EPSRC Centre for Predictive Modelling in Healthcare

Lead Research Organisation: University of Exeter
Department Name: Engineering Computer Science and Maths

Abstract

Our Centre brings together a world leading team of mathematicians, statisticians and clinicians with a range of industrial partners, patients and other stakeholders to focus on the development of new methods for managing and treating chronic health conditions using predictive mathematical models. This unique approach is underpinned by the expertise and breadth of experience of the Centre's team and innovative approaches to both the research and translational aspects.

At present, many chronic disorders are diagnosed and managed based upon easily identifiable phenomena in clinically collected data. For example, features of the electrical activity of the heart of brain are used to diagnose arrhythmias and epilepsy. Sampling hormone levels in the blood is used for a range of endocrine conditions, and psychological testing is used in dementia and schizophrenia. However, it is becoming increasingly understood that these clinical observables are not static, but rather a reflection of a highly dynamic and evolving system at a single snapshot in time. The qualitative nature of these criteria, combined with observational data which is incomplete and changes over time, results in the potential for non-optimal decision-making.

As our population ages, the number of people living with a chronic disorder is forecast to rise dramatically, increasing an already unsustainable financial burden of healthcare costs on society and potentially a substantial reduction in quality of life for the many affected individuals. Critical to averting this are early and accurate diagnoses, optimal use of available medications, as well as new methods of surgery. Our Centre will facilitate these through developing mathematical and statistical tools necessary to inform clinical decision making on a patient-by-patient basis. The basis of this approach is patient-specific mathematical models, the parameters of which are determined directly from clinical data obtained from the patient. As an example of this, our recent research in the field of epilepsy has revealed that seizures may emerge from the interplay between the activity in specific regions of the brain, and the network structures formed between those regions. This hypothesis has been tested in a cohort of people with epilepsy and we identified differences in their brain networks, compared to healthy volunteers. Mathematical analysis of these networks demonstrated that they had a significantly increased propensity to generate seizures, in silico, which we proposed as a novel biomarker of epilepsy. To validate this, an early phase clinical trial at King's Health Partners in London has recently commenced, the success of which could ultimately lead to a revolution in diagnosis of epilepsy by enabling diagnosis from markers that are present even in the absence of seizures; reducing time spent in clinic and increasing accuracy of diagnosis. Indeed it may even make diagnosis in the GP clinic a reality.

However, epilepsy is just the tip of the iceberg! Patient-specific mathematical models have the potential to revolutionise a wide range of clinical conditions. For example, early diagnosis of dementia could enable much more effective use of existing medication and result in enhanced quality and quantity of life for millions of people. For other conditions, such as cortisolism and diabetes where a range of treatment options exist, identifying the optimal medication, and the pattern of its delivery, based upon the profile of the individual will enable us to maximise efficacy, whilst minimising unwanted side effects.

Planned Impact

Building on a substantial track-record of engagement with end-users (including patients and their carers, clinicians, device manufacturers and diagnostics companies, the pharmaceutical industry and funding agencies) we have developed a set of activities for User engagement that will build upon the research core of the Centre and form the basis of future impact. These activities include:

- bespoke training and a visitor programme (for both clinical researchers and practitioners) to introduce key concepts and to develop understanding of predictive models; a key first step to facilitate the ultimate uptake of these methods in practice
- researcher exchanges where members of the Centre and researchers from our industry partners will spend time working on projects of mutual interest
- "hot topics" workshops and sandpits where groups of scientists and clinicians spend a focused period discussing the very latest findings and challenges and suggest a roadmap for future travel
- "research incubator" retreats. Here we will bring mathematicians, clinicians and clinical scientists together with relevant industry to develop proposals for pump-priming new areas of research. This will be facilitated by our industry partner Life Sciences SouthWest and members of the Universities' Research & Knowledge Transfer teams, focused on research development, impact and commercialisation will help teams to develop bids and budgets to maximise the likelihood of substantive impact arising from these projects

