A hub for device personalisation in the treatment of congenital diseases

Lead Research Organisation: University College London
Department Name: Institute of Cardiovascular Science

Abstract

Between two and five babies in 100 are born with some defects that may require medical interventions. Clinical treatment of physical abnormalities often involves invasive surgery, which can be associated with serious complications, long stays in intensive care, prolonged hospitalisation, and even death. As devices and tools purposefully designed for treating children born with these defects are rare, clinicians often have to make do, adapting adult devices to the child's body. This is due to the small size of the paediatric market compared to the adult population market, but also, more importantly, to the huge variations that are encountered in birth defects compared to the adult world. Children born with the same syndrome present many different shapes and sizes of their physical defect. It is clear that in these cases, and unlike treatment of the elderly, one device cannot fit all.

More effort should be put into the development of new methods and technologies to create suitable devices for paediatric patients. These should be customisable for each individual patient in order to offer the best and safest treatment. Personalisation and bespoke devices are already commonly available in people's life: glasses, dental crowns, foot insoles. Customisation should be even more important and should play a critical role, when the device itself can make the difference between life and death. However, the cost and time demand of their production cannot be met by the biomedical industry, as the research efforts to test each device safety and efficacy are too high. In addition, the bioengineering industry does not have sufficient clinical knowledge and the understanding of different childhood diseases to develop such devices.

I am an engineer by training, but I have spent the last 10 years at Great Ormond Street Hospital for Children, a recognised world-leading children's hospital and the UK's largest paediatric centre. Here I have gained important knowledge of the clinical environment, birth defects and current clinical treatments. I have good understanding of the engineering technologies and work in close collaboration with the Mechanical Engineering Department (Dr Gaetano Burriesci) for all aspects related to device development and testing. In this project, I am proposing to work as a link between engineers and clinicians, university and industry, to drive the development of bespoke devices and tailored therapies for children and young adults born with physical defects.

I plan to use engineering methods and computer virtual reality to study the shape of the patient defects, and design new devices that can be easily tailored to individual need, on demand. I will create computer models of the defects, as well as virtual simulations to enable development of devices tailored to the specific anatomy of each patient. By studying the interaction between the site where the device is placed and the device itself, it will be possible to determine design changes, and predict device success or failure before the actual implantation, with no need for animal and bench experiments.
The methods I develop during this research project would be applicable to many different devices and technologies designed for treating children in the future. This may ultimately lead to significant reductions in both the number of manufactured prototypes (which will reduce cost of developing new technology) and the number of animal experiments in research work. Furthermore, device failure and other problems are expected to decrease, as we would be practising on patient-specific models before the real procedure, for the first time anticipating problems and adjusting accordingly to avoid them.

Planned Impact

Biomedical engineers working within this project will be exposed to the day-to-day clinical problems routinely encountered in the paediatric setting, to fully understand the wide range of anatomy and function present in congenital disease patients and the challenges that clinicians face in their treatment. This will enable them to focus and adapt their technical engineering skills to effectively help solve these problems.

Paediatric clinicians at GOSH will benefit from this project in the short-term as they will become more aware of the already available engineering technologies that could help improve their clinical practice and will get easier access to some of these technologies in house. In addition, in the long-term, a wider range of devices and tools for paediatric interventions will become available for clinicians not only from GOSH, but also from other Centres. The currently limited development of paediatric devices means that clinicians have to make do; they engineer solutions adapting available adult devices and tools, and face the extra challenges that come with such options that are not purposely designed for the child, resulting in higher risks for patients, longer operating time and suboptimal outcomes.

If the computational modelling framework developed for device customisation is proven successful, the national and international regulatory bodies may decide to change the way medical devices are approved by introducing patient-specific in silico clinical trials to shorten the pathway from bench to bedside.

The Healthcare system will ultimately be able to reduce the costs associated with the care of patients that cannot currently benefit from minimally-invasive interventions, by reducing long operating times secondary to ill-fitting devices and tools, and reducing long hospital stays due to high procedural risks and complications.

New device technologies will be developed that may find broader applications and interest from the biomedical device industry. The introduction of relevant and validated computational modelling in the device design and approval process would cut down the expenses of many failing prototypes, and reduce animal and bench experiments during the product development process.

