New routes to driving enzyme-catalysed chemical synthesis using hydrogen gas

Lead Research Organisation: University of Oxford
Department Name: Oxford Chemistry

Abstract

Bacterial cells act as miniature chemical factories and have evolved specialised routes to making many of the sorts of molecules that we use as pharmaceuticals, pleasant fragrances, food additives or chemicals for use in agriculture. The key parts of the cells for carrying out this work are the enzymes. It is possible to break cells open and isolate an enzyme for making a specific molecule. Bacteria can also be engineered to make artificial chemicals, expanding the range of molecules they can produce. Procedures are now well-established for growing bacteria on a large scale and isolating large quantities of enzymes, and at the same time, chemical companies are starting to realise the benefits of using enzymes instead of traditional chemical routes. In the production of complicated molecules such as drugs, fragrances and food flavourings, enzymes generate much less waste, make purer chemical products, and allow chemistry to be carried out in water rather than toxic, polluting solvents. The purity of the end product is particularly important in the food and pharmaceutical industries where contaminants may have serious, harmful effects.

Although there has been increasing interest in using enzyme catalysis in chemical production, many challenges remain to be overcome before this approach can be widely adopted. Once isolated from their cells, enzymes are often quite unstable. Their stability can be improved by attaching them to surfaces, but this often requires complicated attachment processes and can be expensive. Secondly, many enzymes only work in the presence of special helper-molecules called cofactors which are used up by the enzymes in the process of making chemicals. The cofactors are also expensive, and for enzyme processes to be economically viable, it is essential to have some way of recycling the cofactors. Unfortunately, the currently-available methods for recycling the cofactors make even more waste which contaminates the desired chemical products. We have developed a technology that addresses both of these challenges, offering a much-needed step change for enzyme catalysis. At the moment, our technology has only been demonstrated on a small scale in our laboratories, but we now need to convince the chemical, pharmaceutical and food industries that this offers real benefits for the future of chemical production.

Our technology works as follows: once we have isolated enzymes from the bacterial cells, we immediately attach them onto cheap carbon beads. This is a very simple one-step process. We attach several different types of enzyme to each bead so that the enzymes can work together to carry out each step in making chemicals. We supply the beads with low, safe levels of hydrogen gas, and this provides the energy for recycling the cofactors and to drive the enzyme machinery necessary to make the required chemicals. To make a desired chemical, we start by putting a cheap chemical building-block in water, we bubble in a little hydrogen gas, add our enzyme-modified beads, and after a few hours, the desired chemical product is ready to collect! The enzyme-modified beads can be easily scooped out of the reaction mixture, leaving nothing else except the desired product and a tiny trace of the harmless cofactor. As an added bonus, the beads can be collected and re-used a number of times, minimising the cost of using enzymes.

To take our concept from a lab-scale idea to a technology ready for industry to adopt, we need to show that we can produce the enzymes on a large scale. We need to show how quickly the beads can produce chemicals, and how pure the products are. This project will answer these sort of questions, so that at the end of the 5 years, we can convince potential customers (chemical, pharmaceutical and food additive companies) that our technology will allow them to make chemicals more cheaply and in a more environmentally-friendly way.

Planned Impact

As described in proposal submitted to IUK

Publications

10 25 50

 
Title HydRegen - biotechnology demo (YouTube video) 
Description Professionally produced film that documents a demo aimed toward school age children. The video also gives context for where enzymes play a role in our daily lives. 
Type Of Art Film/Video/Animation 
Year Produced 2019 
Impact 97 Youtube views 
URL https://www.youtube.com/watch?v=6wyJb8lDUgw
 
Title Meet the Team - Inside the HydRegen Labs (YouTube video) 
Description A professionally produced video was filmed in order to summarise the project and a typical timeline for production (enzyme growth, reaction verification, reaction scale up in batch and flow). 
Type Of Art Film/Video/Animation 
Year Produced 2019 
Impact 208 views on YouTube. 
URL https://www.youtube.com/watch?v=uX_109Fco2I&feature=emb_logo
 
