Electrophysiological-mechanical coupled pulses in neural membranes: a new paradigm for clinical therapy of SCI and TBI (NeuroPulse)
Lead Research Organisation:
University of Oxford
Department Name: Engineering Science
Abstract
Traumatic Brain Injury (TBI) is a major public health issue with over 10m incidents resulting in death or in hospitalisation annually occurring worldwide. In Europe, an average incidence of 235/100,000 per year is estimated, with most countries experiencing an incidence in the range of 150-300/100,000, leading to a direct healthcare cost of EUR2.9b per year. The World Health Organization estimates that TBI will surpass many diseases as the major cause of death and disability by 2020. The other constituent of the central nervous system is the spinal cord. Damage to the spinal cord, or Spinal Cord Injury (SCI), thus shares many similarities with TBI, but also independently leads to pain and/or motor impairments ranging from incontinence to paralysis. In addition to potentially occurring simultaneously with TBI in many situations, mild SCI alone can cost in the US as much as $334,170 the first year followed by $40,589 the subsequent years. Severe SCIs reach the staggering figure of $1m for the first year alone. In the UK, this corresponds to an overall cost of £1b per year. A direct consequence of TBI and SCI, but of a much wider scope, pain management is discretely posing itself as one of the most important healthcare costs in the UK, reaching an evaluated £774m in direct cost and £4,338m in employment related cost for back pain alone in 1998, which, extrapolated to this decade, implies a total current cost of back pain in excess of £10b a year.
The recent increase in the number of research campaigns on TBI and SCI has drastically improved the understanding of the coupled role of micromechanics and electrophysiology at the neuron level. More particularly, the PI of this proposal has focussed his recent research on the development of in silico models aimed at capturing the electrophysiological alterations of neurons when submitted to a mechanical insult. In parallel to this, recent findings suggesting a direct coupling between mechanical vibration and electrical pulses in healthy neuron action potential propagation open the door to a new series of evolution for this simulation platform, as well as potentially a novel approach for the understanding of TBI and SCI. However, the intrinsic relationship between mechanical vibrations (among which ultrasounds) and their biophysical implications is still widely ignored in this context. Said otherwise, whereas the effect of mechanical damage on the neuronal functional properties is currently heavily studied, the intrinsic coupling between mechanics and electrophysiology in healthy neurons is still not fully understood. As a direct consequence, the effect of functional alteration due to a mechanical insult on the vibrational mechanical properties of a neuron has so far been fully ignored.
NeuroPulse thus aims at developing and utilising state of the art modelling approaches for the study of electrophysiological and mechanical coupling in a healthy and mechanically damaged axon, nerve and eventually spinal cord and brain white matter tract. The resulting in silico platform will be calibrated and validated by means of a comprehensive experimental programme in collaboration with the Department of Physics of the University of Oxford. Two teams of clinical project partners in Oxford and Cambridge will participate to the analysis of the results for direct applications in a clinical setting. More specifically, the project will aim at a) evaluating the role of this newly identified electrophysiological-mechanical coupling in pulses in TBI/SCI related functional deficits and, as a pilot application, b) at posing the bases for the design of a device leveraging this coupling for spinal cord pain management by cancelling effect (and reversibly, for signal enhancement). Both objectives will considerably benefit the medical community in the diagnosis, prognosis, and treatment of TBI and SCI, while providing new avenues for non-invasive electrophysiological control.
The recent increase in the number of research campaigns on TBI and SCI has drastically improved the understanding of the coupled role of micromechanics and electrophysiology at the neuron level. More particularly, the PI of this proposal has focussed his recent research on the development of in silico models aimed at capturing the electrophysiological alterations of neurons when submitted to a mechanical insult. In parallel to this, recent findings suggesting a direct coupling between mechanical vibration and electrical pulses in healthy neuron action potential propagation open the door to a new series of evolution for this simulation platform, as well as potentially a novel approach for the understanding of TBI and SCI. However, the intrinsic relationship between mechanical vibrations (among which ultrasounds) and their biophysical implications is still widely ignored in this context. Said otherwise, whereas the effect of mechanical damage on the neuronal functional properties is currently heavily studied, the intrinsic coupling between mechanics and electrophysiology in healthy neurons is still not fully understood. As a direct consequence, the effect of functional alteration due to a mechanical insult on the vibrational mechanical properties of a neuron has so far been fully ignored.