Having utilised similar activities to establish a strong track-record of partnering with clinicians and industry already, we foresee substantial impact in the areas of epilepsy diagnostics and dynamic treatments for cortisolism arising during the initial period of EPSRC funding. In epilepsy, we have already taken steps to protect intellectual property through patenting the concept that time-varying changes in a network model of electroencephalography can predict clinical outcomes (joint patent between the University of Exeter and King's College London). We are currently undertaking an early phase clinical trial to validate this hypothesis. From here there is the opportunity for commercialisation, either linking with our project partner MentisCura or through a University spin-out company. To explore this latter option, we have recently secured SetSquared funding through their innovation to commercialisation scheme. Similarly, we have also patented a device for the dynamic delivery of hormone replacement with our project partner DesignWorks. Here we are exploring whether dynamic delivery of steroids - that mimic the natural secretory patterns in healthy humans - will optimise therapeutic benefit, whilst reducing significant side effects associated with long-term steroid use. Building closed loop systems based upon sensing precursor hormones offers significant potential for a dramatic impact for people with adrenal dysfunction. Building on this experience we also foresee impact in the areas of cardiology (notably arrhythmias), dementia and diabetes where we have developing collaborations with internationally leading clinical partners.

Research arising in our Centre will present the opportunity for impact for other commercial sector R&D. For example, parameter evolution of a patient-specific models extracted from clinical data brings the ability to characterise the effect of a drug or neuromodulation device. Similarly, it may be possible to develop biomarkers for response to newly developed compounds in early-stage trials, based upon parameter evolution of a patient-specific model. Based on our track-record to date, there will also be opportunities for industries focussed on device development and technologies for aiding clinical decision making. Our approach to co-develop the research focus and design of methodologies will ensure the development of mathematical and statistical methodologies that are challenge led and readily translatable.

Publications

10 25 50
 
Title Beyond My Control - Theatre Production in 2017 & National Tour in 2018 
Description Science meets theatre in this interactive modelling performance about epilepsy, excitability and all things neurological. Can mathematicians at the University of Exeter abandon their computers and recreate complex brain networks using theatre improvisation techniques? Can the logical world of mathematics and the unpredictable world of theatre come together to help us see what's really going on inside our heads? This production combines improvised scenes, verbatim testimony and top mathematical research in a unique theatrical experience engaging with epilepsy. Audience members will be invited to offer feedback and the chance to interact with the performance, as we explore just how much control we have over our brains. The 2017 IMPACT workshop was funded by the EPSRC (Engineering & Physical Sciences Research Council). IMPACT is a collaborative programme using the medium of performance to facilitate public engagement for the University of Exeter's world class research.The 2018 national tour was funded by the Exeter Northcott Theatre and the University of Exeter's Open Innovation Impact Fund 2017-18. 
Type Of Art Artistic/Creative Exhibition 
Year Produced 2017 
Impact Improving the broader understanding of our research and the impact it has on epilepsy diagnosis and prognosis. Sharing our research with the public. 
URL https://www.beyondmycontrol.co.uk/
 
Description Membership of ILAE Taskforce on Network Diseases
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
URL https://www.ilae.org/about-ilae/topical-commissions/commission-on-neurobiology/members#subcommittee-...
 
Description A novel mechanism underlying GnRH pulse generation by KNDy neurones
Amount £370,362 (GBP)
Funding ID BB/S001255/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 11/2018 
End 09/2020
 
Description A pilot study using movement and perspective-taking as a diagnostic aid for psychosis - Research Capability Funding
Amount £4,131 (GBP)
Organisation Avon and Wiltshire Mental Health Partnership NHS Trust 
Sector Public
Country United Kingdom
Start 09/2017 
End 07/2018
 
Description An integrative approach to understanding the GnRH pulse generator: combining in-vitro, in-vivo and in-silico methodologies.
Amount £49,600 (GBP)
Funding ID BB/S019979/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2019 
End 03/2023
 
Description BioEP - Proof of Concept. Innovate UK Health and Life Sciences - Round 2.
Amount £159,710 (GBP)
Funding ID 103939 
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 10/2018 
End 04/2020
 
Description Career Development Award
Amount £830,679 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2016 
End 02/2021
 
Description Celebrating New Appointments
Amount £500 (GBP)
Organisation London Mathematical Society 
Sector Learned Society
Country United Kingdom
Start 04/2018 
End 04/2018
 
Description Celebrating New Appointments
Amount £500 (GBP)
Organisation London Mathematical Society 
Sector Learned Society
Country United Kingdom
Start 04/2018 
End 04/2018
 
