Multi-marker Nanosensors for HIV

Lead Research Organisation: University College London
Department Name: London Centre for Nanotechnology

Abstract

Our mission is to establish a world-leading consortium to engineer and commercialise the next generation of multi-marker HIV smart chips to rapidly diagnose, stage and monitor HIV in resource-limited environments, including district hospitals, GP surgeries and developing countries. This Grand Challenge is a large scale multidisciplinary joint venture between scientists at the London Centre for Nanotechnology (UCL/Imperial), clinical virologists in the UCL/MRC Centre for Medical Molecular Virology, Royal Free and UCL Hospitals, the DoH-funded Comprehensive Biomedical Research Centre at UCLH NHS Trust, in conjunction with the Health Protection Agency and industrial partners Cambridge Medical Innovations, Sphere Medical Ltd and the BionanoConsulting. Our novel nanodiagnostic & monitoring device builds on our remarkably strong multidisciplinary, entrepreneurial team of scientists, engineers and clinicians, and a series of recent breakthroughs by our team in diverse fields, including nanomechanical sensing in serum, nanofabrication, nanosorting, magnetism, nanoparticles, optical devices and novel single domain llama antibodies. The radical step change we now seek to implement, seamlessly integrates the scientific promise of these advances, to sort and sense very low copy number HIV markers, via magnetically driven force rupture, ultimately towards the single marker level:Sorting: The patient's blood sample will be mixed with superparamagnetic nanoparticles, which have been functionalised with capture antibodies specific to each marker. Tagged-viruses will be concentrated from blood by applying a magnetic field gradient (produced by a miniature induction coil) & sorted from the naked nanoparticles by flowing them through a nanostructured array of passivated pillars, designed such that particles of different size follow distinct trajectories. This variant of a proven method, pioneered by co-I Tom Duke and USA collaborators, for separation of microspheres within minutes requires submicron features which can comfortably be achieved using e-beam lithography at the LCN. It also has the advantage that it will concentrate the markers, which will enhance our device sensitivity and reduce the volume of patient blood required. Nanosorting of multi-marker CD4 cells, virions, antibodies and p24 proteins which have vastly different sizes, ranging from 5 um to 5 nm, will be achieved in parallel by clever tagging and nanopillar gradient designs.Sensing: Tagged markers will then be detected on cantilevers tailored with capture proteins, using optimised covalent linker chemistry. The maximum sensitivity will be achieved by scaling down the dimensions of the cantilever beam from the current mesoscopic scale to submicron widths, comparable to just a few virions, and a relatively unexplored sensing mechanism, based on magnetic actuation, which promises to improve the sensitivity by many orders of magnitude, towards the single marker level, where we can take advantage of stochasicity. We point out that while this technology has been proposed a long time ago, it has not found its way into the clinic because of the lack of careful and repetitive measurements on medically relevant targets. Readout: Changes in cantilever deflection and/ or resonance will be read using novel optical transmission methods pioneered at the LCN, which simply treats the cantilever as a diffractive object and measures bending of multiple cantilevers using a CCD camera. The real advantages of this approach are that multiple arrays can be measured in parallel, there is no complex laser alignment or on-chip wiring procedures, and the laser detector distance can be significantly miniaturized.The development of our handheld HIV multiple-marker device will ultimately result in more effective management of HIV infection, thereby significantly improving the prospects of millions of HIV infected people across the world.
 
Description With EPSRC funding we have engineered nano sensors to diagnose HIV. This Grand Challenge grant was a large scale multidisciplinary joint venture between scientists at the London Centre for Nanotechnology (UCL/Imperial), clinical virologists in the UCL/MRC Centre for Medical Molecular Virology, Royal Free and UCL Hospitals and the Department of Health funded Comprehensive Biomedical Research Centre at UCLH NHS Trust. Research highlights included novel llama antibodies against HIV, cantilever sensors for infectious diseases, a novel diffractive cantilever readout and device prototype, microfluidic devices to sort and separate complex biological samples. The work resulted in several high impact publications (including Nature Nanotechnology) and patents.
Exploitation Route The findings of this Grand Challenge Award were taken forward in several different ways
- the nano bodies are being taken forward for early HIV diagnosis as part of an NIHR i4i grant and EPSRC IRC
- the cantilever diffractive readout method is being taken forward by Bio Nano Consulting
Sectors Healthcare,Pharmaceuticals and Medical Biotechnology

