HEXITEC: Translation grant. The application of colour X-ray imaging

Lead Research Organisation: University of Manchester
Department Name: Materials

Abstract

X-ray colour imaging has the potential to visualise the physical and chemical nature of a specimen spatially resolved within a three dimensional density contrast image. X-ray colour imaging makes it possible to recognise, for example, whether complex manufactured components used in the aerospace industry are likely to fail through cracks or fatigue stress; or whether a suitcase contains illicit substances such as semtex or cocaine; or whether a biopsy sample contains normal or abnormal tissue. A full X-ray colour imaging system requires energy sensitive detectors that are divided into small discrete pixels and can stop high energy X-rays. In addition the scattered radiation from the sample often has to be very finely collimated because we are looking for very weak signals. Five years ago neither suitable detector material nor scatter control systems were available. The latter problem was addressed (by another EPSRC grant) but there was no reliable source of detector material anywhere in the world. The lack of technological expertise within the UK to produce suitable detector systems led to the formation of the HEXITEC consortium (High Energy X-ray Imaging Technology; www.hexitec.co.uk). HEXITEC has developed every stage of detector system manufacture and has very recently demonstrated its first 20 by 20 pixel prototype as a forerunner of a full 80 by 80 device that will be delivered early in 2010. We are now requesting funds to take the HEXITEC developed technology to the next stage of development in three work programmes covering four broad applications at different stages of development. Work package 1: Fluorescence tomography for materials imaging We will use the 80 by 80 pixel detector systems developed by HEXITEC for both purposes. Fluorescence tomography is based on a standard absorptive method where the sample is rotated in the beam and many sections are mathematically recombined to give a 3D image. The crucial difference here is that we will be able to do this in discreet energy ranges. We will obtain slices that can be energy selected in 800eV ranges or better. We will deliver a lab based system to produce element specific images. Work package 2: The appliaction of TEDDI to materails identificatication and security scanningThe TEDDI method uses scattered (not directly transmitted) X-rays which contain information on the crystal structure at each point within the sample. TEDDI uses multiple parallel collimators to obtain its spatial resolution and the sample does not need to be rotated in the same way as standard tomography. We will make a lab based TEDDI system to identify specific materials at each part of a complex sample on a 1x10-3 mm3 spatial scale. We will also work with our partners Kromek ltd who originally spun out of the Durham University Physics Department. They are developing scanners for threat identification at airports. We will jointly develop the TEDDI technology with HEXITEC detectors to recognise materials based on their coherent scattered signals. This is a much more reliable test than relying on purely absorptive information. In conjunction with existing methods the false alarm rate can be significantly reduced. Work package 3: Tissue BiopsyMany soft tissue types have very similar diffraction patterns especially those with a high water content, however certain types of breast cancers have been shown to be quite easily distinguishable from normal tissue by energy dispersive diffraction methods. We intend to develop, jointly with the Royal Surry and Marsden hospitals, an X-ray tissue biopsy modality. By using HEXITEC detector systems we will obtain unique information about specific tissue types that will significantly reduce the number of false positives. This is a vital aim because a false diagnosis leads to great deal of unnecessary discomfort and distress to the patient.

Planned Impact

X-ray tomography systems are widely used in hospitals, airports and engineering environments to provide three dimensional images for diagnosis, substance identification or to check the structural integrity of complex fabricated components. These tomographic images are formed by measuring transmitted X-rays at a variety of angles through the sample and mathematically reconstructing slices to render a full three dimensional density contrast image. However the structural information that is carried by the coherently scattered wavelengths (or colours) of X-rays is not utilised. This information is potentially very useful and can be used to identify materials located within a specific gauge volume (~10-3 mm3) of a much larger object. The scattered information is energy dispersed and contains crystallographic information such as lattice parameters (+ or - 0.005+), atomic positions (+ or - 0.08+) and degree of crystallinity (preferred orientation). This information can be used to identify the substance within the sampled gauge volume either analytically or by pattern recognition. The potential impact of this substance recognition capability is huge and has been recognised in the national press as outlined in the full impact plan. The main impact of this grant will be felt in three areas: Fluorescence tomography and Topographic Energy dispersive diffraction imaging: HEXITEC technology will allow fast analysis of structure and strain distributions as well as chemical contamination profiles within complex fabricated components. This will be especially useful for the evaluation of fail safe components used for aerospace applications. The impact here will be deliver an imaging modality that is not currently available anywhere in the world. Security scanners: HEXITEC technology will facilitate much faster and more reliable identification of explosive materials and recognise the signatures of other illicit substances. The number of false alarms can be significantly reduced by using optimised TEDDI systems in conjunction with existing security X-ray scanners. Tissue biopsy: HEXITEC technology will bring significant benefits to this area allowing identification of cancerous tissue which will optimise surgical procedures and steer post-operative radiological treatment. The number of false positives will drop saving patients from unnecessary, expensive and painful treatment. The general impact of the HEXITEC technology platform is even wider it is not possible to cover every aspect of that potential in one application. For example in oil and gas exploration one of the principal survey requirements is for real time analysis of core samples. Rapid identification of mineral and rock species will save rig time and deliver data for geo-steering and formation evaluation. Pharma companies have a continuing interest in the crystallisation of polymorphic forms as they critically affect the bioavailability of product. In the worst cases they can have a deleterious effect on the health of the patient. TEDDI methods can be used to study in-situ crystallisation as a function of growth parameters. This analysis is equally applicable to other applications in chemical engineering to study reactions deep within hidden recesses of stainless steel plant.

