 2017
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description SACGM(CU) member 2014-present
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact The Scientific Advisory Committee on Genetic Engineering (Contained Use), SACGM(CU), provides technical and scientific advice to HSE and Ministers for the Department for Environment, Food and Rural Affairs, as well as their counterparts in Scotland, Wales and Northern Ireland. It has been in existence since 2004; I have been a member since 2014
URL https://webcommunities.hse.gov.uk/connect.ti/SACGM/grouphome
 
Description BBSRC GCRF Impact Accelerator Award
Amount £5,000 (GBP)
Funding ID BB/GCRF-IAA/17/16 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2018 
End 02/2018
 
Description BBSRC Responsive Mode IPA
Amount £302,086 (GBP)
Funding ID BB/R002606/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2018 
End 06/2019
 
Description Biotechnology and Biological Sciences Research Council (BBSRC) and University of Oxford joint Doctoral Training Project
Amount £100,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2018 
End 08/2022
 
Description Components of the Medea gene drive system in a mosquito Aedes aegypti
Amount £1,209,348 (GBP)
Funding ID BB/S001964/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 11/2018 
End 10/2021
 
Description DARPA PREEMPT
Amount $2,700,000 (USD)
Organisation Defense Advanced Research Projects Agency (DARPA) 
Sector Public
Country United States
Start 10/2018 
End 03/2022
 
Description GCRF Networks in Vector Ecology
Amount £1,035,634 (GBP)
Funding ID BB/R005362/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 07/2017 
End 06/2020
 
Description H2020 work programme topic 9 Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy, work topic SFS-10-2017 Research and approaches for emerging diseases in plants and terrestrial livestock
Amount € 5,986,250 (EUR)
Organisation European Commission H2020 
Sector Public
Country Belgium
Start 05/2018 
End 04/2023
 
Description International Workshops
Amount £10,000 (GBP)
Funding ID BB/R021198/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 05/2018 
End 05/2019
 
Title GCRF portal on transboudary diseases 
Description The Integrative Biology and Bioinformatics group is developing a GCRF-funded Portal on Transboundary Diseases. It will be an easy way for all scientists, and those from LMI countries in particular, to access data about several viral diseases generated at Pirbright. The portal will be country-based, presenting the user with a map and dispatching them to the information relevant to the selected region. From that information the user will be able to reach specialised websites for diseases present in the country, and data generated at Pirbright (such as sequences for FMDV, several Capripox viruses, and ASFV). Sequences relevant to the portal are currently being generated. Bioinformatics workflows are hosted on the IBB cluster, and have been implemented as REST web services so as to be decoupled from the web interface. The web interface is currently being developed with the help of a specialised company. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? No  
Impact The portal will benefit scientists from LMI countries, and all scientist, allowing them to access/download genetic and other data relevant to animal diseases present in a country of choice and studied and Pirbright. Some of the data (for instance the FMDV data generated by the World Reference Lab) is already use to inform policy at international level. Being able to access information in a systematic way will increase the potential for it to be put to good use. 
 
Title Genome browser for mosquitos at different developmental stages 
Description The database integrates and makes available the results of the bioinformatics analysis of several experiments involving high-throughput sequencing of mosquito cells at different developmental stages generated within the Vector-borne Viral Disease group at the Pirbright Institute. 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact The genome browser allows the researchers to meaningfully mine and integrate the large amount of data produced by their experiments, guiding subsequent experimental hypothesis-driven validation in the lab. 
 
Title Viral assembly pipeline 
Description The Integrative Biology and Bioinformatics group has developed a data analysis pipeline to obtain sensitive and robust viral assemblies out of high-throughput sequencing data. In spite of the relatively short genomic length of most viruses, assembling of viral sequences can be challenging due to several reasons, such as: low amount of material in the sample, which might require amplification, introducing biases, and/or generates low-quality sequences; uneven coverage due to low-quality material or the genomic material of the virus being RNA; the viral nucleic acid being almost lost in the background of nucleic acid of the host. Our pipeline overcomes most of those problems, and is even able to detect different viral strains being present together in the same sample. It can also be used on metagenomic environmental samples. 
Type Of Material Data analysis technique 
Year Produced 2017 
Provided To Others? No  
Impact The pipeline is being deployed as the tool of choice for the nascent sequencing facility at Pirbright. It has been used by several groups at Pirbright, and the FMDV World Reference Lab, in order to assemble very different kinds of viruses. 
 
Title Viral variant calling pipeline 
Description The Integrative Biology and Bioinformatics group has developed a data analysis pipeline to obtain sensitive and robust variant calling for viral sequences out of high-throughput sequencing data. In spite of the relatively short genomic length of most viruses, calling variant for viral sequences can be challenging due to several reasons, such as: low amount of material in the sample, which might require amplification, introducing biases, and/or generates low-quality sequences; very high genome coverage, which slows down most existing variant callers; the presence of a potentially very high number of different haplotypes for RNA viruses, which is an unusual scenario in variant calling. Our fast and sensitive Bayesian pipeline overcomes most of those problems. 
Type Of Material Data analysis technique 
Year Produced 2017 
Provided To Others? No  
Impact The pipeline is being deployed as the tool of choice for the nascent sequencing facility at Pirbright. It has been used by several groups at Pirbright, and the FMDV World Reference Lab, in order to assemble very different kinds of viruses. 
 
