Antimicrobial filters for hospital air and water systems

Lead Research Organisation: University of Hertfordshire
Department Name: School of Engineering and Technology

Abstract

Most of the world's population is now living in cities and travelling more. As a result we are more likely to come into contact with infections that we would not have been exposed to just a few decades ago due to interactions with more people. The environment plays an important role in the transmission of some infections and it is possible to reduce the transmission of such disease by better filtration of water and air. Some filtration systems are currently used which physically stop pathogens such as bacteria. However these systems cannot stop virus particles, are expensive, require frequent maintenance and careful disposal.

The aim of this project is to design one air and one water filter which will actively kill bacteria and viruses, thereby reducing their numbers in the environment. These filters will require less maintenance and be inexpensive to produce. During the project, we will first test the antimicrobial effect of a variety of nanoparticles. These will then be modified chemically so that they can be incorporated into materials that are suitable for water and air filtration. The filters containing the antimicrobial nanoparticles will be produced using a new EPSRC funded spinning technology developed at UCL. Once we have produced the antimicrobial filtration materials, we will test their ability to kill viruses in air and bacteria in water. We will test filters with different concentrations of antimicrobial nanoparticles and with different depths. We will also make sure that the filters are effective at flow rates that are used in the real world.

The antimicrobial filters will be of most interest to the healthcare industry in the first instance, but they will also be relevant to busy public buildings (such as schools and care homes) and transport vehicles (such as airplanes). Furthermore, the filters will be capable of oxidising non-biological materials, like tar and pollution particulates and will improve air quality in a range of indoor environments. During the project we will be collaborating with industrial partners (including Pall Corporation, the world's biggest filtration company) and clinicians to ensure that we produce a viable product. At the end of the project, the technology will be validated and ready for scale-up production and we plan to apply for further funding for a collaborative project with industry in order to do this.

Publications

10 25 50
 
Title Antimicrobial nanoparticles could be used in personal facemask 
Description Face-masks could be as an artistic & creative facial product. 
Type Of Art Composition/Score 
Year Produced 2017 
Impact Antimicrobial face-mask will be useful in hospitals, public places and public transportation systems. It is particularly useful in flu pandemics. 
 
