Novel Strategies to Detect and Mitigate the Emergence of AMR in Zoonotic Pathogens

Lead Research Organisation: University of Surrey
Department Name: ATI Electronics

Abstract

Antimicrobial resistance (AMR) is one of the most critical challenges facing science in the 21st century. For decades we have benefited from the widespread availability of drugs to treat a variety of conditions using antibiotics with penicillin becoming one of the most recognizable drugs in terms of public awareness. However, through the natural evolution of pathogens, accelerated by the over-use of antimicrobial drugs, the effectiveness of current treatments to such interventions is reducing. Indeed the emergence of pathogens which are fully resistant to antimicrobial drugs, though limited, is becoming an increasing trend. As a direct result of the serious implications and threats this poses the UK has established a 5-year AMR challenge to researchers, mirrored internationally, to address these issues.

In considering AMR it is important that the risk to human health from the emergence of AMR in livestock is also recognized and addressed. The use of antibiotics in this context is also widespread, and the emergence of AMR is occurring as seen in human pathogens. Given the food chain, and environmental factors such as waste treatment and run-off, there is significant risk that this may offer a pathway for the translation of AMR pathogens from animals into humans.

Much of the study into AMR and its emergence has naturally been undertaken by researchers within the life sciences. However, researchers within the engineering and physical sciences (EPS) have for many years contributed strongly to the development of life and medical sciences through the development of new characterization tools, advanced mathematical modelling techniques, and through the development of increasingly smart sensors to give a few examples. There is therefore significant scope for engaging EPS researchers directly with addressing the AMR challenges with the aim of accelerating the development of new techniques and tools for identifying and addressing the problem.

This project will create a space in which we will bring together researchers from the EPS community, including many leaders of their field, with those directly tackling AMR research challenges in the life sciences. We will do this through the creation of a Collaborative Hub for Advancing Interdisciplinary Research (CHAIR) at the University of Surrey. This CHAIR will be based in the newly established School of Veterinary Medicine, providing a neutral space to engage with researchers from across the EPS Departments within the University. To support and facilitate collaborations focused on addressing the AMR challenges we will run a series of integrated seminars, workshops and networking events which will lead to 'sandpits' at which researchers will work to propose short collaborative projects. Successful projects will then be eligible to apply to receive further funding with the aim of generating full research proposal submissions to funding bodies on the AMR challenges. We will also provide support in terms of research time to short projects, funds for short-term missions to support researcher interaction and information exchange, and network formation.

A series of researcher development and training activities will be offered in collaboration with the University's Researcher Development Programme. We will also closely engage with a number of strategic partners including the Defra Animal and Plant Health Agency, the Veterinary Medicines Directorate (VMD), The National Physical Laboratory (NPL), The Royal Surrey County Hospital, and internationally at North Carolina State University (USA) including supporting a short-term visiting appointment, and Universidad Sao Paulo (Brazil). This will significantly extend the potential impact of the activities we will support and provide new opportunities for wider collaboration.

Planned Impact

Who will benefit from the research?

The development of new collaborations between EPS and life science researchers to address AMR challenges will be of benefit across Government and society. The challenges faced are significant and of high importance, hence supporting new approaches to address them, if successful, will be a valuable contribution.

It is not often that an activity has this potential to deliver such broad-ranging impact that will be of benefit to a wide range of stakeholders and end users, outside of academia and industry, including funders of research and policy makers, government, healthcare institutions and those delivering it, education, the 'third sector' and the wider public, and the UK.

How will they benefit from this research?

Having initiated and been involved in defining the challenges we are addressing, funding bodies and stakeholders that they represent will benefit from the progress we make. The outcome of our research will inform and provide direct support for future research-programme prioritisation relating to these challenges. As new collaborations are developed, leading to new materials, technologies, and understanding applied to the issues surrounding AMR, other funders of research in different discipline areas will also benefit as the outcomes are translated into applications elsewhere. similarly, those developing future technologies and undertaking research and development in industry to address the AMR challenges will benefit from this project.

The UK will benefit from the creation of new cross-disciplinary collaborations and research undertaken, not only through the above contributions (and those described in the pathways to impact) to policy, industry, education etc., but by the consolidation of a leading competitive position in the development of next-generation technologies and approaches to address AMR. This will translate into the wider benefits of increased competitiveness in research and development, attracting further talent to the UK.

The outputs of the research proposed here will be of great benefit to policy makers such as Defra, FSA and EFSA. In addition it will be of great benefit to the scientific community. Commercial concerns will also benefit from the data generated as it may facilitate the development of novel antimicrobials and dosing regimes.

Much of the data generated from the project will be made publicly available. Furthermore, the PI and CI have strong links with other research groups, Defra, FSA, EFSA and commerce and thus will ensure information is appropriately communicated. We bring together leading experts and expect the medium to long-term impact will be felt beyond academics in the direct field of AMR, for example by:

Industry - Defining the mechanisms of AMR and the potential control strategies will be of interest to industry. Predictions & reagents arising from this work will be scrutinised for IP.

Policy makers - Improved strategies are required to control AMR in food-producing animals (pigs cattle and poultry in particular). A better understanding of AMR and its control will aid the effective targeting of resources & policy.

Food producers & consumers - By aiding the rational design of strategies to control AMR in food-producing animals this project will enhance animal welfare. Therefore, potential exists to improve economic & societal prosperity. Controlling AMR in animals will also reduce AMR transfer to humans and thus improving human health.

