Sonopill: minimally invasive gastrointestinal diagnosis and therapy

Lead Research Organisation: University of Dundee
Department Name: Imaging and Technology

Abstract

Capsule endoscopy for medical diagnosis in the gastrointestinal (GI) tract has emerged only in the past 10 years. Now established in "pillcams", which have benefitted more than 1 m patients worldwide, it is a clear candidate for further innovation.

Most capsule endoscopy devices record and transmit video data representing the visual appearance of the inside of the gut, but work has begun on other diagnostic techniques, such as the measurement of pH, and there has been some research into the use of capsules for treatment as well.

Medical ultrasound imaging is a safe, inexpensive technique which can be applied in real-time at the point of care. Ultrasound is also capable of treatment through focused ultrasound surgery and, in research, for targeted drug delivery.

The core of the Sonopill programme is the exploration of ultrasound imaging and therapeutic capabilities deployed in capsule format. This will be supported by extensive pre-clinical work to demonstrate the complementary nature of ultrasound and visual imaging, along with studies of multimodal diagnosis and therapy, and of mechanisms to control the motion of the Sonopill as it travels through the GI tract.

This brings research challenges and opportunities in areas including ultrasound device and systems design, microengineering and microelectronic packaging, autonomous capsule positioning, sensor suites for diagnosis and intervention, and routes to translation into clinical practice.

Our carefully structured but open-ended approach maximises the possibility to meet these research challenges while delivering for the UK a sustainable international lead in multimodality capsule endoscopy, to provide greater capabilities for the clinician, more acceptable practice for the patient population, and lower costs for economic wellbeing.

Planned Impact

The gastrointestinal (GI) tract is subject to many different diseases. Some of these are described collectively as inflammatory bowel disease (IBD), notably including Crohn's disease and ulcerative colitis. Others relate to the reaction of the bowel to food, such as Coeliac disease, or to difficult physiological issues such as small bowel motility. Finally, cancer is a major issue, with oesophageal, stomach and colorectal cancers collectively forming more than 20% of all cases of cancer worldwide, and even cancer of the small bowel, a less common form, affecting more than 1 in 500 people in North America. These diseases are the target for Sonopill and the GI tract is its domain.

Sonopill will impact GI tract disease in three ways. First, it will provide a new means of diagnosis, including for early tissue dysplasia. Endoscopic ultrasound has been highlighted as a major innovation in endoscopy. Through the application of high resolution ultrasound (HRUS), the Sonopill will represent just as large a step forward in diagnosis from the present optical pillcams, themselves a revolutionary development in difficult diagnoses. Second, it will provide a new means of treatment. Using high intensity focused ultrasound (HIFU) for localised focused ultrasound surgery (FUS) and ultrasound-mediated targeted drug delivery (TDD), and with the potential for other means of hyperthermia such as microwave ablation, it will offer the GI consultant new therapeutic possibilities. Third, it will provide a means to further research in the GI tract, allowing repeated observation in a way that is presently impossible because of the invasive nature of conventional endoscopy and colonoscopy, and difficulty in passing enteroscopes through the entirety of the GI tract.

To realise clinical impact, Sonopill must reach commercial reality. To that end, we have partnered with a dozen companies covering the complete spectrum of Sonopill research and production, from virtual prototyping (Weidlinger Associates) through MEMS fabrication (Semefab) to testing (Precision Acoustics) and access to clinical practice (Karl Storz Endoskope). These companies will join an Industrial Impact Group (IIG) to ensure we keep in mind commercial constraints. Highly experienced senior figures from industry and universities have also agreed to join our International Advisory Committee (IAC), such as Dr Dalmolin (SORIN), Prof. Rau (Aachen), Dr McLaughlin (Zonare Medical Systems) and Prof. ter Haar (Institute of Cancer Research), and these will be complemented by a Local Clinical Committee (LCC).

In reaching commercial reality, Sonopill will also have economic impact, as the technology emerging from the research is productionised, then realised in mass production. There will also be a significant economic impact in the NHS and other healthcare systems from the reduced costs of diagnosis and treatment. For example, whilst the present £500 cost of an existing pillcam is not dissimilar to the cost of a straightforward gastroscopy, even this relatively simple device leads to much quicker diagnosis of difficult cases, saving the cost of multiple gastroscopies and visits to the clinic. This will, in turn, have an impact on society, as diagnosis and treatment become easier and therefore intrude less into the everyday life of the patient. Sonopill will also impact people and skills, directly by providing challenging training and scientific and engineering research for its cohort of early stage researchers (ESRs), and indirectly through advocacy for science and engineering which will contribute to engagement of the general population with subjects within the science, technology, engineering and maths (STEM) subjects.