Description During 2017-18 we had centred our investigation on the dispersion process and optimisation of the selected multi-elemental nanoparticles or intermetallic nanoparticles. The key finding is that these optimised multi-elemental antimicrobial nanoparticles (OM-AMNP) generated enormous antiviral/antimicrobial potencies in comparison to other metal-based antimicrobial materials. Their standard viral and MIC bacterial test results not only showed an excellent synergistic efficacy (99.99%) against Flu viruses but also demonstrated significant bacterial killing effects (99.999% in MIC assay) against G(+-) bacteria, such as MRSA, A. Baumannii, K.pneumonia, P. aeruginosa, E.coli, and some of the fungus.
Importantly, These nanoparticles are still active even embedding in the gyration sub-micron fibres that aimed use in filtration pads for hospital operation theatres and other potential medical and healthcare applications. This key finding has been in-line with Antiviral Nanoparticles (AVNP) developed by the AVNP Consortium (led by QinetiQ, funded by DTI £3.2M) during 2005-10 in which the multi-elemental composition provided enhanced antiviral efficacy (viral killing rate reached 99.99%).
We have characterised the past antiviral and antimicrobial nanomaterials (AVNPs and AMNPs) using chemical and physical analytical facilities through EPSC provided analytical facilities in other universities, and the outcomes showed that AVNP made by plasma forming could give a much better-sustained dispersion in water (>2 hours before a total precipitation while pure nanoparticles would precipitate within 30min).
Other important factors have continuously been un-rolled that the AVNP nanoparticles contained only 3-6% metal alloy nanoparticles and wrapped by graphite or graphene sp2 layered structures, which enhanced designable lengthy suspension stability for the AVNP in water or silane while potentiated their antimicrobial performance tremendously.
Over the past 2.5 years, we have investigated over 18 standard alone nano-materials and 14 variations of antimicrobial nanoparticle formulations (AMNP2, AMNP8.1 and 9.1) that were composed of the customised ratio of silver, copper and zinc, etc. All standard alone nano-materials were structurally characterised using a combination of imaging and analytical techniques. We also analysed the precise chemical compositions and some of their physio-chemical behaviours in aqueous formation. In the processes, a volume of analytical results of the materials along with their corresponding antimicrobial studies has been collected in our research library for some future references.
During the extensive antimicrobial exploration of a range of nanomaterials, we also found some of the commercially available intermetallic alloy nanoparticles were particularly effective against Gram-negative bacteria which matched our hypothesis from the original proposal in which the engineered AVNP nano-intermetallic formulations played a critical role in the microbe inhibitions. Here, a super antimicrobial formation (AMNP8.1) was successfully created, along with its incorporation into the polymeric fibre using the gyration process. Both products (AVNP/AMNP8.1) were proofed to effectively kill (> 98-99.99%) against two targeted Gram+/- bacteria (Pseudomonas aeruginosa and Staphylococcus aureus) commonly found in Great Ormond Street Children's Hospital. Scale-up production trails of these super-formulated antimicrobial filters have been routinely carried out with the analytical methods established by the team member to monitor and validate the quality of the gyration fibre pads produced for both water and air filtrations.
Also, leaching analysis has also proven to be within a standard safety threshold of ionic concentration in a real application of the water system.
Although the majority of the objectives has been achieved, the AMNP8.1- 9.1 (super formulation) assay against two proposed viruses (Adenovirus and Influenza A) are still under testing waiting for the results. The antiviral evaluation of the filtration system is expected to be completed in the summer of 2019 or before the end of the expanded award (July 2019).
Exploitation Route Our findings of multi-elemental metal alloy nanoparticles (namely AMNP8.1-8.2) are now chosen by the EPSRC AMF consortium as the key antimicrobial ingredients to be incorporated into the proposed filter pads. The AMNP incorporation processes for the filter pad fibres/fabrics has been fulfilled by a fast and low-cost gyration process developed by our UCL partners. The initial tests on the antimicrobial filters shown maximum 50-70% bacterial killing rates using the optimised antimicrobial nanoparticles. The first part of an antimicrobial study using AMNP 2 have already been published in 2017 (see references). Two of these nanoparticle formulations were found not only effective to bacteria but also be generically effective against other pathogenic viral-species (i.e. SARS coronavirus, Avian influenza virus (H5N1), Uukuniemi virus, Porcine reproductive and respiratory syndrome virus (PRRSV). We are particularly interested in the biological mechanisms and physiochemical interactions between the microbes and the nanoparticles. Cryogenic TEM images had been initially carried out by a collaborator from Oxford Biological Structure Imaging Centre, however more sophisticated biological assays are required to understand the in-deep philosophy and involvement in the microbe-killing and inhibition actions that occurred in our research.
Sectors Agriculture, Food and Drink,Chemicals,Environment,Healthcare,Leisure Activities, including Sports, Recreation and Tourism,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

URL http://researchprofiles.herts.ac.uk/portal/en/publications/characterisation-of-chemical-composition-and-structural-features-of-novel-antimicrobial-nanoparticles(181ca0b1-01c0-4bb5-a414-ff5cec6a40db).html
 
Description A number of the highly efficient antimicrobial filters has been assembled or produced by incorporating novel nanoparticle formulations into PMMA gyration fibres. Both nanoparticles and the gyration spun nanoparticle-polymer hybrid fibres showed excellent antimicrobial efficacy against pathogens commonly found in Great Ormond Street Children's Hospital, i.e. Staphylococcus aureus (a Gram-positive bacteria) and Pseudomonas aeruginosa (a Gram-negative bacteria). These experimental testing filters showed great potential for the antimicrobial filtration system that has proven suitable for the water filtration system as a first step progression. In addition to its feasible applications in both water and air filtration systems, our leaching study results suggested the antimicrobial nanoparticle formulations have extremely low leaching rate (e.g. < 3 ppm of concentration from the ions leached from nano-samples) in which the toxicity kept within the standard threshold limit (<8-10 ppm). In one word, the application of such antimicrobial filter would not affect the quality of with 1000 drinking water.
First Year Of Impact 2018
Sector Agriculture, Food and Drink,Chemicals,Construction,Environment,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology
Impact Types Societal

