EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation

Lead Research Organisation: University of Strathclyde
Department Name: Inst of Pharmacy and Biomedical Sci

Abstract

This proposal will establish a national multidisciplinary centre for research into crystals and powders and the challenges presented by their industrial manufacture, properties and use. Powders, particles, crystals and the molecules they are made of are important in the chemical and pharmaceutical industries as intermediate stages and final products in the manufacture of a range of materials from drugs to inks and pigments to paints to computer screens. Crucially, the structure and properties of crystals, particles and powders control the ease of manufacture, function and performance of the final product and it is therefore important to be able to make these materials reproducibly. Firstly, by understanding the ways in which the molecules, which make up the crystal pack together. Many molecules can adopt several distinct crystal forms by packing together in different ways, which can dramatically affect physical properties despite the fact the same molecule is present. It is vital to control this during crystal formation since the wrong form could for example, affect the amount of drug released by a tablet into the body after it is swallowed. Secondly as the crystal grows its size (micrometres or millimetres), shape, or morphology (flat or round) is critical for some applications especially when many crystal particles come together in a powder and impact on the ease with which the material is subsequently manufactured into a paint or ink for example. These challenges are critical as currently manufacturers struggle with crystal formation and control of their particle and powder properties due to the traditional batch methods they employ. To tackle these problems the Centre aims to revolutionise current processes by researching exciting new continuous methods of crystal formation and particle and powder production applicable to current but importantly also future products such as nanomaterials. In addition the Centre will explore how established methods for molecule synthesis are best integrated with continuous crystallisation processes and how continuously manufactured crystals are isolated, dried and transferred into subsequent formulation and final product manufacturing stages whilst preserving their carefully optimised properties. To maximize these technology changes the Centre must also understand the impact that such a transformation will have on the way companies approach this aspect of their business. This will ensure that the maximum economic potential is effectively exploited. To achieve this the Centre consists of a multidisciplinary team of 14 outstanding researchers from 7 leading Universities covering the country from Glasgow, to Edinburgh, to Cambridge, to Bath. In addition industrial support, interest and input (2 million) will be provided from 3 major pharmaceutical companies and many small technology driven companies within the UK. This provides a combination of academic and industrial expertise ranging from chemistry and chemical engineering to pharmacy and systems management capable of powerfully attacking the issues from many angles. The Centre's aim is to deliver new continuous manufacturing technologies with improved performance in a range of areas. Control of crystal formation and particle and powder properties is critical, however a key goal will also be the development of simpler and faster technologies. Such a combination will permit quicker product development and cheaper, cleaner and greener manufacturing processes. The Centre will deliver these technologies to the UK chemical and pharmaceutical industry thus maintaining this sector at the international forefront of product development and manufacture with obvious national economic benefits in terms of jobs and income. National and international benefits will also arise through better and new medicines and improved and new consumer products, which will assist the global community.

Planned Impact

Many products in modern-day life utilise chemicals in the form of crystalline solids whose manufacture typically involves several discrete batch processes to achieve the final desired product function, form and cost. This Centre in Innovative Manufacturing (CIM) will deliver the manufacturing research required to shift approximately 60-80% of current batch manufacturing processes to a continuous basis providing a substantial competetive advantage to UK manufacturing through reduced costs and enhanced high value products. The benefits to industry and the UK economic well-being will be realised through new and emerging technology for: fundamental process understanding of continuous crystallisation for the manufacture of chemical solids; continuous processing methods and equipment for handling of chemical solids for optimised manufacturing; analysis and real-time process control. Together this will produce better performing, more reproducible and controlled manufacturing processes, supply chains, systems and platform technologies. Scientists and engineers involved in crystallisation and the production of many types of chemicals in solid form will benefit from the manufacturing research that emerges from this Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation. The ability to impart better control over the fundamental processes that govern particle structure and properties, will not only yield improved quality materials, but also new opportunities to mass produce novel materials that cannot be made reliably using traditional methods. Also, industrialists concerned with manufacturing processes that rely on batch approaches, for example pharmaceuticals, or other sectors such as foods, cosmetics or energetic materials will benefit through better control over particle formation through the platform technologies and process understanding generated. Whilst we have a strong initial focus on the manufacturing of pharmaceuticals, the manufacturing research enabled by this CIM has the potential to create new opportunities in other materials and materials systems where particle size/form control in crystallization is critical. Thus the CIM has the long-term potential to contribute to developing new electronically interesting materials, dyes, quantum dots leading to new industrial applications in displays, electronics, sensors, solar cells and inks, for example. In addition to supporting the needs of the end users, the CIM will support the development and commercialization of new technologies that will enable the new manufacturing paradigms to be implemented. This will stretch beyond chemical sciences into other areas such as sensors and measurement devices, modelling and prediction. The Centre will provide a fertile environment for such new technologies to be rapidly tested on industrially relevant projects and activities, and success in this environment will facilitate faster commercialization at a larger scale. This will help enhance the UK position, not just as an inventor, but also as an innovator through successful commercialization.

Publications

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publication icon
Alexander AJ (2019) Non-photochemical laser-induced nucleation. in The Journal of chemical physics

 
Title Future impact in patient medicines 
Description Future impact in patient medicines: Images of Research University of Strathclyde 2014 Laura Martinez Marcos Industrial manufacturing of medicines is currently undergoing key changes that will lead to better medicines as well as meeting patient requirements. As one of the main steps involved, powder processing will become pivotal within the Pharmaceutical Industry. From a mixture of solid powders to a complete change in shape and material state due to the application of high temperatures and pressure. This is the outcome provided by novel manufacturing technologies. Commended Entry - Business and Industry Section 
Type Of Art Image 
Year Produced 2014 
Impact The Images of Research collection tours venues in the West of Scotland following their launch during the Engage with Strathclyde week of events. It is possible to View the 2014 images in the online gallery. 
URL http://www.imagesofresearch.strath.ac.uk/2014/gallery.php
 
Title Hidden Door Festival Installation 
Description 8 Month residency with CMAC by artist Fiona McGurk who produced a multidisciplinary installation of visual artworks inspired by the TIC build project and observations of continuous manufacturing research and data collection. The installation was showcased at Hidden Door Festival, Edinburgh 28th - March - 5th April 2014. 
Type Of Art Artwork 
Year Produced 2014 
Impact Over 7500 visitors viewed the work which gained national press reviews. 
 
Title Industrial Dilemmas 
Description Images of Research University of Strathclyde 2014 Industrial Dilemmas Naomi Briggs and Fiona McGurk Bearding, Fouling, Scaling, Sticking, Encrustation - the formation of solid crust during pharmaceutical crystallisation. This is one of the major limiting factors preventing the successful implementation of industrial continuous crystallisation. It leads to uncontrolled processing, blockages and all sorts of predicaments. Continuous crystallisation provides higher quality medicines, cheaply, with a reduced footprint. Careful control will accelerate the adaption of continuous crystallisation Commended Entry - Business and Industry Section 
Type Of Art Image 
Year Produced 2014 
Impact The Images of Research collection tours venues in the West of Scotland following their launch during the Engage with Strathclyde week of events. It is possible to View the 2014 images in the online gallery. 
URL http://www.imagesofresearch.strath.ac.uk/2014/gallery.php
 
Title The onset of crystallisation? 
Description Images of Research University of Strathclyde 2014 The onset of crystallisation? Thomas McGlone Many pharmaceutical products feature a crystallisation stage in their production. Crystallisation is the spontaneous formation of millions of tiny particles containing a highly organised array of molecules packed together with specific orientations. The way these molecules pack can drastically affect the performance of the final product. This picture highlights macroscopically the birth of the crystal particles in a special type of reactor, with swirling flow, to allow a greater level of control. Commended Entry - Academia section 
Type Of Art Image 
Year Produced 2014 
Impact The Images of Research collection tours venues in the West of Scotland following their launch during the Engage with Strathclyde week of events. It is possible to View the 2014 images in the online gallery. 
URL http://www.imagesofresearch.strath.ac.uk/2014/gallery.php
 
Description Key Findings
CMAC have published over 140 peer reviewed scientific journal articles as a result of research efforts since October 20011. Additionally, 8 white Papers from the joint CMAC-MIT International Symposium on Continuous Manufacturing of Pharmaceuticals were published to inform the global academic, industrial and regulatory community of experts. Contributions to the UK Manufacturing Review, Dowling Review, TSB Future of BioPharmaceutical High Value Manufacturing Deep Dive, MMIP landscape mapping and Medicines Manufacturing Innovation Centre proposition development have influenced the national and international wider agenda in the future of advanced manufacturing. Book chapters, technical application notes, press and online articles have also been published. All these outputs are listed in the common outcomes section and key titles are summarised below.

Years 1-2: Phase I
Phase I of CMAC CIM research plan mainly concentrated on areas of continuous crystallisation and supply chain management as per the flagship research projects highlighted in the original Centre bid. Themes were: continuous manufacturing of solid particles; and manufacturing operations and supply chain management challenges.
Years 3-5: Phase II
Research carried out was focussed on building on the progress made in Phase I to deliver an ambitious co-ordinated programme of research that would transform capabilities for continuous manufacturing of high value chemicals and in particular, pharmaceuticals. The direction of Phase II drew on the technical targets and industry problems statements collated by the Centre's industry technical committee and by extensive discussion across the academic team. There were three themes:
• Laboratory-scale continuous process capabilities to support end-to end manufacturing;
• tools and workflows for rapid product assessment, and
• continuous process selection and product-process archetypes that support supply chains of the future.

Key outputs during 2011-2016:
Workflow Development
Phase II of the Centre research programme has focussed on developing a seeded cooling crystallisation workflow as a core activity upon which others can build. This workflow has been demonstrated for several model compounds including Paracetamol, Lovastatin and Fenofibrate with further publications in draft for submission over coming months. The seeded cooling crystallisation worflow provides a basis for further processes to integrate with crystallisation up and downstream and can also be adapted and updated for alternative types of crystallisation processes. Work on developing workflows for other crystallisation types including anti-solvent, reactive and salt formation processes is ongoing. Ultimately we plan to map types of API particle to archetypical product processes.
Dissemination:
C. J. Brown et al, (2017) Enabling precision manufacturing of active pharmaceutical ingredients: Workflow for seeded cooling continuous crystallisation, in preparation.
Jawor-Baczynska, Anna, Moore, Barry D., & Sefcik, Jan. (2015). Effect of mixing, concentration and temperature on the formation of mesostructured solutions and their role in the nucleation of dl-valine crystals. Faraday Discussions, 179(0), 141-154. doi: 10.1039/C4FD00262H
McGinty, J., Price, C., & Sefcik, J. (2016, November). Continuous Reactive Crystallisation for Control of Salt Formation Processes. Presented at the AIChE 2016 annual meeting, San Francisco, USA.
H.Siddique et al, (2017) title, in preparation
Svoboda, Vaclav, MacFhionnghaile, Pól, McGinty, John, Connor, Lauren E., Oswald, Iain D. H., & Sefcik, Jan. (2017). Continuous co-crystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation: Exploring opportunities between reactive and antisolvent crystallization concepts. Crystal Growth & Design. doi: 10.1021/acs.cgd.6b01866

Platform Development
During 2011-2016 the Centre actively developed several existing technology platforms at the University of Strathclyde, Loughborough, Heriot-Watt and Bath, including the mixed suspension mixer product removal (MSMPR) crystalliser, continuous stirred tank reactors (CSTRs), the meso-scale and full scale continuous oscillatory baffled crystalliser (COBC) (See pages 90-92 for full details). We also have the custom made reconfigurable integrated modular crystallisation miniplant (Microinnova) that is housed in the CMAC Facility. A patent was filed for a device for inducing nucleation at Heriot-Watt University. Other work included bespoke nucleation units to obtain suitable seed suspension at the University of Strathclyde, establishing parameters necessary as a precursor for continuous crystallisation on MF-OBC and the design of a new flow crystallisation technology for the development of multicomponent agrochemicals at the University of Bath.

Key papers:
Briggs, Naomi E. B., Schacht, Ulrich, Raval, Vishal, McGlone, Thomas, Sefcik, Jan, & Florence, Alastair J. (2015). Seeded Crystallization of ß-l-Glutamic Acid in a Continuous Oscillatory Baffled Crystallizer. Organic Process Research & Development, 19(12), 1903-1911. doi: 10.1021/acs.oprd.5b00206
Ejim, Louisa N., Yerdelen, Stephanie, McGlone, Thomas, Onyemelukwe, Iyke, Johnston, Blair, Florence, Alastair J., & Reis, Nuno M. (2017). A factorial approach to understanding the effect of inner geometry of baffled meso-scale tubes on solids suspension and axial dispersion in continuous, oscillatory liquid-solid plug flows. Chemical Engineering Journal, 308, 669-682. doi: http://dx.doi.org/10.1016/j.cej.2016.09.013
Martinez-Marcos, Laura, Lamprou, Dimitrios A., McBurney, Roy T., & Halbert, Gavin W. (2016). A novel hot-melt extrusion formulation of albendazole for increasing dissolution properties. International Journal of Pharmaceutics, 499(1-2), 175-185. doi: http://dx.doi.org/10.1016/j.ijpharm.2016.01.006
McGlone, Thomas, Briggs, Naomi EB, Clark, Catriona A, Brown, Cameron J, Sefcik, Jan, & Florence, Alastair J. (2015). Oscillatory flow reactors (OFRs) for continuous manufacturing and crystallization. Organic Process Research & Development, 19(9), 1186-1202.
Powell, K. A., Saleemi, A. N., Rielly, C. D., & Nagy, Z. K. (2015). Periodic steady-state flow crystallization of a pharmaceutical drug using MSMPR operation. Chemical Engineering and Processing: Process Intensification(0). doi: http://dx.doi.org/10.1016/j.cep.2015.01.002
Robertson, Karen, Flandrin, Pierre-Baptiste, Klapwijk, Anneke R., & Wilson, Chick C. (2016). Design and Evaluation of a Mesoscale Segmented Flow Reactor (KRAIC). Crystal Growth & Design, 16(8), 4759-4764. doi: 10.1021/acs.cgd.6b00885
Sayin, R., Martinez-Marcos, L., Osorio, J. G., Cruise, P., Jones, I., Halbert, G. W., . . . Litster, J. D. (2015). Investigation of an 11mm diameter twin screw granulator: Screw element performance and in-line monitoring via image analysis. Int J Pharm. doi: 10.1016/j.ijpharm.2015.09.024

Supply Chain Management
This research explores future value network configurations which may enable novel routes to medicines production, and the delivery of added value to 'end-users', i.e. payers and patients. We are using case studies to assess end-to-end (E2E) benefits and emerging patterns in a variety of contexts. The business case for transformation from batch to continuous processing can be assessed using the techniques developed through this research. The current state has been mapped for model compounds and the future state will be explored through the Future CMAC Hub programme and Remedies projects.