Description The grant supported translation towards commercialisation of a biocatalysis technology for fine chemical synthesis. We made significant progress towards de-risking this technology, for example showing that the enzyme-modified HydRegen catalyst particles can be coupled with a range of different NADH dependent enzymes, operated over a wide pH range, and stored and transported readily. We demonstrated numerous applications of the HydRegen catalyst system in different areas of NADH-dependent biotechnology. We have generated further intellectual property, around use of the technology for inserting heavy isotopes of hydrogen, and around the recycling of reduced flavin cofactors.
Exploitation Route The funding has led to successful spin out of the company HydRegen Ltd. The aim of HydRegen is to develop technologies that allow cleaner, more sustainable, more efficient chemical manufacture.
Sectors Chemicals,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

URL https://hydregenoxford.com/
 
Description The research developed and translated on this award has led to spin out of a company, HydRegen Ltd in 2021, with IP licenced into the company. Further IP has been protected during the project, relating to flavin recycling and selective deuterium insertion, and this is being developed within the University of Oxford towards licensing in the future. Further confidential IP will be protected shortly, and is also under active development towards licensing.
First Year Of Impact 2021
Sector Chemicals,Manufacturing, including Industrial Biotechology
Impact Types Economic

 
Description BBSRC INDUSTRIAL CASE (iCASE) STUDENTSHIP, Interdisciplinary Bioscience DTP, University of Oxford
Amount £80,000 (GBP)
Funding ID Project 1946990, related to BB/M011224/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 08/2017 
End 08/2021
 
Description BBSRC INDUSTRIAL CASE (iCASE) STUDENTSHIP, University of Oxford
Amount £80,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2018 
End 09/2022
 
Description Biocatalysis for Sustainable Chemistry - Understanding Oxidation/Reduction of Small Molecules by Redox Metalloenzymes via a Suite of Steady State and Transient Infrared Electrochemical Methods
Amount € 2,980,000 (EUR)
Funding ID ERC-2018-COG 819580 
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 03/2019 
End 02/2023
 
Description Elements of Bioremediation, Biomanufacturing & Bioenergy (E3B): Metals in Biology
Amount £694,618 (GBP)
Funding ID BB/S009787/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 03/2019 
End 02/2024
 
Description Public Engagement with Research Undergraduate Bursary Award for Summer Project
Amount £2,000 (GBP)
Organisation University of Oxford 
Sector Academic/University
Country United Kingdom
Start 05/2018 
End 08/2018
 
Description The UK Catalysis Hub - 'Science': 1 - Optimising, predicting and designing new Catalysts
Amount £3,683,535 (GBP)
Funding ID EP/R026815/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 12/2018 
End 11/2023
 
Description The UK Catalysis Hub - 'Science': 2 Catalysis at the Water-Energy Nexus
Amount £4,010,674 (GBP)
Funding ID EP/R026645/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 12/2018 
End 11/2023
 
Title Biocatalytic reductive deuteration - selective insertion of heavy hydrogen isotope atoms into pharmaceuticals and other valuable chemicals 
Description We have developed a biocatalytic system for insertion of deuterium (heavy hydrogen isotope) atoms into very selective positions in chemicals. This is valuable to the NMR community (eg for labelling of amino acids for protein NMR); the neutron diffraction community (eg deuterated ligands or amino acids for preparing labelled proteins); the medicinal chemistry community (eg for preparation of deuterated drug fragments or APIs which have been shown to have better metabolic stability than their standard analogues). 
Type Of Material Technology assay or reagent 
Year Produced 2020 
Provided To Others? Yes  
Impact -high quality NMR structure for a 400 kDa heat shock protein solved in collaboration with Prof Andrew Baldwin -library of deuterated alanine derivatives prepared and made available via the Kerafast research chemicals platform -library of deuterated drug fragments prepared ready for metabolic stability testing -Publications -studentship awarded through the EPSRC-funded OxICFM CDT 
 
Title Hydrogen-driven flavin recycling method 
Description Hydrogen gas is used to regenerate the reduced, hydroquinone forms of flavin cofactors, FADH2 or FMNH2, for use in biotechnology with enzymes which will accept reducing equivalents from reduced flavins, such as ene reductases, nitro reductases and halogenases. 
Type Of Material Technology assay or reagent 
Year Produced 2020 
Provided To Others? Yes  
Impact Proof of concept project funded from BBSRC E3B NIBB. 
 
