Bridging the Gaps: Systems-level approaches to antimicrobial resistance

Lead Research Organisation: University of Nottingham
Department Name: Sch of Mathematical Sciences

Abstract

The problem of antimicrobial resistance (AMR) is an increasing challenge, not only in the context of healthcare but also in, for example, food safety and agriculture. The prevalence of resistant bugs such as MRSA has received widespread media coverage and the problems relating to resistance are now more widely recognised than ever before, as is the importance of developing new approaches, particularly given the increase in issues associated with multidrug resistant species. The current proposal seeks to drawn on wide-ranging applicable expertise in engineering and the physical sciences that, in collaboration with biological-science researchers, clinicians and industry, offers hitherto unexploited opportunities to contribute significantly to addressing these very significant challenges.

We shall accordingly deliver a programme of activities that promotes new interdisciplinary collaborations across traditional boundaries between engineering, the physical sciences and the biological sciences. The University of Nottingham has an outstanding history of such discipline-bridging activities, as well as of research relevant to AMR, and will bring this experience to bear upon the challenge of AMR.

The primary mechanism for promoting new research collaborations will be that of themed Sandpits, building on the success of the Mathematics-in-Medicine Study Groups pioneered by the University in 2000 (and subsequently spawning the Mathematics-in-the-Plant-Sciences Study Groups and others). In these, presenters from the biological sciences, clinical medicine or industry will describe issues that could benefit from new approaches drawn from engineering and the physical sciences; intensive brain-storming work on these topics will identify the skills needed and establish the relevant cross-disciplinary teams; seed funding will then be provided for the most promising projects identified. While the process is now well-established, the outcomes of such workshops are very far from predictable and the aggregation of the range of disciplines outlined above should ensure that innovative approaches come to the fore. Other mechanisms will include Challenge Days (modifying the successful approach of the Industry Challenge Days held by the Business School to ensure that research developments align with the needs of potential end users), discipline-hopping secondments, speed-networking sessions, cross-disciplinary workshops (focussing on specific methodologies, to enhance further the opportunities for identifying potential crossovers between research fields) and annual showcases in the form of a launch event and a concluding 'forward-look' workshop. These activities will be augmented by a Visiting-Scholar programme whereby leading experts in complementary areas will contribute their expertise to the initiative.

Funding from the programme will be assigned in competition to multidisciplinary projects judged on their research excellence and their capacity to contribute to addressing AMR challenges. The programme's Strategy Group will be responsible for assessing applications and for monitoring progress; the activities outlined above are specifically designed (in particular by bringing together researchers from diverse disciplines) to ensure that the research ideas developed are highly innovative and that the associated projects have the required mix of research expertise. The programme will be very explicitly outward-facing, drawing extensively on input from clinicians, industrialists and other potential end users, as well as interacting with complementary research elsewhere. In combination with the excellence and innovation of the research developed, such collaborations will ensure the sustainability of the initiative.

Planned Impact

The work in this programme, and that subsequently pursued as a consequence of the developments that it enables, have the scope to impact in numerous contexts, including in advancing diagnostic and therapeutic capabilities of clinicians, in improved understanding of environmental factors, in associated developments of interest to a range of industries and in a greater public awareness of factors that contribute to antimicrobial resistance (particularly in perhaps less understood areas such as overuse in farming practices). Such impacts will produce a variety of benefits.

1. Economic benefits - for example to the pharmaceutical industry with respect to improved treatments (for example in new targets, better understanding of the pathways, improved delivery), to medical-device companies (such as through developing improved antimicrobial coatings for medical devices) and to the farming industry (notably in terms of improved procedures for disposal and decreased reliance on antibiotics for livestock feed).

2. Social benefits - any advances in tackling the AMR challenge would have positive effects on society, in particular education over misuse and disposal of antibiotics and on key issues that are less publicised such as understanding the importance of the setting (environmental factors).

3. Health benefits - better diagnostics would allow the more rapid detection and appropriate treatment of antimicrobial-resistant infections and the development of better understanding would lead to more effective treatments, as well as ones less likely to increase the spread of resistance. Such impacts will be of benefit not just to human health: there are broader implications for animal health that should be enhanced through work with the School of Veterinary Medicine and Science, with the University Farm and with water companies and other organisations involved in waste disposal.

4. Environmental benefits - improvements in the disposal of antibiotics and in the treatment of water and waste post-disposal would bring about a number of environmental benefits, for example in water cleanliness and soil quality. Decreasing reliance on antibiotics in livestock farming would also contribute to a healthier environment.

Publications

10 25 50

publication icon
B.W. Stuart (2018) Gallium incorporation into phosphate based glasses: Bulk and thin film properties in Journal of the Mechanical Behavior of Biomedical Materials

publication icon
K.M. Zakir Hossain (2018) Porous calcium phosphate glass microspheres for orthobiologic applications in Acta Biomaterialia

 
Description The events and funding opportunities have instigated and funded novel research and, most significantly, this research is already impacting on the treatment of AMR in farms and hospitals. For example, our researchers are informing farmers and government agencies on how to treat farm slurry and the causes of AMR spread, and beginning to help the NHS reduce surgical infection with a newly developed toolkit. Promising research continues on the development of novel antimicrobial drugs, stopping microbes from strengthening themselves by forming biofilms, creating 'point of care' GP tests for bacterial infections, and exploring potential alternatives to antibiotics such as quorum sensing. Relationships have been built with NHS colleagues, veterinary clinicians, policymakers and industrial partners, allowing our research efforts to be well-informed and impactful for the general population. A number of these are new or deepened industrial collaborations that cannot currently be discussed due to confidentiality agreements. Internally, the grant has resulted in a large number of new collaborations and new research groups, creating a step change in the research practices in antimicrobial resistance across the institution with cross-disciplinary, cross-site, research becoming the norm. The grant also supported early career researchers with event opportunities and pump prime grants that allowed them access to expertise and funding that can be difficult to access during the early career stage, helping to incentivise researchers to work in this essential area. As the majority of the projects that were funded were proof of concept it will take some time for all of the impacts to be fully realised but the grant was successful in meeting all of its award objectives and instigating a large number of new research questions and opportunities.
Exploitation Route New techniques, tools and datasets have been developed that are all relevant for further scientific enquiry. As noted above, some of the pump prime projects are already exhibiting impact and many developments e.g. those in POC devices, treatment of animal bedding, are likely to have further direct impacts on patients, treatment of animals, best economic options for farmers and animal health, behaviour of the general public etc. The majority of the research findings will be put to use by a collaborative team formed of researchers and farmers/clinical staff/industrial partners/government agencies etc. Such links were put in place early, often before pump prime funding/match funding was made available, meaning that the partners helped to define the research projects from the concept stage, and there is already interest and understanding from the relevant sector in how the research might be put to use. Project teams are currently in the process of applying for further funding or completing additional project work to support further funding applications. Some research, such as the development of potential antimicrobials and fundamental work on quorum sensing to alter bacteria, primarily informs academia at this early stage of the work, as it is broadening our understanding of what AMR itself is. Such work is a cornerstone of future research in this relatively underexplored area.
Sectors Agriculture, Food and Drink,Chemicals,Communities and Social Services/Policy,Environment,Healthcare,Government, Democracy and Justice,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