Alinaghian, L.; Ates, A.; Bititci, U.; Harrington, T.; Srai, J. S.; Talati, R. (2012). Drivers and barriers of continuous manufacturing in the pharmaceutical industry. In 16th Cambridge International Manufacturing Symposium: Cambridge, 2012.
Harrington, T. S., & Srai, J. S. . (2016). Understanding stages of supply network emergence in technology commercialisation. International Journal of Manufacturing Technology and Management. doi: 10.1504/IJMTM.2016.10000001
Harrington, T. S., Kirkwood, D.A. & Srai, J. S. (2012). Performance Metric Selection Methodology for Multi- Organizational Service Network Integration. The Journal of Applied Management and Entrepreneurship, 17(3), 30-35.
Harrington, T. S.; Alinaghian, L.; Srai, J. S. (2013a). "Continuous Manufacturing and Product-Process Archetypes: Implications for Supply Network Design in Pharma". In 24th Annual Production and Operations Management Society (POMS) Conference: Denver, 2013.
Harrington, T. S.; Alinaghian, L.; Srai, J. S. (2013b). " Exploring Implications of Continuous Manufacturing within the Pharmaceutical Sector through Industrial Landscape Mapping and Cross-Sector Analysis". In Industry Studies Association (ISA) Conference: Kansas City, 2013.
Harrington, Tomás S., Phillips, Mark A., & Srai, Jagjit Singh. (2016). Reconfiguring global pharmaceutical value networks through targeted technology interventions. International Journal of Production Research, 1-17. doi: 10.1080/00207543.2016.1221541
Srai, J. S., Alinaghian, L. S., & Kirkwood, D. A. (2013). Understanding sustainable supply network capabilities of multinationals: A capability maturity model approach. Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture, 227(4), 595-615. doi: 10.1177/0954405412470597
Srai, J. S., Harrington, T.S., Alinaghian, L. (2014). An approach to exploring integration benefits of continuous flow technologies within Pharmaceutical supply chains. Chemistry Today, 32(SUPPLEMENT - CROS CMOS), P. 27-34.
Srai, Jagjit Singh, & Alinaghian, Leila Sadat. (2013). Value Chain Reconfiguration in Highly Disaggregated Industrial Systems: Examining the Emergence of Health Care Diagnostics. Global Strategy Journal, 3(1), 88-108. doi: 10.1111/j.2042-5805.2012.01047.x
Srai, Jagjit Singh, Harrington, Tomás, Alinaghian, Leila, & Phillips, Mark. (2015). Evaluating the potential for the continuous processing of pharmaceutical products-a supply network perspective. Chemical Engineering and Processing: Process Intensification, 97, 248-258. doi: http://dx.doi.org/10.1016/j.cep.2015.07.018
Srai, Jagjit Singh, Mukesh Kumar, Gary Graham, Wendy Phillips, James Tooze, Simon Ford, Paul Beecher, Baldev Raj, Mike Gregory, Manoj Kumar Tiwari, B. Ravi, Andy Neely, Ravi Shankar, Fiona Charnley & Ashutosh Tiwari. (2016). Distributed Manufacturing: scope, challenges and opportunities. Int. J. Production Research, 54(23), 6917-6935.
Srai, Tomás Seosamh Harrington; Jagjit Singh. (2012). Defining product-service network configurations and location roles: a current and future state analysis framework for international engineering operations. International Journal of Product Development (IJPD), 17(3/4), 228-253. doi: 10.1504/IJPD.2012.052103


First Continuous Extended Run
CMAC successfully ran a 5 day continuous crystallisation of lactose experiment using the Cambridge Reactor Design Rattlesnake oscillatory flow reactor in Early 2014. The Continuous crystallisation campaign was successfully performed at a throughput of 300-500 g/hr of desired alpha-lactose for 96 hours without any fouling or blockage. The system reached steady state after one and half residence times. Mean particle size was readily tuned during the camping by varying the operating conditions to deliver desired particles. Consistent crystal habit was obtained throughout the process and analysis using XRPD confirmed the product purity with no unwanted primary nucleation. This continuous process yielded 26% more material with increased product specification than could be obtained from an equivalent batch process

Siddique, Humera, Brown, Cameron J., Houson, Ian, & Florence, Alastair J. (2015). Establishment of a Continuous Sonocrystallization Process for Lactose in an Oscillatory Baffled Crystallizer. Organic Process Research & Development. doi: 10.1021/acs.oprd.5b00127

First Continuous Experiment in CMAC Facility
The first continuous experiment in the CMAC Facility took place in May 2015. A continuous seeded cooling crystallisation of Lactose was performed in the NiTech DN15 continuous oscillatory baffled crystalliser. Step tests were performed on seed flow rate to build predictive models for concentration control and were validated real-time. The system was run for three days to achieve "dial-a-particle" capability. This work was done in partnership with Perceptive Engineering.

National Centre Link with Other Major National Projects
2015 saw the kick-off of secondary manufacturing AMSCI projects, Remedies which has enabled a significant increase in research portfolio in the primary to secondary manufacturing area. CMAC are a partner in the AMSCI Digital Design Project, ADDoPT which launched 2Q 2015.

Paracetamol as an Exemplar
A body of work using paracetamol to exemplify our approach has been created. This will provide a foundation for the Future CMAC Hub "quick wins" project that will demonstrate integration of primary and secondary continuous processing in a laboratory scale microfactory by July 2017.
Key Dissemination:
Agnew, Lauren R., Cruickshank, Dyanne L., McGlone, Thomas, & Wilson, Chick C. (2016). Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment. Chemical Communications. doi: 10.1039/C6CC01032F
Brown, C.J.; et al, (2017) Enabling precision manufacturing of active pharmaceutical ingredients: Workflow for seeded cooling continuous crystallisation, in preparation.
Ottoboni, Sara, Chrubasik, Michael, Mir Bruce, Layla, Nguyen, Thai Thu Hien, Johnston, Blair, Florence, Alastair, & Price, Chris John. (2016, 2016/6/28). The impact of paracetamol impurities on face-specific properties. Paper presented at BACG 2016
Ottoboni, Sara, Price, Chris John, Steven C., Meehan E., Barton, A., Mitchell A. (2016) Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing: a case study using paracetamol" paper presented at FILTECH 2016
Powell, Keddon A., Saleemi, Ali N., Rielly, Chris D., & Nagy, Zoltan K. (2016). Monitoring Continuous Crystallization of Paracetamol in the Presence of an Additive Using an Integrated PAT Array and Multivariate Methods. Organic Process Research & Development. doi: 10.1021/acs.oprd.5b00373

Advanced Crystallisation is a key aspect of the CMAC body of work and is being addressed in collaboration with colleagues from CPOSS (EP/K039229/1) and Dr Iain Oswald, who has recently received an EPSRC Fellowship (EP/N015401/1).
Bhardwaj, Rajni M, Raval, Vishal, Oswald, Iain DH, & Florence, Alastair J. (2015). Crystal structure of a mixed solvated form of amoxapine acetate. Acta Crystallographica Section E: Crystallographic Communications, 71(2), 139-141.
Bhardwaj, Rajni M, Yang, Huaiyu, & Florence, Alastair J. (2016). Crystal structure of the co-crystal butylparaben-isonicotinamide (1/1). Acta Crystallographica Section E: Crystallographic Communications, 72(1), 53-55. doi: 07/S2056989015023518
Klapwijk, Anneke R., Simone, Elena, Nagy, Zoltan K., & Wilson, Chick C. (2016). Tuning crystal morphology of succinic acid using a polymer additive. Crystal Growth & Design. doi: 10.1021/acs.cgd.6b00465
McLachlan, Hannah, & Ni, Xiong-Wei. (2016). On the effect of added impurity on crystal purity of urea in an oscillatory baffled crystallizer and a stirred tank crystallizer. Journal of Crystal Growth, 442, 81-88. doi: http://dx.doi.org/10.1016/j.jcrysgro.2016.03.001
Srirambhatla, Vijay K., Guo, Rui, Price, Sarah L., & Florence, Alastair J. (2016). Isomorphous template induced crystallisation: a robust method for the targeted crystallisation of computationally predicted metastable polymorphs. Chemical Communications. doi: 10.1039/C6CC01710J
Wittering, K. E., Agnew, L. R., Klapwijk, A. R., Robertson, K., Cousen, A. J. P., Cruickshank, D. L., & Wilson, C. C. (2015). Crystallisation and physicochemical property characterisation of conformationally-locked co-crystals of fenamic acid derivatives. CrystEngComm, 17(19), 3610-3618. doi: 10.1039/C5CE00297D

We have made progress with our Informatics and Modelling research which will underpin the Future CMAC Hub programme in collaboration with colleagues in the ICT-CMAC (EP/K014250/1) and ADDoPT programmes.
Agimelen, Okpeafoh S., Hamilton, Peter, Haley, Ian, Nordon, Alison, Vasile, Massimiliano, Sefcik, Jan, & Mulholland, Anthony J. (2015). Estimation of particle size distribution and aspect ratio of non-spherical particles from chord length distribution. Chemical Engineering Science, 123, 629-640. doi: http://dx.doi.org/10.1016/j.ces.2014.11.014
Agimelen, Okpeafoh S., Jawor-Baczynska, Anna, McGinty, John, Dziewierz, Jerzy, Tachtatzis, Christos, Cleary, Alison, . . . Mulholland, Anthony J. (2016). Integration of in situ imaging and chord length distribution measurements for estimation of particle size and shape. Chemical Engineering Science, 144, 87-100. doi: http://dx.doi.org/10.1016/j.ces.2016.01.007
Agimelen, Okpeafoh S., Mulholland, Anthony J., & Sefcik, Jan. (2017). Modelling of artefacts in estimations of particle size of needle-like particles from laser diffraction measurements. Chemical Engineering Science, 158, 445-452. doi: http://dx.doi.org/10.1016/j.ces.2016.10.031
Bhardwaj, Rajni Miglani, Johnston, Andrea, Johnston, Blair, & Florence, Alastair James. (2015). A Random Forest Model for Predicting the Crystallisability of Organic Molecules. CrystEngComm. doi: 10.1039/c4ce02403f
Su, Qinglin, Benyahia, Brahim, Nagy, Zoltan K., & Rielly, Chris D. (2015). Mathematical Modeling, Design, and Optimization of a Multisegment Multiaddition Plug-Flow Crystallizer for Antisolvent Crystallizations. Organic Process Research & Development, 19(12), 1859-1870. doi: 10.1021/acs.oprd.5b00110
Su, Qinglin, Nagy, Zoltan K., & Rielly, Chris D. (2015). Pharmaceutical crystallisation processes from batch to continuous operation using MSMPR stages: Modelling, design, and control. Chemical Engineering and Processing: Process Intensification, 89(0), 41-53. doi: http://dx.doi.org/10.1016/j.cep.2015.01.001
Su, Qinglin, Rielly, Chris D., Powell, Keddon A., & Nagy, Zoltan K. (2016). Mathematical modelling and experimental validation of a novel periodic flow crystallization using MSMPR crystallizers. AIChE Journal, n/a-n/a. doi: 10.1002/aic.15510
Exploitation Route Industry Partner are using our research applied to their proprietary projects.
Sectors Agriculture, Food and Drink,Chemicals,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