Organisations

Publications

10 25 50

Related Projects

Project Reference Relationship Related To Start End Award Value
EP/K034537/1 27/05/2013 13/09/2015 £5,003,714
EP/K034537/2 Transfer EP/K034537/1 14/09/2015 27/11/2018 £3,210,627
 
Description Capsule endoscopy for medical diagnosis in the gut, in which a pill with sensing capabilities is swallowed, has emerged only in the past 15 - 20 years. Now well established, it has benefited more than 4M patients worldwide and is a clear candidate for continuous innovation.

Most capsule endoscopy devices record video data representing the visual appearance of the inside of the gut, but work has begun on other diagnostic techniques, such as the measurement of pH, and there has been some research into the use of capsules for treatment as well.

Medical ultrasound imaging is a safe, inexpensive technique which can be applied in real-time at the point of care. Ultrasound is also capable of treatment through focused ultrasound surgery and, in research, for targeted drug delivery. The Sonopill programme combined medical ultrasound, both diagnostic and therapeutic, with capsule endoscopy and robotic manipulation for the first time.

The programme team identified relevant clinical targets, progressed development of early versions of capsule endoscopes, designed and tested special silicon chips to fit into the tiny volume of the pill and explored other possible functions for the pill, to complement ultrasound.
Exploitation Route Collaboration took place with Dr Weibao Qiu and other researchers at Shenzhen Institute of Advanced Technology, China, on development of a simplifed Pathfinder Pill and also in possible industrial applications of the Sonopill concept, to complement the healthcare applications that were and remain of immediate interest.

Discussion also took place with Dr Maya Thanou, Institute of Pharmacological Sciences, Kings College London, on drug delivery with the Sonopill, and collaborative work in this area gained studentship funding; a student is now in post and carrying out research actively, in partnership with the SME Curileum.
Sectors Aerospace, Defence and Marine,Electronics,Energy,Healthcare,Pharmaceuticals and Medical Biotechnology

URL http://www.gla.ac.uk/sonopill/
 
Description The Sonopill programme research team was in place for 5 1/2 years, according to staff recruitment dates. Many findings were realised, with significant engagement with the scientific and clinical communities and the general public. The Programme had 15 industrial partners with assigned points of contact with the programme team. Many of the companies provided advice and support in kind and the Sonopill team presented challenges to them and supported their horizon scanning and future product research. A strategic link was established between the Sonopill team and Dundee Science Centre (DSC), through a Wellcome Trust funded grant with the Institute for Medical Science and Technology, the host for the programme. This resulted in a permanent exhibition and educational provision. Further related links were also made with Glasgow Science Centre, the largest such centre in the UK.
First Year Of Impact 2015
Sector Education,Electronics,Healthcare
Impact Types Cultural,Societal,Economic

 
Description EPSRC Doctoral Training Grant - Julia Faerber
Amount £54,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 03/2014 
End 03/2018
 
Description EPSRC Doctoral Training Grant - Vasileios Mitrakos
Amount £54,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 12/2014 
End 12/2018
 
Description EPSRC Doctoral Training Partnership - Sadeque Khan
Amount £54,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 02/2017 
End 02/2021
 
Description EPSRC Impact Acceleration Account
Amount £10,000 (GBP)
Organisation Heriot-Watt University 
Sector Academic/University
Country United Kingdom
Start 12/2016 
End 03/2017
 
Description EPSRC Impact Acceleration Account
Amount £10,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 08/2016 
End 03/2017
 
Description F.Stewart - EPSRC Doctoral Training Grant
Amount £53,178 (GBP)
Organisation University of Dundee 
Sector Academic/University
Country United Kingdom
Start 07/2014 
End 06/2017
 
Description Glasgow Research Partnership in Engineering (GRPE) Postdoctoral and Early Career Researcher Exchanges
Amount £3,250 (GBP)
Organisation University of Glasgow 
Department School of Engineering Glasgow
Sector Academic/University
Country United Kingdom
Start 02/2017 
End 07/2017
 
Description NC3R
Amount £269,539 (GBP)
Funding ID NC/M001156/1 
Organisation National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2014 
End 11/2017
 
Description R.Yanakieva - EPSRC Doctoral Training Grant
Amount £53,178 (GBP)
Organisation University of Dundee 
Sector Academic/University
Country United Kingdom
Start 02/2014 
End 01/2017
 
Description Sonopill - Shenzhen Research Grant
Amount ¥200,000 (CNY)
Organisation Shenzhen City Council 
Sector Public
Country China
Start 09/2014 
End 08/2016
 
Title Development of Small Bowel Tissue Phantom for Microultrasound (µUS) Investigation 
Description To investigate µUS for transmural imaging, a phantom which is biologically similar to the human GI tract which allows for experiments in which the physiological environment and acoustic properties of the tissue can be manipulated to mimic disease. A phantom utilizing porcine small bowel tissue, which largely mimics human GI histology, has been developed for experimentation with µUS. The phantom was scanned using a single element µUS scanner mounted on a stage motor able to travel in both the x and y-axes to provide biaxial scans for analysis. To simulate physiological conditions, the tissue samples were perfused with degassed phosphate buffer saline (dPBS) at 200 ml/hour via a syringe perfusor to establish sufficient mucosal characterization. Per-fusion was established via a cannula inserted in the mesenteric vessel of the tissue. 
Type Of Material Database/Collection of data 
Year Produced 2014 
Provided To Others? Yes  
Impact Work has been used to investigate quantitative ultrasound techniques of inflammatory imaging. Ref: 10.1109/ULTSYM.2015.0304 (2015) Microultraound and small bowel inflammation: Tissue phantom studies. 
 