Description Anopheles reannotation 
Organisation Centre for Genomic Regulation (CRG)
Country Spain 
Sector Academic/University 
PI Contribution Provided RNA-sequencing data (produced by Jaroslaw Krzywinski and analysed by us)
Collaborator Contribution Using the data to produce a reannotation of Anopheles Gambiae
Impact No outputs yet
Start Year 2017
 
Description BBSRC-UC Davis workshop, 16-18 October 
Organisation University of California, Davis
Department UC Davis College of Biological Sciences
Country United States 
Sector Academic/University 
PI Contribution Presented on "Reproducibility and relevance in vector infection studies". Followed up with discussion of potential publication and funding opportunities.
Collaborator Contribution Various presentations on vectors and vector-borne diseases including, facilities, challenges, opportunities.
Impact Discussion of potential joint publications and grant applications; no tangible impacts yet.
Start Year 2017
 
Description BBSRC-UC Davis workshop, 16-18 October 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Presented on "Reproducibility and relevance in vector infection studies". Followed up with discussion of potential publication and funding opportunities.
Collaborator Contribution Various presentations on vectors and vector-borne diseases including, facilities, challenges, opportunities.
Impact Discussion of potential joint publications and grant applications; no tangible impacts yet.
Start Year 2017
 
Description Components of the Medea gene drive system in a mosquito Aedes aegypti 
Organisation National Health Research Institutes (NHRI) Taiwan
Department Institute of Molecular and Genomic Medicine
Country Taiwan, Province of China 
Sector Charity/Non Profit 
PI Contribution Developed joined research project and lead successful application for funding
Collaborator Contribution Various lines of research, including construction of plasmids and development and characterisation of transgenic mosquito strains; and group discussions about results, conclusions and research progress.
Impact No impact yet.
Start Year 2018
 
Description Components of the Medea gene drive system in a mosquito Aedes aegypti 
Organisation National Institute of Genetics
Department NIG-FLY, Mishima (Drosophila RNAi resources)
Country Japan 
Sector Public 
PI Contribution Developed joined research project and lead successful application for funding
Collaborator Contribution Various lines of research, including construction of plasmids and development and characterisation of transgenic mosquito strains; and group discussions about results, conclusions and research progress.
Impact No impact yet.
Start Year 2018
 
Description Engineering mosquitoes for reduced vector competence for chikungunya virus 
Organisation University of Malaya
Department Department of Medical Microbiology
PI Contribution Developed joint research programme, led successful application for funding, coordinate programme.
Collaborator Contribution Various specific strands of research, and group discussions about results, conclusions, research progress and future activities.
Impact reported under funding
Start Year 2016
 
Description Engineering mosquitoes for reduced vector competence for chikungunya virus 
Organisation University of Melbourne
Country Australia 
Sector Academic/University 
PI Contribution Developed joint research programme, led successful application for funding, coordinate programme.
Collaborator Contribution Various specific strands of research, and group discussions about results, conclusions, research progress and future activities.
Impact reported under funding
Start Year 2016
 
Description Engineering mosquitoes for reduced vector competence for chikungunya virus 
Organisation University of Tartu
Department Institute of Technology
PI Contribution Developed joint research programme, led successful application for funding, coordinate programme.
Collaborator Contribution Various specific strands of research, and group discussions about results, conclusions, research progress and future activities.
Impact reported under funding
Start Year 2016
 
Description ILRI Research Collaboration (Kenya, March 2017) 
Organisation International Livestock Research Institute (ILRI)
Country Kenya 
Sector Charity/Non Profit 
PI Contribution Exchange of ideas and samples for indigenous breeds of livestock
Collaborator Contribution Contributed samples for analysis.
Impact Analysis of indigenous breed genomic sequences for Immune function genes.
Start Year 2017
 
Description Microbial products in insect saliva and effects on virus infection enhancement 
Organisation Boston University School of Medicine
PI Contribution Sharing of results on the discovery of bacterial LPS in Culicoides saliva and its infection enhancing effect on BTV in bovine monocytes. Discussion of future work and comparison of the results to other insect transmitted viruses including those of high importance to humans
Collaborator Contribution Sharing of data from their portfolio on mosquito saliva effects on virus infectivity and replication. Comparison of methodology and discussion of future collaborations
Impact On-going sharing of results and discussion of future experiments
Start Year 2018
 
Description Reannotation of the Anopheles gambiae genome 
Organisation Centre for Genomic Regulation (CRG)
Country Spain 
Sector Academic/University 
PI Contribution Generated and provided RNA-seq data from the developmental transcriptome of the mosquito Anopheles gambiae
Collaborator Contribution Conducting reannotation of the Anopheles gambiae genome based on RNA-seq data from the developmental transcriptome
Impact No outputs yet
Start Year 2017
 
Description Semiochemical-based detection of arboviral infection 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Preliminary data collection on the influence of arboviral infection on semiochemical output from sheep. These studies are being conducted as part of an unrelated animal experiment within the isolation units at Pirbright. We are carrying out the animal-based studies and collecting air entrainments from animals both pre- and post-infection. These are then decontaminated for movement to LSHTM.
Collaborator Contribution LSHTM are carrying out analysis of air entrainments using GC-MS. They will assess differences in profiles of infected vs uninfected animals and report their findings to us.
Impact Still ongoing.
Start Year 2018
 