URL https://www.cmac.ac.uk/CIM_Summary.htm
 
Description 1. Overview The EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation was established in October 2011 with a team that included three of the world's largest pharmaceutical companies (Astra Zeneca, GSK and Novartis) and seven leading UK research Universities (Bath, Cambridge, Edinburgh, Glasgow, Heriot Watt, Loughborough and Strathclyde). The joint long-term vision was to enable a step change from the current batch manufacturing paradigm to fully continuous manufacturing processes, systems and plants for the production of high-value chemical products to higher levels of quality, at a lower cost and in a more sustainable manner. In partnership, the academics, industrialists and the Research Council established a national EPSRC Centre for Innovative Manufacturing to enable industry to manufacture better particles and solid-state products and inform the future supply-chain for realising this new manufacturing paradigm. The collaborative national Centre team established by this award have collectively delivered a large scale programme attracting £100m in direct and in kind support from a range of funding sources including research councils, funding councils, industry, Innovate UK and charity. Our research outputs span new approaches and technologies for continuous crystallisation and understanding of nucleation and growth processes, novel process technologies, process analysis, control and design, particle performance in formulated products and analysis of medicine supply chains. The extensive programme has stimulated collaborative links with over 22 universities across the UK and EU, USA and Singapore to progress manufacturing research and training aligned with the goal of accelerating the adoption of continuous manufacturing. In addition to stimulating manufacturing research, an EPSRC funded Doctoral Training Centre, embedded within the Centre, plus a Scottish Funding Council supported M.Sc. course have contributed to establishing a talent pipeline for the future research and industry leaders in continuous manufacturing. Significant investments in UK infrastructure to support manufacturing research have been delivered in support of our vision. A £33.4m UK Research Partnership Investment fund award, plus EPSRC strategic equipment funding and Wolfson Foundation support have enabled the CIM to establish a unique national facility within the £100m Technology Innovation Centre at the University of Strathclyde. The open access, world class facilities for advanced pharmaceutical processing and product research have created a unique physical hub for multidisciplinary collaborative research. Critically, over the duration of the award, the Hub has established successful and effective mechanisms for industry engagement and pre-competitive collaboration. CMAC has established itself as the premier international crystallisation research centre. The number of Tier 1 industrial user partners, has grown from 3 to 7 over the 5 years of the Centre award. Additionally 16 technology and SME companies have joined as tier 2 partners, as well as a range of suppliers and collaborative companies. EPSRC Impact Accelerator Account (IAA) support (Strathclyde, Edinburgh, Loughborough) has also been used to augment the impact of centre research. As a national Centre, the team have developed a range of initiatives to engage with the wider academic and industry communities with interests in this area through funded feasibility projects and networking events. This has extended to influence the UK innovation landscape by contributing to the development of two major AMSCI projects, REMEDIES and ADDoPT. Looking ahead, CMAC has been working jointly with CPI Ltd of the HVM Catapult to develop a joint proposal for a new Medicines Manufacturing Innovation Centre . 2. Emerging economic and societal impact Growth of People and Investment The EPSRC Centre award of £6m started on 1st October 2011 and the Centre was launched with 13 academic investigators, eight RA's, eight PhD's (co-funded by EPSRC and the universities) and three management personnel. By the end of the grant (December 2016) CMAC has grown the community to include 14 academic investigators, 20 Research Associates (5 posts directly funded by CIM), 53 PhDs and 10 management and administrative personnel (3 directly funded by CIM). So far the talent pipeline has been a major success story: 60% of alumni from CMAC have gone into industry roles in the UK (e.g. GSK) and internationally (Eli Lilly, Mettler Toledo) with the remainder progressing in academic roles at institutions (MIT, Imperial College). Over 30 students have graduated from the new Advanced Pharmaceutical Manufacturing MSc programme. Additional aligned doctoral studentship programmes have been established with NPL (3 PhDs to date) in pharmaceutical manufacturing metrology and with Nanyang Technological University in Singapore (6 students to date) as part of a new collaborative international PhD programme. Staff numbers have grown during the grant period. This includes 11 new posts established by the University of Strathclyde to provide direct support to industry to access CMAC's unique manufacturing research capabilities, delivering £0.7M of projects in its first year. The creation of CMAC has also attracted an EPSRC Manufacturing fellow, Dr Chris Price, to join the University of Strathclyde from GSK. This has brought a leading industrial practitioner into the academic community to carry out ambitious new research targeted at advancing purification capabilities. CMAC has also provided support to stimulate and encourage other research projects notably EPSRC early career manufacturing fellowships for Dr Iain Oswald, University of Strathclyde and Dr Jerry Heng, Imperial College London. The original Centre business plan targeted growing the total programme from £6M to £32M over the five years of the award. By the mid term review in summer 2014, CMAC had more than doubled this with the total portfolio by the end of the award totalling ca. £100M of new activity. The investments include £5m EPSRC Doctoral Training Centre that includes over £0.5M industry support, a £33.4m UK RPIF partnership supporting major investment in equipment in the Centre and all the partners; £4M has also been invested by the University of Strathclyde in new specialist laboratory facilities in TIC to house all staff and researchers alongside the UK RPIF national facility. CMAC played a key role in developing a major £23m AMSCI supply chain project, REMEDIES led by GSK, that seeks to reconfigure the medicines end to end supply chain and a further support of £0.72M from SFC is supporting CMAC research in hot melt extrusion and additive manufacturing technologies associated with this. CMAC are also academic partners in the AMSCI ADDoPT programme contributing data seveloped from the CIM programme to advance new modelling techniques. Additional support has been secured by academic colleagues to lead he development of ICT intelligent decision support technologies through a £3.4m EPSRC ICT for manufacturing programme and £1.5m in joint TSB/EPSRC programmes. Critically, with the recent addition of the CMAC Future Manufacturing Research Hub, CMAC is creating a sustained contribution to the UK research and innovation system. Research CMAC has delivered a coordinated and high quality programme of research against the scope outlined in the bid (please refer to key findings section for further details on specific outputs). These outputs include a range of core aspects advancing our understanding and capabilities to design, control and implement crystallisation exploiting the advantages of continuous processing to achieve improved quality. A critical element of the collaborative research has been the development of dedicated systematic experimental workflows. These innovative methodologies enable a science based approach that pre-empts many issues encountered during industrial crystallisation development to achieve robust, consistent crystallisation delivery. Through the DTC funded electronic laboratory notebook implementation, systematic acquisition of data from across multiple development and process operation stages, has created new outputs from collaborative research aligned with machine learning tools for example. CMAC has developed an international collaborative academic and industry network. This has lead to major, high profile events, notably, in 2014 and 2016 CMAC co-hosted the first and second International Symposia on Continuous Manufacturing of Pharmaceuticals (ISCMP) at MIT, US. These prestigious events were attended by the world leaders in continuous processing and the regulators for this industry. The key outputs from the first symposium were eight white papers which have now been published in the Journal of Pharmaceutical Sciences, Volume 104 (March 2015) Special Topic Commentaries on Continuous Manufacturing. One of the major outputs of the 2016 ISCMP will be a regulatory white paper on continuous manufacturing of pharmaceuticals incorporating all of the learnings, and comments of the meetings and post-meeting discussions. The event highlighted the enormous progress made across the industry and academic community and the emerging challenges for industry adoption. CMAC, C-SOPS and RCPE have established I2APM after being granted SAVI funds. This collaboration has delivered a visiting academic from RCPE to CMAC in 2016 who contributed to integrating continuous synthesis and crystallisation techniques and an event and training day hosted by CMAC in late 2016 that has led to research exchanges between the three world leading Centres. Talent Pipeline and Skills Prof Alastair Florence is Director of the Centre and the embedded 45 student EPSRC Doctoral Training Centre (DTC), both led out of the University of Strathclyde. Approximately 70% of all researchers (65% of PhDs) are based at Strathclyde with the remainder spread across the remaining six institutions. Additional programmes in collaboration with NPL and NTU, Singapore have been initiated via Strathclyde based studentships aligned with the DTC as well as an SFC funded MSc in Advanced Pharmaceutical Manufacturing delivered by Strathclyde. So far the CMAC talent pipeline has delivered 19 researchers (10 PhD) who have gone to industry posts and 12 (5 PhD) to academic posts as first destination on leaving CMAC ( ~60% into industry). The quality of this talent pipeline has been deemed 'truly outstanding' by the Centres Independent Advisory Board whilst industry partners have commented on the ongoing need and demand of CMAC graduates. Establishment of CMAC Facility In March 2015 the Centre hub relocated to Strathclyde's new £100m Technology Innovation Centre (TIC). CMAC have secured a dedicated 1000m2 laboratory which is an award winning world-class facility for continuous manufacturing and Advanced crystallisation research. The facility and its dedicated team of scientists have capabilities and expertise in crystallisation, process development, materials characterisation, formulation and process and product analysis. The established CMAC Facility has attracted an initial industry income of £700k through new process and analysis projects in its early months of start-up. The facility was awarded the prestigious ISPE Facility of the Year (FOYA) 2016 Honourable Mention - the first time an academic facility has received this award. The facility spans a unique suite of advanced crystallisation and secondary processing technologies, state-of-the-art advanced materials characterisation combined with a PAT test bed and advanced control platforms. Further specialist characterisation capabilities have been supported through £2.5M EPSRC strategic equipment awards coupled with £0.75M from Wolfson Foundation towards the first ToF-SIMS instrument in Scotland. This unique capability is contributing to advanced understanding of process-product interactions to inform advanced manufacturing. Industry and translation CMAC has increased industrial engagement by new Tier 1 members Bayer joining in summer 2015 followed by EI Lilly, Roche and Takeda in late 2016. Tier 2 membership had reached 16 companies by the end of 2016. The Centre continue to work closely with other collaborators such as Syngenta, Black Trace and CPI through a range of projects including some funded jointly by EPSRC and Innovate UK. Impacts on our industry partners include: Novartis Use of CMAC's know-how and novel approach for introducing seeds into continuous crystallisation systems installed in Novartis Basel continuous plant. 'The introduction of continuous seeding approaches developed with CMAC into our scale-up operations allows for more consistent operation and predictable product properties' Ruairi O'Meadhra, Novartis Syngenta Continuous crystallisation feasibility study learning applied to a Syngenta batch process resulting in a 'de-bottlenecked' fungicide process. 'Overall it was a very valuable collaborative experience. I was really impressed that all the experiments in all equipment scenarios gave meaningful results. The project has led to insights which have changed the way we think about our crystallisation' David Ritchie, Syngenta Perceptive Engineering, AstraZeneca and CPI - MOPP CMAC, Perceptive Engineering, AstraZeneca and CPI collaborated on 'Dial-a-particle' model predictive control for lactose resulting in reduced particle size and improved control. 'CMAC has had an impact both on a national and international level in this area and AZ has benefitted substantially from being associated with the Centre' Jon-Paul Sherlock, AstraZeneca Acting as a National Centre As a National Centre we had a role to work with and on behalf of the wider community and to act as a focus for the wider research community in this area. We engaged, and continue to do so, with the wider community in this area, acting on their behalf e.g. to influence policy, facilitate and support workshops, meetings on topics within scope, support feasibility studies, develop national expertise and facility registers and remain a key contributor to the UK innovation landscape. The key benefits of a National Centre in terms of approaches to research critical mass and scale and research deliverables have already been highlighted. In addition, it is clear that the profile created from being a National Centre has also significantly boosted the opportunities available for training, equipment and facilities. This is illustrated by the success of additional funding from the DTC, RPIF, Wolfson, CMAC ICT and Manufacturing with Light awards. Being a National Centre has also enabled an abundance of engagements including those with EPSRC Grand Challenge networks, iCON PI's, CPI (HVM catapult), KTNs and collaborative TSB R&D projects which otherwise may not have been possible as a single research group. CMAC and the MIT-Novartis Centre co-organised the first International Symposium on Continuous Manufacturing of Pharmaceuticals (ISCMP) in 2014 and the second in September 2016. CMAC has also organised the 3rd EPSRC Manufacturing the Future Conference and three Open Day events to disseminate our research. Our most recent 2015 Open Day was attended by a total of 232 people from 82 organisations. We will host an Open Day in March 2017 that will showcase research outputs from the Centre from 2011-2016 and we expect over 250 delegates to attend. Further examples of where we have been able to use the National Centre to raise the profile of our work include her Majesty the Queen visiting our labs in TIC in July 2015 and the CEO of GSK, Sir Andrew Witty, visiting our labs in February 2016. 3. How CIM award findings are impacting public, private or other sectors As a National Centre team we have been active in contributing to developing strategy and influencing policy in the area of continuous manufacturing. To date the Centre is enthusiastically engaged with InnovateUK, SCI, IChemE, KTNs, CIA, RSC, CPI, NPL and is a member of ASPIRE. We have received press coverage from announcements from Rt Hon David Willets and Rt Hon Vince Cable M.P., who visited our facilities to officially open Phase I of our RPIF award. The Medicines Manufacturing Industry Partnership was established to advise government via the MISG on the needs of pharmaceutical manufacturing industry in the UK. CMAC was actively involved in reviews of skills needs, small molecule research and technologies innovation landscape that MMIP has used to inform its future programmes. Additionally, 8 white Papers from the joint CMAC-MIT International Symposium on Continuous Manufacturing of Pharmaceuticals were published to inform the global academic, industrial and regulatory community of experts. Contributions to the UK Manufacturing Review, Dowling Review, TSB Future of BioPharmaceutical High Value Manufacturing Deep Dive and Medicines Manufacturing Innovation Centre proposition development have influenced the national and international wider agenda in the future of advanced manufacturing. CMAC has engaged in delivering public outreach through school visits, Explorathon '16, an artist in residence and art exhibitions. We also have a web and social media presence (www.cmac.ac.uk, EPSRC_CMAC) and newsletter. 4. Challenges overcome to achieve impact The UK delivers world leading academic research and is home to some of the largest pharmaceutical manufacturing companies in the world. However translation of research outputs across the innovation system is a well recognised weakness in the UK. To address this, CMAC has worked in partnership with CPI of the HVM Catapult to develop a proposal to establish a new Medicines Manufacturing Innovation Centre (MMIC) to accelerate UK innovation in advanced pharmaceutical manufacturing technologies. With a £56M funding proposal currently under review with BEIS and Scottish Enterprise, if successfully established, this will provide a unique and route to implementation of CMAC developed technology and processes from 2019 onwards. We are working internationally through I2APM to establish a network of centres delivering collaborative international research as well as joint training and events. This will lead to higher impact research outputs and enable the international community to work together to collaborate on progressing solution to global challenges, deliver joint research and training drawing on world leading materials and skills, accelerating translation of research and adoption and influencing and facilitating interactions with regulators on a global scale. We have worked on collaborative R&D projects with industry partners as an effective mechanism to target TRL 4-6 translation of technology from the lab into new commercial services or products. Refer to specific outcomes of Made to Order Process Plants (EP/K504129/1) and Development of an Innovative Modular System for Continuous Chemical Processing (EP/K504117/1) for more detail.
Sector Agriculture, Food and Drink,Chemicals,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology
Impact Types Societal,Economic

 
Description AMECRYS - Continuous Template-Assisted Membrane Crystallisation H2020 FET OPEN
Amount £245,787 (GBP)
Funding ID 712965 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 10/2016 
End 09/2020
 
Description CORE - Continuous Resolution and Deracemization of Chiral Compounds by Crystallization MSCA ETN
Amount £898,439 (GBP)
Funding ID 722456 CORE 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 10/2016 
End 09/2020
 
Description Development of Continuous Processes for Separating Nucleation and Growth in Crystallisation of Pharmaceutical Products
Amount £3,875 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 03/2014 
End 05/2014
 
Description Development of an Innovative Modular System for Continuous Chemical Processing
Amount £1,000,000 (GBP)
Funding ID 101325 
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 03/2013 
End 02/2016
 
Description Doctoral Training Centre in Continuous Manufacturing and Crystallisation
Amount £6,000,000 (GBP)
Funding ID EP/K503289/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 07/2012 
End 12/2018
 
Description EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation
Amount £750,000 (GBP)
Funding ID EP/I033459/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 10/2011 
End 09/2016
 
Description Future Continuous Manufacturing and Advanced Crystallisation Research Hub
Amount £31,160,000 (GBP)
Funding ID EP/P006965/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 01/2017 
End 12/2023
 
Description ICT CMAC (Intelligent Decision Support and Control Technologies for Continuous Manufacturing and Crystallisation of Pharmaceuticals and Fine Chemicals)
Amount £2,545,065 (GBP)
Funding ID EP/K012450/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 02/2013 
End 01/2018
 
Description MOPP: Make to Order Processing Plants
Amount £760,000 (GBP)
Funding ID 101334 
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 02/2013 
End 04/2015
 
Description MSc in Continuous Manufacturing and Crystallisation
Amount £222,000 (GBP)
Organisation Government of Scotland 
Department Scottish Funding Council
Sector Public
Country United Kingdom
Start 04/2013 
End 09/2016
 
Description Manufacturing with Light
Amount £247,385 (GBP)
Funding ID EP/L022397/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 03/2014 
End 09/2015
 
Description Orbito
Amount £500,000 (GBP)
Funding ID 115369 
Organisation European Commission 
Department Innovative Medicines Initiative (IMI)
Sector Multiple
Country European Union (EU)
Start 10/2013 
End 09/2017
 
Description Pressure-Induced Nucleation for the Continuous Manufacture of supramolecular assemblies
Amount £966,179 (GBP)
Funding ID EP/N015401/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 06/2016 
End 05/2021
 
Description REMEDIES (RE-configuring MEDicines End-to-enf Supply)
Amount £2,241,062 (GBP)
Organisation Birmingham City Council 
Sector Public
Country United Kingdom
Start 07/2014 
End 06/2018
 
Description SAVI - International Institute for Advanced Pharmaceutical Manufacturing
Amount £248,175 (GBP)
Funding ID EP/M021661/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 10/2014 
End 09/2017
 
Description UK Research Partnership Investment Fund (UK RPIF) Capital Award
Amount £34,200,000 (GBP)
Organisation Higher Education Funding Council for England 
Sector Public
Country United Kingdom
Start 08/2013 
End 03/2015
 
Description UK Research Partnership Investment Fund (UK RPIF) Capital Award
Amount £34,200,000 (GBP)
Organisation Higher Education Funding Council for England 
Sector Public
Country United Kingdom
Start 08/2013 
End 03/2015
 
Description Wolfson Foundation Grant
Amount £750,000 (GBP)
Funding ID PR/cmf/19212 
Organisation The Wolfson Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2013 
End 09/2015
 
Title CMAC Electronic Laboratory Notebook (ELN) 
Description The CMAC Electronic Laboratory Notebook (ELN) is how CMAC captures experimental write up and data captured from the instruments housed in the CMAC National Facility. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact This database is being used to develop new informatics and modelling tools. 
 