 
Description Early diagnosis of HIV is the gateway to treatment and care, leading to major human and economic benefits. However in the UK one in five people are unaware of their infection. Novel capture coatings arising from this Grand Challenge Programme are being taken forward into early stage HIV diagnostic product development with a commercial partner. The cantilever nanosensor technology developed in this project have led to impact in other disease areas - namely antimicrobial resistance. The findings have contributed to our understanding of how glycopeptide antibiotics kill bacteria, such as MRSA and led to high impact publications in Nature Nanotechnology.
Sector Healthcare
Impact Types Societal,Policy & public services

 
Description McKendry participated in the closed EPSRC panel addressing the importance of long term investment in engineering and physical sciences in the UK
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description McKendry was invited to be in NIHR i4i panel
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Prof McKendry Cross Council Antimicrobial Resistance Steering Committee
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact Shaping policy on AMR
 
Description Prof McKendry Invited to Blackett Review Panel on Biodetection
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Prof McKendry Invited to Prime Ministers Council for Science and Technology meeting- discussed key questions around convergence between materials, bio and digital technologies.
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Prof McKendry, Cox and Johnson Invited to Wellcome Trust Digital Phenotypes Frontiers Meeting
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Coherent Surface X-ray Diffraction investigation of Thiol-induced structural changes in Gold
Amount £174,361 (GBP)
Funding ID EP/G068437/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 04/2010 
End 03/2014
 
Description Funding for a scientific activity
Amount £3,000 (GBP)
Organisation The Royal Society 
Sector Academic/University
Country United Kingdom
Start 04/2014 
End 05/2014
 
Description NHS Foundation Trust
Amount £96,303 (GBP)
Funding ID RCF217/VG/2015 
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 11/2015 
End 10/2016
 
Description Royal Free Charity
Amount £15,000 (GBP)
Organisation Royal Free Charity 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2016 
End 04/2017
 
Description UCL Postdoctoral Mobility Awards
Amount £20,432 (GBP)
Organisation University College London 
Sector Academic/University
Country United Kingdom
Start 11/2012 
End 04/2013
 
Description Wolfson Research Merit Award
Amount £50,000 (GBP)
Organisation The Royal Society 
Sector Academic/University
Country United Kingdom
Start  
 
Description i-sense EPSRC IRC Next Steps Plus: A Smartphone Powered mRNA Sequence Detector
Amount £1,027,001 (GBP)
Funding ID EP/R018707/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 09/2021
 
Description i-sense EPSRC IRC in Early Warning Sensing Systems for Infectious Diseases
Amount £11,057,949 (GBP)
Funding ID EP/K031953/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 10/2013 
End 09/2019
 
Description i-sense Next Steps Award: EPSRC IRC in Agile Early Warning Sensing Systems for Infectious Diseases and Antimicrobial Resistance
Amount £3,900,620 (GBP)
Funding ID EP/R00529X/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 09/2022
 
Title Cantilever Chemistry functionalisation 
Description Cantilever arrays have been used to monitor biochemical interactions and their associated stress. However, it is often necessary to passivate the underside of the cantilever to prevent unwanted ligand adsorption, and this process requires tedious optimization. Here, we show a way to immobilize membrane receptors on nanomechanical cantilevers so that they can function without passivating the underlying surface. Using equilibrium theory, we quantitatively describe the mechanical responses of vancomycin, human immunodeficiency virus type 1 antigens and coagulation factor VIII captured on the cantilever in the presence of competing stresses from the top and bottom cantilever surfaces. We show that the area per receptor molecule on the cantilever surface influences ligand-receptor binding and plays an important role on stress. Our results offer a new way to sense biomolecules and will aid in the creation of ultrasensitive biosensors 
Type Of Material Technology assay or reagent 
Year Produced 2015 
Provided To Others? Yes  
Impact This method refers to a process for immobilizing probe molecules (such as receptors or antibodies) able to interact with a ligand or drug molecule on nanomechanical cantilevers so that they can function, in a reliable, selective and sensitive way, without the need to passivate the underlying surface. By tuning the probe molecule concentration (i.e. by working in a concentration range of 1 to 1000 µM), the impact of the underlying surface self-assembeled monolayer functionalization can be minimized. Moreover, the area per probe molecule (i.e. the probe molecule spacing) on the cantilever surface which influences coupling molecule/probe molecule binding and can affect the mechanical stress and hence on the sensitivity and selectivity of the sensor. This approach has therefore yielded a cantilever having the same or even an enhanced selectivity and sensitivity with respect to the known passivated cantilevers without the drawbacks of the passivation procedure (which is lengthy and often requires tedious optimization). In another aspect, this notable aspect provides a method for detecting molecules in body fluids having improved selectivity and sensitivity. 
 
