A paradigm shift in low-field NMR spectroscopy for industrial process monitoring, control, and optimisation

Lead Research Organisation: University of York
Department Name: Chemistry

Abstract

We are all familiar with the concept of travel, and visiting York from Glasgow is conceptually a trial matter. When we reflect on this process, however, there are lots of potential questions we might ask about the mode of transport, the route and the potential to get lost.
A similar range of questions could be asked about chemical reactions. We select starting materials and seek to transform them into products. The route we choose is equally complex. Now, however, the participants are much smaller and very special methods are needed to view them. Furthermore, with an optimal solution we get the most product from the least starting material using the least amount of energy and other resources as possible. If think of a reaction that is undertaken on the 1,000,000 tonne scale it is also clearly vital to minimise waste.
In Chemistry, there is a very special and often expensive method called nuclear magnetic resonance spectroscopy (NMR) that allows us to take pictures of the participants as they travel from starting materials to products. This methods is normally very insensitive and hence very expensive large magnets are required. If we want to use this technology to deliver clean and efficient chemistry on an industrial scale we need to find a way to work with smaller lower cost magnets, ideally using the Earth's magnetic field. In this project we aim to develop a new method using such low-magnetic field NMR devices to follow the route taken by molecules during their conversion into high value products in both laboratory and industrial settings. We will use a special form of hydrogen gas, known as parahydrogen to increase the sensitivity of the NMR measurement to a level that will allow to achieve this goal. Parahydrogen was actually the fuel of the space shuttle and one might view it here as acting like a molecular microscope whilst at the same time removing (filtering) any unwanted signals from spectators to the reaction of interest. We will build-up our understanding of the reactions route by taking our NMR pictures which contains precise information about the identity of the participants (molecules) at different times after the start of the reaction. This means that we will monitor the same process several times in order to produce the necessary molecular level picture that will ultimately allow us to optimise our chosen reaction. The enhanced level of information that will be provided by our new device will enable scientists and industrialists to develop and optimise reactions in a way that was previously impossible and hence contribute more positively to society.

Planned Impact

The project is of relevance to areas of strategic importance as identified by the research councils (critical (c) to supportive (s)): analytical science (c), catalysis (c), chemical reaction dynamics and mechanisms (c), chemical structure (c), computational and theoretical chemistry (s), sensors and instrumentation (c) and synthetic coordination chemistry (c). Its unprecedented approach will see the power of NMR used to provide valuable insights that have relevance to both environmental sustainability (via catalysis) and UK Plc.
It is the opportunity to improve existing processes and to also develop new manufacturing processes, e.g. novel intensified and continuous, through laboratory and plant scale measurements that will secure cost-savings and efficiency gains. This will be achieved in conjunction with the CPI, which is the process element of the UK government funded 'High Value Manufacturing Catapult' network. CPI works with academics and SMEs to translate a broad range of technologies in industrial biotechnology, smart chemistry, anaerobic digestion, sustainable engineering and biologics manufacture. In addition, engagement with members of CPACT, who represent a broad spectrum of industrial interest, will maximise the utilisation of the new technology. Julian Morris of Morris Associates, in his capacity as CPACT Technical Director, will provide a key link between academia and industry to ensure dissemination of the research and promotion of the technology within industry. A steering group will be set-up, which will be chaired by an industrial representative, to ensure that the technology developed meets the needs for manufacturing across a range of sectors. Company representatives will attend project meetings, provide input on design criteria and help with benchmarking of the prototype technology. In the second route to economic impact, this project offers the opportunity to support the UK supply chain in advanced instrumentation and research equipment. This would be achieved through the development of novel instrumentation by formal collaboration with either Bruker-BioSpin, Oxford Instruments or Magritek Limited.
Our chosen approach using parahydrogen is unique and will serve as a model from which to work to revolutionise the potential of NMR to study reactions. There has been a huge research investment in the development of hyperpolarisation methods aligned to healthcare in both the USA and Europe over the last decade; York has world leading expertise here and spin-offs into this area are expected. The potential for this work to manifest itself directly in health in the future is therefore not unrealistic.
The applicants have substantial previous experience in collaborating with commercial companies and have attracted recent support through industrial CASE awards. Support for patent protection, IP management and commercialisation is provided by our Universities Research and Enterprise Offices. Once any patent protection issues have been resolved, the results obtained will be presented at national and international conferences and during visits to universities and industrial research centres. The investigators will seek further collaborations with potential users of the technology. They will attend relevant conferences and have given invited/keynote lectures at such conferences. Most importantly, the results will be published as communications in leading international journals, followed by full papers, which include further studies. The investigators will develop their webpages to disseminate and showcase the results obtained and, if appropriate, will work with the Departmental and University press officers. In addition to communicating with other researchers in the field, it is very important to inform the public. The applicants have published general science articles and given public lectures. We will extend these and related outreach activities.