Description Semliki Forest 
Organisation The Pirbright Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Generated and analysed RNA-sequencing samples with bespoke in-house methods
Collaborator Contribution Generated samples
Impact The purpose of the collaboration is to study how arboviruses interact with their host cells with modern high-throughput techniques. No outputs yet
Start Year 2017
 
Description 360 degree Lab Animal Tour (and film) of The Plowright Building, The Philip Mellor Insectary, and Animal Isolation Facilities 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The website provides unique access to the animal research facilities at The Pirbright Institute which support its world-leading scientific research into livestock viral diseases and helps save countless animal and potentially human lives, globally. Produced and filmed by Understanding Animal Research, the Lab Animal Tour was filmed at Pirbright, and at three other research centres, and provides the viewer with an interactive 360 virtual tour of the animal facilities.
Year(s) Of Engagement Activity 2017
URL http://www.labanimaltour.org/pirbright
 
Description AB Improving Approaches to Prevent and Control Viral Diseases of Livestock and Poultry 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Batra, A., Maier, H.J., Britton P., Hiscox, J.A., Fife, M.S., 2015. PI3K/AKT signalling during infectious bronchitis virus infection. Food Security: Improving Approaches to Prevent and Control Viral Diseases of Livestock and Poultry, British Council Research Links Workshop, Istanbul, Turkey (Oral presentation)
Year(s) Of Engagement Activity 2015
 
Description AB Society of General Microbiology Annual conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Poster presentation. Batra, A., Maier, H.J., Britton, P., Hiscox, J.A., Fife, M.S. AKT activation during infectious bronchitis virus infection. Society of General Microbiology Annual conference, Liverpool, UK
Year(s) Of Engagement Activity 2013,2014,2015
 
Description Amy Lewis, The Scientist, 15/08/2017 re gene drive and Predator Free NZ 2050 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Provided information and quotes for article on potential use of gene drives as part of New Zealand effort to eradicate invasive predators
Year(s) Of Engagement Activity 2017
URL https://www.the-scientist.com/?articles.view/articleNo/50180/title/Driving-Down-Pests/
 
Description Ash Manor GCSE Mentoring 2018 - BA 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description BBC Today programme 24/01/2019 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Interview on BBC Today programme regarding potential development and use of gene drives in mice
Year(s) Of Engagement Activity 2019
URL https://www.bbc.co.uk/sounds/play/m00025bt
 
Description BBSRC website article: Halloween 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article on BBSRC website: Halloween Creepy Crawlies
Year(s) Of Engagement Activity 2017
URL http://www.bbsrc.ac.uk/news/fundamental-bioscience/2017/171031-f-uk-creepiest-creepy-crawlies/
 
Description Big Bang Fair South East - RC 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Regional science festival/event - changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Biotech YES, Syngenta Jealott's Hill, 05 Oct 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Teams of postgraduate students from a number of universities and institutes attended talk as part of Biotech YES (Young Entrepreneurs' Scheme). Follow-up discussion influenced several aspects of their approach to entrepreneurship both within the competition and more generally
Year(s) Of Engagement Activity 2014,2015,2016,2017
 
Description Bluetongue and Wildlife (15 minute presentation on Epizootic Haemorhagic Disease Virus), (July/Pirbright, UK) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Policymakers reported greater interest in deer-associated diseases including EHDV and BTV
Year(s) Of Engagement Activity 2018
 
Description Bluetongue in wildlife workshop - presentation on "Bluetongue virus in deer (and other wildlife) - pathogenesis and immune responses" July 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact This workshop brought together policy makers, veterinary advisers and scientist to share information and discuss the role of wildlife for important Culicoides-borne viruses of ruminants. Gave 15 minutes presentation on "Bluetongue virus in deer (and other wildlife) - pathogenesis and immune responses"
Year(s) Of Engagement Activity 2018
 
Description CBD Open-ended online forum on synbio 06-10/2017 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact UN Convention on Biodiversity. Policy- discussion on synthetic biology: nominated participant in the Open Ended Online Forum on Synthetic biology as established in decision XII/24 of the Conference of the Parties to the Convention on Biological Diversity (COP) and extended in COP decision XIII/17 which ran from June to Oct 2017 (approx.)
Year(s) Of Engagement Activity 2017
URL http://bch.cbd.int/synbio/open-ended/discussion/
 
Description Cafe Scientifique, Bradfield School, West Berkshire: "How insects spread viruses" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Cafe Scientifique is a public forum for exploring the latest ideas in science and technology. Meetings take place in cafes, bars, restaurants and even theatres, but always outside a traditional academic context. I presented to an audience of the general public and answered questions.
Year(s) Of Engagement Activity 2017
 
Description Cafe Scientifique, Reading: "How insects spread viruses" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Cafe Scientifique is a public forum for exploring the latest ideas in science and technology. Meetings take place in cafes, bars, restaurants and even theatres, but always outside a traditional academic context. I presented to an audience of the general public and answered questions.
Year(s) Of Engagement Activity 2007,2017
 
Description Camberley Library Fun Palace 2018 - JM 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Caroline Seydel Genetic Literacy Project re GM mosquitoes/gene drive/Zika 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Provided background material and quotes for article on GM mosquitoes and control of Zika virus.
Year(s) Of Engagement Activity 2017
URL https://geneticliteracyproject.org/2018/01/29/waging-war-mosquito-split-gene-drive-hinder-spread-zik...
 
