Genome and Epigenome

Lead Research Organisation: John Innes Centre
Department Name: Contracts Office

Abstract

This project aims to understand how genomes are regulated and give rise to phenotypes, and how genomes evolve in response to varied growing environments and adapt to duplication and hybridization. Key outcomes include deeper understanding of the mechanisms of heredity, including how genome regulation and genetic variation contribute to phenotypic variation, including multi-genic variation that underlies complex yield-related phenotypes. We will also identify new avenues for breeding using knowledge of how meiosis, recombination and polyploidy shape genomes. This will enable new ways of exploiting wild germplasm and improve understanding of the genomic and phenotypic consequences of new hybrid and polyploid formation. With respect to wheat, this project will meet key research needs identified by the “wheat strategy working group” for the Biotechnology and Biological Sciences Research Council (BBSRC). These include unlocking the potential of wheat genome resources by understanding regulation of its polyploid genome. The genomic foundations of this work, accurate long-range sequence assembly of multiple wheat lines, have already been established in collaborations with EI and Cold Spring Harbor Laboratory (CSHL). This work strengthens a variety of key research partnerships. Nationally these include the DFW National Wheat Programme, EI and the European Bioinformatics Institute (EBI). Internationally this supports work in the International Wheat Yield Partnership (IWYP) and CIMMYT. These outcomes map directly onto the BBSRC Strategic Research Priority Agriculture and Food Security, Research Councils UK (RCUK) priorities in Global Food Security, and the Government’s Agri-technology Strategy, because they will accelerate the discovery of useful new genetic variation for crop improvement and facilitate the rapid and precise integration of new germplasm and genetic variation into crop plants. This will establish new ways of working with researchers and plant breeders, and provide important new opportunities for academic and commercial innovation in crop improvement.

Publications

10 25 50
 
Description We have generated a number of key findings:

1.1 We have developed a new model of epigenetic memory, where transcription acts antagonistically to Polycomb-based silencing, which has enabled us to evaluate both trans and cis inputs to epigenetic regulation. A combination of chromatin biochemistry and computational analysis enabled us to show that epigenetic silencing at the Arabidopsis FLC locus involved distinct phases that were associated with different protein complexes and different timescales, a paradigm relevant for Polycomb silencing in all organisms. We have defined a new phase in the Polycomb mechanism instrumental in natural variation of silencing at Arabidopsis FLC, mediated by a combination of noncoding SNPs. We have demonstrated that liquid-liquid phase separation (LLPS) is an important mechanism in the antisense-mediated regulation of Arabidopsis FLC transcription. We identified a role for the FLL2 coiled coil protein to help promote LLPS of the RNA-binding protein FCA and found that 3' RNA processing components colocalize with FCA in these nuclear bodies in vivo. These bodies promote proximal polyadenylation of many transcripts in the Arabidopsis genome. We have uncovered the role of chromatin remodeling in temperature dependent tissue specification programme controlling fruit dehiscence. Working with a team at Peking University we have shown that the RNA modification m6A is enriched on the COOLAIR antisense transcript and functions to promote transcription termination. Working with a team at SLU, Uppsala, we have demonstrated that the quantitative transcription of FLC involves switching between opposing chromatin states that influence transcriptional initiation and elongation. We have established the co-transcriptional link between alternative processing of antisense transcripts at FLC and a change in chromatin environment, providing a new paradigm in chromatin-based gene regulation. We have also shown how FRIGIDA, the transcriptional activator of FLC, is sequestered into nuclear bodies early upon cold exposure.

The auxin response factor, ETTIN, mediates auxin response in a non-canonical fashion that is TIR1/AFB-independent. We have used biochemical and biophysical approaches to establish that ETTIN activity is regulated via direct interaction with the auxin hormone. ETTIN mediates its effect by recruiting components that modifies histone methylation/acetylation. In addition, we have uncovered that ETT interacts with ARF4 to establish a direct link between canonical (TIR1-dependent) and non-canonical (ETT-dependent) uncovered cross-talk between the non-canonical and canonical (TIR1/AFB-dependent) pathways.

In addition to the stated objectives we have investigated the molecular mechanisms of cold sensing in Arabidopsis. We established VIN3-luciferase screen to identify regulators of cold sensing and modelled short and long-term cold sensing mechanisms. We also demonstrated that the long-term cold sensor involves cold-induced accumulation of NTL8 (a direct regulator of VIN3) through a reduced dilution mechanism.

1.2 We have characterised the role of H2A.Z nucleosome dynamics in defense gene regulation and its response to temperature. We studied the role of SWR1 chromatin remodeling complex and H2A.Z nucleosomes in environmental responses using gene expression analyses and chromatin dynamics in the context of environmental responses. We have found that while H2A.Z nucleosomes in general repress gene expression of growth and developmental genes at lower ambient temperatures, they have been shown to be essential for inducible expression of key genes in response to microbial pathogens.

1.3 We have found that DNA methylation reprogramming occurs throughout the male germline in Arabidopsis, and revealed the RNA-directed DNA methylation pathway (RdDM), which targets transposons in soma, induces methylation of genes specifically in the germline, thereby regulating gene expression and meiosis. Our data further indicate that germline-specific methylation at genes is established by RdDM-associated siRNAs produced by the meiocyte nurse cells, also called tapetum. We discovered that linker histone H1 is gradually depleted during male gametogenesis, and this developmental depletion causes heterochromatin decondensation in vegetative progenitor cells and promotes pollen fertility. Additionally, we revealed the mechanism of TE activation in the vegetative cell via DEMETER-mediated DNA demethylation, and elucidated the complex interactions between DNA methylation and histone H1.

We have discovered that the DDM1/Lsh proteins facilitate epigenetic inheritance in plants and mammals by allowing DNA methyltransferases to access DNA wrapped in nucleosomes. We discovered that linker histone H1 and CG DNA methylation prevent the activity of euchromatic gene silencing pathways in plant heterochromatin, thereby enabling the maintenance of distinct functional chromatin domains. We demonstrated that DNA methylation prevents aberrant transcription within plant genes and also likely contributes to transcriptional homeostasis in animals. We have successfully developed simple bistable mathematical models for CpG DNA methylation dynamics. Using these models, we discovered that intermediate levels of CG DNA methylation can be stably inherited, indicating that epigenetic transmission of DNA methylation requires a balance of templated and untemplated methyltransferase activities.

In addition to the stated objectives, we have discovered that germline-specific methylation at genes is a conserved phenomenon among diverse land plants, including maize and the most basal lineage of extant land plants, Marchantia. Collaborating with a team at Cambridge University, we also discovered a novel mode of meiotic recombination control via a meiocyte-specific (meiocyte, the cell going through meiosis) subunit of the general RNA polymerase II transcription factor TFIID.

2.1 We have demonstrated that evolutionarily recent small RNAs can be acted upon by selection and contribute to the evolution of phenotypic diversity. Also, that selection and gene flow shape genomic islands that control phenotypic variation among species. We have published the Antirrhinum genome sequence. Through a genome-wide analysis we have shown that the only loci contributing to differentiation between two Antirrhinum subspecies map to flower colour loci. We have developed bioinformatic methods for identifying inverted repeats and their presence/absence in different species, and have mapped genes controlling species traits by F2 segregation. We have provided constructs to our Japanese collaborators to transform Torenia.