Title Research data and algorithm supporting "Assessing the economic connectedness of the UK pharmaceutical and digital sectors by Input-Output Analysis" 
Description This document contains the raw input data used in computations; the results generated from such computations, and the dashboard visualizations of such results underpinning the associated conference paper. A MATLAB code provides the computational devices to implement the formulae presented in the paper, and to obtain the results outlined in the paper, and presented in the Excel files as well as in the Tableau dashboards. 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
 
Description CMAC membership organisation-AZ 
Organisation AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution An industrial membership organisation created to steer the development of user-led activities within the scope of the Centre, informing the basic research programmes and developing research for higher TRL activities. The three Tier 1 members are AstraZeneca, GlaxoSmithKline and Novartis. The industry contribution of significant cash support provides additional scope and pace to the programme and in particular allows the Centre and our industry partners to engage in higher TRL activity. The funds are managed by the CMAC membership board on which the EPSRC Centre Director and Industry Director are members to ensure alignment.
Start Year 2011
 
Description CMAC membership organisation-GSK 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution An industrial membership organisation created to steer the development of user-led activities within the scope of the Centre, informing the basic research programmes and developing research for higher TRL activities. The three Tier 1 members are AstraZeneca, GlaxoSmithKline and Novartis. The industry contribution of significant cash support provides additional scope and pace to the programme and in particular allows the Centre and our industry partners to engage in higher TRL activity. The funds are managed by the CMAC membership board on which the EPSRC Centre Director and Industry Director are members to ensure alignment.
Start Year 2011
 
Description CMAC membership organisation-Novartis 
Organisation Novartis
Country Global 
Sector Private 
PI Contribution An industrial membership organisation created to steer the development of user-led activities within the scope of the Centre, informing the basic research programmes and developing research for higher TRL activities. The three Tier 1 members are AstraZeneca, GlaxoSmithKline and Novartis. The industry contribution of significant cash support provides additional scope and pace to the programme and in particular allows the Centre and our industry partners to engage in higher TRL activity. The funds are managed by the CMAC membership board on which the EPSRC Centre Director and Industry Director are members to ensure alignment.
Start Year 2011
 
Description Centre joins A.SPIRE 
Organisation A.SPIRE
Country Belgium 
Sector Charity/Non Profit 
PI Contribution The EPSRC Centre became a member of A.SPIRE aisbl, an international non-profit association formed to represent the private sector as a partner in the Sustainable Process Industry through Resource and Energy Efficiency (SPIRE) Public-Private Partnership (PPP) to be launched as part of the Horizon2020 framework programme.
Start Year 2013
 
Description Cooling crystallisation 
Organisation BASF
Country Germany 
Sector Private 
PI Contribution Confidential
Start Year 2012
 
Description Crystallisation of food stuff 
Organisation Borregaard
Country Norway 
Sector Private 
PI Contribution Confidential
Start Year 2012
 
Description EP/I033459/1 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution University of Strathclyde researchers worked on this project with researchers from University of Edinburgh
Start Year 2011
 
Description Investigation of Crystallisation of an Agrochemical Product in an Oscillatory 
Organisation Syngenta International AG
Country Global 
Sector Public 
PI Contribution A commerical project involving the cooling crystallisation of an agrochemical product in an oscillatory baffled crystalliser. This is a KTA project with support from SyngentaCMAC and KTA univeristy budgets.
Start Year 2012
 
Description Investigation of telescoped continuous reaction and crystallisation in an oscillatory baffled reactor 
Organisation Fujifilm
Department Fujifilm Imaging Colourants
Country United States 
Sector Private 
PI Contribution The synthesis of a commercial dye via diazotisation and azo coupling, followed by temperature dependent crystallisation in an oscillatory baffled reactor. This was a KTA project with support from Fujifilm Imaging Colorants Lt
Start Year 2011
 
Description Joint research with Heriot-Watt University 
Organisation Heriot-Watt University
Country United Kingdom 
Sector Academic/University 
PI Contribution University of Strathclyde researchers worked on this project with researchers from Heriot-Watt University
Start Year 2011
 
Description Joint research with Loughborough University 
Organisation Loughborough University
Country United Kingdom 
Sector Academic/University 
PI Contribution University of Strathclyde researchers worked on this project with researchers from Loughborough University
Start Year 2012
 
Description Joint research with UNIVERSITY OF NEWCASTLE 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution University of Strathclyde researchers worked on this project with researchers from UNIVERSITY OF NEWCASTLE
Start Year 2012
 
Description Joint research with University of Bath 
Organisation University of Bath
Country United Kingdom 
Sector Academic/University 
PI Contribution University of Strathclyde researchers worked on this project with researchers from University of Bath
Start Year 2011
 
Description Joint research with University of Cambridge 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution University of Strathclyde researchers worked on this project with researchers from University of Cambridge
Start Year 2011
 
Description New Collaboration with Dr Brahim Benyahia, Loughborough University 
Organisation Loughborough University
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-supervisor for new DTC project commencing October 2013 with Prof Chris Rielly. Dr Brahim Benyahia will be contributing to the Centre with the co-supervision of researchers within the Doctoral Training Centre commencing October 2013.
Start Year 2013
 
Description New Collaboration with Dr Jag Srai, University of Cambridge 
Organisation University of Cambridge
Department Institute for Manufacturing
Country United Kingdom 
Sector Academic/University 
PI Contribution Dr Jag Srai has been involved with the EPSRC Centre from the beginning of the grant. Dr Jag Srai has vast expertise in manufacturing operations and supply chain management, which is vital for the progression of the EPSRC Centre against its key research themes.
Start Year 2011
 
Description New Collaboration with Prof Alex Mullen, University of Strathclyde 
Organisation University of Strathclyde
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-supervision of Centre PhD researcher at the University of Strathclyde. Professor Alex Mullen is contributing the Centre through the co-supervision of PhD researcher Fracesca Perciballi.
Collaborator Contribution Alex is second supervisor to a Centre PhD student
Impact this project will result in FP gaining a PhD qualification. She has been recruited by a Tier 1 partner on completion of her studies.
Start Year 2013
 
Description New collaboration with Dr Alison Nordon, University of Strathclyde 
Organisation University of Strathclyde
Country United Kingdom 
Sector Academic/University 
PI Contribution Dr Alison Nordon has become more involved in the EPSRC Centre and has recently been formalised as a Co-Investigator through EPSRC. Dr Alison Nordon has expertise in any analytical techniques including non-invasive Raman, ATR-FTIR and passive acoustic measurements. This along with her expertise in data analysis and improving calibration models will be a great asset to the EPSRC Centre.
Start Year 2013
 
Description New collaboration with Dr Andrew Alexander, The University of Edinburgh 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-supervisor for new Centre PhD project commencing October 2012 with Prof Colin Pulham. Dr Andrew Alexander is contributing with the co-supervision of PhD researcher Alasdair Mackenzie at the University of Edinburgh.
Start Year 2012
 
Description New collaboration with Dr Blair Johnston, University of Strathclyde, ICT 
Organisation University of Strathclyde
Country United Kingdom 
Sector Academic/University 
PI Contribution Involved in ICT Project. Dr Blair Johnston has contributed to the Centre with his expertise in ICT. He is instrumental in the introduction of Electronic Lab Notebooks (ELN) to all Centre researchers and has introduced ULab, an electronic laboratory equipment booking system that can be used for cross-centre equipment sharing.
Start Year 2013
 
Description New collaboration with Dr Dimitrios Lamprou, University of Strathclyde, MSc Course 
Organisation University of Strathclyde
Country United Kingdom 
Sector Academic/University 
PI Contribution A new MSc in Advanced Pharmaceutical Manufacturing aligned with Continuous Manufacturing and Crystallisation (CMAC) has been supported by the Scottish Funding Council. Dr Dimitrios Lamprou is contributing to the EPSRC Centre in his capacity of MSc academic coordinator and as supervisor / second supervisor to CMAC DTC researchers. His skills will help progress the MSc programme to make it a UK leading course in continuous manufacturing and crystallisation.
Collaborator Contribution supervision / second supervisor for 4 CMAC DTC researchers. MSc co-ordinator for MSc in Advanced Pharmaceutical Manufacturing
Impact Establishment of MSc in Advanced Pharmaceutical Manufacturing
Start Year 2013
 
Description New collaboration with Dr Iain Oswald, University of Strathclyde 
Organisation University of Strathclyde
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-supervisor for new DTC project commencing October 2013 with Prof Alastair Florence. Dr Iain Oswald will be contributing to the Centre with the co-supervision of researchers within the Doctoral Training Centre commencing October 2013.
Start Year 2013
 
Description New collaboration with Dr Mark Haw, University of Strathclyde 
Organisation University of Strathclyde
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-supervisor for new DTC project commencing October 2013 with Dr Jan Sefcik. Dr Mark Haw will be contributing to the Centre with the co-supervision of researchers within the Doctoral Training Centre commencing October 2013.
Start Year 2013
 
Description New collaboration with Dr Mark Symes, University of Glasgow 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Becoming involved in CMAC with Prof Lee Cronin. Dr Mark Symes is an early career research fellow at the University of Glasgow and has been introduced to the Centre as an avtive collaborator.
Start Year 2013
 
Description Polymerisation of expandable polystyrene 
Organisation BASF
Country Germany 
Sector Private 
PI Contribution Confidential
Start Year 2012
 
Description Project partnership with Astra Zeneca 
Organisation AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution Astra Zeneca worked with the research team and assisted/contributed to the project outcomes. CMAC poroducced kgs of material for pharmaceutical research for AZ of specified particle size distribution
Collaborator Contribution CMAC use approach and equipment developed through the project to make material that would have required significantly more time and effort to make before the project occurred.
Impact Continuned reserach programmes and agreements with AZ ~ 5 confidential proujects have resulted form teh partnership developed during the MOPPs project
Start Year 2016
 
Description Project partnership with Fujifilm Imaging Colorants Ltd 
Organisation Fujifilm
Department Fujifilm Imaging Colourants
Country United States 
Sector Private 
PI Contribution Fujifilm Imaging Colorants Ltd worked with the research team and assisted/contributed to the project outcomes
Start Year 2011
 
Description Project partnership with Genzyme Ltd 
Organisation Sanofi
Department Genzyme Corporation
Country United States 
Sector Private 
PI Contribution Genzyme Ltd worked with the research team and assisted/contributed to the project outcomes
Start Year 2011
 
Description Project partnership with Glaxo Smithkline (UK) 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Glaxo Smithkline (UK) worked with the research team and assisted/contributed to the project outcomes
Start Year 2011
 
Description Project partnership with Pfizer US 
Organisation Pfizer Ltd
Country United Kingdom 
Sector Private 
PI Contribution Pfizer US worked with the research team and assisted/contributed to the project outcomes
Start Year 2011
 
Description Project partnership with Phoenix Chemicals Limited 
Organisation Phoenix Chemicals Limited
Country United Kingdom 
Sector Private 
PI Contribution Phoenix Chemicals Limited worked with the research team and assisted/contributed to the project outcomes
Start Year 2011
 
Description Project partnership with Solid Form Solutions Limited 
Organisation Solid Form Solutions Limited
Country United Kingdom 
Sector Private 
PI Contribution Solid Form Solutions Limited worked with the research team and assisted/contributed to the project outcomes
Start Year 2011
 
Title Device for Inducing Nucleation 
Description The patent refers to a device that separates the two operations of crystal nucleation and crystal growth, and can be described as being similar to a two stage continuous oscillatory baffled crystalliser (COBC). 
IP Reference WO2013088145 
Protection Patent granted
Year Protection Granted 2013
Licensed No
Impact The device is significantly cheaper and more reliable than known ultrasound devices and facilitates the separation of crystal nucleation and crystal growth. The device also enables the avoidance of the use of seeding as a source of secondary nucleation
 
Description BCA/CCG Intensive Teaching School in X-ray structure analysis 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Lauren Agnew and Anneke Klapwijk partook in the 15th BCA/CCG Intensive Teaching School in X-ray structure analysis held at Trevelyan College in Durham from the 21st-29th March. The school aims to provide a detailed understanding into the determination and analysis of crystal structures, as well as the fundamental principles of crystallography.