Description Chair of organising Committee for Wellcome Trust-Animal Genetics and Diseases 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This meeting brought together specialists working on the interface between genomics, genetic engineering and infectious disease with the aims of improving animal and human health and welfare.

Scientific sessions included:
Genetics of immune responses and disease resistance
Genetically engineered livestock (including genome editing)
Quantitative genetics and epigenetics applied to disease
Epidemiology and pathogen evolution
Bioinformatics, comparative and functional genomics
Precision medicine of animal companions
Year(s) Of Engagement Activity 2017
URL https://coursesandconferences.wellcomegenomecampus.org/events/item.aspx?e=635&dm_i=2SUU,HOGH,4R4AW1,...
 
Description Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Institute stand at the festival covering the Institute science in general, and transmission and gene editing to control disease, in particular.
Year(s) Of Engagement Activity 2018
 
Description Cheltenham Science Festival 2018 - JA 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Major science festival - changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Cheltenham Science Festival 2018 - JM 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Major science festival - changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Cheltenham Science Festival 2018 - JP 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Major national science festival - changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Cheltenham Science Festival 2018 - RC 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Major science festival - changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Cheltenham Science Festival 2018 - SV 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Display at major science festival: changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Cheltenham Science Festival 2018-DP 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Major national science festival - changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Discuss gene drives with NZ Parliamentary Commissioner 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Met NZ Parliamentary Commissioner to provide background information on, and discuss, gene drive systems. New Zealand is considering genetic and other control methods for invasive pests.
Year(s) Of Engagement Activity 2018
 
Description EMBO Conference: Molecular and population biology of mosquitoes and other disease vectors: vector and disease control 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on "Manipulation of the sex determination pathway in the African malaria mosquito Anopheles gambiae" given during the meeting held on 24 - 28 July 2017 in Kolymbari, Greece.
Year(s) Of Engagement Activity 2017
URL http://meetings.embo.org/event/17-vector-control
 
Description Encouraging women into science and engineering STEM. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact MH Visited Warwick School, Redhill to talk to secondary students about careers in STEM. A very positive outcome and well received.
Year(s) Of Engagement Activity 2018
 
Description European Society Vector Ecology (Invited Chair for two sessions and speaker for 15min talk); (October/Palermo, Sicily) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chaired two sessions, one on vector-borne diseases, one on scientific networks. Latter included a discussion with early career researchers. Main outcome was coordination between active networks including The Gnatwork.
Year(s) Of Engagement Activity 2018
URL http://www.sove.org/European%20SOVE%20folder/greecescientificprogram/palermo_Scientific_program_revi...
 
Description Ewen Callaway Nature 08/01/2018 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Provided expert background information for article in Nature regarding engineering species barriers, described by journalist as "very helpful" in followup email.
Year(s) Of Engagement Activity 2018
 
Description FAO/IAEA Coordinated Research Programme on methods of sex separation in mosquitoes; Research coordination meeting Bangkok 19-23 February 2018 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact FAO/IAEA Coordinated Research Programme on exploring genetic, molecular, mechanical, and behavioral methods of sex separation in mosquitoes; aimed at promoting specific areas of research, exchange of ideas and networking among the experts in the field.
Year(s) Of Engagement Activity 2013,2015,2016,2018
 
Description Facebook Live: Infectious Disease Portrayals in Pop Culture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Infectious diseases are a frequent topic in movies. The CDC has used zombies to talk about infectious disease and disaster preparedness, and infotainment has flamed fears of Ebola. I took part in a Facebook Live chat organised by the AAAS Public Engagement team about why infectious diseases are so often the topic of pop culture discussions; what movies, books, and other pop culture gets right and wrong about infectious disease; and how scientists can use pop culture as a jumping-off point for public engagement. The chat was broadcast live on the AAAS Facebook page.
Year(s) Of Engagement Activity 2017
URL https://www.aaas.org/event/facebook-live-infectious-disease-portrayals-pop-culture
 
Description Gene Drive Resarch Sponsors and Supporter's Forum meeting Montreal Sept 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Supporters
Results and Impact Forum met to discuss the state of the art and future considerations for gene drive research. Ongoing deliberations including specific follow-up meetings.
Year(s) Of Engagement Activity 2018
 
Description Holly Kernot, Veterinary Times, 13/06/2017 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Discussed potential of manipulating mosquito sex determination genes as tools for novel mosquito genetic control approaches.
Year(s) Of Engagement Activity 2017
URL https://www.vettimes.co.uk/news/study-to-be-transformational-in-mosquito-control-strategies/
 
Description Holt School Surrey. Bee meadow & A-level outreach Talk. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact I discussed the importance of pollinators for biodiversity and food security with the younger students. I also discussed careers in science with A-Level students. There was good interaction and many questions surrounding both topics.
Year(s) Of Engagement Activity 2018
 
Description IUCN Technical Subgroup on Synthetic Biology and Biodiversity Conservation (meeting 12-15 April and report) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Participated as member in Technical Subgroup on Synthetic Biology and Biodiversity Conservation of International Union for Conservation of Nature (IUCN). Meetings, online discussion and ultimately a report to Task Force and will ultimately go to IUCN General Assembly.
Year(s) Of Engagement Activity 2018,2019
 
