EPSRC Centre for New Mathematical Sciences Capabilities for Healthcare Technologies

Lead Research Organisation: University of Liverpool
Department Name: Mathematical Sciences

Abstract

As quality of life constantly improves, the average lifespan will continue to increase. Underlining this improvement is the vast amount of the UK government's support to NHS (£133.5 billion in year 2011/12) and the UK pharmaceutical industry's R&D large investment (4.9 billion to R&D in year 2011/12). The expectation of quality healthcare is inevitably high from all stakeholders. Fortunately recent advances in science and technology have enabled us to work towards personalised medicine and preventative care. This approach calls for a collective effort of researchers from a vast spectrum of specialised subjects.
Advances in science and engineering is often accompanied by major development of mathematical sciences, as the latter underpin all other sciences. The UoL Centre will consist of a large and multidisciplinary team of applied and pure mathematicians, and statisticians together with healthcare researchers, clinicians and industrialists, collaborating with 15 HEIs and 40 NHS trusts plus other industrial partners and including our strongest groups:
MRC Centre in Drug Safety Science, Centre for Cell imaging (CCI for live 3D and 4D imaging), Centre for Mathematical Imaging Techniques (unique in UK), Liverpool Biomedical EM unit, MRC Regenerative Medicine Hub, NIHR Health Protection Research Units, MRC Hub for Trials Methodology Research.
Several research themes are highlighted below:
Firstly, an improved understanding of the interaction dynamics of cells and tissues is crucial to developing effective future cures for cancer. Much of the current work is in 2D, with restrictive assumptions and without access to real data for modelling. We shall use the unparalleled real data of cell interactions in a 3D setting, generated at UoL's CCI. The real-life images obtained will have low contrast and noise and they will be analysed and enhanced by our imaging team through developing accurate and high resolution imaging models. The main imaging tools needed are segmentaton methods (identifying objects such as cells and tissues regions in terms of sizes, shapes and precise boundaries). We shall propose and study a class of new 3D models, using our imaging data and analysis tools, to investigate and predict the spatial-temporal dynamics.
Secondly, better models of how drugs are delivered to cells in tissues will improve personalised predictions of drug toxicity. We shall combine novel-imaging data of drug penetration into 3D experimental model systems with multi-scale mathematical models which scale-up from the level of cells to these model systems, with the ultimate aim of making better in-vitro to in-vivo predictions.
Thirdly, there exist many competing models and software for imaging processing. However, for real images that have noise and are of low contrast, few methods are robust and accurate. To improve the modelling, applied and pure mathematicians team up to consider using more sophisticated tools of hyperbolic geometry and Riemann surfaces and fractional calculus to meet the demand for accuracy, and, applied mathematicians and statisticians will team up to design better data fidelity terms to model image discrepancies.
Fourthly, resistance to current antibiotics means that previously treatable diseases are becoming deadly again. To understand and mitigate this, a better understanding is needed for how this resistance builds up across the human interaction networks and how it depends on antibiotic prescribing practices. To understand these scenarios, the mathematics competition in heterogeneous environments needs to be better understood. Our team links mathematical experts in analysing dynamical systems with experts in antimicrobial resistance and GPs to determine strategies that will mitigate or slow the development of anti-microbial resistance.
Our research themes are aligned with, and will add value to, existing and current UoL and Research Council strategic investments, activities and future plans.

Planned Impact

Our team of applied, pure mathematicians and statisticians together with healthcare researchers, clinicians and industrialists will collaborate with 15 HEIs and 40 NHS trusts plus other industrial partners. Therefore the impact on the wide community is more pronounced and immediate than a responsive mode grant.

Academic impact. To the healthcare community, the proposed work will provide an insightful understanding of personalised medicine and preventative care. To the mathematical sciences community, the proposed work will advance several new directions in mathematics and statistics that will lead to high impact publications and high profile public addresses at major conferences. We see researchers in these communities as direct beneficiaries of the Centre.

The primary means of reaching out to users is by our User Engagement Forum via a series of Knowledge Exchange activities including visitor programmes; advisory service and maths and healthcare 'clinics'; summer schools; pump priming projects and activities to engage HEIs and industries; impact and public engagement activities; joint seminar series; workshops around specific problems. Some will be run with other EPSRC centres.

Economic Impact. The UK pharmaceutical industry in 2007 contributed £8.4 billion to the UK's GDP, investing 4.3 billion to R&D which is the third-highest share of global pharmaceutical R&D. The NHS budget for the UK was £133.5 billion in 2011/12 and medicines account for 10% of the NHS budget i.e. £13.4 billion. The Centre will make major contributions to UK R&D:
(i). Aided by image technologies, understanding the progression of the disease process is important to enable the industry target relevant biological processes. (ii). Incorporation of protein/cell level dynamics into tissues is necessary and essential to predict the overall toxicity. This study will lead to treatments optimised for specific patients. The pharmaceutical industry interests in drugs with less side-effects and atified medicine. It will benefit from this Centre's new analysis tools and the UoL's MRC Centre in Drug Safety Science and MRC Regenerative Medicine Hub and Trials Hub in terms of extensive experimental data, computational simulations and scientific insights on tissues; therefore, we expect this impact to continue to be facilitated with our long-term collaborative partners and new parties to perform proof-of-principle trials.

Through existing and established connections, we would build further engagement including conversion of our results into commercial products.

Societal Impact. Cancer is due to uncontrolled growth and spread of abnormal cells. Our proposed work, aiming for better understanding of cells and tissues, is crucial to combat cancer. There were 14M new sufferers (8M deaths) with 338K in UK alone in 2012. Research impact is of massive scale.

With aging, plaque due to cholesterol, calcium, and fibrous tissue can build up in arteries and due to such, they can narrow and stiffen. Coronary angioplasty and stenting are to improve blood flow in the body's arteries and veins, with 75,000 procedures performed in England per year. Our study will optimise designs to minimise side effects. It will be conducted with clinicians. Benefit and publicity to NHS are immediate.

There is considerable concern in the society with common infectious diseases, which lead to 300M illnesses and more than 5M deaths each year worldwide with Ebola outbreak well-known and anti-microbial resistance posed as massive challenge. Finding a model for it by scaling up from small/local network information to large/global networks to understand diseases' network is of vital importance to Healthcare policy makers and service providers.

We will use these to engage the public at annual Science Festivals. We believe that these will not only raise awareness of the complexity in disease networks, but also generate interest in the community fascinated by bio-mimic system.

Organisations

Publications

10 25 50
 
Title collaboration with music composer Emily and launch of PRISM 
Description PRiSM is the RNCM Centre for Practice & Research in Science & Music PRiSM brings together a number of creative collaborations between the sciences and music. PRisM was launched the 04/10/2017 with "The Music of Proof" performance 
Type Of Art Performance (Music, Dance, Drama, etc) 
Year Produced 2017 
Impact Dr Howard music composition has been influenced by discussion with mathematicians and biologists 
URL https://www.rncm.ac.uk/research/research-centres-rncm/prism/
 
Description The project has passed its half mark, and the completed (or nearly) projects have

1. T1 Project 1 (stenting). We have found a relationship between stents' size and damage to the stents in operating conditions. This is through
constructive description of favourable and unfavourable conditions for endovascular sealing of abdominal aortic aneurysms and by our analysis tool developed at LCMH. The finding is published in Proceedings of the Royal Society and the Nature Sci Report.

2. T2 Project 1 (segmentation using partial priors). We have designed reliable minimal path-following algorithms to produce an accurate segmentation
which is much faster than the usual fully 3D models. The speed-up is from dimension reduction while the reliability is by achieving non-intersecting paths.