Improved knowledge and networking
Year(s) Of Engagement Activity 2015
 
Description CGOM-10, June 2012 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact "Wilson, C.C., Structural Chemistry and Crystallisation: a Journey from Advanced Facilities to Flow, CGOM-10, Limerick, June 2012.
"


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2012
 
Description CMAC Open Day 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact "The CMAC Open Day 2017, showcasing progress from the last five years will take place in TIC, University of Strathclyde on 23-24 March 2017. The event will have a focus on developments in key areas of manufacturing research enabling continuous manufacturing and future directions.
The programme will include:
• Presented highlights from CMAC CIM research programme
• Posters from all CMAC Researchers
• Excellent networking opportunities with internationally leading academics and industrialists
• Exhibitions from our world leading Tier 2 Partners
• Tours of the CMAC National Facility
• Conference Dinner
Year(s) Of Engagement Activity 2016
URL https://www.cmac.ac.uk/CMAC_Open_Day_2017.htm
 
Description Digital Technologies for Manufacturing Innovation: Embracing Industry 4.0 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact CMAC Centre Manager Dr Andrea Johnston attended Digital Technologies for Manufacturing Innovation: Embracing Industry 4.0. The event was organised by the Institute for Advanced Manufacturing (ifAM) at The University of Nottingham, in conjunction with EPSRC and Innovate UK.
Year(s) Of Engagement Activity 2015
 
Description Presentation at ACHEMA 2012 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Ni, XW.: Flow chemistry technology handling solids including crystallisation. ACHEMA, Frankfurt, Germany, 18th June 2012.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2012
 
Description "The Structure of Stuff is Sweet" - includes polymorphism and crystallisation 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact EPSRC Centre Researcher Lynne Thomson gave a presentation/lecture.

Presenting at the British Science Festival in Newcastle.
Year(s) Of Engagement Activity 2013
 
Description 03 April 2017 edition of Chemistry World. "The flow revolution" 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Article in Chemistry World Magazine that includes CMAC
Year(s) Of Engagement Activity 2017
URL https://www.chemistryworld.com/feature/the-flow-revolution/2500496.article
 
Description 10TH WORLD MEETING on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact "The 10TH WORLD MEETING on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology took place in Glasgow from 4-7th April 2016. CMAC was one of the organisations involved with CMAC Director Prof Alastair Florence being a member of the organising committee for the conference and also chairing an afternoon session on Tuesday. CMAC researchers attended the meeting - CMAC DTC Students Elanor Brammer and Laura Martinez Marcos presented their posters.
Elanor M. Brammer, Gavin W. Halbert, Dimitrios A. Lamprou. An Investigation into Fused Filament Fabrication for Pharmaceutical Manufacturing.
Year(s) Of Engagement Activity 2016
 
Description 16 November , The Scotsman, "Fast-track medicine base in Scotland could be a game changer" . 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article about CMAC in Scotsman newspaper / online
Year(s) Of Engagement Activity 2017
URL https://www.scotsman.com/business/fast-track-medicine-base-in-scotland-could-be-a-game-changer-1-461...
 
Description 22nd International Annual European Operations Management Association (EurOMA) Conference 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Harrington, T.S., Srai, J.S. 'Evaluating reconfigured Pharmaceutical value chains', 22nd International Annual European Operations Management Association (EurOMA) Conference


Dissemination of CMAC research
Year(s) Of Engagement Activity 2015
URL http://www.euroma2015.org/
 
Description 24 May 2017 , Pharmaceutical Online "Developing Mobile Continuous Process Technology: A Collaborative Innovation Case Study" . 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Press release about CMAC and REMEDIES project
Year(s) Of Engagement Activity 2017
URL https://www.pharmaceuticalonline.com/doc/developing-mobile-continuous-process-technology-a-collabora...
 
Description 26 January 2017 edition of Chemical Engineer Magazine "Continuous Collaboration" . 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Article in Chemical Engineer Magazine that outlines the CMAC activities including research, training, facilities and translation into industry.
Year(s) Of Engagement Activity 2017
URL https://www.thechemicalengineer.com/features/continuous-collaboration/
 
Description 26th Annual Production and Operations Management Society (POMS) Conference 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Harrington, T.S. 'Emerging product-process archetypes in oncology: Implications for supply network design', 26th Annual Production and Operations Management Society (POMS) Conference, Washington DC

Dissemination of CMAC research
Year(s) Of Engagement Activity 2015
URL http://www.pomsmeetings.org/EventsNet/?pr=1&ev=60
 
Description 28th November , featured in the Herald, "Alastair Florence: 'The key to success is working pre-competitively with industry' 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article about CMAC in the Herald newspaper and online
Year(s) Of Engagement Activity 2017
URL http://www.heraldscotland.com/business_hq/15687920.Alastair_Florence___The_key_to_success_is_working...
 
Description 2nd International Symposium on Continuous Manufacturing of Pharmaceuticals 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact "2nd International Symposium on Continuous Manufacturing of Pharmaceuticals
CMAC and MIT co-hosted the 2nd International Symposium on Continuous Manufacturing of Pharmaceuticals (ISCMP) in Boston on 26-27 September 2016. CMAC jointly arranged this conference. Prof Alasatir Florence was Session Chair: Small Molecule Case Studies and Panel Discussion. There were also sessions on bioprocessing, learning from other industries, and regulatory and quality. After the 2014 event 8 significant white papers were produced link http://iscmp2014.mit.edu/white-papers. One of the major outputs will be writing a regulatory white paper on continuous manufacturing of pharmaceuticals.
"
Year(s) Of Engagement Activity 2016
 
Description 3rd CMAC Annual Review 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Supporters
Results and Impact Brochure showcases all the activities and progress CMAC has made to date

Used to show potential new collbaorators what CMAC does
Year(s) Of Engagement Activity 2014
 
Description 4th Winter Process Chemistry Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Hosted by 'EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC)' at The University of Strathclyde, the the 4th Winter Process Conference was held in TIC, Glasgow from 12-14 Dec 2017. It had presentations from International Chemists and Chemical Engineers covering all aspects of Process Development. This included a keynote lecture from Professor Alastair Florence titled 'Adventures in Crystallisation: Polymorphs, Particles and Platforms' and poster presentations from Dr Cameron Brown, Dr Andrea Johnston, Dr Vijay Srirambhatla, Fraser Mabbott and Rebecca Halliwell. ". Dr Wolfgang Beckmann from Bayer AG, a CMAC Tier 1 partner, gave a talk " Habit Modification for Easier Down-Stream Processing". CMAC had a stand at the event and gave lab tours of the CMAC National Facility to visitor attending the conference.
Year(s) Of Engagement Activity 2016
 
Description 7th APS International PharmSci Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact CMAC had a significant presence at the 7th APS International PharmSci Conference that took place in TIC from 5-7 September. CMAC Investigator Prof Gavin Halbert gave the plenary lecture on the Wednesday, CMAC researchers Carlota Mendez and Eleonora Paladino presented their work. There were posters from Eleonora Paladino, Alice Turner, Sarahjane Wood, Carlota Mendez, Tariq Islam, and Thidarat Wongpinyochit. CMAC and several of the Tier 2 companies had presence via exhibition stands. CMAC ran daily lab tours of the CMAC National Facility during the conference which proved to be very popular.
Year(s) Of Engagement Activity 2016
 
Description AAPS 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Dr Tariq Islam, a CMAC Research Associate on the Remedies project, presented a at the AAPS annual meeting 2016, where he talked about the current outcome from our ongoing research and showed our capabilities in making 3D printed solid dosage forms after extrusion via filament formation. The reference for the poster is shown below.
M.T. Islam, J. Robertson, A.J. Florence, Initial Assessment of Hot-melt extrusion for processing API with a wide range of physical properties to form consistent solid dispersion: HPMC-Affinisol™ Paracetamol system (for 3D printing medicine), AAPS annual meeting 2016, Denver, Colorado, USA.
Year(s) Of Engagement Activity 2016
 
Description AIChE 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact CMAC DTC Researcher John McGinty (Sefcik Group) attended the AIChE 2016 annual meeting from 13-18th November. John delivered the following presentation: McGinty, J., Price, C., & Sefcik, J. (2016, November). Continuous Reactive Crystallisation for Control of Salt Formation Processes. Presented at the AIChE 2016 annual meeting, San Francisco, USA.
Year(s) Of Engagement Activity 2016
 
Description American Control Conference 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Oral presentation at the American Control Conference, 2015, Hilton Palmer House, Chicago, Illinois, US, 1-3 July 2015 Qinglin Su, Chris D. Rielly, Zoltan K. Nagy, "Simultaneous Design and Control Framework for Multi-segment Multi-addition Plug-flow Crystallizer for Anti-solvent Crystallizations"

Dissemination of CMAC research
Year(s) Of Engagement Activity 2015
URL http://acc2015.a2c2.org/
 
Description Article in Scotsman posted: 12/02/2015 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Clive Badman, Industrial Chairman of CMAC, interviewed for article in Scotsman. The article describes how CMAC is at the forefront of research into changing the way pharmaceuticals are manufactured.

Scottish newspaper and internet publication to reach public
Year(s) Of Engagement Activity 2015
URL http://www.scotsman.com/news/comment-tackling-increased-demand-for-medicine-1-3686254
 
Description Attended ProcessAbility 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Siddique, H.: ProcessAbility, P&G Brooklands General Offices, The Heights, Weybridge, Surrey. 20th & 21st October, 2014


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2014
 
Description BACG 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Professor Florence is Chair of BACG and CMAC had a large presence at the annual conference.
talks:
Adelakun, J., (2016, June) Kinetics Study of Melt Crystallisation (Palm Oil as Case study) at the joint BACG2016 & CGOM12 conference, Leeds, UK
Agnew, L., McGlone, T., Wilson, C.C., (2016, June) Towards Multi-component Templated Continuous Crystallisation of Paracetamol Form II at the joint BACG2016 & CGOM12 conference, Leeds, UK
Kendall, T., (2016, June) Filtration Suppresses Laser Induced Nucleation of Glycine in Aqueous Solutions at the joint BACG2016 & CGOM12 conference, Leeds, UK
Ottoboni, S., Chrubasik,M., Bruce,L.M., Nguyen, H., Johnston,B.,Florence, A., Price, C., (2016, June) The impact of paracetamol impurities on face-specific properties: investigating the surface of single crystals using TOF-SIMS at the joint BACG2016 & CGOM12 conference, Leeds, UK
Posters
Cousen, A., (2016, June) Selective Preparation of Polymorphic, Stoichiometric and Enantiomeric Multi-component Materials. Poster presented at the joint BACG2016 & CGOM12 conference, Leeds, UK.
Ejim, L., (2016, June) A Design of Experiment (DoE) Approach to Optimize the Inner Geometry of Baffled Meso-scale Tubes for Continuous Crystallization. Poster presented at the joint BACG2016 & CGOM12 conference, Leeds, UK.
Fysikopoulos, D., (2016, June) Parameter Identification, Reliability and Model Discrimination of Population Balance Models for Crystallization. Poster presented at the joint BACG2016 & CGOM12 conference, Leeds, UK.
Kimuli, E., (2016, June) Determining Residence time distribution and axial dispersion coefficient in meso-scale oscillatory baffled crystallizer using a Computational fluid dynamics approach. Poster presented at the joint BACG2016 & CGOM12 conference, Leeds, UK.
McGinty, J., Price, C., & Sefcik, J. (2016, June). Continuous Reactive Crystallisation for Control of Salt Formation Processes. Poster presented at the joint BACG2016 & CGOM12 conference, Leeds, UK.
Svoboda, V., (2016, June) Continuous Antisolvent Co-crystallization of Benzoic Acid and Isonicotinamide. Poster presented at the joint BACG2016 & CGOM12 conference, Leeds, UK
Steendam, R.R.E., Bruiglia, M., Sefcik, J., ter Horst, J.H., (2016, June). Primary and Secondary Nucleation of Chiral Crystals. Poster presented at the joint BACG2016 & CGOM12 conference, Leeds, UK.
Yang, H.; Yu, X. ; Raval, V. ; Makkawi, Y.; Florence, A.; (2016, June) Poster presentation, Shear rate and nucleation rate in oscillatory flow crystallizer Poster presented at the joint BACG2016 & CGOM12 conference, Leeds, UK.
Year(s) Of Engagement Activity 2016
 
Description BIWIC 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact "BIWIC 2016 - 23rd International Workshop on Industrial Crystallization
Prof. Joop ter Horst, Dr. René Steendam and DTC Researcher Maria Briuglia have attended the BIWIC that took place 6-8th September 2016 in Magdeburg, Germany. Maria and René presented their work with a poster and additional projects that Joop is involved with were presented with two talks.
Posters:
R. R. E. Steendam & J. H. ter Horst.; "Continuous Crystallization of Enantiopure Crystals through Secondary Nucleation".
M. L. Briuglia, J. H. ter Horst & J. Sefcik.; "Crystal Nucleation within the Metastable Zone".

Talks:
P. Kongsamai, A. Maneedaeng, C. Flood, J.H. ter Horst, Adrian Flood.; "The mechanism by which additives improve the preferential crystallization of L-asparagine monohydrate".
W. W. Li, H.J.M. Kramer, J.H. ter Horst, "Temperature cycling induced deracemization of a racemic compound via its conglomerate salt".

"
Year(s) Of Engagement Activity 2016
 
Description CEO of EPSRC Visits CMAC 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact CEO of EPSRC Visits CMAC
On Wednesday 26th Oct 2016 EPSRC CEO Professor Philip Nelson visited the University of Strathclyde. CMAC Director Prof Alastair Florence participated in the visit which included a University wide presentation and a roundtable. As part of the day, Philip Nelson and and Amanda Chmura (Head of University Relationships and Business Engagement at EPSRC) toured the CMAC National Facility with Alastair
Year(s) Of Engagement Activity 2016
 
Description CEO of The Wolfson Foundation, visited CMAC 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Supporters
Results and Impact Paul Ramsbottom, CEO of The Wolfson Foundation, visited the Technology and Innovation Centre on Thursday 26th November alongside Mr Glen Watson (MBA). Paul's visit included a visit to the TOF-SIMS in the newly named 'Wolfson Pharmaceutical Surfaces Laboratory', whereby Prof. Alastair Florence and Dr Dimitrios Lamprou gave him a brief explanation of its features, the benefits towards Centre research and thanked the foundation for their generous donation towards excelling CMAC's capabilities.
Year(s) Of Engagement Activity 2015
 
Description CMAC Annual Open Day 2015 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The CMAC Annual Open Day 2015 took place on 23rd and 24th September at Technology and Innovation Centre, University of Strathclyde, Glasgow.

Prizes:
Paul Sharratt from ICES presented the awards for Best Poster, Best Oral Presentation and CMAC Annual Research Prizes; and Craig Johnston, CMAC Industry Director presented the CMAC Science as Art prize.

Best Poster Presentation
1st place: Martin Ward, Runners- up: Bilal Ahmed and Anneke Klapwijk. Special mentions: Rajesh Gurung, Ebenezer Ojo.