NeuroPulse thus aims at developing and utilising state of the art modelling approaches for the study of electrophysiological and mechanical coupling in a healthy and mechanically damaged axon, nerve and eventually spinal cord and brain white matter tract. The resulting in silico platform will be calibrated and validated by means of a comprehensive experimental programme in collaboration with the Department of Physics of the University of Oxford. Two teams of clinical project partners in Oxford and Cambridge will participate to the analysis of the results for direct applications in a clinical setting. More specifically, the project will aim at a) evaluating the role of this newly identified electrophysiological-mechanical coupling in pulses in TBI/SCI related functional deficits and, as a pilot application, b) at posing the bases for the design of a device leveraging this coupling for spinal cord pain management by cancelling effect (and reversibly, for signal enhancement). Both objectives will considerably benefit the medical community in the diagnosis, prognosis, and treatment of TBI and SCI, while providing new avenues for non-invasive electrophysiological control.
Planned Impact
NeuroPulse encompasses three of the four pillars of the Healthcare Technologies Grand Challenges: a) the development of future therapies aimed at leveraging neuron electrophysiological-mechanical coupling to modify or quantify electrophysiological properties by control over the mechanical properties, b) treatment optimisation by potentially inexpensive non-invasive pain treatment and possibly functional deficit detection, and c) transforming community health and care by alleviating the need for primary care to "second guess" the patients' symptoms (as is unfortunately often the case in TBI), and provide an objective roadmap for damage quantification. Doing so, NeuroPulse will help decrease the societal and economic burden of TBI, SCI and pain management in the UK, and worldwide. The tremendous economic implications of these efforts for the UK (see Summary Abstract) and the envisioned translational activity will be achieved as follows.
The current network and team of the PI already involve many scientific disciplines (e.g., Engineering, Mathematics, Physics and Biology), including Co-I Prof Contera from the Department of Physics (in NeuroPulse, Prof Contera will provide her state-of-the-art experimental expertise to support the numerical efforts of the PI). Additionally, over the course of his efforts to create the International Brain Mechanics and Trauma Lab (IBMTL), the PI has consolidated a strong network of neurosurgeons and neuroscientists. With the support of University of Oxford's Department of Engineering Science, NeuroPulse will build the ideal framework (until now merely virtual) to concretise their dedicated interest in clinically driven engineering solutions by transforming the IBMTL into a physical multisciplinary lab.
In addition, so as to guarantee a direct implication of the medical (and military) community into the envisioned pilot application, Dr Jenkins, an Army Medical Officer lecturing in Neurology and a Fellow in Medicine in St Hugh's College was identified as a project partner. He is a member of the University of Oxford Multiple Sclerosis (MS) Neuropathology Research Group focussed on multidisciplinary studies of brain and spinal cord tissue in the context of MS, and aimed at ensuring that the understanding derived from these studies translates into ideas for improved treatments of patients. Dr Jenkins will be in charge of centralising the additional participation of Mr Lawrence, a consultant paediatric neurosurgeon in the John Radcliffe Hospital focussing on biomarkers identification of TBI symptoms, as well as a novel unique collaboration with University of Cambridge Prof Menon, Head of Division of Anaesthesia and Acute Care Lead in the Cambridge NIHR Healthcare Technology Cooperative for Acute Brain Injury, and Dr Ercole, consultant anaesthetist specialised in resuscitation and neurocritical care. Prof Menon is Co-Chair of the European Brain Injury Consortium, one of the coordinators of the current CENTER-TBI study and Co-Chair of the Acute Brain Injury program at Cambridge. Dr Ercole is also part of the CENTER-TBI consortium, and leads a research theme on mechanical, physiological, and metabolic modelling of human brain injury. In addition, Prof Menon's role as Head of the Division of Anaesthesia will provide access to a productive pain research group and facilitate the exploitation of research outputs that relate to pain management or more generally electrophysiological control by mechanical means. His involvement will also provide a means of disseminating NeuroPulse's research to the broader clinical community through his role in the NIHR Cambridge Biomedical Research Centre.
Finally Dr Malboubi will be hired as a Researcher Co-I to leverage the expertise and wide research connectivity of the medical partners by ensuring the dissemination of the research outputs from NeuroPulse, and identifying with the PI opportunities for translational activity and grant funding.