Description Chromatin Structure and Function Course - Training Grant
Amount £1,000 (GBP)
Organisation The Genetics Society 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2018 
End 11/2018
 
Description Chromatin Structure and Function Course - Travel Bursary
Amount £200 (GBP)
Organisation Wellcome Genome Campus 
Start 10/2018 
End 11/2018
 
Description Confidence in Concept
Amount £49,876 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 06/2016 
End 01/2017
 
Description EPSRC Early Career Researcher scheme
Amount £15,000 (GBP)
Organisation University of Exeter 
Sector Academic/University
Country United Kingdom
Start 09/2016 
End 03/2017
 
Description EPSRC Fellowship
Amount £639,000 (GBP)
Funding ID EP/N023544/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 01/2017 
End 12/2021
 
Description EPSRC Global Challenges Research Fund
Amount £14,993 (GBP)
Organisation University of Exeter 
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 03/2017
 
Description EPSRC Global Challenges Research Fund
Amount £15,000 (GBP)
Organisation University of Exeter 
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 03/2017
 
Description EPSRC Impact Acceleration Account
Amount £34,500 (GBP)
Organisation University of Exeter 
Sector Academic/University
Country United Kingdom
Start 01/2017 
End 03/2017
 
Description EU Horizon 2020 Programme TiPES (Pete Ashwin)
Amount £500,000 (GBP)
Funding ID 820970 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 09/2019 
End 08/2023
 
Description Entrepreneur in Residence Scheme
Amount £20,000 (GBP)
Organisation Royal Society of Medicine 
Sector Learned Society
Country United Kingdom
Start 08/2018 
End 07/2020
 
Description First Grant - Quantifying uncertainty in perturbed brain networks: towards a decision support tool for epilepsy surgery
Amount £100,000 (GBP)
Funding ID EP/P021417/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 07/2017 
End 06/2019
 
Description GW4 Initiator Fund
Amount £12,740 (GBP)
Organisation GW4 
Sector Academic/University
Country United Kingdom
Start 01/2018 
End 06/2018
 
Description ICURe Innovation-to-Commercialisation programme
Amount £35,000 (GBP)
Organisation SETsquared Partnership 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2017 
End 01/2018
 
Description Identifying characteristics and behaviours associated with alert fatigue in a clinical decision support system to develop strategies to optimise the user interaction. (MRC Proximity to Discovery)
Amount £25,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 09/2019
 
Description Impact Acceleration Account
Amount £30,507 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 02/2018 
End 07/2018
 
Description Impact Incubator
Amount £5,000 (GBP)
Organisation University of Exeter 
Sector Academic/University
Country United Kingdom
Start 06/2016 
End 07/2016
 
Description Institutional Sponsorship for Global Challenge Research Fund (GCRF) 2017-12018
Amount £8,350 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 10/2017 
End 03/2018
 
Description International Exchange Programme (with the University of Melbourne)
Amount £12,000 (GBP)
Organisation The Royal Society 
Sector Academic/University
Country United Kingdom
Start 09/2017 
End 08/2019
 
Description Jean Golding Institute Seed Corn Funding
Amount £3,249 (GBP)
Organisation University of Bristol 
Department Jean Golding Institute
Sector Academic/University
Country United Kingdom
Start 12/2017 
End 06/2018
 
Description Krasimira Tsaneva-Atanasova Fellowship
Amount £27,740 (GBP)
Organisation Alan Turing Institute 
Sector Academic/University
Country Unknown
Start 10/2018 
End 09/2020
 
Description MRC Proximity to Discovery
Amount £27,588 (GBP)
Organisation University of Exeter 
Sector Academic/University
Country United Kingdom
Start 11/2016 
End 08/2017
 
Description MRC Skills Development Fellowships - University of Exeter
Amount £1,800,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2017 
End 09/2021
 
Description Marsden Fund 2017
Amount $545,000 (NZD)
Organisation Royal Society of New Zealand 
Department Marsden Fund
Sector Academic/University
Country New Zealand
Start 09/2018 
End 09/2021
 
Description Network Funding
Amount £284,009 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 01/2017 
End 12/2018
 