Publications

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Abdelkader MH (2012) Development and characterization of a laboratory based X-ray diffraction imaging system for material and tissue characterization. in Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

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Alkhateeb SM (2012) Breast tissue contrast-simulating materials using energy-dispersive X-ray diffraction. in Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

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Allwork C (2012) X-Ray Beam Studies of Charge Sharing in Small Pixel, Spectroscopic, CdZnTe Detectors in IEEE Transactions on Nuclear Science

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Alruhaili A (2014) Performance characteristics of CdTe drift ring detector in Journal of Instrumentation

 
Description On the HEXITEC translation grant we have discovered the following:
• We can reconstruct diffraction data to form real CT 3D images that contain crystallographic/structure information at each point
• This imaging can be carried out in the laboratory, not just on synchrotrons
• We can image amorphous materials using PDF reconstruction a well as 'standard' diffraction
• We can use bright field and dark field cases to provide 3D images, this means we can operate the system quite rapidly
• We can distinguish individual atomic elements in the CT image
• We can identify pathological and healthy tissues
• We can identify contraband in containers
• We can trace radioactive materials
• We can use very fast PCA methods to extract essential components from an object such as a specific element.
Exploitation Route There are alraedy sales of detectors via STFC and quantum detectors Ltd

Specrtal-X ltd has been spun out of UoM to design systems for security and medical biospy imaging. These are at earlky stages of development
Sectors Aerospace, Defence and Marine,Agriculture, Food and Drink,Chemicals,Construction,Electronics,Energy,Environment,Healthcare,Pharmaceuticals and Medical Biotechnology,Security and Diplomacy,Transport

URL https://en.wikipedia.org/wiki/High_energy_X-ray_imaging_technology
 
Description To design and build the HEXITEC detector which is currently being licensed to Quantum detectors Ltd Spectral-X Ltd has contacted a number of major European security system manufactures and is designing next generation security systems with integrated chemical sensitivity for explosives detection A number of HEXITEC research staff now work for Redlen technologies who are planning to build energy sensitive spectroscopy grade CZT detectors.
First Year Of Impact 2010
Sector Aerospace, Defence and Marine,Energy,Environment,Healthcare,Security and Diplomacy,Transport
Impact Types Societal,Economic

 
Description Leverhulme Research Grant
Amount £247,737 (GBP)
Funding ID RGP-2014-123 
Organisation The Leverhulme Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2014 
End 08/2017
 
Title A dispersive diffraction projection imaging system 
Description A very rapid dispersive diffraction pinhole imaging system for tomographic 3D imaging using diffraction patterns 
IP Reference WO2014045045 
Protection Patent application published
Year Protection Granted 2014
Licensed Commercial In Confidence
Impact This will revolutionize tomography giving the ability to regognise sample and tissue types
 
Title HEXTITEC detector 
Description The STFC Particle Physics Department New Detector Initiatives group brings together specialists in a cross-disciplinary group to investigate the Knowledge Exchange and Intellectual Property opportunities for our world-leading technology, to address the grand challenges of the STFC Futures programme, and to provide the skills and facilities needed to create the international projects of the future. In this case the HECTIC technology is being employed for astronomy. 
Type Of Technology Detection Devices 
Year Produced 2018 
Impact Too soon to say 
URL https://www.ppd.stfc.ac.uk/Pages/New-Detector-Initiatives.aspx
 
Company Name Spectral-X Ltd. 
Description The company has developed X-ray imaging technology for security, medical and non-destructive testing application. 
Year Established 2014 
Impact Currently making strategic partnership to develop colour X-ray imaging Patent pending on technology
Website http://www.192.com/atoz/business/wirral-ch47/sc/spectral-x-ltd/967bb975284637fa2c85bcdd110b56b6c4597...
 
Description Article in Photonics 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Increased awareness

Not mesured
Year(s) Of Engagement Activity 2013
URL http://www.photonics.com/Article.aspx?AID=52725
 
Description Press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact Increased interest

Eight ebquiries from companies interested in exploiting the technology
Year(s) Of Engagement Activity 2013
URL http://www.manchester.ac.uk/discover/news/article/?id=9317
 
Description Public lecture Liverpool 08 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Lively interest from the audience

School visits, two undergrads resulted
Several newspaper articles
Year(s) Of Engagement Activity 2008
 
Description The Engineer web site 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Incresed awareness in engineering

Not measured
Year(s) Of Engagement Activity 2013
URL http://www.theengineer.co.uk/more-sectors/electronics/news/camera-takes-3d-colour-x-ray-photographs-...