Arteries and Algorithms: Computational physiological flow and arterial disease modelling

Lead Research Organisation: Imperial College London
Department Name: Dept of Aeronautics

Abstract

Cardiovascular disease, including atherosclerosis, accounts for almost 50% of deaths in the western world. Our understanding of the causes and progression of atherosclerosis is relatively limited and, in many cases, both diagnosis and treatment require invasive patient specific techniques.An enhanced understanding of the physiological factors related to cardiovascular disease would likely to lead to significant advances in treatment as well as increased accuracy in diagnosis and prognosis. Developing this understanding is particularly difficult because of the complexities of the flow in human arterial networks. These are impossible to understand using existing medical data and expertise alone.Recent developments in numerical methods including greater opportunities for wider use of computational simulation and visualisation can provide the necessary link between patient specific imaging data, physics and biology, to provide a platform for this increased understanding. The impact of the use of these techniques could revolutionise medical science and practice in the way imaging modalities such as X-ray, ultrasound and magnetic resonance have done in succession over the past 40 years.The aim of this research initiative is, through close collaboration with vascular biologists, physiologists and surgeons, to develop a simulation environment capable of capturing the multi-scale, hierarchically coupled nature of both physiological and pathological arterial networks. The research programme is focused around three projects, two physiological incorporating the multiscale nature of arterial networks and one numerical: The first project will apply modelling of the three-dimensional fluid dynamics at arterial branches to improve understanding of the causal relationship of blood flow to arterial disease such as atherosclerosis. The second project is directed towards understanding and modelling pulsatile flow wavefoms in patient specific vascular networks using one-dimensional reduced models. The third project focuses on development of advanced mathematical and numerical techniques, such as uncertainty modelling and spectral/hp element methods, to facilitate such modelling.

Publications

10 25 50

publication icon
Alastruey J (2009) Analysing the pattern of pulse waves in arterial networks: a time-domain study in Journal of Engineering Mathematics

publication icon
Alastruey J (2008) Reduced modelling of blood flow in the cerebral circulation: Coupling 1-D, 0-D and cerebral auto-regulation models in International Journal for Numerical Methods in Fluids

publication icon
Alastruey J (2010) Reply to 'cord clamp insult may predispose to SIDS'. in Early human development

publication icon
Ali RL (2015) Automated fiducial point selection for reducing registration error in the co-localisation of left atrium electroanatomic and imaging data. in Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

publication icon
Cantwell C (2015) Nektar++: An open-source spectral/ h p element framework in Computer Physics Communications

 
Description BHF Project Grant
Amount £175,030 (GBP)
Funding ID PG/08/053/25192 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2008 
End 09/2011
 
Description BHF Project Grant
Amount £189,168 (GBP)
Funding ID PF/09/088 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2010 
End 09/2012
 
Description BHF Research Excellence Centre
Amount £8,900,000 (GBP)
Funding ID BHF RE/08/002 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2008 
End 03/2013
 
Description EC: IDIHOM
Amount £196,452 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 07/2010 
End 06/2013
 
Description EPSRC: LIbHPC I
Amount £483,099 (GBP)
Funding ID EP/I030239/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 07/2011 
End 06/2013
 
Description EPSRC: LIbHPC II
Amount £726,567 (GBP)
Funding ID EP/K038788/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 07/2013 
End 06/2015
 
Description EPSRC: Streak Instability
Amount £353,257 (GBP)
Funding ID EP/F045093/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 07/2008 
End 06/2011
 
Title Nektar++ v 4.0 
Description An openware spectral element framework for transient problems such as fluid mechanics 
Type Of Technology Software 
Year Produced 2008 
Open Source License? Yes  
Impact The software is being used by a number of national and international groups and our web site is currently being visited up to 100 times a day according to google analytics 
URL http://www.nektar.info