 
Description Our researchers are informing farmers and government agencies on how to treat farm slurry and bedding and the causes of AMR spread, and beginning to help the NHS reduce surgical infection with a newly developed toolkit. Findings have resulted in changes to the education of healthcare professionals, incorporation of our findings into NHS improvement projects and in informing governmental organisations such as the Animal and Plant Health Agency and DEFRA. Farmers have directly been informed by our novel research to understand more about the spread of AMR via direct farm visits and attendance at events such as National Sheep congress and the Sheep Breeders Round Table. Outreach activities have been significant, with between 1,000-5,000 estimated members of the general public interacted with on a personal level, including actively participating in research such as learning how to swab for antimicrobials in the local community. Our findings have been used to inform people interacting with us across the web, including social media presence and an exceedingly popular online course (for the general public and those working worldwide in farming-related sectors) via FutureLearn that was shortlisted for the Learning on Screen Awards 2017. Findings have been used to directly influence the economic prospects and technological advancement of local and multinational companies, including at meetings and events (activities have already impacted on competitive business decisions) and as a result of further direct work to develop a key piece of research (full economic outcomes yet to follow). Some elements of the impact cannot be shared due to business sensitivity and intellectual property concerns. Current impacts include economic, social, health and environmental and further impact is anticipated as pump prime projects achieve research and industrial funding as planned.
First Year Of Impact 2017
Sector Agriculture, Food and Drink,Education,Environment,Healthcare,Government, Democracy and Justice,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology
Impact Types Societal,Economic

 
Description Defra Antimicrobial Resistance Coordination group visit (5)
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact The findings from this research have been used to feed directly into government policy through being invited to DARC (DARC- government AMR advisory group) meetings to discuss the impact of cattle farming on environmental AMR. BH has published in the related area of AMU (goo.gl/NMvYMV), particularly focusing on the effect of antibiotic footbath effects on AMU, and has now commenced a PhD further researching this field, focusing on calf health to reduce AMU and AMR.
URL http://goo.gl/NMvYMV
 
Description Improving surgical site infection prevention practices
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact Part of the project has already been incorporated by the trust into the Chief Nurse Fellows improvement project programme and will be disseminated widely throughout the Trust. Changes made to teaching nursing best practice. No statistics as yet.
 
Description 'Modelling Antimicrobial Resistance', Wellcome Biomedical Vacation Scholarships (successful).
Amount £2,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2017 
End 09/2017
 
Description Agri-Tech Catalyst Innovate
Amount £112,180 (GBP)
Funding ID 132164 
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 03/2016 
End 10/2017
 
Description BBSRC Industrial iCASE PhD Studentship
Amount £75,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2017 
End 09/2020
 
Description Innovate UK grant
Amount £383,000 (GBP)
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 04/2018 
End 03/2020
 
Description Leverhulme Doctoral Scholarships MASS: Modelling and Analytics for a Sustainable Society
Amount £64,176 (GBP)
Organisation The Leverhulme Trust 
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 09/2020
 
Description MRC international application to attend the UK-China Newton AMR meet
Amount £3,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 11/2017 
End 11/2017
 
Description NIHR ICA Clinical Lectureship
Amount £641,493 (GBP)
Organisation NIHR/HEFCE Higher Education Fund for England 
Sector Academic/University
Country United Kingdom
Start 04/2019 
End 12/2022
 
Description Wellcome Trust DTP
Amount £4,200 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2017 
End 02/2018
 
Title Antimicrobial peptides HD9 - 3 
Description Small peptides developed in this project have shown potent microbicidal activity against MRSA, MSSA, Pseudomonas aeruginosa (PA) and Methicillin-resistant Staphylococcus epidermidis (MRSE). Patent to follow. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact Use in ongoing project, further details to remain undeclared prior to patent. 
 
Title Assessment of a polymer-based nanoparticulate system to enhance drug delivery of lactoferrin to prevent C. difficile infection 
Description Novel lactoferrin loaded alginate microgels have been fabricated using an emulsification/internal gelation method by Dr Shwana Braim, School of Pharmacy. 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact The proof of concept study aimed to apply existing methods to conjugate bovine lactoferrin with synthetic polymers to make it more stable and increase the amount of time it can circulate in the human body without being degraded. Different types of lactoferrin-polymer formulations are being tested and validated in batch cultures and the most appropriate formulation chosen for future testing. This will allow researchers to control and target the delivery of this therapeutic protein for the potential future treatment of C. difficile. We are now working beyond the original proof of concept with the Hannan Stem cell lab at CBS to evaluate antimicrobial, cytoprotective and the anti-inflammatory potential of novel lactoferrin microgels in 3D human intestinal organoids modelling C. difficile infection and Crohn's disease. 
URL http://www.nottingham.ac.uk/research/groups/bridging/impact/drug-delivery-to-prevent-c.-difficile.as...
 
Title Bacteriophages driving evolution towards loss of drug resistance 
Description Protocols for use of phage with AMR strains 
Type Of Material Model of mechanisms or symptoms - in vitro 
Provided To Others? No  
Impact Researchers are exploring the kinetics of plasmid loss from laboratory and field AMR E. coli and Salmonella strains and isolating and characterising specific bacteriophages for possible use. 
 