Description InnovSur : Conference in IRD Montpellier on Insect Vector Surveillance 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Working group on standardisation of techniques for surveillance of insect vectors. Included break out group brainstorming and subsequent commentaries. Total audience approximately 110 people for main lectures.
Year(s) Of Engagement Activity 2018
URL https://www.alphavisa.com/isessah-innovsur/2018/
 
Description Innovate Guildford 17 March 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Talk and exhibit at Innovate Guildford - >100 for talk, probably >500 for exhibit. Both sparked questions and discussion afterwards.
Year(s) Of Engagement Activity 2018
 
Description Innovate Guildford 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Institute stand at the Innovate Guildford event, covering the work of the Institute in general and genetic modification through gene editing specifically.
Year(s) Of Engagement Activity 2018
URL https://www.guildford.gov.uk/IG18
 
Description Innovate Guildford 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Gave open talk at Innovate Guildford; 50-60 audience with wide age range, many questions and lively debate
Year(s) Of Engagement Activity 2018
 
Description Innovate Guildford 2018 - JM 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Regional science/innovation event - changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Innovate Guildford 2018 - SB 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Regional science festival - changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Innovate Guildford 2018 - SV 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Display at regional science/innovation festival - changes in public attitudes and stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Innovate Guildford Outreach (12th March) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact With amazing exhibits, activities, workshops, talks and competitions, it's FREE to attend. Explore the four zones: Engineering, One Health, Digital Media and Future Living, experience interactive performances, hear inspiring speakers (including leading gaming pioneer Peter Molyneux and animal health pioneer Professor Nick Bacon) and take in an amazing atmosphere. Theatre, music and comedy will feature through the day, with everything from how technology might have affected Shakespeare's plays to risky recycling and photographic secrets.
Year(s) Of Engagement Activity 2017
URL https://www.guildford.gov.uk/innovateguildford
 
Description Insect Festival 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Ran a stand on blood-sucking arthropods and their role in the transmission of disease at the Royal Entomological Society's Insect Festival. Talked to public, answered questions. Lots of enquiries about ticks, midges, mosquitoes and large biting flies (particularly horseflies).
Year(s) Of Engagement Activity 2017
URL https://www.yorkmuseumstrust.org.uk/whats-on/events/insect-festival-2017/
 
Description Invited Chair at European Congress of Entomology (Naples,July) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chaired session on vector-borne diseases at meeting and subsequent question sessions with 15 minute presentation on Culicoides biting midges.
Year(s) Of Engagement Activity 2018
URL http://www.ece2018.com/scientific-programme/day-1-monday-2-july/
 
Description Invited expert to the International gnatwork training workshop in Bangladesh 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact One of the invited disease experts to deliver an international training workshop in Bangladesh on the biology and vectorial roles of blackflies, sandflies and Culicoides biting midges. Initially this involved a presentation on "Of creatures big and very small - veterinary aspects of veterinary vector-borne pathogen research" at the start-up conference in Dhaka followed by a 4 day practical workshop at the BRAC learning centre (Mymensingh) where I was part of the training team on study design, data analysis and genetic identification of vector insects using molecular diagnostics.
Year(s) Of Engagement Activity 2018
URL https://www.gnatwork.ac.uk/bangladesh-18
 
Description Invited presentation at the Friedrich Loeffler Institute (January; Riems) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Formal presentation on biting midges and bluetongue to professional audience with question session and collaborative meetings
Year(s) Of Engagement Activity 2019
 
Description Invited seminar at UC Riverside 05/05/2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited seminar at University of California, Riverside
Year(s) Of Engagement Activity 2017
 
Description Invited seminar at the National Health Research Institutes, Taiwan. 27 Feb 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A presentation describing research in my group on mosquito developmental biology and its potential uses for mosquito control; attended by primarily by members of the National Mosquito-Borne Diseases Control Research Center.
Year(s) Of Engagement Activity 2018
 
Description Invited speaker British Society of Veterinary Pathology Annual Meeting 2018, Applied Ruminant Pathology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker on "Bluetongue virus and Schmallenberg virus - recognising the continued threat of Culicoides-borne viruses of ruminants" British Society of Veterinary Pathology Annual Meeting 2018, Applied Ruminant Pathology
School of Veterinary Medicine, University of Surrey, 29th of September 2018,
Year(s) Of Engagement Activity 2018
URL https://www.bsvp.org/event/applied-ruminant-pathology-disease-investigation-diagnosis-and-surveillan...
 
