Protein-Protein Interaction Inhibitors: From Design and Synthesis, Through Biophysics to Cell Permeable Inhibitors

Lead Research Organisation: University of Leeds
Department Name: Sch of Chemistry


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Description Protein-protein interactions control all cellular functions and so represent important targets for therapeutic intervention and healthy living. Despite this, the study of protein-protein interactions and the development of drugs to modulate their function is considered an outstanding academic and industrial problem.
a national network of interconnected researchers in the protein-protein interactions remit together with a landscape document outlining capability, opportunities and future challenges was produced
Exploitation Route new responsive mode grant applications are being prepared and submitted as a consequence of challenges and opportunities highlighted through the network discussions. The activities of the network were central in defining a new research programme now funded through the EPSRC programme grant scheme.
Sectors Chemicals,Healthcare

Description The Protein-Protein Interactions Network (PPI-Net) is a National Network for Protein-Protein Interactions (PPI) which starting April 2011. The Networkwas jointly funded by Engineering and Physical Science Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (BBSRC), and the Medical Research Council (MRC) between April 2011 - March 2013, with a no-cost extension until September 2013. The funding support the development of this national network, a national and an international conference alongside various placements, discussion and working groups. In the course of the funded period, PPI-net produced a community landscape document out-ling capacity, capability and opportunities in this area. Legacy outputs include a compound collection held at Leeds university and an annual young researchers conferece
First Year Of Impact 2011
Sector Chemicals,Healthcare,Pharmaceuticals and Medical Biotechnology
Impact Types Societal

Description EPSRC Programme Grant
Amount £3,400,000 (GBP)
Funding ID EP/N013573/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 02/2016 
End 01/2021