Publications

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Betts JW (2018) Novel Antibacterials: Alternatives to Traditional Antibiotics. in Advances in microbial physiology

 
Description Developed methodologies to bring different disciplines together, identify challenges that can be addressed by teams from different disciplines and establishing new collaborations. At the heart of the methodologies is the identification and articulation of discipline-specific challenge in a language understandable by the non-subject specific collaborator. Along side targeting specific challenges, creating an environment that brings together people to allow the development of serendipitous collaborations is often more rewarding and fruitful.
Exploitation Route The positive embracing of mechanisms and spaces in which people from different parts of an organisation can be brought together to develop collaborative work
Sectors Aerospace, Defence and Marine,Agriculture, Food and Drink,Chemicals,Communities and Social Services/Policy,Construction,Creative Economy,Digital/Communication/Information Technologies (including Software),Education,Electronics,Energy,Environment,Financial Services, and Management Consultancy,Healthcare,Leisure Activities, including Sports, Recreation and Tourism,Government, Democracy and Justice,Manufacturing, including Industrial Biotechology,Culture, Heritage, Museums and Collections,Pharmace

 
Description CHAIR Membership of Advisory Committees - Prof Roberto La Ragione
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
URL http://www.surrey.ac.uk/vet/people/academic/roberto_la_ragione/
 
Description Chair of the Humanimal Trust
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Chair of the Veterinary Pathology SAC for the RCPath
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description NHS AMR Diagnostics committee
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact The committee provides guidance on the most appropriate diagnostics for use in the NHS and for surveillance.
 
Description Participation in FSA ACSMF AMR committee
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Royal College of Nursing - Pets for Therapy
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description H2020 EJP CO-FUND
Amount € 91,000,000 (EUR)
Funding ID NA 
Organisation European Commission H2020 
Sector Public
Country Belgium
Start 01/2018 
End 12/2022
 
Description CHAIR Collaboration with International Researcher 
Organisation North Carolina State University
Country United States 
Sector Academic/University 
PI Contribution We will engage with the researcher for 50% of his time in EPS research centres (the ATI).
Collaborator Contribution He will undertake a one month visit this year and will be tasked with challenging and enthusing researchers to explore how they can engage in the AMR challenge and on increasing awareness of these. This will add an external voice to the project.
Impact This collaboration is multi disciplinary. The disciplines comprise engineering and physical sciences and veterinary medicine.
Start Year 2015
 
Description CHAIR University Global Partnership Network Proposal: Addressing the Antimicrobial Resistance Challenge Through Interdisciplinary Research 
Organisation North Carolina State University
Department Comparative Medicine Institute
Country United States 
Sector Academic/University 
PI Contribution CHAIR, in conjunction with NCSU has put together a proposal to the UGPN Research Collaboration Fund - Fifth Call for Proposals for an international symposium to bring together experts from NCSU and University of Surrey who are working in the area of antimicrobial resistance, and also the wider international community. The proposed symposium is to be held at NCSU and is planned to lead to strong research collaborations helping to address the problem of AMR.
Collaborator Contribution NCSU is to provide $12,000 for the symposium (if the proposal is successful) to cover the venue hire, symposium dinner, external speakers and subsistence and has been engaged in formulating the proposal with CHAIR. At NCSU there is the Emerging Infections Diseases research programme lead by Dr Sid Thakur in which AMR is an important topic and within this programme there is a working group lead by Dr Pierce that is focused on Drug Discovery for Infectious Pathogens. Both Dr Thakur and Dr Pierce are engaged with the proposal as Principal Investigators.
Impact This collaboration is multi disciplinary. Disciplines includes Veterinary Medicine, Microbiology, Chemistry, Electrical Engineering, Chemical Biology, Epidemiology.
Start Year 2016
 
Description Grant application - Understanding antimicrobial resistance : MR/N014359/1 
Organisation University of Surrey
Department Department of Microbial and Cellular Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Objectives of grant application : from my research team (a) To develop scanning probe nanoneedle technology to measure electrophysiology of individual live cells of E. coli. during normal growth and antibiotic exposure; (b) To measure electrophysiology of individual E. coli. persister cells during normal growth and during exposure to antibiotic;
Collaborator Contribution Planned contribution by partners: To use this information to gain insight into mechanisms of antibiotic killing and inspire new approaches to antibiotic development. Achieving these will provide a breakthrough in the understanding of antibiotic killing and provide a new novel methodology for its study. This highly innovative approach will provide the evidence required to establish a globally leading activity that will impact antimicrobial resistance research.
Impact Grant application MR/N014359/1 (Not funded). A funding mechanism to enable this project to commence is still being sought.
Start Year 2015
 