Publications

10 25 50
 
Description We have established that it is possible to track chemical change at low field using hyperpolarised NMR. This is hard to achieve using these low cost devices because their sensitivity is poor. The methods developed have established that it is possible to improve on the level of response by factors that exceed 1000 times in many cases. This enables the low-cost system to make measurements that would have previously only be possible using a far more expensive NMR-camera. A number of devices have been built to help transport the sample into the device to achieve this.
A paper was published in Magnetic Resonance in Chemistry (P. M. Richardson, S. Jackson, A. J Parrott, A. Nordon, S. B. Duckett, M. E. Halse, A simple hand-held magnet array for efficient and reproducible SABRE hyperpolarisation using manual sample shaking, Magnetic Resonance in Chemistry, 2017, DOI: 10.1002/mrc.4687). A PhD studentship was funded by Pfizer (Olga Semenova). Presentations have been given at several analytical and CPACT meetings by members of the team to share good practice.
Further papers have now been published: SABRE hyperpolarisation enables high-sensitivity 1H and 13C benchtop NMR spectroscopy
P. M. Richardson, A. J Parrott, O. Semenova, A. Nordon, S. B. Duckett, M. E. Halse, Analyst, 2018, 143, 3442-3450. DOI: 10.1039/C8AN00596F; Quantitative In-situ Monitoring of Parahydrogen Fraction Using Raman Spectroscopy A. J. Parrott, P. Dallin, J. Andrews, P. M. Richardson, O. Semenova, M. E. Halse, S. B. Duckett, and A. Nordon, Applied Spectroscopy, 2018 (in press) DOI: 10.1177/0003702818798644;
Quantification of hyperpolarisation efficiency in SABRE and SABRE-Relay enhanced NMR spectroscopy
P. M. Richardson, R. O. John, A. J. Parrott, P. J. Rayner, W. Iali, A. Nordon, M. E. Halse, and S. B. Duckett, Physical Chemistry Chemical Physics, 2018, 20, 26362-26371. DOI: 10.1039/C8CP05473H.
Since the last report we have added two further papers as outputs to this award.
P. M. Richardson, W. Iali, S. S. Roy, P. J. Rayner, M. E. Halse, and S. B. Duckett, Rapid C-13 NMR hyperpolarization delivered from para-hydrogen enables the low concentration detection and quantification of sugars. Chemical Science. 2019, 45, 10607-10619.
O. Semenova, P. M. Richardson, A. J. Parrott, A. Nordon, M. E. Halse and S. B. Duckett. Reaction Monitoring Using SABRE-Hyperpolarized Benchtop (1 T) NMR Spectroscopy. Analytical Chemistry. 91, 10, 6695-6701.
These have demonstrated how a reaction can be studied at 1T, and that the rapid quantification of glucose is possible through a 13C signal.

These underpin developments in low field NMR and will be augmented by further publications shortly.
Exploitation Route We expect industry to engage with the technology as it develops to improve their ability to assess the performance of industrial processes.
Sectors Chemicals

URL https://www.york.ac.uk/chym/
 
Description We are about to start working with Pfizer on a study of some of their systems. This has been delayed due to COVID.
Sector Chemicals
Impact Types Economic

 
Description EPSRC IAA Researcher Mobility Grant
Amount £2,247,310 (GBP)
Funding ID EP/R51181X/1 
Organisation University of York 
Sector Academic/University
Country United Kingdom
Start 04/2017 
End 03/2022
 
Description New Investigator Award
Amount £210,439 (GBP)
Funding ID EP/R028745/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 08/2018 
End 07/2020
 