Description Network on Emergence and Physics far from Equilibrium
Amount £1,920 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 06/2017 
End 05/2018
 
Description Newton Mobility Grant
Amount £12,000 (GBP)
Organisation The Royal Society 
Sector Academic/University
Country United Kingdom
Start 09/2017 
End 09/2019
 
Description Newton PhD Programme
Amount £10,000 (GBP)
Organisation Newton Fund 
Sector Public
Country United Kingdom
Start 02/2018 
End 03/2019
 
Description Peter Challenor Fellowship
Amount £17,003 (GBP)
Organisation Alan Turing Institute 
Sector Academic/University
Country Unknown
Start 10/2018 
End 09/2020
 
Description Research-Led Initiative Award - Open and Reproducible Science Workshop 2019
Amount £1,000 (GBP)
Organisation University of Exeter 
Sector Academic/University
Country United Kingdom
Start 05/2019 
End 07/2019
 
Description Skills Development Fellowship
Amount £414,663 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 07/2017 
End 06/2020
 
Description Skills Development Fellowship
Amount £260,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 06/2016 
End 05/2019
 
Description Skills Development Fellowship
Amount £395,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 07/2017 
End 06/2020
 
Description Wellcome Trust - A multiphoton Imaging Facility
Amount £584,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2016 
End 08/2021
 
Description Wellcome Trust Institutional Strategic Support Fund
Amount £1,500,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2016 
End 09/2021
 
Description World Congress of Psychiatric Genetics - Travel Bursary
Amount £400 (GBP)
Organisation Guarantors of Brain 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2018 
End 10/2018
 
Title Mutual Information Estimation - MATLAB Code 
Description Mutual Information Estimation - MATLAB Code 
Type Of Material Computer model/algorithm 
Year Produced 2017 
Provided To Others? Yes  
Impact Shared processes 
URL https://ore.exeter.ac.uk/repository/handle/10871/27843
 
Description Avon and Wiltshire Mental Health Partnership NHS Trust 
Organisation Avon and Wiltshire Mental Health Partnership NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution Working in collaboration with the University of Bristol on the project "A pilot study using movement and perspective-taking as a diagnostic aid for psychosis"
Collaborator Contribution Working in collaboration with the University of Exeter on the project "A pilot study using movement and perspective-taking as a diagnostic aid for psychosis"
Impact Research Capability Funding, Avon and Wiltshire Mental Health Partnership NHS Trust (in collaboration with University of Bristol). "A pilot study using movement and perspective-taking as a diagnostic aid for psychosis"
Start Year 2017
 
Description Bristol Heart Institute 
Organisation Bristol Heart Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Collaborations
Collaborator Contribution Sharing of data
Impact None yet
Start Year 2016
 
Description Devon Partnership NHS Trust 
Organisation Devon Partnership NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution Collaborations
Collaborator Contribution Collaborations
Impact None yet
Start Year 2017
 
Description First Data Bank Ltd 
Organisation First Databank Europe Ltd
PI Contribution (PI) MRC Proximity to Discovery. Title: Identifying characteristics and behaviours associated with alert fatigue in a clinical decision support system to develop strategies to optimise the user interaction, collaboration with First Data Bank Ltd 14/01/2019 - 14/11/2019
Collaborator Contribution See above
Impact TBC
Start Year 2019
 
Description IBM Research - Haifa 
Organisation IBM
Department IBM Research Haifa
Country Israel 
Sector Private 
PI Contribution Involvement in international research exchanges and coordination of a joint workshop
Collaborator Contribution Employee time, software availability, hosting researchers, sending researchers to the University of Exeter
Impact No impact yet, early stage collaboration
Start Year 2016
 
Description Kings College London 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Krasimira Tsaneva-Atanasova (Co-I) BBSRC US Partnering Award BB/S019979/1. Title: An integrative approach to understanding the GnRH pulse generator: combining in-vitro, in-vivo and in-silico methodologies, collaboration with Kings College London 01/04/2019 - 30/03/2023
Collaborator Contribution See above
Impact TBC
Start Year 2019
 
Description Kings College London 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Krasimira Tsaneva-Atanasova (PI) BBSRC grant BB/S001255/1. Title: A novel mechanism underlying GnRH pulse generation by KNDy neurones, collaboration with Kings College London 14/11/2018 - 14/10/2021
Collaborator Contribution See above
Impact TBC
Start Year 2018
 