We performed a large-scale population genomic study to test the hypothesis that escape from extinction following the meiotic trauma of WGD was mediated by adaptive gene flow between Arabidopsis arenosa and its sister Arabidopsis lyrata. We found that A. lyrata underwent WGD more recently than A. arenosa, implicating specific pre-adapted alleles from A. arenosa rescued A. lyrata autotetraploids from early extinction. On the other hand, we found strong signals of gene flow from A. lyrata to A. arenosa specifically at other crucial meiotic crossover loci that display dramatic signatures of selective sweep in both species upon WGD. Taken together, our data suggest the hypothesis that bidirectional gene swap allowed for an escape from extinction of both nascent autopolyploids, where the merger and of these hybrids is greater than the sum of their parts. We tested the hypothesis that autopolyploidy would decrease levels of background selection and thus affect the fundamental forces governing selection. To this end we performed broad population sampling and genome resequencing, demographic, coalescent, and selective sweep analyses and found that the impacts of polyploidy on population genomic processes are subtle yet pervasive, such as reduced efficiency of purifying selection, differences in linked selection and rampant gene flow from diploids. Initial masking of deleterious mutations, faster rates of nucleotide substitution and interploidy introgression likely conspire to shape the evolutionary potential of polyploids.

2.2 We have generated genetic lines in Arabidopsis arenosa that can be used for functional analyses of evolutionarily important genes. We have begun characterizing several of these genes already by breeding alternate homozygotes in tetraploid A. arenosa carrying derived versus ancestral meiosis genes that might be involved in adaptation to polyploidy and/or climate. We have also generated and analysed 300 Arabidopsis arenosa individuals and analysed these in a biogeographic context that will form a framework for future studies. We have studied the co-evolution of two interacting meiosis genes, ASY1 and ASY3. These show clear synergies suggesting they are co-evolving rather than individually contributing quantitatively to derived phenotypes. The initial study was a detailed cytological analysis, but biochemical studies are in progress.

2.3 We have studied the evolution of "weediness" in a lineage of A. arenosa that has adapted to challenging ruderal habitats. This was coupled with the evolution of rapid cycling via the evolution of CONSTANS and FLC. We have investigated the genomic consequences of adaptation to challenging growing conditions, uncovering a striking case of fluctuating selection on a salt transporter allele that confers tolerance specifically to moderate levels of salt via structural genomic variation. We also investigated the genomic basis of parallel adaptation to challenging low nutrient, metal contaminated soils. In this study we found a near lack of convergence between species adapted to the same challenging sites, suggesting a lack of constraint on the evolutionary pathways adaptive change may follow.

2.4 The first stage of research in understanding mechanisms that influence gene expression in allopolyploid wheat has been completed. This used comparisons of gene expression, DNA methylation and chromatin accessibility between highly conserved chromosome arms of diploid Ae tauschii and hexaploid bread wheat. The dramatic patterns of reduced and differential gene expression seen in the hexaploid genome context were tightly correlated with reduced chromatin access, with DNA methylation playing a negligible role. We have generated a new set of wheat allopolyploids by crossing two Ae. tauschii lines with durum wheat. Sequencing data has been generated for the transcriptome and chromatin analyses, including ATAC for chromatin accessibility, ChIP for histone marks on active and inactive genes, and HiChIP for assessing DNA proximities of genes with different activities and chromatin compaction. We are analysing these data and testing hypotheses about chromosome crowding, physical interactions between homoeologous loci, and interactions along chromosomes.

RNAseq (leaves and developing grain) for 4 new synthetic wheat lines and their tetraploid and diploid parents have been generated. Preliminary analyses show the essentially immediate imposition of dominant and repressive patterns of gene expression, in which there is preferential expression of AA, BB or DD genome homoeologs. About 30% of 1:1:1 homoeologous triads (about 51,000 genes) show these radical changes in gene expression. In independent crosses that make new synthetics there appear to be consistent patterns, and there are also DD genotype dependent patterns. In developing grain RNAseq we see a DD genes are more prone to differential regulation. Underlying these changes are rapid large-scale changes in chromatin accessibility and histone modifications consistent with rapid large-scale transcriptional re-programming upon the addition of DD genomes to AABB genomes. Analysis of DNA methylation shows remarkably stable over patterns. We are currently establishing the extent of paramutation-type mechanisms on dominant and repressive patterns of expression. Currently we are generating HiC data to assess if homoeologous chromosomes and loci interact. This may help explain the common patterns of homoeolog regulation we observe.
Exploitation Route Understanding of the principles of Polycomb epigenetic silencing and non-coding RNA-mediated transcriptional regulation is vital for the gene regulatory field in all eukaryotic organisms, as well as the plant biotechnology field.

We have found that germline-specific genic methylation is conserved among land plants and is modulated by the environment such as heat. This opens an avenue to understand the regulation of plant germline development by siRNAs, and the environmentally sensitive male sterility, which is a highly desired trait in crops.

Our data on the ETTIN-mediated auxin signalling pathway suggest involvement in polarity transition during developmental processes throughout plant development. We have established that the pathway is conserved at least between Arabidopsis and Brassica. Although early days, it is therefore likely that our discoveries in this area will lead to increased fertility and hence seed production. A model-to-crop translation pipeline of this project could be facilitated by our interaction with breeders e.g. via the BRAVO SLoLa (BB/P003095/1). Scientifically, the characterisation of this non-canonical auxin pathway has the potential to lead us and colleagues in the auxin community in different directions regarding gene regulation including biochemical condensation/phase separation and auxin-dependent transcription factor complex formation.

Several of our other findings are applicable to crop improvement, but it is very early in the process to say how they may be taken forward at this point.
Sectors Agriculture, Food and Drink,Environment

 
Description Our research is providing insights into how plant traits are inherited and evolve through genome regulation. This in turn helps us to understand how we can use this information for breeding plants, including crops, which are better fitted to our changing environment and to some of the more extreme environments they may need to be able to cope with in the future. We have discussed our findings with various industrial and commercial stakeholders. Ongoing discussions with the plant breeding industry allow us to explore how these findings can be used on a practical level, for example recent discussions on the potential development of double haploid homozygous lines at JIC which would allow us to improve the way in which we provide breeders with germplasm. Discussions with industry have indicated that desirable traits from a broad range of JIC Brassica research would be easier to incorporate into industrial breeding programmes if we succeed in implementing double haploid technology. Our research into the interplay between genetic and epigenetic factors is crucial to improving understanding genome regulation and how traits are inherited and exploited in crops. Team member Prof Caroline Dean's Wolf Prize for Agriculture (2020), which rewards exceptional achievements in science, is an indication of how important the research taking place in this research programme is to crop development. We are ensuring that this knowledge is passed on to future plant breeders through our training efforts, for example through a lecture on hybrids and heterosis to the JIC and UEA MSc programme in Plant Genetics and Crop Improvement. From this training programme, 47% of students go on to work in the plant breeding and related industries, which in turn support our food chain in terms of both crop and animal-based foods, contributing 7% of Gross Value Added to the UK economy (£109 billion) according to an Intellectual Property Office Report, published in 2016. To widen the application and impact of this research into the biomedical area, translational talks have been given at the Netherlands Cancer Institute, Human Genome Centre in Edinburgh, the Ludwig Institute for Cancer Research, Oxford, and the Systems Biology of Human Disease 2017 conference in Heidelberg. Our research findings have been incorporated into educational and training programmes to both train future scientists and encourage children to consider a career in science through regional, national and international mechanisms including (Youth STEMM Award, JIC International Undergraduate Summer Schools and the Gatsby Summer School).
First Year Of Impact 2017
Sector Agriculture, Food and Drink,Education
Impact Types Cultural,Societal,Economic