Ultimately, this programme of work could be beneficial for the children and young adults born with anatomical defects, thanks to the availability of customised devices, more insightful planning of the surgery and interventions, thus potentially expanding the number of patients suitable for minimally-invasive treatments.

Publications

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Ajami S (2022) Mechanical and morphological properties of parietal bone in patients with sagittal craniosynostosis. in Journal of the mechanical behavior of biomedical materials

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Angullia F (2020) A novel RBF-based predictive tool for facial distraction surgery in growing children with syndromic craniosynostosis. in International journal of computer assisted radiology and surgery

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Beaumont CAA (2017) Three-dimensional surface scanners compared with standard anthropometric measurements for head shape. in Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

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Borghi A (2018) Spring assisted cranioplasty: A patient specific computational model. in Medical engineering & physics

 
Title Under the Microscope - Making the Invisible Visible - Sofie Layton 
Description A series of multidisciplinary artworks about the heart, including textile panels, 3D medical heart prints, and sculptures that translate some medical aspects of cardiology. Created in conversation with the cardiovascular imaging team, clinicians, parents and patients on Bear Cardiac Ward, young adults attending transition clinic and their parents. UCL Institute of Child Health, Winter Garden Gallery Space 
Type Of Art Artistic/Creative Exhibition 
Year Produced 2016 
Impact
URL http://sofielayton.co.uk/installations.41.html
 
Description Avicenna Alliance
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
 
Description ENRICHMENT in silico TRIAL Scientific Advisory Committee
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
URL http://www.3ds.com/newsroom/press-releases/dassault-systemes-and-fda-extend-collaboration-inform-car...
 
Description 3D CArdiac models For Education for La Fondation Dassault Systemes
Amount € 3,014,805 (EUR)
Organisation La Fondation Dassault Systèmes 
Sector Charity/Non Profit
Country France
Start 04/2018 
End 01/2019
 
Description BHF Project Grant "3D printing congenital heart disease: Assessing clinical translation for clinical practice, surgeon training, education and patient understanding"
Amount £206,476 (GBP)
Funding ID PG/16/99/32572 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2017 
End 05/2020
 
Description BHF Project Grant - Large-scale validation of computer simulations for personalised cardiovascular treatments in congenital heart disease
Amount £183,422 (GBP)
Funding ID PG/17/6/32797 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2017 
End 05/2020
 
Description ERC Starting Grant
Amount € 1,500,000 (EUR)
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 03/2018 
End 02/2023
 
Description FaceValue2
Amount £266,004 (GBP)
Organisation Great Ormond Street Hospital Children's Charity (GOSHCC) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2018 
End 01/2020
 
Description GOSCC - Face Value2: Improving clinic outcomes for children with syndromic craniosynostosis and related congenital anomalies
Amount £266,004 (GBP)
Organisation Great Ormond Street Hospital Children's Charity (GOSHCC) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2018 
End 06/2021
 
Description GOSCC - Improving surgical outcomes in Craniofacial surgery by means of biofidelic 3D printed digital materials replicating paediatric skull cranial bone mechanics
Amount £99,673 (GBP)
Organisation Great Ormond Street Hospital Children's Charity (GOSHCC) 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2019 
End 11/2020
 
Description GOSCC - Transforming imagination into reality with 3D technology
Amount £170,782 (GBP)
Organisation Great Ormond Street Hospital Children's Charity (GOSHCC) 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2017 
End 09/2018
 
Description NIHR Imperial BRC Imaging Theme
Amount £50,870 (GBP)
Organisation Imperial College London 
Department Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 03/2018 
End 03/2020
 
Description Research Training Fellowship - Emilie Sauvage
Amount £240,000 (GBP)
Funding ID 2572 
Organisation Action Medical Research 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2017 
End 08/2020
 
Description SIMCOR - In silico testing and validation of cardiovascular implantable devices
Amount € 7,260,000 (EUR)
Funding ID 101017578 
Organisation European Commission H2020 
Sector Public
Country Belgium
Start 01/2021 
End 12/2023
 
Description V-heaRts: Virtual Reality to enhance understanding, education and treatments of heart diseases
Amount £36,530 (GBP)
Organisation La Fondation Dassault Systèmes 
Sector Charity/Non Profit
Country France
Start 08/2019 
End 08/2020
 
Title FE-SPH simulation of the moving left heart 
Description Development of a method to incorporate patient specific ventricular motion into fluid-structure interaction simulations of the left heart and mitral valve 
Type Of Material Improvements to research infrastructure 
Year Produced 2017 
Provided To Others? No  
Impact Possibility of having a realistic setting to perform in-silico testing and optimisation of any mitral valve device and/or surgical strategy. 
 