Description Academic and Industry partnership with AFM Ltd relating to the SONOPILL programme 
Organisation AFM
Country United Kingdom 
Sector Private 
PI Contribution Academic input to future project research
Collaborator Contribution Technical input, advice and assistance
Impact Enhanced academic/industry communication
Start Year 2013
 
Description Academic and Industry partnership with ZONARE relating to the SONOPILL programme 
Organisation ZONARE Medical Systems, Inc.
Country United States 
Sector Private 
PI Contribution Academic perspective to future project research
Collaborator Contribution Advice on SONOPILL programme from an Industry perspective
Impact Enhanced Academic/industry communication on project research
Start Year 2013
 
Description Academic/Industry partnership with Crystapol International Ltd relating to SONOPILL programme 
Organisation Crystapol International
Country United Kingdom 
Sector Private 
PI Contribution Academic partnership on future project research
Collaborator Contribution Advice on SONOPILL programme from an Industry perspective
Impact Enhanced Academic/industry communciation
Start Year 2013
 
Description Academic/Industry partnership with Diagnostic Sonar Ltd relating to SONOPILL programme 
Organisation Diagnostic Sonar
Country United Kingdom 
Sector Private 
PI Contribution Academic perspective to future project research
Collaborator Contribution Advice on SONOPILL programme from an Industry perspective
Impact Enhanced Academic/industry communication on project research
Start Year 2013
 
Description Academic/Industry partnership with Disco Corporation relating to SONOPILL programme 
Organisation DISCO Corporation
Department DISCO Hi-Tec UK
Country United Kingdom 
Sector Private 
PI Contribution Academic perspective to future project research
Collaborator Contribution Access to development laboratory and advice on SONOPILL programme from an Industry perspective
Impact Enhanced Academic/industry communication on project research
Start Year 2013
 
Description Academic/Industry partnership with Envision Design Ltd relating to SONOPILL programme 
Organisation Envision Design
Country United Kingdom 
Sector Private 
PI Contribution Academic perspective to future project research
Collaborator Contribution Advice on SONOPILL programme from an Industry perspective
Impact Enhanced Academic/industry communication on project research in the medical acoustics field
Start Year 2014
 
Description Academic/Industry partnership with Israeli Institute of Technology (Technion) relating to SONOPILL programme 
Organisation Technion - Israel Institute of Technology
Country Israel 
Sector Academic/University 
PI Contribution International academic perspective to future project research
Collaborator Contribution Advice on SONOPILL programme from an International academic perspective
Impact Enhanced Academic to academic communication on project research
Start Year 2013
 
Description Academic/Industry partnership with Karl Storz Endoscopy (UK) Ltd relating to SONOPILL programme 
Organisation Karl Storz GmbH & Co. KG
Country Germany 
Sector Private 
PI Contribution Academic perspective to future project research
Collaborator Contribution Technical support and advice on SONOPILL programme from an Industry perspective
Impact Enhanced Academic/industry communication on project research
Start Year 2013
 
Description Academic/Industry partnership with Meggitt Sensing Systems relating to SONOPILL programme 
Organisation Meggitt A/S
Country Denmark 
Sector Academic/University 
PI Contribution Academic perspective to future project research
Collaborator Contribution Advice on SONOPILL programme from an Industry perspective and limited supply of samples for prototyping and testing
Impact Enhanced Academic/industry communication on project research
Start Year 2013
 
Description Academic/Industry partnership with Merlin Circuit Technology Ltd relating to SONOPILL programme 
Organisation Merlin Circuit Tech Ltd
Country United Kingdom 
Sector Private 
PI Contribution Academic perspective to future project research
Collaborator Contribution Supply of raw flexible circuits, access to interconnect systems in house and advice on SONOPILL programme from an Industry perspective
Impact Enhanced Academic/industry communication on project research
Start Year 2013
 
Description Academic/Industry partnership with National Instruments Corporation (UK) Ltd relating to SONOPILL programme 
Organisation National Instruments Corp (UK) Ltd
Country United Kingdom 
Sector Private 
PI Contribution Academic perspective to future project research
Collaborator Contribution Training and ongoing support to the academic team and advice on SONOPILL programme from an Industry perspective
Impact Enhanced Academic/industry communication on project research
Start Year 2013
 
Description Academic/Industry partnership with National Physical Laboratory (NPL) relating to SONOPILL programme 
Organisation National Physical Laboratory
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic perspective to future project research
Collaborator Contribution Access to key NPL facilities in materials and ultrasound characterisation, and advice on SONOPILL programme from an Industry perspective
Impact Enhanced Academic/industry communication on project research
Start Year 2013
 