 
Description Invited participant to discuss UK participation on the EMPHASIS initiative to coordinate phonemics platforms across Europe
Geographic Reach Europe 
Policy Influence Type Participation in a national consultation
 
Description BBSRC Responsive Mode
Amount £779,224 (GBP)
Funding ID BB/S009620/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 03/2019 
End 03/2022
 
Description BBSRC responsive mode
Amount £940,069 (GBP)
Funding ID BB/P020380/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2017 
End 09/2020
 
Description EMBO Young Investigator
Amount € 15,000 (EUR)
Organisation European Molecular Biology Organisation 
Sector Charity/Non Profit
Country Germany
Start 01/2019 
End 12/2022
 
Description European Research Council Starting Grant
Amount € 1,500,000 (EUR)
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 09/2018 
End 08/2023
 
Description Gatsby Grant to Exceptional Researchers
Amount £35,000 (GBP)
Organisation Gatsby Charitable Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2018 
End 04/2019
 
Description Biochemical analysis of auxin in complex with the auxin response factor ETTIN 
Organisation University of Leeds
Department School of Biology
Country United Kingdom 
Sector Academic/University 
PI Contribution Development of expression system to produce a domain of ETT recombinantly in E. coli.
Collaborator Contribution Production of ETT domain in E. coli followed by NMR on the 950MHz machine at Univ Leeds and analysis or results.
Impact None yet. Collaboration just started in Jan 2019.
Start Year 2019
 
Description Biochemical and structural characterisation of ETT-mediated auxin signalling 
Organisation University of Grenoble
Country France 
Sector Academic/University 
PI Contribution Development of tools for recombinant production of ETTIN protein.
Collaborator Contribution Development of tools for recombinant production of TPL protein and providing expertise in biochemical and structural characterisation of protein-protein-ligand interactions..
Impact None yet.
Start Year 2017
 
Description Christine Mezard 
Organisation French National Institute of Agricultural Research
Department INRA Versailles
Country France 
Sector Academic/University 
PI Contribution We are evaluating the effect of AXR1 on the DNA methylation in male meiocytes
Collaborator Contribution They identified the AXR1 gene, whose mutation affects recombination during meiosis and generally the DNA methylome in somatic tissues.
Impact Too early to say
Start Year 2019
 
Description Cold Spring Harbor Laboratory 
Organisation Cold Spring Harbor Laboratory (CSHL)
Country United States 
Sector Charity/Non Profit 
PI Contribution CSHL partnership provides access to their sequencing laboratory and expertise in sequencing small RNAs
Collaborator Contribution sequencing RNA and small RNA from new wheat hybrids
Impact RNAseq data sets for analyses
Start Year 2017
 
Description Collaboration of Martin Howard with Fred Chang on fission yeast development 
Organisation University of California, San Francisco
Country United States 
Sector Academic/University 
PI Contribution Mathematical modelling and image analysis of fission yeast cell size dynamics
Collaborator Contribution Experimental genetic and imaging approaches to fission yeast size control
Impact Multi-disciplinary: mathematical modelling together with genetics/imaging in fission yeast
 
Description Elsoms 
Organisation Elsoms Seeds
Country United Kingdom 
Sector Private 
PI Contribution We have collaborated with Elsoms Seeds company to extend our work into Brassica napus.
Collaborator Contribution Elsoms Seeds produced double haploid Brasscia napus lines for us.
Impact Too early to say
Start Year 2019
 
Description Meiosis-specific TFIID in promoting recombination 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution We found a TFIID component is meiocyte specifically expressed, and performed meiocyte extraction and RNA-seq with wildtype and mutants.
Collaborator Contribution Identification of the allele and recombination phenotyping
Impact Not yet
Start Year 2017
 
Description Receptor-Hormone interaction assay 
Organisation Institute of Science and Technology Austria
Country Austria 
Sector Academic/University 
PI Contribution We have identified a potential interaction between the ETTIN (ETT) auxin response factor and the hormone auxin.
Collaborator Contribution The laboratory of Jiri Friml used DARTS assay to show that ETTIN interacts specifically with auxin.
Impact We have submitted a manuscript to the journal eLife, which is curretnly under review.
Start Year 2019
 
Description Understanding the effect of N6A-methylation of mRNA in meristem size control 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution We performed in situ hybridisation on ECT genes and analysis of fruit shape in eat mutants.
Collaborator Contribution The laboratory of Professor Peter Brodersen have characterised a subclass of the ECT family in Arabidopsis both genetically and molecularly.
Impact A manuscript led by Prof Brodersen was submitted to the journal Development including our contribution.
Start Year 2017
 
Description Keynote Lecture on epigenetics at the Netherlands Cancer Institute (NKI). 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Dean gave the Keynote lecture at the Dutch Chromatin meeting at the Netherlands Cancer Institute (NKI) on the 2nd November 2018. Translational talks (outside the field of plant science) increase the impact and application of GEN Science. Her talk was entitled: 'Epigenetic switching and antisense transcription'.
Year(s) Of Engagement Activity 2018
 
Description 23rd IPGSA Conference (Paris) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact 23rd IPGSA Conference (Paris)
Year(s) Of Engagement Activity 2019
URL https://pages.wustl.edu/ipgsa
 
Description 8-week Undergraduate Summer School 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact During 8 weeks of the summer of 2018 15 undergraduates participated in the John Innes Centre International Summer School, which provides invaluable insight and experience of research to undergraduates about to enter their final year of studies. Each student spends 8 weeks in a lab at either the Sainsbury Laboratory, the Earlham Institute or the John Innes Centre, all located on the Norwich Research Park working on a project that they have selected. Enrico Coen is a key player in the organisation and running of the summer school. Other scientists in GEN were also involved in the training and speaking to the students during their stay.
Year(s) Of Engagement Activity 2018
URL https://www.jic.ac.uk/blog/2018-undergraduate-summer-school/
 
Description ASM poster 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact PhD student Billy Aldridge presented a poster on the JIC annual science meeting, which sparked lots of interest and discussion. He won the runner-up award, and an opportunity for presenting his research orally during the annual science meeting next year (2018)
Year(s) Of Engagement Activity 2017
 
Description Article STEMM Champion: Sam Fox 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Cambridge Norwich Tech Corridor article about Sam Fox (Coen Lab) as a STEMM Champion.
Year(s) Of Engagement Activity 2019
URL https://www.techcorridor.co.uk/articles/tech-corridor-women-in-steam-the-scientists/
 
Description Article for farming press 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Brief article written for BSPB Plant Breedig Matter magazine on hybrid breeding and farm saved seed. This will have reached a raming audience explaining variety production, the plant breeding process and breeding for important traits
Year(s) Of Engagement Activity 2019
URL http://www.bspb.co.uk/BSPB_Plant_Breeding_Matters_Spring_2018.pdf
 