Title Mitral valve automatic segmentation method for 3D echocardiography images 
Description Automatic method for the segmentation of mitral valve for 3D echocardiography images 
Type Of Material Improvements to research infrastructure 
Year Produced 2018 
Provided To Others? No  
Impact Speed up the process of medical image segmentation avoiding manual user input and operator specific bias 
 
Title 3D skull 0-4 years 
Description 3D shape model of the human skull in a healthy paediatric population (0-4 years old) constructed using a generative statistical shape model. 
Type Of Material Computer model/algorithm 
Year Produced 2021 
Provided To Others? Yes  
Impact not yet 
URL https://pubmed.ncbi.nlm.nih.gov/34917697/
 
Title FE-SPH simulation of the moving left heart 
Description Development of a method to incorporate patient specific ventricular motion into fluid-structure interaction simulations of the left heart and mitral valve using commercial software ABAQUS 
Type Of Material Computer model/algorithm 
Year Produced 2017 
Provided To Others? No  
Impact Possibility of having a realistic setting to perform in-silico testing and optimisation of any mitral valve device and/or surgical strategy. 
 
Title LSFM 
Description LSFM is the largest-scale 3D Morphable Model (3DMM) of facial shapes ever constructed, based on a dataset of around 10,000 distinct facial identities from a huge range of gender, age and ethnicity combinations. This model has been built using an especially-designed, fully automated system that accurately establishes dense correspondences among 3D facial scans and is robust to the large shape variability exhibited in human faces. LSFM includes not only a global 3DMM model but also models tailored for specific age, gender or ethnicity groups. This was made possible thanks to the extremely rich demographic information that the used dataset has. LSFM is built from two orders of magnitude more identity variation than current state-of-the-art models. Extensive experimental evaluations (Booth et al., CVPR'16) have shown that this additional training data leads to significant improvements in the characteristics of the statistical modelling of the 3D shape of human faces, and demonstrate that LSFM outperforms existing state-of-the-art models by a wide margin. 
Type Of Material Computer model/algorithm 
Year Produced 2019 
Provided To Others? Yes  
Impact >100 research groups downloaded the model and 2 large software companies have expressed interest in buying the model 
 
Title Mitral valve automatic segmentation method for 3D echocardiography images 
Description Automatic method for the segmentation of mitral valve for 3D echocardiography images 
Type Of Material Data analysis technique 
Year Produced 2018 
Provided To Others? No  
Impact Speed up the process of medical image segmentation avoiding manual user input and operator specific bias 
 
Title library of 3D cardiovascular models 
Description database of 3D surface reconstructions of hearts from healthy volunteers, congenital heart disease patients and adults with structural heart disease 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact towards the design of in-silico clinical trails 
URL http://www.ucl.ac.uk/cardiac-engineering/research/library-of-3d-anatomies
 
Title statistical shape analysis to investigate ventricular shape and motion 
Description Implementation of a image-based computational method for the statistical shape and motion analysis of cardiac images. 
Type Of Material Data analysis technique 
Year Produced 2017 
Provided To Others? Yes  
Impact Method published in a Journal paper (Frontier in Paediatrics Cardiology, February 2017) 
 
Description CNR - Italian National Research Centre 
Organisation National Research Council
Department IENI ICMATE
Country Italy 
Sector Public 
PI Contribution Exchange of ideas about the use of biodegradable alloys in craniofacial surgery - production of grant proposals Dr Borghi successfully applied for BRC ATSMTD funding (£28K). The (ongoing) project will use the current expertise in craniofacial device design and simulation to produce a novel distractor for the treatment of unicoronal craniosynostosis. The preliminary work has been finalised by a visiting student and an abstract has been submitted to the European Society of Biomechanics. Dr Borghi has applied for a Wellcome Trust grant (unsuccessfully) and is currently re-drafting for another submission.
Collaborator Contribution Exchange of ideas about the use of biodegradable alloys in craniofacial surgery - production of grant proposals CNR staff (Dr Carlo Biffi) has contributed grant applications (BRC, Wellcome) and has provided important technical insight CNR has provided FeMn and stainless steel samples for biodegradation testing. Tests are ongoing and will be ready within 2 months for further discussion and dissemination
Impact A grant was awarded (BRC), a grant proposal was produced and is being redrafted.
Start Year 2020
 
