SONOPTICS: EXPLOITING ULTRASOUND AND LASER SCIENCES FOR GENERIC NON-INVASIVE THERAPIES

Lead Research Organisation: University of Dundee
Department Name: Electronic Engineering and Physics

Abstract

The objective of this Basic Technology proposal is to revolutionise the delivery of genes, drugs and therapeutic molecules to single cells and tissue samples. We will use a unique marriage of concepts extracted from ultrasonics and photonics that are intrinsically generic in applicability. This new field will deliver unprecedented accuracy and control for delivery, together with improved efficacy and selectivity, and a much reduced risk of infection. This research will lead to a quantum leap for biologists who are studying the cell's chemical pathways or signals (cellular signal transduction) through to histological/clinical approaches. For example within a population of cells it will be possible to target each cell individually, introducing foreign biological material into any cell. This is central for studies in numerous human diseases. By the use of fibre optic delivery and endoscopes, we envisage that the realisation of this basic technology may allow us to develop a non-invasive surgical technique.

Publications

10 25 50

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Campbell P (2007) Future directions for therapeutic ultrasound. in Ultrasound in medicine & biology

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Stevenson DJ (2010) Single cell optical transfection. in Journal of the Royal Society, Interface

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Tachibana K (2008) Sonodynamic therapy. in Ultrasonics

 
Description This project aimed to push the limits of microbubbles excitation for medical application, principally for molecular delivery, but also to create a means of ablative therapy, and also to test the concept of light production from violently cavitating bubbles.
We proved that light from microscopic bubbles that were excited using ultrasound energy could be harnessed for real practical use, even at high (body) temperature.
We also demonstrated that light could be used to trap and control microscopic bubble ensembles.
We also developed a new and enhanced means of imaging in the sub microsecond framing regime.
Exploitation Route patents arising have been generated and may be licensed to Cordin. Discussions to that end have already occurred with CTO Cordin.
A new grant was also successful to the Wellcome Trust fro some £5.9m.
Sectors Healthcare

URL http://www.cicass.net
 
Description In generating IP, and opening dialogue with the global leader in rotating mirror camera production, Cordin in Salt Lake City Utah, we have moved into the possibility of licensing our patented technology arising from this grant
First Year Of Impact 2011
Sector Aerospace, Defence and Marine,Education
Impact Types Cultural

 
Description EPSRC
Amount £964,449 (GBP)
Funding ID EP/H045368/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 10/2010 
End 09/2014
 
Description EPSRC
Amount £51,648 (GBP)
Funding ID EP/F013655/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 10/2007 
End 06/2008
 
Description EPSRC
Amount £51,648 (GBP)
Funding ID EP/F013655/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 10/2007 
End 06/2008
 
Description EPSRC
Amount £964,449 (GBP)
Funding ID EP/H045368/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 10/2010 
End 09/2014
 
Description Medical Research Council
Amount £624,960 (GBP)
Funding ID G0801742 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2009 
End 08/2012
 
Description Medical Research Council
Amount £89,112 (GBP)
Funding ID G0802645 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2009 
End 08/2010