Description BBC Norfolk TV Interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact As ISP funding was publicised, local news media ran stories on the impact this will have to science, the environment, industry and the region.
Year(s) Of Engagement Activity 2017
 
Description BBSRC Institute Meeting on Epigenetics 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Around 100 researchers working on diverse aspects of epigenetic systems from the BBSRC institutes met at the Babraham Institute. The goal of the meeting was to identify common themes and possible synergies, both between organisms and between institutes. Avenues for future cooperation, both scientifically and in terms of collective funding, were enthusiastically explored.
Year(s) Of Engagement Activity 2020
 
Description BBSRC epigenetics workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact BBSRC epigenetics workshop
Year(s) Of Engagement Activity 2018
 
Description Bluebell Primary School assembly - speaking about careers in science 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact On the 18th May Caroline Dean visited Blueberry Primary School and talked in assembly about careers in science.
Year(s) Of Engagement Activity 2018
 
Description Brassica Genomics lecture x 2, University of East Anglie MSc course 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Lesture provided on the MSc course on current Brassica genomics research. Students were engaged and asked many questions. good discussion.
Year(s) Of Engagement Activity 2020
 
Description Brassica genetics lecture x 2 hours for University of East Anglia Plant Breeding and Crop Genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Lecture of the UEA Plant breeding course on Brassica genetics, basic concepts through to current research. Students were engaged and asked questions thoughout and following lecture. Impact is training future scientists/plant breeders
Year(s) Of Engagement Activity 2019
 
Description Careers talk at local school 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact On the 8 Jun 2018 Hepworth J. Promoted women in STEMM and plant biology at Dover Grammar School for Girls, Years 10-12 (approximately 150 students).
Year(s) Of Engagement Activity 2018
 
Description Careers talk for PhD students 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Wager N. gave a talk at the ENVEast Doctoral Training Programme about doing a PhD, career choices, and her current role at the JIC.
Year(s) Of Engagement Activity 2017
 
Description Chelsea Flower Show 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact 157 000 attendees at the Chelsea Flower Show had the opportunity to Engage with our research at our Silver Award Winning Exhibition at the Chelsea flower show.
Year(s) Of Engagement Activity 2019
URL https://genetics.org.uk/news/centenary-garden-exhibit-at-chelsea-flower-show-2019/
 
Description Clover Seeds and CN seeds visit 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Visit to JIC from members of Clover and CN Seed to discuss current industry needs and work ongoing at JIC where there could be potential interaction.
Year(s) Of Engagement Activity 2018
 
Description Cold Spring Harbor Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact This was a large conference bringing together scientists working on RNA regulation including how RNA structure affects phase transitions
Year(s) Of Engagement Activity 2019
 
Description College du France Lecture as a part of the L'oreal Women in Science Award 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Caroline Dean gave the College du France lecture highlighting her groups research into flowering time and vernalization. The lecture led to questions and discussions.
Year(s) Of Engagement Activity 2018
 
Description Communication with Elsoms Seeds company 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact I and Rachel Wells from JIC visited Elsoms Seeds company to discuss our work, the need of plant breeders, and potential future collaborations. As a result, we developed a collaboration working on Brassica napus, and are now evaluating the possibility of setting up transgenic work in Elsoms.
Year(s) Of Engagement Activity 2019
 
Description Conflict of interests: How do plants sense and integrate environmental signals. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited speaker at: Thermomorphogenesis 2016, (25 - 27 August 2016), Halle, Germany.
Year(s) Of Engagement Activity 2016
 
Description Conflict of interests: How do plants sense and integrate environmental signals? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited talk at BOKU, University of Natural Resources and Life Sciences, Vienna, Austria
April 2016
Year(s) Of Engagement Activity 2016
 
Description Discussion (YouTube video) with GARNet about 'Auxin-Induced Modulation of ETTIN Activity Orchestrates Gene Expression in Arabidopsis' publication 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact On the 31st of Auguts 2018 Prof Lars Ostergaard discussed his groups recent paper published in The Plant Cell entitled: Auxin-Induced Modulation of ETTIN Activity Orchestrates Gene Expression in Arabidopsis' with GARNet . Links shown below the video to guide the listener to more information about the research. The video has had 61 views (28.01.19)
Year(s) Of Engagement Activity 2018
URL https://www.youtube.com/watch?v=c2gI5SJkO0A&feature=youtu.be
 
Description Distinguished lecture at Penn State 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Distinguished lecture at Penn State
Year(s) Of Engagement Activity 2018
 
Description EMBL Chromatin & Epigenetics Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact The PI ( C Dean) attended this international symposium and met with other researchers undertaking analysis of protein oligomers and their importance in chromatin biology.
Year(s) Of Engagement Activity 2019
 
Description Elsoms Veg open day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Stand at the Elsoms Vegetable open day displaying the current work of JIC. Discussed many current projects with the industry members that visited the open day and trials
Year(s) Of Engagement Activity 2018
 
Description Elsoms seeds visit 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Visit by Elsoms seeds to discuss Speed breeding and speed cloning of disease resistance genes . Good discussions had.
Year(s) Of Engagement Activity 2018
 
Description Elsoms seeds visit 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Visit regarding Brassica research at JIC. Good discussion had
Year(s) Of Engagement Activity 2018
 
Description GARNet 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation at the GARNet 2018 conference
Year(s) Of Engagement Activity 2018
 
Description Gatsby Summer School plenary lecture entitled: 'Sensing and remembering winter'. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Dean C. gave the Gatsby Summer School plenary lecture entitled: 'Sensing and remembering winter'. This lecture sparked a lot of questions and further discussion.
Year(s) Of Engagement Activity 2017
 
Description Genes in the Environment newsletter issue 1 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Study participants or study members
Results and Impact A newsletter was developed to communicate the science taking place in the GEN ISP. The newsletter will be produced every 4 months. Issue one highlighted recent publications between Sept and Dec 2017 in the ISP as well as describing CRISPR/Cas9.
Year(s) Of Engagement Activity 2017
 
Description Gordon Conference 'Epigenetics' 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact This internationally recognized conference brings together epigenetics researchers from many organisms. This enabled high level discussions and important experimental planning.
Year(s) Of Engagement Activity 2019
 
Description Haldane Lecture: how genes & environment drive new evolutionary paths. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Prof Enrico Coen won the JBS Haldane Lecture for 2017. Enrico spoke about how genes and the environment drive new evolutionary paths.
The lecture itself attracted an audience of a few hundred people. In addition, the lecture was filmed and released on YouTube with over 22,000 views internationally.
It also raised awareness of Enrico Coen's podcasts:
1. Podcast with Enrico Coen - Defining DNA, and what is a gene?
2. Podcast with Enrico Coen - The snapdragon's tale
Year(s) Of Engagement Activity 2017
 
Description Heritage day talk on thermogenesis in plants 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact I gave a talk for the general public as part of the John Innes Centre's activities for Heritage Day. The talk was well received with numerous respondents to a survey commenting they had learned a lot and that it had opened their eyes to plant diversity and plant biology. This activity also focused on images from our rare books collection which the public were also invited to take a closer look at.
Year(s) Of Engagement Activity 2017
 
Description Hosted year10 student for a lab visit day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact We hosted students for year 10 science camp activities at JIC, which included their participation in lab activities as well as career discussions.
Year(s) Of Engagement Activity 2016,2017
 
Description Hybrids and Heterosis, 2 hours lecturing for University of East Anglia, Plant breeding and crop genetics MSc 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Letcures given on hybrids and heterosis to the UEA MSc students. Students were engaged and asked question during and following the lecture.
Year(s) Of Engagement Activity 2019
 
Description Inspiring Females Day - 3 inspiring GEN women 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact More than 250 girls from schools and Sixth Forms across Norfolk and beyond enjoyed a unique insight into science, technology and engineering (STEM) careers at a new event organised by Norwich High School.