Description CVD Hub TAVI 
Organisation Barts Health NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution Data image processing and research inputs
Collaborator Contribution Patient data and clinical expertise
Impact this collaboration has just been established
Start Year 2020
 
Description Chest implant 
Organisation Great Ormond Street Hospital (GOSH)
Country United Kingdom 
Sector Hospitals 
PI Contribution We are designing and manufacturing a bespoken implant for a patient with severely asymmetric chest. The patient had his pectoralis major removed as a child and his chest has subsequently developed asymmetrically. CT data has been post-processed and a subcutaneous implant has been designed, which should improve chest symmetry. Prototypes have been created using 3D printing techniques and tested on top of the patient's chest. A silicone cast is now underway for the final implant, which will be sterilised and implanted in the next few weeks.
Collaborator Contribution Clinical information
Impact multidisciplinary: biomedical engineering from FaceValue and clinical inputs from GOSH Plastic Surgery
Start Year 2014
 
Description Collaboration with FDA/Dassault Systemes - ENRICHMENT 
Organisation Dassault Systemes UK Ltd
Country United Kingdom 
Sector Private 
PI Contribution An in silico clinical trial is underway with the 3DEXPERIENCE platform to evaluate the Living Heart simulated 3D heart for transforming how new devices can be tested I am the keader of the WP dedicated to the creation of Virtual Populations
Collaborator Contribution Both Dassault Systèmes and the FDA recognize the transformative impact of modeling and simulation on public health and patient safety
Impact Not available yet
Start Year 2020
 
Description Collaboration with FDA/Dassault Systemes - ENRICHMENT 
Organisation Food and Drug Administration (FDA)
Country United States 
Sector Public 
PI Contribution An in silico clinical trial is underway with the 3DEXPERIENCE platform to evaluate the Living Heart simulated 3D heart for transforming how new devices can be tested I am the keader of the WP dedicated to the creation of Virtual Populations
Collaborator Contribution Both Dassault Systèmes and the FDA recognize the transformative impact of modeling and simulation on public health and patient safety
Impact Not available yet
Start Year 2020
 
Description Craniofacial Rotterdam 
Organisation Erasmus University Rotterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Orthopantomogram (OPG) is routinely used for assessing mandibular and maxillary pathologies, such as Hemifacial Microsomia. Orthopantomogram (also known as panoramic radiograph) is a panoramic scanning dental x-ray technique: it has low radiation levels but is affected by distortions. Cone Beam Computed Tomography (CBCT) is a tomographic technique providing full 3D models of the mandible and maxilla. It is not routinely used due to the high level of radiations the patients receive, but provides information for full 3D reconstruction. A project of comparison between the information from OPG and CBCT is underway and initial results have highlighted areas of highest distortion in OPG. Further work will use population data on mandibular shape to attempt conversion of 2D shape (from OPG) to 3D. This would allow us to use information from OPG, more widely adopted to follow-up patients due to the lower radiation dose, in order to better assess the distraction process over time. Orbital graft resorption (in collaboration with Maarten Koudstaal) In case of orbital trauma, autologous bone is used to repair the orbital floor. Such graft undergoes reabsorption over time, compromising the quality of the repair. CT images of 20 patients having undergone orbital floor repair using iliac grafts were analysed to assess the amount of reabsorption. For each patient, two sets of images were post-processed: The CT scan immediate post graft implantation and the scan acquired at 1-year follow-up. 3D volumes of the orbital region were reconstructed and difference in bone volume between the two scans was compared. Preliminary results show high reabsorption (over 80%).
Collaborator Contribution Dr Maarten Koudstaal spends a week every month working at GOSH.
Impact multidisciplinary: biomedical engineering expertise from GOSH and clinical expertise and data from Erasmum
Start Year 2013
 