Description Academic/Industry partnership with Precision Acoustics Ltd relating to SONOPILL programme 
Organisation Precision Acoustics Ltd
Country United Kingdom 
Sector Private 
PI Contribution Academic perspective to future project research
Collaborator Contribution Discounts on products, access to measurement facilities and advice on SONOPILL programme from an Industry perspective
Impact Enhanced Academic/industry communication on project research
Start Year 2013
 
Description Academic/Industry partnership with Scottish Health Innovations Ltd (SHIL) relating to SONOPILL programme 
Organisation Scottish Health Innovations Ltd (SHIL)
Country United Kingdom 
Sector Private 
PI Contribution Academic perspective to future project research
Collaborator Contribution Advice and evaluation of the SONOPILL programme as it relates to commercialisation processes in the healthcare sector
Impact Enhanced Academic/ NHS communication on project research
Start Year 2013
 
Description Academic/Industry partnership with Selex ES relating to SONOPILL programme 
Organisation Selex ES
Country Italy 
Sector Private 
PI Contribution Academic perspective to future project research
Collaborator Contribution Advice on SONOPILL programme from an Industry perspective
Impact Enhanced Academic/industry communication on project research
Start Year 2013
 
Description Academic/Industry partnership with Semefab relating to SONOPILL programme 
Organisation Semefab (Scotland) Ltd
Country United Kingdom 
Sector Private 
PI Contribution Academic perspective to future project research
Collaborator Contribution Advice on SONOPILL programme from an Industry perspective
Impact Enhanced Academic/industry communication on project research
Start Year 2013
 
Description Academic/Industry partnership with Sorin Group relating to SONOPILL programme 
Organisation Sorin Group
Country Italy 
Sector Private 
PI Contribution Academic perspective to future project research
Collaborator Contribution Advice on SONOPILL programme from an Industry perspective
Impact Enhanced Academic/industry communication on project research
Start Year 2013
 
Description Academic/Industry partnership with Weidlinger Associates Ltd relating to SONOPILL programme 
Organisation Weidlinger Associates
Country United States 
Sector Private 
PI Contribution Academic perspective to future project research
Collaborator Contribution Specifically allocated support of Weidlinger staff and advice on SONOPILL programme from an Industry perspective plus software licences for PZFlex.
Impact Enhanced Academic/industry communication on project research
Start Year 2013
 
Description Collaboraton with School of Textiles, Heriot Watt in sensor integration 
Organisation Heriot-Watt University
Department School of Textiles and Design
Country United Kingdom 
Sector Academic/University 
PI Contribution Wireless pressure technology under development lends itself to wearable applications because of its high sensitivity in the tactile regime, ease of integration and passive operation without the need of interconnections
Collaborator Contribution Wok carried out in area of sensors to be integrated and tested in medical compression hosiery for continuous monitoring of the pressure gradients the garment exerts on specific sites
Impact Nothing specific to date - udner development
Start Year 2015
 
Description European Union sponsored Cost action for wireless power transfer 
Organisation European Cooperation in Science and Technology (COST)
Country Belgium 
Sector Public 
PI Contribution Applied and accepted as a member of the action group
Collaborator Contribution To address efficient Wireless Power Transmission (WPT) circuits, systems and strategies specially tailored for battery-less systems and establish Europe as a leading scientific and industrial player in this field,
Impact Initially participating as a member of the action group
Start Year 2014
 
Description Fraunhofer IAPR - Research partnership for the packaging and supply of bare die ICs 
Organisation Fraunhofer Society
Department Fraunhofer Institute for Applied Polymer Research
Country Germany 
Sector Private 
PI Contribution Research partnership established to look at IC packaging and supply
Collaborator Contribution As above working on a research partnership for the packaging and supply of bare die ICs
Impact No reportable outcomes as yet
Start Year 2014
 
Description Harvard University - Research partnership for joint research 
Organisation Brigham and Women's Hospital
Country United States 
Sector Hospitals 
PI Contribution Joint research on the wireless power transfer topic
Collaborator Contribution Dr Sai Chun of Harvard Medical School collaborates on this joint research
Impact Joint research recently established no reportable outputs or outcomes as yet.
Start Year 2014
 
Description Heriot-Watt University - Microwave Research Group 
Organisation Heriot-Watt University
Country United Kingdom 
Sector Academic/University 
PI Contribution Working on the development of wireless data and power transfer
Collaborator Contribution Dr George Goussetis working alongside Sumanth Kumar Pavuluri in this research partnership
Impact Research partnership established but no reportable outputs
Start Year 2014
 
