Achieving 1,4-Additions to 'Impossible' Substrates
Lead Research Organisation:
University of Nottingham
Department Name: Sch of Chemistry
Abstract
There are no examples of catalytic aymmetric 1,4-additions of Grignard reagents (RMgX) to unsaturated amides (Case 1) despite the high synthetic utility that this transformation would offer. Similarly, no catalytic addition of a diorganozinc species (ZnR2) to an unsaturated esters (Case 2) has ever been reported. In collaboration with DowPharma we have recently uncovered the first examples of these two transformations. We wish to carry out a highly focused proof of application study for these remarkable reactions.
People |
ORCID iD |
| S Woodward (Principal Investigator) |
Publications
Bernier D
(2009)
Properties, Preparation and Synthetic Uses of Amine N -Oxides. An Update
in Organic Preparations and Procedures International
Biswas K
(2008)
Stereoselective 1,4-addition of Grignard reagents to a,ß-enamides using a combined chiral auxiliary-catalyst approach
in Tetrahedron: Asymmetry
Blake A
(2007)
In Search of New Approaches to Asymmetric Conjugate Addition: Screening Studies on the Use of [Zn(bpy*)X(R)] Reagents and a,ß-Unsaturated Amide Michael Acceptors
in Collection of Czechoslovak Chemical Communications
Mata Y
(2007)
Sugar-phosphite-oxazoline and phosphite-phosphoroamidite ligand libraries for Cu-catalyzed asymmetric 1,4-addition reactions
in Tetrahedron: Asymmetry
N/a Glynn
(2008)
Asymmetric aryl addition to aldehydes
Wefelscheid UK
(2009)
Rearrangement of beta-chloro N-oxides to hydroxylamines: opening of the oxazetidinium intermediate by different nucleophiles.
in The Journal of organic chemistry
| Description | Chirotech Technology Limited |
| Organisation | Chirotech Technology |
| Country | United Kingdom |
| Sector | Private |
| Start Year | 2007 |