 
Title Antimicrobial formulation creations 
Description Seven novel Antimicrobial formulations (AMNP 1-7) were created using either the Tesima thermal plasma technology or high power ultrasonic dispersion method. These synthetic composites consisted of multi-elemental components (i.e. carbon, tungsten, copper and silver) in particle sizes ranging from 10 - 50 nm. Within these formulations, especially in the case of dispersing Silver particles in aqueous suspension, surface treatments were performed using diluted ammonium hydroxide. This treatment method was found highly efficient, additional 50 uL of diluted ammonium hydroxide solution (0.3%) totally dispersed 1% wt/v aqueous Silver after ultra power sonication. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact So far, these newly synthesized nanoparticle composites (AMNP 1-7) have proven to exhibit excellent antimicrobial effect in P. aeruginosa (Gram-ve bacteria). In particular AMNP4 and AMNP6 showed to reach 99.99% (log ratio) of killing rate at concentration 0.1 %. Preliminary data suggested that antimicrobial effect was enhanced by the presence of multi-elemental composites contained in these samples, the data also suggested high dosage of Silver particles is not necessary. An overview of the investigation implied optimal antimicrobial affects on particular microbes can be manipulated by applying the correct ratio of metals components in a formulation. The differentiation in metal ratio present in these formulations also implied a reduction of toxicity levels can be achieved, which has always been a major concern of using Silver nanoparticles in healthcare applications. 
 
Title Antimicrobial nanoparticles leaching study using ICP-OES 
Description Inductive Coupled Plasma equipped with optical emission spectrometer (ICP-OES) is a highly sensitive piece of equipment to detect, trace and quantify the presence of metal ions in liquid samples. This instrument can trace presence of heavy metal down to part per million scales (ppm). A very thorough method has now established by our research team to quantify concentrations of silver, copper and zinc ions that are saturated in aqueous supernatant formed by different nanoparticle suspensions. Our result has shown only 3 ppm (max.) of ion concentration was leached into the water solution when dispersed nanoparticle suspensions at a concentration of 1000 ppm were left standing at room temperature for 24 hours. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2017 
Provided To Others? Yes  
Impact This method is now developed as a standard leaching protocol for antimicrobial water filters that we are aiming to develop in the awarded project. The idea and method were presented in an international conference (Nanobio & Med 2017) with the title: "Structural characterisation of antimicrobial Copper oxides and its leaching study using inductively coupled plasma optical emission spectrometry (ICP-OES)" and it is published by Phantoms foundation. ISBN (Electronic) 978-84-697-7905-7, p. 156-157. 
URL http://www.nanobiomedconf.com/NBM17/Book.php
 
Title Automated nanoparticle dispersion process with spontaneous particle sizes measurement 
Description A computer controlled multi-channel mixer pump utilized with a high power sonicator probe, which is equipped with a nanoparticle tracking analyser. This comprehensive instrument allows different flow rate and variation of nanoparticle concentrations to be programmed. The resulting dispersion can be visualized at real-time using NTA. 
Type Of Material Technology assay or reagent 
Year Produced 2019 
Provided To Others? No  
Impact This piece of equipment schematically provide good demonstration to introduce Nanoparticle dispersion process. It had been illustrated in presentations and posters in various engagement events. 
 
Title Development of multi-scaled physical and chemical characterization mythologies for finding and optimization the best formulations of anitmicrobial nanoparticles for inhibiting microbes 
Description Characterization of chemical composition and structural features of novel antimicrobial nanoparticles: During the process, 3 antimicrobial nanoparticles (AMNP0-2^TesimaTM) were investigated using a combination of analytical methods: SEM/TEM, XRD, XPS, NMR, FTIR and Raman. 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact Once the results published, it will be possible to generate new activities on further characterization of the existing functional nanoparticles. 
 