3. T2 Project 2 (multi-modality image co-registration). We have found new models for aligning images which are much better than the established models based on normalized gradients or mutual information.

4. T3 Working with Public Health England, we have used a mathematical model to show that antimicrobial resistance (AMR) in the infectious disease Shigella occurs due to plasmid transfer rather than co-infection. It is important for control of the disease but also for understanding this mechanism of AMR.

5. T3 Ongoing work modelling the development of AMR in cystic fibrosis patients is enabling us to develop patient-specific antibiotic treatment courses to minimise the development of AMR.

6. T3 Work on modelling influenza dynamics in the UK with an age-structured population using an MCMC model enables prediction of transmission and immunity parameters from known birth/death and migration patterns. It explains the observation of severe epidemics of A/H3N2 occurring every 6-7 years.

7. T1 Multiscale work. We have developed a multiscale mathematical modelling framework to describe the temporal and spatial dynamics of drugs in multicellular environments. The model combines information relating to the diffusion, transport and metabolism of chemical species (drugs) in 2D and 3D environments. The framework allows for the study of different transport mechanisms by varying boundary conditions on the cell membrane and for the study of the effects of cellular arrangement and physicochemical properties on the transport and penetration of drugs to simulate the problem for in vitro microtissue environments.
Exploitation Route Through our projects partners and new collaborators, as well as engagement activities. They participate the projects directly. We run regular networking events to engage national and international collaborators. Several new partners who can make use of findings have been identified and implementations on new data are in progress.
We have also organised joint workshops with other EPSRC Centres -- the next one is in April 2019 (Cambridge Turing Gateway).

The modelling framework from multiscale modelling will be used by academic researchers and industry who use micro-tissue in vitro models for testing drug efficacy and toxicity. Whilst the model was initially used to study hepatocyte spheroids, it has a wider range of applications, and we are collaborating with the Institute of Cancer Research to look at its utility in the development of cancer treatments.

The new imaging models are being applied to a wider class of data form new partners such as the Walton Center, GSK and Clatterbridge Cancer Centre.
Sectors Communities and Social Services/Policy,Digital/Communication/Information Technologies (including Software),Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

URL http://tinyurl.com/EPSRC-LCMH
 
Description The Centre grant aims to tackle healthcare challenges proposed by clinicians and industrialists by novel mathematics. Thus each started project (9 so far) has aimed for direct impact to healthcare sector. The completed projects (Theme 1 P1, Theme P1 and Theme 3 P1) have made big impacts, specifically (1) the Stenting project (Theme 1 Project 1) has produced results that have been used by clinicians to decide when the studied procedure is suitable for a patient before operations; this facilitates selection of stents and is done a rigorously way. The follow-up work is to extend the results to other stents which are not part of the original proposal. (2) the Interactive Segmentation project (Theme 2 Project 1) has also produced impressive results (as with directly industrial involvement) and the collaborating partner will start formal validation process this year to aim for adoption into products. Our work has a potential to impact future NHS diagnostic tools and platforms from which we take pride. In fact, we have started several routes of applying to specific types of segmentation problems including on-going work with IAL group (London) and the Walton Centre. (3) the influenza project (Theme 3 Project 1) is developing National scale population models of influenza sub-type transmission, infection and immunity. World Health Organization data will be used to infer key parameter values pertaining to antigenic drift rates and subtype transmission and interactions. A workshop was conducted in summer 2017 to engage with policy makers and other stakeholders. This has led to new grants and works with WHO to make use of more data to improve prediction accuracy.
First Year Of Impact 2017
Sector Digital/Communication/Information Technologies (including Software),Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology
Impact Types Societal,Economic

 
Description 3DBioNet: an integrated technological platform for 3D micro-tissues
Amount £626,046 (GBP)
Funding ID MR/R025762/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 02/2022
 
Description A Dragonfly multimodal fast imaging platform with SRRF-stream (Super-Resolution Radial Fluctuation) in the Liverpool Centre for Cell Imaging (CCI)
Amount £450,000 (GBP)
Funding ID BB/R01390X/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 05/2018 
End 04/2019
 
Description ARTFUL Statement of Need (SoN) for a mid range facility (MRF)
Amount £507,705 (GBP)
Funding ID EP/R007926/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 10/2017 
End 04/2022
 
Description Brain architecture and fuction at epilepsy diagnosis: markers of pharmacoresistance and cognitive dysfunction
Amount £645,980 (GBP)
Funding ID MR/S00355X/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Cancer Research Uk Early Detection Committee - Project Award
Amount £430,601 (GBP)
Funding ID C7738/A26196 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2018 
End 06/2021
 
Description Deep Learning Ultra Low-Frequency Heart Rate Variability from raw ECG
Amount £229,820 (GBP)
Funding ID BB/S008136/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 03/2019 
End 03/2021
 
Description Developing novel tools and technologies to assess the safety and efficacy of cell-based regenerative medicine therapies, focusing on kidney disease RenalToolBox
Amount £808,530 (GBP)
Funding ID 813839 
Organisation Marie Sklodowska-Curie Actions 
Sector Academic/University
Country Global
Start  
 
Description Development of New Low Cost Point of Care Diagnostic Technologies for Diabetic Retinopathy in China
Amount £1,150,450 (GBP)
Funding ID EP/R014094/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 02/2018 
End 01/2021
 
Description Developments of new sensor technology in collaboration with TRITEC Developments Ltd to obtain better sensor technology for the work at Alder Hey Hospital
Amount £11,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Drivers of Resistance in Uganda and Malawi: The DRUM Consortium
Amount £3,000,000 (GBP)
Funding ID MR/S004793/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description EPSRC - iCASE studentship (Smith Institute)
Amount £86,000 (GBP)
Funding ID EPSRC Voucher 17000203 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 10/2017 
End 09/2021
 
Description EPSRC First Grant Scheme (Dr T Valkonen) Centre New lecturer
Amount £168,000 (GBP)
Funding ID EP/P021298/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 03/2017 
End 03/2019
 
Description Investigating the potential of cell-based regenerative medicine therapies to ameliorate acute kidney injury and prevent progression to chronic disease
Amount £40,000 (GBP)
Funding ID JFS_IN_001_20170914 
Organisation Kidney Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2018 
End 04/2019
 
Description MRC Skills Development Fellowships
Amount £2,000,000 (GBP)
Funding ID SDF/Williamson 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 11/2017 
End 12/2020
 
Description Newton Research Collaboration Programme Award
Amount £16,660 (GBP)
Funding ID NW/CHEN 
Organisation Royal Academy of Engineering 
Sector Learned Society
Country United Kingdom
Start 03/2017 
End 03/2018
 
Description Pilot Study: Alder Hey Childrens Hospital
Amount £347,992 (GBP)
Funding ID EP/P016774/1 
Organisation University of Exeter 
Sector Academic/University
Country United Kingdom
Start 01/2017 
End 03/2019
 
Description Quantification of uncertainty within systems pharmacology to optimise personalised therapy
Amount £236,135 (GBP)
Funding ID MR/S019332/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2019 
End 12/2021
 
Description The regulation of collagen (I) homotrimer synthesis and its role in musculoskeletal dysfunction
Amount £557,967 (GBP)
Funding ID MR/R00319X/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 12/2017 
End 11/2020
 
Description Volatile organic compounds for the detection of colorectal cancer (VODECA)
Amount £440,840 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Beihang 
Organisation Beihang University
Country China 
Sector Academic/University 
PI Contribution Introduction of biomechanics skills into the biomedical research carried out at Beihang
Collaborator Contribution Funding and applications of biomedical research
Impact we are collaborating on a number of papers, none of them have been published yet.
Start Year 2018
 
