Sculpting Dynamic Amphiphilic Structures

Lead Research Organisation: Imperial College London
Department Name: Dept of Chemistry

Abstract

Biomembranes lie at the heart of most biological function, and lipid membranes are increasingly finding a wide range of novel applications in biotechnology and nanomedicine. Such self-assembled amphiphilic interfaces can adopt an astonishing range of complex shapes and liquid-crystalline structures ordered in 1, 2 or 3 dimensions, over length scales stretching from 2 - 3 nanometres, to microns. Gaining an understanding at a molecular level of how interface structure, ordering, dynamics and micromechanics depend upon chemical structure and composition, and thermodynamic variables such as temperature, hydration, and pressure, is the key to learning how we can manipulate such self-assembled soft interfaces to create novel and useful structures and new technologies, and this is the main aim of this Programme.

We have identified three key underpinning basic science challenges: 1) asymmetry; 2) patterning; 3) curvature, long-range organisation and symmetry. There are four main aspects underlying these challenges which we consider are of crucial importance: i) compositional asymmetry and dynamics of amphiphile flip-flop across bilayers; ii) lateral segregation, line tension and microdomain formation; iii) membrane curvature and curvature elasticity; iv) charge and dipolar interactions between lipid headgroups. Furthermore, there is a complicated coupling between all of these four aspects, and this is where we will focus much of our attention.

We have assembled a team of five leading UK University research groups, spanning Chemistry, Physics and Biophysics. The groups have complementary expertise covering laboratory-based and synchrotron time-resolved X-ray diffraction, neutron scattering, solid-state nuclear magnetic resonance, calorimetry, biomolecular force microscopy, Langmuir trough and microfluidics technologies, linear and non-linear spectroscopies, atomic force microscopy, spectroscopic and optical imaging, optical tweezers, microrheology, and theory. These approaches will be used to attack different inter-related aspects of the three key basic science challenges. We will ensure an efficient translation and synthesis of all of the findings, by a tightly- regulated management structure, and by regular meetings and staff exchanges between the five research groups.

Building on the engineering rules and technologies developed previously in the programme, we will integrate the earlier work to develop lipid structures into active lipid systems such as: self-encapsulated droplet interface bilayer networks in water; patterned asymmetric vesicles of defined size: coupling microfluidics with smart droplet microtools; phospholipid phases and vesicles in thermal gradients.

We will then use this knowledge to develop three demonstration systems:

i) Artificial Organelles. The development of artificial organelle machines which mimic some of the remarkable functions and properties of biology will lead to new approaches for personalized healthcare.

ii) Rapid drug-membrane binding screen. A compartmentalised, rapid drug screening device will allow parallel measurements of drug interactions with a number of artificial plasma membrane mimics (PMMs) formed by an array of parallel droplet interface bilayer or vesicle networks.

iii) In-Cubo Crystallization of Large Membrane Proteins. Learning how to swell lipid cubic phases will unlock our ability to construct cubic scaffolds with unit cell dimensions of the order of tens or hundreds of nanometres, allowing incorporation of large membrane proteins (>50kD), which are major drug targets for the pharmaceutical industry.

Further biological and biotechnological applications will be developed during the course of the Programme by the current Investigators and a wider group of industrial and academic collaborators, who will be brought into the Programme as appropriate.

Planned Impact

Our ambition within this Programme grant is to exploit the emerging field of molecular membrane engineering, by designing and constructing new biologically-inspired parts, devices and systems with user-defined levels of asymmetry, patterning and curvature. This will revolutionise the design and fabrication of smart, soft materials based on the lipid bilayer as the basic structural motif, with morphologies spanning the nano to micron lengthscale, and dynamics controlled over a wide range of timescales. In the longer term this will lead to a paradigm shift in areas such as nanomedicine, bioelectronics, biological computing devices and synthetic cells.

To achieve this we will bring together five leading UK research groups to investigate experimentally and theoretically the rules underpinning the self-assembly, ordering and dynamics of amphiphilic systems.