Title Data for: "Low-field high-resolution PFG-NMR to predict the size distribution of inner droplets in double emulsions" 
Description This dataset contains the NMR data used for the publication "Low-field high-resolution PFG-NMR to predict the size distribution of inner droplets in double emulsions". It contains the following files: NMRrawdata.7z the raw 1H PFG-NMR data acquired using PGSTE pulse sequence using Magritek Spinsolve 1 T. Within 7z file data is arranged into folders which are named by the experimental ID (1 to 10). The NMR signal is recorded within the PGSEData.2d file located within each experimental folder. Each folder also contains an acqu.par file which contains all NMR experimental parameters/settings. keywunits.csv contains the meta information for experimental IDs within NMRrawdata.7z indicating the sample and parameters changed within each experiment, as well as a list of which figures these results are used for within the publication. exportdata.csv contains experimental ID, gradient power (in T/m) and integrated water signal (from the NMR data) for each gradient power, and is the data used for calculations and figures presented in the the publication. 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
URL https://pureportal.strath.ac.uk/en/datasets/e5c7d5ba-8e84-41ce-984d-d9a8fbac4636
 
Title Data for: "Quantitative In-situ Monitoring of Parahydrogen Fraction Using Raman Spectroscopy" 
Description Raman spectra, NMR spectra, and various calculation results used for article "Quantitative In-situ Monitoring of Parahydrogen Fraction Using Raman Spectroscopy". RawDataFile.7z contains all of the raw Raman and NMR spectra used in the work. calcs2genfigs.7z contains summary data files (e.g. Raman peak intensity Vs time) for each experiment in .RDS format, it also contains the R scripts used to generate all the figures and tables in the paper. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
 
Title New hand-held magnet array for improved manual SABRE hyperpolarisation 
Description A new device for improving the efficiency and reproducibility of the SABRE NMR hyperpolarisation technique was developed. This allows the manual SABRE hyperpolarisation technique to be used with low-cost benchtop NMR spectrometers that, unlike many expensive high-magnetic-field spectrometers, do not have appreciable magnetic fields outside of the main instrument. 
Type Of Technology Systems, Materials & Instrumental Engineering 
Year Produced 2017 
Impact This device is used with the Centre for Hyperpolarisation in Magnetic Resonance (CHyM) to provide more consistent and reproducible experimental conditions for carrying out the SABRE (signal amplification by reversible exchange) hyperpolarisation technique using manual sample shaking. This leads to the observation of larger NMR signal enhancements and a higher level of reproducibility between experiments. 
 
Description 4th International Metabolic Imaging Workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A presentation on parahydrogen based methods to improve NMR and MRI
Year(s) Of Engagement Activity 2016
 
Description Article in the daily mail 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Potential for hyperpolarisation to transform MRI
Year(s) Of Engagement Activity 2018
 
Description BBC the one show 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Presentation to celebrate the life of Sir Peter Mansfield; input into the future of MRI
Year(s) Of Engagement Activity 2018
 
Description CPACT Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Workshop detailing potential routes to use hyperpolarisation to aid in industrial production
Year(s) Of Engagement Activity 2016
 
Description CPACT webinar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Centre for Process Analytical and Control Technology (CPACT) webinar on hyperpolarised benchtop NMR spectroscopy.
Year(s) Of Engagement Activity 2017
 
Description Dalton Discussion Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact A research talk on the use of parahydrogen enhanced NMR methods for cataysis
Year(s) Of Engagement Activity 2016
 
Description Department of Physics, University of New Brunswick, Fredericton NB Canada (October 13, 2016) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk, departmental, Meghan Halse
Year(s) Of Engagement Activity 2016
 
Description Discussion Magritek 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Aim to establish a commercial partnership
Year(s) Of Engagement Activity 2016
 
Description Domino Printing Inks Visit 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact A presentation was given on the potential of SABRE as a tool to aid in the analysis of printing ink solutions
Year(s) Of Engagement Activity 2017
 
Description Exxon Research Centre 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Aim to illustrate the industrial potential for hyperpolarisation
Year(s) Of Engagement Activity 2016
 
Description Huddersfield Hyperpolarisation Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Series of presentations detailing aspects of hyperpolarisation
Year(s) Of Engagement Activity 2016
 
Description Invited presentation at SciX 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation titled: "Process Monitoring with Hyperpolarised NMR Spectroscopy" - at SciX 2017 (Reno, USA) 2017-10-08.
Year(s) Of Engagement Activity 2017
 
Description Invited speaker - Christmas meeting of the RSC NMR discussion group 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited presentation to the national NMR community as part of the Royal Society of Chemistry NMR DIscussion group annual Christmas meeting.
Year(s) Of Engagement Activity 2018
URL http://www.nmrdg.org.uk/
 