Description Collaboration with Public Health England 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution Scoping work to identify research questions of direct relevance to PHE regarding influenza evolution and transmission within the UK.
Collaborator Contribution Provided time for meetings
Impact Paper submitted: "Using propensity score estimation in an adjusted study design for estimating indirect and direct vaccine effectiveness in observation studies, with application to rotavirus vaccination". Multi-disciplinary (epidemiology, mathematics, socio-demographic modelling, medicine).
Start Year 2016
 
Description Dr Hermanowicz (GlaxoSmithKline London) 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Theme 2: Professor Ke Chen and Dr Anis Theljani are working with Dr Hermanowicz (GlaxoSmithKline London) in some challenging multimodality registration problems (Optic-MRI). We have regular collaborative meetings with GSK. Our methods have been tested with GSK data and initial results are encouraging. These will form the basis for future funding applications and direct GSK funding.
Collaborator Contribution GSK have provided us with data in order to test our methods. They also attend regular collaborative meetings.
Impact Our methods have been tested with GSK data and initial results are encouraging. These will form the basis for future funding applications and direct GSK funding. No impact recorded yet.
Start Year 2018
 
Description Pump Priming - Advanced signal processing for personalised portable EEG 
Organisation University of Liverpool
Department Department of Electrical Engineering and Electronics
Country United Kingdom 
Sector Academic/University 
PI Contribution The project was a feasibility study to test the implementation of flexible signal processing algorithms to allow possible personalisation of wearable electroencephalogram (EEG) systems. The proposed approach was tested on a state-of-the-art, but relatively cheap, commercial EEG device (Neuroelectrics Enobio 8), which allows real-time data stream to external software. The project involved a collaboration with clinicians at Alder Hey hospital, to get feedback on the medical interpretation of signals, and with a UK-based manufacturer of wearable EEG, to get feedback on the software implementation from a manufacturer's point of view. Tests involving EEG measurements were carried out on the PI only.
Collaborator Contribution As above
Impact The technical outcome of the project was a preliminary software interface to stream EEG data from the commercial EEG system to an external software, which was designed in a flexible way to allow an easy customisation of signal processing algorithms. Beside the technical aspects, however, the project had an extremely positive outcome in terms of networking. The PI established a very fruitful collaboration with a team of neurologists and neurophysiologists at Alder Hey hospital, which led to follow-on research activities. This collaboration has already been successful in securing two PhD studentships, a collaborative grant (Hugh Greenwood Legacy Fund) and a Knowledge Exchange & Impact Voucher.
Start Year 2017
 
Description Pump Priming - Developments of novel imaging methods for cell collisions 
Organisation University of Sussex
Country United Kingdom 
Sector Academic/University 
PI Contribution Cell tracking is becoming increasingly important in cell biology as it provides a valuable tool for analysing experimental data and hence furthering our understanding of dynamic cellular phenomena. The advent of high-throughput, high-resolution microscopy and imaging techniques means that a wealth of large data is routinely generated in many laboratories. Due to the sheer magnitude of the data involved manual tracking is often cumbersome and the development of computer algorithms for automated cell tracking is thus highly desirable. On the other hand, real world data is noisy and unstructured. To fully automate cell tracking is challenging. A wide recognised topic arises when cells collide together (during migration). Failing to correctly categorise this event will result in false terminations of cell tracks. This not only creates inaccuracy but also the prolonged effects will negatively affect detections on other important events such as proliferation. There have been some researches trying to solve this problem, for example, Bensch and Ronneberger proposed a segmentation technique in 2015 to accurately identify cell outlines in phase contrast images. However, like many other theoretical researches, they lack of practicality and would require a number of adaptations and robust implementation in order to be effective to real world data. The proposed collaboration with LCMH is to come up with a clear, practical idea to deal with cell collisions, that can be applied to real world datasets with minimal assumptions and limitations. It is also my intention to collaborate with members of LCMH, testing and improving the cell tracking functionality of tools used by LCMH.
Collaborator Contribution As above
Impact Ongoing - no outcomes reported yet.
Start Year 2018
 
Description Pump Priming - Modelling insulin effects on cell cycle and bio-energetics 
Organisation University of Liverpool
Department School of Biological Sciences Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution This will be an interdisciplinary effort to gain greater insight into the effect of insulin on cell cycle and bioenergetics. At present, there is no understanding of how the different pathways downstream insulin control proliferation and the balance between aerobic and anaerobic energy production. We need to define a conceptual integration of the mechanisms regulating proliferation and use of energy in a wide range of cell types. We plan to achieve this with a workshop with leading biology expert (Prof. Stefano Biffo) and clinicians (Prof. Josep Roca and Dr. Michael Trenell). The novelty will be in the integration between the eIF6, mTOR and MEK pathways and their linkage to cell-cycle control, building on knowledge acquired in (1,2,3). Special focus will be given to information that can be gained from single cell data (rather than population averages) and incorporation of this information into the models. (1) Clarke et al., (2017), Cell Rep.; (2) Brina et al., (2015), Nature Communications; (3) Ankers, Basili, Pisconti, Bearon and Falciani, A systems biology approach identifies mTOR-independent and dependent relationships between insulin and the cell cycle in muscle progenitors, in prep.
Collaborator Contribution As above
Impact Ongoing - no output yet recorded.
Start Year 2018
 
Description Pump Priming - Music and mathematics interrogate brain tumour dissemination 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution AIMS - Two connected parts: (1)To use mathematics to interrogate brain tumour dissemination & thus improve chemotherapy treatment protocols. (2)To develop the collaboration between EH and the Dept. of Mathematical Sciences through an investigation of a project at an interface of maths, music & health.
Collaborator Contribution As above
Impact OUTCOMES - (1) Presentation (RB) at LCMH event, Liverpool, Sep 2017 (2) Allocation of department GTA studentship to Marianne Scott (MS) to work on cell motility (3) MSc dissertation (distinction) (MS/RB) "The Persistent Random Walk Model and its application to Glioblastoma cell migration" (4) Video presentation at PRiSM launch, Manchester, Oct 2017 (5) Poster presentation at Liverpool-Glasgow centre meeting (Marianne Scott, RB), Liverpool, Aug 2018 (6) Private premiere of 'Outlier' for solo viola (EH), London, Sep 2018 (7) R. Richards, D. Mason, R. Levy, R. Bearon & V. See, "4D imaging and analysis of multicellular tumour spheroid cell migration and invasion" Publication in preparation (RB provided revisions to final draft in Sep 2018). (8) Invitation to Oaxaca BIRS-CMO workshop, "Mathematical Challenges in the Analysis of Continuum Models for Cancer Growth, Evolution and Therapy" (RB), November 2018
Start Year 2017
 
