A Calibration Free Continuous Invasive Sensor Targeted at Glycaemic Control in the ICU
Lead Research Organisation:
University of Bath
Department Name: Chemistry
Abstract
The development of an invasive fibre optic continuous glucose sensor/monitoring system is in direct response to the clinical need demonstrated by the seminal clinical study of Van Den Berghe et al. which was published in 2001. This study demonstrated that when the elevated glucose levels, usually experienced by Intensive Care Patients, were brought back and held within normal glucose levels by the continuous administration of insulin (Tight Glycaemic Control [TGC]), then patient mortality was reduced by 40% and morbidity by 37-46%. This reduction in morbidity was reflected in a reduction of the patient length of stay in the Intensive Care Unit thus providing additional economic benefits. The patient benefits described were achieved on the trial by intensively measuring and maintaining patient glucose levels intermittently-a maximum of hourly. Although the global ICU community have attempted to introduce TGC they have only introduced with relaxed limits (and hence achieved reduced benefits) because hourly monitoring of glucose in a typical ICU is not achievable and the fear is that during the blind interval between blood samples the adminstration of continuous insulin will push the patient into hypoglcaemia with catastrophic consequences. The development of an invasive continuous optical glucose sensor/monitor that provides real time data is aimed at enabling TGC and maximising patient and economic benefit. The development of a lifetime based system, that has a use model that is calibration free, will maximise market penetration and facilitate TGC benefits globally.
Organisations
Publications
D'Hooge F
(2012)
Biotinylated boronic acid fluorophore conjugates: Quencher elimination strategy for imaging and saccharide detection
in RSC Advances
Nishiyabu R
(2011)
Boronic acid building blocks: tools for self assembly.
in Chemical communications (Cambridge, England)
Sun X
(2016)
Boronic acids for fluorescence imaging of carbohydrates.
in Chemical communications (Cambridge, England)
Zhai W
(2015)
Boronic Acid-Based Carbohydrate Sensing.
in Chemistry, an Asian journal
Zhai W
(2016)
"Click-fluors": triazole-linked saccharide sensors
in Organic Chemistry Frontiers
Description | A commercial continuous glucose sensor/monitor that provides real time data has been developed. The sensor enables Tight Glycaemic Control (TGC) for control of glucose levels in patients in Intensive Care Units (ICUs), maximizing both patient and economic benefit. |
First Year Of Impact | 2010 |
Sector | Chemicals,Healthcare |
Impact Types | Societal,Economic |
Title | GLUCOSE SENSOR MOLECULE |
Description | The present invention provides a glucose sensor having a glucose receptor containing a binding site of formula (I): wherein X, n, m and R1 are defined herein. Also provided is a glucose sensor molecule for use in such a glucose sensor, the glucose sensor molecule containing the binding site of formula (I). The binding site has been found to have particularly good selectivity for glucose. |
IP Reference | WO2012095628 |
Protection | Patent granted |
Year Protection Granted | 2012 |
Licensed | No |
Impact | Sensor has been developed by Glysure Ltd www.glysure.com |