Title Nanosight 
Description The instrument could observe some very important factors for nanoparticles biological application in terms of AMNP's particle size distribution, dispersion uniformity and concentration in the suspension, which are some of the vital information for the effectiveness of the bio-functions generated by nanoparticles. 
Type Of Material Biological samples 
Year Produced 2017 
Provided To Others? Yes  
Impact Will provide this useful tool for partners biological tests such as viral particles distribution and precipitation and precipitation ratio, and many other phenomenon, etc. 
 
Title Real-time nanoparticle tracking analysis (an advance sizing technology) using dynamic light scattering method 
Description A highly sensitive method to track nanoparticles and to measure their sizes together with their concentrations in suspensions using a Nanosight instrument by Malvern. Results generated using this instrument can be combined with analytical data obtained from the Zetasiser for parallel study. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2016 
Provided To Others? Yes  
Impact The majority of this technique is used for analysing organic components such as small drug molecules and proteins macromolecules to detect their sizes distributions and aggregation properties. However, this method is rarely used to analyse metallic based particles due to lack of method establishment. 
 
Title Ultra-sonication mixing process (continues and automated) 
Description To replace the conventional nanoparticle dispersing process using high power sonication probe standard alone, we have recently designed and developed an automated system, which allows a continues flow of nanoparticle suspension being dispersed under a cyclic and sealed environment. This system contains an LPGE unit with quadrant channel that allows switching of a maximum of four different starting materials to be mixed and subjected to the sonicating vessel. The flow gradient and overall mixing method, including time and rate of the circulation process, is fully automated, quantified and can be controlled by an equipped computer. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? No  
Impact Our preliminary study of forming nanoparticle suspensions using the conventional dispersing method suggested that a much more stable suspension can be formed under a prolonged period of ultrasonication process. Aggregation of particles in water suspension can be avoided when nano-samples were aggressively dispersed, however, using manual sonication method may cause harm to users due to high frequencies noises produced in the prolonged dispersion process. There are several advantages of introducing this newly developed sonication system, firstly, sonication process is performed in a sealed condition, therefore high frequencies generated during experiment would be massively reduced. The sealed vessel is made of stainless steel, and so it allows preservation of heat accumulation and limiting solvent to be evaporated, which often occurred in most of the open vessels. The advanced automated mixing system allows concentrations of various starting materials to be customized throughout the production process. This system also equipped with a two-way switch in between the mixer pump unit and seal vessel to ensure the pump units to be thoroughly cleaned by applying additional solvent. We are still in the process of validating this novel process, and if succeeded, methods will either be published as soon as possible. 
 
Description Antiviral nanoparticles and their biological functions 
Organisation Queen Mary University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution This is a collaboration developed for the antiviral nanoparticles applications towards prevention of animal infections by animal flu viruses in parallel to our EPSRC project in which we are adding antimicrobial nanoparticles to polymer fibers that can be used for filtration pads for antimicrobial.
Collaborator Contribution Pirbright Institute will provide testing facilities for antiviral tests for the AVNP materials. Prof John Oxford from Queen Mary Barts and the London will provide advance to the nano-particle test methodology and help to explore the applications.
Impact Some initial antiviral tests on our AVNP's showed excellent results and further tests are carried out for repeating. If everything is 100% confirmed, we will consider to put a proposal to BBSRC for further investigation which could be very very interesting and beneficial to our animal world.
Start Year 2016
 
Description Antiviral nanoparticles and their biological functions 
Organisation The Pirbright Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution This is a collaboration developed for the antiviral nanoparticles applications towards prevention of animal infections by animal flu viruses in parallel to our EPSRC project in which we are adding antimicrobial nanoparticles to polymer fibers that can be used for filtration pads for antimicrobial.
Collaborator Contribution Pirbright Institute will provide testing facilities for antiviral tests for the AVNP materials. Prof John Oxford from Queen Mary Barts and the London will provide advance to the nano-particle test methodology and help to explore the applications.
Impact Some initial antiviral tests on our AVNP's showed excellent results and further tests are carried out for repeating. If everything is 100% confirmed, we will consider to put a proposal to BBSRC for further investigation which could be very very interesting and beneficial to our animal world.
Start Year 2016
 