Description Pump Priming - New Development of AI Techniques for Heart Imaging 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Cardiovascular magnetic resonance imaging (CMR) has established itself as the non-invasive gold standard for assessing cardiac function (volume and strain) for a wide range of cardiovascular diseases, and it is also widely used in the mathematical modelling communities for developing personalised medicine. However, the geometry of the heart used in mathematical modelling currently is acquired by manual delineation of CMR images, which is time-consuming, tedious and error-prone. There is an urgent need to develop a framework to automatically analyse CMR image at all time points across a cardiac cycle, derive clinical measures in real time, and feed to subsequent mathematical modelling. This will facilitate large-population studies, such as the UK Biobank (http://ukbiobank.ac.uk). Artificial intelligence (AI) algorithms, especially deep convolutional neural networks, have demonstrated great potential in a number of visual tasks including objective recognition not only in natural images, but also in CMR images [Vigneault et al, 2018; Bai et al, 2018]. This pump-priming project is planned to start on 1 Oct 2018 for 6 months. The overarching aim of this project is to obtain preliminary data for the forthcoming programme grant application. Our specific objectives are as follows. Sub-project 1: AI-based Automatic Segmentation of Ventricular Border 1. Optimise existing AI segmentation techniques for the segmentation of heart CMR data. 2. Investigate new activation/cost functions and optimisation methods for AI. 3. Evaluate the performance of the new AI tools for ventricular border segmentation with the Glasgow team. Sub-project 2: Variational approach for longitudinal strain estimation 1. Develop new regularization/cost function and optimisation method for AI based registration, and evaluate the accuracy and reliability with ground truth data provided by the Glasgow team. 2. Evaluate the performance of the new approaches on a large cohort of MI patient segmentation with the Glasgow team. The results will be presented at the SofTMech Workshop in the LHMC workshop (March 2019) and in Glasgow (June 2019), and subsequently for journal publications.
Collaborator Contribution As above
Impact Outcomes not yet reported.
Start Year 2018
 
Description Pump Priming - Transforming spatio-temporal statistical learning methods: for complex clinical datasets that contain imaging data 
Organisation City, University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution I am applying for pump priming funding to cover expenses towards preparation fora grant proposal on "Transforming spatio-temporal statistical learning methods: for complex clinical datasets that contain imaging data" to be submitted to the MRC on 14 November (MRC Methodology Research Panel). My overarching ambition is to develop a new field of data analytics - spatio-temporal statistical learning methods for imaging and functional data - to deliver a revolutionary improvement in statistical methodology and to apply them for more precise utilisation of routinely collected imaging data toward more precise, cost-effective and point-of-care management of eye diseases. Past work (the proof of concept): In the last twelve months I have lead and developed a proof-of-concept spatial statistical methodology and software development for analysis of retinal images. We did two works. First, we developed spatial model that evaluates the association between the capillary non-perfusion and survival of children with malarial retinopathy (MacCormick et al., Sci Rep 2017). Second, we developed a spatial model of shape of optic nerve head and derived a diagnostic tool for detection of glaucoma in eyes (manuscript in preparation for submission) which is an extension of our work on epilepsy (Hughes et al. SMMR 2016, Stat in Medicine 2017). Our work on capillary non-perfusion helps to understand that capillary non-perfusion is important risk factor for death outcome. Our glaucoma detection tool gives accuracy of 97% which is a dramatic increase from 84% accuracy of machine learning approaches. For example, in the future the optometrists can have an application that will tell them the probability of glaucoma and will recommend the patient to be send to a clinic. The projected number of people affected with glaucoma worldwide is estimated to reach 111.8 million in 2040; with the majority of patients in Asia and Africa. Our method will lead to better screening and to improved diagnosis of glaucoma and consequently to improved health outcome. This proof-of-concept has been an effort of a team lead by Dr Gabriela Czanner. It has involved ? Imaging specialists: Dr Bryan Williams (U of Liverpool), Dr Silvester Czanner (Manchester Metropolitan University), ? Clinicians: Rob Cheeseman and Dr Ian MacCormick, Prof Simon Harding (U of Liverpool and Royal Liverpool University Hospital), and Prof Colin Willoughby (Belfast), ? Machine learning: Dr Kun Li (Taishan Medical College, China) and Dr Yalin Zheng (U of Liverpool), ? Statisticians: Dr Gabriela Czanner (U of Liverpool), Prof Emery Brown (Harvard/MIT) and Prof Peter Diggle (CHICAS, Lancaster). The proposed activity and its novelty: I am proposing to - Prepare grant proposal and apply for grants: MRC MRP (14 November 2018) - Organise two scoping meetings in Liverpool. The aim of the scoping meetings will be to work on grant proposal, the external visitors will be asked to give a seminar. Other meetings will be facilitated via skype and email. - One visit to City University (Prof David Crabb) and one visits to Lancaster CHICAS (UK). - One visit to Prof Emery Brown and Eye and Ear Infirmary hospital (Boston, USA). Skype meetings will be scheduled with Prof Brown to discuss the details for the grant proposal. One visit of Dr Czanner will be planned to Boston, to meet his team and to set up a collaboration and data sharing with the Eye and Ear Infirmary hospital in Boston.
Collaborator Contribution As above
Impact Not reported yet.
Start Year 2018
 
Description Pump Priming - Transforming spatio-temporal statistical learning methods: for complex clinical datasets that contain imaging data 
Organisation Lancaster University
Department Centre for Health Informatics, Computing, and Statistics (CHICAS)
Country United Kingdom 
Sector Academic/University 
PI Contribution I am applying for pump priming funding to cover expenses towards preparation fora grant proposal on "Transforming spatio-temporal statistical learning methods: for complex clinical datasets that contain imaging data" to be submitted to the MRC on 14 November (MRC Methodology Research Panel). My overarching ambition is to develop a new field of data analytics - spatio-temporal statistical learning methods for imaging and functional data - to deliver a revolutionary improvement in statistical methodology and to apply them for more precise utilisation of routinely collected imaging data toward more precise, cost-effective and point-of-care management of eye diseases. Past work (the proof of concept): In the last twelve months I have lead and developed a proof-of-concept spatial statistical methodology and software development for analysis of retinal images. We did two works. First, we developed spatial model that evaluates the association between the capillary non-perfusion and survival of children with malarial retinopathy (MacCormick et al., Sci Rep 2017). Second, we developed a spatial model of shape of optic nerve head and derived a diagnostic tool for detection of glaucoma in eyes (manuscript in preparation for submission) which is an extension of our work on epilepsy (Hughes et al. SMMR 2016, Stat in Medicine 2017). Our work on capillary non-perfusion helps to understand that capillary non-perfusion is important risk factor for death outcome. Our glaucoma detection tool gives accuracy of 97% which is a dramatic increase from 84% accuracy of machine learning approaches. For example, in the future the optometrists can have an application that will tell them the probability of glaucoma and will recommend the patient to be send to a clinic. The projected number of people affected with glaucoma worldwide is estimated to reach 111.8 million in 2040; with the majority of patients in Asia and Africa. Our method will lead to better screening and to improved diagnosis of glaucoma and consequently to improved health outcome. This proof-of-concept has been an effort of a team lead by Dr Gabriela Czanner. It has involved ? Imaging specialists: Dr Bryan Williams (U of Liverpool), Dr Silvester Czanner (Manchester Metropolitan University), ? Clinicians: Rob Cheeseman and Dr Ian MacCormick, Prof Simon Harding (U of Liverpool and Royal Liverpool University Hospital), and Prof Colin Willoughby (Belfast), ? Machine learning: Dr Kun Li (Taishan Medical College, China) and Dr Yalin Zheng (U of Liverpool), ? Statisticians: Dr Gabriela Czanner (U of Liverpool), Prof Emery Brown (Harvard/MIT) and Prof Peter Diggle (CHICAS, Lancaster). The proposed activity and its novelty: I am proposing to - Prepare grant proposal and apply for grants: MRC MRP (14 November 2018) - Organise two scoping meetings in Liverpool. The aim of the scoping meetings will be to work on grant proposal, the external visitors will be asked to give a seminar. Other meetings will be facilitated via skype and email. - One visit to City University (Prof David Crabb) and one visits to Lancaster CHICAS (UK). - One visit to Prof Emery Brown and Eye and Ear Infirmary hospital (Boston, USA). Skype meetings will be scheduled with Prof Brown to discuss the details for the grant proposal. One visit of Dr Czanner will be planned to Boston, to meet his team and to set up a collaboration and data sharing with the Eye and Ear Infirmary hospital in Boston.
Collaborator Contribution As above
Impact Not reported yet.
Start Year 2018
 