This knowledge will then be exploited:
i) to develop quantitative engineering rules for construction of 2-D and 3-D membrane-based structures with targeted asymmetry, patterning and curvature, focussing initially on purely lipid-based systems;

ii) to design self-assembled, fluid, amphiphilic systems with useful functional properties;

iii) to develop demonstrate applications, such as artificial organelles, high-throughput screens for drug discovery, and swollen cubic phases for membrane protein crystallisation.

We plan to invite companies with interests in these areas to participate by funding Industrial PhD Students from year 3 onwards to develop the applications, and to help embed the knowledge gained within an industrial context. We will spend £10k from our own resources on direct commercialisation activities, led by the ICB and the PM. They, together with the consortium, will:

a) network with relevant TSB Knowledge Transfer Networks and other industrial networks that may have an interest in these technologies;

b) develop Outline Concept Specifications documents as a starting point for discussions with ptential users and developers of the technologies;

c) form an Industry Consortium. In the final year of the project, an Industrial Showcase event will be held at Durham.

As this project extends the current state-of-the art we expect to generate intellectual property with significant commercial value, and will protect it via established technology transfer organisations who will cover the patenting costs. A consortium agreement will govern the IP generated, and the Advisory Board will be bound by a confidentiality agreement.

We will organise a Workshop in year 3, with invitees from both academia and industry, and an International Meeting in year 5. We will embed public engagement activities within the Programme, such as the Royal Society's Summer Science Exhibition. We will highlight the field of self-assembled complex soft materials by making conference lectures freely available on iTunesU /YouTube and by a radio broadcast produced as part of the Imperial College Institute of Chemical Biology DTC Science Communication course. This will complement dissemination via websites, meetings, conferences and journal publications.

We expect the more junior Investigators and some of the post-doctoral researchers to become research leaders, either in industry or academia, within 5-10 years.

Publications

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Amjad OA (2017) Membrane Adhesion through Bridging by Multimeric Ligands. in Langmuir : the ACS journal of surfaces and colloids

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Aufderhorst-Roberts A (2017) Three-Phase Coexistence in Lipid Membranes. in Biophysical journal

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Aufderhorst-Roberts A (2018) Nanoscale mechanics of microgel particles. in Nanoscale

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Aufderhorst-Roberts, A (2016) The Need for Speed in InFocus Magazine

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Aufderhorst-Roberts, A (2015) The Venom that Packs a Punch for Cancer in Laboratory News

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Barlow NE (2016) Multiplexed droplet Interface bilayer formation. in Lab on a chip

 
Description We have carried out measurements - some for the first time - of:
a. Effect of membrane asymmetry on bilayer rigidity;
b. Effect of hydrostatic pressure on the mechanical properties of lipid bilayers;
c. Lifetime of membrane asymmetry using fluctuation analysis/SFG;
d. Interleaflet registration in phase-separated bilayers;
e. Coupling mobile ligands to soft membranes;
f. Soft pinning of liquid domains on caps;
g. Diffusion in lipid membranes;
h. Critical fluctuations in lipid mixtures by AFM.

We have developed:
a. Highly swollen cubic phases with dimensions comparable with those seen in Nature;
b. Vesicles with user defined size, asymmetry, cargo and biomolecule content;
c. Compartmentalised vesicles;
d. Extended 2-D/3-D droplet interface bilayer networks;
e. Compartmentalised extended lifetime multisomes;
f. Membrane encapsulated nanoparticles.