Best Oral Presentation
1st place: Daniel Ward, Runner- up: Laura Martinez-Marcos

CMAC Annual Research Prize: Early Career Researcher
Winner: Thomas McGlone, Special mention: Murray Robertson

CMAC Annual Research Prize: Doctoral Trainee
Winner: Keddon Powell, Special mention: Kate Wittering

CMAC Science as Art
1st place: Rajesh Gurung, 2nd place: Carlota Mendez Torrecillas
The Open Day programme included:
• Talks from key industry and invited academic speakers
• Tours of the new CMAC National Facility
• Posters presented by all Centre researchers: available on request
• Exhibitions from a range of world leading technology companies
• Excellent networking opportunities
• Conference Dinner
Session Themes: Crystallisation, Secondary Processing, Modelling and Control.

If you are interested in finding out more about any of the talks or posters please contact info@cmac.ac.uk .




Dissemination of CMAC research
Year(s) Of Engagement Activity 2015
 
Description CMAC Annual Review 2014-2015 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Supporters
Results and Impact CMAC Annual Review 2014-2015 is availble in print or online
Year(s) Of Engagement Activity 2015
URL https://dl.dropboxusercontent.com/u/110796764/cmac2015/index.html
 
Description CMAC Annual Review 2015-2016 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Supporters
Results and Impact Our latest CMAC Annual Review 2015-2016 was published in Nov 2016. It showcases the achievements of the CMAC EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation that has run from 2011-2016.
Year(s) Of Engagement Activity 2016
 
Description CMAC Mentioned in Biopharminternational Article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact CMAC Mentioned in Biopharminternational Article
posted: 01/03/2016

A recent article on the Biopharminternational website mentions CMAC being partners in the $29-million Advanced Digital Design of Pharmaceutical Therapeutics (ADDoPT)program, part of the UK's Advanced Manufacturing Supply Chain Initiative. http://www.biopharminternational.com/can-better-modeling-reduce-pharmaceutical-development-and-manufacturing-costs-0
Year(s) Of Engagement Activity 2016
URL http://www.biopharminternational.com/can-better-modeling-reduce-pharmaceutical-development-and-manuf...
 
Description CMAC at Explorathon '16 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Explorathon '16 is took place across Scotland on 30th September. As part of this, a group of CMAC researchers visited Aultmore Primary School in Glasgow to give a series of demos on crystallisation and then exhibited at the Explorathon Extravaganza at Glasgow Science Centre in the evening. Our "the crystal builders" demo proved to be very popular and used 14kg of marshmallows and 3000 cocktail sticks! Delivered by our team of CMAC DTC researchers.
Year(s) Of Engagement Activity 2016
 
Description CMAC mentioned in Article in Professional Engineer magazine and on www.imeche.org website 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact "CMAC mentioned in Professional Engineer Magazine
Welcome prescription, an article in Professional Engineer magazine by Ben Sampson on 05 November 2014, mentioned CMAC. The article reported on how a switch to continuous manufacturing could increase automation of the production of drugs and help the pharmaceutical industry respond to diseases like ebola.
http://www.imeche.org/news/engineering/welcome-prescription
"


The Professional Engineer is the magazine for the Institute of Mechanical Engineers. The article is on the web.
Year(s) Of Engagement Activity 2014
URL http://www.imeche.org/news/engineering/welcome-prescription
 
Description CMAC participation in British Council Workshop, Novosibirsk, Siberia 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact CMAC participation in British Council Workshop, Novosibirsk, Siberia
From 9-13th February 2015 Dr Thomas McGlone, (CMAC PDRA, University of Strathclyde), Dr Karen Robertson (CMAC PDRA, University of Bath) and Adam Michalchuk (DTC, University of Edinburgh) attended 'Molecular Materials - from fundamentals to applications' in Novosibirsk, Siberia. This early career researcher scientific workshop was sponsored by the British Council and the RSC and was co-organised by CMAC's PI Prof. Colin Pulham and Prof. Elena Boldyreva (Novosibirsk University). Esteemed colleagues in our field including Prof. Sally Price (CPOSS), Prof Joel Bernstein and Prof Bill Jones (CMAC Advisory Board) were in attendance.



Esteemed colleagues in our field including Prof. Sally Price (CPOSS), Prof Joel Bernstein and Prof Bill Jones (CMAC Advisory Board) were in attendance.
Year(s) Of Engagement Activity 2015
URL http://www.iucr.org/calendar/events/topics/general/name-molecular-materials-from-fundamentals-to-app...
 
Description CPhI Barcelona 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact The CMAC National Facility team exhibited at CPhI Barcelona 2016. This is a three-day exhibition which had over 30,000 delegates in attendance. Craig Johnston, CMAC Industrial Director, also presented during the pre-connect conference on Monday 3rd October together with Johnathon Marshall, PwC, on Continuous Processing in Manufacturing.
Year(s) Of Engagement Activity 2016
 
Description Cambridge Crystallographic Data Centre Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact On 11th October 2016, Dr Murray Robertson hosted Andy Maloney and Mat Bryant from the Cambridge Crystallographic Data Centre for the CMAC CSDS Training Day.  There was an introductory lecture attended by 39 CMAC researchers followed by three workshops on the topics of ConQuest, Mercury and Python API.  This proved to be a productive day with some very positive feedback from the participants and the facilitators.
Year(s) Of Engagement Activity 2016
 
Description Chemical Sciences Scotland publications in ICIS Chemical Business Magazine and website 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Craig Johnston, Operations Director, CMAC was interviewed for October 2014 ICIS Chemical Business Magazine and ICIS website: Chemicals in Scotland Supplement p10 Supplement:

Clive Badman, Executive Director at CMAC gave an interview for October 2014 ICIS Chemical Business Magazine and ICIS website: ICIS Interactive, Chemicals in Scotland: Focused on the Future Interactive:http://edition.pagesuite-professional.co.uk/launch.aspx?eid=b0a8c8a4-3475-4de2-822f-5d65a7b2cb50 . Clive Badman's interview- http://youtu.be/meFumtqJtnE


This was published on the website and in the Magazine for ICIS members.
Year(s) Of Engagement Activity 2014
URL http://edition.pagesuite-professional.co.uk/launch.aspx?eid=86874fd9-6dd7-42e3-a1bc-5339be08ed08
 
Description Chief Scientific Officer Visits CMAC 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact "Chief Scientific Officer Visits CMAC
Professor Sir Mark Walport (Government's Chief Scientific Advisor)and Dr Neil Waby (Climate Change & Energy Policy Adviser) visited CMAC's X-ray Suite earlier this year where they met key CMAC people and were introduced to our world leading suite of instruments on structural characterisation and analysis and the role it plays in manufacturing and pharmaceutical development.
"
Year(s) Of Engagement Activity 2016
 
Description Continuous Manufacturing Technology Roadmapping Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact "Continuous Manufacturing Technology Roadmapping Workshop
In June 2016, Craig Johnston, Industry Director at CMAC and Dr Cameron Brown, Senior Instrument Scientist for Continuous Processing, attended the Continuous Manufacturing Technology Roadmapping Workshop, co-hosted by C-SOPS and USP and held in Washington. Craig and Cameron attended presentations from academic, industry and regulatory delegates, and Cameron also participated in a panel discussion on the following topic - "Identify Achievable Target for API CM, Assessment of Capabilities, Gap Analysis and How to Overcome Barriers".
"
Year(s) Of Engagement Activity 2016
 
Description Crystallisability 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Florence, A. F.:Controlling Crystallisation. In CrystallisAbility, Jealott's Hill, 2013.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2013
 
Description Crystallize COST Action Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Crystallize COST Action Meeting
CMAC's Prof Joop ter Horst and Dr René Steendam recently attended the Crystallize COST Action meeting in Berlin (23-24 November 2015). A variety of topics were presented. Highlights included:
• Co-crystal formation and in-situ XRPD in a crystallizer during solvent-mediated phase transformation (Gerard Coquerel)
• Monitoring of molecular interactions (Sven Schroeder)
• Nucleation in droplets (Romaine Grossier)
• Pharmaceutical co-crystals (Ricardo Castro)
• Molecular simulations (Marcus Weber)
• Protein crystallization (Elias Vlieg)
COST is a unique networking platform where European researchers can jointly develop their own ideas and new initiatives across all scientific disciplines through trans-European networking of nationally funded academics.
Year(s) Of Engagement Activity 2015
URL http://www.cost-crystallize.com/
 
Description Diamond Open Day, June 2013 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact EPSRC Centre Researcher Lynne Thomas, and DTC PhD Researcher Anneke Klapwijk.
Year(s) Of Engagement Activity 2013
 
Description ECCPM Workshop on Process Control 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact "ECCPM Workshop on Process Control
In July 2016, Dr Cameron Brown, Senior Instrument Scientist for Continuous Processing, and Dr Claire MacDonald, National Facility Business Development Manager, attended the ECCPM Workshop on Process Control, hosted by RCPE in Graz, Austria. In addition to the workshop, Cameron and Claire met with Centre Director Johannes Khinast, Director of Scientific Operations Massimo Bresciani and Ass. Prof Heidi Gruber-Woefler, and were given a tour of the facility to see the new RCPE pilot plant.
"
Year(s) Of Engagement Activity 2016
 
Description ERICE 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact CMAC academics Chris Price, Joop ter Horst and Zoltan Nagy alongside DTC students Lauren Agnew (Bath), Anneke Klapwijk (Bath) and Maria Briugia (Strathclyde) attended Erice 2015, Sicily 5th -14th June 2015 for the 48th annual International School of Crystallography course. The 8 day course is entitled "Engineering Crystallography : from molecule to crystal to functional form" and consists of a series of lectures from leading academics across the area of crystallography and crystallisation. Anneke Klapwijk won a poster prize.


Dissemination of CMAC research
Year(s) Of Engagement Activity 2015
URL http://crystalerice.org/Pastactivity/2015/2015.htm
 
Description Engage With Strathclyde 2016 - CMAC 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact On 4th May 2016 CMAC held an event at Engage With Strathclyde - Collaboration with the Centre for Continuous Manufacturing and Crystallisation (CMAC). This event was designed to bring together CMAC Tier 2 companies and our academics and researchers to explore how we can collaborate moving forward. There were 26 flash presentations hosted within half a day to give an excellent overview of the projects, technology and collaborations between the Tier 2 Technology companies and CMAC researchers. We also had a pre event networking dinner around the Images of Research where discussions took place, and an afternoon event where PwC hosted and presented an excellent showcase. Thanks to all the companies, researchers, academics and Engage with Strathclyde who made this event a great success. Contact: stewart.mitchell@strath.ac.uk

Engage with Science: Boost Business
CMAC was also represented at the Engage with Science: Boost Business science faculty event where Centre Manager Dr Andrea Johnston gave a talk, "Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC)".

Hyperspectral Imaging: Monitoring Continuous Production of Pharmaceuticals and Fine Chemicals (ICT-CMAC Project)
The CMAC National Facility was showcased as part of the ICT CMAC demonstrations that took place as part of Engage With Strathclyde. Each one-hour demonstration included a short introduction to the project, a showcase of the hyperspectral imaging method, followed by a tour of the world-leading facilities.

CMAC DTC researcher Vaclav Svoboda was the overall winner at this year's University of Strathclyde Images of Research Competition. Vaclav who is in Professor Jan Sefcik's group, had won the "Innovative Engineering" category for his image "Hidden Colours of Crystallisation" which was taken using the Leica DM6000 M microscope housed in the CMAC National Facility. Research associate Dr Rene Steendam, who is in CMAC Academic Prof Joop Ter Horst's group, and was runner up in the "Size Matters" category with his Image "Manufacturing the Right Crystals".
Images of Research is an annual competition at University of Strathclyde that offers a unique opportunity to captivate an audience through an eye catching image, and successful entries are offered the chance to showcase their research to a public audience of thousands throughout the West of Scotland. Gallery of Images of Research is online.
Year(s) Of Engagement Activity 2016
URL http://www.imagesofresearch.strath.ac.uk/2016/gallery.php
 
Description Engineering Yes 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact "CMAC Researchers Iyke Onyemelukwe and Emmanuel Kimuli, both based at Loughborough were part of a team that took part in Engineering YES , a government and industry funded entrepreneurship training competition for engineers and scientists. The team named "Green Beauty Technology" won the best team prize in Heat 2 which took place between 17th May and 20th May at the Holiday Inn Birmingham M6.
The idea behind "Green Beauty Technology" was to produce a new type of water-based nail polish using natural ingredients, and in particular natural pigments from waste food, such as using beetroot for making the red colour. The production process was self- fuelled since the organic waste from the production of the pigment was to be used for making energy from a bio reactor.
"


Outreach activity
Year(s) Of Engagement Activity 2015
URL http://www.engineeringyes.org/
 
Description Filtration Event 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Dr Chris Price and DTC researcher Sara Ottoboni attended the Filtration Event 2016 from 11-13th October 2016 in Cologne, Germany. Sara presented a talk on work done in collaboration with AstraZeneca and Alconbury Weston: S. Ottoboni, C.J. Price, C. Steven, E. Meehan, A. Barton, A. Mitchell.; "Development of a Novel Continuous Filtration Unit for Pharmaceutical Process Development and Manufacturing: A Case Study Using Paracetamol".
Year(s) Of Engagement Activity 2016
 
Description Flexible Manufacturing Case Study 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Our Innovate UK/EPSRC collaborative project provided a case study for the Flexible Manufacturing Special Interest Group Report on the current innovation landscape provided in October 2014.


"This report has been the main driver behind InnovateUK's new £6million call in the Flexible Manufacturing Competition for funding.
The case study: Advanced Process Control (APC) For Continuous Processing is featured on p27. "
Year(s) Of Engagement Activity 2014
 
Description GSK CEO Visit 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Sir Andrew Witty, chief executive officer (CEO) of GlaxoSmithKline visited the CMAC National Facility in February 2016. There were presentations and discussions on the research, skills, facilities and key industry translation activities followed by a tour of the facilities. He was accompanied by the Principal of University of Strathclyde Professor Sir Jim McDonald, Scottish Enterprise and senior representatives from GSK. Sir Andrew and his team were very complimentary and were impressed by the range of activities and people they met. He commented that CMAC was an exemplar of critical mass research activities.
Year(s) Of Engagement Activity 2016
 
Description I2APM Symposium and Training Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact The first I2APM Symposium and Training Day took place in TIC hosted by CMAC on 30th Nov-1st December 2016. The event was a wonderful opportunity to get to know international colleagues and to initiate new collaborations. There are 14 proposals for researcher exchanges to take place between the three centres in future as a result of this event.
For followers of social media the I2APM now has a twitter account @I2APM
Year(s) Of Engagement Activity 2016
 
Description ICMR 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact ICMR 2015: Murray Robertson (RA in ICT CMAC, Strathclyde) presented at the 13th International Conference on Manufacturing Research (ICMR) 2015, 8-10 September 2015 at the University of Bath. The title is "Developing a Data Acquisition, Analysis and Reporting System For An Academic Laboratory".