Title Desktop Viral Diagnostic 
Description Developed Gold-Aptamer Nano Constructs capable of detecting viral nucleic acid to high analytical and temporal sensitivity. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact Improved sensitivity of testing allowing for fast accurate testing for viral markers with non-invasive swab during a GP consultation using new imaging techniques - preliminary data used to support fellowship application (awaiting result) 
URL http://www.nottingham.ac.uk/research/groups/bridging/impact/desktop-viral-diagnostic.aspx
 
Title Development of Dual Anti- Adhesive/Antimicrobial Medical Devices 
Description Anti-attachment and antibiotic technologies successfully combined. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact In use within research team. Long term commercialisation may occur if the coating material research continues to progress well. 
 
Title Investigating Manufacture of Porous Glass Microspheres from Recycled Glass Waste Materials for Water Treatment (23) 
Description Methods have investigated synthesis of high melt temperature materials (i.e. silicates) for manufacture into porous microspheres, to remove micropollutants rom wastewater streams 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? No  
Impact Developments in business (confidential) 
 
Title Multi Layered and Blended Deposition of Sacrificial Thin-Film Coatings of Phosphate Based Glasses For Preventing Biofilm Formation 
Description Antimicrobial provisional thin coating of PBG utilising the potential of Ga3+ as an antimicrobial agent 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact In use by research team to deepen understanding of glass structures, biofilm formation and potential use in implants, 
 
Title New materials (6) 
Description New materials for oral drug delivery were developed in this project and these are being adapted for other EPSRC-funded projects, notably in the Next Generation Biomaterials Discovery EPSRC Programme Grant. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? Yes  
Impact Within the university used to explore new oral drug delivery methods 
 
Title Protein HD5 - 16 
Description The production of recombinant human defensin-5 (HD-5) protein (both in mature and precursor forms) for use in antimicrobial screening tests and as an analytical standard to allow quantification of endogenous material from patients suffering from inflammatory bowel diseases 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact Ongoing research use at University of Nottingham 
 
Title Super-porous microspheres for enhancing rapid immuno-diagnosis of bacterial infection 
Description Use of novel high surface area super-porous microspheres as part of a system to enhance the detection of early antibody responses to Pseudomonas aeruginosa. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact Developing a prototype lateral flow immunoassay (LFIA) POCT device as "proof of principle" using methods, this has not yet had impact on end users. 
 
Title Antibiotic and metal ion resistance genes in E. coli isolated from a wastewater treatment plant 
Description Collection of wastewater and stream water and exploration of resistant strains. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact To be used in further funding applications. 
 
Title Geospatial modelling 
Description Used GIS software to plot AMR data into a map of the Sutton Bonington area and include relevant geospatial layers. Statistical analysis on the spatial AMR data. 
Type Of Material Data analysis technique 
Year Produced 2016 
Provided To Others? No  
Impact None as yet (to be used to inform further research applications) 
 
Title Improving surgical site infection prevention practices to reduce antibiotic use and antimicrobial resistance 
Description Conducted exploratory interviews with 20 NHS staff to uncover issues which influence compliance with warming guidelines and attitudes towards surgical site infection prevention. Participants included all staff involved in the patient warming journey (e.g., surgical nurses, operating room staff, anaesthetists and surgeons). Data from the process map and interviews will be used to develop a whole systems patient warming implementation toolkit to prevent hypothermia and prevent SSI. 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? No  
Impact Beginning to impact on nurse training and NHS policy changes to follow. 
 
Title Mapping UK investments in antimicrobial resistance research in animals to advance the scientific understanding of AMR policy UG project 
Description The project utilized a hierarchical approach, efficient data mining methodologies including data acquisition, data extraction and mathematical data analysis. We established algorithms to identify trends and gaps and to reconstruct relationships between funded research and 'hotspots' geographical areas that seem to be more funded than others in the UK. This work leads to the establishment of the first dataset of funded research projects awarded to UK institutes from 1994-2016 relating to AMR research as well as all other research areas in veterinary medicine in the UK. 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact See also student placement entry. Collaborators in Surrey have worked with us to map major research funders with the intention of applying for further grant funds. 
 
Title Sheep DirtyGenes Totemeyer 
Description DirtyGenes software available as R code on FigShare associated with https://www.biorxiv.org/content/early/2017/10/16/204321 2018 Contributed to BBSCR Response mode application 'The role of livestock in the transmission of AMR between Environments' 
Type Of Material Data analysis technique 
Year Produced 2017 
Provided To Others? Yes  
Impact This method has broad uses for statistical testing and experimental design in experiments on changing microbiomes, including for studies on antimicrobial resistance. 
URL https://www.biorxiv.org/content/early/2017/10/16/204321
 
Title Should we worry about slurry 
Description New dataset with farm practices, heavy metal concentrations and AMR presence for 15 farms across GB. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? No  
Impact N/A at this stage - taking to conference this year 
 
Title Sleeping with the (AMR) enemy 
Description Tracking resistance levels in fresh slurry, and post process dry and liquid fractions. Examining the effect of storage of dry fraction, which will either have the potential to end up in the environment, or could be used on some farms as recycled manure solid bedding. Examining antibiotics/metals, and their levels, present within the manure. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact None as yet, further developments to follow. 
 
Title Summer studentship Antimicrobial resistance (AMR) and its environmental drivers: a pilot study in wildlife 
Description Testing of resistant strains within faeces from wild small mammals and birds across three sites, each around 0.5km apart. Site 1 was a small woodland neighbouring a dairy farm, site 2 was an arboretum and arable field edge, and site 3 a sewage treatment plant (STP) and its outflow. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact Papers and grant applications to be produced. 
 
Title The role of sheep in the transmission of AMR between farms and between environments 
Description Metagenomic data sets, identification of antimicrobial resistance genes in bacterial populations. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact N/A at this early stage in the research. 
 