In terms of applications, we have developed:
a. Artificial cells capable of acting as micro-reactors, as well as performing in-situ drug synthesis, environmental sensing and smart delivery. The complexity of these systems is now such that we have transplanted spatially separated enzymatic pathways into artificial protocells;
b. High-throughput screens for drug discovery;
c. Studies of membrane translocation profiles for agrichemicals (Syngenta), PROTAC molecules (GSK plc) and hair additives (P&G) using droplet interface bilayer networks.
Exploitation Route By bringing together five world leading UK research groups, this Programme grant has pioneered a series of breakthroughs in the emerging field of molecular membrane engineering that have already supported 40 publications, 38 high profile international conferences, 33 oral and poster presentations, £20M+ in follow-on funding and 3 industrial collaborations. The successful development of quantitative engineering rules for the construction of 2-D and 3-D membrane-based structures with user defined levels of asymmetry, patterning and curvature has enabled us to extend the aims and ambitions of the project beyond proof of concept applications to include direct commercial exploitation. New collaborations with leading technology companies in the pharmaceutical (GSK plc), agri-tech (Syngenta) and personal care sectors (P&G) should led to the translation of the innovations from the Programme grant into the industrial sector.
Sectors Agriculture, Food and Drink,Chemicals,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

 
Description Many Outreach activities such as Imperial College Annual Festival
First Year Of Impact 2013
Sector Agriculture, Food and Drink,Chemicals,Education,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology
Impact Types Cultural,Societal

 
Description Biophysical Sciences Institute Summer undergraduate research studentship
Amount £2,000 (GBP)
Organisation Durham University 
Department Biophysical Sciences Institute
Sector Academic/University
Country United Kingdom
Start 07/2014 
End 09/2014
 
Description Leverhulme Doctoral Scholarship Programme
Amount £1,000,000 (GBP)
Organisation The Leverhulme Trust 
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 09/2021
 
Description Jonas Camillus Jeppesen - visiting international PhD student from the lab of Adam Simon Cohenson in Odense, Denmark 
Organisation University of Southern Denmark
Country Denmark 
Sector Academic/University 
PI Contribution Access to high-speed AFM, training, and techniques to study membrane dynamics with temperature control. Collaborator brought new samples and system well studied in their lab. The project was to study the early stages of domain nucleation in gel-phase binary lipid mixtures.
Collaborator Contribution None
Impact None-to-date, work still in progress
Start Year 2015
 
Description Crossing BioMembranes NET Conference, September 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact CBM (Crossing BioMembranes) NET Conference, September 2015.
Year(s) Of Engagement Activity 2015
 
Description Drug Disposition Symposium, Stevenage, June 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Drug Disposition Symposium, Stevenage, June 2015
Year(s) Of Engagement Activity 2015
 
Description Graduate school teaching, ICTP Trieste, July 2014 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Pietro Cicuta was involved in a hands-on graduate school in Trieste, Italy. This event increased discussion and knowledge transfer

Close interactions with graduate students and young faculty from developing countries helped to introduce new tools and techniques to the group, encouraging the development of scientific leaders in less developed countries
Year(s) Of Engagement Activity 2014
 
Description Halim Kusumaatmaja Invited Conference talk - 115th Statistical Mechanics Conference, Rutgers University, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Surveying Free Energy Landscapes: Applications to Continuum Soft Matter Systems, Rutgers University, USA
Year(s) Of Engagement Activity 2016
 
Description Halim Kusumaatmaja Invited Conference talk - : Fundamentals and Applications of Lipid Membrane Biophysics, London, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Continuum Theory of Lipid Membranes, London, UK
Year(s) Of Engagement Activity 2015
 
Description Halim Kusumaatmaja Invited Conference talk - Partial Order: Mathematics, Simulations and Applications, Institute for Pure and Applied Mathematics, UCLA, Los Angeles, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Surveying Free Energy Landscapes: Applications to Continuum Soft Matter Systems, UCLA, USA
Year(s) Of Engagement Activity 2016
 
Description Halim Kusumaatmaja Seminar talk - Department of Mathematics, Pennsylvania State University, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Wetting on Lipid Membranes, Pennsylvania, USA
Year(s) Of Engagement Activity 2016
 
Description Halim Kusumaatmaja Seminar talk - Department of Mathematics, University of York, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Membrane Phase Separation, York, UK
Year(s) Of Engagement Activity 2015
 
Description Halim Kusumaatmaja Seminar talk - Department of Physics, University of Oxford, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Phase Separation on Bicontinuous Cubic Membranes, Oxford, UK
Year(s) Of Engagement Activity 2016
 
