EPSRC Centre for Multiscale Soft Tissue Mechanics - with application to heart & cancer

Lead Research Organisation: University of Glasgow
Department Name: School of Mathematics & Statistics

Abstract

In the diagnosis and treatment of disease, clinicians base their decisions on understanding of the many factors that contribute to medical conditions, together with the particular circumstances of each patient. This is a "modelling" process, in which the patient's data are matched with an existing conceptual framework to guide selection of a treatment strategy based on experience. Now, after a long gestation, the world of in silico medicine is bringing sophisticated mathematics and computer simulation to this fundamental aspect of healthcare, adding to - and perhaps ultimately replacing - less structured approaches to disease representation.

The in silico specialisation is now maturing into a separate engineering discipline, and is establishing sophisticated mathematical frameworks, both to describe the structures and interactions of the human body itself, and to solve the complex equations that represent the evolution of any particular biological process. So far the discipline has established excellent applications, but it has been slower to succeed in the more complex area of soft tissue behaviour, particularly across wide ranges of length scales (subcellular to organ).

This EPSRC SoftMech initiative proposes to accelerate the development of multiscale soft-tissue modelling by constructing a generic mathematical multiscale framework. This will be a truly innovative step, as it will provide a common language with which all relevant materials, interactions and evolutions can be portrayed, and it will be designed from a standardised viewpoint to integrate with the totality of the work of the in silico community as a whole. In particular, it will integrate with the EPSRC MultiSim multiscale musculoskeletal simulation framework being developed by SoftMech partner Insigneo, and it will be validated in the two highest-mortality clinical areas of cardiac disease and cancer.

The mathematics we will develop will have a vocabulary that is both rich and extensible, meaning that we will equip it for the majority of the known representations required but design it with an open architecture allowing others to contribute additional formulations as the need arises. It will already include novel constructions developed during the SoftMech project itself, and we will provide many detailed examples of usage drawn from our twin validation domains. The project will be seriously collaborative as we establish a strong network of interested parties across the UK. The key elements of the planned scientific advances relate to the feedback loop of the structural adaptations that cells make in response to mechanical and chemical stimuli. A major challenge is the current lack of models that operate across multiple length scales, and it is here that we will focus our developmental activities. Over recent years we have developed mathematical descriptions of the relevant mechanical properties of soft tissues (arteries, myocardium, cancer cells), and we have access to new experimental and statistical techniques (such as atomic force microscopy, MRI, DT-MRI and model selection), meaning that the resulting tools will bring much-need facilities and will be applicable across problems, including wound healing and cancer cell proliferation.

The many detailed outputs of the work include, most importantly, the new mathematical framework, which will immediately enable all researchers to participate in fresh modelling activities. Beyond this our new methods of representation will simplify and extend the range of targets that can be modelled and, significantly, we will be devoting major effort to developing complex usage examples across cancer and cardiac domains. The tools will be ready for incorporation in commercial products, and our industrial partners plan extensions to their current systems.

The practical results of improved modelling will be a better understanding of how our bodies work, leading to new therapies for cancer and cardiac disease.

Planned Impact

Computers are increasingly being used to help doctors diagnose and treat disease, and new software is being developed to allow individual, patient-specific therapies. For this approach to be successful, two key issues need to be addressed. These are fundamental mathematical modelling to understand the biomechanical changes that occur in soft tissue in disease, and the development of techniques to deal with uncertainty in clinical measurements. SofTMech will carry out programmes of research by world-leading UK experts to give answers to these problems and, by developing detailed models of remodelling in the heart following a myocardial infarction (MI) and metastasis of breast carcinoma, provide computational examples that will enable healthcare technologists to translate the research into software to be used in clinical practice.

Heart disease is the leading killer in the world, responsible for about 30% of all deaths each year. Cancer is the second deadliest disease, and the World Health Organization projects that without immediate action, the global number of deaths from cancer will increase by nearly 80% by 2030. Together, these pose severe economic and medical challenges for the UK health care system. Consequently, SofTMech's research will have a major socioeconomic healthcare impact on the quality of life and health in the UK, and beyond, and enhance the UK's global competitiveness by addressing the most important healthcare problems. It is therefore of direct benefit to everyone in terms of improved quality of life and more efficient and cost-effective patient-specific treatment.

Our research will generate a range of new mathematical models for studying these diseases. Developing predictive quantitative models of healing processes after a heart attack and of the biomechanics of cancer invasion will facilitate translational medical research to enhance diagnosis, treatment, and prevention. By developing test- and data-based modelling, we will examine how cellular changes affect stress and strain distributions within organs, what drives functional responses within cells, and which parameters are strongly associated with adverse remodelling leading to heart failure or cancer metastasis. This fundamental research will significantly advance our understanding of disease pathogenesis, diagnosis and responses to therapy, and hence move clinical research forward. This will be of direct benefit to patients and healthcare providers. For example, we will focus on developing in-depth myocardium mechanics models, linked to important subcellular organelle remodelling, that will increase our understanding of the mechanical status of a heart with a MI and help us suggest treatments to prevent progression of this disease to terminal heart failure. As a further example, we will explain how cancer cells become softer and thus better able to spread through surrounding tissue, to provide new targets for interventional therapies.

International engineering-software companies that provide computer code to describe the behaviour of advanced materials, such as our partners Simulia (Abaqus) and Ansys, and their customers in advanced technologies worldwide will benefit from advanced mathematical models that predict the behaviour of soft materials that SofTMech will develop, by incorporating these models into their widely used commercial software packages. Major medical imaging companies including Siemens, another of our partners, will benefit from using our models to better interpret signals from e.g. magnetic resonance and ultrasound scanning devices, which will further benefit patients and their doctors.

The Centre will raise awareness of our research to new and existing groups by networking activities, increase knowledge transfer by involving new clinical/industrial partners through training events, and influence the effectiveness of public services and policy by engagement with the Turing Gateway.

Publications

10 25 50
 
Title SofTMech Cartoon 01 
Description Image created from the proceedings of the SofTMech Launch Event 2016-04-21 
Type Of Art Image 
Year Produced 2016 
Impact Used on the SofTMech website for outreach purposes. 
URL http://www.softmech.org/media/media_464690_en.png
 
Title SofTMech Cartoon 02 
Description Image created from the proceedings of the SofTMech Launch Event 2016-04-21. 
Type Of Art Image 
Year Produced 2016 
Impact Used on the SofTMech website for outreach purposes. 
URL http://www.softmech.org/media/media_464689_en.png
 
Title SofTMech Cartoon 03 
Description Image created from the proceedings of the SofTMech Launch Event 2016-04-21. 
Type Of Art Image 
Year Produced 2016 
Impact Used on the SofTMech website for outreach purposes. 
URL http://www.softmech.org/media/media_464691_en.png
 
Title SofTMech Cartoons 04 to 10 
Description Images created from the proceedings of the SofTMech Dialogue on Heart Failure 2016-04-22. 
Type Of Art Image 
Year Produced 2016 
Impact Used on the SofTMech website for outreach purposes. 
URL http://www.softmech.org/events/2016-04-22dialogueonheartfailure
 
Title Video clip from the Third Workshop on Soft Tissue Modelling in Glasgow 2017-07-07 
Description This is a short film produced during the proceedings of the Third Workshop on Soft Tissue Modelling held in Glasgow on 2017-07-07. It contains typical moments of research presentations, interviews with selected participants, free discussions during poster sessions. The clip conveys the excitement that participants feel about engaging in with the research field, comments on the significance and impact of research results, comments of future directions and aspirations. The level of presentation is non-technical. 
Type Of Art Film/Video/Animation 
Year Produced 2017 
Impact Helped promote other technical and outreach events organised by the SofTMech centre. Video available upon request. 
 
Title YouTube 
Description Our events are recorded and published in youtube: https://youtu.be/Ydo4G5VmSOo https://youtu.be/mH8CgNYvRw8 We also have updated animations of our modelling posted on YouTube since 2015 https://www.youtube.com/watch?v=JcUNUmbCJSI https://www.youtube.com/watch?v=Qko55MsoX8k https://www.youtube.com/watch?v=dAX8xnykZJM 
Type Of Art Film/Video/Animation 
Year Produced 2016 
Impact This is hard to assess. 
URL https://www.youtube.com/watch?v=JcUNUmbCJSI
 
Title YouTube video "Mathematically Modelling the Heart" by Peter Mortensen 
Description YouTube video "Mathematically Modelling the Heart" by Peter Mortensen. A brief video targeted at the General Public. 
Type Of Art Film/Video/Animation 
Year Produced 2018 
Impact 194 views on 2019-03-13 
URL https://www.youtube.com/watch?v=TE1IrqpyxGA
 