The current network and team of the PI already involve many scientific disciplines (e.g., Engineering, Mathematics, Physics and Biology), including Co-I Prof Contera from the Department of Physics (in NeuroPulse, Prof Contera will provide her state-of-the-art experimental expertise to support the numerical efforts of the PI). Additionally, over the course of his efforts to create the International Brain Mechanics and Trauma Lab (IBMTL), the PI has consolidated a strong network of neurosurgeons and neuroscientists. With the support of University of Oxford's Department of Engineering Science, NeuroPulse will build the ideal framework (until now merely virtual) to concretise their dedicated interest in clinically driven engineering solutions by transforming the IBMTL into a physical multisciplinary lab.
In addition, so as to guarantee a direct implication of the medical (and military) community into the envisioned pilot application, Dr Jenkins, an Army Medical Officer lecturing in Neurology and a Fellow in Medicine in St Hugh's College was identified as a project partner. He is a member of the University of Oxford Multiple Sclerosis (MS) Neuropathology Research Group focussed on multidisciplinary studies of brain and spinal cord tissue in the context of MS, and aimed at ensuring that the understanding derived from these studies translates into ideas for improved treatments of patients. Dr Jenkins will be in charge of centralising the additional participation of Mr Lawrence, a consultant paediatric neurosurgeon in the John Radcliffe Hospital focussing on biomarkers identification of TBI symptoms, as well as a novel unique collaboration with University of Cambridge Prof Menon, Head of Division of Anaesthesia and Acute Care Lead in the Cambridge NIHR Healthcare Technology Cooperative for Acute Brain Injury, and Dr Ercole, consultant anaesthetist specialised in resuscitation and neurocritical care. Prof Menon is Co-Chair of the European Brain Injury Consortium, one of the coordinators of the current CENTER-TBI study and Co-Chair of the Acute Brain Injury program at Cambridge. Dr Ercole is also part of the CENTER-TBI consortium, and leads a research theme on mechanical, physiological, and metabolic modelling of human brain injury. In addition, Prof Menon's role as Head of the Division of Anaesthesia will provide access to a productive pain research group and facilitate the exploitation of research outputs that relate to pain management or more generally electrophysiological control by mechanical means. His involvement will also provide a means of disseminating NeuroPulse's research to the broader clinical community through his role in the NIHR Cambridge Biomedical Research Centre.
Finally Dr Malboubi will be hired as a Researcher Co-I to leverage the expertise and wide research connectivity of the medical partners by ensuring the dissemination of the research outputs from NeuroPulse, and identifying with the PI opportunities for translational activity and grant funding.
Organisations
- University of Oxford, United Kingdom (Collaboration, Lead Research Organisation)
- University College London, United Kingdom (Collaboration)
- John Radcliffe Hospital, United Kingdom (Collaboration)
- Addenbrooke's Hospital (Collaboration)
- Oxford University Hospitals NHS Trust, United Kingdom (Project Partner)
- University of Cambridge, United Kingdom (Project Partner)
Publications

Al-Rekabi Z
(2018)
Multifrequency AFM reveals lipid membrane mechanical properties and the effect of cholesterol in modulating viscoelasticity
in Proceedings of the National Academy of Sciences

Baker RE
(2018)
Mechanistic models versus machine learning, a fight worth fighting for the biological community?
in Biology letters

Bing Y
(2020)
Medical imaging based in silico head model for ischaemic stroke simulation.
in Journal of the mechanical behavior of biomedical materials

Chen H
(2019)
Computational model of the mechanoelectrophysiological coupling in axons with application to neuromodulation.
in Physical review. E

Chen H
(2019)
Computational model of the mechanoelectrophysiological coupling in axons with application to neuromodulation.
in Physical review. E


Garcia-Gonzalez D
(2019)
Energy based mechano-electrophysiological model of CNS damage at the tissue scale
in Journal of the Mechanics and Physics of Solids

Jerusalem A
(2019)
Electrophysiological-mechanical coupling in the neuronal membrane and its role in ultrasound neuromodulation and general anaesthesia.
in Acta biomaterialia

Jerusalem A
(2018)
"Mind control using sound waves? We ask a scientist how it works"

Jerusalem A
(2018)
"It's moving!!, It's moving!!" is dead, long live "It's alive!! It's alive!!"