Title Cantilever nanosensors for infectious diseases and antimicrobial resistance 
Description Cantilever nanosensors for infectious diseases and antimicrobial resistance 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact Patil, S.B., Manuel V., Webb, B., Mazza, G., Pinzani, M., Soh, Y., McKendry, R.A. & Ndieyira, J.W. 'Decoupling competing surface binding kinetics and reconfiguration of receptor footprint for ultrasensitive stress assays' Nature Nanotechnology 10, 899-907 (2015); DOI: 10.1038/nnano.2015.174. Kappeler, N. 'Cantilevers for biological monitoring: opportunities for classical and quantum physics' Contemporary Physics, (2014); DOI: 10.1080/00107514.2014.966615 Ndieyira, J. W., Kappeler, N., Logan, S., Cooper M.A., Abell, C., McKendry R.A. & Aeppli, G. 'Surface-stress sensors for rapid and ultrasensitive detection of active free drugs in human serum' Nature Nanotechnology 9, 225-232 (2014); DOI: 10.1038/nnano.2014.33. Kappeler N. 'Thoughts on an education' Nature Nanotechnology 8, 794-796 (2013); DOI: 10.1038/nnano.2013.239. McKendry R.A. & Kappeler N. 'Sensors: Good vibrations for bad bacteria' Nature Nanotechnology 8, 483-484 (2013); DOI: 10.1038/nnano.2013.127. 
URL https://www.ucl.ac.uk/mathematical-physical-sciences/maps-news-publication/maps1544/
 
Title Imaging based optical diffraction method for nanofabricated cantilever 
Description Micro-mechanical transducers such as cantilevers for atomic force microscopy (AFM) often rely on optical readout methods that require illumination of a specific region of the structure. The new method explores and exploits diffraction effects previously neglected when modelling cantilever bending measurement techniques. Cantilever edge illumination causes an asymmetric diffraction pattern at the photo-detector that significantly affects the calibration of the measured signal in the popular optical beam deflection technique. The conditions for linear signals that avoid detection artefacts conflict with small numerical aperture illumination and narrow/smaller cantilevers. Embracing diffraction patterns as a physical measurable allows a more potent detection technique that decouples tilt and curvature and simultaneously relaxes the requirements on the illumination alignment and detector position through a measurable which is invariant to translation and rotation. This method offers experimental design guidelines and quantify sources of systematic errors. It offers a nanometre resolution detection ability where the diffraction effects from finite sized or patterned cantilevers are exploited. Such effects are readily generalized to arrays, and allow transmission detection of mechanical curvature, enabling instrumentation with simpler geometry. 
Type Of Material Improvements to research infrastructure 
Year Produced 2016 
Provided To Others? Yes  
Impact Imaging based optical diffraction method and the use of nanofabricated cantilever can boost the use of cantilever sensors, opportunity to multiplex and their robustness in use. This eliminates the alignment requirements and improves stability. This approach enables a much more robust method, namely far field diffractive imaging, for optical readout of cantilever arrays. The method operates with light beams which can be much larger than individual cantilevers and whose angle of incidence and reaction does not need to be precisely set and measured, thus removing the obstacles presented by optical beam deflection technique for non-expert use, miniaturization and multiplexing, and thus opening optically read- out cantilever arrays to numerous applications outside specialist research laboratories. 
 
Description QVQ 
Organisation QVQ B.V.
Country Netherlands 
Sector Private 
PI Contribution Expertise in diagnostic test development, advanced nanomaterials, molecular modelling and virology
Collaborator Contribution QVQ bring a wealth of expertise in llama antibody development
Impact Loynachan, C.N., Thomas, M.R., Gray, E.R., Richards, D.A., Kim, J., Miller, B.S., Brookes, J.C., Agarwal, S., Chudasama, V., McKendry, R.A., Stevens, M.M. 'Platinum Nanocatalyst Amplification: Redefining the Gold Standard for Lateral Flow Immunoassays with Ultrabroad Dynamic Range' ACS Nano (2017); DOI: 10.1021/acsnano.7b06229; urbé, V., Gray, E. R., Lawson, V. E., Nastouli, E., Brookes, J. C., Weiss, R. A., Pillay, D., Emery, V. C., Verrips, C. T., Yatsuda, H., Athey, D., McKendry, R. A. 'Towards an ultra-rapid smartphone- connected test for infectious diseases' Scientific Reports 7, Article number: 11971 (2017); DOI:10.1038/s41598-017-11887-6; Gray, E.R., Brookes, J.C., Caillat, C., Turbe, V., Webb, B.L., Granger, L.A., Miller, B.S., McCoy, L.E., El Khattabi, M., Verrips, C.T., Weiss, R.A., Duffy, D.M., Weissenhorn, W., McKendry, R.A. 'Unravelling the molecular basis of high affinity nanobodies against HIV p24: in vitro functional, structural and in silico insights.' ACS Infectious Diseases (2017); DOI: 10.1021/acsinfecdis.6b00189
Start Year 2012
 