Description Pump Priming - Transforming spatio-temporal statistical learning methods: for complex clinical datasets that contain imaging data 
Organisation University of Liverpool
Department Institute of Translational Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution I am applying for pump priming funding to cover expenses towards preparation fora grant proposal on "Transforming spatio-temporal statistical learning methods: for complex clinical datasets that contain imaging data" to be submitted to the MRC on 14 November (MRC Methodology Research Panel). My overarching ambition is to develop a new field of data analytics - spatio-temporal statistical learning methods for imaging and functional data - to deliver a revolutionary improvement in statistical methodology and to apply them for more precise utilisation of routinely collected imaging data toward more precise, cost-effective and point-of-care management of eye diseases. Past work (the proof of concept): In the last twelve months I have lead and developed a proof-of-concept spatial statistical methodology and software development for analysis of retinal images. We did two works. First, we developed spatial model that evaluates the association between the capillary non-perfusion and survival of children with malarial retinopathy (MacCormick et al., Sci Rep 2017). Second, we developed a spatial model of shape of optic nerve head and derived a diagnostic tool for detection of glaucoma in eyes (manuscript in preparation for submission) which is an extension of our work on epilepsy (Hughes et al. SMMR 2016, Stat in Medicine 2017). Our work on capillary non-perfusion helps to understand that capillary non-perfusion is important risk factor for death outcome. Our glaucoma detection tool gives accuracy of 97% which is a dramatic increase from 84% accuracy of machine learning approaches. For example, in the future the optometrists can have an application that will tell them the probability of glaucoma and will recommend the patient to be send to a clinic. The projected number of people affected with glaucoma worldwide is estimated to reach 111.8 million in 2040; with the majority of patients in Asia and Africa. Our method will lead to better screening and to improved diagnosis of glaucoma and consequently to improved health outcome. This proof-of-concept has been an effort of a team lead by Dr Gabriela Czanner. It has involved ? Imaging specialists: Dr Bryan Williams (U of Liverpool), Dr Silvester Czanner (Manchester Metropolitan University), ? Clinicians: Rob Cheeseman and Dr Ian MacCormick, Prof Simon Harding (U of Liverpool and Royal Liverpool University Hospital), and Prof Colin Willoughby (Belfast), ? Machine learning: Dr Kun Li (Taishan Medical College, China) and Dr Yalin Zheng (U of Liverpool), ? Statisticians: Dr Gabriela Czanner (U of Liverpool), Prof Emery Brown (Harvard/MIT) and Prof Peter Diggle (CHICAS, Lancaster). The proposed activity and its novelty: I am proposing to - Prepare grant proposal and apply for grants: MRC MRP (14 November 2018) - Organise two scoping meetings in Liverpool. The aim of the scoping meetings will be to work on grant proposal, the external visitors will be asked to give a seminar. Other meetings will be facilitated via skype and email. - One visit to City University (Prof David Crabb) and one visits to Lancaster CHICAS (UK). - One visit to Prof Emery Brown and Eye and Ear Infirmary hospital (Boston, USA). Skype meetings will be scheduled with Prof Brown to discuss the details for the grant proposal. One visit of Dr Czanner will be planned to Boston, to meet his team and to set up a collaboration and data sharing with the Eye and Ear Infirmary hospital in Boston.
Collaborator Contribution As above
Impact Not reported yet.
Start Year 2018
 
Description Quantification of uncertainty within systems pharmacology to optimise personalised therapy 
Organisation University of Liverpool
Department Institute for Risk and Uncertainty
Country United Kingdom 
Sector Academic/University 
PI Contribution Designed a research proposal and training plan for MRC Skills Development Fellowship.
Collaborator Contribution Provision of expertise and academic guidance as fellowship sponsor (Prof Scott Ferson).
Impact Outcome of this collaboration was Dr Joseph Leedale (Theme 1) successfully awarded the MRC Skills Development Fellowship.
Start Year 2018
 
Description Theme 1 (Multi-scale Modeling) Project 1 
Organisation Royal Liverpool University Hospital
Department Department of Vascular Service
Country United Kingdom 
Sector Hospitals 
PI Contribution We provided the vital mathematical modeling and analysis of the stenting problem
Collaborator Contribution Designed and Participated in the project. Helped establishing industrial links to the Centre.
Impact - 1 research paper - 1 joint workshop - 1 EPSRC industrial iCase studentship award
Start Year 2015
 
Description Theme 2 (Imaging and Data Integration) Project 1 
Organisation Mirada Medical Ltd
Country United Kingdom 
Sector Private 
PI Contribution We are providing the analysis model, mathematical techniques and software for image analysis
Collaborator Contribution Helped the design of this industrial project whcih has mathematical challenge to tackle
Impact - Draft papers being finalized - Test software almost ready for industrial validation
Start Year 2015
 
Description Theme 2: Dr. Kenneth Mangion (BHF Glasgow Cardiovascular Research Centre) and Dr. Hao Gao (University of Glasgow) 
Organisation British Heart Foundation (BHF)
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Theme 2: Dr Anis Theljani & Professor Ke Chen have ongoing work in collaboration with Dr. Kenneth Mangion (BHF Glasgow Cardiovascular Research Centre) and Dr. Hao Gao (University of Glasgow). We aim to apply registration techniques for strain estimation in cardiology. We have applied for pump-priming proposal "Development of AI-Segmentation and Registration for Heart Imaging '' from both the Liverpool centre and SofTMech. Our methods have been tested with BHF Glasgow Cardiovascular Research Centre's data and the initial results are promising.
Collaborator Contribution The partners have supplied us with data so we can test our methods.
Impact Initial results are promising - no impact recorded yet.
Start Year 2018
 
Description Theme 2: Dr. Kenneth Mangion (BHF Glasgow Cardiovascular Research Centre) and Dr. Hao Gao (University of Glasgow) 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Theme 2: Dr Anis Theljani & Professor Ke Chen have ongoing work in collaboration with Dr. Kenneth Mangion (BHF Glasgow Cardiovascular Research Centre) and Dr. Hao Gao (University of Glasgow). We aim to apply registration techniques for strain estimation in cardiology. We have applied for pump-priming proposal "Development of AI-Segmentation and Registration for Heart Imaging '' from both the Liverpool centre and SofTMech. Our methods have been tested with BHF Glasgow Cardiovascular Research Centre's data and the initial results are promising.
Collaborator Contribution The partners have supplied us with data so we can test our methods.
Impact Initial results are promising - no impact recorded yet.
Start Year 2018
 
Description Theme 2: Royal Liverpool and Broadgreen University Hospitals NHS Trust 
Organisation Royal Liverpool and Broadgreen University Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution Theme 2: Working as partners with Royal Hospital we developed a novel data efficient and accurate glaucoma detection algorithm based on optic disc deformation (MacCormick et al., accepted for a publication in PLOSONE). We used the Royal Hospital's data to find our initial results and we are now approaching several hospitals in the UK for further clinical data to further validate the algorithm and to extend it into longitudinal data.
Collaborator Contribution Expertise on glaucoma detection based on optic disc deformation and data for testing our methods.
Impact The following journal was published following work in this partnership: MacCormick IJC, Williams BM, Zheng Y, Li K, Al-Bander B, Czanner S, Cheeseman R, Willoughby CE, Brown ENB, Spaeth GL, Czanner G. Accurate, fast, data efficient and interpretable glaucoma diagnosis with automated spatial analysis of the whole cup to disc profile. PLOSONE. Accepted 6 Dec 2018.
Start Year 2018
 
