HETEROSTRUCTURE RADIATION DETECTOR MATERIALS FOR ADVANCED TIME OF FLIGHT POSITRON EMISSION TOMOGRAPHY (TOF-PET) IMAGING

Lead Research Organisation: Cranfield University
Department Name: Sch of Aerospace, Transport & Manufact

Abstract

This proposal aims at developing advanced radiation detector materials for Time of Flight Positron Emission Tomography (ToF-PET) imaging by exploiting the novel concept of high performance multi-material radiation sensing heterostructures. These heterostructures will contribute to the development of next generation imaging technologies for diagnostic, monitoring and therapeutic applications, specifically, by substantially improving the capabilities of ToF-PET technology. These heterostructures will enable i) enhanced diagnostic power; ii) reduced risk to patients (dose efficiency); iii) increased procedural flexibility (i.e. planning of radiation dose strategies and reduced examination time); and eventually iv) direct ToF-PET imaging by rendering the currently time-consuming post-acquisition reconstruction stage obsolete. This effort will be supported by multi-disciplinary facilitation of the design, fabrication and characterisation of the heterostructures, in order to develop an advanced detector material solution for use in current and future ToF-PET detector modules. The output and impact of the research will be maximised through functional testing of the proposed heterostructure detector module. The proposal matches the aspirations of the EPSRC's Healthcare Technologies research theme by i) optimising treatment and care through effective diagnosis, patient-specific prediction and evidence-based intervention; ii) supporting the development of technologies to enhance efficacy, minimise costs and reduce risk to patients; and iii) bringing together a multidisciplinary team with expertise in material science, precision engineering and instrumentation, who will be further supported by external advisors, ToF-PET experts and industrial partners for providing guidance and ensuring the transformational impact of the proposed effort.

Planned Impact

The resulting heterostructure, having multiple materials working in synergy, will have the potential to maintain a short attenuation length comparable to LSO while providing a usable part of its signal within a sub-nanosecond time range, a fundamental criterion for improving the CRT of ToF-PET scanners. Quantitatively, the proposal targets a decrease of the CRT down to about 50 or less ps full width half maximum (FWHM). This improvement will have tremendous implications for the ToF-PET capabilities and will initiate a virtuous circle with benefits involving, but not restricted to, the improvement of the diagnostic power (c.f. Fig. 2); reduction of the examination time; increase of the effective dose sensitivity by a factor of about 10 (i.e. [25]). This will result in a decrease of the required injected dose of 1 order of magnitude with a Whole-Body PET/CT dose of about 1 mSv. This will provide much needed flexibility in treatment planning (e.g. either by using PET as a less-invasive technique for a similar image quality or by enhancing the diagnostic power for a similar injected dose), and it will also enable improved and/or new modalities: e.g. i) use of PET imaging as pre- and post-natal diagnostic tool for detecting neuro-chemical abnormalities associated with neurologic disorders as well as to study normal brain development; ii) advancement of image-guided radiation therapy (e.g. improved disease extent appraisal, and assessment of therapy response); iii) better-earlier prediction of outcome or tumour recurrence; iv) selected screening applications, such as a secondary screen for lung cancer after obtaining suggestive low-dose CT results; v) distribution of radiotracers becomes more cost-effective if lower injected activities can still yield high-quality images. It may even be possible to distribute tracers based on shorter-lived radionuclides, particularly 11C; vi) multiple radiotracers imaging and eventually vii) direct ToF imaging. Finally this project is highly complementary to the current efforts to develop a first-generation total-body PET/CT scanners

Publications

10 25 50
 
Description Successful development of heterostructure scintillator materials. This includes precision machining of single crystal materials (matrix) both by contact and laser machining techniques, optimization of light transport of the matrix (coating) and development and encapsulation of an ultra-fast scintillator nanocomposite (filler) inside the matrix.
Exploitation Route The successful development of a heterostructure scintillator pixels prototype for Time of Flight Positron Emission Tomography (ToF-PET) has triggered numerous interested across the medical imaging community (end user, instrumentation and crystal producer companies). Several discussions on how to optimize the performance of the heterostructure and how to scale-up the production have been initiated.
Sectors Healthcare,Manufacturing, including Industrial Biotechology

 
Description PhD studentship - EPSRC - Centre for Doctoral Training in Ultra Precision Engineering
Amount £44,331 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 01/2019 
End 01/2022
 