Description AMR PVD surfaces 18 
Organisation Dexo Technologies Limited
PI Contribution Contribution of antimicrobial glass PVD techniques through proof of concept research.
Collaborator Contribution Contributed to Innovate application and discussions around commercialisation of product (still early stage)
Impact Innovate grant, proof of concept, papers to follow. Multidisciplinary - Engineering, Medicine, Advanced materials.
Start Year 2017
 
Description AMR PVD surfaces 18 
Organisation John Desmond Ltd
PI Contribution Contribution of antimicrobial glass PVD techniques through proof of concept research.
Collaborator Contribution Contributed to Innovate application and discussions around commercialisation of product (still early stage)
Impact Innovate grant, proof of concept, papers to follow. Multidisciplinary - Engineering, Medicine, Advanced materials.
Start Year 2017
 
Description AMR in the environment 
Organisation University of Groningen
Country Netherlands 
Sector Academic/University 
PI Contribution Visiting scholars (see events entries) and ongoing collaborations on projects such as "geospatial modelling the spread of AMR in the environment".
Collaborator Contribution Sharing of unpublished results, collaboration on Nottingham projects and joint grant applications being composed to external funders.
Impact Multidisciplinary - Mathematics, Biosciences, Vet Sci, Environmental microbiology.
Start Year 2016
 
Description AMR in the environment 
Organisation University of KwaZulu-Natal
Country South Africa 
Sector Academic/University 
PI Contribution Visiting scholars (see events entries) and ongoing collaborations on projects such as "geospatial modelling the spread of AMR in the environment".
Collaborator Contribution Sharing of unpublished results, collaboration on Nottingham projects and joint grant applications being composed to external funders.
Impact Multidisciplinary - Mathematics, Biosciences, Vet Sci, Environmental microbiology.
Start Year 2016
 
Description Assessment of a polymer-based nanoparticulate system to enhance drug delivery of lactoferrin to prevent C. difficile infection 
Organisation Jagiellonian University
Country Poland 
Sector Academic/University 
PI Contribution Partners at Jagiellonian University have helped produce iron and manganese saturated lactoferrin solutions for use in the project. As part of our microgel studies, we are also investigating the significance of biometal concentrations (iron, zinc, copper and magnesium) in sera from patients with C. difficile infection in an attempt to stratify patients with mild and severe infection. These studies are in collaboration with Prof Marcin Frankowski, Adam Mickiewicz, University of Poznan, Poland. We are working with investigators at Nottingham Trent University where we will under miRNA studies in the organoids pre and post exposure to C. difficile bacteria, purified toxins and the lactoferrin microgels. These studies are in collaboration with Dr Christos Polytarchou.
Collaborator Contribution See above
Impact See above. Multidisciplinary, Medicine, Pharmacy, Life Sciences and Chemistry
Start Year 2016
 
Description Assessment of a polymer-based nanoparticulate system to enhance drug delivery of lactoferrin to prevent C. difficile infection 
Organisation Nottingham Trent University
Country United Kingdom 
Sector Academic/University 
PI Contribution Partners at Jagiellonian University have helped produce iron and manganese saturated lactoferrin solutions for use in the project. As part of our microgel studies, we are also investigating the significance of biometal concentrations (iron, zinc, copper and magnesium) in sera from patients with C. difficile infection in an attempt to stratify patients with mild and severe infection. These studies are in collaboration with Prof Marcin Frankowski, Adam Mickiewicz, University of Poznan, Poland. We are working with investigators at Nottingham Trent University where we will under miRNA studies in the organoids pre and post exposure to C. difficile bacteria, purified toxins and the lactoferrin microgels. These studies are in collaboration with Dr Christos Polytarchou.
Collaborator Contribution See above
Impact See above. Multidisciplinary, Medicine, Pharmacy, Life Sciences and Chemistry
Start Year 2016
 
Description Assessment of a polymer-based nanoparticulate system to enhance drug delivery of lactoferrin to prevent C. difficile infection 
Organisation Poznan University of Medical Sciences
Country Poland 
Sector Academic/University 
PI Contribution Partners at Jagiellonian University have helped produce iron and manganese saturated lactoferrin solutions for use in the project. As part of our microgel studies, we are also investigating the significance of biometal concentrations (iron, zinc, copper and magnesium) in sera from patients with C. difficile infection in an attempt to stratify patients with mild and severe infection. These studies are in collaboration with Prof Marcin Frankowski, Adam Mickiewicz, University of Poznan, Poland. We are working with investigators at Nottingham Trent University where we will under miRNA studies in the organoids pre and post exposure to C. difficile bacteria, purified toxins and the lactoferrin microgels. These studies are in collaboration with Dr Christos Polytarchou.
Collaborator Contribution See above
Impact See above. Multidisciplinary, Medicine, Pharmacy, Life Sciences and Chemistry
Start Year 2016
 
Description Bacteriophages driving evolution towards loss of drug resistance 
Organisation Sao Paulo State University
Country Brazil 
Sector Academic/University 
PI Contribution Collaborative research and creation of manuscript under review
Collaborator Contribution Collaborative research and creation of manuscript under review
Impact Collaborative research and creation of manuscript under review
Start Year 2017
 
Description Desktop Viral Diagnostic 
Organisation Surescreen Diagnostics Limited
Country United Kingdom 
Sector Academic/University 
PI Contribution Established strong and strengthening links with two local SMEs TBG Solutions and Sure Screen Diagnostics in development of novel point-of-care diagnosis tool. Research team are contributing creation of highly sensitive Gold-Aptamer Nano Constructs, allowing for a step change in what is possible in a GP consultation.
Collaborator Contribution Industry are contributing expertise in engineering the product and the available market.
Impact Development of idea from concept to technology readiness level 4. Now looking for further funding to test in clinical settings and develop a working prototype. Multidisciplinary including Pharmacy, Life Sciences and Engineering.
Start Year 2016
 
Description Desktop Viral Diagnostic 
Organisation TBG Solutions
Country United Kingdom 
Sector Private 
PI Contribution Established strong and strengthening links with two local SMEs TBG Solutions and Sure Screen Diagnostics in development of novel point-of-care diagnosis tool. Research team are contributing creation of highly sensitive Gold-Aptamer Nano Constructs, allowing for a step change in what is possible in a GP consultation.
Collaborator Contribution Industry are contributing expertise in engineering the product and the available market.
Impact Development of idea from concept to technology readiness level 4. Now looking for further funding to test in clinical settings and develop a working prototype. Multidisciplinary including Pharmacy, Life Sciences and Engineering.
Start Year 2016
 
Description Innovate grant partners 19 
Organisation Intel Corporation
Department Intel Corporation (UK) Ltd
Country United Kingdom 
Sector Private 
PI Contribution Participation in Innovate UK grant
Collaborator Contribution Participation in Innovate UK grant
Impact Development of software - cross bioscience/informatics/vet medicine/industry.
Start Year 2016
 