Description Halim Kusumaatmaja Seminar talk - Institut Lumière Matière 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Phase Separation on Bicontinuous Cubic Membranes, Lyon, France
Year(s) Of Engagement Activity 2017
 
Description Halim Kusumaatmaja Seminar talk - State Key Laboratory of Polymer Physics and Chemistry, Changchun, China 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Curvature-Induced Phase Separation on Lipid Membranes, Changchun, China
Year(s) Of Engagement Activity 2015
 
Description Halim Kusumaatmaja Seminar talk - University of Rome Tor Vergata, Rome, Italy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Phase Separation on Bicontinuous Cubic Membranes, Rome, Italy
Year(s) Of Engagement Activity 2015
 
Description International Microfluidics Conference, London, October 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Microfluidics Conference, held in London over 2 days 20/21 October 2015.
Year(s) Of Engagement Activity 2015
 
Description Invited Lecture, Daejeon, March 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Halim Kusumaatmaja invited to present a talk at the British Council workshop on soft matter

Disseminating and sharing scientific knowledge to a wide audience, encouraging networking and future collaboration
Year(s) Of Engagement Activity 2014
 
Description Invited Plenary Lecture - Dynamics in Biological AFM, AFM Conference and Workshop, 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Requimte AFM Conference and Workshop, University of Porto, Portugal.
Year(s) Of Engagement Activity 2016
 
Description Invited lecture and workshop, Julich, October 2014 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Pietro Cicuta was invited to present a student lecture and workshop on the subject of particles interactions with membranes. The event engaged and sparked discussion and encouraged future collaborative activity

Engaged and sparked discussion, encouraged future collaborative activity
Year(s) Of Engagement Activity 2014
URL http://www.fz-juelich.de/ics/ics-2/EN/Leistungen/ConferencesAndWorkshops/Particles@Membranes/Venue/_...
 
Description Invited lecture, Austria, August 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Simon Connell invited to present a talk on Critical Membranes at the Bio-Nano summer school in Austria on the 14th August 2013.

Disseminating and sharing scientific knowledge to a wide audience, encouraging networking and future collaboration
Year(s) Of Engagement Activity 2013
 
Description Invited lecture, Austria, August 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Simon Connell presented a talk entitled 'Membrane Biophysics' at a Bio-Nano summer school in Austria in August 2014

Disseminating and sharing scientific knowledge to a wide audience, encouraging networking and future collaboration
Year(s) Of Engagement Activity 2014
 
Description Invited lecture, Coventry, September 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Simon Connell invited to present a talk on Fast Scan AFM dynamics in lipid membranes at the Bruker Nanoelectrical and Chemical workshop in Coventry on the 25th September 2014.

Disseminating and sharing scientific knowledge to a wide audience, encouraging networking and future collaboration
Year(s) Of Engagement Activity 2014
 
Description Invited lecture, Durham, August 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Halim Kusumaatmaja was invited to present a talk at the 2014 Energy Landscapes symposium and workshop hosted at Durham University.

Disseminating and sharing scientific knowledge to a wide audience, encouraging networking and future collaboration
Year(s) Of Engagement Activity 2014
 
Description Invited lecture, Durham, December 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact John Sanderson invited to a Cafe Scientifique talk about the chemistry of biological membranes. The talk increased awareness, engagement and discussion around this topic.

Knowledge transfer, networking and potential for future collaborative activity
Year(s) Of Engagement Activity 2013
 
Description Invited lecture, Goettingen, November 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Halim Kusumaatmaja was invited to present a talk at the Max Plank Institute for Dynamics and and Self Organisation in Goettingen in November 2014.