Inspiring Females: STEM took place in the John Innes Centre at Norwich Research Park on Wednesday 2nd May. In attendance were girls from Sheringham, Wymondham, Long Stratton, Reepham, City of Norwich School, Sir Isaac Newton Sixth Form and Ormiston Victory Academy, as well as fellow GDST schools, Northampton High School and Sydenham High School.

During the day the students had the opportunity to meet 19 inspiring women all currently working in STEM industries, and enjoyed an opportunity to network with their mentors, and explore key issues in science, art and diversity. Three of these women were Dr Judith Irwin, Dr Cecilia Lovkvist and PhD student Jade Doughty in the GEN ISP.
Year(s) Of Engagement Activity 2018
URL http://www.inspiringfemales.org.uk/if-stem.html
 
Description Inspiring Females Day - panel member 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Caroline Dean was a panel member for the Inspiring Females day held at the JIC. She spoke about what it was like working as a plant scientist and her route through education to get to where she is now. She answered questions from the school students.
Year(s) Of Engagement Activity 2018
URL http://www.inspiringfemales.org.uk/if-stem.html
 
Description International Undergraduate Summer School 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact The International summer school provides 15 students with 8 weeks of training, invaluable insight and experience of research to undergraduates about to enter their final year of studies. Each student spends 8 weeks in a lab at either the Sainsbury Laboratory, the Earlham Institute or the John Innes Centre, all located on the Norwich Research Park working on a project that they have selected.
Year(s) Of Engagement Activity 2017
 
Description Interview article in school science magazine 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Sam Fox was interviewed for an article in a school magazine on the 7th March 2018. The interview was about her job as a plant scientist and the route educationally she took to get into that role.
Year(s) Of Engagement Activity 2018
 
Description Interview with eastern daily press 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact As ISP funding was publicised, local news media ran stories on the impact this will have to science, the environment, industry and the region.
Year(s) Of Engagement Activity 2017
 
Description Invited Talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited talk at VIB Ghent, Belgium. Talking about the research findings of the project.
Year(s) Of Engagement Activity 2016
 
Description Invited speaker at Peking University, Beijing, China 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Caroline Dean was invited to speak at Peking University, Beijing, China, on the 1st June. Her seminar was entitled: 'Epigenetic switching and antisense transcription'.
Year(s) Of Engagement Activity 2018
 
Description Invited speaker at Sustech Shenzhei, China. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Caroline Dean was invited to speak at Sustech Shenzhei, China on the 28th May. Her seminar was entitled: 'Epigenetic switching and antisense transcription'.
Year(s) Of Engagement Activity 2018
 
Description Invited speaker at Wellcome Trust Plant 'Genomes in a Changing Environment' meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Caroline Dean gave the keynote lecture on the 24th October 2018 at the Wellcome Trust Hixton Hall Plant Genomes in a Changing Environment meeting. Her talk was entitled: 'Adapting to different winters'.
Year(s) Of Engagement Activity 2018
 
Description JIC Science Innovation Showcase 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact JIC scientists presenting their science to invited industry/companies
Year(s) Of Engagement Activity 2018
 
Description MSc lecture given at UEA on Flowering and Vernalization 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Caroline Dean gave an MSc lecture on Flowering and Vernalization leading to many questions and further discussion with the students.
Year(s) Of Engagement Activity 2018
 
Description MSc lecture x 2 - Brassica genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Two lectures on Brassica genetics given for the University of East Anglia Plant Breeding MSc course. Lectures contained information on past and current work at JIC and provoked questions and discussion.
Year(s) Of Engagement Activity 2018
 
Description MSc lecture x 2 - Brassica genomics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Two lectures on Brassica genomics presented for the University of East Anglia Plant Breeding MSc course. Lectures for the teachig part of the students gaining this qualification. Lecture provoked questions and discussion from the students in this area. Ongoing work within Brassica genomics at the institute was included.
Year(s) Of Engagement Activity 2019
 
Description MSc lecture x 2 - Hybrids and heterosis 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Two lectures given on Hybrids and Heterosis for the University of East Anglia Plant Breeding MSc course. Details of past and current work at JIC included. Lecture stimulated good discussion and questions.
Year(s) Of Engagement Activity 2018
 
Description Mardlers dinner discussions 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact A group of local landowners/farmers (the Mardlers) were invited to JIC for discussions on current research. The Mardlers regularly meet in the local area with a JIC representative being in attendance at every meeting. As an alternative this event was held onsite at JIC. Discussions were held about current research at JIC and opinions heard from both the science, farming and economic areas. Both scientist and other attendees were educated about opinions and practices.
Year(s) Of Engagement Activity 2018
 
Description McClintock Lecture Cold Spring Harbor Laboratory 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Caroline Dean gave the Barbara McClintock Lecture at Cold Spring Harbor Laboratory NY on chromatin regulation and evolutionary adaptation. The talk stimulated discussion and questions.
Year(s) Of Engagement Activity 2018
URL http://cshlwise.org/institutional-events/mcclintock-lectures/
 
Description Noel Keen Special lecture at UC Riverside. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Prof Caroline Dean C gave the Noel Keen Special lecture at UC Riverside. Her talk was entitled: 'Sensing and remembering winter' discussing epigenetic memory, vernalization and temperature sensing in the field. The lecture lead to questions and further discussion.
Year(s) Of Engagement Activity 2017
 
Description Norwich Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Engagement activities with Norwich Science Festival on how genetics influences how plants grow and plant form
Year(s) Of Engagement Activity 2019
 
Description Participation in a 'Lives in Science' workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Karen Lee participated in a 'Lives in Science' workshop in a local school. During the workshop she spoke to the students about her career as a plant scientist and encouraged them to participate in interactive activities.
Year(s) Of Engagement Activity 2018
 
Description Perception and integration of environmental signals in plants 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited talk at: Arabidopsis 2016: Emerging Challenges in Plant Biology, Mohali, India
March 2016
Year(s) Of Engagement Activity 2016
 
Description Pint of Science talk to general public 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact "Watch out, it's a trap! Find out how plants evolve carnivorous structures spoiler alert - it's actually a modified leaf. " Chris Whitewoods gave a talk to the genral public on his research in the Coen Lab on the 14th May 2018.
Year(s) Of Engagement Activity 2018
 