in ECCOMAS Newsletter
Description | We have demonstrated that under quasi-static mechanical loading, the neuronal activity (in terms of action potential) is altered. Some features are reversible whereas some appear to be irreversible. Numerical work has demonstrated how dynamic mechanical loading such as ultrasound can enhance or impede action potential propagation. |
Exploitation Route | This has implications in cases where the brain is subjected to a compressive state (e.g., swelling). Current work is aiming at identifying better the next steps for these results. |
Sectors | Healthcare |
Description | The basic science research work has important implications for the field of ultrasound neuromodulation. The WEF (building on the preaward 2014 Young Scientist award) has conducted an interview asking the PI (Antoine Jerusalem) about this type of clinical intervention, how this works, the danger, etc. This has led to significant exposure internationally. Since then, the PI has been involved in many meetings and workshops related to ultrasound neuromodulation (including the 1st FUN workshop organised by the PI and colleagues in Oxford). This is transitioning slowly into practical impact in the clinical world, i.e., a stronger interest on the basic science behind the technique and how this could be leveraged to better use it. Note finally that the proposed multiphysics philosophy brought forward by this project has been carried onto the journal Brain Multiphysics created by the PI and colleague Prof. Goriely |
First Year Of Impact | 2018 |
Sector | Healthcare,Other |
Impact Types | Societal,Policy & public services |
Description | EU Parliament even participation (two of them) |
Geographic Reach | Europe |
Policy Influence Type | Participation in a advisory committee |
Description | University Challenge See Fund: SIM TBI award |
Amount | £61,506 (GBP) |
Funding ID | UCSF 433 |
Organisation | University of Oxford |
Department | Oxford University Innovation |
Sector | Private |
Country | United Kingdom |
Start | 09/2017 |
End | 08/2018 |
Description | Wellcome Institutional Strategic Support Fund |
Amount | £30,378 (GBP) |
Funding ID | 0006331 |
Organisation | University of Oxford |
Sector | Academic/University |
Country | United Kingdom |
Start | 09/2019 |
End | 09/2019 |
Title | MECAXON |
Description | MECAXON simulates the conduction of electro-physiological pulses and mechanical pulses in neuronal axons, as well as the interactions between two pulses. Main features of the code: Solved by finite element method in Matlab Capable of modelling the conduction of both electro-physiological and mechanical pulses in the axon Capturing the direct and reverse flexoelectric effects that occurs in the neuronal membrane Can be potentially used to explain physical phenomena related to the mechano-electrophysiological coupling in neurons, such as membrane deformation during action potential propagation and ultrasound neuromodulation |
Type Of Material | Computer model/algorithm |
Year Produced | 2018 |
Provided To Others? | Yes |
Impact | Model is being used to explain controversy of multiphysics coupling in neuronal membrane and explain some of the mechanisms underlying ultrasound neuromodulation |
URL | https://process.innovation.ox.ac.uk/software/p/15910/mecaxon-academic/1 |
Title | VUMAT: constitutive model for soft biological tissues |
Description | This code provides the explicit implementation of a constitutive model to define the mechanical behaviour of soft tissues. Main features of the code: Implemented in a VUMAT material subroutine for Abaqus/Explicit Uncoupled volumetric and isochoric responses Developed for finite deformations Strain rate dependency Continuum damage Can be used to relate mechanical deformation to other physical phenomena through energetic terms, such as alterations in electrophysiological responses |
Type Of Material | Computer model/algorithm |
Year Produced | 2018 |
Provided To Others? | Yes |
Impact | The model is developed within a thermodynamically consistent framework, provides energetic variables that can be linked to other physics of soft tissues (such as electrophysiology) |
URL | https://process.innovation.ox.ac.uk/software/p/16428/vumat/1 |
Description | Dr. Brad Treeby |
Organisation | University College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We started collaborating with Dr. Treeby from UCL to implement the multiscale multiphysics model of electrophysiological-mechanical coupling in K-wave (Brad is one of the creators of K-wave). So far, we have met once and will be implementing the coupling to electrophysiology in K-wave soon. |
Collaborator Contribution | So far, we have met once and will be implementing the coupling to electrophysiology in K-wave soon. |
Impact | This work has not led to any outcome yet. It will be focus on the numerical implementation only. |
Start Year | 2019 |