Description Mayo Clinic, Rochester 
Organisation Mayo Clinic
Country United States 
Sector Charity/Non Profit 
PI Contribution Researcher visits
Collaborator Contribution Hosting researchers, providing epilepsy data
Impact No outputs yet
Start Year 2016
 
Description Northcott Theatre 
Organisation Northcott Theatre
Country United Kingdom 
Sector Private 
PI Contribution Direct staff costs - to co-direct initial scoping week and to participate in the public engagement and leadership events. Also to organise epilepsy outreach activity and to involve people with epilepsy in project development.
Collaborator Contribution Scoping and leadership for the project, actor/director fees, stage set up fees, hire costs, audition costs
Impact To increase public understanding of epilepsy and to reduce the stigma around epilepsy. To develop a public engagement activity that introduces theoretical concepts such as networks, dynamics, excitation, inhibition and perturbations and their relationship to brain dynamics and epilepsy in a dynamic interactive audio-visual environment. to develop a leadership and team-building course where the organizational structure of a company and the preferences of its employees form the basis of an initial network that team members are then able to adapt and evolve to form an optimal outcome.
Start Year 2016
 
Description Pontifical Catholic University of Rio Grande do Sul 
Organisation Pontifical Catholic University of Rio Grande do Sul
Country Brazil 
Sector Academic/University 
PI Contribution Researcher exchanges to further epilepsy research
Collaborator Contribution As above
Impact No outputs yet
Start Year 2016
 
Description Taunton and Somerset NHS Trust 
Organisation Taunton and Somerset NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution 50% funding for PhD student Robert Challen
Collaborator Contribution 50% funding for PhD student Robert Challen
Impact None yet
Start Year 2017
 
Description University Hospital of Bern, Switzerland 
Organisation University Hospital of Bern
Country Switzerland 
Sector Hospitals 
PI Contribution Researcher exchanges
Collaborator Contribution Researcher exchanges
Impact None as yet
Start Year 2017
 
Description University of Melbourne 
Organisation University of Melbourne
Country Australia 
Sector Academic/University 
PI Contribution We have undertaken mutual researcher exchanges to further epilepsy research.
Collaborator Contribution See previous
Impact Miegunyah Distinguished Visiting Fellowship MRC Strategic Skills Fellowship Application
Start Year 2016
 
Description 2nd International Neural Dynamics Summer School, Bristol 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Krasimira Tsaneva-Atanasova: Main Organiser, Bristol University, UK
Year(s) Of Engagement Activity 2018
 
Description 2nd International Neural Dynamics Summer School, Bristol 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Held at Bristol University. Krasimira Tsaneva-Atanasova - main organiser.
Year(s) Of Engagement Activity 2018
 
Description ASME funded Advanced Summer School on Continuation Methods for Nonlinear Problems, UIUC. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Jan Sieber - Co-organiser and lecturer. Held at University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
Year(s) Of Engagement Activity 2018
 
Description Beyond My Control - 2018 Tour 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Beyond My Control went on a 6 theatre tour (Liverpool, Lincoln, London, Exeter, Swindon and Aberystwyth) - the production explores the mathematics behind seizure generation and the shows were attended by nearly 800 people across the country.
Year(s) Of Engagement Activity 2018
URL https://www.beyondmycontrol.co.uk
 
Description Beyond My Control - Theatre Production 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Science meets theatre in this interactive modelling performance about epilepsy, excitability and all things neurological. Can mathematicians at the University of Exeter abandon their computers and recreate complex brain networks using theatre improvisation techniques? Can the logical world of mathematics and the unpredictable world of theatre come together to help us see what's really going on inside our heads? This production combines improvised scenes, verbatim testimony and top mathematical research in a unique theatrical experience engaging with epilepsy. Audience members will be invited to offer feedback and the chance to interact with the performance, as we explore just how much control we have over our brains. This IMPACT workshop is funded by the EPSRC (Engineering & Physical Sciences Research Council). IMPACT is a collaborative programme using the medium of performance to facilitate public engagement for the University of Exeter's world class research.
Year(s) Of Engagement Activity 2017
 