Description CPI 
Organisation Centre for Process Innovation (CPI)
Country United Kingdom 
Sector Private 
PI Contribution We provided lab-scale methods for enzyme preparation to CPI.
Collaborator Contribution CPI were engaged as sub-contractors and demonstrated scalable production of the enzymes needed for our HydRegen biocatalyst system.
Impact CPI demonstrated possibility of generating enzymes needed for our HydRegen biotechnology at scale, and this was crucial in allowing us to secure investment to take HydRegen forward into a spin out from University of Oxford.
Start Year 2018
 
Description Cofactor dependent biocatalysis for chemical synthesis 
Organisation Johnson Matthey
Country United Kingdom 
Sector Private 
PI Contribution We have tested a number of dehydrogenase enzymes from Johnson Matthey in conjunction with our H2-driven approach to NADH recycling; we have explored an inherent NAD+ recycling activity present in a number of samples of dehydrogenases.
Collaborator Contribution Johnson Matthey Catalysis and Chiral Technologies have supplied us with a large number of enzyme samples in kind. These include commercially available enzymes as well as newer enzymes from the JMCCT collection which are not yet commercially available.
Impact Enzyme provided in kind by JMCCT contributed to the following publications: (1) Zor, C., Reeve, H.A., Quinson, J., Thompson, L.A., Lonsdale, T.H., Dillon, F., Grobert, N., Vincent K.A., 'H2-driven Biocatalytic Hydrogenation in Continuous Flow using Enzyme-Modified Carbon Nanotube Columns', Chem. Commun., 2017, 53, 9839-9841; (2) Reeve, H.A., Ash, P.A., Park, H., Huang, A., Posidias, M., Tomlinson, C., Lenz, O., Vincent, K.A., 'Enzymes as modular catalysts for redox half reactions in H2-powered chemical synthesis: from biology to technology', Biochemical Journal, 2017, 474, 215-230; (3) Reeve, H.A., Lauterbach, L., Lenz, O., Vincent, K.A. 'Enzyme-Modified Particles for Selective Bio-Catalytic Hydrogenation via H2-driven NADH Recycling' ChemCatChem, 2015, 7, 21, 3480-3487.
Start Year 2014
 
Description Collaboration with Johnson Matthey 
Organisation Johnson Matthey
Country United Kingdom 
Sector Private 
PI Contribution Expertise in H2-linked recycling of the biological cofactors, NADH and NAD+ and flavins, and generally in biological redox reactions.
Collaborator Contribution In-kind contributions of custom enzymes for NADH-dependent catalysis, including alcohol dehydrogenases, aldehyde dehydrogenases, imine reductases, ene reductases, glucose dehydrogenase, nitro reductases; advise on biocatalytic reactions, and market landscape for biocatalysis.
Impact Publications acknowledging Dr Beatriz Dominguez of Johnson Matthey in the Acknowledgements: Zor, C., Reeve, H.A., Quinson, J., Thompson, L.A., Lonsdale, T.H., Dillon, F., Grobert, N., Vincent K.A., 'H2-driven Biocatalytic Hydrogenation in Continuous Flow using Enzyme-Modified Carbon Nanotube Columns', Chem. Commun., 2017, 53, 9839-9841 DOI:10.1039/C7CC04465H J.S. Rowbotham, M.A. Ramirez, O. Lenz, H.A. Reeve, K.A. Vincent, 'Bringing biocatalytic deuteration into the toolbox of asymmetric isotopic labelling techniques', Nature Communications, 2020, 11, 1454, DOI: 10.1038/s41467-020-15310-z Reeve, H.A., Ash, P.A., Park, H., Huang, A., Posidias, M., Tomlinson, C., Lenz, O., Vincent, K.A., 'Enzymes as modular catalysts for redox half reactions in H2-powered chemical synthesis: from biology to technology', Biochemical Journal, 2017, 474, 215-230. DOI:10.1042/BCJ20160513 J.S. Rowbotham, H.A. Reeve, K.A. Vincent, 'Hybrid Chemo-, Bio-, and Electrocatalysis for Atom-Efficient Deuteration of Cofactors in Heavy Water', ACS Catalysis, 2021, 11, 2596-2604, DOI: 110.1021/acscatal.0c03437 Joseph Srinivasan, S., Cleary, S.E., Ramirez, M., Reeve, H.A., Paul, C., Vincent, K.A. 'E. coli Nickel-Iron Hydrogenase 1 Catalyses Non-native Reduction of Flavins: Demonstration for Alkene Hydrogenation by Old Yellow Enzyme Ene-reductases', Angew. Chemie Int. Ed., 2021, 60, 13824-13828; DOI: 10.1002/anie.202101186 B. Poznansky, S.E. Cleary, L.A. Thompson, H.A. Reeve, K.A. Vincent 'Boosting the Productivity of H2-Driven Biocatalysis in a Commercial Hydrogenation Flow Reactor Using H2 From Water Electrolysis' Frontiers in Chemical Engineering, 2021, 3, DOI: 10.3389/fceng.2021.718257
Start Year 2015
 