Description Jagiellonian University Poland - ongoing research partnership (6) 
Organisation Jagiellonian University
Country Poland 
Sector Academic/University 
PI Contribution Ongoing research partnership and co-authors on a paper (see publications)
Collaborator Contribution Collaborative research
Impact Co-authors on a paper (see publications)
Start Year 2018
 
Description Mapping UK investments in antimicrobial resistance research in animals to advance the scientific understanding of AMR policy 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution Multidisciplinary supervisory team of experts in infectious diseases, algorithms designing, clustering analysis, and data mining to tackle the challenge of AMR from a completely new angle via mining databases of UK funders looking for trends and gaps in AMR research.
Collaborator Contribution As above.
Impact See placement and data set sections. Collaborators from Physics, Veterinary Medicine and Science and Medicine.
Start Year 2016
 
Description Mapping UK investments in antimicrobial resistance research in animals to advance the scientific understanding of AMR policy 
Organisation University of Surrey
Country United Kingdom 
Sector Academic/University 
PI Contribution Multidisciplinary supervisory team of experts in infectious diseases, algorithms designing, clustering analysis, and data mining to tackle the challenge of AMR from a completely new angle via mining databases of UK funders looking for trends and gaps in AMR research.
Collaborator Contribution As above.
Impact See placement and data set sections. Collaborators from Physics, Veterinary Medicine and Science and Medicine.
Start Year 2016
 
Description Severn Trent Water Undergraduate projects 
Organisation Severn Trent Water
Country United Kingdom 
Sector Private 
PI Contribution Researchers sourced undergraduate students willing and able to work on STW projects during summer 2016 and provided lab space and support.
Collaborator Contribution Contribution of research idea, consumables and student payment.
Impact See 'secondments section'. Multidisciplinary - engineering, vet science, biosciences.
Start Year 2016
 
Description Slurry and bedding projects feed in to EVAL Farms 
Organisation Animal and Plant Health Agency
Country United Kingdom 
Sector Public 
PI Contribution Expertise, data and research outcomes feed in to EVAL farms meetings
Collaborator Contribution Strategic questions, guidance and data access
Impact Change to policy - see Influence
Start Year 2016
 
Description Slurry and bedding projects feed in to EVAL Farms 
Organisation Food Standards Agency (FSA)
Country United Kingdom 
Sector Public 
PI Contribution Expertise, data and research outcomes feed in to EVAL farms meetings
Collaborator Contribution Strategic questions, guidance and data access
Impact Change to policy - see Influence
Start Year 2016
 
Description Slurry and bedding projects feed in to EVAL Farms 
Organisation James Hutton Institute
Country United Kingdom 
Sector Public 
PI Contribution Expertise, data and research outcomes feed in to EVAL farms meetings
Collaborator Contribution Strategic questions, guidance and data access
Impact Change to policy - see Influence
Start Year 2016
 
Description Slurry and bedding projects feed in to EVAL Farms 
Organisation Lindhurst Engineering Ltd
PI Contribution Expertise, data and research outcomes feed in to EVAL farms meetings
Collaborator Contribution Strategic questions, guidance and data access
Impact Change to policy - see Influence
Start Year 2016
 
Description Slurry and bedding projects feed in to EVAL Farms 
Organisation National Farmers Union
Country United Kingdom 
Sector Public 
PI Contribution Expertise, data and research outcomes feed in to EVAL farms meetings
Collaborator Contribution Strategic questions, guidance and data access
Impact Change to policy - see Influence
Start Year 2016
 
Description Slurry and bedding projects feed in to EVAL Farms 
Organisation Severn Trent Water
Country United Kingdom 
Sector Private 
PI Contribution Expertise, data and research outcomes feed in to EVAL farms meetings
Collaborator Contribution Strategic questions, guidance and data access
Impact Change to policy - see Influence
Start Year 2016
 
Description Slurry and bedding projects feed in to EVAL Farms 
Organisation The Veterinary Medicines Directorate
Country United Kingdom 
Sector Hospitals 
PI Contribution Expertise, data and research outcomes feed in to EVAL farms meetings
Collaborator Contribution Strategic questions, guidance and data access
Impact Change to policy - see Influence
Start Year 2016
 
Description Slurry and bedding projects feed in to EVAL Farms 
Organisation Velcourt Ltd
Department Velcourt R&D
Country United Kingdom 
Sector Private 
PI Contribution Expertise, data and research outcomes feed in to EVAL farms meetings
Collaborator Contribution Strategic questions, guidance and data access
Impact Change to policy - see Influence
Start Year 2016
 
Description Trent Simulation and Clinical Skills Centre - joint Masters programme in Quality and Patient Safety. 
Organisation Nottingham University Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution This new postgraduate programme has been co-designed by academic and clinical experts and aims to promote the application of scientific principles and theory in day to day practise. Creation and running of course for those planning or developing their career in the health and social care sector (public, private and voluntary) including clinical staff, professional managers and commissioners but is also suitable for those interested in education and teaching in this field and associated research, innovation and scholarship. Advertising course
Collaborator Contribution See above
Impact School of Health Sciences, University of Nottingham Centre for Health Innovation, Leadership and Learning (CHILL, Nottingham University Business School) Human Factors Research Group (HFRG), Faculty of Engineering, University of Nottingham Trent Simulation and Clinical Skills Centre, Nottingham University Hospitals NHS Trust
Start Year 2018
 
Title Bovine mastitis - 19 
Description Software diagnostic tool, that based on MALDI-TOF MS data, recognises the presence of specific S. aureus strains (penicillin resistant vs. non-resistant strains), and suggests the most appropriate treatment. 
Type Of Technology Software 
Year Produced 2017 
Impact Innovate UK grant funded 2018-2020 to use software. No impact as yet. 
 
Title Low cost protein spraying equipment 
Description Low-cost protein spraying equipment for lateral flow immunoassay production 
Type Of Technology Physical Model/Kit 
Year Produced 2017 
Impact Currently in use to explore use of porous microspheres in targeting antibiotics 
 
Title PDMS coating 17 
Description New method to coat PDMS loaded with antimicrobials in a manner in which the antimicrobials can still be delivered 
Type Of Technology New/Improved Technique/Technology 
Year Produced 2017 
Impact None as yet excepting use in pump prime. Commercial uses will be explored in 2018. 
 