Description Invited speaker VECTOR-BORNE DISEASES (VBD) IN THE UK - BIENNIAL MEETING 2018 John Innes Centre Norwich 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker on "The Host-vector-pathogen Interface of Culicoides-borne Bluetongue Virus" at the VECTOR-BORNE DISEASES (VBD) IN THE UK - BIENNIAL MEETING 2018 John Innes Centre Norwich 4th-5th December 2018
Year(s) Of Engagement Activity 2018
 
Description Invited speaker at APHA surveillance meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker on insect surveillance at Animal and Plant Health Agency meeting with discussion around current studies.
Year(s) Of Engagement Activity 2018
 
Description Invited to attend and present at the RSPCA Lay members Forum, Royal Society London 10th of December 2018 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact Invited to attend to the RSPCA Lay members Forum, Royal Society London 10th of December 2018 and present on the ethical review process of animal research
Year(s) Of Engagement Activity 2018
URL https://science.rspca.org.uk/sciencegroup/researchanimals/ethicalreview/differentsystems/uk/events
 
Description Kingdown School Warminster Wiltshire talk to 6th form students about career in science. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact I presented my career path to the students to engage them on STEM careers. I had a good level of discussion and many questions.
Year(s) Of Engagement Activity 2018
 
Description Launch of first industry guidance on safe working with arthropods and GM insects 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Around 50 biosafety professionals and regulators including representatives from HSE attended the formal launch of the first industry guidance on working safely with arthropods and genetically modified insects on 21st April at Pirbright. This initiative originated with Sharon Webster, Chair of ISTR's Biosafety Steering Group, and was developed based on consultation with myself and members of my group with practical experience of working with arthropods in containment.
Year(s) Of Engagement Activity 2017
URL https://www.pirbright.ac.uk/news/2017/04/first-industry-guidance-safe-working-arthropods-and-gm-inse...
 
Description Lecture given to University of Surrey MSc Veterinary Microbiology students 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact A 2-hour teaching lecture given to 10 MSc Veterinary Microbiology students at the University of Surrey on 8th December (Lara Harrup)
Year(s) Of Engagement Activity 2017
 
Description Lecture of dynamics of vector-borne diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Lecture on the dynamics of vector-borne diseases as part of Part II Pathology: Dynamics of Infectious Diseases course at Univerity of Cambridge
Year(s) Of Engagement Activity 2008,2009,2010,2011,2012
 
Description Lecture on dynamics of infectious diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Lecture as part of MSc in Veterinary Microbiology at University of Surrey
Year(s) Of Engagement Activity 2012,2013,2014,2015,2016
 
Description MF PAG 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The Plant and Animal Genome XXIV Conference (PAG) is designed to provide a forum on recent developments and future plans for plant and animal genome projects. Consisting of technical presentations, poster sessions, exhibits and workshops, the conference is an excellent opportunity to exchange ideas and applications on this internationally important project.
Year(s) Of Engagement Activity 2014,2016
 
Description Nick Rufford, Sunday Time Mag, published 27/08/2017 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Provided information and quotes for Sunday TImes Magazine article on GM mosquitoes and Zika
Year(s) Of Engagement Activity 2017
URL https://www.thetimes.co.uk/article/how-genetically-engineered-mosquitoes-will-save-lives-kwc8nmwh5
 
Description Organiser of the Animal Genetics and Diseases conference 08 - 10 May 2019 Wellcome Genome Campus, UK. Highlighting recent advances in animal genetics and genomic technologies. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I am on the organising committee for this conference. The second conference in this series will highlight recent advances in animal genetics and genomic technologies. It will bring together specialists working on the interface of genomics, genetic engineering and infectious disease with the aims of improving animal and human health and welfare.

Novel genomic technologies, mathematical modelling and quantitative genetics approaches, applied to host animals, as well as their pathogens, have transformed the understanding of animal diseases, host-pathogen interactions and epidemiology and their effects on productivity of farmed animal species and food supply chains.

This year's conference will not only put the spotlight on the immune response of host animals and epidemiology but also cover the genetics and genomics of pathogens and the impact of animal-human relationships.

We encourage registrations from researchers, breeders and technical specialists interested in learning and disseminating the latest cutting-edge techniques and methodologies across model species, wildlife, farmed animals and companion animals.
Year(s) Of Engagement Activity 2019
URL https://coursesandconferences.wellcomegenomecampus.org/our-events/animal-genetics-diseases-2019/?dm_...
 
Description Oxford DTP students 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact High level overview of diseases studied [at Pirbright], and the importance of our work, provided to a group of over 30 Oxford DTP students, followed by a networking lunch (29th September 2017).
Year(s) Of Engagement Activity 2017
 
Description Pandemic Live (Cheltenham Science Festival) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Approximately 250 attendees at a 1 hour discussion around a simulated virus outbreak scenario (Speakers Fry; Carpenter; Beard; Hatchett). Followed by question and answer session.
Year(s) Of Engagement Activity 2018
URL https://www.cheltenhamfestivals.com/science/whats-on/2018/pandemic-live/
 
Description Participant in IDEAS arboviruses workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Participated in discussions and breakout groups, formed contacts. Planned future meetings on minimum reporting standards in insect infection studies (now funded and scheduled for 2018).
Year(s) Of Engagement Activity 2017
URL http://ideas.princeton.edu/workshop-for-2017/
 
Description Participation in a meeting regarding sex determination, Duesseldorf, Germany 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation entitled "Sex determination pathway in Anopheles gambiae as a target for mosquito control" during the Nothiger meeting on sex determination in insects, Duesseldorf, 11-13 March 2019.
Year(s) Of Engagement Activity 2019
 
Description Population Biology of Vector-Borne Diseases Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on "Population biology of Culicoides-borne viruses in Europe" at symposium held at University of Georgia Athens on 24 February 2018
Year(s) Of Engagement Activity 2018
 
