Biomagnetic retraction for endoscopic surgery

Lead Research Organisation: University of Dundee
Department Name: Division of Imaging & Technology

Abstract

In open surgery the surgeon may use his hands or a range of large instruments to retract organs. In Minimal Access Surgery (MAS, popularly known as 'keyhole' surgery) it is not possible to do this. Special retractors have been developed for MAS, but these do not work very effectively and may sometimes traumatise tissues and organs.This proposal is based on a previous EPSRC pilot grant, the results of which confirmed the feasibility of rendering small areas of tissue ferromagnetic: these localised ferromagnetic regions can then be retracted and manipulated using magnetic probes during MAS and recent variations on this surgical approach: natural office surgery (NOS) and single port laparoscopic surgery (SPLS). The proposed research involves the development of - a novel system for the injection of ferromagnetic media to allow magnetic retraction of bowel during MAS, SPLS and NOS. The ferromagnetic media is injected directly into the bowel and is excreted normally after the operation;- a new method for surface ferromagnetisation of tissues by developing novel ferromagnetic plastic films which adhere to the wet surfaces of the internal organs: these materials (known as muco-adhesive polymers) will be configured primarily for pull retraction by magnetic probes but with other biomedical applications, e.g., surface marking of localised small lesions discovered during examinations with an endoscope; - design and development of novel technologies for magnetic grasping, as distinct from pull retraction, in conjunction with an adjustable magnetic force system which can be deployed either on the inner surface of the abdominal wall or outside the body. Multiple grasping devices, computer controlled from outside the body, can be used to handle the bowel as gently as possible to reduce the risk of injuryThese three strands constitute closely related components of an entirely novel system for magnetic retraction for the various MAS approaches. In the development of each strand extensive use will be made of a computer analysis technique known as finite element modeling, as well as experimentation in models of the relevant anatomy.The project requires the involvement of several different scientific disciplines: chemistry to create the polymer, physics to identify the desired characteristics of the ferromagnetic materials, engineering to create workable products from the scientific knowledge and surgery to direct the application of the entire enterprise.

Publications

10 25 50
 
Description The research carried out jointly between the University of Dundee (IMSaT) and the University of St Andrews (Chemistry - Dr Gordon Florence and Physics - Dr Pascal Andre) has produced a range of hybrid magnetic muco-adhesive polymers which adhere very strongly when applied to the serosal surface of bowel enabling retraction by magnetic probes with retraction forces up to 8 Newtons (measured by instron tensiometry experiments). Secondly, the research has lead to the design and development of a range of smart magnetic instruments and probes for atraumatic retraction of bowel and solid organs following application of magnetic muco-adhesive polymer films, with the ability for disengagement of the magnetically retracted tissues when needed during the intervention. Allied research carried out by the project has lead to the development of technology which detects slip, when tissue is grasped. The polymers can be magnetized by incorpration of either stainless steel microparticles or dextran coated iron oxide nanoparticles.
Exploitation Route Healthcare and Medical Technologies for minimal access surgery and interventional flexible endoscopy. The technology is being exploited through an existing collaborative agreement between the University of Dundee and Karl Storz UK following protection of IP by three patent applications.
Sectors Agriculture, Food and Drink,Education,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

 
Description Yes. The findings have been presented at several important international meetings for surgeons and biomedical engineering and medical physics. The findings have been published in over 20 peer-review journals and conference proceedings. There are 4 patent application published. And there are further three patent applications under filing and they have already been licensed to Karl Storz (UK, Germany) for further product development and clinical use.
First Year Of Impact 2013
Sector Education,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology
Impact Types Cultural,Societal,Economic

 
Description 3D Bioprinting 
Organisation Sichuan University
Country China 
Sector Academic/University 
PI Contribution The Nano-biotechnology a IMSaT and PIs from the Schools of Medicine and Life Scientists will collaborate the the development of this emerging technology through joint PhD programs and visits by senior staff from both Schools to the tissue engineering labs of Sichuan University and Revotek company which is across the road form the University.
Collaborator Contribution Reciprocal visits by PIs and PhD students from Sichuan University.
Impact Not yet
Start Year 2016
 
Title APPARATUS AND METHOD FOR THE DETECTION OF CELLS 
Description An apparatus and method for in-vivo detection of magnetically labelled biological molecules or cells, located in a flowing medium in a human or animal body such as the blood stream (13). The apparatus provides a magnetic field to a region of interest inside the body in order to attract the magnetically labelled biological molecules or cells (15) to the region of interest. A second magnetic field provides a variable magnetic field to the region of interest and which transfers energy to the magnetically labelled biological molecules or cells. A detector detects changes in the electromagnetic energy emitted by the labelled cells in response to the variable magnetic field generated by the second magnetic field source and provides a quantitative or qualitative measure of the magnetically labelled biological molecules or cells. The energy detected may be infra-red energy. 
IP Reference WO2010052471 
Protection Patent application published
Year Protection Granted 2010
Licensed No
Impact N/A
 
Title MAGNETIC RESONANCE IMAGING OF LABELLED CELLS 
Description A method and apparatus for obtaining a magnetic resonance image of a sample by applying a radio frequency signal to a sample containing magnetically labelled cells or tissues in order to heat the magnetically labelled cells or tissues and applying a sequence of radio frequency pulses to the sample to obtain magnetic resonance signals from the sample. Heating the magnetically labelled cells or tissues causes them to function as positive contrast agents providing positive image contrast in an image generated from the magnetic resonance signals. 
IP Reference EP2359157 
Protection Patent application published
Year Protection Granted 2011
Licensed No
Impact AB - A method and apparatus for obtaining a magnetic resonance image of a sample by applying a radio frequency signal to a sample containing magnetically labelled cells or tissues in order to heat the magnetically labelled cells or tissues and applying a sequence of radio frequency pulses to the sample to obtain magnetic resonance signals from the sample. Heating the magnetically labelled cells or tissues causes them to function as positive contrast agents providing positive image contrast in an image generated from the magnetic resonance signals.
 
Title MAGNETIC RESONANCE IMAGING OF LABELLED CELLS 
Description A method and apparatus for obtaining a magnetic resonance image of a sample by applying a radio frequency signal to a sample containing magnetically labelled cells or tissues in order to heat the magnetically labelled cells or tissues and applying a sequence of radio frequency pulses to the sample to obtain magnetic resonance signals from the sample. Heating the magnetically labelled cells or tissues causes them to function as positive contrast agents providing positive image contrast in an image generated from the magnetic resonance signals. 
IP Reference WO2010052474 
Protection Patent application published
Year Protection Granted 2010
Licensed No
Impact N/A
 
Title Medical instrument for manipulating, in particular retracting tissue or an organ. 
Description Patent by Cuschieri A. (2010) EP1797823B1 - Publication date: Mar 3, 2010 
IP Reference EP1797823 
Protection Patent application published
Year Protection Granted 2010
Licensed Yes
Impact Magnetic tissue retraction
 
Title Medical instrument for manipulating, in particular retracting tissue or an organ. 
Description Patent by Cuschieri, A. (2012) US8333695B2 - Publication date: Dec 18, 2012 
IP Reference US20070135685 
Protection Patent application published
Year Protection Granted 2012
Licensed Yes
Impact Magnetic tissue retraction