PROSPEcT: Ecotoxicology test protocols for representative nanomaterials in support of the OECD sponsorship programme

Lead Research Organisation: UNIVERSITY OF EXETER
Department Name: Biosciences

Abstract

The proposed research forms an integral part of the PROSPEcT LINK project, initiated through the 'Nanoscience through Engineering to Application' programme. The project aims to provide a direct contribution to the global safety assessment of nanomaterials described by the OECD Working Party on Manufactured Nanomaterials (WPMN). The LINK project will develop essential and seminal test methods and data on two agreed nanomaterials that are of particular commercial relevance to the UK. The project will innovate the scientific foundations for adapting or creating test methods that enable the ecotoxicological hazard assessment of nanomaterials. Both particles (i.e. CeO2 and ZnO) are part of a list of 14 nanomaterials, identified as commercially relevant to the global economic impact of nanotechnology. Furthermore, the development of methods to characterize CeO2 and ZnO nanomaterials in concert with parallel and coordinated development for other nanomaterials across the OECD testing program will enablethe future establishment of QSARs (Quantitative Structure Activity Relationships) for predictive safety evaluations of novel nanomaterials.The resulting scientific advancement will help to secure an economic future for the commercialisation of nanotechnologies in and by the UK and provide crucial UK leadership and information to the OECD's global programme on nanomaterials safety assessment.
 
Description This project has:
1. Provided a thorough review and evaluation o characterisation, toxicological and ecotoxicological data available on nano-CeO2 and ZnO, as well as methodologies that might be used to conduct tests that address the OECD
endpoints.
2. Created a detailed Test Dossier for the OECD endpoints testing of nano-CeO2 and nano-ZnO (including assignment of characterisation, tests, and methodologies to be developed during the PROSPEcT LINK project) within which nano-specific properties may be described.
3. Provided detailed sampling, handling and testing protocols for nano-ZnO and nano-CeO2, with a view to sharing the protocols with the OECD Sponsorship Programme for alignment with other nanomaterials test protocols.
4. Established the proof-of-principle for new techniques to detect nanoparticles against the background, including the exploitation of established techniques through prototyping of instruments.
5. Comprehensively address the the OECD endpoints for ecotoxicology on nano- CeO2 and ZnO, laying the foundation for understanding nano-specific behaviour and the risk management context of subsequent OECD and UK data
development efforts.
Exploitation Route This fundamental work could readily be taken forward into the further development of environmental risk assessment procedures for application to manufactured nanmaterials in environmental media: for example natural waters and sediments
Sectors Agriculture

Food and Drink

Chemicals

Construction

Environment

 
Description This project picked up from the seminal work and recommendations of the UK Royal Society & Royal Academy of Engineering report on the opportunities and challenges posed by nanotechnologies and has provided a direct contribution to the global safety assessment of nanomaterials described by the OECD Working Party on Manufactured Nanomaterials (WPMN). It has developed essential and seminal test methods and fundamental data on two agreed nanomaterials that are of particular commercial relevance to the UK. The project has innovated the scientific foundations for adapting or creating test methods that enable the ecotoxicological hazard assessment of nanomaterials. Both particles (CeO2 and ZnO) are part of a list of 14 nanomaterials, identified as commercially relevant to the global economic impact of nanotechnology. Furthermore, the development of methods to characterize CeO2 and ZnO nanomaterials in concert with parallel and coordinated development for other nanomaterials across the OECD testing program has set the foundations for the future establishment of QSARs (Quantitative Structure Activity Relationships) for predictive safety evaluations of novel nanomaterials. The resulting scientific advancement will help to secure an economic future for the commercialisation of nanotechnologies in and by the UK and provide crucial UK leadership and information to the OECD's global programme on nanomaterials safety assessment.
First Year Of Impact 2014
Sector Agriculture, Food and Drink,Chemicals,Construction,Environment
Impact Types Societal

Economic

Policy & public services

 
Description Gave evidence to a government review, POST note on Trends in the Environment
Geographic Reach National 
Policy Influence Type Citation in other policy documents
Impact Identifies marine microplastics as an internationally important emerging issue of environmental concern for policymakers, cites our papers as evidence
URL http://researchbriefings.parliament.uk/ResearchBriefing/Summary/POST-PN-0516
 
Description citation as evidence in government POST note on microplastics 2016
Geographic Reach National 
Policy Influence Type Contribution to a national consultation/review
Impact I contributed to the Government POST note on microplastics, both contributing as a reviewer and having our published work cited in the review. Papers cited include DOI: 10.1021/es400663f, DOI: 10.1021/es400663f, THis POST note provides detailed evidence for policymakers on how microplsatics may be impacting the marine environment and human health.
URL http://researchbriefings.parliament.uk/ResearchBriefing/Summary/POST-PN-0528
 
Description Dept for Env Food & Rural Affairs DEFRA
Amount £23,250 (GBP)
Funding ID LK0852 
Organisation Department For Environment, Food And Rural Affairs (DEFRA) 
Sector Public
Country United Kingdom
Start 07/2011 
End 12/2011
 
Description Dept for Env Food & Rural Affairs DEFRA
Amount £23,250 (GBP)
Funding ID LK0852 
Organisation Department For Environment, Food And Rural Affairs (DEFRA) 
Sector Public
Country United Kingdom
Start 07/2011 
End 12/2011
 
Description European Union EU Brussels
Amount £220,000 (GBP)
Funding ID 262163 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 09/2011 
End 09/2014
 
Description European Union EU Brussels
Amount £220,000 (GBP)
Funding ID 262163 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 09/2011 
End 09/2014
 
Description European Union EU Brussels
Amount £530,000 (GBP)
Funding ID 310451 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 09/2013 
End 09/2015
 
Description European Union EU Brussels
Amount € 530,000 (EUR)
Funding ID 310451 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 09/2013 
End 09/2015
 
Description NERC Grouped
Amount £24,000 (GBP)
Funding ID FENAC/2010 
Organisation Natural Environment Research Council 
Sector Public
Country United Kingdom
Start 03/2010 
End 03/2011
 
Description NERC Grouped
Amount £24,000 (GBP)
Funding ID FENAC/2011/05/001 
Organisation Natural Environment Research Council 
Sector Public
Country United Kingdom
Start 03/2011 
End 03/2012
 
Description NERC Grouped
Amount £24,000 (GBP)
Funding ID FENAC/2011/05/002 
Organisation Natural Environment Research Council 
Sector Public
Country United Kingdom
Start 03/2011 
End 03/2012
 
Description NERC Grouped
Amount £203,000 (GBP)
Funding ID EPA-G2008-STAR-R1 
Organisation Natural Environment Research Council 
Sector Public
Country United Kingdom
Start 09/2011 
End 09/2014
 
Description NERC Grouped
Amount £24,000 (GBP)
Funding ID FENAC/2011/05/003 
Organisation Natural Environment Research Council 
Sector Public
Country United Kingdom
Start 03/2011 
End 03/2012
 
Description I attended the Royal Society of Chemistry Environmental Nanoscience Initiative event on 10th December 2015 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I attended the Royal Society of Chemistry Environmental Nanoscience Initiative event on 10th December 2015. This was designed to showcase the grants funded under the scheme and engage with the nanoindustry community
Year(s) Of Engagement Activity 2015