Description Postdocteral scientist - oral presentation at the 12th Annual meeting of Epizone (joint with 11th International Congress for Veterinary Virology, ESVV 2018) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Postdoctoral scientists abstract submission was selected for oral presentation. Project results obtained at the time were presented to a highly interested and engaging audience of more than 250 scientists, veterinarians, students and policymakers.
Year(s) Of Engagement Activity 2018
URL https://www.epizone-eu.net/en/Home/News/show/Abstract-book-EPIZONEESVV-meeting-now-online-.htm
 
Description Presentation and sicussion with members of the CLA group visiting Pirbright Institute 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The CLA is the membership organisation for owners of land, property and businesses in rural England and Wales. The CLA came for a visit to the Pirbrigtht Institute and I presented on Bluetongue virus epidemiology, transmission and risk to the UK agriculture followed by a general discussion
Year(s) Of Engagement Activity 2017
 
Description Presentation at the EU BTV reference laboratory meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Presentation of BTV pathogenesis and effects of Culicoides saliva to representatives from all European reference laboratories plus some additional participants from the EU and industry
Year(s) Of Engagement Activity 2017
 
Description Princess Anne opening Jenner 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Princess Anne, entourage, local politicians and dignitaries visited to open new research building. I was one of small number asked to present/demonstrate/describe our research work, which is on genetic modification of mosquitoes to provide new tools with which to help control mosquito-borne viral diseases.
Year(s) Of Engagement Activity 2017
 
Description Public Health Entomology Group (LSHTM) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited lecture on 4th April 2017.
Year(s) Of Engagement Activity 2017
 
Description RSB Animal Science Group Sept 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Participated in RSB Animal Science special-interest group discussion on development of gene drives.
Year(s) Of Engagement Activity 2018
 
Description Reddit AMA (Ask Me Anything) on vector-borne diseases 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Took part in a Reddit Ask Me Anything (AMA) on vector-borne diseases. AMAs are a question-and-answer format activity where an individual expert or panel of experts answers questions from the public for a specified duration. We received a large number of questions and the parent post received 493 upvotes, indicating an absolute minimum of 493 participants (and very probably more), so I have given the estimated audience as 500+.
Year(s) Of Engagement Activity 2017
URL https://www.reddit.com/r/science/comments/6he8go/aaas_ama_hi_were_maria_elena_bottazzi_marcia/
 
Description Respond to SMC enquiry re gene drives in mice 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Responded to Science Media Centre request for expert comment on a scientific paper regarding gene drives in mice. Quoted in The Independent
Year(s) Of Engagement Activity 2019
URL https://www.independent.co.uk/news/science/gene-editing-dna-technology-mice-pests-drives-invasive-sp...
 
Description Respond to SMC request re Vosshall paper 08 Feb 2019 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Respond to SMC request re scientific paper describing behaviour-altering drugs in mosquitoes
Year(s) Of Engagement Activity 2019
 
Description Royal Institution Christmas Lectures Family Day - LA 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Six Pirbright staff/students ran an all-day exhibit on gene editing and mosquitoes at the Royal Institution About 270 participants visited our stand; wide range of comments, questions, discussion and feedback
Year(s) Of Engagement Activity 2019
 
Description Royal Institution Christmas Lectures Family Day - SB 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact About 270 participants visited our stand; wide range of comments, questions, discussion and feedback
Year(s) Of Engagement Activity 2019
 
Description Royal Society of Biology Biology week talk, Winchester, 10/10/2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Talk organized by Royal Society of Biology as part of Biology Week. This one in Winchester, audience was general public with strong representation of school-age. Questions and discussion during and after formal talk.
Year(s) Of Engagement Activity 2017
 
Description SMBE 2018 meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation entitled "Phylogenetically young genes and their function in Anopheles mosquitoes" given during the Society for Molecular Biology and Evolution 2018 meeting (8-12 July 2018) in Yokohama, Japan. Discussions held with potential collaborators on joined future research projects.
Year(s) Of Engagement Activity 2018
URL https://www.smbe2018.jp/
 
Description STEM Day - Speed interviews and Careers Day 2018 - BA 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description STEM Outreach Event (Farnborough, 9th November) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact See web link
Year(s) Of Engagement Activity 2016
 
Description Scheduled Twitter session with University of Nottingham students on professional skills for biosciences 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact Hour-long Twitter chat on Friday 12th May with biotechnology students, microbiology students, animal science students interested in animal diseases and animal welfare and behaviours and agriculture students interested in livestock.
Year(s) Of Engagement Activity 2017
URL https://twitter.com/search?q=%23biosciprofskills
 
Description School visit 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Gave a presentation to a group of students about research performed at the Pirbright Institute and discussed different aspects of scientists' work.
Year(s) Of Engagement Activity 2017
 
Description School visit (Farnborough) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Gave a presentation to a group of students about research performed at the Pirbright Institute and discussed various aspects of scientists' work.
Year(s) Of Engagement Activity 2018
 
Description Scientific Presentation: SOVE lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Society of Vector Ecology Presentation 'The Gnatwork'. 6th October 2017 over 150 attendance.
Year(s) Of Engagement Activity 2017
URL http://www.uibcongres.org/sove2017/
 
Description Site tour with Department of Trade and Industry 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Tour/site visit with Department of Trade and Industry (25 people attending)
Year(s) Of Engagement Activity 2017
 