Description Department of Maxillofacial Surgery - S. Orsola Malpighi (BO) 
Organisation Ospedale S Orsola- Malpighi, Bologna
Country Italy 
Sector Hospitals 
PI Contribution Research Collaboration through data and expertise exchange
Collaborator Contribution Research Collaboration through data and expertise exchange
Impact 10.1371/journal.pone.0197209 - published 10.1007/s10237-019-01229 - pubslished 10.1016/j.jpra.2019.05.002 - published Another 2 papers in preparation
Start Year 2018
 
Description Fetal faces 
Organisation Queen Charlotte's and Chelsea Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Quantitative analysis of fetal facial morphology using 3D ultrasound and statistical shape modelling Image analysis and statistical shape modelling
Collaborator Contribution Fetal face ultrasound images and clinical expertise
Impact http://dx.doi.org/10.1016/j.ajog.2017.02.007
Start Year 2015
 
Description Finite element analysis of mandibular distraction in Craniofacial Microsomia 
Organisation Boston Children's Hospital
Country United States 
Sector Hospitals 
PI Contribution This project was done in collaboration with the department of Oral and Plastic Surgery: Alessandro Borghi, senior research associate spent 3 months there to analyse data from the craniofacial microsomia database and produce 3D models of mandibles, which were used for numerical modeling of mandibular distraction in patient specific conditions.
Collaborator Contribution Dr Padwa, head of oral surgery of the dept of Oral and Plastic Surgery, provided clinical expertise and allowed access to retrospective patient data.
Impact The partnership is still ongoing. the work is being finalised and will soon be ready for dissemination. The results show geometrical effect of patient anatomy on ossifcation of mandible during distraction. This collaboration is a joint venture of engineering and clinical expertise,
Start Year 2015
 
Description Living Heart Project 
Organisation Semelab Plc
Country United Kingdom 
Sector Private 
PI Contribution The project unites leading cardiovascular researchers and educators with medical device manufacturers, regulatory agencies, and practising cardiologists on a project to develop and validate a personalised digital human heart model for cardiovascular in silico medicine. I am a Project Member since its foundation. A PhD student from our group (Giorgia Bosi) is currently spending 3 months in their offices to work on the personalisation and validation of this model.
Collaborator Contribution Development of the computational model platform
Impact multi-disciplinary
Start Year 2014
 
Description Mechanical Engineering, UCL 
Organisation University College London
Department Mechanical Engineering
Country United Kingdom 
Sector Academic/University 
PI Contribution Experimental tests to evaluate friction of stents against biological tissue. Experimental test to assess material properties of balloons and rapid prototyping materials.
Collaborator Contribution Support in experimental equipment employment and support in the design of the experimental set up.
Impact Two papers have been submitted for publication.
Start Year 2013
 
Description Necker Hospital Craniofacial 
Organisation Necker-Enfants Malades Hospital
Country France 
Sector Hospitals 
PI Contribution Sharing of research methods and expertise
Collaborator Contribution Sharing of research methods, expertise and data
Impact multidisciplinary collaobration involving craniofacial surgeons, biomedical engineers and computer scientists
Start Year 2019
 
Description Padova 
Organisation University of Padova
Country Italy 
Sector Academic/University 
PI Contribution Processing of 3D echocardiography images for the segmentation of mitral valve
Collaborator Contribution Providing anonymised 3D echocardiography images of patients undergoing mitral chordae replacement for us to process.
Impact Ongoing collaboration. 2 abstracts submitted to the 2018 american association for thoracic surgery congress
Start Year 2017
 
Description Partnership with Dassauls Systemes for development of In Silico Clinical Trial 
Organisation Dassault Systemes UK Ltd
Country United Kingdom 
Sector Private 
PI Contribution An in silico clinical trial is underway with the 3DEXPERIENCE platform to evaluate the Living Heart simulated 3D heart for transforming how new devices can be tested. this is in collaboration with FDA. The Project aims to demonstrate the value proposition of computational modeling and simulation for new medical products: reducing from "years to days" the time from inception to testing in humans, providing quicker patient access to new treatments, reducing overall risk and performance uncertainty, and maintaining or enhancing quality and public safety. Our team is part of the Scientific Council
Collaborator Contribution Engaging with regulatory body. Resources shared
Impact The working group was established in 2019 and a kick off meeting was held last February. a document will be released in the next months
Start Year 2019
 