Title Smart sensor for UTIs - 13 
Description A tabletop SPR instrument for monitoring of bacterial binding to treated surfaces and bacteriophage. 
Type Of Technology Systems, Materials & Instrumental Engineering 
Year Produced 2017 
Impact Research only use at present, used to monitor abx action and biofilm assembly in real time. 
 
Description AMR Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Third sector organisations
Results and Impact Aimed to bring together people from a variety of sectors working in AMR to inform about the research at the university, create new cross-disciplinary relationships and develop ways of working together for the interests of everyone involved. There were eight external speakers representing the NHS, The Global AMR Innovation Fund, Animal Health and Welfare Board for England, Public Health England, the University of Warwick, the University of Exeter, and the Food Standards Agency, and a Member of Parliament. Internal speakers included the Principal Investigator, the PVC for Research and Knowledge Exchange, an Emeritus Professor of Microbiology and 17 researchers representing their Bridging the Gaps pump prime funded work. There were also networking activities and flash presentations. 90% of attendees who completed the follow up survey noted that they had made new contacts as a result of the event, including essential links between researchers and representatives of groups such as AHWBE and PHE.
Year(s) Of Engagement Activity 2017
 
Description AMR Early Careers Network in Science and Technology Studies 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact The AMR Early Careers Network in Science and Technology Studies, which runs (non-BtG funded) workshops and events, was formed from Medicine and Sociology researchers meeting at a BtG event. Workshop event organised summer 2016 aimed at early career researchers.
Year(s) Of Engagement Activity 2016,2017
 
Description AMR club 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact AMR club is an informal lunch session organised roughly once a month. Aimed at mostly PhD and postdoc students, but open to all researchers, the group is an opportunity to share what people are currently working on, techniques that they are using, new developments in the field and suggest solutions to problems when appropriate. The club started out specifically aimed toward mathematical modellers but widened as interest grew. Informal feedback from the club has been positive, PhD students and postdoctoral researchers have expressed enjoyment at being able to form a community of early career researchers, especially as the area of AMR can be diverse and divided by distance. The group is a useful way to draw early career researchers in to participating in other events - for example the winning sandpit idea from the environment sandpit was an idea originally raised at AMR club and the PhD student was encouraged to attend the sandpit event.
Year(s) Of Engagement Activity 2016,2017
 
Description Antibiotic awareness week outreach 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Outreach activities organised as part of antibiotic awareness week with a variety of games and information provided at a stall at Sutton Bonington. Largely aimed at students in Biosciences and Vet Science and Medicine. Swab and send and design a cuddly microbe activities also advertised via twitter and other social media accounts. Future events are planned at primary schools, open days and public festivals. Audiences at the antibiotic awareness week were taught about importance of antimicrobial resistance, which is especially important to direct future scientists in to this area and to ensure that students who go on to roles as vets, food scientists, etc are aware of the importance and risks of AMR in their work.
Year(s) Of Engagement Activity 2016
 
Description Bridging the Gaps website and twitter 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Third sector organisations
Results and Impact Bridging the Gaps website and twitter created (in parallel with intranet site [workspace]). Site and twitter account were used to promote events, increase networking between researchers, connect with industry, promote funding calls and show impact. Bridging the Gaps saw an increase in the number of queries from other UK universities interested in networking with the University of Nottingham and received several approaches from industry from the site. The site also provided a clear explanation of Bridging the Gaps' work to industrial partners, allowed the general public/media to search for the programme, and enableed internal researchers to easily access funding information.
Year(s) Of Engagement Activity 2015,2016
URL http://www.nottingham.ac.uk/research/groups/bridging/index.aspx
 
Description Challenge day General Practitioner 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Approximately 15 researchers attended for presentations from Simon Royal (current practicing GP), Richard Puleston (consultant, Public Health England) and Richard Knox (clinical associate, internal) followed by discussion and brainstorming research proposals. The event was intended to result in closer connections between EPS researchers and clinicians and help to direct research towards this area e.g. POC tests. Feedback following the event was positive and one (unsuccessful) application was received for event-associated funding.
Year(s) Of Engagement Activity 2016
 
Description Challenge day Infection Control 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Seven researchers attended to discuss infection control with two speakers - Martin Kiernan (infection prevention society) and Natalie Vaughan (NHS) with the intention of directing research towards interventions bedded in the practicalities and necessities of the NHS. The event did not result in funding applications but the relationships with the speakers has proven ongoing and they are now being invited to support other related pump prime activities.
Year(s) Of Engagement Activity 2016
 
Description Challenge day Pig and Poultry Farming 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Presentations were given by Paul McMullin (Poultry Health Services), Lucy Coyne (AHDB Pork team) and Mike Clark (Minister Vets) to a group of researchers with the intention of educating and encouraging research focusing on the specific area of antimicrobial resistance in farming. This resulted in open discussion and creation of research proposals with novel cross-disciplinary teams. Two applications were submitted for pump prime event-associated funding, there was one winner of the <10k.
Year(s) Of Engagement Activity 2016
 
Description Challenge day Severn Trent Water 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Industry/Business
Results and Impact 25 researchers and five Severn Trent Water (STW) representatives attended the first Challenge day on 8th Jan. A presentation on the challenges in the water industry was given by STW, then the researchers intensively brain-stormed ideas and began to create research proposals to explore the challenges. The event resulted in new, novel, and cross-disciplinary research ideas and several researchers plan to submit applications for Bridging the Gaps pump prime funding awards to progress these ideas. STW reported many short and long term changes they might make as a direct result of the event and this progressed to a deeper relationship including reciprocal site visits and financial contributions to research in 2016-17.
Year(s) Of Engagement Activity 2016
 
Description Contributions to news articles 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interest from media organisations and articles published, resulting in greater interest from general public and researchers across AMR areas, not just funded researchers but all AMR at the institution: https://www.theguardian.com/commentisfree/2015/nov/20/antibiotics-apocalypse-research-resistance-threat-breakthrough, https://phys.org/news/2017-10-predatory-bacteria-portholes-frescoes.html, https://today.mims.com/the-antibiotic-consensus-accepting-and-responding-to-uncertainty-in-healthcare, https://bioengineer.org/novel-tool-for-vets-and-farmers-to-monitor-and-reduce-antibiotics-on/, https://today.mims.com/the-antibiotic-consensus-accepting-and-responding-to-uncertainty-in-healthcare, Richard James Sky news 23 Oct 2017 interview,
Year(s) Of Engagement Activity 2017
 
Description Desktop Viral Diagnostic - TBG Solutions and SureScreen Diagnostics meetings 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact This Bridging the Gaps funding has bought together two local SMEs, TBG Solutions and SureScreen Diagnostics, to develop diagnostic devices to for viral biomarkers in order to establish new approaches to solving to the global grand challenge of antimicrobial resistance.