Description Theme 3 Collaboration with World Health Organization 
Organisation World Health Organization (WHO)
Country Global 
Sector Public 
PI Contribution Modelling seasonal influenza incidence and evolutionary dynamics. . Participation in bi-weekly teleconference calls. This (hopefully) will also lead to engagement when we relay our findings back to WHO.
Collaborator Contribution WHO are providing up-to-date data gathered from their surveillance system. Participation in bi-weekly teleconference calls.
Impact Ongoing work
Start Year 2016
 
Description Theme 3 Collaboration with World Health Organization 
Organisation World Health Organization (WHO)
Country Global 
Sector Public 
PI Contribution Modelling seasonal influenza incidence and evolutionary dynamics. . Participation in bi-weekly teleconference calls. This (hopefully) will also lead to engagement when we relay our findings back to WHO.
Collaborator Contribution WHO are providing up-to-date data gathered from their surveillance system. Participation in bi-weekly teleconference calls.
Impact Ongoing work
Start Year 2016
 
Description Wenzhou 
Organisation Wenzhou Medical University
Country China 
Sector Academic/University 
PI Contribution Topography analysis based on techniques developed in EPSRC project
Collaborator Contribution Collection and analysis of a huge set of topography maps
Impact A number of papers linked to this projects have been produced as a result of this collaboration.
Start Year 2015
 
Description Presented at Leverhulme Research Centre Harnessing Exponential Growth workshop, University of Liverpool (September 2017) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Theme 2: Presented at Leverhulme Research Centre Harnessing Exponential Growth workshop, University of Liverpool (September 2017)
Year(s) Of Engagement Activity 2017
 
Description workshop focused on cell imaging and image analysis 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The Centre for Cell Imaging organised a 2 day workshop focused on light microscopy techniques and image analysis. 90 researchers and students attended the event mainly from Liverpool and Manchester but also from other Universities in the UK. Industrial partners were invited and the director of the Advanced Imaging Centre at the HHMI Janelia Research Campus, Teng-Leong Chew gave a keynote lecture and a comprehensive hands-on training session on Image Analysis.
Year(s) Of Engagement Activity 2017
URL https://cci.liv.ac.uk/2017_workshop.html
 
Description 7 Talks by the Liverpool Group / LCMH at SIAM Conference on Imaging Science, June 5-8, 2018, Bologna - Italy. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact 7 Talks by the Liverpool Group / LCMH at SIAM Conference on Imaging Science, June 5-8, 2018, Bologna - Italy.
Year(s) Of Engagement Activity 2018
URL https://www.siam-is18.dm.unibo.it/
 
Description Bi-Weekly PDRA Seminars 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Bi-weekly meetings between all PDRA's and Post Graduate students at the EPSRC Liverpool Centre for Mathematics in Healthcare where presentations and updates are given and feedback is received.
Year(s) Of Engagement Activity 2017,2018,2019
 
Description British Applied Mathematics Colloquium. BAMC 2017, University of Surrey, UK (April 10-12, 2017) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The talk delivered is S. Frecentese, G. Carta, L.P. Argani, A.B. Movchan, N.V. Movchan, M.L. Wall, "Bloch waves in
blood vessels with stents"
Year(s) Of Engagement Activity 2017
 
Description British Science Festival - Public engagement and outreach 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The Centre is keen to explain what we do to the public. In 2007, we took part in this Public engagement and outreach. A. Movchan and L. Argani have presented an event at the British Science Festival, Mathematical Events 2017. Brighton, 5-9 September 2017 (Friday 8 September, 16.30-17.30, A2, Asa Briggs Arts, University of Sussex), entitled ``Towards better aneurysm treatments'', which attracted a lot of interest from experts and members of the general public.
Year(s) Of Engagement Activity 2017
URL https://www.britishscienceassociation.org/british-science-festival
 
Description Centre workshop 1 - Sept 2016 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Imaging workshop where we reported our projects and findings, invited industrial partners to tell us their challenges in their work.
The networking event is well received.
Year(s) Of Engagement Activity 2016
URL http://www.tinyurl.com/EPSRC-LCMH
 
Description Centre workshop 2 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Stenting for abdominal aortic aneurysms - modeling experts met clinicians and industrial partners and new / potential collaborators.
New results are highlighted and new problems are identified.
Year(s) Of Engagement Activity 2017
URL http://www.tinyurl.com/EPSRC-LCMH
 
Description Co-supervision of PhD student 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Co-supervision of PhD student Hawre Salih by Prof Ke Chen, Dr Tuomo Valkonen and Dr Anna Pratoussevitch.
Year(s) Of Engagement Activity 2017,2018
 
Description Dr Joseph Leedale - Multiscale modelling of drug transport in systems pharmacology Seminar at the QSP UK Exchange Workshop, Reading 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Dr Joseph Leedale gave a talk entitled 'Multiscale modelling of drug transport in systems pharmacology' at the Quantitative Systems Pharmacology (QSP) UK Exchange Workshop, University of Reading (July 2018).
Year(s) Of Engagement Activity 2018
 
Description Dr Joseph Leedale displayed his poster 'Multiscale modelling of drug transport in systems pharmacology' at STEM for BRITAIN 2018, House of Commons. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Dr Joseph Leedale displayed his poster 'Multiscale modelling of drug transport in systems pharmacology' at STEM for BRITAIN 2018, House of Commons, Westminster, London (March 2018).
Year(s) Of Engagement Activity 2018
 
Description European Symposium on Vascular Biomaterials - ESVB 2017, Strasbourg, France (October 12-14, 2017) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact L.P. Argani, F. Torella, R.K. Fisher, R.G. McWilliams, M.L. Wall, A.B. Movchan, "Modelling of
deformation and dynamic response of abdominal aortic aneurysms treated by endovascular
sealing"
- L.P. Argani was selected among the 8 finalist for the Young Researcher Prize
Year(s) Of Engagement Activity 2017
 
Description FLUENCE workshop in Nijmegen 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This was a workshop to intrude a group of UK scientists to the use of the FELIX free electron lasers in Nijmegen
Year(s) Of Engagement Activity 2018
 
Description Five Centres Mathematics for Healthcare Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact FIVE EPSRC Maths-Healthcare Centres (Cambridge, Exeter, Imperial, Liverpool and SofTMech) gathered together from the 19th to the 21st September 2018 at the University of Glasgow to exchange success stories and share experiences, and more importantly to consider future funding. Kings College London, UCLouvain, the University of Lancaster, Terumo Aortic and The Sick Children's Hospital in Glasgow were also represented by speakers who had been invited by one of the centres. Each of the Centres had recently completed their Mid-Term Review. Two portfolio Managers from the EPSRC, who fund the five centres attended, giving the centres the perspective of the EPSRC, as they discussed the way forward.