Description Roslin Institute, The Royal (Dick) School of Veterinary Studies, University of Edinburgh 
Organisation University of Edinburgh
Department Royal School of Veterinary Studies
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of devices to be tested in vivo by the Sonopill team, Roslin Institute provided of large animal facility for in vivo studies.
Collaborator Contribution Prof E Clutton of the Royal School of Veterinary Studies has presented at the Sonopill Monthly Meeting regarding animal testing and associated ethics (20160713). Discussion regards the development of a large animal disease model in discussion.
Impact Ongoing collaboration
Start Year 2016
 
Description Shenzhen Institute of Advanced Technology, China. 
Organisation Shenzhen University
Department Institute of Advanced technology
Country China 
Sector Academic/University 
PI Contribution Secondment of V Seetohul to Shenzhen Institute of Advanced Technology, China between 20161119-20161223.
Collaborator Contribution Talks at the IEEE-EMBS Shenzhen Chapter, 610th Academic Seminar on biomedical and health Engineering, Shenzhen, China. (20161206) and Hong Kong Polytechnic University, Departmental Seminar, Hong Kong.(20161219). Organisation of Shenzhen Rotatory Ultrasound Capsule to be tested in vivo at the Roslin Institute, University of Edniburgh. Perspective collaboration talks with Sonolepu, Shenzhen, China (20161202), CNIR Hurricane technology, Shenzhen, China (20161207) and SX Ultrasonics, Shenzhen, China (20161212).
Impact In vivo tests
Start Year 2016
 
Description Ultracap 
Organisation Scottish Health Innovations Ltd (SHIL)
Country United Kingdom 
Sector Private 
PI Contribution Potential improvement of the surveillance of Barrett's Oesophagus utilising high frequency microultrasound
Collaborator Contribution Financial
Impact Research currently ongoing involving gastroenterology, bench and translational work
Start Year 2015
 
Description Ultrasound in a needle for guidance in regional anaesthesia 
Organisation Royal Infirmary of Edinburgh
Country United Kingdom 
Sector Hospitals 
PI Contribution Collaboration on research into bonding technology
Collaborator Contribution Collaboration on research in placement of anaesthesia
Impact None applicable as yet, still active
Start Year 2015
 
Title Pathfinder pill 
Description Pathfinder Pill prototype 
IP Reference GB1405392.0 
Protection Patent application published
Year Protection Granted 2014
Licensed No
Impact The Pathfinder Pill has been divided into a set of working zones within which experiments have to be carried out to optimise the components. An acoustic mirror test rig has been designed and is being produced with 3D printing, this will asses the mirror characteristics and motor rotation issues.
 
Description I'm an engineer get me out of here 2016 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact A free online event where school students meet and interact with engineers in an effort to both educate the students and also entice them into a career in STEM. The students pose questions to the researchers regarding their particular research or general area of research. The researchers who give the best answer are voted into the next round with a winner ultimately declared. This event has been running for several years across the UK and has found to be an excellent means of discussing science with a large number of students across the UK. Ms. J. Faerber entered the event.
Year(s) Of Engagement Activity 2016
URL http://imanengineer.org.uk/
 
Description 37th Ann. Int. Conf. IEEE Eng. Med. Biol. Soc 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact SonoCAIT Sonication Capsule for Autonomous Imaging and Therapy, a Proof of Concept Device
Presented by A. Verbeni
Year(s) Of Engagement Activity 2015
 
Description 3rd European Symposium on Focused Ultrasound Therapy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Capsule-based Ultrasound-mediated Targeted Gastrointestinal Drug Delivery.
Presented by F. Stewart
Year(s) Of Engagement Activity 2015
 
Description 4th Oncological Eng. Conf., Leeds 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The Sonopill Programme
Presented by B.F. Cox
Year(s) Of Engagement Activity 2015
 
Description 4th Oncological Engineering Conference: SonoCAIT Sonication Capsule for Autonomous Imaging and Therapy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact SonoCAIT: Sonication Capsule for Autonomous Imaging and Therapy.
Presented by F. Stewart
Year(s) Of Engagement Activity 2015
 
Description Attendance at European Microwave Week, Rome, Italy October 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation provided opportunities to network and stimulated further discussions

Further interest in the work on SONOPILL was generated
Year(s) Of Engagement Activity 2014
URL http://www.eumweek.com/
 
Description Attendance at Royal Academy of Engineering Ingenious Scheme 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk on "Small plumbing! Empowering the next generation of microfluidic engineers!" resulted in further discussion with peers

Went on to engage in further Public Engagement activities and acted as a STEM ambassador
Year(s) Of Engagement Activity 2014
URL http://www.raeng.org.uk/
 
Description Clinical orientated tutorials 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Participants in your research and patient groups
Results and Impact Engineering staff were provided with an overview of the GUI system, simulated endoscopy, examining disorders of interest and an overview of clinical trials

Engineering staff gained a wider knowledge of the impact of their research across the SONOPILL programme and it's relation to clinical trials. Future tutorials to be organised for a wider audience
Year(s) Of Engagement Activity 2015
 
Description Conference Presentation - SonoCAIT: Sonication Capsule for Autonomous Imaging and Therapy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact Talk sparked questions and further discussion

N/A
Year(s) Of Engagement Activity 2015
 
Description Conformal Meander Shaped Antenna for Biotelemetry in endoscopic Capsules 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk sparked discussion

Julia Faerber was invited to give other presentations/talks and included in conference proceeding of the 2015 Loughborough Antennas and Propagation Conference
Year(s) Of Engagement Activity 2015
 
Description Dundee Science Centre - STEM Ambassador Training 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Participants in your research and patient groups
Results and Impact Induction/Training/workshop to strengthen the collaboration between Dundee Science Centre and SONOPILL staff.