Description Pint of Science talk: 'Jumping Genes! How The Environment Influences Our Genomes' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Dr Rebecca Mosher gave a talk entitled 'Jumping Genes! How The Environment Influences Our Genomes' as a part of Pint of Science in May 2018.
"Did you feel that? I think one of your genes just jumped! Dr. Rebecca Mosher studies those jumping genes and how our cells try to keep them still. Although jumping genes can be dangerous because they cause mutations, sometimes a lucky jump can create something new and useful."
Year(s) Of Engagement Activity 2018
URL https://pintofscience.co.uk/event/evolving-diversity-the-mechanisms-behind-evolution
 
Description Plant Genomics Conference (Nanchang, China) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Plant Genomics Conference (Nanchang, China)
Year(s) Of Engagement Activity 2019
 
Description Presentation at University of Lausanne 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Presentation at University of Lausanne
Year(s) Of Engagement Activity 2019
 
Description Presentation at the "Auxin and Cytokinin in Plant Development" conference in Prague 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact As part of the 'Auxin and Cytokinin in Plant Development' conference in Prague I was an invited speaker and gave a presentation on a novel auxin signalling pathway.
Year(s) Of Engagement Activity 2018
URL https://www.acpd2018.org
 
Description Press Release: Temperature resilient crops now an "achievable dream" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact A press release was completed on the story and released to the John Innes Centre website with a link to collaborators and the paper. The story was also then promoted via the social media platform including Instagram, Twitter and Facebook. To promote the story further distribution platforms including 'Eurekaalert' (for a science specific audience) and 'Vuelio' (for a more general audience) were used. Own contacts were also followed up including local news reporters to ensure the paper and story was well publicised. The story was covered in the following articles:
https://www.jic.ac.uk/press-release/temperature-resilient-crops-now-an-achievable-dream/

https://www.dailymail.co.uk/wires/pa/article-5382349/Gene-editing-hope-pod-shatter-crops.html

http://www.syngenta.ca/News/market-news/new-research-addresses-%E2%80%98pod-shatter%E2%80%99

https://www.svt.se/nyheter/vetenskap/varmare-klimat-inget-problem-for-grodor-i-framtiden
Year(s) Of Engagement Activity 2018
URL https://www.jic.ac.uk/press-release/temperature-resilient-crops-now-an-achievable-dream/
 
Description Press release "Distinguished role model for women in science receives global award" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact A press release was completed on the story and released to the John Innes Centre website with a link to collaborators and the paper. The story was also then promoted via the social media platform including Instagram, Twitter and Facebook. To promote the story further distribution platforms including 'Eurekaalert' (for a science specific audience) and 'Vuelio' (for a more general audience) were used. Own contacts were also followed up including local news reporters to ensure the paper and story was well publicised.
Year(s) Of Engagement Activity 2017
URL https://www.jic.ac.uk/news/distinguished-role-model-for-women-in-science-receives-global-award/
 
Description Press release "How Capsella followed its lonely heart" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact A press release was completed on the story and released to the John Innes Centre website with a link to collaborators and the paper. The story was also then promoted via the social media platform including Instagram, Twitter and Facebook. To promote the story further distribution platforms including 'Eurekaalert' (for a science specific audience) and 'Vuelio' (for a more general audience) were used. Own contacts were also followed up including local news reporters to ensure the paper and story was well publicised.
Year(s) Of Engagement Activity 2019
URL https://www.jic.ac.uk/press-release/how-capsella-followed-its-lonely-heart/
 
Description Press release: "Absence of warm temperature spikes revealed as driver for vernalisation" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact A press release was completed on the story and released to the John Innes Centre website with a link to collaborators and the paper. The story was also then promoted via the social media platform including Instagram, Twitter and Facebook. To promote the story further distribution platforms including 'Eurekaalert' (for a science specific audience) and 'Vuelio' (for a more general audience) were used. Own contacts were also followed up including local news reporters to ensure the paper and story was well publicised.
Year(s) Of Engagement Activity 2018
URL https://www.jic.ac.uk/press-release/absence-of-warm-temperature-spikes-revealed-as-driver-for-vernal...
 
Description Press release: "Breakthrough study reveals new insight into "immortal" plant cells" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact A press release was completed on the story and released to the John Innes Centre website with a link to collaborators and the paper. The story was also then promoted via the social media platform including Instagram, Twitter and Facebook. To promote the story further distribution platforms including 'Eurekaalert' (for a science specific audience) and 'Vuelio' (for a more general audience) were used. Own contacts were also followed up including local news reporters to ensure the paper and story was well publicised.
Year(s) Of Engagement Activity 2017
URL https://www.jic.ac.uk/press-release/breakthrough-study-reveals-new-insight-into-immortal-plant-cells...
 
Description Press release: "How Snapdragons keep their colour: signposting trick reveals evolutionary mechanism" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact A press release was completed on the story and released to the John Innes Centre website with a link to collaborators and the paper. The story was also then promoted via the social media platform including Instagram, Twitter and Facebook. To promote the story further distribution platforms including 'Eurekaalert' (for a science specific audience) and 'Vuelio' (for a more general audience) were used. Own contacts were also followed up including local news reporters to ensure the paper and story was well publicised.
Year(s) Of Engagement Activity 2017
URL https://www.jic.ac.uk/news/how-snapdragons-keep-their-colour-signposting-trick-reveals-evolutionary-...
 
Description Press release: "How Snapdragons keep their colour: signposting trick reveals evolutionary mechanism" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact A press release was completed on the story and released to the John Innes Centre website with a link to collaborators and the paper. The story was also then promoted via the social media platform including Instagram, Twitter and Facebook. To promote the story further distribution platforms including 'Eurekaalert' (for a science specific audience) and 'Vuelio' (for a more general audience) were used. Own contacts were also followed up including local news reporters to ensure the paper and story was well publicised. The press release led to the following articles:

https://www.nytimes.com/2017/11/17/science/snapdragons-colors-genes.html

https://www.edp24.co.uk/news/environment/norwich-scientists-discovery-of-genetic-gymnastics-in-snapdragons-brings-new-insight-into-evolution-1-5294260

https://www.atlasobscura.com/articles/snapdragons-spanish-pyrenees

https://www.sciencedaily.com/releases/2017/11/171116142146.htm
Year(s) Of Engagement Activity 2017
URL https://www.jic.ac.uk/news/how-snapdragons-keep-their-colour-signposting-trick-reveals-evolutionary-...
 
Description Press release: "Leap forward in understanding plant organ growth" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact A press release was completed on the story and released to the John Innes Centre website with a link to collaborators and the paper. The story was also then promoted via the social media platform including Instagram, Twitter and Facebook. To promote the story further distribution platforms including 'Eurekaalert' (for a science specific audience) and 'Vuelio' (for a more general audience) were used. Own contacts were also followed up including local news reporters to ensure the paper and story was well publicised.
Year(s) Of Engagement Activity 2018
URL https://www.jic.ac.uk/press-release/new-model-is-a-leap-forward-in-understanding-plant-organ-growth/
 
Description Press release: "Leaves possess a molecular compass" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact A press release was completed on the story and released to the John Innes Centre website with a link to collaborators and the paper. The story was also then promoted via the social media platform including Instagram, Twitter and Facebook. To promote the story further distribution platforms including 'Eurekaalert' (for a science specific audience) and 'Vuelio' (for a more general audience) were used. Own contacts were also followed up including local news reporters to ensure the paper and story was well publicised.
Year(s) Of Engagement Activity 2018
URL https://www.jic.ac.uk/news/leaves-possess-a-molecular-compass/
 