Description Grant application: Manufacturing with Light 2: Photocleavable Antibody Drug Conjugates (pADCs) EP/N018192/1 
Organisation University College London
Department Department of Chemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Our principal aim was to significantly extend our recent findings in the development of selectively photoactivated molecules for use in highly targeted cancer treatments in animals and humans. Specifically, we aim to enable a new class of more efficient photo-triggered drug delivery systems to be developed. Our novel approach to achieving this marks a clear departure from alternatives, and is based on the use of light as a 'green' reagent. Our previous demonstration of efficient photouncaging using visible and lower energy near-infrared light, thus avoiding the need for ultraviolet photons, was a key enabling step that justifies the full study now proposed. In this work we will explore the limits of what may be achieved using photocleavable Antibody Drug Conjugates (pADCs) to advance beyond current research horizons, where existing approaches have failed.
Collaborator Contribution This project will secure the highly successful collaboration formed between academic groups at Surrey and UCL, and expand them to establish a multidisciplinary research team of unique composition to achieve our aim. It will initiate a new research area in the field of the antibody drug conjugates (ADCs), providing significant advances towards the delivery of new cancer treatments and towards personalized medicine. A funding mechanism is still being sought to enable this to commence as planned.
Impact Grant application to EPSRC : EP/N018192/1 (Not funded). Multi-disciplinary project, electronics, organic chemistry and chemical biology, veterinary medicine.
Start Year 2015
 
Description Grant application: Manufacturing with Light 2: Photocleavable Antibody Drug Conjugates (pADCs) EP/N018192/1 
Organisation University of Zambia
Department School of Veterinary Medicine, University of Zambia
Country Zambia 
Sector Academic/University 
PI Contribution Our principal aim was to significantly extend our recent findings in the development of selectively photoactivated molecules for use in highly targeted cancer treatments in animals and humans. Specifically, we aim to enable a new class of more efficient photo-triggered drug delivery systems to be developed. Our novel approach to achieving this marks a clear departure from alternatives, and is based on the use of light as a 'green' reagent. Our previous demonstration of efficient photouncaging using visible and lower energy near-infrared light, thus avoiding the need for ultraviolet photons, was a key enabling step that justifies the full study now proposed. In this work we will explore the limits of what may be achieved using photocleavable Antibody Drug Conjugates (pADCs) to advance beyond current research horizons, where existing approaches have failed.
Collaborator Contribution This project will secure the highly successful collaboration formed between academic groups at Surrey and UCL, and expand them to establish a multidisciplinary research team of unique composition to achieve our aim. It will initiate a new research area in the field of the antibody drug conjugates (ADCs), providing significant advances towards the delivery of new cancer treatments and towards personalized medicine. A funding mechanism is still being sought to enable this to commence as planned.
Impact Grant application to EPSRC : EP/N018192/1 (Not funded). Multi-disciplinary project, electronics, organic chemistry and chemical biology, veterinary medicine.
Start Year 2015
 
Description NPL AMR 
Organisation National Physical Laboratory
Country United Kingdom 
Sector Academic/University 
PI Contribution Access to research programmes
Collaborator Contribution Steering committee membership and technical input.
Impact CHAIR Seminar.
Start Year 2015
 
Description RSCounty H AMR 
Organisation The Royal Surrey County Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Access to research programmes
Collaborator Contribution Steering group membership.
Impact Still active
Start Year 2015
 
Description Sao Paulo AMR 
Organisation University of Sao Paulo
Country Brazil 
Sector Academic/University 
PI Contribution Access to research programes
Collaborator Contribution Steering group membership.
Impact Attendance at UGPN event.
Start Year 2015
 
Description UGPN Partnership and Visit 
Organisation North Carolina State University
Country United States 
Sector Academic/University 
PI Contribution A visit was made to the University of Wollongong by Richard Curry with colleagues from the University of Surrey as part of the University Global Partnership Network which Wollongong has recently joined. Antimicrobial resistance issues were discussed with global partners.
Collaborator Contribution There are plans for future collaborative initiatives.
Impact The collaboration is multi-disciplinary.
Start Year 2015
 
Description UGPN Partnership and Visit 
Organisation University of Sao Paulo
Country Brazil 
Sector Academic/University 
PI Contribution A visit was made to the University of Wollongong by Richard Curry with colleagues from the University of Surrey as part of the University Global Partnership Network which Wollongong has recently joined. Antimicrobial resistance issues were discussed with global partners.
Collaborator Contribution There are plans for future collaborative initiatives.
Impact The collaboration is multi-disciplinary.
Start Year 2015
 
Description UGPN Partnership and Visit 
Organisation University of Wollongong
Country Australia 
Sector Academic/University 
PI Contribution A visit was made to the University of Wollongong by Richard Curry with colleagues from the University of Surrey as part of the University Global Partnership Network which Wollongong has recently joined. Antimicrobial resistance issues were discussed with global partners.
Collaborator Contribution There are plans for future collaborative initiatives.
Impact The collaboration is multi-disciplinary.
Start Year 2015
 
Description VetMed AMR 
Organisation The Veterinary Medicines Directorate
Country United Kingdom 
Sector Hospitals 
PI Contribution Access to research programmes
Collaborator Contribution Steering committee membership.
Impact Influencing research priorities.
Start Year 2015
 
Description AMR MOOC 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact AMR MOOC for Vets
Year(s) Of Engagement Activity 2020
 
Description AVS - Jan 2019 - AMR and biofilms - RVC -UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact A talk on AMR for the Association of Veterinary Students.
Year(s) Of Engagement Activity 2019
 