Dissemination of CMAC research
Year(s) Of Engagement Activity 2015
URL http://epc.ac.uk/events/13th-international-conference-on-manufacturing-research-icmr2015/
 
Description IChemE GlobalResearch Award 2015 shortlisted 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact IChemE GlobalResearch Award shortlisted in Research Project category for Make-to-order Product Properties - Perceptive Engineering Ltd; University of Strathclyde; Centre For Process Innovation; AstraZeneca, UK
A new generation of continuous reactors is coming onto the market, aimed at traditionally batch-manufactured high-value, low-volume processes. These units have a high level of operational flexibility, enabling a single reactor to manufacture multiple products over a wide range of operating conditions. The MOPPs project developed an automation system to automatically derive the maximum possible benefits from these units. Analytical modelling tools and control strategies can be transferred rapidly between reactors, allowing agile, short-run and multi-product manufacture in sectors such as such as next-gen pharmaceuticals and speciality chemicals. Demonstrator Systems were developed for both flow chemistry and continuous crystallisation systems.
https://www.icheme.org/events/awards/awards%202015/global/shortlists/research%20project.aspx
Year(s) Of Engagement Activity 2015
 
Description ISPE Announces 2016 Category Winners: Facility of the Year Awards. Honorable Mention for CMAC 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact ISPE Announces 2016 Category Winners: Facility of the Year Awards. Honorable Mention: University of Strathclyde has received honorable mention for its Centre for Continuous Manufacturing and Crystallisation (CMAC) in Glasgow, Scotland. The collaboration between industry, academia and government represents the future of pharmaceutical manufacturing and supply chain R&D framework.
Year(s) Of Engagement Activity 2016
URL http://www.wtrf.com/story/31110257/ispe-announces-2016-facility-of-the-year-award-winners
 
Description Industry Studies Association (ISA) Conference 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Harrington, T.S. 'The future Pharmaceutical industry landscape: emergent therapies, technologies and supply networks', Industry Studies Association (ISA) Conference, Kansas City MO


Dissemination of CMAC research
Year(s) Of Engagement Activity 2015
URL http://www.industrystudiesconference.org/conference/2
 
Description International Workshop Puerto Rico 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact CMAC were requested by EPSRC and NSF to host a 2-day workshop in Puerto Rico with the purpose of identifying opportunities for internationally leading research collaboration to advance current practices in continuous manufacturing of pharmaceuticals via new, sustained joint activity.


The international team comprising members of CMAC and C-SOPS and global industry developed a shared vision to establish an International Institute for Advanced Pharmaceutical Manufacturing.
Year(s) Of Engagement Activity 2014
 
Description Invited Exhibitor at TIC Opening Event 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact CMAC researchers present at opening event for new TIC building which will house the new National Facility. We had a demo stand to showcase CMAC research to a non-academic audience.


CMAC team met the First Minister of Scotland and shared the CMAC vision for research
Year(s) Of Engagement Activity 2014
 
Description Invited speakers at Monitoring and controlling polymorphic form of pharmaceuticals during continuous crystallisation, APS, Hatfield, 2014. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact McGlone, T.; Briggs, N., Dunn, J., Florence, A. J.,
Invited speakers at Monitoring and controlling polymorphic form of pharmaceuticals during continuous crystallisation, APS, Hatfield, 2014.


Dissemination of CMAC research to community
Year(s) Of Engagement Activity 2014
 
Description Larson Crystallisation Workshop 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Ni, X. Continuous manufacturing and crystallisation, the Larson Crystallisation Workshop, Indianapolis, USA, 7-9th October 2013.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2013
 
Description Member of Chemical Innovation Knowledge Transfer Network (CIKTN) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Participants in your research or patient groups
Results and Impact Professor Alastair Florence was invited to join the board of Chemical Innovation Knowledge Transfer Network (CIKTN) . Awarding Body - Chemical Innovation Knowledge Transfer Network, Name of Scheme - Board
Year(s) Of Engagement Activity 2013
 
Description Member of the Scottish Technology Advisory Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Participants in your research or patient groups
Results and Impact Craig Johnston was appointed to the Scottish Technology Advisory Group . Awarding Body - Scottish Technology Advisory Group, Name of Scheme - Board
Year(s) Of Engagement Activity 2013
 
Description NTU - Strathclyde Collaboration Visit 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Supporters
Results and Impact "NTU - Strathclyde Collaboration Visit
The Collaboration between CMAC (Strathclyde) and SCBE (Nayang Technological University - NTU) was initiated in 2012 and there are now 5 PhD researchers in place across the University of Strathclyde and NTU Singapore.

The collaboration was strengthened a visit by VIPs from Nanyang Techological University. The NTU Provost Freddy Boey, NTU Deputy Provost Tsuhan Chen, NTU Dean of Engineering Chan Hin Kam and Christina Tong, Special Advisor, President's Office; Member of Singapore Pharmacy Council toured the CMAC Facilities in TIC with CMAC Director Professor Alastair Florence

In September 2016 a Symposium event was hosted at Strathclyde by Strathclyde Principle Sir Jim McDonald and NTU President Professor Bertil Andersson. Workshop Outputs consisted of updating future research funding plans and scoping projects for future researcher exchanges. There were updates from both centres on progress of current projects and discussions on future plans including demonstrating proof of concept studies relating to real industry challenges.
A researcher placement scheme is in operation between the two Universities and the first placement has recently been completed, and another is in progress with more planned for 2017.
"
Year(s) Of Engagement Activity 2016
 
Description NiCE-MSI Open Day, NPL 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact "NiCE-MSI Open Day, NPL Teddington
Presentation by Prof Alastair Florence ""Measuring Medicines: Understanding and control on Continuous Manufacturing and Crystallisation"""
Year(s) Of Engagement Activity 2016
 
Description Nucleation -a transition state to the directed assembly of materials Faraday Discussion. 30 March - 1 April 2015, Leeds, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Prof Joop Ter Horst and Dr Martin Ward of CMAC were speakers at Nucleation -a transition state to the directed assembly of materials
Faraday Discussion. 30 March - 1 April 2015, Leeds, UK

Dissemination of CMAC research to Scientific community
Year(s) Of Engagement Activity 2015
URL http://www.rsc.org/images/031425_148%20x%20105%20EVENTS_A6%20postcard_WEB_tcm18-241766.pdf
 
Description Pint of Science 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Professor Chick Wilson and researcher Lauren Agnew (Bath) recently took some of our work along to the Annual Pint of Science Festival. Lauren led the atoms to galaxies night, with CMAC's Chick Wilson being one of the speakers. Chick delivered a public talk on "Disaster Prevention in the Molecular World" which showed how research such as that carried out in CMAC attempts to secure product integrity in pharmaceuticals and other materials, all the way from molecules to manufacture. May 18-20, 2015.

Outreach Activity
Year(s) Of Engagement Activity 2015
URL https://pintofscience.com/
 
Description Presentation at NTREM 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Explosives at Extreme Conditions: Polymorphism of 2,4-dinitroanisole presentation by P. Coster at The 17th Seminar of New Trends in Research of Energetic Materials (NTREM 2014) in Pardubice, Czech Republic, 2014.


Dissemination of CMAC research to the international research community
Year(s) Of Engagement Activity 2014
 
Description Presentation at 1st Northern Postgraduate Chemical Engineering Conference, 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Cronin, L.: Networking Complex Chemical Systems. In 1st Northern Postgraduate Chemical Engineering Conference: Newcastle, 2013.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2013
 
Description Presentation at 1st Winter Process Chemistry Conference 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact McGlone, T.; Florence, A. J.; Briggs, N.: Crystallisation; control of solid form and continuous processing. In 1st Winter Process Chemistry Conference: Leeds, 2013.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2013
 
Description Presentation at 2nd Flow Chem Asia Conference, 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact McGlone, T.; Florence, A. J.; Briggs, N.: Development of Continuous Crystallisation for Particle Control. In 2nd Flow Chem Asia Conference: Singapore, 2013.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2013
 
Description Presentation at 45th BACG, UK, 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Presentation: Development of continuous crystallisation processes of pharmaceutical compounds to achieve better control over particle attributes. (Jawor-Baczynska, A.) 45th BACG conference, Leeds, UK, 13-15 July 2014.


Dissemination of CMAC research to research community
Year(s) Of Engagement Activity 2014
 
Description Presentation at APACT 2012 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Palmer, L.; Littlejohn, D.; Nordon, A.; Sefcik, J.; Florence, A.; Zhao, L.: Monitoring continuous crystallisation in oscillatory baffled reactors by non-invasive Raman spectrometry. APACT 12, Newcastle, UK, 2012.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2012
 
Description Presentation at APS 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Srai, J. S.; Harrington, T.; Alinaghian, L.: End to End Pharma Supply Chains. In Association of Pharmaceutical Sciences (APS): Edinburgh, UK, 2013.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2013
 
Description Presentation at APS PharmSci 8th - 10th September 2014, University of Hertfordshire, Hatfield 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Novel Paracetamol formulations produced by Hot-Melt Extrusion Authors: L. Martinez-Marcos, D.A. Lamprou, G.W. Halbert
Presented by L. Martinez-Marcos

Dissemination of CMAC research to the UK community
Year(s) Of Engagement Activity 2014
 
Description Presentation at Annual World Congress of Advanced Materials 2012 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Ni, XW.: Flow chemistry technology handling solids including crystallisation. BIT Annual World Congress of Advanced Materials 2012, Beijing, China, 7th June 2012.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2012
 
Description Presentation at BACG 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Florence, A. F.:Continuous Crystallisation for Control of Pharmaceutical Products. In The 44th Annual Conference of the BACG, Manchester, 2013.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2013
 
Description Presentation at BCA Industrial Group 2012 Autumn Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Florence, A. F.:Crystallisation: Friend or Foe. In BCA Industrial Group 2012 Autumn Meeting, Birmingham, 2012.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2012
 
Description Presentation at BP Postgraduate Symposium, University of Bath, 12th-13th May 2014. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Wittering, K. presentation: Towards Multi-component Crystallisation Within the Continuous Flow Environment. The BP Postgraduate Symposium, University of Bath, 12th-13th May 2014.


Dissemination of CMAC research to postagraduate community
Year(s) Of Engagement Activity 2014
 
Description Presentation at Centre for Sustainable Chemical Technologies 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact "Wilson, C.C., Developing sustainable production of elusive solid forms by templating continuous crystallisation, Centre for Sustainable Chemical Technologies, Bath, September 2013.
"


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2013
 
Description Presentation at Conference on Frontiers in Organic Synthesis, 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Florence, A. F.:Continuous Crystallisation for Control of Pharmaceutical Products. In Frost 4th Conference on Frontiers in Organic Synthesis Technology, Budapest, 2013.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2013
 
Description Presentation at Continuous Flow Technology in Industry, York, 2012 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Florence, A. F.: In Continuous Flow Technology in Industry, York, 2012.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2012
 
Description Presentation at Continuous Processing Conference, 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Ni, X. Flow chemistry technology, Exploring Continuous Processing Conference, Alderley Conference Centre, Cheshire, 24th April 2013.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2013
 
Description Presentation at Directed Assembly Network Meeting, Royal Society, London, March 2014. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Presentation: Wilson, C.C., Directed self-assembly chemistry and crystallisation of advanced molecular solid forms under flow, Directed Assembly Network Meeting, Royal Society, London, March 2014.



Dissemination of CMAC research to UK community
Year(s) Of Engagement Activity 2014
 
Description Presentation at ECM-28, 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact "Wilson, C.C., Multi-Component Molecular materials: Design, Properties, Crystallisation, Manufacture, European Crystallographic Meeting, ECM-28, Warwick, August 2013.
"


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2013
 
Description Presentation at European Process Intensification Conference, 2012 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Ni, X. Flow chemistry technology handling solids including crystallisation, European Process Intensification Conference, Geleen, the Netherlands, 27-28th September 2012.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2012
 
Description Presentation at FACSS 2011 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Littlejohn, D.; Palmer, L.; Nordon, A.; Sefcik, J.; Florence, A.; Zhao, L.: In situ monitoring of crystallisation processes in oscillatory baffled reactors by non-invasive Raman spectrometry. FACSS 2011, Reno, USA, 2011.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2011
 
Description Presentation at ISPE Annual Meeting 2011 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Ni, XW.: Continuous manufacturing and crystallisation. The ISPE Annual Meeting, Dallas, USA, 7-9th November 2011.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2011
 
Description Presentation at International Conference on Crystal Growth and Epitaxy 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Jawor-Baczynska, A.; Sefcik, J.: Development of continuous crystallisation processes of pharmaceutical compounds to achieve better control over final product attributes. In 17th International Conference on Crystal Growth and Epitaxy: Warsaw, Poland, 2013.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2013
 
Description Presentation at International Conference on Neutron Scattering 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Pulham, C.R. Putting the squeeze on energetic materials - high-pressure neutron diffraction studies of a melt-cast explosive. International Conference on Neutron Scattering, Edinburgh, July 2013.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2013
 
Description Presentation at National Chemical Laboratory, Pune 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Pulham, C.R. Continuous Crystallisation and Sustainable Chemistry, National Chemical Laboratory, Pune, India, February 2013.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2013
 
Description Presentation at Pharma Manufacturing Leaders Forum, 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Bititci, U.: Strategic Supply Chain Opportunities of continuous manufacturing. In Pharma Manufacturing Leaders Forum: Bratislava, Slovakia, 2013.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2012
 
Description Presentation at SCIX 2012 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Littlejohn, D.; Palmer, L.; Logue, D.; Briggs, N.; Nordon, A.; Florence, A.; Sefcik, J.; Zhao, L.; Raval, V.: Assessment of continuous reactor technologies for the cooling crystallisation of L-Glutamic acid. SCIX 2012, Kansas City, USA, 2012.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2012
 
Description Presentation at Van't Hoff Institute for Molecular Sciences, January 2012 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Ni, X. Flow chemistry technology handling solids including crystallisation, Van't Hoff Institute for Molecular Sciences, University of Amsterdam, the Netherlands, 17th January 2012.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2012
 
Description Presentation at the 25th Annual Production and Operations Management Society (POMS) Conference in May 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Presentation: Srai, J. S.: Product development and manufacturing process development in the pharmaceutical industry
at the 25th Annual Production and Operations Management Society (POMS) Conference in May 2014.