Description Press release: "New angle on how cells use geometry to control their size" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact A press release was completed on the story and released to the John Innes Centre website with a link to collaborators and the paper. The story was also then promoted via the social media platform including Instagram, Twitter and Facebook. To promote the story further distribution platforms including 'Eurekaalert' (for a science specific audience) and 'Vuelio' (for a more general audience) were used. Own contacts were also followed up including local news reporters to ensure the paper and story was well publicised.
Year(s) Of Engagement Activity 2019
URL https://www.jic.ac.uk/news/new-angle-on-how-cells-use-geometry-to-control-their-size/
 
Description Press release: "Plants have a plan for all seasons" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact A press release was completed on the story and released to the John Innes Centre website with a link to collaborators and the paper. The story was also then promoted via the social media platform including Instagram, Twitter and Facebook. To promote the story further distribution platforms including 'Eurekaalert' (for a science specific audience) and 'Vuelio' (for a more general audience) were used. Own contacts were also followed up including local news reporters to ensure the paper and story was well publicised.
Year(s) Of Engagement Activity 2018
URL https://www.jic.ac.uk/news/plants-have-a-plan-for-all-seasons/
 
Description Press release: "Snapdragon enters the genomic age" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact A press release was completed on the story and released to the John Innes Centre website with a link to collaborators and the paper. The story was also then promoted via the social media platform including Instagram, Twitter and Facebook. To promote the story further distribution platforms including 'Eurekaalert' (for a science specific audience) and 'Vuelio' (for a more general audience) were used. Own contacts were also followed up including local news reporters to ensure the paper and story was well publicised.
Year(s) Of Engagement Activity 2019
URL https://www.jic.ac.uk/press-release/snapdragon-enters-the-genomic-age/
 
Description Press release: "Surprise findings turn up the temperature on the study of vernalization" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact A press release was completed on the story and released to the John Innes Centre website with a link to collaborators and the paper. The story was also then promoted via the social media platform including Instagram, Twitter and Facebook. To promote the story further distribution platforms including 'Eurekaalert' (for a science specific audience) and 'Vuelio' (for a more general audience) were used. Own contacts were also followed up including local news reporters to ensure the paper and story was well publicised. The press release led to the production of 17 stories (16 online and 1 in print) following the publication of her paper.
• Ad value is the estimated cost of how much your coverage adds up if you took out an advert of equivalent prominence in that publication. This is: £1,936.74
• Monthly visits is for 16 online stories is worth = £13,537,978
• Circulation in the EDP for the one printed story = 40,713
• Laura was also interviewed by BBC Radio 4 Farming Today. No stats for this as story not aired yet.
Year(s) Of Engagement Activity 2019
URL https://www.jic.ac.uk/press-release/surprise-findings-turn-up-the-temperature-on-the-study-of-vernal...
 
Description Prime Agriculture LLP visit 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Visit by Prime agriculture to JIC to discuss ongoing work which may be of interest to crop consultants.
Year(s) Of Engagement Activity 2018
 
Description Public Lecture 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact I presented a lecture on plant research in my group at a Science, Chemistry and Innovation event in London on 28 Nov 2018. The audience was mixed, comprising students, the general public and industrialists
Year(s) Of Engagement Activity 2018
 
Description Putting it together: How do plants sense and integrate seasonal signals? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited talk at: Institut de Biologie de l'École Normale Supérieure (IBENS), Paris, France. This has led to the establishment of a collaboration involving scientists from France and Spain.
Year(s) Of Engagement Activity 2017
 
Description Radio 4 Life Scientific 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Caroline Dean participated in Radio 4's Life Scientific programme on the 8th May explaining the genetics of vernalisation to Jim Al-Khalili.
Year(s) Of Engagement Activity 2018
URL https://www.bbc.co.uk/programmes/b0b2jdxj
 
Description Research presentation at the EpiPlant conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Research presentation at the EpiPlant conference
Year(s) Of Engagement Activity 2019
 
Description Research presentation at the Ludwig institute for cancer research in Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Research presentation at the Ludwig institute for cancer research in Oxford
Year(s) Of Engagement Activity 2018
 
Description Research presentation at the Society for Experimental Biology annual conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Research presentation at the Society for Experimental Biology annual conference
Year(s) Of Engagement Activity 2018
 
Description Science Cafe Public talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Enrico Coen and Scott Boden gave a joint Science Cafe talk entitled 'Cereals and Snapdragons' to the general public in Oct 2018 as a part of the Norwich Science Festival.
Year(s) Of Engagement Activity 2018
 
Description Science Innovation Showcase 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact An event showcasing John Innes Centre science to industry, aiming to develop and promote new relationships between scientists and industry, breaking down any barriers and enabling productive collaborations.
Year(s) Of Engagement Activity 2018
URL https://www.jic.ac.uk/news-and-events/whats-on/science-innovation-showcase/
 
Description Scientist question time at a local school 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Rebecca Horn took part in 'scientist question time' at a local primary school answering questions about what a scientists do in their jobs.
Year(s) Of Engagement Activity 2018
 
Description Seminar given at University of Rennes entitled: 'Epigenetic switching and antisense transcription'. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact On the 14th May 2018 Caroline Dean gave a seminar at the University of Rennes entitled: 'Epigenetic switching and antisense transcription'.
Year(s) Of Engagement Activity 2018
 
Description Seventh Symposium on Plant Molecular Genetics (Sao Paolo, Brazil) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact The Brazilian Plant Genetics Scientific Community is hosting its Seventh Symposium on Plant Molecular Genetics, which will be held in Campos do Jordão, São Paulo, Brazil, from April 29 to May 3, 2019.

This is a joint effort between the Brazilian Genetics Society and the plant genetics scientific community to reinforce the need of Brazil to motivate the establishment of a strong research foundation in plant biology, given the importance of agriculture for the Brazilian economy.
Year(s) Of Engagement Activity 2019
URL https://www.sbg.org.br/en/events/vii-simposio-brasileiro-de-genetica-molecular-de-plantas/welcome
 
Description Skype interview with MSc student from Central St Martins University 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Discussions and advice on carnivorous plants, our research and scientific thinking for creation of an installation exploring plants in the environment.
Year(s) Of Engagement Activity 2019
 
Description Smithsonian magazine coverage of modelling work on how plants make leaves 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Coverage of our Science publication on understanding how leaf shape evolved through the study of carnivorous plants.
Year(s) Of Engagement Activity 2020
URL https://www.smithsonianmag.com/science-nature/deciphering-how-plant-genes-drive-weird-wonderful-dive...
 