Description Bridging the Gaps National Symposium 14-15th June 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact A National Symposium for EPSRC funded Bridging the Gaps Network took place on 14-15th June at the University of Warwick and was organised and funded by INTEGRATE AMR (Warwick) and CHAIR (Surrey). It was attended by over 100 delegates from the eleven Bridging the Gaps Networks. Wednesday evening was an outreach event attended by the general public, raising awareness of AMR, and was followed by a dinner with speakers Sarah Kenney of Surgeon X (a comic funded by a Wellcome Trust arts grant) and Paul Cooke who has produced a film called 'CATCH' set in the near future when all antibiotics have stopped working. The following day there were talks from some external speakers, Dr Richard Seabrook of Medicines Discovery Catapult, Bruce Savage of GCF Diagnostics, Dr Elizabeth Beech of NIHR, Dr Abid Hussain of PHE and Dr Esther Robinson of PHE. There were then 18 short talks by Bridging the Gap network members, mainly on pilot projects funded by the networks, but also several overview talks on each network. Thirty posters were also presented during the breaks. It was a very interesting and successful event which was well attended.
Year(s) Of Engagement Activity 2017
URL https://www.surrey.ac.uk/feps/research/themes/health/CHAIR/events/bridging_the_gaps_national_symposi...
 
Description CHAIR Seminar 5: Antimicrobial resistance in bacteria: the problem with TB: 11/03/2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact The two speakers at the seminar were Prof Johnjoe McFadden, a co-investigator on the CHAIR project http://www.surrey.ac.uk/microbial/People/john_joe_mcfadden/index.htm and Dr Dany Beste both from the Department of Microbial Sciences at the University of Surrey. The seminar was followed by networking with attendees who included academic staff from the Vet School, Electronic Engineering, Chemistry and Maths.
Year(s) Of Engagement Activity 2016
URL http://www.surrey.ac.uk/feps/research/themes/health/CHAIR/events/amr.htm
 
Description CHAIR (Collaborative Hub for Advancing Interdisciplinary Research Seminar 3- 22/01/2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact A seminar took place which was open to staff and postgraduate students at University of Surrey on 'E-health: from sending, the IoT to big data - digital innovation in animal health'. Speakers were Dr Maxim Shkunov on sensing and Prof Alex Cook on 'Digital Innovation in Animal Health'.
Attendees were from all Faculties and it was held in the Business School. Attendees engaged in discussion following the talks on what the needs were of research into AMR on the biological side and what could be offered on the physical science side. Prof Alex Cook provided examples of how big data was assisting in the animal health world.
Year(s) Of Engagement Activity 2016
URL http://www.surrey.ac.uk/feps/research/themes/health/CHAIR/events/ehealth_from_sensing_the_iot_to_big...
 
Description CHAIR (Collaborative Hub for Advancing Interdisciplinary Research) Launch 4/11/2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact The launch took place in the new Vet School at University of Surrey. Prof Richard Curry (PI) introduced CHAIR whose aim is the create and support networks of researchers who together will develop a strong collaborative community, focussing on developing novel strategies to detect and mitigate the emergence of antimicrobial resistance (AMR) in zoonotic pathogens. Professor Roberto La Ragione spoke on AMR and explained the problems and its importance to the audience who were mainly from Faculty of Engineering and Physical Sciences. Dr Sid Thakur of University of North Carolina (a strategic partner for CHAIR) talked about his work via Skype link. The launch was also attended by Prof Peter Borriello, Head of Veterinary Services Directorate and Sarah Martin of Royal Surrey County Hospital NHS Trust (both institutions are also strategic partners for CHAIR). A discussion followed and also a networking session during which mathematicians and engineers expressed interest in getting involved in the project. There were 32 attendees at the launch in total.

It was agreed that Prof Richard Curry and Prof Roberto La Ragione would visit Prof Peter Borriello at the Veterinary Medicines Directorate for further discussion and collaboration and academic staff were added to a mailing list of those interested in the CHAIR project to be informed of future events.
Year(s) Of Engagement Activity 2015
 
Description CHAIR (Collaborative Hub for Advancing Interdisciplinary Research) Seminar 2 - 10/12/2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact The second CHAIR Seminar took place on 10th December 2015 and was attended by 32 academic staff. Ian Gilmore of NPL spoke on '3D metabolic imaging - the challenge going from tissue scale to single bacteria'. This was followed by short five minute presentations by other staff on their current research including Prof Ravi Silva and Dr Melanie Bailey.

There was useful discussion on how current research might contribute to developing novel strategies to detect and mitigate the emergence of AMR.
Year(s) Of Engagement Activity 2015
URL http://www.surrey.ac.uk/feps/research/themes/health/CHAIR/events/index.htm
 
Description CHAIR (Collaborative Hub for Advancing Interdisciplinary Research) Seminar 4 : Big data and modelling in healthcare 23/02/2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact For our fourth seminar, we attracted an audience of over 40 attendees from a range of Surrey University departments, Computer Science, Bioscience and Medicine, Vet School, Health Science, Maths, Chemical and Process Engineering and Psychology. There was also an attendee from NPL. Four speakers contributed, three from Computer Science and one from the Department of Clinical and Experimental Medicine who is also a GP. Networking took place afterwards and staff expressed an interest in further involvement in CHAIR and attendance at the Sandpit event planned for April.
Year(s) Of Engagement Activity 2016
URL http://www.surrey.ac.uk/feps/research/themes/health/CHAIR/events/big_data_and_modelling_in_healthcar...
 