Following the induction programme Public Engagement events were scheduled to allow SONOPILL team to engage with schools, the public, other institutions on their research
Year(s) Of Engagement Activity 2014
URL http://www.dundeesciencecentre.org.uk
 
Description Dundee Science Centre Meet the Researcher event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Schools visited the Science centre and met scientist from different areas who showed them examples of applied technology based on their discoveries.
Year(s) Of Engagement Activity 2019
 
Description Dundee Science Centre Sonopill Demonstration 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact 28.02.17 - Hands on demonstration of Sonopill at Dundee Science Centre event for visiting secondary school children from the wider area (Angus and Perthshire).
Year(s) Of Engagement Activity 2008,2017
 
Description Dundee Science Festival Family Fun Day 2015 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Resulted in informal discussions and questions.

School pupil requested tour or lab facilities
Year(s) Of Engagement Activity 2015
 
Description ESPRC Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presented work with Sonopill team at EPSCR showcase event in London on 21.02.18. The EPSRC event is designed to promote the importance of EPSRC investments, in the context of UK prosperity. Our presentation was titled "Looking Inside Your Gut" which fell under the Healthy Nation category.
Year(s) Of Engagement Activity 2018
 
Description Edinburgh Explorathon 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Presented aims and progress of the SONOPILL programme to the public and in [articular children from economically disadvantaged areas

Further events have been scheduled following the positive response and informal discussions
Year(s) Of Engagement Activity 2015
 
Description Edinburgh International Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Talk sparked questions and discussions by groups of all ages and activity from primary school to communities both within and outwith the educational environment.

An invitation by the event organiser Matt Wright was received to submit material for the Abu Dhabi Science Festival 2015; and Edinburgh International Science Festival 2015
Year(s) Of Engagement Activity 2014
URL http://www.sciencefestival.co.uk
 
Description Explorathon 2015 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact As part of the Explorathon event, which is part of the European Researchers' Night, we talked to over 70 students. Many of whom were disadvantaged areas as part of the widening access program of HWU. Student numbers were assessed from the number of stickers given away. We kept the stickers so they can be used as a similar metric in future.
The students were engaged with the Sonopill project, asking a lot of questions regarding ultrasonic imaging, the future of medicine and microengineering. The event was hosted by Dr. H. Lay, Dr. B. Cox and Dr. G. Cummins
Year(s) Of Engagement Activity 2015
URL http://www.explorathon.co.uk/
 
Description Hosting Art students in lab 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact 3rd year Jewellery students visited the lab and learned about our science and how we do it.
Year(s) Of Engagement Activity 2018
 
Description IMPACT Research creativity@home event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact Exploration of spin-off project potential

Invitations to share subject matter expertise and future collaboration
Year(s) Of Engagement Activity 2015
 
Description Ingenious Women Project 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact 08.03.18 Guest speaker at Ingenious Women Event that took place in Dundee. The title of my talk was "Life and work on many coasts". This is a national networking event for the Enterprising & Ingenious Women Scotland programme. This networking event is open to all women of all career stages who are interested in reflecting on their careers and building their networks.
Year(s) Of Engagement Activity 2018
 
Description Int. Conf. on Intelligent Robots and Sys 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Robotic requirements for diagnosis and therapy with ultrasound capsule endoscopy
Presented by V. Seetohul
Year(s) Of Engagement Activity 2015
 
Description Invited Speaker - Capsule-based Ultrasound-mediated Targeted Drug Delivery 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact Talk sparked discussions and questions

Follow up meetings and possible collaboration
Year(s) Of Engagement Activity 2015
 
Description Invited Speaker - Robotic requirements for diagnosis and therapy with ultrasound capsule endoscopy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Participants in your research and patient groups
Results and Impact Following the presentation opportunities for discussion and networking were established.

