Core Capability for Chemistry Research - Strategic Investment in Mass Spectrometry
Lead Research Organisation:
University of Bristol
Department Name: Chemistry
Abstract
See Case for Support and Pathways to Impact
Planned Impact
Attached as separate document.
Organisations
Publications
Abas H
(2019)
Asymmetric and Geometry-Selective a-Alkenylation of a-Amino Acids.
in Angewandte Chemie (International ed. in English)
Abood A
(2015)
Kinetic characterisation of the FAD dependent monooxygenase TropB and investigation of its biotransformation potential
in RSC Advances
Abrams R
(2018)
Transition Metal Free Cycloamination of Prenyl Carbamates and Ureas Promoted by Aryldiazonium Salts.
in Angewandte Chemie (International ed. in English)
Ackrill T
(2015)
Synthesis of Diarylheptanoid Scaffolds Inspired by Calyxins I and J
in Organic Letters
Adam C
(2018)
The Role of Terminal Functionality in the Membrane and Antibacterial Activity of Peptaibol-Mimetic Aib Foldamers.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Aggarwal V
(2015)
Palladium-Catalyzed Reactions of Allylic Boronic Esters with Nucleophiles: Novel Umpolung Reactivity
in Synlett
Aggarwal VK
(2014)
Comprehensive Organic Synthesis II
Aichhorn S
(2017)
Enantiospecific Synthesis of ortho-Substituted Benzylic Boronic Esters by a 1,2-Metalate Rearrangement/1,3-Borotropic Shift Sequence.
in Journal of the American Chemical Society
Al Fahad A
(2014)
The biosynthesis and catabolism of the maleic anhydride moiety of stipitatonic acid.
in Angewandte Chemie (International ed. in English)
| Description | The new instruments within the Mass Spectrometry Facility now allow in-depth analysis of complex mixtures, the ability to examine the interactions of molecules with other species such as in inorganic complexes or protein-drug complexes, as well as the analysis of high molecular weight species, such as polymers and proteins. The acquisition of these new instruments has allowed us to significantly advance our understanding of specific chemical reactions, as well as to analyze in detail synthetic approaches to naturally occurring scaffolds, which have the potential to lead to novel therapeutic compounds. Cyclohexane based anion carriers are being designed and synthesized, which may have the potential for channel replacement therapy in cases of cystic fibrosis, synthetic scaffolds are finding applications as medicinal sensors, while rationally designed porous solids are a potential solution to the gas storage problem. The properties of non-proteinogenic amino acids are also of interest, especially those features, which make them suitable for the study of Alzheimer's disease. Scaffolds are being designed with the purpose of supporting cell or tissue growth, enzymes are being rationally developed to act as specific catalysts, while compounds that can mimic biological boundaries could be used as protocells for drug delivery. |
| Exploitation Route | Findings from mass spectrometric analyses carried out will advance mechanistic understanding which will enable the production of new materials. The rational design of compounds which may play a role in energy harvesting and storage, or which may act as drugs with potential healthcare uses will also stimulate research both within academia as well as industry. We are training the current cohorts of PhD students from the Centres for Doctoral training as well as post doctoral researchers within individual groups. These students may eventually progress to senior positions in academia or industry. Output from the MS facility is also being used in undergraduate teaching as well as outreach events with the aim of inspiring the next generation of chemists. |
| Sectors | Chemicals,Education,Energy,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Description | Chemistry departments within UK universities make significant contributions to worldwide societal challenges through impacts based in drug discovery, energy and new materials. The School of Chemistry at the University of Bristol is an acknowledged leader in synthesis, materials and supramolecular chemistry, as well as chemical biology and research groups are working towards the production of bioactive compounds, polymeric materials and surfactants with applications in energy harvesting and storage, as well as on synthetic receptors with future healthcare potential. Cutting-edge analytical equipment underpins progress in all of these research areas and impacts arising from investment in Mass Spectrometry will broadly fall into four groups: in industry and academia as well as on the general public and society. |
| First Year Of Impact | 2013 |
| Sector | Chemicals,Education,Energy,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Cultural,Societal,Economic |
| Description | ABEL |
| Amount | € 2,467,844 (EUR) |
| Funding ID | LS9,ERC-2013-ADG |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 02/2014 |
| End | 01/2019 |