Description New Crystal Clear Collaboration collaboration: development of heterostructure scintillator 
Organisation Academy of Sciences of the Czech Republic
Country Czech Republic 
Sector Academic/University 
PI Contribution Set-up of a formal Crystal Clear Collaboration Collaboration project on the development of heterostructure scintillators as a basis for scintillator based detectors with a time resolution towards 10ps in the frame of the 10ps challenge. Cranfield is involved in mulltiple work packages in direct relation with the development of heretostructure scintillator materials. - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: Cranfield - Simulation and heterostructure pixel design: Cranfield - Developement of microstructure: Cranfield - Realization of heterostructure pixels: Cranfield - Characterization of heterostructure pixel: Cranfield,
Collaborator Contribution - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: ILM, CTU, Ghent, FZU, Technion, UNIMIB, King's College London - Optical properties characterization of nanomaterials (time spectroscopy): CERN, CTU, FZU, ILM, LBL, Lomonosov (with Celia institute in Bordeaux), Tartu, Technion - Simulation and heterostructure pixel design: CERN, Technion - Developement of microstructure: CERN, Kurchatov, ISMA - Realization of heterostructure pixels: CERN, ISMA - Characterization of heterostructure pixel: Aachen, Anconna, CERN, - Coincidence time resolution performance: CERN - Image reconstruction: CERN, Uni Leeds.
Impact This collaboration will allow a concerted effort and a multidisciplinary approach to the development of heterostructure detector materials both scientifically and commercially. The agreement will allow sample exchange and access to each institution facility. The collaboration will meet to evaluate the progress and devise the best research pathways to success.
Start Year 2019
 
Description New Crystal Clear Collaboration collaboration: development of heterostructure scintillator 
Organisation Claude Bernard University Lyon 1 (UCBL)
Country France 
Sector Academic/University 
PI Contribution Set-up of a formal Crystal Clear Collaboration Collaboration project on the development of heterostructure scintillators as a basis for scintillator based detectors with a time resolution towards 10ps in the frame of the 10ps challenge. Cranfield is involved in mulltiple work packages in direct relation with the development of heretostructure scintillator materials. - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: Cranfield - Simulation and heterostructure pixel design: Cranfield - Developement of microstructure: Cranfield - Realization of heterostructure pixels: Cranfield - Characterization of heterostructure pixel: Cranfield,
Collaborator Contribution - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: ILM, CTU, Ghent, FZU, Technion, UNIMIB, King's College London - Optical properties characterization of nanomaterials (time spectroscopy): CERN, CTU, FZU, ILM, LBL, Lomonosov (with Celia institute in Bordeaux), Tartu, Technion - Simulation and heterostructure pixel design: CERN, Technion - Developement of microstructure: CERN, Kurchatov, ISMA - Realization of heterostructure pixels: CERN, ISMA - Characterization of heterostructure pixel: Aachen, Anconna, CERN, - Coincidence time resolution performance: CERN - Image reconstruction: CERN, Uni Leeds.
Impact This collaboration will allow a concerted effort and a multidisciplinary approach to the development of heterostructure detector materials both scientifically and commercially. The agreement will allow sample exchange and access to each institution facility. The collaboration will meet to evaluate the progress and devise the best research pathways to success.
Start Year 2019
 
Description New Crystal Clear Collaboration collaboration: development of heterostructure scintillator 
Organisation Cranfield University
Country United Kingdom 
Sector Academic/University 
PI Contribution Set-up of a formal Crystal Clear Collaboration Collaboration project on the development of heterostructure scintillators as a basis for scintillator based detectors with a time resolution towards 10ps in the frame of the 10ps challenge. Cranfield is involved in mulltiple work packages in direct relation with the development of heretostructure scintillator materials. - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: Cranfield - Simulation and heterostructure pixel design: Cranfield - Developement of microstructure: Cranfield - Realization of heterostructure pixels: Cranfield - Characterization of heterostructure pixel: Cranfield,
Collaborator Contribution - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: ILM, CTU, Ghent, FZU, Technion, UNIMIB, King's College London - Optical properties characterization of nanomaterials (time spectroscopy): CERN, CTU, FZU, ILM, LBL, Lomonosov (with Celia institute in Bordeaux), Tartu, Technion - Simulation and heterostructure pixel design: CERN, Technion - Developement of microstructure: CERN, Kurchatov, ISMA - Realization of heterostructure pixels: CERN, ISMA - Characterization of heterostructure pixel: Aachen, Anconna, CERN, - Coincidence time resolution performance: CERN - Image reconstruction: CERN, Uni Leeds.
Impact This collaboration will allow a concerted effort and a multidisciplinary approach to the development of heterostructure detector materials both scientifically and commercially. The agreement will allow sample exchange and access to each institution facility. The collaboration will meet to evaluate the progress and devise the best research pathways to success.
Start Year 2019
 