Description BioDynamics Workshop 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact The third international BioDynamics Workshop was designed to bring together biologists, mathematicians, clinicians, physicists, and computer scientists who are interested in dynamics and networks in the biological and medical sciences. It provided an opportunity for scientists to present both methods and data in a multidisciplinary forum and hear how interdisciplinary collaborations can provide major conceptual advances in our understanding of complex biomedical systems. The workshop boasted an exciting list of keynote speakers from all over the world.
Year(s) Of Engagement Activity 2016
URL http://www.bio-dynamics.org/events/biodynamics-2016
 
Description Brainwaves - stand at Sidmouth Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Yolanda Hill - organiser
Year(s) Of Engagement Activity 2018
 
Description Cardiac 'SATNAV' Destination: Heart attack damage. Soapbox Science. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Contributed talk by Yolanda Hill at Soapbox Science event in Exeter
Year(s) Of Engagement Activity 2018
 
Description Centre launch event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact The aim of the event was to introduce and give an overview of the work the Centre will be doing. It also provided a good networking opportunity for those that wanted to engage and work with the Centre. Over 60 people attended and there was a diverse mix of people (as above).

As a result of attending this event, a member of the audience will become a new PhD student for the Centre in April 2017.
Year(s) Of Engagement Activity 2016
 
Description Climate Tipping Points Workshop 2016 - poster presentation (JS) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact This workshop, which was hosted by Tim Lenton (University of Exeter), followed on from the Tipping Points meeting that was hosted by Marten Scheffer and Sebastian Bathiany in Amsterdam last year (2015).

The aim of the workshop was to:

to reflect on progress in the mathematics of tipping points,
to work towards the development of some joint paper(s), and
to link up with part of the new 'CRITICS' EU network of PhD students studying critical transitions.
Year(s) Of Engagement Activity 2016
URL https://sites.google.com/site/recoverlwec/activities-and-events/climate-tipping-points-workshop-2016
 
Description Dynamics in Networks with Special Properties. Mathematical Biosciences Institute, Columbus, Ohio, USA (KTA) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact This workshop explored the current state of affairs and ways of unifying emerging mathematical techniques by focusing on a variety of special biologically motivated structures.
Year(s) Of Engagement Activity 2016
URL https://mbi.osu.edu/event/?id=896
 
Description Dynamics of Excitable Systems: Neural and cardiac cells and networks. SIAM, USA 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Krasimira Tsaneva-Atanasova - organiser of mini-symopium held at SIAM Life Science, 2018, USA.
Year(s) Of Engagement Activity 2018
 
Description European conference on Theoretical and Mathematical Biology, University of Nottingham (Poster presentation) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Poster presentation by Dr Jennifer Creaser
Year(s) Of Engagement Activity 2016
 
Description Exeter Early Career Researcher Conference - Identifying patient-specific braing dynamics markers in PTSD and CBT response. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Flash talk by Jennifer Creaser
Year(s) Of Engagement Activity 2019
 
Description Exeter Maths School lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Researchers delivered a lecture to the students of the Exeter Mathematics school as part of the Inspire Lecture series organised by the school. The lecture aimed at introducing the students to mathematical concepts (such conditional probability, mutual information) and how these are being used to advance our understanding of endocrine systems.
Year(s) Of Engagement Activity 2016
 
Description ICTALS 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Jennifer Creaser - Organising committee member for the ICTALS Conference Sept 2019
Marc Goodfellow - Hosting
Year(s) Of Engagement Activity 2019
 
Description Multi-scale mathematical models in endocrinology. ECTMB 2018, Portugal 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Mini-symposium organisers Eder Zavala and Margaritis Voliotis, at 11th European Conference on Mathematical and Theoretical Biology, Lisbon, Portugal.
Year(s) Of Engagement Activity 2018
 
Description Newton Gateway to Maths Workshop - Achieving impact in Healthcare: from mathematics to clinical support systems and devices. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Peter Ashwin - Co-organiser of Newton Gateway to Mathematics workshop, Cambridge, UK
Year(s) Of Engagement Activity 2018
 