| Description | AMR Collaborative grant - Exploring Nature's Silent Pharmacy |
| Amount | £2,400,000 (GBP) |
| Funding ID | MR/N029909/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 09/2020 |
| Description | BIOMOLECULAR ORIGAMI |
| Amount | £333,189 (GBP) |
| Funding ID | BB/M005615/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2014 |
| End | 08/2017 |
| Description | BP/EPSRC iCASE: Analysis of complex petrochemical deposits. |
| Amount | £80,670 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 12/2019 |
| Description | Cobalt- and Nickel-based Polymetallocenes: Functional Metallopolymers from Earth-Abundant Metals |
| Amount | £263,683 (GBP) |
| Funding ID | EP/N030702/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 09/2018 |
| Description | Dynamic communication through reorganisable hydrogen bond networks |
| Amount | £195,989 (GBP) |
| Organisation | The Leverhulme Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2016 |
| End | 03/2019 |
| Description | EPSRC Centre for Doctoral Training in Chemical Synthesis |
| Amount | £5,268,179 (GBP) |
| Funding ID | EP/L015366/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2014 |
| End | 09/2022 |
| Description | EPSRC Centre for Doctoral Training in Functional Materials: The BCFN |
| Amount | £4,553,545 (GBP) |
| Funding ID | EP/L016648/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2014 |
| End | 09/2022 |
| Description | ERC FRESCO |
| Amount | € 2,500,000 (EUR) |
| Funding ID | 670668 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 10/2015 |
| End | 10/2020 |
| Description | Factory in a Fumehood: Reagentless Flow Reactors as Enabling Techniques for Manufacture |
| Amount | £940,746 (GBP) |
| Funding ID | EP/L003325/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2013 |
| End | 02/2017 |
| Description | Fellowship David Tilly |
| Amount | £121,492 (GBP) |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 10/2016 |
| End | 09/2019 |
| Description | Impact acceleration |
| Amount | £68,205 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 03/2017 |
| Description | LoLa |
| Amount | £3,484,653 (GBP) |
| Funding ID | BB/M002969/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2014 |
| End | 09/2019 |
| Description | Longer and Larger Grants |
| Amount | £3,500,000 (GBP) |
| Funding ID | BB/K002341/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2013 |
| End | 07/2018 |
| Description | MRC CiC, Cancer Research Technology and Guy Newton Translational Grant. IGF2-TRAP development. |
| Amount | £130,424 (GBP) |
| Funding ID | BRR00040 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 07/2017 |
| Description | Natural Product Leads to Selective Fungicides and Herbicides |
| Amount | £96,696 (GBP) |
| Funding ID | BB/P504804/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 09/2020 |
| Description | Nicotinic Ligand Development to Target Smoking Cessation and Gain a Molecular Level Understanding of Partial Agonism |
| Amount | £724,553 (GBP) |
| Funding ID | EP/N024117/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2016 |
| End | 05/2019 |
| Description | Optoelectronic Nanostructures via Polythiophene Block Copolymer Self-Assembly |
| Amount | £544,263 (GBP) |
| Funding ID | EP/K017799/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2013 |
| End | 03/2017 |
| Description | Photo-Electro: Transforming Chemical Synthesis, Discovery and Manufacture |
| Amount | £6,486,390 (GBP) |
| Funding ID | EP/P013341/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2017 |
| End | 02/2022 |
| Description | Protolife-inspired materials chemistry |
| Amount | £675,541 (GBP) |
| Funding ID | EP/L002957/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2014 |
| End | 06/2017 |
| Description | Quaternary amino acids on scale for medicine and agroscience |
| Amount | £104,109 (GBP) |
| Funding ID | 727296 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 09/2016 |
| End | 03/2019 |
| Description | SAGE |
| Amount | £731,565 (GBP) |
| Funding ID | BB/L010518/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2014 |
| End | 06/2017 |
| Description | Synthesis and Biology of Prostanoids |
| Amount | £1,061,277 (GBP) |
| Funding ID | EP/M012530/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2015 |
| End | 04/2020 |
| Description | Synthetic Biology |
| Amount | £13,528,180 (GBP) |
| Funding ID | BB/L01386X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2014 |
| End | 06/2019 |
| Description | The Ironworks: a mechanistic foundry for iron-catalysed cross-coupling |
| Amount | £630,649 (GBP) |
| Funding ID | EP/K012258/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2013 |
| End | 07/2017 |
| Description | alpha-Arylation and alpha-Vinylation of Enolates: New Reactivity from the Urea Linkage |
| Amount | £231,446 (GBP) |
| Funding ID | EP/L018527/2 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2015 |
| End | 05/2017 |