Description Work Package WP1 - Mechanical Model of the Whole Cell

WP1. Theoretical. The number of elements within the cell has now been extended to include stress fibres, the cell membrane and the nucleus, with material properties given for each element in addition to those of the F-actin cortex and soft neo-Hookean core. This has all been implemented in FEAP and specific calculations that account for the effects of the individual components on the overall response of the cell are in progress. A new postdoc has been appointed to continue this development.
A separate project, which links with WP5, has developed a growth/remodelling model for the myocardium based on the analysis of growth relative to the deformed configuration as distinct from the (unattainable) so-called virtual stress-free configuration. When specialized to the latter, the results agree with those obtained by Kuhl et al. (2010) [Göktepe S, Abilez OJ, Kuhl E. A generic approach towards finite growth with examples of athlete's heart, cardiac dilation, and cardiac wall thickening. J Mech Phys Solids, 2010;58:1661-1680]. By using the more realistic deformed configuration with its residual stress as the basis for growth, significantly different results are obtained. A substantial paper on this topic is currently in preparation and will be submitted for publication shortly.
WP1. Experimental.Within the experimental programme, we have developed a novel method to measure the viscoelastic property of a cell, and demonstrated its use as a potential "mechanical biomarker" to indicate the ability of cancer cell invasion. The results have been published (Scientific Reports, 8, 14462). With this capability, we further investigated the effect of an anti-cancer drug, trametinib, on cell mechanical properties. Trametinib is known to be a MECK kinase inhibitor. Our results revealed that trametinib treatment significantly reduce cell viscous properties but increase cell elasticity, which contribute to the decreased cell migration. Importantly, we found only a ~20 % of the drug treated population was affected mechanically by trametinib. This highlights the heterogeneous nature of tumour. The results correlate well to biological findings as trametinib is used most effectively in combination with other therapeutics. A paper on this is currently in preparation.
In another study which is associated with WP2 and WP6, we have established an AFM method for studying the interactions between cell and cell matrix. This work has already contributed to the discovery of a highly pro-invasive extracellular matrix deposition by mutant p53 tumor cells (Nature Communications, 2018, 9, 5069).
We have established several AFM techniques for measuring the mechanical properties of cells and matrix [Y.H. Chim, L. Mason, N. Rath, M.F. Olson, M. Tassieri, H. Yin. Probing the viscoelastic properties of cells by Atomic Force Microscopy: measuring the continuous frequency spectrum "in a step,". Scientific reports (2018) 8:14462.] With this capability, we have revealed how alternation of cytoskeleton by MAPK signalling pathway can reduce cell stiffness and enhance cancer cell invasiveness. These results have been published recently [D.A. Rudzka, G. Spennati, H. Yin, M.F. Olson. Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization. Journal of Cell Science (2019) 132, jcs224071.] To understand how cells interact with the extracellular matrix, we have recently established a traction force microscopy technique. This has been used to evaluate the effects of an anti-cancer drug, trametinib, on cell traction forces. These results have been correlated with the cell viscoelastic properties determined via the AFM2 method in the reference Chim et al. above, providing new, time-dependent information on cancer cell invasion. This work has been accepted as an oral presentation in the 18th International Congress on Rheology (ICR 2020). A separate project, which links with WP2 and WP6, has been initiate with collaborators in Beatson Cancer Institute to evaluate the role of hypoxia in cancer metastasis. Results so far have provided new evidence on how hypoxia affected cell mechanical properties, cell-matrix interactions and cell migration. These provide a solid basis to develop a close-to-in-vivo vascular platform for further in-depth investigations.

Work Package WP2 - Mechanobiological Models of Cell-Cell and Cell-ECM interactions

We have developed a computational code which is being used as the basis to simulate the force-based, individual-based model of cell-cell, cell-matrix and cell-blood-vessel interactions. The model was implemented to model the growth of cancer cells around a central blood vessel - the "tumour cord" or "tumour cuff". The new code was extended to include individual fibres in 3-dimensions and thus enable the explicit modelling of cell-matrix interactions.

Work on this Work Package was effectively stopped from October 2017 until January 2019 due to the fact that the PDRA working on this WP, Dr Cicely Macnamara, was on maternity leave. Work recommenced between January 2019 and October 2019, but stopped again due to a second period of maternity leave for Dr Macnamara. Nonetheless we have published a paper detailing the main results of the model in the Journal of Computational Science.

The work focused on understanding the specific mechanisms that occur in the tumour microenvironment and we have developed a 3D individual-based, force-based model which allows one to simulate the behaviour of, and spatio-temporal interactions between, cells, extracellular matrix fibres and blood vessels. Each agent (e.g. a single cell, a single fibre of the ECM) is fully realised within the model and interactions are primarily governed by mechanical forces between elements. As well as the mechanical interactions we have also developed the model to consider chemical interactions, by coupling the individual-based code to a finite element solver to model the diffusion of oxygen from blood vessels to cells. The current state of the art of the model allows us to simulate tumour growth around an arbitrary blood-vessel network or along the striations of fibrous tissue.

Other recent work has involved the development of a mathematical framework for the metastatic spread of cancer through local invasion of the ECM (interactions with the tumour microenvironment), interactions with blood vessels (intravasation), transport through the blood vessels/circulatory system, escape through vessel walls (extravasation) and then re-growth at the secondary location. This is the first explicitly spatial model of metastatic spread and has now been published in the Bulletin of Mathematical Biology.

Interaction with WP1 (incorporating the results of the individual cell modelling) is anticipated once Dr Macnamara returns in October 2020 as is interaction with WP3 (upscaling) once we have undertaken some more intensive computational simulations of the individual-based model.
We have also undertaken a feasibility study: "Probing and modelling cell-matrix interaction and cell invasion under hypoxia" (awarded funding in February, 2019 SofTMech Feasibility Call) in collaboration with Prof McDougall and Prof Yin to use experimental data to provide key parameter values for use in the mathematical models of angiogenesis and cell-cell interactions. This involved a study of cell interactions using Prof Yin's vasculature-on-a-chip platform. This platform consists of an interconnected channel network (i.e. analogous to blood vessels) to evaluate cell trapping locations, which can be potential starting points for angiogenesis. This has involved interaction between WP1 and WP6.

Work Package WP3 - Upscaling from Cells to Tissue

3.1 Micro-meso upscaling & reduced-order modelling tools
(RA Dr Andrey Melnik, supervised by Xiaoyu Luo, Ray Ogden)

A theoretical generalized structure tensor (GST) model has been developed for which fibre dispersion has been incorporated into the coupling invariant I8 in order to provide a consistent approach to each term of the basic Holzapfel-Ogden myocardium model. This has been completed and published [1]. The theory is now being implemented numerically and will be applied to the fitting of mechanical data from experiments on myocardial tissue.
An interesting connection property between stress components for different deformations has been identified which applies, in particular, to orthotropic constitutive models (such as those used for the myocardium) that are of separable form. This can be used as a basis for deciding whether currently used models are consistent with data that have the connection property and therefore whether the models require modification. A paper dealing with this topic has been published recently [2].

3.2 Growth and remodelling - meso to macroscale

PhD student Roxanna Barry (supervised by SofTMech CIs Stewart and Hill) has completed the development of techniques for rationally upscaling one-dimensional arrays of individual rectangular cell models (from WP1) to derive new macroscale continuum models for use in WP5. We include nonlinear hyperelastic and visoelastic models for each cell, and allow the cells to deform, grow and divide. In response to forces exerted by their neighbours, cells move along a substrate, to which they bind resulting in a `Stokes-like' drag proportional to their speed. The discrete models have been solved numerically to evaluate scaling laws for the growth and proliferation of the line of cells. Using discrete-to-continuum asymptotic methods, corresponding upscaled PDEs have been derived from the discrete models. Analytical and numerical solutions for these novel, rationally-derived PDEs show excellent agreement with the discrete models. The PDEs are much quicker to solve numerically than the discrete models for large numbers of cells and provide constitutive laws for the tissue-scale continuum models used in other work packages. A paper will be submitted to PRSL A in the next few months. Simple models of active contraction of a ring of cells are being completed, and 2D layer models are under development.

References
[1] A. Melnik, X.Y. Luo and R.W. Ogden, A generalized structure tensor model for the mixed invariant I8. International Journal of Non-Linear Mechanics 107 (2018), 137-148.
[2] A. Melnik, X.Y. Luo and R.W. Ogden, A para-universal relation for orthotropic materials. Mechanics Research Communications 97 (2019), 46-51.

Work Package WP4 - Parameter Inference and Model Selection

HEART:
We have focused on parameter estimation and uncertainty quantification in two systems: the pulmonary circulation system, and the mechanical model of the left ventricle. Due to the different computational costs of the numerical solution of the dynamical equations (1-2 minutes versus 15-20 minutes), the techniques are different. For the pulmonary circulation model, we are pursuing a fully Bayesian approach, and we have successfully combined emulation with Markov chain Monte Carlo for posterior inference. Having presented preliminary results at the ICSTA conference in Lisbon in August 2019 (best student paper award), we are currently writing these results up as a journal paper. This work includes statistical hypothesis testing of several alternative physiological fluid-tissue interaction models, and a quantification of the importance of explicitly allowing for model mismatch. The PhD student working on this project won the gold medal at STEM FOR BRITAIN in Westminster on 9th March 2020 in the category "Mathematics". For the left ventricle mechanics, we are pursuing an approach based on statistical emulation. A critical step on the pathway to impact in the clinic is the integration of the left ventricle geometry into the emulator, which requires a substantial dimension reduction by several orders of magnitude. To this end, we have systematically explored various options from established multivariate statistics (like principal components analysis) and cutting edge machine learning (using deep neural networks); these results have been published in the Proceedings of ICSTA 2020 (where we won the "best paper" award). To improve the parameter estimation results, we are exploring different options to systematically integrate physiological prior knowledge from population-wide ex-vivo data into our inference framework. A related collaborative research project with GSK on cardiac amyloidosis has been accepted for publication in Frontiers Physiology. Cancer: We have developed a method for inference in a stochastic differential equation model of cell movement, which is relevant in the pursuit of a deeper understanding of the processes underlying metastasis. Our method is a combination of approximate Bayesian computation and Gaussian process interpolation.
We have applied our method to a parameter estimation competition Cside:https://www.gla.ac.uk/schools/mathematicsstatistics/events/conferences/cside2018/) and won the first prize in the categpry "stochastic differential equations". We have also carried out methodologial research on inference in stochastic differential equations relevant to modelling cell movement and metastasis; this work has been published in Physical Review E.