Description CHAIR (Collaborative Hub for Advancing Interdisciplinary Research)Seminar 1 - 13/11/2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact The CHAIR Seminar consisted of an introduction to CHAIR by Professor Richard Curry, a talk on 'Rapid diagnostics for viral infections' by Dr Mark Atkins and a talk on 'Rapid diagnostics for bacterial infections' by Professor Roberto La Ragione. The Seminar was part of the Comparative Pathology Clinical Academic Group Launch Day and as such gave an opportunity to reach attendees from Surrey Health Partnership, Royal Surrey County Hospital NHS Trust, Ashford & St. Peter's NHS Hospitals Foundation Trust, Surrey Pathology Services and the Pirbright Institute.

Networking took place after the seminar and interest was expressed in further involvement in CHAIR by several academic staff.
Year(s) Of Engagement Activity 2015
URL http://www.surrey.ac.uk/feps/research/themes/health/CHAIR/events/index.htm
 
Description CHAIR Celebration Event Wednesday 13th September 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact The CHAIR Celebration event consisted of an afternoon event, where the CHAIR funded projects gave short presentations on the pilot projects to an audience of between 20-30, followed by a talk on IAA by Peter Lancaster and a presentation on the university's Innovation for Health research theme presented by Prof Helen Griffiths, Dean of the Faculty of Health and Medical Science.

A poster session with networking followed, which was open to staff, students and alumni. This was followed by a talk by Lord O'Neill on 'The economics of antimicrobial resistance and solving the threat'. Lord O'Neill is a Surrey alumnus and conducted the government review into AMR in 2016 and is an ex Treasury minister and well known economist. Sixty people signed up for the evening event. The talk threw a different light on the subject of AMR for those working on the scientific and biological side, giving the view from the point of view of economics.
Year(s) Of Engagement Activity 2017
URL https://www.surrey.ac.uk/feps/research/themes/health/CHAIR/events/
 
Description CHAIR Easter School 25th April 2017: Bridging the Communication Gap: Interdisciplinary Conversations 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact The CHAIR Easter School 'Bridging the Communication Gap: Interdisciplinary Conversations' was planned because of feedback from CHAIR funded projects which flagged up language and communication as challenges of working in an interdisciplinary environment. The Easter School was intended to bring together those working in bioscience, health science and medicine with others working in the physical sciences. There were twenty four participants including speakers. The morning session was run by the Research Development Programme and Lego ('Serious Play') was used as a tool for the participants to explain their research to others in small groups. Later in the session, those from the small groups explained another's research (from a different discipline) to the large group, again using models made from Lego. This was found to be both fun and enlightening.

Words / terms used which were not readily understood by non specialists or used with a different meaning in other disciplines were noted for future explanation or a glossary.

After lunchtime networking there were talks given by speakers who had worked in interdisciplinary projects. These included Prof Klaus Moessner of 5G working on the V-Hive project, Dr Maxim Shkunov working on the CHAIR sensors project, and Prof Roland Clift who set up the Centre for Environmental Studies at the University of Surrey. There was also a talk from Prof Matt Leach on the Surrey research theme of Urban Living and Sustainability, an introduction to 'Bright Club' by Katy Kennedy and a brief explanation of the Impact Acceleration Account by Peter Lancaster. Following the talks there was a general discussion and some more tailored queries on specific processes and possible other applications.
Year(s) Of Engagement Activity 2017
URL http://www.surrey.ac.uk/feps/research/themes/health/CHAIR/events/
 
Description CHAIR Outreach Session for Young People's University (sixth formers in residence at Surrey University for one week) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Fifty five sixth form students attending the Surrey Young Person's University week long session attended this session on Antimicrobial Resistance. Half were students hoping to study Biomedical Science and half were hoping to study Engineering. After an introduction to AMR by Dr Konstanze Hild a role play exercise took place involving all the participants, which was a command centre for a pandemic led by Dr Mike Hornsey of Surrey Vet School. This was to bring real life relevance to the challenge of AMR. It was a successful and thought provoking session. Students were divided into groups on tables labelled triage, logistics, media, executive committee and information was fed through from one group to another.
Year(s) Of Engagement Activity 2016
 
Description CHAIR Research Funding Sandpit 2 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Twenty eight academic staff (professors, post doctoral research assistants, lecturers) plus an attendee from NPL attended the Sandpit. Some proposals had been prepared in advance but attendees were invited to put forward an outline of an idea/proposal in three forty five minute slots, all aimed at working towards the challenge of AMR. Attendees were from the Surrey Vet School, Computer Science, ATI, Physics, Chemistry, Psychology, Mechanical Engineering, Chemical and Process Engineering and Environmental Engineering. At the end of the afternoon, eight proposals were put forward plus one which had already been sent in. New contacts were made and potential collaborations put forward. The proposals are to be refined and submitted to CHAIR decisions on funding.
Year(s) Of Engagement Activity 2016
URL http://www.surrey.ac.uk/feps/research/themes/health/CHAIR/events/index.htm
 