Description RFH 
Organisation Royal Free Hospital
Department Department of Cardiology
Country United Kingdom 
Sector Hospitals 
PI Contribution protocol design and image analysis
Collaborator Contribution clinical expertise on mitral valve dysfunction, patient images
Impact multidisciplinary involving engineers and cardiologists
Start Year 2016
 
Description Rajiv Chaturvedi | SickKids 
Organisation The Hospital for Sick Children (SickKids)
Department Department of Paediatric Cardiology
Country Canada 
Sector Hospitals 
PI Contribution Development of methodology to study RVOT 3D anatomy in longitudinal ToF patients
Collaborator Contribution contribution with patient data and clinical expertise
Impact multidisciplinary with clinical collaborators from SickKids and engineering groups in UCL
Start Year 2021
 
Description Ultrasound phantoms, Adrien Desjardins 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Anatomically realistic ultrasound phantoms using gel wax with 3D printed moulds. 3D files of heart reconstruction
Collaborator Contribution ultrasound methodologies
Impact submitted manuscript
Start Year 2016
 
Description i-bug - Normal morphometric 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Dataset of more than 12,000 high-resolution 3D facial images, representing a wide range of age and ethnicity was collected in the London Science museum a couple of years ago. Creation of a set of homologous landmarks for semi-automatic representation of each face to establish dense correspondences. These will be used to build statistical models, for gender, ethnicity and age.
Collaborator Contribution Exploitation of the collected data and building of the first morphometric models that can robustly represent variations of normal values of different groups.
Impact multi-disciplinary involving clinical expertise from GOSH/ICH and i-bug expertise in image processing and computing
Start Year 2013
 
Description Biomedical Research Centre Family Fun Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Opportunity for the general public to take part in fun hands on activities and learn about the research at the National Institute for Health Research (NIHR) Great Ormond Street Hospital Biomedical Research Centre.
Year(s) Of Engagement Activity 2019
 
Description ENRICHMENT in silico TRIAL Scientific Advisory Committee 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact A newly formed partnership between FDA and 3DS with the primary role of providing guidance on modeling and simulation, verification, validation and uncertainty quantification, and statistical methodologies proposed and employed by the functional teams who are designing and executing the various aspects of the in silico clinical trial. Kickoff meeting on 28th February 2020 at the FDA.
Year(s) Of Engagement Activity 2020
 
Description Rare Disease Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Participation with a stand on VR and 3D printed models at a day workshop for patients, parents, carers and families to take part in fun hands on activities, meet researchers and discover how medical research is helping with treatments in congenital heart disease
Year(s) Of Engagement Activity 2019
 
Description Research Awareness Week at GOSH organised by GOSH UCL BRC 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Research trail with patients, parents visiting different research stations in the hospital
Year(s) Of Engagement Activity 2017
 
Description School Visit 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Presentation of my experience as a woman in STEAM at the Science Senior Society of the North London Collegiate School for girls
Year(s) Of Engagement Activity 2019
 
Description Two Brains, One Skull - Separating Conjoined Twins 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact BBC News Our World, a series on the separation of a set of craniopagus cojoined twins at Great Ormond Street Hospital, featuring the use of technology developed by the research team to suppport clinical decision making process and treatment.
Year(s) Of Engagement Activity 2019
 
Description interview for national news - VR sagittal case 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact BBC Click story on the use of our virtual reality platform and patient specific computational modelling to enhance informed consent for a family with a 6 month old baby undergoing surgery for saggital craniosynastosis.
Year(s) Of Engagement Activity 2021
URL https://www.bbc.co.uk/news/technology-59373963
 
Description interview for national news co-joined twins 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Separation of craniopagus cojoined twins using 3D printing and virtual reality technology for the planning of the complex stages of surgery,
Year(s) Of Engagement Activity 2019
URL https://www.bbc.co.uk/programmes/n3ct5tcr
 
Description press interview with La Repubblica 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Press interview with La Repubblica on the development and use of Virtual reality and computer modelling and simulations
Year(s) Of Engagement Activity 2021
URL https://www.repubblica.it/salute/2021/01/11/news/la_realta_virtuale_per_curare_il_cuore_dei_bambini_...