Description Biological evaluations of nanoparticles and their organic conjugates in the Central nervous system 
Organisation Nankai University
Country China 
Sector Academic/University 
PI Contribution Our research team provides selections of nanoparticles and other novel synthetic chemical compounds for biological assays.
Collaborator Contribution Our partners from Nankai University have been producing a large number of biological studies using nanomaterials and drug chemicals (tris- and bisphosphonates) we provided.
Impact Several papers have published (see publication list with the co-authors from Nankai University). Since then, some more articles were published using bisphosphonates for research as part of drug therapies for some of the neuronal degeneration diseases.
Start Year 2014
 
Description EPSRC AMF UCL project partner 1-3 
Organisation Great Ormond Street Hospital Children's Charity (GOSHCC)
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution The University of Hertfordshire provides antimicrobial research and experimental work to prepare the antimicrobial nanoparticles for incorporation into the polymer mats for hospital water and air filtration applications.
Collaborator Contribution UCL Engineering: To produce antimicrobial mats with above nanoparticles using a pressured gyration method. UCL Civil Env. Geo.: To test the antimicrobial efficacy of filtration mats and design prototypes of filtration systems. GOSH: Will test the filters in their hospital filtration system.
Impact First paper outcome: U. Eranka Illangakoon, S.Mahalingama, K.Wang, Y.-K. Cheong, E. Canales, G.G. Ren, E.Cloutman-Green, M. Edirisinghe?, L. Ciric (2016) 'Gyrospun antimicrobial nanoparticle loaded fibrous polymeric filters'. Materials Science and Engineering C 74 (2017) 315-324
Start Year 2016
 
Description EPSRC AMF UCL project partner 1-3 
Organisation University College London
Department Department of Civil, Environmental and Geomatic Engineering
Country United Kingdom 
Sector Academic/University 
PI Contribution The University of Hertfordshire provides antimicrobial research and experimental work to prepare the antimicrobial nanoparticles for incorporation into the polymer mats for hospital water and air filtration applications.
Collaborator Contribution UCL Engineering: To produce antimicrobial mats with above nanoparticles using a pressured gyration method. UCL Civil Env. Geo.: To test the antimicrobial efficacy of filtration mats and design prototypes of filtration systems. GOSH: Will test the filters in their hospital filtration system.
Impact First paper outcome: U. Eranka Illangakoon, S.Mahalingama, K.Wang, Y.-K. Cheong, E. Canales, G.G. Ren, E.Cloutman-Green, M. Edirisinghe?, L. Ciric (2016) 'Gyrospun antimicrobial nanoparticle loaded fibrous polymeric filters'. Materials Science and Engineering C 74 (2017) 315-324
Start Year 2016
 
Description EPSRC AMF UCL project partner 1-3 
Organisation University College London
Department Mechanical Engineering
Country United Kingdom 
Sector Academic/University 
PI Contribution The University of Hertfordshire provides antimicrobial research and experimental work to prepare the antimicrobial nanoparticles for incorporation into the polymer mats for hospital water and air filtration applications.
Collaborator Contribution UCL Engineering: To produce antimicrobial mats with above nanoparticles using a pressured gyration method. UCL Civil Env. Geo.: To test the antimicrobial efficacy of filtration mats and design prototypes of filtration systems. GOSH: Will test the filters in their hospital filtration system.
Impact First paper outcome: U. Eranka Illangakoon, S.Mahalingama, K.Wang, Y.-K. Cheong, E. Canales, G.G. Ren, E.Cloutman-Green, M. Edirisinghe?, L. Ciric (2016) 'Gyrospun antimicrobial nanoparticle loaded fibrous polymeric filters'. Materials Science and Engineering C 74 (2017) 315-324
Start Year 2016
 
Title New formulations of antimicrobial nanoparticles 
Description We are developing new formulations of nano-materials with multi-elemental combinations for more effective killing of microbes. However, we may need advice on possible protection or patent application. Also, our current work is drawn upon our previous patents on antiviral nanoparticles which were developed by the AVNP consortium sponsored by DTI during 2006-10. 
IP Reference  
Protection Protection not required
Year Protection Granted
Licensed No
Impact The new formulation will promote the filtration advances presumably for developing innovative antimicrobial filtration systems for hospital surgical centre applications. There are no antimicrobial filtration systems available for hospital applications.
 