Description | Experimental study of effective parameters for ultrasound neuromodulation of cultured neurons |
Organisation | University College London |
Department | Department of Medical Physics and Biomedical Engineering |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Collaboration on in vitro ultrasound setup for cultured neurons |
Collaborator Contribution | Technical assitance and loan of 1064mm Q-switched DPSS laser STA version. They provided the ultrasonic probe (laser and fibres with coatings) and measured the generated ultrasound. |
Impact | This collaboration has been put on hold as the ultasound setup was not fully controlled. We might get back to it in a year or so. |
Start Year | 2017 |
Description | Prof. Jerome Sallet and Dr. Lennard Verhagen |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We started a collaboration with Prof. Sallet and Dr. Verhagen in terms of the application of the developed software in NeuroPulse. We meshed fully a brain model from monkey that is being studied for neuromodulation. |
Collaborator Contribution | They provided so far the scan images of the animal brain, and the application of interest for us to test our resulting model. |
Impact | ongoing |
Start Year | 2018 |
Description | Traumatic Brain Injury Medical partners |
Organisation | Addenbrooke's Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | The NeuroPulse project envisioned to establish the basis for a collaboration with both hospitals. I organised a few meetings to establish the foundations for NeuroPulse to develop clinically relevant outputs. A meeting was organised in Cambridge for the NeuroPulse academics to present their work. |
Collaborator Contribution | Another day meeting was organised in Oxford at the end of 2016 to discuss anaesthesia in the framework of NeuroPulse. Dr Ercole came from Cambridge. This is obviously all at a very early stage in the project but the active willingness of both Oxford and Cambridge Trauma care clinicians to share resources for the project is a very necessary step. We are still in the process to analyse the outputs of this meeting. |
Impact | This mutli-disciplinary exchange has so far discussed how knowledge of anaesthesia and TBI in a clinical urgent care environment can find relevance at the most fundamental level, i.e., the study of coupling between mechanics and electrophysiology at the cell level. So far only ideas have been exchanged. |
Start Year | 2016 |
Description | Traumatic Brain Injury Medical partners |
Organisation | John Radcliffe Hospital |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | The NeuroPulse project envisioned to establish the basis for a collaboration with both hospitals. I organised a few meetings to establish the foundations for NeuroPulse to develop clinically relevant outputs. A meeting was organised in Cambridge for the NeuroPulse academics to present their work. |
Collaborator Contribution | Another day meeting was organised in Oxford at the end of 2016 to discuss anaesthesia in the framework of NeuroPulse. Dr Ercole came from Cambridge. This is obviously all at a very early stage in the project but the active willingness of both Oxford and Cambridge Trauma care clinicians to share resources for the project is a very necessary step. We are still in the process to analyse the outputs of this meeting. |
Impact | This mutli-disciplinary exchange has so far discussed how knowledge of anaesthesia and TBI in a clinical urgent care environment can find relevance at the most fundamental level, i.e., the study of coupling between mechanics and electrophysiology at the cell level. So far only ideas have been exchanged. |
Start Year | 2016 |
Description | 1st Focused Ultrasound Neuromodulation workshop FUN2019, Oriel College, Oxford, UK (2019) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Created with two colleagues the: 1st Focused Ultrasound Neuromodulation workshop FUN2019, Oriel College, Oxford, UK (2019) |
Year(s) Of Engagement Activity | 2019 |
URL | https://fun.web.ox.ac.uk/ |
Description | Attendance at the 2nd POEM workshop on physics and excitatory membranes |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The sub title is "waves in Soft and Living Matter, their Transmission at the Synapse and their Cooperation in the Brain. Prof Jerusalem will participate in the round table discussions to report the work and findings of the Neuropulse project. |
Year(s) Of Engagement Activity | 2019 |
URL | http://med-bio.physik.tu-dortmund.de/cms/en/Home/POEM---Physics-of-excitable-membranes-2019/index.ht... |
Description | Conference: Society of Engineers 55th Annual Technical Meeting SES 2018 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Prof Jerusalem jointly Chaired Session IV - 5.4 on Thursday 11th October 2018, entitled "Mechanics of the Brain". |
Year(s) Of Engagement Activity | 2018 |
URL | http://ses2018.org/_medien/_content/files/abstract_booklet.pdf?t=124654353241 |