Discussions on possible collaborative opportunities have since been scheduled with participants at the meeting
Year(s) Of Engagement Activity 2015
 
Description Invited Speaker - Ultrasound capsule endoscopy for diagnosis and therapy: A new frontier in autonomous robotic systems 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact TBC
Year(s) Of Engagement Activity 2014
 
Description Invited Talk - Nijmegan - Prospects of Image-guided therapy in the Gastrointestinal Tract 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact The talk was an invited talk at the autumn 2016 biannual meeting of the Dutch Society of Medical Ultrasound. The meeting pulls in researchers from all over the Netherlands and the talk featured discussion of the therapeutic applications of ultrasound, including discussion of the therapeutic aspects of the SONOPILL project. The talk was given by Dr. Lay.
Year(s) Of Engagement Activity 2016
URL http://www.nvmu.nl/Autumnmeeting%20NVMU%202016.pdf
 
Description Invited Talk - Rotterdam - Utilisation of high resolution ultrasound for sensing in the body 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact ~20 students and researchers from Erasmus Rotterdam attended a 1 hour talk by Prof. Cochran and Dr. Lay about the use of high resolution ultrasound for sensing in the body. This featured significant coverage of the work done in the USINN and SONOPILL projects.
Year(s) Of Engagement Activity 2016
 
Description Invited Talk - TU Delft - Utilisation of high resolution ultrasound for sensing in the body 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact ~30 students from Delft University of Technology attended a 1 hour talk by Prof. Cochran and Dr. Lay about the use of high resolution ultrasound for sensing in the body. This featured significant coverage of the work done in the USINN and SONOPILL projects.
Year(s) Of Engagement Activity 2016
 
Description Invited Talk - University of Strathclyde - Sonopill: From Design to Trial and Beyond 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact The invited talk was part of the University of Strathclyde, Department of Biomedical Engineering seminar series. The meeting was attended by members of the biomedical engineering community at the University of Strathclyde. The talk gave a general overview of the goals of the Sonopill project and what has been done to date. The talk was given by Dr. Cummins
Year(s) Of Engagement Activity 2017
 
Description Invited Talk, Fluorescence Capsule Endoscopy Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invitation to attend/speak at "Fluorescence Capsule Endoscopy Workshop (Project No. HTC-16-056)" Leeds, UK. 30th November 2017-1st December 2017. Talk on multi (-modal) capsules.
Year(s) Of Engagement Activity 2017
URL https://www.gla.ac.uk/research/az/sonopill/news/headline_568313_en.html
 
Description Invited Talk, Minimally Invasive Endoscopy Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Cox, BF "Multimodal Capsule Diagnosis: Modalities and Combinations" Invited Speaker: Minimally Invasive Endoscopy Workshop. The Royal Scots Club Edinburgh, March 21, 2017. Engineers and clinicians passionate about minimally invasive endoscopy are invited to an open one-day event which will promote dialogue and a better understanding of clinician's needs and engineer's capabilities.
Year(s) Of Engagement Activity 2015,2017
URL https://www.gla.ac.uk/research/az/sonopill/events/headline_503651_en.html
 
Description Invited speaker 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Updated the Endoscopy Unit, Edinburgh Royal Infirmary and generated discussion afterwards

After the talk dates were scheduled for further sharing of information/discussion at SONOPILL research technical review meetings
Year(s) Of Engagement Activity 2015
 
Description Lecture about career in Science to Life Sciences UG students at Univeristy Dundee 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Career talk to UG students to inform them about ways to make choices, how to manage, share experiences.
Year(s) Of Engagement Activity 2019
 
Description Lecture at Professor Alan Clark Memorial Event and European Stem Cell Research Institute 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation of results and ongoing work relating to all awards
Year(s) Of Engagement Activity 2016
 
Description Medical Marvels show - Dundee Science Centre 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Medical Marvels Show - Dundee Science Centre Talking to high school students and demonstrating my work
Year(s) Of Engagement Activity 2018
 
Description Meet the expert 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Demonstrations to school children at the Science Centre about colonoscopy, bowel biology, ultrasound, etc.
Year(s) Of Engagement Activity 2017
 
Description Microultrasound and small bowel inflammation tissue phantom studies 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk sparked discussion at the IEEE conference in Taiwan.

Increased interest in the project and SONOPILL in general
Year(s) Of Engagement Activity 2015
 
Description National Instruments Week 2014 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact To discuss project development, quality control and general progress monitoring in medical device research

Collaborative links established to develop areas of mutual research interest
Year(s) Of Engagement Activity 2014
 
Description Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Participation on UoD applicant day- aimed to attract UG offer holders to choose UoD as final choice
Year(s) Of Engagement Activity 2018
 
Description Open day for potential UG students 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Participation on UoD Open day - aimed to attract UG applications for 2019/2020
Year(s) Of Engagement Activity 2018
 
Description Presentation - Capsule-based Ultrasound-mediated Targeted Gastrointestinal Drug Delivery 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Participants in your research and patient groups
Results and Impact Talk sparked discussion and establishment of possible collaborative contacts

N/A
Year(s) Of Engagement Activity 2015
 
Description Presentation at Anglo-French Physical Acoustics Conference 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A talk was presented on quantitative analysis of microultrasound data from ex vivo porcine bowel specimens in the gastroesophageal junction region.
Year(s) Of Engagement Activity 2016
URL http://afpac2016.iopconfs.org/home
 
Description Presentation at Photonex Scotland Roadshow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation of work relating to numerous awards
Year(s) Of Engagement Activity 2016
 