Title Antimicrobial nanoparticles for water / air filtration systems for hospital applicatons 
Description The possible final applicable antimicrobial filtration device or system will be available in 1-2 years after this EPSRC project finishes. The current test results show lots of technical challenges in front of us. It has been proposed within the consortium that some more research in bacterial and viral killing mechanisms is urgently needed for further progression concerning the filtration formulation optimisation and product designs, etc. 
Type Health and Social Care Services
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2018
Development Status Under active development/distribution
Impact The hospital antimicrobial air and water filtration system will be very attractive to healthcare sectors and the research progress will be reported further in the due course. 
 
Description Antimicrobial filters for water and air 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact A short film was created by UCL and University of Hertfordshire, describing the production of antimicrobial fibers through the incorporation of antimicrobial nanoparticles to gyrospun fibre formation and the subsequent antimicrobial testings of the resulting products.
Year(s) Of Engagement Activity 2018
URL https://www.youtube.com/watch?v=A3Mqu74CG3w&list=PLNdejLwEhQrNm7zyw0htMll3zqiczyzh-&index=8&t=6s
 
Description Antimicrobial filters grant advisory panel meeting (every 3-6 months, UCL/UH) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact This meeting was held every 6 months during the period of our EPSRC grant, where we presented the latest research findings to the committees in our advisory panel. During these meetings we received advise from experts from different background including Hospitals, filter companies, material industries, etc.
Year(s) Of Engagement Activity 2016,2017,2018
 
Description Biomedical engineering symposium at Sheffield University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Third sector organisations
Results and Impact During this symposium, three presentations were delivered by our research team (Dr. G. Ren, Dr. Y.-K. Cheong and PhD student X. Yang). A number of new connections were made through networking with research leaders from different countries (China, South Korea, USA etc.). Large amount of research knowledge were exchanged throughout the two day event, potential collaborations were sought.
Year(s) Of Engagement Activity 2017
 
Description Conducted lecture with the title 'Introduction of Nanomaterials' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact The purpose of this undergraduate module is to provide an insight of what material engineering involved, as well as to promote the concept of nanoparticle applications.
Year(s) Of Engagement Activity 2015,2016
 
Description Internal School research seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Dr. Y. Cheong was invited to give a presentation in the departmental research seminar, which was organised by the School Engineering and Technology. This particular event is held on monthly basis with an aim to meet colleagues within the department as well as researcher from other departments within the University. A fifty minutes talk was delivered with the title 'Characterisation of Antimicrobial nanoparticles and their applications in biomedical engineering'. Interesting questions were asked, knowledges were exchanged and informal discussions were involved in a very friendly atmosphere. Internal collaboration was initiated with analytical chemist, Dr. J. Star and her team members in the School of life Sciences to investigate ion releases of the antimicrobial nanoparticles using ICP-OES. This collaborative work is held at the brand new Science building on site, these state-of-the-art facilities have also enabled us to widening our research scope in other medical divisions within the School.
Year(s) Of Engagement Activity 2016,2017
 
Description Material Research Exchange 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact The University of Hertfordshire had been allocated a stand/stall at the UK Advanced Materials Research Exchange & Investor Showcase 2018 (12-13, March 2018, Business Design Centre London) , where we displayed a number of posters for our EPSRC funded research projects, showcased our latest research findings from EPSRC to promote innovation, knowledge accumulation, and discuss potential collaborations and investments.
Year(s) Of Engagement Activity 2018
URL http://www.mre2018.co.uk/
 
Description Novel antimicrobial filters stakeholder event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact A stakeholder event was held at UCL, majority of the event was to promote the potential application of novel antimicrobial fibers that jointly developed by UCL and University of Hertfordshire. During the event, the Principle investigators from both UH and UCL presented research results as well as demonstrated the feasibility of incorporating super-antimicrobial nanoparticle formulations into fiber mats. Many questions were raised by policy makers and potential end users who attended the event. A web page were created as a record of this event and to promote antimicrobial filter applications.
Year(s) Of Engagement Activity 2018
URL https://mecheng.ucl.ac.uk/news/research-update-team-present-novel-antimicrobial-filters-developed-at...
 