The project partners have advanced their ideas from Technology Readiness Level 1, where the principles of the viral diagnostic have been observed and reported to Technology Readiness Level 4 where the diagnostic to viral nucleic acid has been validated in a laboratory environment. This progression has made the technology amenable to national funding in order to advance the project beyond the Bridging the Gaps funding by testing the diagnostic in clinical setting and the development of a working prototype.
Year(s) Of Engagement Activity 2016,2017
 
Description Digestive Diseases Week (DDW) Washington DC and press (6) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Co-authored article abstract selected for inclusion in the press program for this year's Digestive Diseases Week (DDW) Washington DC. The work has also featured in an article in the New York Times and New York Daily News:
https://mobile.nytimes.com/2018/06/05/well/live/fecal-transplant-stool-donor.html
https://www.eurekalert.org/pub_releases/2018-06/ddw-moa060418.php
http://www.nydailynews.com/life-style/ny-fea-poop-donations-altruism-20180604-story.html
Year(s) Of Engagement Activity 2018
URL https://mobile.nytimes.com/2018/06/05/well/live/fecal-transplant-stool-donor.html
 
Description External Company (project 22, cannot be detailed) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Engagement with company - Face to face meetings held plus additional phone calls held throughout 2018

Also engaged with Changing Markets charity (original contact made at BtG conference) regarding related policy and campaigning developments but no further progress at this stage
Year(s) Of Engagement Activity 2018
 
Description Industry networking meetings 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Nine industry networking events/meetings organised to share information about ongoing research and help to bridge gaps between industry need and current research at the institution. Included visits to industry in addition to hosting contacts at the university. Increased interest in industry approaches after these events, including industry providing funding for proof of concept projects and proposing new avenues for future work.
Year(s) Of Engagement Activity 2017
 
Description July 2017 STEM workshops 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact STEM workshops at schools - Charnwood College Loughborough, Limehurst Academy Loughborough, Woodbrook Vale Loughborough, John Ferneley College Melton Mowbray - - 'Hunt for new antibiotic producers' & interactive games => 40 swabs
Year(s) Of Engagement Activity 2017
 
Description June 2017 Wonder outreach 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact 'Wonder' - public event - information stalls & interactive games integrated into 'World of Dogs'. Project 6 on lactoferrin also represented at the same event and at open days.
Year(s) Of Engagement Activity 2017
 
Description Launch event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact The launch event occurred on the 17th November 2015 and was attended by around 100 individuals from 16 Schools across The University of Nottingham (UoN). Speakers included Nancy Mendoza (Society for Applied Microbiology), Professor Paul Williams (Centre for Biomolecular Sciences, UoN), Professor Liz Sockett (Medicine & Health Sciences, UoN) and Dr Dov Stekel (Biosciences, UoN). The event also included a networking event and two minute presentations given by attendees on their research areas.

Attendees reported an increase in their awareness of funding opportunities and an increased interest in collaborating on AMR research. Around 35 attendees registered for future updates from Bridging the Gaps.
Year(s) Of Engagement Activity 2015
 
Description Launch event press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact The Launch event for the project was advertised in a press release on The University of Nottingham's website. This promoted the event to internal audiences (evidenced by the increase in registered attendees) and more widely to any person searching for the University of Nottingham and antimicrobial resistance, or searching for the Bridging the Gaps programme.
Year(s) Of Engagement Activity 2015
URL http://blogs.nottingham.ac.uk/newsroom/2015/11/16/antimicrobial-resistance-the-search-for-new-collab...
 
Description Lord O'Neill lecture and panel discussion 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Event organised by the Graduate School, with panel members heavily involved in BtG. Audience of alumni, industry contacts and the general public. Increased interest in AMR at the university as a result of the lecture, including challenging panel questions and many new connections made between university researchers, the Discipline Bridging Officer, industry and policy makers.
Year(s) Of Engagement Activity 2016
 
Description Loughborough networking 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Third sector organisations
Results and Impact Meeting of nine researchers intended to look at potential collaborations between Nottingham and the University of Loughborough. The meeting mostly involved sharing of expertise but there have been no outcomes as yet.
Year(s) Of Engagement Activity 2016
 
Description MOOC on AMR in the Food Chain 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Bridging the Gaps contributed directly to the content of the MOOC by networking researchers and industrial contacts. Their research interests and questions were later integrated into the course materials, especially those research questions emerging from the Severn Trent Water Challenge day. The course was nominated for the Learning on Screen awards 2017.
Year(s) Of Engagement Activity 2017
URL https://www.futurelearn.com/courses/antimicrobial-resistance-food-chain
 
Description March 2017 School visit 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact School visit Sutton Bonington Primary school (3x 30 pupils, reception, Y1 & Y2) - 'Hunt for new antibiotic producers' & interactive games => 25 swabs
Offer Holder Day ( ~120 offer holders & parents) - information stalls, interactive games & quiz
Year(s) Of Engagement Activity 2016,2017
 
Description May 2017 Public festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact SB Fest - public event - 'Hunt for new antibiotic producers' information stalls, interactive games, quiz, perception of antibiotic use and AMR survey =>300 swabs handed out and 131 swabs returned
Year(s) Of Engagement Activity 2017
 
Description National Institute of Materials Physics (Romania) (18) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Dr Stuart visited National Institute of Materials Physics (Romania)
Year(s) Of Engagement Activity 2018
 
Description Networking events - Speed and STW 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact 32 researchers (excluding the Launch event) have so far attended networking events to meet colleagues from different disciplines. This includes a speed networking session 26th November 2015 and a networking event at the Severn Trent Water Challenge Day. Researchers have reported a greater awareness of research into AMR and an increase in the number of novel connections they have made.
Year(s) Of Engagement Activity 2015,2016
 