Description Patient engagement forum 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact We have run numerous events during 2015, 2016, 2017 and 2018 involving those with lived experience of epilepsy or their carers/family members, where issues around the diagnosis of epilepsy and epilepsy surgery were discussed and ideas for the future direction of the research were explored. As a result of these events, we have established a 'Experts in Epilepsy Group (EEG)' which is led by members of the Centre.
Year(s) Of Engagement Activity 2015,2016,2017,2018
 
Description Pint of Science 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The Pint of Science Festival is a public engagement event designed to engage interested parties with the latest findings from research. In this session, Wessel Woldman presented some key results from using computer models for the purpose of diagnosing epilepsy, and demonstrated EEG recordings, using a portable device.
Year(s) Of Engagement Activity 2016,2017
URL https://pintofscience.co.uk/event/biomedical-modelling-the-latest-fashion-in-medicine
 
Description Public engagement event - C. Difficile: Patients, doctors and nurses, and researchers measuring severity of clostridium difficile disease 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Diane Fraser - co-organiser of event at Universiry of Exeter
Year(s) Of Engagement Activity 2018
 
Description Public engagement event - Hormone contraceptives and mood 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Event held at the University of Exeter
Year(s) Of Engagement Activity 2018
 
Description Public engagement workshop - 'C. difficile: patients, doctors and nurses, and researchers measuring severity of clostridium difficile disease' 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Public engagement workshop: C. difficile: patients, doctors and nurses, and researchers measuring severity of clostridium difficile disease
Year(s) Of Engagement Activity 2018
 
Description Public engagement workshop - 'Hormone Contraceptives and Mood' 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Hormone Contraceptives and Mood' public involvement event. 6 people participated. Women with experience of changes in their emotions or mood while taking hormonal contraceptives were invited to take part in this workshop, to help shape the Centre's research in this area.
Year(s) Of Engagement Activity 2018
 
Description Public engagement workshop - 'Hormone Dynamics in Pituitary and Adrenal Systems' & information video 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Patients, carers and/or patient groups
Results and Impact 8 people participated (either personally or as a family member/carer/supporter) in the 'Hormone Dynamics in Pituitary and Adrenal Systems' workshop held in Exeter in August 2017. Participants were invited to find out what mathematics can do for endocrine research, and how it can enhance current therapies. Follwoing the workshop an information video was made about our research in this area, which has had over 1.3k views to date.
Year(s) Of Engagement Activity 2017,2018
URL https://www.youtube.com/watch?v=vmiTGryyF5A&t=1s
 
Description Public engagement workshop on epilepsy surgery 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Workshop on epilepsy surgery
Year(s) Of Engagement Activity 2018
 
Description Public involvement event - Using dramatic arts to communicate how mathematics can help us explain seizures and epilepsy 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact This half day workshop brought together mathematicians, actors and members of the public to explore ideas around the development a piece of theatre which depicts what is happening in the brain during seizures. Eight people with lived experience of epilepsy took part in the workshop, and were invited to share their ideas and personal experiences to explore how this could be presented in a way that is anchored in real world experiences.
Year(s) Of Engagement Activity 2016
 
Description QBME Stand - Sidmouth Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Stand with various activities
Year(s) Of Engagement Activity 2018
 
Description Research visit to University of Auckland 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Visit by Peter Ashwin, funded by the Marsden Fund (NZ)
Year(s) Of Engagement Activity 2018
 
Description Sidmouth Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact We ran a stand at the Sidmouth Science Festival introducing the electrical rhythms of the brain through a wireless EEG set-up. During the day we had more than 30 volunteers and around 75 people visit the stand, to have the brain activity recorded or to discuss what the rhythm meant.
Year(s) Of Engagement Activity 2015,2016,2017
URL http://www.sidmouthsciencefestival.org
 
Description Simulating the Natural World - Sidmouth Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Organiser - Yolanda Hill
Year(s) Of Engagement Activity 2018
 
Description Soapbox Science 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact On Saturday 11 June, from 1-4pm, Exeter's Princesshay Square was transformed into an arena for scientific debate and public learning by the University of Exeter and the Met Office. Exeter's second Soapbox Science event follows the format of London's Hyde Park Speakers' Corner and features an all-female speaker list. Its aim is to challenge the gender stereotypes associated with Science, Technology, Engineering, Maths and Medicine (STEMM) based careers by highlighting the amazing research carried out by 12 of the many talented Women in Science.
Year(s) Of Engagement Activity 2016
URL http://www.soapboxscience.org
 