Description Soapbox Science Norwich Science Festival: how plants shape their leaves 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact On the 27th October 2018 Beccy Horn in the Coen Lab stood on a raised platform in Norwich City Centre and spoke to the genral public about their research that understands how the different shapes of leaves are formed.
Year(s) Of Engagement Activity 2018
 
Description Soapbox Science: Norwich Science Festival 2018 public engagement 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Caroline Dean stood on a raised platform in Norwich City Centre on 27th October 2018 and chatted to the general public about vernalization and epigenetics as a part of the Soapbox Science session of Norwich Science Festival.
Year(s) Of Engagement Activity 2018
 
Description Talk at JIC Science for Innovation Showcase 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact The John Innes Centre invited representatives from industry to a workshop highlighting fundamental research going on at JIC that included open discussion and exchange with industry. I gave a talk at this symposium and was part of a discussion panel.
Year(s) Of Engagement Activity 2018
 
Description Talk entitled: 'How plants sense and remember winter' at the Max Planck Directors invitation only meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dean C. gave a talk entitled: 'How plants sense and remember winter' at the Max Planck Directors invitation only meeting, Harnack House, Berlin. The presentation triggered further questions and discussion.
Year(s) Of Engagement Activity 2017
 
Description Talk on epigenetic regulation at the Systems Biology of Human Disease conference in Heidelberg 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Martin Howard gave a talk on epigenetic regulation at the Systems Biology of Human Disease conference in Heidelberg triggering further discussion and questions. We hope that by giving talks at translational meetings and conferences the application and impact of GEN research can be increased.
Year(s) Of Engagement Activity 2017
 
Description Ted Talk: 'Sensing and remembering winter' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Caroline Dean gave a Ted Talk: 'Sensing and remembering winter' as a part of the L'oreal Women in Science Award. There were many questions and discussions after the talk triggered by the presentation.
Year(s) Of Engagement Activity 2018
 
Description The Cut: Science Cafe 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Invited talk at a local science cafe followed by panel debate and discussion session. Talk on Building Brilliant Brassicas ranged from researching current targets for crop improvement to genome editing. Good discussion, feedback and debate was received.
Year(s) Of Engagement Activity 2018
 
Description Translational talk: epigenetics at the Human Genome Centre in Edinburgh (invited speaker) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact On the 4th October 2018 Prof Caroline Dean gave a talk on epigenetics at the Human Genome Centre in Edinburgh. By giving talks to fields outside of plant science the impact and application of the science will be increased. Her talk was entitled: 'Epigenetic switching and antisense transcription.'
Year(s) Of Engagement Activity 2018
 
Description Visit to Elsoms Seeds to discuss potention for doubled haploid production in research 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Visit to Elsoms seed to discuss potential for doubled haploid production in current JIC research. Outcome of providing material to Elsoms to perform a service.
Year(s) Of Engagement Activity 2019
 
Description Visit to Lister Community School, East London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact The PI (C Dean) visited the school and discussed with three cohorts of teenagers the prospects for science careers. I showed the L'Oreal video filmed at the John Innes Centre that described how the lab studies how plants monitor and remember seasons.
Year(s) Of Engagement Activity 2019
 
Description Visit to Newnham College Cambridge 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact To raise science careers as a topic to the undergraduates in this all female College
Year(s) Of Engagement Activity 2019
 
Description Visit to home educated students 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Science discussion with home educated school children
Year(s) Of Engagement Activity 2019
 
Description Women of the Future 2017 Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact The 3rd Women of the Future Conference took place on Wednesday 29th November 2017. 170 young girls from 17 schools across Norfolk and Suffolk attended the unique event. The event is specifically aimed at Year 10 girls, and aims to raise aspirations, broaden horizons and facilitate engagement with world class scientists and leaders and promote careers in STEMM subjects.

The lack of women in STEMM careers continues to be a real cause for concern for employers.

At the John Innes Centre we are committed to promoting equality and diversity for all our staff and students and in addition recognise the importance of inspiring the next generation of female STEMM professionals.

Having first been launched in 2015, this year's event built on the success of the previous two conferences, giving the participants a great chance to meet and speak with more than 27 female role models and exhibitors from a diverse range of industries.

There was also fascinating line-up of speakers that included science author and presenter Dr Emily Grossman, Senior Advisor for Medical Applications at CERN Dr Manjit Dosanjh, and JIC Research Fellow Dr Philippa Borrill.
Year(s) Of Engagement Activity 2017
URL https://www.jic.ac.uk/blog/women-of-the-future-2017/
 
Description Women of the Future Conference 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact The Women of the Future 2018 event took place with 200 girls from yr 10 (14-15 yr olds)

5 GEN female people involved:
-Speakers Jemima Brinton & Mikhaela Neequaye (Jemima is a researcher in crop genetics, Mikhaela is a Phd student in food nutrition). Science Chat on the Sofa with Speakers (Auditorium) -Chaired by Samantha Fox
-Closing Remarks - Samantha Fox
-Meet a professional session: Mikhaela Neequaye, Natalie Wager, Jess Hughes, Penny Hundleby
Year(s) Of Engagement Activity 2018
URL https://www.jic.ac.uk/blog/the-story-of-women-of-the-future-2018/
 
Description Year 10 Science Camp 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact We introduced year 10 science students to life as a scientist and working in our labs.
Year(s) Of Engagement Activity 2019
URL https://www.jic.ac.uk/training-careers/work-experience/year-10-science-camp/
 
Description YouTube video created: Evolutionary Genetics of Snapdragons 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact 'A Flying Visit to the Antirrhinum Hybrid Zone in the Pyrenees'
Take a tour through the hybrid zone in the Pyrenees where a population of magenta Antirrhinum pseudomajus on the east meets a yellow Antirrhinum striatum population to the west and form a rainbow of hybrid flowers over a 1km stretch. Read about how our study of this region revealed how small RNA helps maintain diversity in the region. The video creates interest and communicates to the general public the research that takes place in the Coen Lab.
Year(s) Of Engagement Activity 2017
URL https://www.youtube.com/watch?v=muP7fSn1eaE&feature=youtu.be
 
Description YouTube video: 'How plants plan for all seasons' 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A YouTube video: 'How plants plan for all seasons' was produced by the Dean and Irwin Lab. The video had received over 1000 views through the JIC twitter account and the JIC YouTube channel on the 13.03.19.
Year(s) Of Engagement Activity 2018
URL https://www.youtube.com/watch?v=ZnCPKI7vZck
 
Description YouTube video: movie explaining the relationship between growth and division in plants 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Sam Fox (Coen Lab) and Ruby O'grady in our communications team created a video explaining the relationship between growth and division in plants after a new model was published. The video had 1587 views from the JIC tweet alone on 13.03.19 and another 250 on the JIC YouTube Channel.
Year(s) Of Engagement Activity 2018
URL https://www.youtube.com/watch?v=bvXBYL7WUDA
 
Description Youth STEMM Award mid-term conference 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact 80 students from 8 schools in Norfolk and Suffolk attended the Youth STEMM award mid-term conference on the 26th February 2019. There were 2 talks from John Innes Centre scientists and 10 interactive stands including the Coen Lab, who displayed a range of plants and research, explaining to the students what they do for their job. Feedback from the event indicated that 95% of those that completed a feedback form (53/80) felt the event was informative as it highlighted a range of different STEMM careers out there. 80% said the event had made them inspired to pursue a STEMM related career, or take a STEMM subject at higher education. ""This exhibit has inspired me to take a higher education level in biology or as a job."
Year(s) Of Engagement Activity 2019
 
Description Youth STEMM Mid Term conference 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact On the 6th March 12 schools with 146 students (aged 13-17) participated in the YSA midterm conference at the JIC Conference Centre. The event had a combination of science talks and interactive activities as a part of the STEMM showcase. The Coen lab exhibited their research on evolution, development of shape and form and genetics at the event.
Year(s) Of Engagement Activity 2018