Description Invited speaker - Institute of Physics BSRG Christmas meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited lecture at a one-day meeting of the BSRG (the magnetic resonance group) of the Institute of Physics.
Year(s) Of Engagement Activity 2019
URL https://www.iopconferences.org/iop/frontend/reg/tOtherPage.csp?pageID=854297&eventID=1370
 
Description Invited speaker at Hyperpolarisation in Magnetic Resonance conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I was an invited speaker at the international conference on Hyperpolarisation in Magnetic Resonance. This was an international conference attended by ~200 participants including academics, researchers, industrialists and graduate students.
Year(s) Of Engagement Activity 2018
URL http://generic.wordpress.soton.ac.uk/hyp18
 
Description Invited speaker at PANIC Industrial applications of NMR conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact I was invited to speak about my work on hyperpolarised low-cost and portable NMR spectroscopy at PANIC 2019 (Practical Applications of NMR in Industry Conference).
Year(s) Of Engagement Activity 2019
URL https://www.panicnmr.com/
 
Description Invited speaker at the National Congress on Magnetic Resonance of the Gruppo Italiano Discussione Risonanze Magnetiche (GIDRM) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker at the National Congress on Magnetic Resonance of the Gruppo Italiano Discussione Risonanze Magnetiche (GIDRM) in Salerno, Italy. Presented recent work in a talk entitled: "Hyperpolarised low-field NMR spectroscopy".
Year(s) Of Engagement Activity 2017
 
Description Invited talk at the Zero-to-ultra-low-field (ZULF) NMR international conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited talk at the 1st international ZULF conference, which was held online due to the pandemic.
Year(s) Of Engagement Activity 2020
URL https://www.conference.zulf.eu/
 
Description Invited talks at the Parahydrogen Enhanced Resonance (PERM) online conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact invited research presentation at an online conference with an international audience.
Year(s) Of Engagement Activity 2020
URL https://www.perm-conference.org/
 
Description Local Workshop for EUROPOL (ITN) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact A workshop on hyperpolarisation methods based on parahydrogen.
Year(s) Of Engagement Activity 2016
 
Description MRC Hyperpolarised MRI workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Workshop to consider progress in hyperpolarisation that will lead to clinical use
Year(s) Of Engagement Activity 2015
 
Description NMR discussion group meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Local organiser and speaker at a meeting focussed on low field NMR
Year(s) Of Engagement Activity 2016
 
Description NMR outreach workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact To establish a remit to develop an outreach activity related to NMR
Year(s) Of Engagement Activity 2016
 
Description Opening National Centre of Hyperpolarised MRI 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Scientific talk on developments in SABRE hyperpolarisation.
Year(s) Of Engagement Activity 2016
 
Description Oral presentation at NMRDG Post-graduate meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Oral presentation entitled: "Single-shot hyperpolarisation lifetime measurements for monitoring reactivity by benchtop NMR" at the 10th annual NMR Discussion Group Postgraduate Meeting (Royal Society of Chemistry).
Year(s) Of Engagement Activity 2017
URL http://www.nmrdg.org.uk/Meetings/Summer2017/PG%20Meeting%20Report%202017.pdf
 
Description Organizer and Host of the first UK Magritek Benchtop NMR User's Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Organised and Hosted a one-day meeting at the University of York to bring together UK-based users of the benchtop NMR spectroscopy technology of Magritek Limited. In coordination with the vendor (Magritek Limited), the meeting brought together users from industry and academia for a series of talks, panel discussions and networking opportunities.
Year(s) Of Engagement Activity 2019
 
Description Pfizer visit to explore collaborative opportunities 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Visit to Pfizer on 4 April 2017 and series of talks to explore potential areas of collaboration.
Year(s) Of Engagement Activity 2017
 
Description Pfizer webinar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Webinar to update researchers within Pfizer on our work on hyperplarised benchtop NMR spectrosocpy with a view to developing further collaboration.
Year(s) Of Engagement Activity 2017
 
Description Presentation at CPACT research Day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Oral presentation on SABRE hyperpolarised benchtop NMR at the Centre for Process Analytical and Control Technology (CPACT)
Year(s) Of Engagement Activity 2017
 
Description Presentation at University of Strathwide 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Presentation titled: "Increasing the sensitivity of Benchtop NMR with Hyperpolarisation" at Strathwide 2017 (Strathclyde University, Glasgow, UK), May 30, 2017
Year(s) Of Engagement Activity 2017
 