Title CANTILEVER SENSORS FOR MOLECULE DETECTION 
Description Process for cantilever coating to enhance selectivity and sensitivity 
IP Reference US20170370915 
Protection Patent application published
Year Protection Granted
Licensed Commercial In Confidence
Impact For prototype development
 
Title Measurement of micro-structure curvature 
Description Descripton 
IP Reference WO2013144646 
Protection Patent granted
Year Protection Granted
Licensed Commercial In Confidence
Impact Prototype instrument developed
 
Title VHH against HIV 
Description novel capture antibodies against HIV proteins p120, p41 and p24 in partnership with QVQ 
IP Reference  
Protection Protection not required
Year Protection Granted
Licensed Commercial In Confidence
Impact novel proteins used in diagnostic test development. Publications in progress
 
Title Cantilever nanosensors to detect antimicrobial resistant bacteria 
Description Development of nano mechanical sensors to detect antimicrobial resistant bacteria and for therapeutic monitoring of antibiotics 
Type Of Technology Detection Devices 
Year Produced 2015 
Impact Patil, S.B., Manuel V., Webb, B., Mazza, G., Pinzani, M., Soh, Y., McKendry, R.A. & Ndieyira, J.W. 'Decoupling competing surface binding kinetics and reconfiguration of receptor footprint for ultrasensitive stress assays' Nature Nanotechnology 10, 899-907 (2015); DOI: 10.1038/nnano.2015.174. Kappeler, N. 'Cantilevers for biological monitoring: opportunities for classical and quantum physics' Contemporary Physics, (2014); DOI: 10.1080/00107514.2014.966615 Ndieyira, J. W., Kappeler, N., Logan, S., Cooper M.A., Abell, C., McKendry R.A. & Aeppli, G. 'Surface-stress sensors for rapid and ultrasensitive detection of active free drugs in human serum' Nature Nanotechnology 9, 225-232 (2014); DOI: 10.1038/nnano.2014.33. Kappeler N. 'Thoughts on an education' Nature Nanotechnology 8, 794-796 (2013); DOI: 10.1038/nnano.2013.239. McKendry R.A. & Kappeler N. 'Sensors: Good vibrations for bad bacteria' Nature Nanotechnology 8, 483-484 (2013); DOI: 10.1038/nnano.2013.127. McKendry, R.A. & Saxl, T.E. 'EPSRC IRC Submission of Evidence to the House of Commons Science & Technology Select Committee Inquiry into Antimicrobial Resistance' (2013). 
URL https://www.ucl.ac.uk/mathematical-physical-sciences/maps-news-publication/maps1544/
 
Title Llama antibodies against HIV and influenza biomarkers 
Description Novel llama antibodies against HIV and influenza biomarkers have been developed in partnership with QVQ, 
Type Of Technology New Material/Compound 
Year Produced 2017 
Impact Publications in progress 
URL https://www.i-sense.org.uk/research/core-research
 
Description Events : BSP Autumn Symposium 2016, Durham - Microbial protein targets: towards understanding and intervention 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Study participants or study members
Results and Impact Was invited by the organising committee of British Society for Parasitology to present at Durham University. This meeting was focused on human and animal parasites.
Year(s) Of Engagement Activity 2016
URL http://www.myeventflo.com/event.asp?evID=1905
 
Description 13th International Workshop on Nanomechanical Sensing 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Study participants or study members
Results and Impact Was invited by the organising committee to present a talk at the 13th International Workshop on Nanomechanical Sensing (NMC 2016) in Delft, The Netherlands, 22-24 June, 2016. This meeting is focussed on interdisciplinary research related to micro and nanoscale sensors.
Year(s) Of Engagement Activity 2016
URL http://www.nmc-2016.org
 
Description BBC article 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The BBC News Channel featured at article about EPSRC Grand Challenge grant, which raise the visibility of our research.
Year(s) Of Engagement Activity 2009,2012,2016
URL http://news.bbc.co.uk/1/hi/health/8034336.stm
 