Description Dr Caroline Paul, TU Delft 
Organisation Delft University of Technology (TU Delft)
Department Department of Biotechnology
Country Netherlands 
Sector Academic/University 
PI Contribution We have developed H2-driven cofactor recycling systems suitable for trial with enzymes from Dr Caroline Paul's labs.
Collaborator Contribution Dr Caroline Paul has developed new C=C bond reducing enzymes suitable for coupling to our cofactor recycling systems, and artificial cofactor systems suitable for trial with our cofactor recycling catalysts.
Impact Joint Publication: Joseph Srinivasan, S., Cleary, S.E., Ramirez, M., Reeve, H.A., Paul, C., Vincent, K.A. 'E. coli Nickel-Iron Hydrogenase 1 Catalyses Non-native Reduction of Flavins: Demonstration for Alkene Hydrogenation by Old Yellow Enzyme Ene-reductases', Angew. Chemie Int. Ed., 2021, 60, 13824-13828, DOI: 10.1002/anie.202101186. Dr Paul and Prof Vincent are co-editing a journal issue on biotechnology. A further publication is in progress.
Start Year 2018
 
Description Dr Reddy's 
Organisation Dr. Reddy's Laboratories
Country India 
Sector Private 
PI Contribution I have spent a month at Dr Reddy's as part of my DPhil Project. I will spend a further 2 months there, this year.
Collaborator Contribution Dr Reddy's have provided lab space, equipment, and directional input on my project. They also provided some data for our joint publication.
Impact 1 publication listed in the publication section
Start Year 2017
 
Description Programme Access to MIRIAM Infrared Microspectroscopy Beamline B22 at Diamond Light Source 
Organisation Diamond Light Source
Country United Kingdom 
Sector Private 
PI Contribution We have contributed expertise in handling and electrochemical manipulation of hydrogenase single crystals, and in infrared microscopy studies of protein single crystals. We have developed an electrochemical - infrared microspectroscopy cell for handling single protein crystals which we will make available to other users on the beamline B22 at Diamond Light Source.
Collaborator Contribution Beamline scientists Dr Giangfelice Cinque and Mark Frogley at B22 contributed expertise in syncrotron IR microspectroscopy.
Impact Multidisciplinary, across biochemistry, chemistry and physics. Ash, P.A., Carr, S.B., Reeve, H.A., Skorupskaite, A., Rowbotham, J.S., Shutt, R., Frogley, M.D., Evans, R.M., Cinque, G., Armstrong, F.A., Vincent, K.A.,'Shocking protein crystals into action: combining electrochemistry and infrared microscopy provides insight into [NiFe] hydrogenase mechanism', Diamond Light Source Annual Review, 2017/2018, page 84. P.A. Ash,* S.E.T. Kendall-Price, R.M. Evans, S.B. Carr, A. Brasnett, S. Morra, J. Rowbotham, R. Hidalgo, A.J. Healy, G. Cinque, M.D. Frogley, F.A. Armstrong, K.A. Vincent* 'The crystalline state as a dynamic system: IR microspectroscopy under electrochemical control for a [NiFe] hydrogenase' Chemical Science DOI: 10.1039/D1SC01734A
Start Year 2018
 