Disseminating and sharing scientific knowledge to a wide audience, encouraging networking and future collaboration
Year(s) Of Engagement Activity 2014
 
Description Invited lecture, London, September 2012 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Simon Connell invited to present a talk on Critical fluctuations in Lipid Membranes at Faraday Discussions 160, on 11th September 2012

Disseminating and sharing scientific knowledge to a wide audience, encouraging networking and future collaboration
Year(s) Of Engagement Activity 2012
 
Description Invited lecture, Lyon, September 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Halim Kusumaatmaja invited to present a talk on the influence of interfacial interactions on structural and rheological properties of confined liquids in Lyon in September 2013.

Disseminating and sharing scientific knowledge to a wide audience, encouraging networking and future collaboration
Year(s) Of Engagement Activity 2013
 
Description Invited lecture, Toronto, September 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact SImon Connell invited to present a talk on fast scan dynamics in lipid membranes at SPM on SPM in Toronto on the 5th September 2014

Disseminating and sharing scientific knowledge to a wide audience, encouraging networking and future collaboration
Year(s) Of Engagement Activity 2014
 
Description Invited lecture, York, March 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact John Seddon invited present a lecture at the Bruker Poster Prize Day at the Unviersity of York on the 20th March 2014.

Disseminating and sharing scientific knowledge to a wide audience, encouraging networking and future collaboration
Year(s) Of Engagement Activity 2014
 
Description Invited workshop contributor, London, February 2014 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact John Seddon was an invited participant at an EPSRC Physical Sciences leaders workshop at Imperial College London in February 2014.

Disseminating and sharing scientific knowledge to a wide audience, encouraging networking and future collaboration
Year(s) Of Engagement Activity 2014
 
Description John Sanderson, Chair - Membrane Peptides and Toxins 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Seminars: Membrane Peptides and Toxins (Session Chair, Biophysical Society Annual Meeting, New Orleans, February 11 - 15, 2017.
Year(s) Of Engagement Activity 2017
 
Description One Life: Science At The Interface, September 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact One Life: Science At The Interface, September 2015
Year(s) Of Engagement Activity 2015
 
Description Oral presentation, Lancaster, July 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Simon Connell presented a lecture at the EPSRC Physics of Life summer school at Lancaster University on 18th July 2014.

Disseminating and sharing scientific knowledge to a wide audience, encouraging networking and future collaboration
Year(s) Of Engagement Activity 2014
 
Description Oral presentation, Leeds, June 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Simon Connell presented a talk at the Royal Microscopy Society in Leeds on 26th June 2013. The talk encouraged further questions and debate

Disseminating and sharing scientific knowledge to a wide audience, encouraging networking and future collaboration.
Year(s) Of Engagement Activity 2013
 
Description Oral presentation, London, September 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Nicola McCarthy was invited to present a talk at the European High Pressure Research Group international conference in London.

Disseminating and sharing scientific knowledge to a wide audience, encouraging networking and future collaboration
Year(s) Of Engagement Activity 2013
 
Description Oral presentation, Manchester, October 2012 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Simon Connell presenteda talk on surface science of biologically important interfaces on the 18th October 2012. The event initiated further questions and discussion among the audience.

Disseminating and sharing scientific knowledge to a wide audience, encouraging networking and future collaboration.
Year(s) Of Engagement Activity 2014
 
Description Poster: Drug Lipidation in Membranes (full author list: Hannah M. Britt, Vian S. Ismail, Jackie A. Mosely and John M. Sanderson) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Poster: Drug Lipidation in Membranes, Biophysical Society Annual Meeting, Los Angeles, February 27-March 2, 2016
Year(s) Of Engagement Activity 2016
 
Description Poster: Drug Lipidation in Membranes (full author list: Hannah M. Britt, Vian S. Ismail, Jackie A. Mosely and John M. Sanderson) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Poster: Drug Lipidation in Membranes, Biophysical Society Annual Meeting, New Orleans, February 11 - 15, 2017
Year(s) Of Engagement Activity 2017
 
Description Simon Connell Conference talk - Critical Dynamics in supported membranes 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact 8th-10th December 2016 "Critical Dynamics in supported membranes", Biological Interfaces - Interfacing with Biology, University of Leeds (International Conference)
Year(s) Of Engagement Activity 2016
 