Description CHAIR Seminar 10: Dr Arnoud van Vliet, 'Biofilms, DNA and microbial pathogens: a market place for exchange of antimicrobial resistance?' and two CHAIR project reports 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact CHAIR organised a seminar focussing on Biofilms. The primary speaker was Dr Arnoud van Vliet from the University of Surrey Vet School speaking on 'Biofilms, DNA and microbial pathogens: a market place for exchange of antimicrobial resistance?'
There were also reports from two CHAIR funded projects:
Dr Peter Roth: 'Antifouling coatings to Prevent Biofilm Formation'
Dr Suzie Hingley-Wilson: 'Surface Printing to Investigate Drug Effects on Real Surfaces'.
This was followed by a lunch with networking for approximately one hour. Twenty eight staff and postgraduate students attended the seminar plus one attendee from NPL. Attendees included those from Civil and Environmental Engineering, Mechanical Engineering, Bioscience & Medicine, Chemistry, Vet School and Physics. New contacts were made.
Year(s) Of Engagement Activity 2017
URL http://www.surrey.ac.uk/feps/research/themes/health/CHAIR/events/chair_seminar_10.htm
 
Description CHAIR Seminar 11: Modelling and Big Data 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact The seminar took place in Maths Department and was attended by 32 academic staff and postgraduate students.
Two CHAIR funded projects reported on their research. These were 'AMR Data in Time and Space' by Ingrid den Uijl and 'Modelling in Mycobacterial Persistence, Dr Lillian Tang's project, reported on by Daniel Mansfield. The attendees were from a wide range of departments, Vet School, Chemical and Process Engineering, Music, Microbiology, Physics, Computer Science and Maths. The talks generated discussion and questions and was followed by lunch and networking.
Year(s) Of Engagement Activity 2017
URL https://www.surrey.ac.uk/feps/research/themes/health/CHAIR/events/chair_seminar_11_thursday_11th_may...
 
Description CHAIR Seminar 12: Two CHAIR funded projects: Sensors and Pharmacokinetics, Thursday 8th June 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact The 12th CHAIR seminar took place in the ATI on 8th June 2017 and the two speakers described the pilot projects funded by CHAIR, Sensors and Pharmacokinetics.

Dr Ruth Rawcliffe presented on the project led by Dr Maxim Shkunov, 'Towards Selective Detection of AMR Bacteria with a Disposable Electrical Sensor'.

Dr Tao Chen presented on 'Understanding the pharmacokinetics of antibiotic implants for veterinary applications'.

Twenty eight staff and post graduate students attended the seminar from a variety of backgrounds, Vet School, Chemical & Process Engineering, Chemistry, Physics, Electrical and Electronic Engineering, CES, Microbiology and Bioscience. There was networking before and after the seminar which was accompanied by lunch and some new contacts were made.
Year(s) Of Engagement Activity 2017
URL https://www.surrey.ac.uk/feps/research/themes/health/CHAIR/events/chair_seminar_12_thursday_8th_june...
 
Description CHAIR Seminar 6 - Tackling antimicrobial resistance: human and animal behaviour: 6/06/2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other audiences
Results and Impact The seminar was interdisciplinary in that the speakers were from the Vet School at the University of Surrey and the Department of Psychology. There were also four representatives from APHA, the Animal and Plant Health Agency, and attendees from Maths, Electronic Engineering, Mechanical Engineering, Environmental Strategy and Microbiology. The event is to lead to a proposal to Theme 4: Behaviour within and beyond the health care setting' which is part of the UK's cross council AMR funding initiative.
Year(s) Of Engagement Activity 2016
URL http://www.surrey.ac.uk/feps/research/themes/health/CHAIR/events/chair_seminar_6th_june.htm
 
Description CHAIR Seminar 7 Talk by Dr Sid Thakur of NCSU, Visiting Researcher plus reports from two CHAIR funded projects 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Dr Sid Thakur gave a presentation on 'A systems-based "One Health" approach to understand the complex dynamics of antimicrobial resistance (AMR) challenges.' Dr Thakur is an Associate Professor in the College of Veterinary Medicine at North Carolina State University. His research at NC State focuses on the molecular epidemiology of multi-drug resistant bacterial Salmonella and Campylobacter in the realms of pre-harvest food safety. Dr Thakur is Visiting Researcher at Surrey for the duration of July 2016. There were also two reports on CHAIR projects:
Dr Daniel Horton: Towards low cost very rapid diagnostics
Dr Charles Opoku: Towards selective detection of AMR bacteria with a disposable electrical sensor (CHAIR funded project)
The talks all provoked questions and discussion, in particular from the interdisciplinary point of view, towards an understanding of other disciplines.
Year(s) Of Engagement Activity 2016
URL http://www.surrey.ac.uk/feps/research/themes/health/CHAIR/events/chair_seminar_monday_11th_july.htm
 
Description CHAIR Seminar 8: Repurposing glucose monitoring technology for detecting DNA of infections organisms: 18/07/2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Kirill Alexandrov of Molecular Warehouse presented a seminar on 'Repurposing glucose monitoring technology for detecting DNA of infectious organisms'. Molecular Warehouse has received a grant from the Bill and Melinda Gates Foundation. http://molecularwarehouse.com/ Twenty six members of University of Surrey staff attended the seminar. There was also a presentation by Dr Niki Bardi on 'Antifouling Coatings to Prevent Biofilm Formation'. This is one of the CHAIR funded projects led by Dr Peter Roth. The talks were followed by networking.
Year(s) Of Engagement Activity 2016
 
Description CHAIR Seminar: Tuesday 18th July 2017: Dr Sid Thakur of NCSU 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Dr Sid Thakur, of North Carolina State University, academic visitor to University of Surrey, gave a talk on 'New and emerging threats of AMR from a global perspective'. Twenty six staff and PhD students attended the talk, which was followed by networking.
Dr Thakur's research at NC State focuses on the molecular epidemiology of multi-drug resistant bacterial salmonella and campylobacter in the realms of pre-harvest food safety.
Year(s) Of Engagement Activity 2017
URL https://www.surrey.ac.uk/feps/research/themes/health/CHAIR/events/chair_seminar_13_tuesday_18th_july...
 