Description Presentation at |Lumps and Bumps" meeting on cancer and placentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation to audience including medical and scientific practitioners presenting work relating to all awards
Year(s) Of Engagement Activity 2016
 
Description Presentation of Sonopill to the general public as part of the Dundee science festival 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Demonstration of endoscopy to the general public
Year(s) Of Engagement Activity 2015
 
Description RAEng Imagineer panel member (University of Glasgow) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Groups of ~50 school pupils a day (five day events + one public evening event) attended an hour and a half long presentation including a multimedia presentation on engineering ethics and it's responsibilities in the modern world. This was followed by a Q&A session with a panel of engineers from across the University covering topics from 'what is engineering' to the required schooling, to ethical debates.
Year(s) Of Engagement Activity 2017
URL https://www.gla.ac.uk/events/sciencefestival/community/imagineer/
 
Description RSM-UKMSA Conf 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Development of Small Bowel Tissue Phantom for Microultrasound (µUS) Investigation
Year(s) Of Engagement Activity 2015
 
Description Related SONOPILL articles/Internet Media interest 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Publicity at launch of SONOPILL programme which resulted in request for further information from members of the public and colleagues int he field.

Following the initial launch further local and regional publicity promoting the SONOPILL programme sparked national interest.
Year(s) Of Engagement Activity 2013
URL http://finance.yahoo.com/news/disruptions-medicine-monitors-150039052.html
 
Description Robotastic at Dynamic Earth, Edinburgh 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Sonopill was invited to take part in Robotastic at Dynamic Earth, this was a free event in one of Edinburgh's most popular tourist attractions. It was held at the same time as a "Living Machines, 2016" a biomimetics conference. We had a lot of interest in our exhibit from conference attendees, tourists and children. The conference attendees were interested in the more technical aspects about this project and the tourists and children were interested in the general technical topic of miniaturised medical devices as well as the application of the device as a clinical diagnostic tool. Several people attending asked for more information on the project, some of whom spoke of their own experiences of conventional endoscopy were directed to the project website to learn more of our work. Two conference attendees also asked for the website address to learn more about the technical aspects of the project.
Year(s) Of Engagement Activity 2016
URL http://www.dynamicearth.co.uk/latest/blog/posts/2016/june/summer-space-tacular
 
Description SET for Britain 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Presentation of poster regarding research on wireless communications and power transfer being conducted within Sonopill by Ms. J. Faerber. The audience was mainly comprised of Members of both Houses of Parliament. Few of them have science or technology degrees but were engaged with the subject matter of the project. This engagement exercise raised awareness of the Sonopill project with policymakers.
Year(s) Of Engagement Activity 2015
URL http://www.setforbritain.org.uk/2015event.asp
 
Description STEM for Women (University of Glasgow) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact A full day event was run at University of Glasgow, sponsored by Monster, focused on speaking to girls and women about engagement with STEM subjects and careers. ~200 high-school girls were invited to attend a day workshop focused on career skills including interview prep, resumes and mentoring. Dr. Holly Lay participated as a mentor and mock interview participant.
Year(s) Of Engagement Activity 2016
URL http://monsterconfidence.co.uk/glasgow/
 
Description School visit to Breadalbane Academy, Aberfeldy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Following my presentation discussion took place among the pupils with many expressing interest in finding out more about SONOPILL and the research programme

We were encouraged to apply for a public engagement project grant and are awaiting the outcome.
Year(s) Of Engagement Activity 2014
 
Description Scientific presentation about work relating to multiple awards at "Single Cell Biology" at the Genome Campus HInxton, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Scientific presentation about work sharing work related to multiple awards
Year(s) Of Engagement Activity 2016
 
Description UK Therapeutic Ultrasound Interest Group meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Capsule-based Ultrasound-mediated Targeted Drug Delivery
Presented by F. Stewart
Year(s) Of Engagement Activity 2015
 
Description Ultrason. Biomed. Microscanning 2014, 9th International Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Simple microultrasound capsule endoscopy
Presented by V. Seetohul
Year(s) Of Engagement Activity 2014
 
Description Ultrasound capsule endoscopy for diagnosis and therapy: a new frontier in autonomous robotic systems 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Questions and answer session following the presentation

Follow up discussion with visits proposed
Year(s) Of Engagement Activity 2014
 
Description Video prepared by Wellcome Trust related to facility in which Sonopill was tested 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The Wellcome Trust wished to publicise the success of the facility it supports at Dryden Farm, Roslin, Edinburgh. It funded the preparation of a short video describing the facility and how it had been used by the Sonopill programme.
Year(s) Of Engagement Activity 2019
URL https://wellc.me/2tBxom3
 
Description Visit to Harvard 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Discussions abut potential collaboration and medical device development

Strong links established with Sai Chun Tang, Nobuhiko Hata and Nathan McDannold at Harvard
Year(s) Of Engagement Activity 2015