Description Interview Inquiry for UCL-led new research on Antibiotics 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact This was to share the outcome of the new mode antibiotic action against resistant bacteria. This has been well received with 5000 page reviews in one month.
Year(s) Of Engagement Activity 2017
URL http://news.cncnews.cn/2017-02-15/124513343.html
 
Description Interview Inquiry for UCL-led new research on Antibiotics 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact The intended activity was to present the work on antimicrobial resistance and some of the possible ways of preventing its spread. We were delighted to see the research covered in this month's issue of the BBC's science magazine, Focus!.
Year(s) Of Engagement Activity 2017
URL http://www.bbc.co.uk/news/health-38857266
 
Description McKendry Group meeting with HIV patient group representative 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Meeting with HIV patient group representative Christopher Sandford to discuss about our i4i project and learn more about end-user needs

- better understanding of HIV patients needs
- highlighted issues of need to link to follow up care and confidentiality
Year(s) Of Engagement Activity 2014
URL https://www.i-sense.org.uk/power-patient-interview-patient-representative-chris-sandford
 
Description Prof McKendry Invited Cambridge Annual WiSETI Lecture - The Mobile Revolution: From M-Health to M-Powering Women 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Prof McKendry gave the Cambridge Annual WiSETI Lecture, Cambridge University, Cambridge, UK "The Mobile Revolution: From M-Health to M-Powering Women"
Year(s) Of Engagement Activity 2014
URL https://www.equality.admin.cam.ac.uk/projects/wiseti/wiseti-activities/annual-wiseti-lecture/past-le...
 
Description Prof McKendry Invited Speaker and Panel Member Science for a Successful Nation - Fighting Antimicrobial Resistance 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact McKendry Talk EPSRC Science for a Successful Nation EPSRC Royal Society, London Fighting Antimicrobial Resistance
Year(s) Of Engagement Activity 2014
 
Description Prof McKendry Invited Talk Rosetrees Trust 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof McKendry have a Public lecture at the UCL Rosetrees Interdisciplinary Symposium, UCL, London/UK, 2015 'Going Viral - The Digital Future of Health'
Year(s) Of Engagement Activity 2015
URL http://www.rosetreestrust.co.uk/blog/rosetreesucl-smart-technologies-for-health-symposium-2/
 
Description Prof McKendry Public Lecture at UCL IBME Medtech Week - Harnessing the Power of Nanotechnology, Mobile Phones and Big Data for Global Health 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Rachel McKendry Public lecture UCL IBME Medtech Week UCL London/UK 2015 Harnessing the Power of Nanotechnology, Mobile Phones and Big Data for Global Health
Year(s) Of Engagement Activity 2015
 
Description Prof McKendry Royal Society Rosalind Franklin Award Lecture 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact talk sparked discussion afterwards
over 7000 visits to twitter
interest from media, researchers, industry, NHS commissioner, school children
new collaborations

Malcolm Grant NHS Commissioning asked questions about mobile technologies for nhs
Year(s) Of Engagement Activity 2014
URL http://www.i-sense.org.uk/news/i-sense-director-wins-royal-society-rosalind-franklin-award-2014
 
Description Prof McKendry featured on BBC 100 women (2016) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Creation of Wikipedia research page by BBC journalist, led to increased visibility of Prof McKendry and her research team. Featured on BBC World service - see links belowhttp://www.bbc.co.uk/programmes/p04jnwtz
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/programmes/p04jnwtz
 
Description Prof McKendry talk at MAPS Festival - Connecting for Global Health: nanosensors, mobile phones and big data 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Rachel McKendry Talk MAPS Research Festival MAPS, UCL London, UK 2015-07-07 Connecting for Global Health: nanosensors, mobile phones and big data
Year(s) Of Engagement Activity 2015
 
Description YouTube - Next Generation of HIV Diagnostics 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact A short youtube film was made by the team to mark World AIDS Day 2009. The film details the aims and objectives of the EPSRC Grand Challenge grant.



http://www.youtube.com/watch?v=ko3mFhdF_Tw

http://www.youtube.com/watch?v=ko3mFhdF_Tw
Year(s) Of Engagement Activity 2009
URL http://www.youtube.com/watch?v=ko3mFhdF_Tw
 
Description engagement with FDA 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Early engagement with US medical device regulator - the FDA

Early engagement
advocacy for mobile health
Year(s) Of Engagement Activity 2013
 
Description meeting with HIV patient group i-base 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Participants in your research and patient groups
Results and Impact Meeting with i-base to understand more about HIV patients needs and open two way dialogue about needs for mobile HIV tests

- better understanding of end user needs
- future opportunities for collaboration and involvement in project
Year(s) Of Engagement Activity 2014