Description New Crystal Clear Collaboration collaboration: development of heterostructure scintillator 
Organisation Czech Technical University in Prague
Country Czech Republic 
Sector Academic/University 
PI Contribution Set-up of a formal Crystal Clear Collaboration Collaboration project on the development of heterostructure scintillators as a basis for scintillator based detectors with a time resolution towards 10ps in the frame of the 10ps challenge. Cranfield is involved in mulltiple work packages in direct relation with the development of heretostructure scintillator materials. - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: Cranfield - Simulation and heterostructure pixel design: Cranfield - Developement of microstructure: Cranfield - Realization of heterostructure pixels: Cranfield - Characterization of heterostructure pixel: Cranfield,
Collaborator Contribution - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: ILM, CTU, Ghent, FZU, Technion, UNIMIB, King's College London - Optical properties characterization of nanomaterials (time spectroscopy): CERN, CTU, FZU, ILM, LBL, Lomonosov (with Celia institute in Bordeaux), Tartu, Technion - Simulation and heterostructure pixel design: CERN, Technion - Developement of microstructure: CERN, Kurchatov, ISMA - Realization of heterostructure pixels: CERN, ISMA - Characterization of heterostructure pixel: Aachen, Anconna, CERN, - Coincidence time resolution performance: CERN - Image reconstruction: CERN, Uni Leeds.
Impact This collaboration will allow a concerted effort and a multidisciplinary approach to the development of heterostructure detector materials both scientifically and commercially. The agreement will allow sample exchange and access to each institution facility. The collaboration will meet to evaluate the progress and devise the best research pathways to success.
Start Year 2019
 
Description New Crystal Clear Collaboration collaboration: development of heterostructure scintillator 
Organisation European Organization for Nuclear Research (CERN)
Country Switzerland 
Sector Academic/University 
PI Contribution Set-up of a formal Crystal Clear Collaboration Collaboration project on the development of heterostructure scintillators as a basis for scintillator based detectors with a time resolution towards 10ps in the frame of the 10ps challenge. Cranfield is involved in mulltiple work packages in direct relation with the development of heretostructure scintillator materials. - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: Cranfield - Simulation and heterostructure pixel design: Cranfield - Developement of microstructure: Cranfield - Realization of heterostructure pixels: Cranfield - Characterization of heterostructure pixel: Cranfield,
Collaborator Contribution - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: ILM, CTU, Ghent, FZU, Technion, UNIMIB, King's College London - Optical properties characterization of nanomaterials (time spectroscopy): CERN, CTU, FZU, ILM, LBL, Lomonosov (with Celia institute in Bordeaux), Tartu, Technion - Simulation and heterostructure pixel design: CERN, Technion - Developement of microstructure: CERN, Kurchatov, ISMA - Realization of heterostructure pixels: CERN, ISMA - Characterization of heterostructure pixel: Aachen, Anconna, CERN, - Coincidence time resolution performance: CERN - Image reconstruction: CERN, Uni Leeds.
Impact This collaboration will allow a concerted effort and a multidisciplinary approach to the development of heterostructure detector materials both scientifically and commercially. The agreement will allow sample exchange and access to each institution facility. The collaboration will meet to evaluate the progress and devise the best research pathways to success.
Start Year 2019
 
Description New Crystal Clear Collaboration collaboration: development of heterostructure scintillator 
Organisation FH Aachen
Country Germany 
Sector Academic/University 
PI Contribution Set-up of a formal Crystal Clear Collaboration Collaboration project on the development of heterostructure scintillators as a basis for scintillator based detectors with a time resolution towards 10ps in the frame of the 10ps challenge. Cranfield is involved in mulltiple work packages in direct relation with the development of heretostructure scintillator materials. - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: Cranfield - Simulation and heterostructure pixel design: Cranfield - Developement of microstructure: Cranfield - Realization of heterostructure pixels: Cranfield - Characterization of heterostructure pixel: Cranfield,
Collaborator Contribution - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: ILM, CTU, Ghent, FZU, Technion, UNIMIB, King's College London - Optical properties characterization of nanomaterials (time spectroscopy): CERN, CTU, FZU, ILM, LBL, Lomonosov (with Celia institute in Bordeaux), Tartu, Technion - Simulation and heterostructure pixel design: CERN, Technion - Developement of microstructure: CERN, Kurchatov, ISMA - Realization of heterostructure pixels: CERN, ISMA - Characterization of heterostructure pixel: Aachen, Anconna, CERN, - Coincidence time resolution performance: CERN - Image reconstruction: CERN, Uni Leeds.
Impact This collaboration will allow a concerted effort and a multidisciplinary approach to the development of heterostructure detector materials both scientifically and commercially. The agreement will allow sample exchange and access to each institution facility. The collaboration will meet to evaluate the progress and devise the best research pathways to success.
Start Year 2019
 