Dissemination of CMAC research to international community
Year(s) Of Engagement Activity 2014
 
Description Presentation at the autumn meeting of the Industrial Group of the British Crystallographic Association, held in London at the Royal Institution of Great Britain. 12th November 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Presentation by CMAC researcher Wittering K E
X-ray Diffraction as a Fundamental Tool in Development and Understanding of Continuous Multi-component Crystallisation

Dissemination of CMAC research to UK research community
Year(s) Of Engagement Activity 2014
 
Description Presentations at AIChE 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Schacht, U.: From batch to continuous crystallisation: nucleation and growth under various flow conditions. The American Institute of Chemical Engineers (AIChE) Conference in San Francisco, 2013.

Jawor-Baczynska, A.: Populations and size distributions of solute-rich mesoscale structures in aqueous amino acid solutions and their role in crystal nucleation. The American Institute of Chemical Engineers (AIChE) Conference in San Francisco, 2013.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2013
 
Description Presentations at ISIC, Toullouse, September 2014. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Opulations and size distributions of solute-rich mesoscale structures in aqueous amino acid solutions and their role in crystal nucleation. presentation by Jawor-Baczynska, A. at 19th International Symposium on Industrial Crystallization (ISIC), Toullouse, 16-19th September 2014.
And
Presentation by Sefcik, J.: 19th International Symposium on Industrial Crystallization (ISIC), Toullouse, 16-19th September 2014.

Dissemination of CMAC research results to international research community
Year(s) Of Engagement Activity 2014
 
Description Presentations at RSC Symposium 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Srai, J. S.: Technologies on the End-to-end Pharmaceutical Supply Chain. In RSC Symposium 2013: Practical Continuous Flow Technology, 2013.

Florence, A. J.: Development of a Continuous Crystallisation in an Oscillatory Baffled Reactor. In The Royal Society of Chemistry Symposium 2013


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2013
 
Description Presentations at SCIX 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Littlejohn, D.; Nordon, A.; Palmer, L.: Monitoring of continuous crystallization using non-invasive Raman and acoustic emission spectroscopies. SCIX Milwaukee, USA, 2013.

Nordon, A.; Logue, D.; Wurker, L.; Littlejohn, D.; Hamilton P.: Non-Invasive Monitoring of Powder Drying by Broadband Acoustic Emission Spectrometry in Comparison with Spectroscopic Techniques. SCIX Milwaukee, USA, 2013.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2013
 
Description Presentations at The British Crystallographic Association Spring Meeting, Loughborough University, 7-10th April 2014. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Presention:Wittering, K. Towards Continuous-flow Crystallisation of Multi-component Systems of Pyrazine Carboxamide: A World Health Organisation (WHO) Essential Medicinal Compound for Tuberculosis Treatment. The British Crystallographic Association Spring Meeting, Loughborough University, 7-10th April 2014.
Invited Speaker Presentation: Pulham, C.R.; Crystal engineering of energetic materials - a step change in the design of safer explosives and propellants?
at British Crystallographic Association, Spring Meeting, April 2014.

Dissemination of CMAC research to the UK research community
Year(s) Of Engagement Activity 2014
 
Description Press Nov 2016 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact CMAC has been in the press in Nov 2016, with CMAC Industrial Director Craig Johnston's interview by Gareth MacDonald posted on in- pharmatechnologist.com focusing on adoption of continuous manufacturing in Pharmaceuticals, and a report on the Powerhouse events in conjunction with PwC featuring an article by Craig on how our work in CMAC can help grow the life sciences business sector in Scotland.
Year(s) Of Engagement Activity 2016
URL http://www.engage-sbs.com/life-sciences-a-key-sector-for-the-glasgow-economy/
 
Description RCPE Director Visits CMAC 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other audiences
Results and Impact RCPE Director Visits CMAC
On Wednesday 9th December, CMAC hosted a visit from Massimo Bresciani, Director of Scientific Operations at RCPE, Austria. RCPE and CMAC, together with C-SOPS in the US, form the International Institute for Advanced Pharmaceutical Manufacturing (I2APM) - a research and educational partnership with the goal of advancing the science and technology of integrated primary and secondary continuous manufacturing of pharmaceutical products. Massimo met with Alastair Florence, Craig Johnston, Andrea Johnston and Claire Ordoyno, in what proved to be a very productive series of meetings.
Year(s) Of Engagement Activity 2015
 
Description RSC Spectroscopy in a Suitcase 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact EPSRC Centre Researchers involved in interactive sessions delivered to schools.

These visits can be booked at any time.
Year(s) Of Engagement Activity 2012
 
Description Roadshow on Structure and Properties of Energetic Materials 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact EPSRC Academic Colin Pulham presented.

Presenting at the 2013 Orkney Science Festival.
Year(s) Of Engagement Activity 2013
 
Description Royal Opening of TIC 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact On Friday 3rd July the new Technology and Innovation Centre (TIC) at University of Strathclyde was opened by Her Majesty the Queen. During her visit to TIC the Queen toured the CMAC laboratories with Academic Director Professor Alastair Florence, Industry Director Craig Johnston and Chair of CMAC Board Dr Clive Badman OBE (GSK). The Queen met with CMAC Tier 1 Partners, Academics and Reseachers and was shown some of the new equipment that has been purchased using the RPIF Award.
We have had very positive feedback about the visit.



Engagement with Tier 1 partners, and visit highly visible in the press.
Year(s) Of Engagement Activity 2015
URL http://www.strath.ac.uk/whystrathclyde/thequeenopenstechnologyinnovationcentre/
 
Description Seminar - André de Vries 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact André de Vries (DSM Chemical Technology) gave a talk to CMAC at Strathclyde entitled "3D-printed Metal Flow Reactors; Design, Production & Applications" as CMAC's guest at University of Strathclyde on 12th Dec 2016.  CMAC's Dr Ian Houson chaired the seminar.
Year(s) Of Engagement Activity 2016
 
Description Seminar - Dr Harris Makatsoris 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Dr Harris Makatsoris of Cranfield University visited Dr Andrea Johnston and CMAC colleagues in TIC on 27th April 2016 and as part of his visit he delivered a seminar: "Robot chemists, artificial creativity and self-evolving chemical systems: the evolution of science or science fiction?"
Year(s) Of Engagement Activity 2016
 
Description Seminar - Dr Steven Ferguson 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Dr Steven Ferguson had recently taken up a position as a Lecturer in the School of Chemical and Bioprocess Engineering, at University College Dublin and visited CMAC's Prof Jan Sefcik on 12th May 2016. As part of the visit Steven gave a seminar entitled "Continuous Crystallization of Active Pharmaceutical Ingredients".
Year(s) Of Engagement Activity 2016
 
Description Seminar Bayer 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact "Dr Wolfgang Beckmann, Bayer
Thursday 28th January 2016, 12pm Thomas Graham 223
'Purification of Organic Molecules by Crystallization - Some Considerations following Case Studies'
Dr Beckmann is Senior Expert at Bayer Technologies. He studied Chemical Engineering and Physical Chemistry in Germany and the US. He spent one year as a Postdoctoral Fellow in Marseille and has spent the last 20 years working at Bayer developing crystallization processes for pharmaceutical compounds."
Year(s) Of Engagement Activity 2016
 
Description Seminar Seimens 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact "CMAC Seminar @ Strathclyde - Alan Norbury, Seimens
Tuesday 19th January 2016, 11am SIPBS HW 112-114
'The Factory of the Future - Industry 4.0'
Alan Norbury is the Central Technology Officer for Siemens industrial activities - a leading global supplier of industrial plant and software, manufacturing automation and drive technologies to industrial customers across the UK and Ireland."
Year(s) Of Engagement Activity 2016
 
Description Siemens CEO Visits TIC 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Juergen Maier, CEO of Siemens UK, visited the Technology and Innovation Centre (TIC) as part of a University of Strathclyde wide event. During his visit in March 2016 he toured the EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC). During Juergen's visit he reaffirmed Siemens commitment to supporting CMAC to the Principal Prof Sir Jim McDonald. The visit included participation from Phil Shering - AstraZeneca Associate Engineering Director; Juergen Maier; Prof Sir Jim McDonald, Principal; Craig Johnston, CMAC Industrial Director; and Prof Alastair Florence, CMAC Director.
Siemens plc are now members of CMAC alongside established Tier 1 and Tier 2 members, which also include Siemens approved Solution Partner - Booth Welsh.
Juergen presented to a large audience in the Main Auditorium, and presented a fascinating talk in industrial history, the current status and a future vision for industry in the UK and Scotland entitled "Can Scotland seed a new Industrial Revolution?".
Year(s) Of Engagement Activity 2016
 
Description Summer School on Crystal Nucleation 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact CMAC's Prof Joop ter Horst hosted the summer school on crystal nucleation held June 20-24 at the University of Strathclyde in Glasgow.
Year(s) Of Engagement Activity 2016
 
Description Talk at ECCG5 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Dissemination of CMAC research
Year(s) Of Engagement Activity 2015
URL http://www.imem.cnr.it/eccg5/
 
Description The Molecular Odyssey 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact EPSRC Centre Academic involved in outreach acivities.
Year(s) Of Engagement Activity 2011
 
Description UK Manufacturing Reveiw 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact CMAC in UK Manufacturing Review
CMAC Assistant Centre Manager Helen Feilden attended the launch of the UK Manufacturing Review 2015-2016. The publication is a 250+page high quality book, a "super-magazine", written by expert journalists across industry sectors, that summarises the status of the manufacturing, engineering and technology sectors in 2015. CMAC was featured on p220 of the Review as well as being mentioned in the "Road to 2016" infographic on p18 and the section on Pharmaceuticals on p43 of the book. https://hvm.catapult.org.uk/news-events-gallery/news/uk-manufacturing-review-2015-2016-launched/
Year(s) Of Engagement Activity 2015
URL https://hvm.catapult.org.uk/news-events-gallery/news/uk-manufacturing-review-2015-2016-launched/
 
Description UK/USA/CA/AUS Technical Cooperation Program (TTCP), Indian Head Naval Surface Warfare Center, March 2014. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Pulham, C.R. & Coster, P.L. Crystallisation studies of 2.4-dinitroanisole (DNAN). UK/USA/CA/AUS Technical Cooperation Program (TTCP), Indian Head Naval Surface Warfare Center, March 2014.


Dissemination of CMAC research to community
Year(s) Of Engagement Activity 2014
 
Description Visit by Professor San Kiang, C-SOPS 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact "Visit by Professor San Kiang, C-SOPS
In May 2016, CMAC hosted Professor San Kiang from C-SOPS. Prof. Kiang met with staff to discuss I2APM collaborative projects and was also shown round the CMAC laboratories and equipment. Prof. Kiang also gave a highly informative seminar for CMAC staff and students entitled "The Role of Particle Engineering in Designing Pharmaceutical Particles and Pharmaceutical Composite Material (PCM)".
This week (24-25 May 2016) CMAC were delighted to host Professor San Kiang from the Center for Structured Organic Particulate Systems (C-SOPS) in the US. CMAC and C-SOPS, along with the Research Centre Pharmaceutical Engineering (RCPE) in Austria, have formed the International Institute for Advanced Pharmaceutical Manufacturing (I2APM) - a research and educational partnership with the goal of advancing the science and technology of integrated primary and secondary continuous manufacturing of pharmaceutical products.
Prof. Kiang met with Cameron Brown, Andrea Johnston, Blair Johnston, Jan Sefcik and Claire Ordoyno to discuss I2APM collaborative projects, and visited the CMAC laboratories and equipment with Thomas McGlone and John Robertson.
Prof. Kiang has thirty-five years of experience in pharmaceutical development and technology transfer in Bristol-Myers Squibb, and he shared some of this with CMAC staff and students in a highly informative seminar entitled "The role of particle engineering in designing pharmaceutical particles and pharmaceutical composite material (PCM)".

"
Year(s) Of Engagement Activity 2016
 
Description White Papers from International Symposium on Continuous Manufacturing of Pharmaceuticals published online 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact On 20th-21st May 2014, CMAC co-hosted the first International Symposium on Continuous Manufacturing of Pharmaceuticals at MIT, US. This prestigious event was attended by world leaders in continuous processing, with pharmaceutical end users, suppliers, regulators and academics who discussed accelerating adoption of continuous manufacturing for both small molecules and biological products.


The key outputs of the meeting were 8 white papers which are due to be published shortly the Journal of Pharmaceutical Science. The final drafts can be found on the website.
Year(s) Of Engagement Activity 2014
URL https://iscmp.mit.edu/white-papers
 
Description Workshop: Molecular Materials - from fundamentals to applications 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This early career researcher scientific workshop was sponsored by the British Council and the RSC and co-organised by CMAC PI Prof. Colin Pulham and Prof. Elena Boldyreva (Novosibirsk University). 3 CMAC researchers also attended the workshop



Esteemed colleagues in our field including Prof. Sally Price (CPOSS), Prof Joel Bernstein and Prof Bill Jones (CMAC Advisory Board) were in attendance.
http://www.iucr.org/calendar/events/topics/general/name-molecular-materials-from-fundamentals-to-applications"
Year(s) Of Engagement Activity 2015
 
Description presentation at APACT 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Palmer, L.; Littlejohn, D.; Nordon, A.: Florence, A.: Sefcik, J. Non-invasive monitoring of continuous crystallisation. APACT 13, Chester, UK, 2013.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2013
 
Description presentation at SCI Process Development Symposium 2011 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Ni, X. Flow chemistry technology handling solids including crystallisation", the 29th Society of Chemical Industry (SCI) Process Development Symposium, Churchill College, Cambridge University, Cambridge, 7-9th December 2011.


Dissemination of CMAC research to academic community
Year(s) Of Engagement Activity 2011
 
Description press - Britest are New Tier 2 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Our new Tier 2 partner Britest shared a press release about joining CMAC. You can read it at https://www.britest.co.uk/news/cmac_membership/
Year(s) Of Engagement Activity 2016
URL https://www.britest.co.uk/news/cmac_membership/