Description Progress Meeting with presentation (CPACT) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A presentation on SABRE and low-field study was given
Year(s) Of Engagement Activity 2016
 
Description Progress With Parahydrogen 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk to Pfizer
Year(s) Of Engagement Activity 2018
 
Description Research Talk (Rochester) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Research Talk
Year(s) Of Engagement Activity 2016
 
Description Seminar Programme 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Series of seminars in Strasbourg related to hyperpolarisation
Year(s) Of Engagement Activity 2018
 
Description Series of talks based on award of RSC Tilden Prize 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Three talks were given to illustrate future opportunities for MRI and NMR based on our scientific developments at Aston, Durham and Southampton
Year(s) Of Engagement Activity 2019
 
Description Sir Peter Mansfield Imaging Centre, Nottingham University, Nottingham UK (March 9, 2017) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Policymakers/politicians
Results and Impact Departmental Talk.
Year(s) Of Engagement Activity 2016
 
Description Speaker at 20th International Society of Magnetic Resonance (ISMAR) Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Contributed talk at the 20th International Society of Magnetic Resonance (ISMAR) Meeting in Quebec City, Canada.
Year(s) Of Engagement Activity 2017
 
Description Speaker at the International Conference on Magnetic Resonance Microscopy (ICMRM) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented a talk entitled: "Hyperpolarised Benchtop NMR for Industrial Applications" at the International Conference on Magnetic Resonance Microscopy (ICMRM) in Halifax, Nova Scotia, Canada.
Year(s) Of Engagement Activity 2017
 
Description Talk Cambridge Synthesis and Applications of Labelled Compounds 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk within international meeting
Year(s) Of Engagement Activity 2016
 
Description Talk Hyperpolarisation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Talk as part of a prize symposium
Year(s) Of Engagement Activity 2016
 
Description Talk at GSK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact talk and tour at GSK to explore collaboration possibilities
Year(s) Of Engagement Activity 2017
 
Description Talk at Small Molecule NMR Conference (SMASH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation on reaction monitoring using SABRE hyperpolarised NMR spectroscopy at SMASH NMR conference in Baveno, Italy.
Year(s) Of Engagement Activity 2017
 
Description Talk on progress with parahydrogen 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk with GSK
Year(s) Of Engagement Activity 2018
 
Description Talk on progress with parahydrogen 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact talk with scientists at AstraZeneca
Year(s) Of Engagement Activity 2018
 
Description Talk, Department of Chemistry, Iowa State University, Ames, Iowa, USA (September 23, 2016) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Departmental talk, Meghan Halse
Year(s) Of Engagement Activity 2016
 
Description Talk, FACSS SciC Conference, 18/09/16-23/09/16, Minneapolis MN, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact FACSS SciC Conference, 18/09/16-23/09/16, Minneapolis MN, USA, Meghan Halse
Year(s) Of Engagement Activity 2016
 
Description Using SABRE to improve NMR and MRI 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk given in Paris
Year(s) Of Engagement Activity 2016
 
Description Visit and presentations at CPI 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact A series of presentations on the state-of-the-art of SABRE hyperpolarisation and benchtop NMR spectroscopy in order to explore potential areas of collaboration.
Year(s) Of Engagement Activity 2017
 
Description Wellcome Trust Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact To inform on progress towards the clinical uptake of SABRE
Year(s) Of Engagement Activity 2016
 
Description York Hyperpolarisation Symposium (2 Day) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Series of 20 talks over 2 days
Year(s) Of Engagement Activity 2016
 
Description keynote presentation that I gave at APACT 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact 'Advances in process NMR spectrometry', talk given by A. Nordon,
as part of the Advances in Process Analytics and Control Technology meeting, Chester, UK, 20-26 April, 2016.
Year(s) Of Engagement Activity 2016
 
Description presentation at EuroPACT 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation titled: "Enabling Benchtop NMR Process Monitoring with Hyperpolarisation" - at EuroPACT 2017, 4rd European Conference on Process Analytics and Control Technology (Potsdam, Germany) 2017-05-10.
Year(s) Of Engagement Activity 2017
 
Description talk at IFPAC Annual Meeting 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact presentation on hyperplarised benchtop NMR for industrial applications at the 2017 IFPAC Annual Meeting in the USA
Year(s) Of Engagement Activity 2017