FLIC - Functional Ligands for Imaging in Cancer
Lead Research Organisation:
Newcastle University
Department Name: Northern Institute for Cancer Research
Abstract
Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) are two essential imaging methods whose clinical application in cancer research is well established. Recent advances in clinical instrumentation have resulted in equipment with improved resolution and sensitivity. However, current contrast or imaging agents for use in MRI and PET are not as effective for the 21st century instrumentation now being deployed. The design, synthesis and validation of improved, new functional imaging probes is urgently needed. To develop such probes for cancer a multidisciplinary team is required with expertise in synthetic chemistry and radiochemistry, pre-clinical and clinical imaging sciences, and cancer drug development, working in harmony with the needs and aspirations of cancer biology. No single grouping in the UK can currently offer this range of expertise, and therefore to make progress in this important area the formation of a multi-centre collaborative grouping is essential. The proposed FLIC platform grant will establish a collaborative team with strengths in chemistry, cancer imaging and drug development, and in so doing create a chemistry-life science interface that will address a key need in personalised medicine, producing new chemical entities with genuine utility for healthcare providers and amenable to commercial exploitation.
Publications
Chalmers KH
(2011)
Strategies to enhance signal intensity with paramagnetic fluorine-labelled lanthanide complexes as probes for 19F magnetic resonance.
in Dalton transactions (Cambridge, England : 2003)
Chalmers KH
(2010)
Design principles and theory of paramagnetic fluorine-labelled lanthanide complexes as probes for (19)F magnetic resonance: a proof-of-concept study.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Chalmers KH
(2011)
19F-lanthanide complexes with increased sensitivity for 19F-MRI: optimization of the MR acquisition.
in Magnetic resonance in medicine
Yan Ran
(2009)
THE FIRST SYNTHESIS OF ETHYL 3-[
18F]FLUOROBENZOATE USING [
18F]FLUORIDE
in JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
Yan Ran
(2009)
THE FIRST SINGLE-STEP-SINGLE-POST SYNTHESIS OF 4-[
18F]SFB
in JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
Yan Ran
(2008)
The first preparation of all regioisomers of ethyl [
18f]fluorobenzoates
in JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
Description | Cancer Research UK |
Amount | £2,200,000 (GBP) |
Funding ID | C29821/A10348 |
Organisation | Cancer Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 12/2008 |
End | 03/2016 |
Description | Univeristy of Durham |
Organisation | University of Bath |
Department | Department of Chemistry |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Joint grantee on Programme |
Collaborator Contribution | Joint grantee |
Impact | See publications |
Start Year | 2008 |
Description | Interaction with pharma and biotech |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | Contacts with numerous pharma and boitech employees Clinical trials on novel agents with imaging endpoints brought to Newcastle |
Year(s) Of Engagement Activity | 2009,2010,2011,2012,2013,2014 |