Description New Crystal Clear Collaboration collaboration: development of heterostructure scintillator 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Set-up of a formal Crystal Clear Collaboration Collaboration project on the development of heterostructure scintillators as a basis for scintillator based detectors with a time resolution towards 10ps in the frame of the 10ps challenge. Cranfield is involved in mulltiple work packages in direct relation with the development of heretostructure scintillator materials. - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: Cranfield - Simulation and heterostructure pixel design: Cranfield - Developement of microstructure: Cranfield - Realization of heterostructure pixels: Cranfield - Characterization of heterostructure pixel: Cranfield,
Collaborator Contribution - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: ILM, CTU, Ghent, FZU, Technion, UNIMIB, King's College London - Optical properties characterization of nanomaterials (time spectroscopy): CERN, CTU, FZU, ILM, LBL, Lomonosov (with Celia institute in Bordeaux), Tartu, Technion - Simulation and heterostructure pixel design: CERN, Technion - Developement of microstructure: CERN, Kurchatov, ISMA - Realization of heterostructure pixels: CERN, ISMA - Characterization of heterostructure pixel: Aachen, Anconna, CERN, - Coincidence time resolution performance: CERN - Image reconstruction: CERN, Uni Leeds.
Impact This collaboration will allow a concerted effort and a multidisciplinary approach to the development of heterostructure detector materials both scientifically and commercially. The agreement will allow sample exchange and access to each institution facility. The collaboration will meet to evaluate the progress and devise the best research pathways to success.
Start Year 2019
 
Description New Crystal Clear Collaboration collaboration: development of heterostructure scintillator 
Organisation Kurchatov Institute
Country Russian Federation 
Sector Public 
PI Contribution Set-up of a formal Crystal Clear Collaboration Collaboration project on the development of heterostructure scintillators as a basis for scintillator based detectors with a time resolution towards 10ps in the frame of the 10ps challenge. Cranfield is involved in mulltiple work packages in direct relation with the development of heretostructure scintillator materials. - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: Cranfield - Simulation and heterostructure pixel design: Cranfield - Developement of microstructure: Cranfield - Realization of heterostructure pixels: Cranfield - Characterization of heterostructure pixel: Cranfield,
Collaborator Contribution - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: ILM, CTU, Ghent, FZU, Technion, UNIMIB, King's College London - Optical properties characterization of nanomaterials (time spectroscopy): CERN, CTU, FZU, ILM, LBL, Lomonosov (with Celia institute in Bordeaux), Tartu, Technion - Simulation and heterostructure pixel design: CERN, Technion - Developement of microstructure: CERN, Kurchatov, ISMA - Realization of heterostructure pixels: CERN, ISMA - Characterization of heterostructure pixel: Aachen, Anconna, CERN, - Coincidence time resolution performance: CERN - Image reconstruction: CERN, Uni Leeds.
Impact This collaboration will allow a concerted effort and a multidisciplinary approach to the development of heterostructure detector materials both scientifically and commercially. The agreement will allow sample exchange and access to each institution facility. The collaboration will meet to evaluate the progress and devise the best research pathways to success.
Start Year 2019
 
Description New Crystal Clear Collaboration collaboration: development of heterostructure scintillator 
Organisation Lawrence Berkeley National Laboratory
Country United States 
Sector Public 
PI Contribution Set-up of a formal Crystal Clear Collaboration Collaboration project on the development of heterostructure scintillators as a basis for scintillator based detectors with a time resolution towards 10ps in the frame of the 10ps challenge. Cranfield is involved in mulltiple work packages in direct relation with the development of heretostructure scintillator materials. - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: Cranfield - Simulation and heterostructure pixel design: Cranfield - