Sonopill: minimally invasive gastrointestinal diagnosis and therapy

Lead Research Organisation: University of Glasgow
Department Name: School of Engineering

Abstract

Capsule endoscopy for medical diagnosis in the gastrointestinal (GI) tract has emerged only in the past 10 years. Now established in "pillcams", which have benefitted more than 1 m patients worldwide, it is a clear candidate for further innovation.

Most capsule endoscopy devices record and transmit video data representing the visual appearance of the inside of the gut, but work has begun on other diagnostic techniques, such as the measurement of pH, and there has been some research into the use of capsules for treatment as well.

Medical ultrasound imaging is a safe, inexpensive technique which can be applied in real-time at the point of care. Ultrasound is also capable of treatment through focused ultrasound surgery and, in research, for targeted drug delivery.

The core of the Sonopill programme is the exploration of ultrasound imaging and therapeutic capabilities deployed in capsule format. This will be supported by extensive pre-clinical work to demonstrate the complementary nature of ultrasound and visual imaging, along with studies of multimodal diagnosis and therapy, and of mechanisms to control the motion of the Sonopill as it travels through the GI tract.

This brings research challenges and opportunities in areas including ultrasound device and systems design, microengineering and microelectronic packaging, autonomous capsule positioning, sensor suites for diagnosis and intervention, and routes to translation into clinical practice.

Our carefully structured but open-ended approach maximises the possibility to meet these research challenges while delivering for the UK a sustainable international lead in multimodality capsule endoscopy, to provide greater capabilities for the clinician, more acceptable practice for the patient population, and lower costs for economic wellbeing.

Planned Impact

The gastrointestinal (GI) tract is subject to many different diseases. Some of these are described collectively as inflammatory bowel disease (IBD), notably including Crohn's disease and ulcerative colitis. Others relate to the reaction of the bowel to food, such as Coeliac disease, or to difficult physiological issues such as small bowel motility. Finally, cancer is a major issue, with oesophageal, stomach and colorectal cancers collectively forming more than 20% of all cases of cancer worldwide, and even cancer of the small bowel, a less common form, affecting more than 1 in 500 people in North America. These diseases are the target for Sonopill and the GI tract is its domain.

Sonopill will impact GI tract disease in three ways. First, it will provide a new means of diagnosis, including for early tissue dysplasia. Endoscopic ultrasound has been highlighted as a major innovation in endoscopy. Through the application of high resolution ultrasound (HRUS), the Sonopill will represent just as large a step forward in diagnosis from the present optical pillcams, themselves a revolutionary development in difficult diagnoses. Second, it will provide a new means of treatment. Using high intensity focused ultrasound (HIFU) for localised focused ultrasound surgery (FUS) and ultrasound-mediated targeted drug delivery (TDD), and with the potential for other means of hyperthermia such as microwave ablation, it will offer the GI consultant new therapeutic possibilities. Third, it will provide a means to further research in the GI tract, allowing repeated observation in a way that is presently impossible because of the invasive nature of conventional endoscopy and colonoscopy, and difficulty in passing enteroscopes through the entirety of the GI tract.

To realise clinical impact, Sonopill must reach commercial reality. To that end, we have partnered with a dozen companies covering the complete spectrum of Sonopill research and production, from virtual prototyping (Weidlinger Associates) through MEMS fabrication (Semefab) to testing (Precision Acoustics) and access to clinical practice (Karl Storz Endoskope). These companies will join an Industrial Impact Group (IIG) to ensure we keep in mind commercial constraints. Highly experienced senior figures from industry and universities have also agreed to join our International Advisory Committee (IAC), such as Dr Dalmolin (SORIN), Prof. Rau (Aachen), Dr McLaughlin (Zonare Medical Systems) and Prof. ter Haar (Institute of Cancer Research), and these will be complemented by a Local Clinical Committee (LCC).

In reaching commercial reality, Sonopill will also have economic impact, as the technology emerging from the research is productionised, then realised in mass production. There will also be a significant economic impact in the NHS and other healthcare systems from the reduced costs of diagnosis and treatment. For example, whilst the present £500 cost of an existing pillcam is not dissimilar to the cost of a straightforward gastroscopy, even this relatively simple device leads to much quicker diagnosis of difficult cases, saving the cost of multiple gastroscopies and visits to the clinic. This will, in turn, have an impact on society, as diagnosis and treatment become easier and therefore intrude less into the everyday life of the patient. Sonopill will also impact people and skills, directly by providing challenging training and scientific and engineering research for its cohort of early stage researchers (ESRs), and indirectly through advocacy for science and engineering which will contribute to engagement of the general population with subjects within the science, technology, engineering and maths (STEM) subjects.

Related Projects

Project Reference Relationship Related To Start End Award Value
EP/K034537/1 27/05/2013 13/09/2015 £5,003,714
EP/K034537/2 Transfer EP/K034537/1 14/09/2015 27/11/2018 £3,210,627
 
Title Sonozilla: exhibit Dundee Design Festival (UNESCO) 20160525-20160528 
Description Ms. Annie Campbell produced a poster depicting the endoscopic design history in consultation with Dr. Ben Cox, the Clinical Research Fellow on the Sonopill programme. 
Type Of Art Image 
Year Produced 2016 
Impact Artwork provides historical timeline of endoscopy development and can be used with other public engagement events 
URL http://sonopill.dundee.ac.uk/blog/fraser-stewart/sonozilla-dundee-international-design-festival-vipi...
 
Title Sonozilla: exhibit Dundee Design Festival (UNESCO) 20160525-20160528 
Description Sonozilla, a (x10) mock-up of the Sonopill, this includes various diagnostic modalities and their respective electronics. 
Type Of Art Artefact (including digital) 
Year Produced 2016 
Impact Sonozilla highlighted the dimensions of individual components and their position within the capsule 
URL https://www.lewishallmark.com/sonopill-model
 
Description Please note that this award was set up through transfer of a previous award. As such, key findings are noted in the previous award.
Exploitation Route Please note that this award was set up through transfer of a previous award. As such, information on how to take forward findings is noted for the previous award.
Sectors Electronics,Healthcare

URL http://www.gla.ac.uk/sonopill/
 
Description Please note that this award was set up through transfer of a previous award. As such, narrative relating to impact has been noted for the previous award.
First Year Of Impact 2017
Sector Education,Electronics,Healthcare
Impact Types Cultural,Societal,Economic

 
Description iCASE award
Amount £95,042 (GBP)
Funding ID BB/M017079/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2016 
End 08/2020
 
Title Detecting cells with licensed replication origins in tissue 
Description We developed a method that reveals cells in freshly isolated tissues that have their replication origins licensed. Using an optimised extraction procedure we can now identify cells that have their Mcm proteins bound to DNA. This method can be applied to tissue from various organs directly isolated. 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact Combining our new method with EdU labelling reveals the cell cycle dynamics in whole tissue. This allows comparing wild type and diseased tissue (i.e. Inflammation, cancer) and has already revealed new information about stem cells in the intestinal crypt and their behaviour. We have now adapted this method to study the behaviour of oesophageal tissue. This will lead to new insights into the changes that precede currently detectable stages of oesophageal cancer. 
 
Description Academic and Industry partnership with AFM Ltd relating to the SONOPILL programme 
Organisation AFM
Country United Kingdom 
Sector Private 
PI Contribution Academic input to future project research
Collaborator Contribution Technical input, advice and assistance
Impact Enhanced academic/industry communication
Start Year 2013
 
Description Academic/Industry partnership with Diagnostic Sonar Ltd relating to SONOPILL programme 
Organisation Diagnostic Sonar
Country United Kingdom 
Sector Private 
PI Contribution Academic perspective to future project research
Collaborator Contribution Advice on SONOPILL programme from an Industry perspective
Impact Enhanced Academic/industry communication on project research
Start Year 2013
 
Description Academic/Industry partnership with Disco Corporation relating to SONOPILL programme 
Organisation DISCO Corporation
Department DISCO Hi-Tec UK
Country United Kingdom 
Sector Private 
PI Contribution Academic perspective to future project research
Collaborator Contribution Access to development laboratory and advice on SONOPILL programme from an Industry perspective
Impact Enhanced Academic/industry communication on project research
Start Year 2013
 
Description Academic/Industry partnership with Meggitt Sensing Systems relating to SONOPILL programme 
Organisation Meggitt A/S
Country Denmark 
Sector Academic/University 
PI Contribution Academic perspective to future project research
Collaborator Contribution Advice on SONOPILL programme from an Industry perspective and limited supply of samples for prototyping and testing
Impact Enhanced Academic/industry communication on project research
Start Year 2013
 
Description Academic/Industry partnership with National Instruments Corporation (UK) Ltd relating to SONOPILL programme 
Organisation National Instruments Corp (UK) Ltd
Country United Kingdom 
Sector Private 
PI Contribution Academic perspective to future project research
Collaborator Contribution Training and ongoing support to the academic team and advice on SONOPILL programme from an Industry perspective
Impact Enhanced Academic/industry communication on project research
Start Year 2013
 
Description Academic/Industry partnership with National Physical Laboratory (NPL) relating to SONOPILL programme 
Organisation National Physical Laboratory
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic perspective to future project research
Collaborator Contribution Access to key NPL facilities in materials and ultrasound characterisation, and advice on SONOPILL programme from an Industry perspective
Impact Enhanced Academic/industry communication on project research
Start Year 2013
 
Description Academic/Industry partnership with Selex ES relating to SONOPILL programme 
Organisation Selex ES
Country Italy 
Sector Private 
PI Contribution Academic perspective to future project research
Collaborator Contribution Advice on SONOPILL programme from an Industry perspective
Impact Enhanced Academic/industry communication on project research
Start Year 2013
 
Description Academic/Industry partnership with Weidlinger Associates Ltd relating to SONOPILL programme 
Organisation Weidlinger Associates
Country United States 
Sector Private 
PI Contribution Academic perspective to future project research
Collaborator Contribution Specifically allocated support of Weidlinger staff and advice on SONOPILL programme from an Industry perspective plus software licences for PZFlex.
Impact Enhanced Academic/industry communication on project research
Start Year 2013
 
Description Collaboraton with School of Textiles, Heriot Watt in sensor integration 
Organisation Heriot-Watt University
Department School of Textiles and Design
Country United Kingdom 
Sector Academic/University 
PI Contribution Wireless pressure technology under development lends itself to wearable applications because of its high sensitivity in the tactile regime, ease of integration and passive operation without the need of interconnections
Collaborator Contribution Wok carried out in area of sensors to be integrated and tested in medical compression hosiery for continuous monitoring of the pressure gradients the garment exerts on specific sites
Impact Nothing specific to date - udner development
Start Year 2015
 
Description European Union sponsored Cost action for wireless power transfer 
Organisation European Cooperation in Science and Technology (COST)
Country Belgium 
Sector Public 
PI Contribution Applied and accepted as a member of the action group
Collaborator Contribution To address efficient Wireless Power Transmission (WPT) circuits, systems and strategies specially tailored for battery-less systems and establish Europe as a leading scientific and industrial player in this field,
Impact Initially participating as a member of the action group
Start Year 2014
 
Description Fraunhofer IAPR - Research partnership for the packaging and supply of bare die ICs 
Organisation Fraunhofer Society
Department Fraunhofer Institute for Applied Polymer Research
Country Germany 
Sector Private 
PI Contribution Research partnership established to look at IC packaging and supply
Collaborator Contribution As above working on a research partnership for the packaging and supply of bare die ICs
Impact No reportable outcomes as yet
Start Year 2014
 
Description Harvard University - Research partnership for joint research 
Organisation Brigham and Women's Hospital
Country United States 
Sector Hospitals 
PI Contribution Joint research on the wireless power transfer topic
Collaborator Contribution Dr Sai Chun of Harvard Medical School collaborates on this joint research
Impact Joint research recently established no reportable outputs or outcomes as yet.
Start Year 2014
 
Description Roslin Institute, The Royal (Dick) School of Veterinary Studies, University of Edinburgh 
Organisation University of Edinburgh
Department Royal School of Veterinary Studies
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of devices to be tested in vivo by the Sonopill team, Roslin Institute provided of large animal facility for in vivo studies.
Collaborator Contribution Prof E Clutton of the Royal School of Veterinary Studies has presented at the Sonopill Monthly Meeting regarding animal testing and associated ethics (20160713). Discussion regards the development of a large animal disease model in discussion.
Impact Ongoing collaboration
Start Year 2016
 
Description Shenzhen Institute of Advanced Technology, China. 
Organisation Shenzhen University
Department Institute of Advanced technology
Country China 
Sector Academic/University 
PI Contribution Secondment of V Seetohul to Shenzhen Institute of Advanced Technology, China between 20161119-20161223.
Collaborator Contribution Talks at the IEEE-EMBS Shenzhen Chapter, 610th Academic Seminar on biomedical and health Engineering, Shenzhen, China. (20161206) and Hong Kong Polytechnic University, Departmental Seminar, Hong Kong.(20161219). Organisation of Shenzhen Rotatory Ultrasound Capsule to be tested in vivo at the Roslin Institute, University of Edniburgh. Perspective collaboration talks with Sonolepu, Shenzhen, China (20161202), CNIR Hurricane technology, Shenzhen, China (20161207) and SX Ultrasonics, Shenzhen, China (20161212).
Impact In vivo tests
Start Year 2016
 
Description Ultrasound in a needle for guidance in regional anaesthesia 
Organisation Royal Infirmary of Edinburgh
Country United Kingdom 
Sector Hospitals 
PI Contribution Collaboration on research into bonding technology
Collaborator Contribution Collaboration on research in placement of anaesthesia
Impact None applicable as yet, still active
Start Year 2015
 
Description Computer/Robot Assisted Surgery (CRAS), 6th Joint Workshop on New Technologies for Computer/Robot Assisted Surgery, Pisa. 20160912-20160914 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Sonopill: A Platform for Gastrointestinal Disease Diagnosis and Therapeutics. Talk presented by V Seetohul

Sonopill: A Platform for Gastrointestinal Disease Diagnosis and Therapeutics. G. Cummins, H. Lay, B.F. Cox, V. Seetohul, Y. Qiu, F. Stewart, J. Faerber, V. Mitrakos, M. Al Rawhani, J. Beeley, D.E. Watson, R. Poltarjonoks, C. Démoré, I. Nathke, R.J.C. Steele, D.Cumming, M.P.Y. Desmulliez, S. Cochran
Year(s) Of Engagement Activity 2016
URL https://www.cras-eu.org/organisation/Workshop/past-editions/proceedings/cras2016_proceedings
 
Description Conference Presentation - SonoCAIT: Sonication Capsule for Autonomous Imaging and Therapy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact Talk sparked questions and further discussion

N/A
Year(s) Of Engagement Activity 2015
 
Description Dundee Design Festival, Dundee City of Design. UNESCO. 20160525-20160528 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Dundee became the first UNESCO City of Design in the UK in November 2014, a prestigious award that recognises the huge contribution the city has made to design worldwide. he festival theme, 'Place. Work. Folk. Design' focused on design for health and wellbeing and explored the potential of design to connect communities and improve everyday lives. Sonopill was exhibited as part of the festival
Year(s) Of Engagement Activity 2016
URL http://sonopill.dundee.ac.uk/blog/fraser-stewart/sonozilla-dundee-international-design-festival-vipi...
 
Description Dundee Science Centre Meet the Researcher event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Schools visited the Science centre and met scientist from different areas who showed them examples of applied technology based on their discoveries.
Year(s) Of Engagement Activity 2019
 
Description Dundee Science Centre Sonopill Demonstration 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact 28.02.17 - Hands on demonstration of Sonopill at Dundee Science Centre event for visiting secondary school children from the wider area (Angus and Perthshire).
Year(s) Of Engagement Activity 2008,2017
 
Description EPSRC Science for a Successful Nation 2018 (London) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact We were invited by the EPSRC to showcase our pioneering work on magnetic guided capsule robots, alongside other Sonopill team members, at the historic Royal Society in central London. The aim of the event, entitled "Science for a Successful Nation," was to demonstrate the importance of long term investment in scientific research to an invited audience of influential policy makers, business leaders and leading UK academics. The day involved a number of key panel discussions on the EPSRC's strategy to facilitate research that promotes four prosperity outcomes, namely: a Productive nation, a Resilient nation, a Connected nation and a Healthy nation - ie. how can science and engineering support a longer-living, healthier society? In between talks, attendees had time to network and see firsthand some of the high impact research funded by the EPSRC. Visitors to our stand were able to see the KUKA medical robot in action, manipulating a capsule using a magnetic field, and also had the opportunity to see some of the other prototype devices from the project. Outcomes from the event included a broader network (connecting with other professionals). Current impacts are unknown.
Year(s) Of Engagement Activity 2018
URL http://www.epsrc.ac.uk/newsevents/news/sfsn2018/
 
Description ESPRC Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presented work with Sonopill team at EPSCR showcase event in London on 21.02.18. The EPSRC event is designed to promote the importance of EPSRC investments, in the context of UK prosperity. Our presentation was titled "Looking Inside Your Gut" which fell under the Healthy Nation category.
Year(s) Of Engagement Activity 2018
 
Description European Crohn´s and Colitis Organisation (ECCO) Confererence, 11th Congress of ECCO, Amsterdam 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact P030 Development of small bowel tissue phantom for microultrasound investigation. Poster presented by T Anbarasan.
Year(s) Of Engagement Activity 2016
URL https://www.ecco-ibd.eu/index.php/publications/congress-abstract-s/abstracts-2016/item/p030-developm...
 
Description Hong Kong Polytechnic University, Departmental Seminar, Hong Kong. 20161209 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Sonopill Research presented by V Seetohul
Year(s) Of Engagement Activity 2016
 
Description Hosting Art students in lab 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact 3rd year Jewellery students visited the lab and learned about our science and how we do it.
Year(s) Of Engagement Activity 2018
 
Description IEEE-EMBS Shenzhen Chapter, 610th Academic Seminar on biomedical and health Engineering, Shenzhen, China. 20161206 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Sonopill Research presented by V Seetohul
Year(s) Of Engagement Activity 2016
 
Description IGT+ Network Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Sonopill member M. Turcanu presented "Drug Delivery and Imaging for Enhanced Uptake in the GI Tract" at the IGT+ Network Meeting, University of Kent, February 2018.
Year(s) Of Engagement Activity 2018
 
Description Ingenious Women Project 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact 08.03.18 Guest speaker at Ingenious Women Event that took place in Dundee. The title of my talk was "Life and work on many coasts". This is a national networking event for the Enterprising & Ingenious Women Scotland programme. This networking event is open to all women of all career stages who are interested in reflecting on their careers and building their networks.
Year(s) Of Engagement Activity 2018
 
Description Institution of Engineering and Technology (IET) & Royal Society of Medicine RSM), The future of medicine; the role of the doctor in 2025. London 20160519 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Sonopill - Doctors' diagnostic tool of the future. Poster presented by V Seetohul.
Year(s) Of Engagement Activity 2016
URL https://www.rsm.ac.uk/events/events-listing/2015-2016/sections/telemedicine-ehealth-section/teg04-th...
 
Description International Ultrasonics Symposium (IUS). Tours, France. 20160918-20160921. Oral (19th) and Poster (21st) Presentations 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact An In Vitro Sonication System for Applications in Ultrasound-mediated Targeted Drug Delivery. Presented by F Stewart in Oral and Poster form.
Year(s) Of Engagement Activity 2016
 
Description Lecture about career in Science to Life Sciences UG students at Univeristy Dundee 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Career talk to UG students to inform them about ways to make choices, how to manage, share experiences.
Year(s) Of Engagement Activity 2019
 
Description Lecture at Professor Alan Clark Memorial Event and European Stem Cell Research Institute 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation of results and ongoing work relating to all awards
Year(s) Of Engagement Activity 2016
 
Description Medical Marvels show - Dundee Science Centre 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Medical Marvels Show - Dundee Science Centre Talking to high school students and demonstrating my work
Year(s) Of Engagement Activity 2018
 
Description Meet The Researchers, Aberdeen Science Centre 08032016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Sonopill members J Farber and BF Cox participated in the 'Meet the Researchers' event organised by Medical Research Scotland. Students from various schools across Scotland were given the opportunity to learn about concepts in gastrointestinal imaging and gain insight into the development of Sonopill.
Year(s) Of Engagement Activity 2016
 
Description Meet The Researchers, Dundee Science Centre 09032016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Sonopill members F Stewart and BF Cox participated in the 'Meet the Researchers' event organised by Medical Research Scotland. The event was held over at the Dundee Science Centre in March, 2016. Students from various schools across Scotland were given the opportunity to learn about concepts in gastrointestinal imaging and gain insight into the development of Sonopill. Pupils at the Dundee Science Centre were joined by the Princess Royale, patron of Medical Research Scotland
Year(s) Of Engagement Activity 2016
URL http://sonopill.dundee.ac.uk/public-engagement/meet-researcher-showcase-dundee
 
Description Meet The Researchers, Dundee Science Centre 28022017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Sonopill members I Nathke and J Farber participated in the 'Meet the Researchers' event organised by Medical Research Scotland. The event was held at the Dundee Science Centre in February 2017. Students from various schools across Scotland were given the opportunity to learn about concepts in gastrointestinal imaging and gain insight into the development of Sonopill.
Year(s) Of Engagement Activity 2017
 
Description Meet The Researchers, Glasgow Science Centre 01032017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Sonopill members F Stewart and MTurcanuparticipated in the 'Meet the Researchers' event organised by Medical Research Scotland. The event was held at the Glasgow Science Centre in March, 2017. Students from various schools across Scotland were given the opportunity to learn about concepts in gastrointestinal imaging and gain insight into the development of Sonopill.
Year(s) Of Engagement Activity 2017
 
Description Meet the expert 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Demonstrations to school children at the Science Centre about colonoscopy, bowel biology, ultrasound, etc.
Year(s) Of Engagement Activity 2017
 
Description Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Participation on UoD applicant day- aimed to attract UG offer holders to choose UoD as final choice
Year(s) Of Engagement Activity 2018
 
Description Open day for potential UG students 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Participation on UoD Open day - aimed to attract UG applications for 2019/2020
Year(s) Of Engagement Activity 2018
 
Description Presentation - Capsule-based Ultrasound-mediated Targeted Gastrointestinal Drug Delivery 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Participants in your research and patient groups
Results and Impact Talk sparked discussion and establishment of possible collaborative contacts

N/A
Year(s) Of Engagement Activity 2015
 
Description Presentation at Photonex Scotland Roadshow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation of work relating to numerous awards
Year(s) Of Engagement Activity 2016
 
Description Presentation at |Lumps and Bumps" meeting on cancer and placentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation to audience including medical and scientific practitioners presenting work relating to all awards
Year(s) Of Engagement Activity 2016
 
Description SET for Britain 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Capsule Endoscopy for Therapy in the Gastrointestinal Tract
Year(s) Of Engagement Activity 2016
URL https://medicine.dundee.ac.uk/news/fraser-stewart-takes-his-research-parliament
 
Description Scientific presentation about work relating to multiple awards at "Single Cell Biology" at the Genome Campus HInxton, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Scientific presentation about work sharing work related to multiple awards
Year(s) Of Engagement Activity 2016
 
Description Scottish Ultrasound Group, Annual Scientific Meeting. 20170308 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Investigation of LAMP-1 expression in cells treated with ultrasound and microbubbles as an indicator of cell membrane repair. Poster presented by M Turcanu.
Year(s) Of Engagement Activity 2017
 
Description Tayside Clinical Technology Workshop, University of Dundee School of Medicine and NHS Tayside. 20160429 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact A clinical multidisciplinary event bringing together physicians from a number of different specialties to examine the current state of the Sonopill technology development. We examined and critiqued the currently proposed modes of diagnosis and therapy, examined these modalities in other disciplines and invited further novel means of investigation and intervention. This workshop focused on exploring technology and its potential in solving issues encountered in day-to-day practice as identified by the clinicians themselves.
The workshop was organised into small interdisciplinary groups, with each group chaired by a peer with medical student assistance, working together to address the themes of the Sonopill technology for diagnosis and treatment in order to meet clinical needs and create engineering actionable ideas. The resulting ideas will be discussed at a follow-up engineering-based "clinical hackathon".
Year(s) Of Engagement Activity 2016
 
Description University of Dundee Enginneering Summer School 20160727 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Capsule Ultrasound Tattooing of Gastrointestinal Tissue with Fluorescent Material. Talk by BF Cox and F Stewart
Year(s) Of Engagement Activity 2016
 
Description University of Dundee Medical School Post Graduate Symposium 20160615 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Talk: Ultrasound Mediated Marking of Gastrointestinal Tissue with Fluorescent Material. Presented by BF Cox. Second Prize 1st year PhD tissue/dry lab presentations.
Year(s) Of Engagement Activity 2016
 
Description University of Dundee Medical School Post Graduate Symposium 20160615 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Poster: Capsule-based Ultrasound-mediated Targeted Gastrointestinal Drug Delivery. Presented by F. Stewart
Year(s) Of Engagement Activity 2016
 
Description University of Dundee School of Enginneering. Lecture 20170301 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Lecture on Clinical Imaging and Endoscopy in cluding elements on Sonopill. Presented by BF Cox
Year(s) Of Engagement Activity 2017
 
Description University of Dundee School of Life Sciences Internal Seminars 20161201 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Capsule based ultrasound mediated targeted drug delivery. Talk presented by F Stewart
Year(s) Of Engagement Activity 2016
 
Description Video prepared by Wellcome Trust related to facility in which Sonopill was tested 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The Wellcome Trust wished to publicise the success of the facility it supports at Dryden Farm, Roslin, Edinburgh. It funded the preparation of a short video describing the facility and how it had been used by the Sonopill programme.
Year(s) Of Engagement Activity 2019
URL https://wellc.me/2tBxom3