Work Package WP5 - Multiscale Heart Modelling and Myocardial Infarction

5.1 Using a coupled dynamic model of LV and mitral valve, we showed that realistic chordae structure has a big impact on the MV function in pathological conditions, e.g. mitral valve regurgitation and atrial fibrillation. However, we also demonstrated that a simplified 1-D fibre model based on realistic geometry can be almost as good as 3-D fibre representation.
5.2 Using a theoretical approach, we identified a family of relations that connect stress components under different deformations, which we call para-universal relations. These relations hold for any orthotropic material whose response function is additive.
5.3 In collaboration with GSK and the National Amyloidosis Centre, we carried out research on cardiac amyloidosis. Our work demonstrated that biomechanical models have potential prognostic utility in this patient group. Our predictions agree with clinical assessments in a double-blind test in six out of the seven sample cases studied.
5.4 We have employed a monodomain model of coupled myocyte-fibroblast atrial tissue, and performed direct numerical simulations in order to investigate the essential characteristics of action potential (AP) propagation, namely the conduction velocity, the maximal AP voltage amplitude as well as break-up and decay of AP as function of size of the fibrotic region and the density of fibroblasts. While a small increase of fibroblast density can speed-up electrical propagation, both the conduction velocity and the AP amplitude ultimately decrease with the increase of fibroblast density until propagation is eventually blocked. The critical density decreases with increase of the size of the fibrotic region. To explain and interpret these results we have also analysed asymptotically reduced models of the AP front and of the AP resting state which agree to about 16% with the direct numerical simulations.
5.5 No two cardiac myocytes are ever same. By comparing the two calibrated populations (control and drug) we are able to quantify the differences between cells that respond differently to the same amount of the drug. We have developed a software pipeline that provides large-size ensembles of numerical myocyte models calibrated to reproduce closely distributions of biomarker values measured in experiments with several hundred wet cells. By comparing different calibrated populations, for example control and with pharmaceutical intervention, we are able to quantify the differences between cells that respond differently to the same amount of the drug.
5.6 By using realistic myofiber structure acquired by ex vivo high-resolution magnetic resonance imaging, we studied the effects of different myofibre approximations on ventricular pump function, we further related cross-fibre active contraction to the dispersed myofibre structure using a structural tensor framework.
5.7 In collaboration with the NPU ChinaHeart team, we studied how different strain energy functions of mitral valve affect valvular dynamics under fluid-structure interaction, and the constitutive law was identified which can fit the experimental data well and predict MV dynamics closer to clinical measurements. We further experimentally tested mechanical properties of porcine mitral valve leaflets at different location, different types of chordae, and papillary muscles, including bi-axial and uni-axial experiments. We found that material properties are very heterogeneous. Together with microstructural analysis (collagen architecture, cell morphology, etc), it will provide enriched data for more realistic MV model development.
5.8 We have developed a LV geometry reconstruction framework for longitudinal study of shape changes in MI patients purely using in vivo magnetic resonance imaging. It has been successfully applied to 16 MI patients with 4 follow-up scans. Apparent growth tensor can be estimated which is essential for developing and validating models of cardiac functional and structural adaption and remodelling after myocardial infarction.
5.9 We have completed and are testing a computational 1D structured-tree model of the coronary arterial and venous circulation, in which the vessels within the myocardium are subject to time-dependent compressive stresses as the wall contracts and expands during each heartbeat. Simultaneously, the blood vessels external to the wall are subject to the pressure generated by respiration. The geometry of the vessels is derived from data for a porcine heart supplied by Dr Jack Lee (King's College, London) supplemented with published data. The regions of the heart wall perfused by each terminal large artery have been determined using optimal transport theory, anticipating future research to couple the coronary circulation with the models of the beating heart.

Work Package WP6 Multiscale Solid Tumour Modelling

The primary focus of this WP is the multiscale modelling of blood flow and cell-tissue interactions in the context of metastatic tumour spread. Whilst our main efforts have been targeted towards breast carcinoma, we have also recently extended the remit to examine prostate cancer. The modelling is informed throughout by measured vessel and cell data obtained from collaborative laboratories and literature studies.
At the core of WP6 is the development of a numerical Perfusion-Tissue-Interactions platform (numPTI) comprising a novel lattice-free adaptive flow model of angiogenesis coupled to both an underlying in situ healthy vasculature and a cellular-scale tissue model, as discussed in WP2. In addition, the model needs to be capable of allowing tumour fragments (metastases) and microbubbles to infiltrate the feeder capillary network and be tracked as they flow through the capillary bed and tumour vasculature. By tracking microbubble infusions through beds at different angiogenic states, we hope to develop a new biomarker for cancer staging and estimating the efficacy of various treatment protocols.

Work has continued on the design and coding of a number of important perfusion and biological mechanisms related to angiogenesis, metastatic spread, and drug delivery - ab initio growth of healthy prostate vasculature, tracking of tumour fragments and microbubbles, therapeutic transport from vasculature to tissue, adaptive capillary mechanisms, tumour-capillary interactions, inter alia - all linked to one another through numPTI and visualised using our state of the art graphical user interface.

6.1 Our novel particle transport model has been extended to track diagnostic microbubbles as they flow through capillary beds and artificial contrast-enhanced ultrasound images have been produced through collaborative work with colleagues in IB3 at Heriot-Watt University under both continuous infusion and bolus injection conditions. Work is underway to produce distributions of wash-in, wash-out, and residency time distributions at a range of angiogenesis stages and tumour locations. In addition, we plan to use machine learning techniques to help us derive biomarker information through the interrogation of thousands of in silico contrast-enhanced ultrasound images produced by the model.

6.2 We have developed a new capillary tree growth algorithm based upon Murray's Law that we will be able to use for studying tumour initiation, growth and treatment within the prostate. We have implemented perfusion in these vascular trees, corresponding to those seen in vivo in the prostate, and are now able to track the evolution of microbubbles within them;

6.3 Prof McDougall and Prof Chaplain met with Prof Yin (Glasgow) and Drs Zanivan, Carlin, and Norman (Beatson Institute) to discuss how best to use experimental data to provide key parameter values for use in the mathematical models of angiogenesis and cell-cell interactions. A feasibility study was conceived that involved a study of cell interactions using Prof Yin's vasculature-on-a-chip platform. This platform consists of an interconnected channel network (i.e. analogous to blood vessels) to evaluate cell trapping locations, which can be potential starting points for angiogenesis.

6.4 A new PhD student (Ms Gabriela Ong) has taken up a position with the team and began her training in September 2019.

Work Package WP7 - Outreach and User Engagement

WP7.1: SofTMech people
a) Changes to committee membership since last report
Prof Matt Dalby has taken over as SofTMech CI from Prof Mike Olson, (who left to join Ryerson University), and will serve as the Beatson representative on the engagement committee. Student reps are Jay Mackenzie, on engagement committee, & Giulia Pederzani on outreach committee.

WP7.2: SofTMech ESPRC Mid Term Review: 15th and 16th May 2018
a) SofTMech's mid-term review was held in May 2018. The review is a condition of funding for all EPSRC Healthcare centres. The engagement & outreach committees produced relevant sections, impact and engagement of the mid-term review report and review visit. The EPSRC approved external panel was very positive about the centre and its research progress; confident about the centres impact and "particularly impressed with the industrial collaboration andefforts of the centre to create and highlight new collaborations".

WP7.3: Research Grant applications: since January 2018
? To support the long-term growth of the academic disciplines, that constitute SofTMech, and to ensure the centre's continuity, post the initial award period, SofTMech have pursued a number of funding opportunities. Since January 2018 applications that build on SofTMech research have resulted in ~£3.7m of new research awards see below.

a) EPSRC Growth and Remodelling in the Porcine Heart - Pushing Mathematics through experiments. Awarded £394k. EP/S014284/1 PI Luo

b) EPSRC Predicting the long term outcome of Percutaneous Mitral Valve Repair with MitcClip NT. Not funded £401k EP/S-19529/1

c) PI X Luo EP/S030875/1: EPSRC Centre for Multiscale soft tissue mechanics with MIT and POLIMI. £1.6m awarded. Through developing this grant we have strengthened & developed collaborative links: (Columbia University; Massachusetts Institute of Technology (MIT); Politecnico Di Milano (POLIMI) and University of California.

d) PI Luo EPSRC Advanced Fellowship: A whole-heart model of multiscale soft tissue mechanics and fluid structure interaction for clinical applications (Whole-Heart-FSI). £1.3m awarded. . In addition PI D Husmeier developed and submitted application for EPSRC funded Hub for Mathematical Sciences in Healthcare. The application was shortlisted for interview 11th February 2020 pending decision.

WP7.4: Centre for Doctoral Training (CDT) activity since January 2018
a) SofTMech Centre for Doctoral Training (CDT), in Soft Tissue Mechanics and Physiological Fluid-Structure Interactions was developed as part of a University of Glasgow internal CDT competition. Although the University did not select the CDT for external submission the preparation work has strengthened the centres external networks. Specifically:
(i) Terumo Aortic, formerly Vascutek, a leader in the aortic implant market have committed _£41k, (£38,339 50% stipend and fees + £2.5k (travel and consumables) to fund a PhD Studentship in support of SofTMech EPSRC international Centre to Centre application, EP/S030875/-, which was subsequently awarded. The University of Glasgow have provided 50% matched funding to cover stipend and fees. (ii) NHS Research Scotland and Scottish Health Innovations Ltd have committed to promote and facilitate links between SofTMech and clinicians.
b) lifETIME: EPSRC CDT in Engineered Tissues for Discovery, Industry and Medicine was funded by EPSRC. Prof Matt Dalby is a Director in this CDT with SofTMech's Prof X Luo and Prof N Hill as members of the centre's Interdisciplinary skills group.

