Discrete computational modelling of twin screw granulation
Lead Research Organisation:
University of Surrey
Department Name: Chemical Engineering
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Chuan-Yu Wu (Principal Investigator) |
Publications
Tang X
(2020)
Data on rotary die filling performance of various pharmaceutical powders.
in Data in brief
Wu C
(2017)
On the submerging of a spherical intruder into granular beds
in EPJ Web of Conferences
Zhang L
(2020)
Discrete element analysis of normal elastic impact of wet particles
in Powder Technology
Zheng C
(2021)
DEM analysis of residence time distribution during twin screw granulation
in Powder Technology
| Description | A robust numerical method with rigorous contact models was developed and can be used to explore the mechanical behaviour of wet powder during handling and manufacturing. Full scale process modelling with physics-based models is enabled. |
| Exploitation Route | The model/tool has now been used on several collaborative project with industry, to further evaluate its robustness. |
| Sectors | Chemicals,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Description | we have presented our recent studies at conferences that were well received from industry, as they are now inspired to look into the use of computational approach in product development. Our research also convinced the industrial practitioners that the model we developed is of some value to their product development and promotes the uptake of this numerical tool. We are now running 3 industrial sponsored projects using the developed tool/models. Discrete element modelling (DEM) capabilities were significantly enhanced, which enables rigorous analysis of wet particle systems and robust simulations of full-scale twin screw granulators. The enhanced computational capabilities promote the up-take of this modelling technique in the pharmaceutical and food industry from which we have received direct industrial funding to explore the use of this technique in pharmaceutical manufacturing from Genentech and Janssen, as well as chocolate manufacturing from Mondelez. In addition, the enhanced computational capabilities also led to successful funding from EPSRC (e.g. EP/W027461) and EU H2020 (No. 813212) with a total budget over £5m. |
| Sector | Chemicals,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Cultural,Economic |
| Description | PDRA career development |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | DISPERSION AND DISSOLUTION OF HYDROCOLLOIDS |
| Amount | £749,741 (GBP) |
| Funding ID | EP/W027461/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2023 |
| End | 03/2026 |
| Description | H2020-MSCA-2016-IF |
| Amount | € 195,000 (EUR) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 09/2017 |
| End | 09/2019 |
| Description | IFPRI die filling |
| Amount | $114,000 (USD) |
| Organisation | International Fine Particles Research Institute Ifpri |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 11/2016 |
| End | 10/2019 |
| Description | MATHEGRAM - Multiscale Analysis of Thermomechanical Behaviour of Granular Materials |
| Amount | € 4,170,000 (EUR) |
| Funding ID | 813202 |
| Organisation | European Commission H2020 |
| Sector | Public |
| Country | Belgium |
| Start | 01/2019 |
| End | 12/2022 |
| Description | Migration of Pollutant Particles in Rivers: A Multiscale Approach |
| Amount | £99,000 (GBP) |
| Funding ID | 86203204 |
| Organisation | The Royal Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2018 |
| End | 12/2020 |
| Title | Modelling tool for wet particles |
| Description | A new numerical model for wet particle systems has been developed. this model has been validated extensively using experimental data. Papers are currently being written and will be published in the near future. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | This tool will enable wet particle systems to be model rigorously, based upon primarily the physical parameters. |
| Description | GENENTECH |
| Organisation | Genetech, Inc |
| Country | United States |
| Sector | Private |
| PI Contribution | Modelling capacity and expertise |
| Collaborator Contribution | Know-how and facility for pharmaceutical manufacturing |
| Impact | N/A |
| Start Year | 2019 |
| Description | Jansson |
| Organisation | Janssen Pharmaceutica NV |
| Country | Belgium |
| Sector | Private |
| PI Contribution | the computational model and know-how |
| Collaborator Contribution | know-how: pharmaceutical product development and manufacturing |
| Impact | Not yet, project only started a few months ago. |
| Start Year | 2020 |
| Description | UNIS PHD training programme |
| Organisation | Chinese Academy of Sciences |
| Department | Institute of Process Engineering |
| Country | China |
| Sector | Academic/University |
| PI Contribution | We will use the DEM models developed on this grant to run a few PhD projects in related areas. Currently, 9 PhD students were enrooled on this collaborative PhD prgramme with Unilever and Chinese Academy of Science. among which 2 project will directly use the model developed for basket granulation processes. |
| Collaborator Contribution | Unilever identify the research problem and offer materials and staff time to guide the studnets. Chinese Academy of Science host each PhD stidents up to 2 years and provide the stipends for those students and research facility during their secdment |
| Impact | n/a |
| Start Year | 2018 |
| Description | UNIS PHD training programme |
| Organisation | Unilever |
| Department | Unilever Research and Development |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We will use the DEM models developed on this grant to run a few PhD projects in related areas. Currently, 9 PhD students were enrooled on this collaborative PhD prgramme with Unilever and Chinese Academy of Science. among which 2 project will directly use the model developed for basket granulation processes. |
| Collaborator Contribution | Unilever identify the research problem and offer materials and staff time to guide the studnets. Chinese Academy of Science host each PhD stidents up to 2 years and provide the stipends for those students and research facility during their secdment |
| Impact | n/a |
| Start Year | 2018 |
| Title | Enhanced DEM software for wet systems |
| Description | with the implementation of the interaction law for wet particles, the in-house DEM software is now upgraded to model complex wet particle systems. |
| Type Of Technology | Software |
| Year Produced | 2017 |
| Impact | The enhanced software will be able to model complex wet particulate systems. |
| Description | Conference presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | This is an invited keynote talk to outline the potential of the use of computational tools in pharmaceutical developed at the 7th Annual Drug delivery and formulation Asia summit, presented to audience primarily from the pharmaceutical industry. |
| Year(s) Of Engagement Activity | 2007 |
| Description | International conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | An invited talk at the international conference on computational methods, at which the recent developed in modelling complex particulate systems and liquid-solid systems were discussed. |
| Year(s) Of Engagement Activity | 2017 |
| Description | International conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A keynote presentation on the use of hybrid computational tool for formulation and product design. |
| Year(s) Of Engagement Activity | 2017 |
| Description | keynote/plenary lectures |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | We have been invited to given 3 plenary and keynote lectures to present the work on this grant |
| Year(s) Of Engagement Activity | 2020,2021,2022 |