This was the first of two workshops. The centres gave an overview of the work at their centre, in particular highlighting new and exciting work where collaboration with other UK expertise would form a stronger funding application. In addition to the external speakers each centre had a number of internal speakers who gave presentations on their research and how it fitted in with the overall theme of their Maths and Healthcare Centre.
Year(s) Of Engagement Activity 2018
URL http://www.softmech.org/events/headline_593316_en.html
 
Description Infectious Disease Modelling Summer School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Two week-long workshop held in Japan for public health practitioners and graduate students to develop a practical understanding of infectious disease modelling. Read was delivered sessions on seasonal influenza epidemiology and modelling epidemics in structured populations. Audience was drawn from Japan as well as other countries in the region (including South Korea, China, Indonesia, Philippines).
Year(s) Of Engagement Activity 2016
URL https://sites.google.com/site/modelinfection/home/shortcourse3
 
Description Interdisciplinary EPSRC Workshop "Elastic deformation and dynamic response of aneurysm repairs: modelling and applications" (Liverpool, UK, February 2017) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This interdisciplinary workshop attracted leading scientists, applied mathematicians and medical practitioners from the UK, USA, Netherlands, Italy. The workshop has focused on the practical and theoretical aspects of abdominal aortic aneurysms, and in particular EVAS treatment. The Liverpool group and their partners have contributed six presentations to this event: S. Frecentese, "Modelling of waves in stented blood vessels"
L.P. Argani, "Modelling of deformation and dynamic response of abdominal aneurysm
sealing"
F. Torella, "Introduction to AAA, EVAR and EVAS"
R.K. Fisher, "Modes and mechanisms of failure of EVAR/EVAS"
R.G. McWilliams, "Methods of imaging surveillance after EVAS/EVAR"
M.L. Wall, "Aneurysm rupture - theoretical and practical challenges"
Year(s) Of Engagement Activity 2017
 
Description Invited Seminar, EPSRC Centre for Predictive Modelling in Healthcare, University of Exeter. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited seminar at the EPSRC Centre for Predictive Modelling in Healthcare, University of Exeter. Useful discussions during and afterwards which have highlighted important new techniques that could help optimise my current approach.
Year(s) Of Engagement Activity 2017
 
Description Invited Talk at "Efficient Operator Splitting Techniques for Complex System and Large Scale Data Analysis 2019", Sanya International Forum, Jan 14-18 2019. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Theme 2: Invited Talk at "Efficient Operator Splitting Techniques for Complex System and Large Scale Data Analysis 2019", Sanya International Forum, Jan 14-18 2019.
Year(s) Of Engagement Activity 2019
 
Description Invited Talk at "ICCM Consortium conference on Computational and Applied Mathematics", Nanjing, Dec 10-14, 2018. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Professor Ke Chen - Theme 2: Invited Talk at "ICCM Consortium conference on Computational and Applied Mathematics", Nanjing, Dec 10-14, 2018.
Year(s) Of Engagement Activity 2018
 
Description Invited Talk at "International Conference on Scientific Computing", CUHK, Hong Kong, 5-8 December, 2018. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Theme 2: Professor Ke Chen. Invited Talk at "International Conference on Scientific Computing", CUHK, Hong Kong, 5-8 December, 2018.
Year(s) Of Engagement Activity 2018
 
Description Invited Talk at "International Workshop On Image Processing and Inverse Problems", Beijing, April 21-24, 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited Talk at "International Workshop On Image Processing and Inverse Problems", Beijing, April 21-24, 2018
Year(s) Of Engagement Activity 2018
URL https://www.csrc.ac.cn/en/event/workshop/2017-12-27/78.html
 
Description Invited Talk at the "Workshop on Mathematical Theory and Methods in Image Processing", Hunan Normal University, Changsha, Apr 24-28, 2018. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Theme 2: Professor Ke Chen - Invited Talk at the "Workshop on Mathematical Theory and Methods in Image Processing", Hunan Normal University, Changsha, Apr 24-28, 2018.
Year(s) Of Engagement Activity 2018
 
Description Invited presentation at the International Conference for the In Vitro Toxicology Society, London. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation at the International Conference for the In Vitro Toxicology Society, London. Useful discussions afterwards with potential future collaborators. Also, a number of followup meetings planned to develop future collaborations.
Year(s) Of Engagement Activity 2017
 
Description Invited seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact 2nd Feb 2019 "Recent advances in the application of infrared techniques to the study of cancer." Physics Dept. University of Sheffield
Year(s) Of Engagement Activity 2019
 
Description Invited talk - Recent advances in joint models for multivariate longitudinal data and event-times with application to cancer - INSERM, Bordeaux, France. (January 2019) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Theme 2: Invited talk - Recent advances in joint models for multivariate longitudinal data and event-times with application to cancer. Recent advances in joint models for cancer and the new statistical challenge of immunotherapy clinical studies. INSERM, Bordeaux, France. (January 2019)
Year(s) Of Engagement Activity 2019
 
Description Invited talk. Use statistics to build further confidence in your research - University of Liverpool April 2018. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Theme 2: Invited talk. Use statistics to build further confidence in your research. An event which was part of 'How to enhance the impact of your research' series, under Athena SWAN Be Inspired banner to try to promote the involvement of women in research, University of Liverpool April 2018.
Year(s) Of Engagement Activity 2018
 
Description Invited talk. What can statistics do for the understanding of ophthalmic diseases? From measurement errors to inference and discrimination using complex datasets that contain images. (23 and 24 Apr 2018) Royal Society Science (London) (UK) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Theme 2: Invited talk. What can statistics do for the understanding of ophthalmic diseases? From measurement errors to inference and discrimination using complex datasets that contain images. (23 and 24 Apr 2018) Royal Society Science+ meeting. The transformative potential of data and image analysis for eye care. (London) (UK)
Year(s) Of Engagement Activity 2018
 
Description Invited talk: Evaluating the efficacy of longitudinal biomarker for clinical endpoint. International Conference of the European Research Consortium for Informatics and Mathematics Working Group on Computational and methodological Statistics. University of London, (December 2017) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Theme 2: Invited talk: Evaluating the efficacy of longitudinal biomarker for clinical endpoint. International Conference of the European Research Consortium for Informatics and Mathematics Working Group on Computational and methodological Statistics, Special topic: Statistical Evaluation of Medical Diagnostic Tests. University of London, (December 2017)
Year(s) Of Engagement Activity 2017
 
Description Invited talk: Evaluating the time dependent efficacy of a longitudinal biomarker for clinical endpoint. EBio2018, III Portuguese-Galician Meeting of Biometry. Aveiro, Portugal. (June 2018) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited talk: Evaluating the time dependent efficacy of a longitudinal biomarker for clinical endpoint. EBio2018, III Portuguese-Galician Meeting of Biometry. Aveiro, Portugal. (June 2018)
Year(s) Of Engagement Activity 2018
 
Description Invited talk: ISPED-Bordeaux School of Public Health & INSERM,University of Bordeaux 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The event is on specific topic to discuss recent advances in joint models for cancer and the new statistical challenge of immunotherapy clinical studies. The audience was interdisciplinary, and sparked many questions and discussions afterwards, and later through e-mail showing an increased interest in the topic I presented.
Year(s) Of Engagement Activity 2019
URL http://www.canceropole-gso.org/page/manifestations/journees-du-club-smac/642-recent-advances-in-join...
 
Description Invited visit to present work at Unilever 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Invited visit to present work at Unilever. Useful discussions that has helped align my work with more relevant industrial impact. Discussions ongoing regarding development of future collaborations and shared grant applications.
Year(s) Of Engagement Activity 2017
 
Description Liverpool - Glasgow Healthcare Modelling Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Date: Thursday 30th August 2018
Time: 12:00 -17:30
Venue: Stephenson Institute for Renewable Energy (SIRE) Seminar Room, Chadwick Building

This is the 2nd Joint meeting of two EPSRC Maths Healthcare Modelling Centres (Glasgow University and The University of Liverpool).

It will showcase works from both centres with presentations and posters from Academics, PDRA's and PHD's from both Universities highlighting new results and emerging healthcare challenges.

The main purpose of the networking workshop is to promote and facilitate new research collaborations between the TWO Universities. Pump-priming projects jointly funded by both Centres will be discussed and formed, growing out of the event as preperation for subsequent national and international grant applications.
Year(s) Of Engagement Activity 2018
URL https://www.liverpool.ac.uk/mathematical-sciences/research/centre-for-mathematics-in-healthcare/30-a...
 