Description Outreach 1: Attended the first conference/symposium in the field of nanomaterials biomedical applications 19-21 Feb 2017 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact YKC and GR recently invited to give talks to a symposium organised by Sheffield University, sponsored by British Council on their International Collaboration Project Funding (2 years, £120K) between 2015-17. Their funding was awarded to Dr B Chen on the collaboration among the UK, US and China.
The Symposium topic was 'Nanomaterials in biomedical applications' at University of Sheffield Led by Dr Biqiong Chen who is Senior Lecturer at the Department of Materials, University of Sheffield.
1. Dr Ren gave a presentation on "Antimicrobial Nanoparticles" and,.
2. Dr YK Cheong gave a presentation with the title 'Characterisations of antimicrobial nanoparticles'.
Audiences were from China, US, UK and EU.
The invited speaks were from UK universities and medical research organisation and hospitals and their counter parts from China, US and the EU.
Dr Chen's collaborators are Chinese Shanghai Jiaotong University, and US Michigan State University with funding from by British Council International Collaboration Programme (2016-18).
Year(s) Of Engagement Activity 2017
 
Description Pirbright Institute visit 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact The purpose of this meeting is to promote the applications of antimicrobial nanoparticles and their formulations. A number of participants found the topic we delivered interesting and we have successfully initiated a Msc project with couple of members at the Institute to study antimicrobial affects on animal viruses using antimicrobial formulations we provided.
Year(s) Of Engagement Activity 2016
 
Description Research meetings at UH (TARRC) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact We hosted a research meeting on-site with the director the Tun Abdul Razak Research Centre (TARRC) and two other of his colleagues to discuss potential collaborations in rubber processing. During this meeting, a few topics had been discussed including research and development of antimicrobial rubber and possible grant applications. We were invited to visit their industrial compound in the UK and conduct a talk for one of their seminar session.
Year(s) Of Engagement Activity 2017
URL http://www.tarrc.co.uk/
 
Description The Environment Network (Infection and disease prevention workshop) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Attended the annual Environment Net meeting at the Royal College of Paediatrics and child health London. The meeting was organised by EPSRC project partners at GOSH (Elaine Cloutman-Green). The purpose of this meeting is to gather groups of people who are interested in the role of the environment within infection control and disease prevention. This meeting consisted of a total of six talks delivered by experts with infection control knowledge in different background. The afternoon session consisted of workshops where groups of participants went through various case studies to investigate practical scenarios.
Year(s) Of Engagement Activity 2016,2017
URL https://www.participant.co.uk/participant/arrangement.aspx?id=195388&hash=0D4CA5856612AFDC110782B86A...
 
Description UH Engineering and computer sciences event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact A research seminar with the title 'Antimicrobial filters for hospital water and air systems' was delivered by both Dr G Ren and Dr Y-K Cheong. During this seminar, important messages about global concerns over antimicrobial resistant (AMR) was emphasized, research results obtained from antimicrobial nanomaterials were disseminated, the potential applications of antimicrobial filers were introduced. Over 25 audiences from various faculties/Schools from the University of Hertfordshire attended this seminar, positive feedback were well received.
Year(s) Of Engagement Activity 2019
 
Description UH Research meeting by inviting Prof. W. Bonfield (CBE, FRS, FREng, FMedSci), Emeritus Professor of Medical Materials, Cambridge University 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact During this meeting, we presented our work and promoted the application of antimicrobial nanoparticles to Prof. Bonfield who is a well-known Professor at the University of Cambridge. As outcomes of this meeting, Prof. Bonfield had a number of suggestions for our research development, introduced us some advanced testing methodology and possible and potential collaborative partners. Some proposed work had been initiated and potential grant applications are being discussed.
Year(s) Of Engagement Activity 2017