WP7.5: Other Awards
a) Knowledge Exchange Associate (KEA): Previously reported that following a successful application, to the University of Glasgow, SofTMech was awarded funding to employ 0.5FTE KEA. The KEA, Caroline Hogarth, started on 1st April 2018. Her role to develop strong external networks and new industrial and collaborative Knowledge Exchange opportunities and to help develop links between SofTMech and Biomedical Engineering groups. Activities undertaken to date include organising & promoting the following (i) Modelling & Experiments in Drug Delivery Systems (MEDDS), workshop with PI Sean Mcginty. (ii) May 2019 Stakeholder engagement event & (iii) Dialogue with Clinicians on Retinal Haemorrhage. (iv) Business engagement for EPSRC CDT lifetime. In addition (i) Developed Industry club model with the Lifetime CDT, and is monitoring the success to see if the model can be deployed wider within SofTMech; (ii) contacting SofTMech investigators to explore potential for using their models as medical devices.
b) STEM for Britain 2018: SofTMech PhD student Louise Mason, (supervised by Huabing Yin and Ray Ogden), was awarded the Gold Medal for Engineering at the prestigious STEM for Britain event, held in UK Parliament in March 2018. Her poster was entitled `Investigating the viscoelastic properties of complex materials and cells to study cancer migration'.
c) Royal Society-Newton Mobility Grant. Prof Zishun Liu, (Xi'an Jiaotong University), and Prof Xiaoyu Luo, (University of Glasgow), awarded £12,000 over 2 years. (1st April 2018-30th March 2020). For travel to enable project: "Towards the next generation stenting- The evaluation and study on mechanics behaviour of novel shape memory polymer stent". IEC\NSGC\170202.

WP7.6: Events organised since January 2018
a) Five EPSRC Maths-Healthcare Centres Meeting. 19th-21st September 2018: FIVE EPSRC Maths-Healthcare Centres (Cambridge, Exeter, Imperial, Liverpool and SofTMech), met, (in Glasgow), to share experiences and to explore joint future funding opportunities. As a follow up the Liverpool, Cambridge and SofTMech Centres are outlining an EPSRC programme grant proposal based around physiologically-based image analysis.

b) First joint SofTMech Liverpool CMH Healthcare meeting. First meeting held between these centres. Aim to improve understanding of each others work and explore opportunities for collaborative grants and possible PhD student exchanges. 2nd Joint meeting 30th Aug 2018.

c) Multiscale Hard and Soft tissue Modelling workshop. 18th-20th June 2018. A joint SoftMech and MultiSim workshop on multi-scale hard and soft tissue modelling.

d) SIG Event on Fluid Mechanics of the Eye: 26- 27th March 2019. Event brought together a group of modellers to work on problems related to the fluid mechanics of the eye. It was funded by EPSRC UK Fluid Network with additional support from SofTMech.

e) Dialogue with Clinicians on Retinal Haemorrhage. 31st Jan 2019. Event brought together expert clinicians and modellers to discuss challenges in quantifying the onset and severity of retinal haemorrhage. The aim to provide the first steps toward a rational prediction of bleeding in the retinal circulation, to provide a robust and quantitative model for retinal haemorrhage to aid clinicians in interpreting evidence placed before them. It was funded by EP/P024270/1 with additional support from SofTMech.
f) NHS Medical Device Unit NHS Greater Glasgow Medical Devices: is a Medical Device Unit at the NHS who are talking with COSE to co-locate on campus; SofTMech is represented by Peter Stewart who has attended a workshop on 4th December 2018.
g) 4th Tissue Workshop: 5th-9th June 2019 The workshop engaged both modellers and clinicians and reviewed the progress of "state of the art" soft tissue modelling and provided a research forum on the challenges in the area.
h) SofTMech stakeholder event, 8th May 2019. This event produced opportunities to build on SofTMech research and created translational research opportunities and the identification of common research interests that would form the basis future grant applications.
i) Public Patient Participation Day: organised by the SofTMech Outreach committee was held on the 20th May 2020, The day will gave patients an insight into Mathematical Research in Healthcare and how it might in the future improve their treatment.
j) Turing Gateway to Mathematics Meeting, Achieving Impact in Healthcare: From Mathematics to Clinical Support Systems and Devices. 10th & 11th April 2019, Cambridge. This has been re-branded to Newton Gateway of Mathematics. This joint workshop of the five Centres focused on translating mathematical research into technological advances, as well as outreach and linkage with clinicians and end-user companies.

k) International Centre for Mathematics Applied to Life Sciences (CMALS): The workshop, 19th March 19, a one day symposium where the state of the art and future perspectives concerning mathematical modelling in bio-mechanics will be discussed.

l) STEM for Britain 2019: Giulia Pederzani was selected to display her poster at the House of Commons on Wed 13th March 19 on the Mathematical Sciences session.

WP7.8: SofTMech Funding: Feasibility and New Collaborations
a) Feasibility Fund: SofTMech investigators have access to feasibility funding to support external collaborations, that make use of SofTMech research outcomes, and generate new ideas that lead to new projects and new grants. Since SofTMech's launch these funds have been used to support 23 projects. External collaborators in these projects include Bordeaux University Hospital; Cairn Research Ltd; Golden Jubilee Nation Hospital; Strathclyde University; University of Ireland Galway; University of Pittsburgh; Swedish Defense Research Agency; Newcastle university and Cardiff University. See Appendix 1.

b) New Collaboration Fund: SofTMech investigators have access to funding to support the development of new collaborations. Since SofTMech's launch these funds have been used to support projects with Department of Mathematical Sciences (DISMA), Politecnico di Torino and Texas A&M University. See Appendix 2.

WP7.9: Communication channels & mechanisms
a) Software Dissemination Policy prepared, by Simetiv, and under review. This policy covers how SofTMech use web-based file hosting services such as GitHub (or GitLab) and Zenodo.

b) Website: (i) has been developed to facilitate improved engagement and compliance with GDPR

c) Newsletter: is issued quarterly to all those who have registered as SofTMech members.
Exploitation Route We shall publish all our findings in top international journals, make them open access, and present them at major international conferences and in our own soft tissue workshops, which will be held annually.

We shall enhance the uptake of our findings through our Dialogue events with clinicians and industries, and through industrial PhD studentships co-funded with industries, and through PDRA research funded by GlaxoSmithKline (GSK).

We shall organize and participate in public engagement events to make people aware of our findings. All of our activities will be highlighted in our e-news, uploaded to our website, and circulated to our members.

Having established the mathematical framework for growth and remodelling, we are developing mathematical and statistical techniques to translate the results of, e.g. our heart modelling post myocardial infarction, to clinical use.
Sectors Education,Healthcare

URL http://www.softmech.org/funding/headline_629573_en.html
 
Description The aim of the centre is to enhance the quality of life and health in the UK, and beyond, and enhance the UK's global competiveness by addressing the most important healthcare problems Heart disease, the leading killer in the world, and cancer the second deadliest disease. Our research will generate a range of new mathematical models for studying these diseases. This fundamental research will significantly advance our understanding of disease pathogenesis, diagnosis and responses to therapy, and hence move clinical research forward. The Centre started on 1st April 2016 at March 2018, researcher had produced over 80+ high-quality journal publications on model development, parameter inference, clinical applications and experiments . The delivery of planned Health/Wellbeing and Socio-Economic impacts, are not anticipated till later stages of the research programme. To date our activities to facilitate impact delivery, which are detailed under engagement, have focused on • Influencing professional practice by raising awareness of our activities to Professional practioners and seeking their views on some of the challenges associated with the research programme • Influencing public behaviour by raising awareness of soft tissue mechanics to School children and the general public. Working with Industry to understand the challenges they face and to determine how our research can help address these challenges.SofTMech's mid term review was held in May 2018. The EPSRC approved external review panel was "particularly impressed with industrial collaboration andefforts of the centre to create and highlight new collaborations". Our engagement are designed to help us better understand the challenges faced by relevant stakeholders to support our long term impact delivery agenda. To date our activities have helped develop strong relationships with industry; International and UK Universities; all EPSRC funded Healthcare centres and other organisations such as NHS Research Scotland. Our investigators have been successful in winning funding from a range of funders, (STFC; EPSRC; EU; BBSRC & the Royal Society of Edinburgh); engaging successfully with industry with key outcomes including three joint industry funded PhD studentships and two impact acceleration awards. Two highlights include our CDT success and our engagement with Glaxosmithkline (GSK) • Professor Matthew Dalby is Director of the newly funded Centre for Doctoral Training (CDT) EP/S02347X/1 with, additional SofTMech members, Prof X Luo and Prof N Hill as members of the centre's Interdisciplinary skills group. The lifETIME (Engineered Tissues for Discovery, Industry and Medicine). The CDT is a partnership between the University of Glasgow, the University of Birmingham, Aston University and CÚRAM - Science Foundation Ireland. The CDT will enable impact delivery by training innovation leaders in drug discovery and regenerative medicine through development of bioengineered humanised 3D models, microfluidics, diagnostics and sensing platforms. • SofTMech has been awarded two Impact Acceleration Awards, (i) IAA project "Tracking biomarkers of heart attacks using a fast statistical emulator based on heart modelling and in vivo MRI", The planned Socio-economic impacts include the aim of producing a useful computational toolkit for clinical research. and (ii) IAA award to support work on mathematical modelling of cardiac amyloid. This project has the potential to deliver significant Economic Impacts through developing predictive models which will enable Pharmaceutical companies to evaluate clinical trials, (testing of novel drugs), at an earlier stage in the product life cycle. SofTMech has established a new collaboration with the pharmaceutical company GlaxoSmithKline on cardiac modelling. This has led to the GSK funding of >£600k which includes support of a three-year PDRA and co-fundding of two industrial PhD studentship and two Impact Acceleration account awards Profs. Berry and Luo were also invited to give talks for the "International seminar" series at the GlaxoSmithKline's Headquarter in Stevenage on 20th Feb, 2017. This seminar helped strengthen the developing relationship with GSK. SofTMech investigators have access to feasibility funding to support external collaborations, that make use of SofTMech research outcomes, and generate new ideas that lead to new projects and new grants. Since SofTMech's launch these funds have been used to support 23 projects. External collaborators in these projects include Bordeaux University Hospital; Cairn Research Ltd; Golden Jubilee Nation Hospital; Strathclyde University; University of Ireland Galway; University of Pittsburgh; Swedish Defense Research Agency; Newcastle University and Cardiff University. In addition SofTMech investigators have access to funding to support the development of new collaborations. Since SofTMech's launch these funds have been used to support projects with Department of Mathematical Sciences (DISMA), Politecnico di Torino and Texas A&M University.
First Year Of Impact 2016
Sector Education,Healthcare
 