Description Nottingham in Parliament 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Visit organised as part of Nottingham in Parliament Day. Researchers visited two MPs and met also with Veterinary Medicines Directorate (VMD) representatives. Discussions resulted in changing views of MPs with actions being taken including asking the Secretary for Health to keep AMR a high priority and a possible invite to speak at an all-parliamentary working group, plus increased interest in visits to Nottingham. Conversations with VMD resulted in exchange of policy-relevant information and increased awareness of what the university may have to offer on the national level, e.g. possible use of parasitic bacteria in animal treatment in the very long term.
Year(s) Of Engagement Activity 2016
 
Description Nov 2016 AMR Awareness Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact SB campus: 'Hunt for new antibiotic producers' information stalls, interactive games, quiz, Competition: 'Design cuddly Veterinary Microbe'
Cardiff Sixth Form College - 'Hunt for new antibiotic producers'
=> 200 swabs handed out and 130 swabs returned, increased engagement observed via social media
Year(s) Of Engagement Activity 2016
 
Description Nov 2017 Abx Awareness Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Series of short lunchtime talks by academic staff involved in AMR research and a fun AMR 'Treasure Hunt', see urls https://www.vettimes.co.uk/news/superbug-fighting-microbes-revealed-at-amr-awareness-day/ http://www.nottingham.ac.uk/news/pressreleases/2017/november/students-reveal-superbug-fighting-microbes-at-amr-awareness-day.aspx plus identifying 18 potential new antimicrobial producers.
Year(s) Of Engagement Activity 2015,2016,2017
URL https://www.vettimes.co.uk/news/superbug-fighting-microbes-revealed-at-amr-awareness-day/
 
Description RMS bedding British cattle veterinary association annual congress 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Preliminary research presented at the British cattle veterinary association annual congress. Raised interest in the project amongst relevant professionals.
Year(s) Of Engagement Activity 2017
 
Description Roberto Rusconi seminar 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Seminar given to an audience of undergraduates, postgraduates, research fellows and other researchers, well received and new contacts created as a result. Unpublished data was also shared with researchers, allowing them access to cutting edge data and new research directions.
Year(s) Of Engagement Activity 2017
 
Description Sandpit event Environment 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact The event was intended to encourage specific pump prime activity around AMR in the environment and attracted a group of 20 attendees from a variety of mostly EPS areas. Many new networks were formed that included speakers Katherine Grace (DEFRA) and Jason Snape (AstraZeneca). Researchers enjoyed the format and were keen to attend future events; both oral and written feedback was positive. The event resulted in one £20k prize winner and two further projects presented here went on to successfully obtain pump prime funding during a later funding call.
Year(s) Of Engagement Activity 2016
 
Description Sandpit event NHS 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact On the first Sandpit (20-22nd Jan) 20 researchers were joined by representatives from NHS surgical infection and clinical microbiology staff and from a company which creates disposable curtains for the NHS. Researchers received presentations on current issues in AMR and then networked to form multi-disciplinary teams to create project proposals. On the final day researchers presented their proposals and all of those present at the event voted for the winning team to receive up to £20,000 in pump prime funding. The event created many novel interactions and new research ideas (as reported in researcher feedback) and increased connections between NHS staff and researchers, many of whom are planning future collaborations across institutional boundaries. Researchers expressed an interest in attending future events and in applying for further pump prime funding. The winning bid will be funded from mid-Feb.
Year(s) Of Engagement Activity 2016
 
Description Sandpit event data discovery 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact One day event joined by around 13 researchers plus Mat Diggle (Clinical Lead for Molecular Diagnostics for East Midlands Pathology) and Francesca Martelli (Animal and Plant Health Agency) for presentations, discussion and creation of novel proposals involving new cross-disciplinary teams. The event was followed by a short session the following week where attendees presented their proposal, a vote was taken and the highest rated proposal was successfully funded up to £20k. Researchers fed back that they had new contacts as a result of attending this event. Unsuccessful proposals from the event were rewritten and resubmitted at later funding calls.
Year(s) Of Engagement Activity 2016
 
Description Sept 2017 Usk Agricultural Show 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Usk Agricultural Show, Wales (9th September 2017), engaged with members of the public via interactive sessions
Year(s) Of Engagement Activity 2017
 
Description Sept Open days 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact SVMS/University of Nottingham Open Days (15th & 16th September 2017).
Year(s) Of Engagement Activity 2016,2017
 
Description Student expo 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact The UG project students presented their posters alongside other students at an event in Mathematical Sciences. Researchers attended from across the institution and the event was also open to members of the general public. The UG students had the opportunity to showcase their research to people not engaged in the same area of research.
Year(s) Of Engagement Activity 2016
 
Description Visitor Chirove Faraimunashe (University of KwaZulu-Natal) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Visit from three scholars (Bridging the Gaps funded only this one) with the intention of producing research plans for rapid response to future calls and disseminating information to, and making collaborative links with, seminar attendees. Seminars were organised as mini-symposia with 20 at the first and 12 at the second. Researchers began to formulate concrete proposals following on from this event and The University of Nottingham is also considering ways to engage with UKZN on an institutional level.
Year(s) Of Engagement Activity 2017
 
Description Visitor Joana Falcao-Salles 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other audiences
Results and Impact Part of the visiting scholar seminar series, this visitor works on some novel AMR research of relevance to Vet Sci, Maths, Biosciences, Pharmacy, Food sci, Engineering and Geography. The visit was intended to explore research opportunities and to disseminate information via two seminars at two different university campuses. Attendance was 20 per seminar. There was an increase in researchers engaging in collaborative work with one another and with the visitor following on from this event.
Year(s) Of Engagement Activity 2016
 
Description Workshops Drug discovery/novel materials 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact A one day event with two workshops, attendees were able to attend either one or both, with the majority staying for the full day. Around 15 researchers were joined by a visiting scholar from the University of Bradford and industry representatives. The workshops involved presentations, flash presentations from attendees and brainstorming sessions. One prize up to £10k was available to a novel cross-disciplinary proposal resulting from each event. One application was received and, though unsuccessful, the new collaboration created at this event did go on to secure funding in a later pump prime call. Relationships were built with pharmaceutical company RedX.
Year(s) Of Engagement Activity 2016