Dynamics of mean gain and variance analysis

Lead Research Organisation: University of Edinburgh
Department Name: UNLISTED

Abstract

The proposed research in quantitative genetics is concerned with genetic change (?G) and associated risks, such as introducing genetic diseases, related to the rate of inbreeding (?F). The approach taken will be to exploit the concept of a long-term genetic contribution of an ancestor that has been largely developed in our laboratory. It has provided a unifying concept and provided solutions to many long-standing genetic problems. The issues addressed will be: near-random mating where the benefits of mating will be combined into two weighted components corresponding to prospective and retrospective actions; improved operational tools (including markers) that exploit the results from the near random mating; linked gene flow to underpin improved linkage disequilibrium methods; and improved predictions for non-random mating and exponential contribution models.

Publications

10 25 50
 
Description The work done on this grant has led to the development of the upper bound for achievable genetic gain for a given rate of inbreeding. This represents the highest efficiency for converting genetic variance into changes in the mean of the trait, for example during selection. It is generic for all diploid species which includes all livestock. At this optimum the most efficient selection schemes will have maximal avoidance of relatives during mating.
Exploitation Route They will be increasingly implemented by breeding programmes.
Sectors Agriculture, Food and Drink

 
Description Management of diversity in commercial breeding schemes. development of evaluation models for novel commercial traits.
First Year Of Impact 2011
Sector Agriculture, Food and Drink
Impact Types Societal

 
Description Chair of FAO Working Group on "Secondary Guidelines on Management of Small Populations at Risk"
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact Preparation for UN Global Plan of Action for Animal Genetic Resources and Interlaken Declaration in 2007
URL http://www.fao.org/docrep/010/a1404e/a1404e00.htm
 
Description Membership of Defra National Consultative Committee on Farm Animal Genetic Resources, 2001 to 2002
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact UK Country Report on Farm Animal Genetic Resources 2002. This was the first time this policy area was addressed and formed an international report to FAO.
URL https://www.gov.uk/government/publications/uk-country-report-on-farm-animal-genetic-resources-2002
 
Description Membership of EAAP Working Group on Animal Genetic Resources
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact Informing EU policy on regulations and incentives for managing farm animal genetic resources.
 
Description Membership of FAO Drafting Group for 3rd Intergovernmental Technical Working Group, 2003
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact Drafting resolutions for UN inter-governemental meeting on agricultural policies, ultimately leading to UN's Global Plan of Action for Farm Animal Genetic Resources and the Interlaken Agreement in 2007.
URL http://www.fao.org/docrep/010/a1404e/a1404e00.htm
 
Description Membership of FAO Working Group on Ex Situ Conservation of Livestock
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact Preparation for UN Global Plan of Action for Animal Genetic Resources and the Interlaken Declaration in 2007.
URL http://www.fao.org/docrep/010/a1404e/a1404e00.htm
 
Description Membership of FAO Working Group on In Situ Conservation of Livestock
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact Preparation for UN Global Plan of Action for Animal Genetic Resources and the Interlaken Declaration in 2007.
URL http://www.fao.org/docrep/010/a1404e/a1404e00.htm
 
Description Membership of FAO/ISZ Working Group on Implications of Developments in Biotechnology for the Conservation of Animal Genetic Resources at Risk: Reversible DNA Quiescence and Cloning.
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact Informed UN of scientific background to the existing cloning technology, separating fact from fiction.
 
Description INIA 
Organisation National Institute for Agricultural and Food Research and Technology
Country Spain 
Sector Public 
PI Contribution Training, design and interpretation of studies, writing papers for journals
Collaborator Contribution Personnel, funding for personnel, scientific discussion, writing papers.
Impact Scientific papers. New PhDs and trained post-docs in Spain.
Start Year 2008
 
Description Norwegian University of Life Sciences (NMBU), Aas, Norway 
Organisation Norwegian University of Life Sciences (NMBU)
Country Norway 
Sector Academic/University 
PI Contribution Supervised and lectured to postgraduate students. Provided intellectual input into science proposals, ongoing projects and outputs, including research papers.
Collaborator Contribution Facilities, students, intellectual stimulation, new project ideas, data, and other academic outputs such as scientific papers.
Impact Joint scientific papers. Joint scientific projects (UoE/NMBU).
 
Description University of Leon 
Organisation University of Leon
Country Spain 
Sector Academic/University 
PI Contribution Training, design and interpretation of studies.
Collaborator Contribution Personel. Funding for personnel.
Impact Training, papers, new PhDs.
Start Year 2008
 
Description University of Osijek 
Organisation University of Osijek
PI Contribution Training of post-graduate student for a PhD. provison of data.
Collaborator Contribution Personnel and funding required.
Impact Evaluation models for boar taint to be used in selection. Training in breeding for a Croatian PhD.
Start Year 2010