Description Sutton College Lecture (Enjoy your retirement) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Talk to group on virus outbreaks (Enjoy your retirement) - 16 people & class coordinator. Included simulation of a virus outbreak.
Year(s) Of Engagement Activity 2019
 
Description TW Society for General Microbiology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Society for General Microbiology 2015 Meeting
Year(s) Of Engagement Activity 2015
 
Description Tillingbourne Bug Hunt 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Local entomology event for general public - changes in public attitudes and stimulating increased interest in insects/entomology and research
Year(s) Of Engagement Activity 2018
 
Description Tillingbourne Bug Hunt (Christopher Sanders) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Insect identification event with general public (primarily schools).
Year(s) Of Engagement Activity 2018
 
Description Tillingbourne Year 3 Science Day 2018 - EL 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Stimulating increased interest in research
Year(s) Of Engagement Activity 2018
 
Description Tillingbourne bug hunt. New Rd, Chilworth, Guildford GU4 8NB 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Stimulating increased interest in science and research. Good interest and engagement.
Year(s) Of Engagement Activity 2018
 
Description Tour of Philip Mellor Insectary (Country Land and Business Association) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact Tour of Philip Mellor Insectary with Country Land and Business Association (20 people)
Year(s) Of Engagement Activity 2017
 
Description UK vector meeting 2018 (Organising committee; Chair) (December; John Innes Centre, UK) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Chaired and helped organise meeting on UK Vector-borne Diseases as part of committee. Included reviewing talks and inviting speakers.
Year(s) Of Engagement Activity 2018
URL http://www.hpruezi.nihr.ac.uk/media/29013/master-draft-vbd-programme-with-titles-oct18_.pdf
 
Description UK-India bioinformatics workshop 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact On February 9 2018 Pirbright organised a "UK-India bioinformatics workshop" in order to foster ties between Indian and UK bioinformaticians working in the field of livestock and crop research. Paolo Ribeca gave a talk on "Bioinformatics and sequencing at Pirbright".
Year(s) Of Engagement Activity 2018
 
Description University of Surrey Vet School Open Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Institute stand at Surrey Vet School - introducing the institute to prospective vet students
Year(s) Of Engagement Activity 2018
 
Description Winston Churchill Careers Fair. Winston Churchill School, Hermitage Road, St Johns, Woking, Surrey, GU21 8TL 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact AS attended and presented at this event to stimulate increased interest in science and research.
Year(s) Of Engagement Activity 2018
 
Description Workshop 1: Minimum Information for Reporting Arthropod Infection Studies 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A workshop was held as part of the VectorBiTE RCN annual meeting at Asilomar in CA. Attendance was roughly 60 people, mostly users of data resulting from experimental arthropod infection studies or arthropod ecological datasets. AW gave a presentation describing the objectives of the grant and then we formed breakout groups to discuss potential factors to report and their importance for different categories of users. The feedback was used to review and update the draft standards document before the second workshop as ASTMH's Trop Med meeting in New Orleans in October.
Year(s) Of Engagement Activity 2018
 
Description Workshop 2: Minimum Information for Reporting Arthropod Infection Studies 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A workshop was organised in collaboration with members of the ASTMH's Advisory Committee on Arthropod-borne Viruses (ACAV) at the start of the 2018 Trop Med annual meeting and was advertised via social media and society and project mailing lists. Around 30 people attended, mostly from the US but with representation from Asia, Europe and South America, and a mixture of senior academics, junior faculty and students. AW gave a brief introduction to the objectives of the workshop and AW, assisted by LH (a postdoc at Pirbright), helped participants pilot the questionnaire before its formal launch. Feedback was positive and used to refine the questionnaire before it was launched in November. As a result of specific points raised in the feedback, the survey was translated into French and Spanish and these versions were launched simultaneously to support involvement by a broader audience.
Year(s) Of Engagement Activity 2018
 
Description Workshop 3: Minimum Information for Reporting Arthropod Infection Studies 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A workshop was organised during the biennial UK VBD meeting in Norwich to improve awareness of the survey and increase completion. A short presentation was given by LH, a postdoc at Pirbright who has been assisting with the development of the questionnaire and standards documentation (as AW is leaving Pirbright in December) and then breakout groups formed to discuss particular challenges and any suggested changes as well as pathways to increasing the chances of uptake of the resulting guidelines. The feedback was recorded and will influence the resulting report/manuscript.
Year(s) Of Engagement Activity 2018
 
Description email interview with journalist (Sukanya Charuchandra, The Wire) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Email interview for journalist for "The Wire" - an online technology-focused media outlet. Helped provide context and impact for the resulting piece. https://thewire.in/the-sciences/scientists-identify-protein-that-mosquitoes-need-to-lay-viable-eggs
Year(s) Of Engagement Activity 2019
URL https://thewire.in/the-sciences/scientists-identify-protein-that-mosquitoes-need-to-lay-viable-eggs
 
Description international workshop on "Self-Propagation of Artificial Genetic Elements: Gene Drives, Risks & Tipping Points Bremen 19-20 June 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Workshop considering regulatory, social and technical environment for gene drive systems in insects, primarily for German and other EU regulatory and political entities.
Year(s) Of Engagement Activity 2018