Description Liverpool Cell Imaging annual workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The Centre for Cell Imaging organised a 2 day workshop focused on light microscopy techniques, imaging probes and image analysis. 90 researchers and students attended the event mainly from Liverpool and Manchester but also from other Universities in the UK. Industrial partners were invited and attended.The second day was a focused hands-on training on image analysis.
Year(s) Of Engagement Activity 2018
URL https://cci.liv.ac.uk/2018_workshop.html
 
Description Liverpool John Moores Univeristy - Invited Seminar - Dr Joseph Leedale 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Dr Joseph Leedale gave a seminar entitled 'Multiscale modelling of drug transport in systems pharmacology' at Liverpool John Moores Univesity. October 2018.
Year(s) Of Engagement Activity 2018
 
Description National Conference on the application of terahertz radiation to the study of cancer 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact An invited talk on "Characteristics of cancerous tissue in the THz region of the electromagnetic spectrum."
Year(s) Of Engagement Activity 2018
 
Description One day industrial research meeting in London with representatives of Vascutek/Terumo Aortic 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Industry/Business
Results and Impact The one day industrial meeting with representatives of Vascutek/Terumo Aortic has taken place in London on the 25th April 2018. The research group included Prof A. Movchan, Prof N. Movchan, Dr L. Argani, Miss S. Frecentese, Mr. M. Wall, Two research presentations have been given, and technical discussion was carried out with Dr T. Pacuka and his colleagues from R&D of Terumo Aortic. The meeting was highly productive and has delivered several research outcomes outlining directions for collaboration and for a joint research proposal.
Year(s) Of Engagement Activity 2018
 
Description Outreach activity at the Liverpool World Museum 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The Centre for Cell Imaging led an exhibition at the World Museum in Liverpool, as part of the "Meet the Scientist" scheme. The exhibit was entitled "seeing is believing". Members of the public, including children engaged in a numerous of activities around microscopy and bio-imaging.
Year(s) Of Engagement Activity 2018
URL https://www.liverpool.ac.uk/health-and-life-sciences/public-engagement/events/meet-the-scientists/
 
Description Poster - Multiscale modelling of drug transport in systems pharmacology' Won award at INCOME 2018 Conference and Hackathon 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Dr Joseph Leedale presented his poster entitled 'Multiscale modelling of drug transport in systems pharmacology' at the Integrative Pathway Modelling in Systems Biology and Systems Medicine (INCOME) 2018 Conference and Hackathon, Bernried, Lake Starnberg, Germany. (October 2018). Jospph won first prize which was 400 euros.
Year(s) Of Engagement Activity 2018
 
Description Presentation on Emergence risks associated with A(H7N9) Avian Influenza in China. Venue: USA State Department 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact A(H7N9) Avian Influenza in China workshop
Year(s) Of Engagement Activity 2017
 
Description Presented at Developments in Healthcare Imaging - Connecting with Academia, University of Cambridge, (May 2018) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Theme 2: Presented at Developments in Healthcare Imaging - Connecting with Academia, University of Cambridge, (May 2018)
Year(s) Of Engagement Activity 2018
URL https://gateway.newton.ac.uk/event/tgmw58/programme
 
Description Presented at One day joint workshop LCMH-GSK London, (July 2018) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Theme 2: Presented at One day joint workshop LCMH-GSK London, (July 2018)
Year(s) Of Engagement Activity 2018
 
Description Prof R Bearon invited speaker at workshop on 'Mathematical Challenges in the Analysis of Continuum Models for Cancer Growth, Evolution and Therapy'. CMO, Oaxaxo, Mexico 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Professor Rachel Bearon was an invited speaker at workshop on 'Mathematical Challenges in the Analysis of Continuum Models for Cancer Growth, Evolution and Therapy'. CMO, Oaxaxo, Mexico. (November 2018).
Year(s) Of Engagement Activity 2018
 
Description Research Discussion events with the vascular surgery group at the Royal Liverpool Hospital 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact The puprose of the research discussion events was to discuss the outcomes of the mathematical model in the context patient specific geometries and shapes of aneurysms. The meetings were very productive and technically stimulating.
Year(s) Of Engagement Activity 2017,2018,2019
 
Description Research Visit to the Walton Centre for Brain Surgery 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact The LCMH research group, Prof K.Chen, Prof A. Movchan and Ms S. Frecentese have visited the vascular department of the Walton Centre with the presentation of the mathematical modelling work to explore the avenue for the long term collaboration. Vascular surgeons of the Walton Centre are particularly interested in modelling of a complex procedure related to installation of metal stents into the selected sections of the brain vascular systems. This concerns with certain group of patients whose internal pressure of brain tissues is above the admissible level and hence some blood vessels collapse, which leads to the disruption of the blood supply of vital organs.
Year(s) Of Engagement Activity 2018,2019
 
Description Scientific oral presentation at the Dynamic Cell conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Oral presentation of Research data on 3D imaging of cell invasion.
Year(s) Of Engagement Activity 2018
URL https://bscb.org/meeting/dynamic-cell-iii/
 
Description The Vascular Societies' Annual Scientific Meeting 2017, Manchester Central, UK (November 22-24, 2017) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk delivered at the meeting was S. Frecentese, G. Carta, L.P Argani, A.B. Movchan, N.V. Movchan, M.L. Wall, "Wave
propagation and fluid-structure interaction in stented blood vessels"
Year(s) Of Engagement Activity 2017
 
Description Theme 1: Faculty of Science and Engineering Poster Day 2018 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact The annual event gives full-time second year and part-time third and fourth year postgraduate research students (PGRs) the opportunity to showcase their work to a wider academic audience and gain feedback from peers and research professionals.

Commenting on the event, FSE Director for PGR Professor David Joss, said: "Faculty Poster Days serve as a social and interdisciplinary networking event where learning, feedback and information are freely exchanged in a friendly and supportive environment. It is the perfect opportunity for like-minded people to get together and learn more about the research currently being undertaken at the University."

Five prizes were awarded at the event including prizes for each of the schools in the Faculty of Science and Engineering and an overall winner for the day.

Sara Frecentese from the School of Physical Sciences (LCMH) won for her poster on 'Waves and fluid-solid interaction in stented blood vessels'
Year(s) Of Engagement Activity 2018
URL https://news.liverpool.ac.uk/2018/03/22/faculty-of-science-and-engineering-poster-day-2018-winners/
 
Description Theme 2: Invited talk. Stereological estimation of canopy surface area. International workshop on Image Analysis and Stereology with applications on Biological and Social Sciences. Santander 11-14 September, 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Theme 2: Invited talk. Stereological estimation of canopy surface area. International workshop on Image Analysis and Stereology with applications on Biological and Social Sciences. Santander 11-14 September, 2018
Year(s) Of Engagement Activity 2018
 
Description Workshop 4 (T3) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact A workshop is being planned for summer 2017 to engage with policy makers and other stakeholders.
The subject of AMR modeling and influenza modeling is a major healthcare topic that is studied at the Liverpool Centre.
Year(s) Of Engagement Activity 2017
URL http://www.tinyurl.com/EPSRC-LCMH
 
Description workshop 3 (Imaging) jointly with Cambridge CMIH Centre 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This is a joint event with and held in Cambridge.
The teams from all 5 UK centres will be represented, excellent example of UK coherent research efforts in tackling imaging problems.
Year(s) Of Engagement Activity 2017
URL http://www.turing-gateway.cam.ac.uk/event/tgmw42