Achieving 1,4-Additions to 'Impossible' Substrates

Lead Research Organisation: University of Nottingham
Department Name: Sch of Chemistry


There are no examples of catalytic aymmetric 1,4-additions of Grignard reagents (RMgX) to unsaturated amides (Case 1) despite the high synthetic utility that this transformation would offer. Similarly, no catalytic addition of a diorganozinc species (ZnR2) to an unsaturated esters (Case 2) has ever been reported. In collaboration with DowPharma we have recently uncovered the first examples of these two transformations. We wish to carry out a highly focused proof of application study for these remarkable reactions.
Description Chirotech Technology Limited 
Organisation Chirotech Technology
Country United Kingdom 
Sector Private 
Start Year 2007