Description Stoli Chem 
Organisation Stoli Chem
Country United Kingdom 
Sector Private 
PI Contribution BBSRC iCASE studentship secured to start in October 2021 with Stoli Chem to implement biocatalysis in their flow reactors. Expands the scope of reactions that they have demonstrated in their reactors.
Collaborator Contribution In-kind contributions of access to scaled reactors for the studentship project, discussions and advice.
Impact BBSRC iCASE studentship between University of Oxford Interdisciplinary Bioscience DTP and Stoli Chem
Start Year 2020
 
Title COFACTOR REGENERATION SYSTEM 
Description European Patent Granted 5 December 2018 to protect a cofactor recycling system, using electrically conducting supports modified with enzymes for hydrogen-driven NADH recycling. 
IP Reference EP2764107 
Protection Patent granted
Year Protection Granted 2014
Licensed No
Impact HydRegen Ltd, company spun out to commercialise this IP. Patent licensed to HydRegen Ltd in 2021.
 
Title METHOD FOR PRODUCING A DEUTERATED OR TRITIATED NAD(P)H 
Description The invention relates to a method of producing a reduced labelled cofactor comprising one or more xH atom, wherein x is 2 or 3. The invention also relates to a method of producing a reduced labelled reaction product comprising one or more xH atom, wherein x is 2 or 3, wherein the method comprises producing a reduced labelled cofactor according to the invention. The invention also relates to systems for performing such methods. 
IP Reference WO2019155089 
Protection Patent application published
Year Protection Granted 2019
Licensed No
Impact No impact yet, but likely to be licensed to HydRegen Ltd in the future.
 
Company Name HYDREGEN LIMITED 
Description HydRegen's biotechnology platform offers cleaner, safer, faster chemical manufacture, blending exquisite precision with efficient processing. HydRegen is a spin out of the University of Oxford, and holds an exclusive licence to a patent protecting a novel biotechnology (patent number: WO2013050760 A2, granted in EU and US). Our goal is to enable customers in the chemicals sector to replace toxic heavy metals, decarbonise biocatalysis and speed up adoption of flow processes. We will achieve this by: • selling R&D scale products that lower the barrier-to-entry for biocatalysis, • carrying out contract research for sale of tailored products, and • offering packages of product sales, contract research and technology licences for commercial processes We have secured £420k (Innovate UK and University Seed Challenge Fund) for 18 months of industrial research and development. We expect to launch our first commercial product within our first year, and to enter our first commercial licencing deal within 18 months. 
Year Established 2020 
Impact too early to state
 
Description 'A collaborative journey to greener chemicals' - Article for Adjacent Government 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Wrote an article about the impact that RCUK funding has had on our research and the potential impact of our research. Article highlights the benefit of funding for collaborations with Industry and the impact this can have on development of innovative technologies, specifically in the biotech sector.
Year(s) Of Engagement Activity 2016
URL http://www.adjacentopenaccess.org/farming-environment-marine-sustainable-news/collaborative-journey-...
 
Description 'Award-winning HydRegen technology offers path to 'clean, safe' chemical production' - Article on University's Science Blog 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact The University of Oxford's media team wrote an article about the HydRegen Technology to promote the research to a wide audience.
Year(s) Of Engagement Activity 2016
URL http://www.ox.ac.uk/news/science-blog/award-winning-hydregen-technology-offers-path-clean-safe-chemi...
 