Description Simon Connell Conference talk - Fast Scan AFM of lipid dynamics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact 13-15th December 2016, "Fast Scan AFM of lipid dynamics" UK SPM Conference, Department of Materials Science and Metallurgy, Cambridge University.
Year(s) Of Engagement Activity 2016
 
Description Simon Connell Conference talk - Fluctuating Lipid Nanodomains near Critical Transitions 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact 4th-8th July 2016 "Fluctuating Lipid Nanodomains near Critical Transitions", Complexity in the Chemistry and Physics of lipid membranes, Telluride TSRC Workshop, Telluride , Colorado, USA.
Year(s) Of Engagement Activity 2016
 
Description Simon Connell Conference talk - Quantifying lipid membrane dynamics using Fast Scan AFM 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact 26th-30th August 2016 "Quantifying lipid membrane dynamics using Fast Scan AFM", SPM-on-SPM, Changchun, China
Year(s) Of Engagement Activity 2016
 
Description Simon Connell seminar talk - AFM Studies of Bilayer Dynamics, Structure and Growth in the Three-Phase Region 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact 13th February 2015, "AFM Studies of Bilayer Dynamics, Structure and Growth in the Three-Phase Region", Departmental Seminar, Olmsted Group, Georgetown University, USA.
Year(s) Of Engagement Activity 2015
 
Description Simon Connell seminar talk - Critical Fluctuations in Lipid Bilayers 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact 27th October 2016 "Critical Fluctuations in Lipid Bilayers", Theoretical Physics Group Seminar, Department of Physics, University of Warwick
Year(s) Of Engagement Activity 2016
 
Description Simon Connell seminar talk - Lipid Nanodomain Dynamics: Fast AFM. Line tensions, Ising Models and coupling Modes 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact 8th Feb 2017, "Lipid Nanodomain Dynamics: Fast AFM. Line tensions, Ising Models and coupling Modes", London School of Nanotechnology (LCN) Colloquium.
Year(s) Of Engagement Activity 2017
 
Description Simon Connell seminar talk - Membranes, Microfluidics and Microbubbles: from fundamentals to clinical application 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact 13th April 2015 "Membranes, Microfluidics and Microbubbles: from fundamentals to clinical application", Interdisciplinary Computing and Complex BioSystems Research Group, School of Computing Science, University of Newcastle
Year(s) Of Engagement Activity 2015
 
Description Simon Connell seminar talk - Structure, Dynamics and Mechanics of Three-Phase Lipid Bilayers 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact 16th February 2015, "Structure, Dynamics and Mechanics of Three-Phase Lipid Bilayers", Departmental Seminar, Dufresne Group, Yale University, USA.
Year(s) Of Engagement Activity 2015
 
Description Simon Connell seminar talk - Structure, Dynamics and Mechanics of Three-Phase Lipid Bilayers 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact 13th March 2015, "Structure, Dynamics and Mechanics of Three-Phase Lipid Bilayers", Departmental Seminar, Ando Group, Kanazawa University, Japan,
Year(s) Of Engagement Activity 2015
 
Description SoftComp Annual meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Presentation in Ancona, Italy at the SoftComp annual meeting - Demixing transitions in Bicontinuous Cubic Phases close to the critical point
Year(s) Of Engagement Activity 2016
 
Description StatPhys 26 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Talk at StatPhys, Lyon, France - Demixing transitions in Bicontinuous Cubic Phases close to the critical point
Year(s) Of Engagement Activity 2016
 
Description Vesicle Carriers Symposium, Manchester, March 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Presented talk at the University of Manchester on Vesicle Carriers. The symposium was spread over 2 days - 4th and 5th March 2016 and was fully attended.
Year(s) Of Engagement Activity 2016
 
Description Zing Computational Chemical Biology Conference, 6-10 August 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Zing Computational Chemical Biology conference, invited delegates from a worldwide audience, held over the 6-10 August 2015.
Year(s) Of Engagement Activity 2015