FLIC - Functional Ligands for Imaging in Cancer

Lead Research Organisation: Newcastle University
Department Name: Northern Institute for Cancer Research

Abstract

Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) are two essential imaging methods whose clinical application in cancer research is well established. Recent advances in clinical instrumentation have resulted in equipment with improved resolution and sensitivity. However, current contrast or imaging agents for use in MRI and PET are not as effective for the 21st century instrumentation now being deployed. The design, synthesis and validation of improved, new functional imaging probes is urgently needed. To develop such probes for cancer a multidisciplinary team is required with expertise in synthetic chemistry and radiochemistry, pre-clinical and clinical imaging sciences, and cancer drug development, working in harmony with the needs and aspirations of cancer biology. No single grouping in the UK can currently offer this range of expertise, and therefore to make progress in this important area the formation of a multi-centre collaborative grouping is essential. The proposed FLIC platform grant will establish a collaborative team with strengths in chemistry, cancer imaging and drug development, and in so doing create a chemistry-life science interface that will address a key need in personalised medicine, producing new chemical entities with genuine utility for healthcare providers and amenable to commercial exploitation.

Publications

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Yan Ran (2009) THE FIRST SYNTHESIS OF ETHYL 3-[F-18]FLUOROBENZOATE USING [F-18]FLUORIDE in JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

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Yan Ran (2008) The first preparation of all regioisomers of ethyl [(18)f]fluorobenzoates in JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

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Yan Ran (2009) THE FIRST SINGLE-STEP-SINGLE-POST SYNTHESIS OF 4-[F-18]SFB in JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

 
Description Cancer Research UK
Amount £2,200,000 (GBP)
Funding ID C29821/A10348 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2008 
End 03/2016
 
Description Univeristy of Durham 
Organisation University of Bath
Department Department of Chemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Joint grantee on Programme
Collaborator Contribution Joint grantee
Impact See publications
Start Year 2008
 
Description Interaction with pharma and biotech 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Contacts with numerous pharma and boitech employees

Clinical trials on novel agents with imaging endpoints brought to Newcastle
Year(s) Of Engagement Activity 2009,2010,2011,2012,2013,2014