Description 'Cleaner greener method for making lab chemicals' - Radio Show (The Science Show on Australian Broadcasting Commission) 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Kylie Vincent and Holly Reeve were interviewed by Robyn Williams on the ABC radio show - The Science Show. This show has a large audience in Australia and world wide.The purpose of the interview was to explain the HydRegen technology to a general, but scientifically interested, audience. This has led to an increase in awareness of our work, biocatalysis and industrial biotechnology internationally.
Year(s) Of Engagement Activity 2016
URL http://www.abc.net.au/radionational/programs/scienceshow/cleaner-greener-method-for-making-lab-chemi...
 
Description 'Learning from nature' - podcast on the University of Oxford's 'Big Questions' series 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A podcast about how bacteria may hold the key to using hydrogen as a clean energy source, both as a fuel and as a route to chemicals.
Year(s) Of Engagement Activity 2016
URL http://www.oxfordsparks.ox.ac.uk/content/learning-3-learning-nature
 
Description 2018 STEM Christmas Lecture at Natural History Museum, Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact PDRA on the project, Jack Rowbotham, gave the Annual STEM Christmas Lecture at the Natural History Museum, Oxford. Around 100 secondary school students attended.
Year(s) Of Engagement Activity 2018
 
Description Animation and teaching resources 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Created an animation with the University public engagement team. The animation highlights the importance of industrial biotechnology as well as the technology developed as part of this project. Resources for schools were also produced. This animation was put on social media by the University of Oxford and reached more than 10,000 views in the first month.
Year(s) Of Engagement Activity 2017
URL http://www.oxfordsparks.ox.ac.uk/content/what-can-chemists-learn-nature
 
Description Annual Women in Science event at Jesus College, Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Lecture to inspire female 6th form school students about applying to STEM subjects at University, presented by project PDRA, Lisa Thompson.
Year(s) Of Engagement Activity 2019
 
Description Asynt Drysyn OCTO press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Representatives from Asynt were onsite to photograph and interview Sarah Cleary about her use of the Drysyn OCTO reactor in the optimisation of the H2-driven enzyme system.
Year(s) Of Engagement Activity 2019
URL https://www.asynt.com/press-releases/biocatalytic-hydrogenation-optimisation/
 
Description Christmas lecture Oxford Museum of Natural History 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact "Biocatalysis with all the trimmings" - lecture to introduce the concepts behind industrial biotechnology through common examples behind a Christmas Dinner (e.g. digestive enzymes).
Year(s) Of Engagement Activity 2019
 
Description Exhibit at the University of Oxford's European Researchers' Nigh event - Curiosity Carnival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact We held an exhibit at the Curiosity Carnival in the Natural History Museum (Oxford). More than 2000 people attending during the evening. Our exhibit - What can Chemists Learn from Nature? centered on bio-inspired technologies. We had a game where people could match technologies to the bit of nature that inspired it, we showcased the animation we have produced about the area of industrial biotechnology and we performed live experiments (#RacingEnzymes) to show how nature can be intensified in the lab to make the chemicals we need. The event sparked questions and discussions in the area of industrial biotechnology and inspired students about the meeting point of the sciences as well as the overlap between academia and industry.
Year(s) Of Engagement Activity 2017
URL http://www.ox.ac.uk/curiosity-carnival/about
 
Description STEM Christmas lecture for 300 year 10 students 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Gave a presentation called: Inspired by nature: from planes and trains, to your box of Christmas chocolates! 300 students attended.
Year(s) Of Engagement Activity 2017
 
Description School outreach demonstration and lecture 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Research-related demonstrations and lectures given to 5 secondary classes at Hodge Hill Girls School, Birmingham, to inspire female students to consider careers in STEM and educate them about research in biotechnology.
Year(s) Of Engagement Activity 2018
 
Description Smarter Smells - Interview for a Chemistry World article 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Interviewed for a Chemistry World articles abut biocataylsis for the production of flavour and fragrances.
Year(s) Of Engagement Activity 2016
URL https://www.chemistryworld.com/feature/smarter-smells/1017487.article
 
Description YouTube channel to promote biotechnology research 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Series of podcasts and animations educating the public about biotechnology
Year(s) Of Engagement Activity 2018
URL https://www.youtube.com/channel/UCq9YqdQt4oLtXZ1Y94a7-uw