Description 8 Sept 2017, Professor Nicholas Hill attended EPSRC Review of KE in the Mathematical Sciences - Community Consultation Workshop, London
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Improvement of Knowledge Exchange in Mathematical sciences will facilitate collaborations between Mathematics and Industry. This will then impact on Healthcare and biotechnology products and also impact on clinical services.
 
Guideline Title 2019 ESC Guidelines for the diagnosis andmanagement of chronic coronary syndromes
Description Colin Berry cited in 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes
Geographic Reach Europe 
Policy Influence Type Citation in clinical guidelines
URL https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines/Chronic-Coronary-Syndromes
 
Description Colin Berry is a member of Regional Strategy Group for Imaging in NHS West of Scotland
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Membership of a guideline committee
 
Guideline Title Guidelines for the management of acute myocardial infarction in patients presenting with ST -segment elevation
Description Colin Berry papers cited in 2017 ESC Guidelines for the management of acute myocardial infarction
Geographic Reach Europe 
Policy Influence Type Citation in clinical guidelines
 
Description Colin Berry part of Scottish Government Women's Health Plan Committee, 2020
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
URL https://www.gov.scot/publications/protecting-scotlands-future-governments-programme-scotland-2019-20...
 
Description Colin Berry provided training at European Society of Cardiology Annual Scientific Congress, Paris August - September 2019
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
Impact Training/educational developments for postgraduates/research users.
URL https://www.escardio.org/Congresses-&-Events/ESC-Congress?gclid=Cj0KCQjw0pfzBRCOARIsANi0g0uR5vJUiCYq...
 
Description Graz Summar School
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
Impact tba
 
Description Influence on future research directions - Simitev was a member of the Engineering Prioritisation Panel Meeting 7 and 8 August 2018
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
URL https://gow.epsrc.ukri.org/NGBOViewPanel.aspx?PanelId=1-5DQRDA
 
Description Invited lecture at European Course in Minimally Invasive Neurological Therapy (ECMINT), June 2017, June 2019.
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
URL https://www.esmint.eu/ecmint
 
Description Ray Ogden taught at Graz Summar School
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
Impact Provided training in Soft tissue mechanics, including theoretical models and computation.
 
Description Simitev served as an External Examiner of a PhD Candidate at the School of Mathematics, University of Nottingham
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Training Day for Phd students and RAs organised by Professor Dirk Husmeier
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact Consolidation of Essential Background knowledge: To initiate successful interdisciplinary research projects, it is helpful for everyone to have sufficient background knowledge of the essential methodological concepts relevant to SoftMech, so as to be able to effectively collaborate and work as a research team.
 
Description 'EPSRC and SFI Centre for Doctoral Training in Engineered Tissues for Discovery, Industry and Medicine
Amount £7,013,578 (GBP)
Funding ID EP/S02347X/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 06/2019 
End 12/2027
 
Description A whole-heart model of multiscale soft tissue mechanics and fluid structure interaction for clinical applications (Whole-Heart-FSI)
Amount £1,304,759 (GBP)
Funding ID EP/S020950/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 09/2019 
End 09/2024
 
Description An Aqueous Scanning Thermal Microscope for nanoscale thermal biology
Amount £151,136 (GBP)
Funding ID BB/R021953/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 11/2018 
End 10/2019
 
Description Biomedical Catalyst Developmental Pathway Funding
Amount £2,714,383 (GBP)
Funding ID MR/S005714/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 06/2019 
End 04/2023
 
Description EPSRC ECR Capital Award
Amount £22,926 (GBP)
Funding ID 308011-01 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 09/2019 
End 03/2020
 
Description EPSRC First Grant Scheme
Amount £124,991 (GBP)
Funding ID EP/P024270/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 10/2017 
End 03/2019
 
Description EPSRC IAA project Mathematical modelling of cardiac amyloidosis and related interstitial cardiac pathologies, co funded by GSK,
Amount £25,146 (GBP)
Organisation University of Glasgow 
Department University of Glasgow Impact Acceleration Award
Sector Academic/University
Country United Kingdom
Start 12/2017 
End 06/2018
 
Description EU2020
Amount € 5,600,000 (EUR)
Funding ID Prof. Colin Berry (http://www.euroshock-study.eu/) 
Organisation European Union 
Sector Public
Country European Union (EU)
Start 01/2018 
End 12/2022
 
Description Early diagnosis and intervention of osteoporosis using nanovibrational stimulation; Professor Matt Dalby (Lead)
Amount £200,000 (GBP)
Organisation Science and Technologies Facilities Council (STFC) 
Sector Public
Country United Kingdom
Start 09/2018 
End 09/2020
 
Description Growth and Remodelling in the Porcine Heart-- Pushing Mathematics through Experiments
Amount £393,630 (GBP)
Funding ID EP/S014284/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 04/2019 
End 04/2022
 
Description Heathcare investigator-led research
Amount £387,321 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 08/2019 
End 07/2022
 
Description Industrial Funding (Consultancy)
Amount £53,986 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 05/2017 
End 04/2019
 
Description Industrial Studentship
Amount £75,480 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 10/2017 
End 09/2021
 
Description Industrial Studentship
Amount £75,480 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 10/2017 
End 09/2021
 
Description Industrial funding
Amount £468,095 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 09/2017 
End 08/2020
 
Description Institute Group Award
Amount £0 (GBP)
Funding ID A24450 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2017 
End 05/2022
 
Description Know Exchange Associate Fund
Amount £490,000 (GBP)
Funding ID KE associate 
Organisation University of Glasgow 
Department University of Glasgow Impact Acceleration Award
Sector Academic/University
Country United Kingdom
Start 04/2018 
End 03/2020
 
Description LKAS studentship
Amount £80,000 (GBP)
Organisation Glasgow Life 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2018 
End 09/2022
 
Description LKAS studentship 2 (Drug eluting stent and coronary artery disease)
Amount £80,000 (GBP)
Organisation Glasgow Life 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2018 
End 09/2020
 
Description LORD KELVIN / ADAM SMITH (LKAS) Peter Stewart, Matthew Dalby
Amount £80,000 (GBP)
Organisation University of Glasgow 
Sector Academic/University
Country United Kingdom
Start 10/2020 
End 10/2024
 
Description MEGA-FLIM: quantum technologies for megapixel time-resolved imaging and control across biological scales
Amount £1,875,030 (GBP)
Funding ID EP/T002123/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 04/2019 
End 03/2022
 
Description Royal Society of Edinburgh sabbatical research grant
Amount £62,800 (GBP)
Funding ID 62335 
Organisation Royal Society of Edinburgh (RSE) 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2019 
End 06/2020
 
Description Royal Society-Newton Mobility Grant
Amount £12,000 (GBP)
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2018 
End 03/2020
 
Description SofTMech with MIT and POLIMI (SofTMechMP)
Amount £1,599,530 (GBP)
Funding ID EP/S030875/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 06/2019 
End 06/2023
 
Description Terumo Aortic (Industry funded PhD Studentship)
Amount £41,000 (GBP)
Organisation Terumo Aortic 
Sector Private
Country United Kingdom
Start 09/2019 
End 03/2023
 
Description The lifETIME (Engineered Tissues for Discovery, Industry and Medicine), CDT, Professor Matthew Dalby (Director), is a partnership between the University of Glasgow, the University of Birmingham, Aston University and CÚRAM - Science Foundation Ireland
Amount £13,500,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 07/2019 
End 10/2028
 
Description Tracking biomarkers of heart attacks using a fast statistical emulator based on heart modelling and in vivo MRI
Amount £46,379 (GBP)
Organisation University of Glasgow 
Department University of Glasgow Impact Acceleration Award
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 03/2017
 
Title Chemotaxis chambers 
Description Various microfluidic chambers for assaying chemotaxis 
Type Of Material Technology assay or reagent 
Year Produced 2010 
Provided To Others? Yes  
Impact A number of papers; minor collaborations; and the development of even better tools 
URL https://link.springer.com/protocol/10.1007/978-1-4939-3480-5_17
 
Title Computational models and methodology 
Description We developed finite element immersed boundary methods and used these to develop new models for mitral valve, left ventricle and various coupled systems. 
Type Of Material Model of mechanisms or symptoms - human 
Provided To Others? No  
Impact Our publications are cited by a number of other research groups, and we are invited to give talks at conferences/workshops 
URL http://www.glasgowheart.org/
 
Title Immersed boundary method with finite element extension, with application to heart mechanics 
Description Built on immersed boundary method with finite element extension, fluid-structure interaction of personalized human heart modeling approach is developed, and implemented in IBAMR framework. The computational framework IBAMR is freely available to anyone through https://github.com/IBAMR/IBAMR. Heart models are shared within the centre, but not to the public. 
Type Of Material Model of mechanisms or symptoms - human 
Provided To Others? No  
Impact By employing this approach, we studied the heart function between healthy volunteers and patients with acute myocardial infarction. 
URL https://github.com/IBAMR/IBAMR
 
Title Simplified generic mathematical model of single cell cardiac action potential 
Description Mathematical model. Consists of a set of ordinary differential equations. Implemented in the form of numerical code in various computing languages - C, Fortran, Python, Matlab 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2018 
Provided To Others? Yes  
Impact Not known 
URL https://github.com/hifzhudin/CaricNobleModel
 
Title FibreGeneration-LDDMM 
Description We develop a procedure to map an ex vivo DT-MRI dataset into a porcine bi-ventricle model, all model data and algorithms are included. The companion paper is being accepted in Royal Society Open Science (http://eprints.gla.ac.uk/211485/). 
Type Of Material Computer model/algorithm 
Year Produced 2019 
Provided To Others? Yes  
Impact The Abaqus LivingHeart Team was very interested in this approach and has been trying to deploy the framework within the LivingHeart Project. 
URL https://github.com/HaoGao/FibreGeneration-LDDMM
 
Title Numerical code for simulation of electrophysiological excitation in cardiac tissues and whole hearts. 
Description This is a finite-element code capable of solving the bidomain and the monodomain equations that model the electricalphisiological excitation and propagation in 1, 2 and 3D geometries including whole heart realistic geometries. Various models for the transmembrane ionic current can be incorporated. Code ownership: Dr Hao Gao (Glasgow), Dr Radostin Simitev (Glasgow); Mr Peter Mortensen (Glasgow). 
Type Of Material Computer model/algorithm 
Year Produced 2018 
Provided To Others? No  
Impact None yet. 
 
Title Open Source software, https://github.com/IBAMR/IBAMR 
Description This open source software can be used by any research groups who are interested in modelling fluid-structure interaction and soft tissues 
Type Of Material Computer model/algorithm 
Provided To Others? No  
Impact We contributed to the develpment of this open source. 
URL https://github.com/IBAMR/IBAMR
 
Title Self-excited oscillations in a collapsible channel, with applications to retinal venous pulsation 
Description  
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
 
Title Shock wave propagation along the central retinal blood vessels 
Description  
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
 
Description Computational modelling of phagocytosis 
Organisation National Institutes of Health (NIH)
Country United States 
Sector Public 
PI Contribution We used our model of chemotaxis & adapted it to show phagocytosis
Collaborator Contribution The model confirmed wet experiments
Impact Papers; discovery of new mechanisms of chemotaxis
Start Year 2015
 
Description EPSRC SofTMech Group 
Organisation University of Glasgow
Department Mathematical Biology Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution EPSRC SofTMech Mathematical Biology and Statistics Centre
Collaborator Contribution EPSRC SofTMech Mathematical Biology and Statistics Centre and now a new award for statistical emulation (EPSRC Stats Hub).
Impact For PRIZE, study design manuscript under review
Start Year 2019
 
Description GSK (as a new collaborator) 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution SofTMech has strong engagement with GSK. GSK have joint funded two PhD studentship, funded one PDRA and provided support for two impact acceleration account applications
Collaborator Contribution At present this collaboration involves links to the School of Mathematics & Statistics and the Institute of Cardiology and Imaging at the University of Glasgow
Impact To early at this stage
Start Year 2016
 
Description GSK Partnership 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution GSK - postdoctoral and PhD Studentship to advance and exploit computational heart modelling for therapy development in patients after acute myocardial infarction
Collaborator Contribution GSK - postdoctoral and PhD Studentship, each for 3 years
Impact None as yet - posts to start in 2017
Start Year 2017
 
Description ITIS Foundation 
Organisation IT'IS Foundation
Country Switzerland 
Sector Public 
PI Contribution External co-supervision of PhD student
Collaborator Contribution Allocation of PhD student to research on aneurysm mechanobiology framework. Implementing Watton model to patient-specific geometries within a software pipeline from clinical imaging to simulation.
Impact Abstract at CMBE 2019, Tohoku, Japan. Invited lecture at intracranial stenting meeting Two draft publications.
Start Year 2017
 
Description Industrial Engagement - Neurvana Medical 
Organisation Neurvana Medical
Country United States 
Sector Private 
PI Contribution Clinically driven problem with regards predicting force that a stent needs to apply to vessel wall to mechanical treat vasospasm. Current mechanical treatment methods involve balloon angioplastly that generates higher outward forces than is necessary. The company wanted a mathematical model to support rationale of their new treatment with stents that have lower outward forces (reducing risk of damage to artery). Developed a constrained mixture model of the arterial wall to reflect its mechanics before/after vasospasm and to predict additional pressure (above blood pressure) needed to damage vascular smooth muscles to resolve vasospasm. Results consistent with (recent) clinical observations.
Collaborator Contribution Industrial company funded Dr Watton's Softmech PhD student, Giulia Pederzani, to attend an international clinical conference to present findings of research.
Impact Clinical paper (submitted). Two presentations (oral) at international clinical conferences (ABC-WIN, Val d'sere, Jan 2018; iNEW, Zurich Feb 2018). Multidisciplinary (Clinical research, Industrial company des, mathematics)
Start Year 2017
 
Description Industrial Engagement Vascutek 
Organisation Vascutek Ltd
Country United Kingdom 
Sector Private 
PI Contribution SofTMech organised an industry Dialogue which was held in November 2017. As a follow up activity members of the SofTMech team met with members of Vascutek, in January 2018, The aim of the meeting to better understand Vascutek's industrial challenges and to have more in depth discussion on areas of research expertise within the SofTMech team. A follow up conversation took place, in February 2018, to identify specific research projects of mutual interest and to explore opportunities for collaboration. Development of this relationship is ongoing. Engagement has led to company becoming a partner on recent SofTMech International centre to centre application. As part of this company have committed to 50% fund a PhD studentship. This application EP/S030875/1was successful and a £1.6m EPSRC grant awarded
Collaborator Contribution Vascutek identified specific research topics/challenges which they are interested to work on in collaboration with SofTMech. Ongoing engagement has strengthened the relationship and understanding of the companies research interests and relevance of SofTMech to addressing them.
Impact No outputs to date. This collaboration is at an early stage of development. Projects have been identified and Vascutek have confirmed cash and in kind support for a CDT that SofTMech are developing. The SofTMech centre is multidisciplinary and discussion, with Vascutek, has involved academics from Mathematics, Statistics and Engineering. To date no formal agreements have been signed or agreed.
Start Year 2017
 
Description Industrial Engagement with Vascular Flow Technologies. 
Organisation Vascular Flow Technologies
Country United Kingdom 
Sector Private 
PI Contribution SofTMech organised an industry Dialogue which was held in November 2017. Vascular Flow Technologies expressed an interest but were unable to attend. A follow up conversation took place in February 2018, to explore opportunities for collaboration.
Collaborator Contribution Vascular Flow Technologies have confirmed their intention to be considered as an industrial partner on the Centre for Doctoral Training that SofTMech is developing. The support would take the form of work placements and short research projects in line with our R&D project pipeline. The CDT application was not taken forward. However development of this relationship is ongoing.
Impact No outputs to date. This collaboration is at an early stage of development.
Start Year 2017
 
Description NHS Research Scotland 
Organisation NHS Research Scotland
Country United Kingdom 
Sector Public 
PI Contribution Following successful industry dialogue, in 2017, SofTMech investigators engaged with NHS Research Scotland (NRS) via reciprocal visits to explore areas of interest. NHS Research Scotland promotes and supports excellence in clinical and translational research in Scotland so that patients can benefit from new and better treatments. Ongoing Engagement has led to NRS becoming a partner on recent SofTMech International centre to centre application. This application EP/S030875/1was successful and a £1.6m EPSRC grant awarded. NRS introduced SofTMech PIs to Scottish Health Innovations Ltd.
Collaborator Contribution NHS Research Scotland (NRS) has committed staff time to promote and raise awareness of SofTMech within their network of clinicians.
Impact None at present
Start Year 2017
 
Description Pittsburgh 
Organisation University of Pittsburgh
Country United States 
Sector Academic/University 
PI Contribution As a result of a Softmech Feasability Fund Award, collaborative research on modelling bladder growth and remodelling began in March 2018.
Collaborator Contribution PhD student from Pittsburgh visited Sheffield for 3 weeks to collaborative on developing mathematical model of bladder growth and remodelling (March 2018). Continued research in Pittsburgh.
Impact Two conference papers presented (BAMC 2018, WCB 2018) and two abstracts submitted (SB3C).
Start Year 2018
 
Description Reserach Centre, University Hospital, University of Bordeaux. 
Organisation Bordeaux University Hospital (CHU Bordeaux)
Country France 
Sector Hospitals 
PI Contribution We discuss techniques and experiments and share data.
Collaborator Contribution So far, they advise on protocols and experimental design.
Impact None yet.
Start Year 2016
 
