Investigating the Potential Of Polymer-Scaffolded Dynamic Combinatorial Libraries
Lead Research Organisation:
Newcastle University
Department Name: School of Chemistry
Abstract
We propose to develop a new, simple and low-cost method to create wholly synthetic macromolecules which can selectively recognise and bind to target molecules, or catalyse chemical reactions of interest. These macromolecules can be considered as synthetic mimics of proteins, a class of macromolecule found in all living systems which over billions of years have perfected their molecular recognition and catalytic abilities. The proposed approach to developing synthetic protein mimics involves the application of concepts from the emerging field of dynamic combinatorial chemistry, in which building blocks are self-assembled around a template molecule. The special nature of this 'molding' process provides a mechanism for optimising the interactions between the template and receptor, a significant advance over existing methods for designing receptors. The development of an effective method to create 'designer' macromolecules will be of considerable benefit in numerous applications where protein-based technologies are already important. Clinical in vitro diagnostics, for instance, are heavily reliant on sophisticated macromolecular receptors which are often expensive and difficult to produce. Our approach could allow the rapid creation of low-cost synthetic alternatives. Furthermore, our method may be useful in creating new macromolecular catalysts for reactions in which natural or engineered proteins are not efficient or simply not available. Such technology would be immensely important to the pharmaceutical and fine chemicals industries.
People |
ORCID iD |
David Fulton (Principal Investigator) |
Publications
Mahon C
(2013)
Investigating templating within Polymer-Scaffolded Dynamic Combinatorial Libraries
in Polym. Chem.
Mahon C
(2017)
Molecular Recognition-Mediated Transformation of Single-Chain Polymer Nanoparticles into Crosslinked Polymer Films
in Angewandte Chemie
Mahon C
(2013)
Templation-induced re-equilibration in polymer-scaffolded dynamic combinatorial libraries leads to enhancements in binding affinities
in Chemical Science
Mahon CS
(2014)
Mimicking nature with synthetic macromolecules capable of recognition.
in Nature chemistry
Mahon CS
(2015)
Templating carbohydrate-functionalised polymer-scaffolded dynamic combinatorial libraries with lectins.
in Organic & biomolecular chemistry
Mahon CS
(2011)
Templating a polymer-scaffolded dynamic combinatorial library.
in Chemical communications (Cambridge, England)
Mahon CS
(2017)
Molecular Recognition-Mediated Transformation of Single-Chain Polymer Nanoparticles into Crosslinked Polymer Films.
in Angewandte Chemie (International ed. in English)
Murray B
(2011)
Dynamic Covalent Single-Chain Polymer Nanoparticles
in Macromolecules
Murray BS
(2010)
Reactive thermoresponsive copolymer scaffolds.
in Chemical communications (Cambridge, England)
Whitaker DE
(2013)
Thermoresponsive dynamic covalent single-chain polymer nanoparticles reversibly transform into a hydrogel.
in Angewandte Chemie (International ed. in English)
Description | Single Polymer Chain Nanoparticles |
Organisation | Materials Physics Center (CSIC-UPV/EHU) |
Country | Spain |
Sector | Academic/University |
PI Contribution | We worked with the group of Jose Pomposo to develop new single chain polymer nanoparticles |
Collaborator Contribution | Our partners palced a student in our lab for 6 months to perform all work. |
Impact | Sanchez-Sanchez, A.; Fulton, D. A.; Pomposo, J. A. "pH-Responsive Single-Chain Polymer Nanoparticles Utilising Dynamic Covalent Enamine Bonds" Chem. Commun. 2014, 50, 1871-1874. |
Start Year | 2012 |