Description South West Cardiac Group meeting (SWCGM) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Bringing together those in the South West with an interest in cardiac research - Yolanda Hill.
Year(s) Of Engagement Activity 2018
 
Description Spiral waves and cardiac arrhythmias - connecting the clinic and mathematics, University of Exeter 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Co-author of one of the talks - Vadim Biktashev
Year(s) Of Engagement Activity 2018
 
Description Talk on 'Uncertainty quantification for complex systems' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Talk at the Isaac Newton Institute for Mathematical Sciences professional services staff
Year(s) Of Engagement Activity 2018
 
Description The beat goes on... how insights from mathematics and computation are helping us to understand the heartbeat. Public lecture. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Yolanda Hill and Chris Marcotte contributed. Given by Professor Richard Clayton. Supported by CPMH and British Science Association.
Year(s) Of Engagement Activity 2018
 
Description Uncertainty Quantification Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact This one-day workshop was hosted jointly by the EPSRC Centre for Predictive Modelling in Healthcare (University of Exeter) and EPSRC Centre for Mathematical Imaging in Healthcare (University of Cambridge). Over 40 delegates attended, a mixture of those working within the five EPSRC Centres for Mathematical Sciences in Healthcare, and those working in related areas.

The workshop acknowledged that the use of numerical modelling and mathematical analysis in healthcare and medicine is increasing and is starting to be used to guide treatment, and that as a consequence the importance of uncertainty quantification in this area is rising too. The workshop explored the use of uncertainty quantification in the context of the EPSRC Centres and examined the different approaches being used. Discussions took place about the implications for patients and new interventions, as well as how progress might be made.
Year(s) Of Engagement Activity 2017
 
Description Workshop on Nanoscale modelling of synaptic transmission, calcium dynamics and transduction - CRM, Italy 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Krasimira Tsaneva-Atanasova: Scientific Committee Member and main organiser of a 5-day workshop at the Centro Di Ricerca Matematica (CRM) Ennio De Giorgi, Pisa, Italy
Year(s) Of Engagement Activity 2018
 
Description Workshop on Nanoscale modelling of synaptic transmission, calcium dynamics and transduction - CRM, Italy 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Workshop held at the Centro Di Riceerca Matematica (CRM), Ennio De Giorgi, Pisa, Italy - Krasimira Tsaneva-Atanasova and Kyle Wedgwood attended as Scientific Committee Member and main organiser
Year(s) Of Engagement Activity 2018
 
Description Workshop on Transient Dynamics and Epilepsy 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact The Workshop on Transient Dynamics and Epilepsy was organised by one of the Centre's Research Fellows, Jennifer Creaser. It was a popular event and a range of mathematicians, computational neuroscientists and clinicians attended. Speakers were Mark Cook and Philippa Karoly from University of Melbourne, David Liley from Swinburn University of Technology, Adam Zeman and Jennifer Creaser from the University of Exeter. The talks were followed by a discussion on identifying mathematical challenges to studying epilepsy chaired by John Terry.
Year(s) Of Engagement Activity 2016
 
Description Workshop on neural networks: from dynamical systems to psychology 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Networks are a highly topical subject for mathematical research in dynamical systems, where new challenges are being addressed, new methodologies developed and surprising connections uncovered. This workshop discussed recent research on the mathematical and computational modelling of neural-inspired dynamic networks, and explored connections to clinical-facing research.

Speakers included: Claire Postlethwaite (University of Auckland), Lorenzo Livi (University of Exeter), Juliane Britz (University of Fribourg), and Anke Karl (University of Exeter).
Year(s) Of Engagement Activity 2017
 
Description Workshop on synchronization and oscillators with generalized coupling 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact This was an academic workshop designed to bring together academics and researchers with interests in synchronization and oscillators with generalized coupling from around the world.
Year(s) Of Engagement Activity 2016
 
Description Workshop: Spiral waves and cardiac arrhythmias - connecting the clinic and mathematics, University of Exeter 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Yolanda Hill and Chris Marcotte - funded by EPSRC CPMH. Held at Living Systems Institute, Exeter.
Year(s) Of Engagement Activity 2018