BeatBox - HPC Environment for Biophysically and Anatomically Realistic Cardiac Simulations
Lead Research Organisation:
University of Manchester
Department Name: Physics and Astronomy
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
People |
ORCID iD |
| Henggui Zhang (Principal Investigator) |
Publications
Adeniran I
(2011)
Increased vulnerability of human ventricle to re-entrant excitation in hERG-linked variant 1 short QT syndrome.
in PLoS computational biology
Adeniran I
(2017)
In silico investigation of a KCNQ1 mutation associated with short QT syndrome.
in Scientific reports
Adeniran I
(2013)
In silico investigation of the short QT syndrome, using human ventricle models incorporating electromechanical coupling.
in Frontiers in physiology
Alday EA
(2015)
A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems--insights from 3D virtual human atria and torso.
in PLoS computational biology
Alghamdi AM
(2020)
Mechanistic Insights Into the Reduced Pacemaking Rate of the Rabbit Sinoatrial Node During Postnatal Development: A Simulation Study.
in Frontiers in physiology
Alghamdi AM
(2020)
Cardiac Pacemaker Dysfunction Arising From Different Studies of Ion Channel Remodeling in the Aging Rat Heart.
in Frontiers in physiology
Alrabghi G
(2023)
Human atrial fibrillation and genetic defects in transient outward currents: mechanistic insights from multi-scale computational models.
in Philosophical transactions of the Royal Society of London. Series B, Biological sciences
| Description | Key findings: - Beatbox has been transferred from an in-house tool into a publicly available software distributed freely under GNU license, with auto-configuration infrastructure to be easily adaptable for new architecture, detailed user manual, automatic tests, and example scripts illustrating its use. - New technical features have been incorporated into the software: new solvers (multigrid elliptic solver for the bidomain model, alternating-direction timestepper for the diffusion); several new local kinetics/cardiac excitation kinetics models, both from CELLML and implemented from scratch or based on author code; examples of new anatomical models (human atrium, rabbit heart), including those that originate from MRI datasets, and new output and postprocessing facilities. - A workshop for the current and prospective users of Beatbox has been held, with presentations explaining principles and software solutions befhind it, as well as hands-in tutorials. - The software has been used in ongoing research which resulted in a number of journal publications and conference presentations. Some of the research results would be difficult or impossible to obtain with other existing software, for instance, arrythmogenic effect of nontrivial spatio-temporal changes of cardiac tissue properties (reperfusion arrhythmias) and complex behaviour of scroll waves in realistic atrial geomery subject to feedback-controlled low-voltage stimulation. |
| Exploitation Route | The software is usable by pharmaceutical and biomedical industries, for "in silico" say for testing of new drugs or ICDs. It is also usable for education purposes, say by students of electrophysiology, both within and outside academia. Finally, some of the programming solutions are usable in software technology. The software is distributed freely under GNU license through author's website. The research results are disseminated in the usual way, through open publications, conference presentations and personal contacts of the authors. |
| Sectors | Education |
| URL | http://empslocal.ex.ac.uk/people/staff/vnb262/projects/BeatBox/ |