Description | EPSRC's Inaugural Healthcare Tehcnologies Hive Event |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | This will be an unique opportunity for you to meet and network with all the key grant holders in our Healthcare Technologies theme through a facilitated 2 day event. When we go out and about, the main observations we have is that there is never enough time to talk to other fellow academics and the networking part of any event always scores the highest mark. Therefore we have responded and we have invited 130 academics - all our programme grant holders, CDT directors, other leads in our large investments, our early career fellows, HTCAs and leaders of our network grants. The response rate has been really good with over 85% of those invited saying yes. The event will start at 10 am on the Tuesday and finish at 4pm on the Wednesday. We have experienced facilitators working with us and we are just finalising the details of the agenda. We have a dinner speaker and there will be an opportunity for you all in groups to discuss real challenges given by some charities with seedcorn money for the best proposals for further development of their ideas. I think you will find it extreme beneficial and be like the 2 day event we have for the HTCAs - you will also meet our new 8 HTCAs too. |
Year(s) Of Engagement Activity | 2017 |
Description | Invited Talk - Industrial and Interdisciplinary workshop, Mathematical Institute, University of Oxford |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation entitled " Mechano-electrophysiological, cognitive and computational challenges" to an audience that included industrialists and also researchers and from other departments. Information about Neuropulse and its wide range of potential applications was disseminated to this diverse audience. |
Year(s) Of Engagement Activity | 2019 |
Description | Invited talk - Columbia University Mechanical Engineering Seminar Series |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | A. Jérusalem. Computational brain multiphysics. Invited talk - Columbia University Mechanical Engineering Seminar Series, Columbia University, New York, NY, USA (2019) |
Year(s) Of Engagement Activity | 2019 |
Description | Invited talk - Marseille, France |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation entitled "Head injury simulations, cognitive and computational challenges" at the iLabSpine Science Day in Marseille, France |
Year(s) Of Engagement Activity | 2018 |
Description | Invited talk - Strasbourg, France |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Presentation entitled "Computational mutiphysics of brain trauma" at the "Festival de conférences ERC", Université of Strasbourg/Neuropôle, Strasbourg, France |
Year(s) Of Engagement Activity | 2018 |
URL | http://neuropole.u-strasbg.fr/ |
Description | MEP-Scientist Pairing Scheme 2017 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | EU parliament, MEP - Scientist Pairing Scheme 2017. MEP was Eva Kaili. The MEP-Scientist Pairing Scheme aims at enhancing mutual understanding and establishing a long-term, intensive cooperation between Members and researchers. STOA is currently organising the project for the 6th time. During their time at the European Parliament, the paired scientists will learn about the work of EP committees and research services, and will shadow their MEP counterparts in their daily activities. This aspect of the scheme is vital for both sides to identify the areas where the partners' knowledge and experience can be combined to feed into better legislation. Follow-up visits for MEPs to see their paired scientists at work will hopefully be agreed bilaterally during the scientists' visit to Brussels. |
Year(s) Of Engagement Activity | 2017 |
Description | Paper presented at European Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Joint paper entitled "Computational model of the mechano-electrophysiological coupling in axons with application to neuromodulation" presented at the 6th European Conference on Computational Mechanics, 7th European Conference on Computational Fluid Dynamics ECCM ECFD 2018, Glasgow, UK |
Year(s) Of Engagement Activity | 2018 |
URL | http://www.eccomas.org/vnews/1042/eccm-ecfd-conferences-2018- |
Description | Paper presented at European Conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Joint paper entitled "Cognition based bTBI mechanistic criteria; an in silico tool for preventive and therapeutic innovations" presented at the 6th European Conference on Computational Mechanics, 7th European Conference on Computational Fluid Dynamics ECCM ECFD 2018, Glasgow, UK |
Year(s) Of Engagement Activity | 2018 |
URL | http://www.eccomas.org/vnews/1042/eccm-ecfd-conferences-2018- |