Description Scottish Health Innovations Ltd 
Organisation Scottish Health Innovations Ltd (SHIL)
Country United Kingdom 
Sector Private 
PI Contribution SofTMech investigators were introduced to NHS Research Scotland (NRS) has committed staff time to promote and raise awareness of SofTMech within their network of clinicians.via engagement with NHS Research Scotland.SHIL work in partnership with NHS Scotland to identify, protect, develop and commercialise healthcare innovations to improve patient care.Ongoing Engagement has led to SHIL becoming a partner on recent SofTMech International centre to centre application. . This application EP/S030875/1 was successful and a £1.6m EPSRC grant awarded.
Collaborator Contribution SHIL has committed staff time to promote and raise awareness of SofTMech within their network of clinicians.
Impact No outputs yet
Start Year 2017
 
Title Glasgow Cine Strain estimation from cine images--deformation tracking 
Description Since 2012, Dr. Hao Gao, together with Prof. Colin Berry and Prof. Xiaoyu Luo, have been designing a novel method for tracking myocardial deformation using cardiac magnetic resonance cine imaging. Pixel-wise strain for myocardial deformation was estimated by incorporating both local and global myocardial features from cine images based on an in-house intensity-based b-spline deformable registration method. The algorithms were published in 2014 (https://www.ncbi.nlm.nih.gov/pubmed/24922458). Later, Dr. Gao developed an user-friendly interface for using in clinic, which are currently evaluated by our clinical collaborators for the accuracy and reliability. Results on healthy volunteers are reported in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150576/. Following studies on patients with myocardial infarction are under analysis. Currently the package is shared within the group. 
Type Of Technology Software 
Year Produced 2016 
Impact Deformation-tracking could potentially obviate the need for bespoke strain sequences, reducing scanning time and is more reproducible than feature-tracking. 
 
Description 6th International Conference on Computational and Mathematical Biomedical Engineering, Tohoku University, Katahira Campus, Sendai, Japan, 10 -12 June 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor Chaplain was a plenary speaker at the 6th International Conference on Computational and Mathematical Biomedical Engineering, CMBE 2019, Tohoku University, Katahira Campus, Sendai, Japan, 10 -12 June 2019. He gave a talk on multiscale modelling of cancer growth and spread, tissue invasion and metastasis.
Year(s) Of Engagement Activity 2019
URL https://www.compbiomed.net/2019/
 
Description A Dialogue on Cancer 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This workshop was the second in a series of focussed meetings, co-funded by the EPSRC Network 'Predictive mOdelling for hEalthcare through MathS (POEMS)' and Centre for Multiscale Soft Tissue Mechanics (SoftMech). The focus of the workshop will be to bring together multidisciplinary groups (e.g. clinicians, biologists and modellers) and initiate dialogues and collaborations across disciplines, on challenges in relation to the mechanical and physical aspects of cancer.
Year(s) Of Engagement Activity 2016
URL http://softmech.org/news/headline_499405_en.html
 
Description Biomechanics and Biophysics of Living Matter 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact In this workshop, it will mainly cover the biophysics/biomechanics of biofilms, bacteria, cells , soft tissues and cell-materials  interactions.   


We welcomed biologists, physicists, engineers, computing scientists and mathematician to attend. In this workshop, we invited the delegates to actively
participate the discussions that provide interesting physical insights  including but not limited to the following areas.

 

- Nanobiomechanics of cells

- Mechanobiology of cell-cell and cell-ECM interactions

- Mechanobiology at the cellular and tissue scale, using  experimental and modelling approaches.

- Mechanics of bacteria, biofilms and biopolymer meshes

-Antimicrobial surfaces 

 

Jinju (Vicky) Chen (Organiser, Newcastle University)
Year(s) Of Engagement Activity 2020
 
Description Cancer talk, Turnberry 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Talk to Scottish Power employees at their large annual fundraiser
Year(s) Of Engagement Activity 2018
 
Description Cardiovascular Research Day - Public Engagement, 14 March 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact Public engagement day in our hospital
Year(s) Of Engagement Activity 2017
 
Description Cside 2018: Competitive statistical inference for differential equations 26th Nov 2018, Dr Benn Macdonald 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Cside 2018: Competitive statistical inference for differential equations 26th Nov 2018 was organised by Dr Benn Macdonald at the University of Glasgow Mathematics and Statistics Building. Models developed within SofTMech were used.
Year(s) Of Engagement Activity 2018
URL https://www.gla.ac.uk/schools/mathematicsstatistics/events/conferences/cside2018/
 
Description DIALOGUE WITH CLINICIANS ON RETINAL HAEMORRHAGE 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This one-day event brought together expert clinicians and modellers to discuss challenges in quantifying the onset and severity of retinal haemorrhage, along with its likely cause. In particular, the event involved presentations by leading clinicians on current medical understanding of the causes of retinal haemorrhage and by modellers on recent advances in modelling the retinal circulation and in predicting the response of the eye and optic nerve to a traumatic brain injury.

This event was organized by Dr Peter Stewart
Year(s) Of Engagement Activity 2019
 
Description Dialogue on Heart Failures 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact 22nd April 16 brought together clinicians and modellers and created a focus to identify some of the crucial challenges in heart failure and disease over the next 20 years.
Year(s) Of Engagement Activity 2016
URL http://www.softmech.org/events/2016-04-22dialogueonheartfailure/
 
Description European Researchers Night 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact On September 30th SofTMech participated in the European Researcher Night outreach event at the Glasgow Science Centre. With attendance from over ten thousand visitors it was an excellent opportunity to present SofTMech to the public.
Year(s) Of Engagement Activity 2016
URL http://www.softmech.org/news/headline_497928_en.html
 
Description Explorathon 2018 - european researchers night 2018 glasgow 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Dr Andrey Melnik and Jay MacKenzie presented for SofTMech.
Year(s) Of Engagement Activity 2018
URL http://www.explorathon.co.uk/glasgow/
 
Description Five EPSRC Maths-Healthcare Centres Meeting. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact FIVE EPSRC Maths-Healthcare Centres (Cambridge, Exeter, Imperial, Liverpool and SofTMech), met, (in Glasgow), to share experiences and to explore joint future funding opportunities. As a follow up the Liverpool, Cambridge and SofTMech Centres are outlining an EPSRC programme grant proposal based around physiologically-based image analysis.
Year(s) Of Engagement Activity 2018
 
Description Glasgow SofTMech / Liverpool Centre for Mathematics in Healthcare joint sandpit meeting Glasgow 2018-04-04 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Outreach and user engagement meeting between the Glasgow SofTMech / Liverpool Centre for Mathematics in Healthcare EPSRC centres to be held in Glasgow on 4/5 April 2018.The aim is to share methodology and results of mutual interest and to explore avenues for collaboration. Organised by Radostin Simitev and the SofTMech Outreach Committee.
Year(s) Of Engagement Activity 2017
 
Description Industry Dialogue 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Industrial engagement: SofTMech organised an Industry Dialogue, 24th November 2017. The aim was to invite a small group, (~50) and to create the opportunity for quality/in depth discussion on topics of mutual interest.Key outcomes: include strengthening of links with industrial collaborators GSK Pharmaceuticals who and development of links with new collaborators i.e. NHS Research Scotland, Vascutek Ltd and Vascular Flow Technologies. Follow up meetings have occurred with Vascutek and Vascular Flow Technologies which has led to the identification of research projects and commitment, from both Companies, to support the development of a SofTMech CDT. NHS Research Scotland have indicated their support for the planned SofTMech CDT and their willingness to promote and support SofTMech. The event helped strengthen the links to GSK by exploring new avenues of interest.
Year(s) Of Engagement Activity 2017
 
Description Insigneo Showcase Event 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Members of SofTMech lead by Dr Paul Watton organised and presented at an workshop within the larger Insigneo Showcase Event 2018. The Showcase is organised by the partner institution University of Sheffield.
Year(s) Of Engagement Activity 2018
URL https://insigneo.org/event/insigneo-showcase-2018/
 
Description Invited talk at the University of Southampton which was live-streamed and recorded 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This is a talk given that the University of Southampton to disseminate research outputs obtained in WP4 of the Softmech project. The talk was live-streamed and recorded; the recording can be accessed here:
https://coursecast.soton.ac.uk/Panopto/Pages/Viewer.aspx?id=f77021fe-662c-427c-9c7a-a9ea0088932a
Year(s) Of Engagement Activity 2019
URL https://tinyurl.com/y2sagn8q
 
Description Joint EPSRC Multisim-Softmech workshop, June 18-20, 2018, University of Sheffield. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A 3 day workshop that provided a forum to review the progress of state of the art multi-scale modelling of hard and soft tissues and discuss challenges and opportunities in the area.
Year(s) Of Engagement Activity 2018
URL http://multisim-insigneo.org/events/smw18/
 
Description Joint SofTMech Liverpool LCMH Meeting First Joint SofTMech Liverpool LCH Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact On the 4th April, 2018 the first of two meetings was held between SofTMEch and Liverpool CMH. In order for both centres to have a better understanding of the work of the other centre Part 1 of the programe was devoted to Research Talks. The meeting commenced with two 10-minute overview talks, one from each centre. There was also a poster session. After the talks a round-table allowed discussion on areas of collaboration. Topics for the round-table discussion were: opportunities for collaborative grants, possible PhD student exchange visits.
Year(s) Of Engagement Activity 2018
URL http://www.softmech.org/events/headline_584998_en.html
 
Description MODELLING & EXPERIMENTS IN DRUG DELIVERY SYSTEMS (MEDDS) 3-5 September 2018, University of Glasgow, UK, Dr Sean McGinty 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This 3 day workshop brought together theoretical and experimental researchers, industrialists and clinicians working broadly in the area of drug delivery, so that the problems that persist may be identified from an 'end-user' point of view, new challenges laid down and successfully tackled.
Year(s) Of Engagement Activity 2018
URL https://www.gla.ac.uk/research/az/cmals/newsevents/meddsworkshop/
 