Description CHAIR Stand for European Antibiotic Awareness Day Friday 18th November 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact On European Antibiotic Awareness day CHAIR had a stand in the Library building ground floor area, a main thoroughfare for students.

We distributed leaflets and talked to students who visited the stand about the challenge of AMR and the EPSRC funded research that CHAIR is involved with at Surrey. We used materials from Antibiotic Action, questionnaires to see how knowledgeable people were and offered them an opportunity to take part in the 'Superbugs' computer game. We also advertised our next event, the talk by Victoria Wells of Antibiotic Action on 1st December.
Year(s) Of Engagement Activity 2016
URL http://www.surrey.ac.uk/feps/research/themes/health/CHAIR/events/visit_chair_stand_for_european_anti...
 
Description CHAIR Website 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact A website was created for CHAIR the Collaborative Hub for Advancing Interdisciplinary Research to enable communication of events, news and funding opportunities to interested parties within and outside the University of Surrey.
As at 9th March 2016, 486 external hits and 2252 internal hits had taken place.
Year(s) Of Engagement Activity 2015,2016
URL http://www.surrey.ac.uk/feps/research/themes/health/CHAIR/index.htm
 
Description CHAIR participation in Innovation for Health opening 22nd February 2017 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact University of Surrey's new Innovation for Health building was formally opened on 22nd February by Sir Mark Walport, Chief Scientific Adviser to the UK Government There were approximately 140 attendees from a range of academic, local, business and educational backgrounds. The world-class facility is designed to enable students from engineering, biomedical and health sciences to learn alongside each other, giving valuable insight into each other's speciality and engaging in hybrid research driven projects. CHAIR had a stand at the opening which was visited by many of the attendees. As well as giving an overview of CHAIR's aims and projects, we also had two members of CHAIR projects on the stand who were able to explain aspects of their work in more detail as well as demonstrating a Genie instrument and an example of a microfluidic device to demonstrate novel assays using current technology. it was a worthwhile afternoon.
Year(s) Of Engagement Activity 2017
URL http://www.surrey.ac.uk/feps/research/themes/health/CHAIR/news/
 
Description Conference Attendance - NAMRIP Launch 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Dr Konstanze Hild, CHAIR Facilitator and Mrs Angela Day, CHAIR Administrator, attended the NAMRIP Launch Conference and Exhibition at the University of Southampton on Monday 14th December 2015. NAMRIP received £870,000 from EPSRC Network for Antimicrobial Action 'Bridging the Gap' call so is a parallel project to CHAIR. The conference was very informative and included keynote speakers Professor Dane Sally Davies and Professor Guy Poppy.

Dr Hild and Mrs Day made useful contacts with Southampton staff on the day which will be useful in the future.
Year(s) Of Engagement Activity 2015
URL http://www.southampton.ac.uk/namrip/news/events/2015/12/launch-conference.page
 
Description EMBRACE Conference 2016 in Antimicrobial Resistance 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Dr Konstanze Hild, Facilitator for CHAIR and Dr Nan Ma, post doctoral researcher for CHAIR attended a conference organised by one of the partner groups in the Bridging the GAP EPSRC initiative, EMBRACE at Imperial College. The purpose was to network with other groups and individuals involved in the AMR challenge.
Year(s) Of Engagement Activity 2016
URL http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/lifesciences/eventssummary/event_17-2-...
 
Description Lecture by Victoria Wells of Antibiotic Action on 'The global challenge of antimicrobial resistance'. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Victoria Wells of Antibiotic Action (http://antibiotic-action.com/ ) was invited to talk to the CHAIR network about the challenge of antimicrobial resistance. The lecture was open to the undergraduate cohort and was designed to bring a greater understanding of the challenge to a wider audience within the university. It was a successful event with approximately 45 attendees, followed by questions and discussion.
Year(s) Of Engagement Activity 2016
URL https://www.ussu.co.uk/Lists/News/DispFormNew.aspx?ID=1571
 
Description Meeting with Veterinary Medicines Directorate 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Prof Richard Curry and Prof Roberto La Ragione met with Prof Peter Borriello of the Veterinary Medicines Directorate on 22 January 2016. The meeting was to discuss the VMD's priorities in relation to the AMR research agenda. The meeting defined areas where collaboration may lead to impact and receive stakeholder input into the sandpit. The meeting also discussed the design and priorities to be covered in the planned Funding Sandpit for the CHAIR project.
Year(s) Of Engagement Activity 2016
URL https://www.gov.uk/government/organisations/veterinary-medicines-directorate
 
Description Microbiology conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Disruption of carbonic anhydrase increases the intracellular virulence of Mycobacterium tuberculosis and alters glycolysis. T. Mendum, R. Balhana, D. Beste, J. Mcfadden. EMBO conference "Tuberculosis 2016: Interdisciplinary research on tuberculosis and pathogenic mycobacteria" Paris, September, 2016.
Year(s) Of Engagement Activity 2016
 