Description | Paper presented at a Conference, St Andrews, UK |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Joint paper entitled "A viscous-hyperelastic constitutive model for transverse isotropic soft tissues" presented at the 60th British Applied Mathematics Colloquium BAMC2018, University of St Andrews, St Andrews, UK |
Year(s) Of Engagement Activity | 2018 |
URL | http://www.mcs.st-and.ac.uk/~bamc2018/ |
Description | Paper presented at workshop |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Joint paper entitled "Cognition based bTBI mechanistic criteria; an in silico tool for preventive and therapeutic innovations" presented at the 5th Oxford Workshop on Neuron and Brain Mechanics, University of Oxford, Oxford, UK |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.evensi.uk/5th-oxford-international-workshop-neuron-brain-mechanics-st-hughs-college/2429... |
Description | Paper presented to European Conference, Glasgow |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Joint paper entitled "OxFEMM, a scalable coupled Finite Element-Meshless Method program" presented at the 6th European Conference on Computational Mechanics, 7th European Conference on Computational Fluid Dynamics ECCM ECFD 2018, Glasgow, UK |
Year(s) Of Engagement Activity | 2018 |
URL | http://www.eccomas.org/vnews/1042/eccm-ecfd-conferences-2018- |
Description | Paper presented to European Conference, Glasgow |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Joint paper entitled "Mechano-electrophysiological model for nerve tissue in TBI and SCI" presented to the 6th European Conference on Computational Mechanics, 7th European Conference on Computational Fluid Dynamics ECCM ECFD 2018, Glasgow, UK |
Year(s) Of Engagement Activity | 2018 |
URL | http://www.eccomas.org/vnews/1042/eccm-ecfd-conferences-2018- |
Description | Paper presented to European Conference, Glasgow |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Joint paper entitled "A mechanical-electrophysiological membrane model for axonopathy. 6th European Conference on Computational Mechanics, 7th European Conference on Computational Fluid Dynamics ECCM ECFD 2018", Glasgow, UK |
Year(s) Of Engagement Activity | 2018 |
URL | http://www.eccomas.org/vnews/1042/eccm-ecfd-conferences-2018- |
Description | Paper presented to European Conference, Glasgow |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Joint paper entitled "Machine learning enhanced scalable finite element simulation of head injury" presented at the 6th European Conference on Computational Mechanics, 7th European Conference on Computational Fluid Dynamics ECCM ECFD |
Year(s) Of Engagement Activity | 2018 |
URL | http://www.eccomas.org/vnews/1042/eccm-ecfd-conferences-2018- |
Description | Presentation at international conference, Madrid, Spain |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Joint presentation with D Garcia-Gonzalez entitled "Numerical modelling of mechanics and electrophysiology in TBI" at the Society of Engineering's 55th Annual Technical Meeting - SES 2018. "Session V - 5.4 - Mechanics of the Brain" on Thursday 11th Oct 2018 |
Year(s) Of Engagement Activity | 2018 |
URL | http://ses2018.org/_medien/_content/files/abstract_booklet.pdf?t=124654353241 |
Description | Presentation at the Society of Engineering's 55th Annual Technical Meeting SES 2018 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Co-author of a paper entitled "MRI/MRA based in silico head model for stroke simulation" presented during Session VI - 5.4 "Mechanics of the Brain" on Friday 12th Oct 2018 |
Year(s) Of Engagement Activity | 2018 |
URL | http://ses2018.org/_medien/_content/files/abstract_booklet.pdf?t=124654353241 |
Description | Talk at 1st Focused Ultrasound Neuromodulation workshop FUN201 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | A. Jérusalem. Computational modelling of electromechanical coupling in the brain; implications for ultrasound neuromodulation. 1st Focused Ultrasound Neuromodulation workshop FUN2019, Oriel College, Oxford, UK (2019) |
Year(s) Of Engagement Activity | 2019 |
Description | Talk at National Gallery, London |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | A panel discussion on bringing basic research to entrepreneurship sponsored by Caixa Bank |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.caixabank.com/comunicacion/noticia/caixabank-brings-together-in-london-women-who-invest-... |
Description | Young Scientists Science Communication Module (London) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Undergraduate students |
Results and Impact | Prof Jerusalem will be attending this event on 26th March to engage with your scientists and answer questions. He will explain his background, the Neurpoulse project to them and how he communicates his scientific results. The two primary aims are firstly to stimulate interest in Neuropulse and his area of work, and secondly to assist young scientists maximise the way in which they communicate their results. |
Year(s) Of Engagement Activity | 2019 |