Description Main twitter feed for EPSRC Centre for Multiscale Soft Tissue Mechanics - with application to heart & cancer 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Main Twitter feed for SofTMech
Year(s) Of Engagement Activity 2018
URL https://twitter.com/SofTMech
 
Description Main website of the project - www.softmech.org 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Main Website of the EPSRC Centre for Multiscale Soft Tissue Mechanics - with application to heart & cancer.
Year(s) Of Engagement Activity 2016,2017,2018,2019
URL http://www.softmech.org
 
Description Mason as a STEM Ambassador in Primary school 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Louise Mason, acted as a STEM Ambassador in Primary school teaching 'Viscoelasticity - Engineering Medicine to Spacecraft,' Crosshouse Primary School, East Kilbride, UK, October 2017.
Year(s) Of Engagement Activity 2017
 
Description Media interviews - multiple 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Multiple media contacts following late breaking trial presentation
Year(s) Of Engagement Activity 2018
 
Description Minisymposium on Integrative Modelling of Soft-Tissue Mechanobiology, 5th International Conference on Computational & Mathematical Biomedical Engineering (CMBE17), Pittsburgh, April 10-12, 2017 organised by Dr Paul Watton 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Minisymposium to showcase work and to encourage collaboration
Year(s) Of Engagement Activity 2018
 
Description Minisymposium on Integrative Modelling of Soft-Tissue Mechanobiology, 7th International Conference in Vietnam on the Development of Biomedical Engineering, International University-Vietnam National University, HCMC, Vietnam, 27-29 June 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact tba
Year(s) Of Engagement Activity 2018
 
Description Patient Participation Day 20th May 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Background
SofTMech's Mid-Term review highlighted the excellent quality of the research and that the centre has provided a focal point, and is very proactive in impact, outreach, and training activities. A key future activity is to inform patients and seek their views on our research and its impact via Patient Engagement Days.
The first such meeting was organised by the SofTMech Executive Director, the Chair of the Outreach Committee, 2 Clinicians, 2 Head Research Nurses from two large Glasgow Hospitals and the SofTMech secretary and was aimed at Cardiology patients. The event was held at the Golden Jubilee National Hospital as many of the patients would be familiar with it, and it has good access appropriate facilities.

The Patient Participation Day
On the 20th May 2019 the Patient Engagement day was held. Sixteen patients attended. Following a general introduction, there were eight 15-minute talks with opportunities for questions after each talk. In addition, there were hands-on Models of the Heart, and demonstrations by SofTMech PhD students and postdoctoral researchers. The Day started at 10am and the many questions led to the day running over and finishing at 2.45 pm.
Titles of presentations
• Clinical decision support with mathematical and statistical modelling: Dirk Husmeier

• The digital twin of your heart: Xiaoyu Luo and Hao Gao

• Blood flow in arteries: Nicholas Hill

• Bleeding in the eye following brain injury: Peter Stewart

• The challenges of fixing a "broken" heart: Ana Costa

• Imaging the heart: Colin Berry

• Simulating cell migration: Matthew Neilson

• Electricity in the heart: Radostin Simitev

Feedback
Feedback forms were handed out at the end of the day. Feedback was very thorough and detailed with the main points being:
- Relate talks to patient benefit
- Include small group discussion to provide patient insight goals
- Include patient who has taken part in research
- Include sign-ups for research projects
- Biscuits on arrival and sufficient milk
- Include more demo and visual aids
- Fewer speakers with more time
Year(s) Of Engagement Activity 2019
URL http://www.softmech.org/events/headline_596271_en.html
 
Description PubPhD talk "Can cells be evil?" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact "Pub PhD" talk "Can cells be evil?"
Year(s) Of Engagement Activity 2017
 
Description SIG EVENT ON FLUID MECHANICS OF THE EYE: TUESDAY 26TH TO WED 27TH MARCH 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The event was an informal study group considering two problems - one related to the cornea and the front of the eye (Problem 1) and one related to the retina and the back of the eye (Problem 2).

Organized by Dr Peter Stewart
Year(s) Of Engagement Activity 2019
 
Description SOFT TISSUE MODELLING WORKSHOP 5-7 June 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Study participants or study members
Results and Impact The 4th workshop took place from Wednesday 5th to Friday 7th June. The workshop focused on the most recent advances in the field of soft tissue mechanics, with a clear vision of the landscape of multiscale soft tissue modelling and both fundamental and translational research. The workshop provided a unique environment for cross-talk, enabling the sharing of novel ideas and expertise necessary for the future advancement of soft tissue modelling.
Year(s) Of Engagement Activity 2019
URL http://www.softmech.org/events/headline_587639_en.html
 
Description STEM for Britain 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact SofTMech PhD student Louise Mason presented a poster at the prestigious STEM for Britain event held in UK Parliament. Louise was awarded the gold medal for Engineering for her poster entitled `Investigating the viscoelastic properties of complex materials and cells to study cancer migration'. This event was attended by MPs and policy makers from UK Parliament, which sparked questions and discussion.
Year(s) Of Engagement Activity 2018
URL http://www.setforbritain.org.uk/
 
Description SofTMech December Seminars Series Glasgow 2017-Dec 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact SofTMech organised a Seminar Series in Dec 2017 with two high profile external speakers as follows (1) Prof. Nir Gov "Modelling Collective Cell Migration: Clusters and Monolayers"; (2) Dr. Yanlan Mao "Getting in Shape: in vivo and in silico studies of tissue mechanics in growth control". SofTMech Members and affiliates from the School of Mathematics and Statstics U Glasgow as well as and CMALS attended.
Year(s) Of Engagement Activity 2017
 
Description SofTMech at European Researchers Night Glasgow 2017-09-29 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact 29th September 2017 SofTMech CIs and PGR students participated with poster displays and a stall in the European Researchers Night Glasgow.
Year(s) Of Engagement Activity 2017
URL http://www.softmech.org/news/headline_555906_en.html
 
Description SofTMech website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Set up a SofTMech website. The website is a main vehicle for dissemination of results, news, events information, and general outreach activities.
Year(s) Of Engagement Activity 2016,2017
URL http://www.softmech.org
 
Description SoftMech & Multisim Tissue Mechanics Workshop (3 days), University of Sheffield, UK, June 18-20, 2018: Organiser Dr Paul Watton 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact To showcase new developments and encourage collaboration
Year(s) Of Engagement Activity 2018
URL https://insigneo.org/event/insigneo-showcase-2018/
 
Description Stakeholder Engagement Day 8th May 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact SofTMech held a Stakeholder Engagement Day on the 8th May, 2019 at the University of Glasgow. The event was designed for a wider audience including industry, clinicians and academics.
The event was well attended by a range of speaker including academics, industry, clinicians and funders. Key speakers included Dr Stephen Meader, MRC, who spoke about the importance of
translational activities from a funder perspective and Dr Tom Robinson, EPSRC who highlighted EPSRC funding options i.e. support for translational activities.
Year(s) Of Engagement Activity 2019
URL http://www.softmech.org/events/headline_627300_en.html
 
Description The British Applied Mathematics Colloquium (BAMC), 26th-29th March 2018 at the School of Maths and Statistics, University of St Andrews, organised by Professor Mark Chaplain. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The BAMC is the UK's annual multidisciplinary applied mathematics meeting. The meeting has a history going back to 1959, founded by Sir James Lighthill as the British Theoretical Mechanics Colloquium. The meeting has since broadened to cover all aspects of modern applied mathematics. The event includes 18 mini-symposia. SofTMech CIs are leading the following mini-symposia: Title: Multiscale Soft Tissue Modelling: Upscaling from Cell to Tissue; Organisers: Dr P Stewart (Glasgow), Professor R Ogden (Glasgow), Professor S McDougall (Heriot-Watt) & Dr P Watton (Sheffield). Title:Multiscale Soft Tissue Modelling: Circulation and Fluid-Structure Interaction; Organisers: Prof X Luo (Glasgow) & Prof N Hill (Glasgow); Title:Multiscale Soft Tissue Modelling: Cardiac Electrophysiology and Active Contraction; Organiser: Dr R Simitev (Glasgow); Title: Multiscale Soft Tissue Modelling: Parameter Inference;Organisers: Prof D Husmeier (Glasgow) & Dr H Gao (Glasgow),
,
Year(s) Of Engagement Activity Pre-2006,2006,2007,2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018
URL http://www.mcs.st-andrews.ac.uk/~bamc2018/
 
Description Third Workshop on Soft Tissue Modelling Glasgow 2017-07-07/09 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The Third Soft Tissue Modelling Workshop in Glasgow provided a research forum for modelling specialists and medical experts to discuss and exchange ideas on state-of-the-art developments and challenges in the field of soft tissue modelling, with particular applications to tissues in the cardiovascular system and tissues affected by cancer.
Year(s) Of Engagement Activity 2017
URL http://www.softmech.org/events/thirdworkshoponsofttissuemodelling/
 
Description https://www.holyrood.com/news/view,women-suffering-and-dying-because-of-inequalities-in-heart-disease-diagnosi_10869.htm 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact https://www.holyrood.com/news/view,women-suffering-and-dying-because-of-inequalities-in-heart-disease-diagnosi_10869.htm
Year(s) Of Engagement Activity 2019,2020
URL https://www.holyrood.com/news/view,women-suffering-and-dying-because-of-inequalities-in-heart-diseas...