Description NERC KEN 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Environmental Nanoscience Initiative Knowledge Exchange: the environmental and engineering voices in my head
NERC Knowledge Exchange Network meeting
2-3 Nov 2016
London, UK
Year(s) Of Engagement Activity 2016
 
Description Organised microbiology Society Emerging Threats and AMR meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Organised a Microbiology Society Surrey meeting on Emerging Threats and AMR.
Year(s) Of Engagement Activity 2018
 
Description Poster presentation at the EJP ASM 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster presentation at EJP ASM
Year(s) Of Engagement Activity 2019
 
Description Presentation at St George's hospital June 2018 - One health, Zoonoses and AMR 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Presentation at St George's hospital June 2018 - One health, Zoonoses and AMR
Year(s) Of Engagement Activity 2018
 
Description Reseacher Cafe held on 1st February 2017 sponsored by CHAIR 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact CHAIR sponsored a second researcher café following the successful event held in November. The Researcher Development Programme hold regular 'Researcher Cafes' to bring together postgraduate students and post doctoral researchers across the university. CHAIR specifically targeted those working in AMR to attend this café, as was done in November. It was a successful event, attended by approximately 30 people, a combination of PhD students, post-docs and also some academic staff working on CHAIR projects. It was good to see that CHAIR has successfully fostered interdisciplinary interaction at Surrey and good to see it in progress.
Year(s) Of Engagement Activity 2017
URL http://www.surrey.ac.uk/feps/research/themes/health/CHAIR/events/chair_sponsors_rdp_researcher_cafe2...
 
Description Researcher Cafe held on 16th November sponsored by CHAIR 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact CHAIR sponsored a Researcher Café (held on a regular basis by the Researcher Development Programme at the University of Surrey). The Researcher Cafes are designed to encourage networking among research staff and PhD students. The Researcher Café held on Wednesday 16th November was particularly advertised to try to attract those working in any field connected to AMR (microbiologists, chemical engineers) and also those working on the CHAIR small funded projects were invited, most of whom attended. It was a very good turnout of between 25 to 30 with plenty of discussion and interest. We also advertised further events during the next few weeks.
Year(s) Of Engagement Activity 2016
URL http://www.surrey.ac.uk/feps/research/themes/health/CHAIR/events/chair_researcher_cafe.htm
 
Description Science Delivering Global Wellbeing: Discoveries on your Doorstep 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Discoveries on your Doorstep was an event organised by the Research Development Programme and was designed to connect researchers at all levels with local professionals and policy makers. The first of the events was 'Science Delivering Global Wellbeing' and CHAIR had a stand at the event including a poster and leaflets promotion future events. There were 80 attendees in total and included people from local companies on the research park, among others. It was a useful way to not only highlight the challenge of antimicrobial resistance but also to showcase the work CHAIR is funding with EPSRC funds towards meeting the challenge. Some specific contacts were made.
Year(s) Of Engagement Activity 2016
URL https://www.surrey.ac.uk/surreynet/news/2016/167399_discoveries_on_your_doorstep_science_delivering_...
 
Description Seminar by Prof Elizabeth Wellington of Warwick University on Tuesday 13th December. 'Survival of pathogenic bacteria in the environment' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Prof Elizabeth Wellington of Warwick University https://www2.warwick.ac.uk/fac/sci/lifesci/people/ewellington/ gave a seminar on 'The Survival of Pathogenic Bacteria in the Environment. (There had been interest in the AMR aspect of water treatment and the environment at the last Sandpit from staff from Civil and Environmental Engineering.) Thirty academic staff and postgraduate students attended the seminar from various departments of the University, including civil and environmental engineering, chemistry, Surrey Business School, Bioscience and Medicine, ATI, Vet School, Nutrition and Computer Science. This was followed by networking for an hour and contacts were made with Warwick and also between departments.
Year(s) Of Engagement Activity 2016
URL http://www.surrey.ac.uk/feps/research/themes/health/CHAIR/events/chair_seminar_tuesday_13th_december...
 
Description Talk for Newton fund BBSRC meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk on the development of rapid diagnostics for poultry.
Year(s) Of Engagement Activity 2020
 
Description Talk for the ODN 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Talk on the alternatives to antibiotics for use in animals.
Year(s) Of Engagement Activity 2020
 
Description Talk for the RCGP on AMR a veterinary perspective 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact A talk on AMR for the RCGP's
Year(s) Of Engagement Activity 2018
 
Description Talk on the microbiome and AMR - European College of Veterinary Microbiology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk on microbiomes and AMR at the European College of Veterinary Microbiology Annual Conference.
Year(s) Of Engagement Activity 2019
 
Description UGPN Visit to University of Wollongong 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Richard Curry, PI, visited University of Wollongong from 28th February to 5th March 2016 with colleagues from Surrey University as part of the University Global Partnership Network. This includes University of Surrey, North Carolina State University, University of Sao Paolo and University of Wollongong has recently joined. The challenge of antimicrobial resistance was discussed with partners.
Year(s) Of Engagement Activity 2016
URL http://www.surrey.ac.uk/surreynet/news/2015/157890_university_of_wollongong_joins_ugpn.htm
 
Description Veterinary Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Systems approaches to new vaccines and diagnostics for bovine tuberculosis. Invited talk by Johnjoe McFadden.
Year(s) Of Engagement Activity 2016
URL http://www.vetvaccnet.ac.uk/publications/systems-approach-new-vaccines-and-diagnostics-bovine-tuberc...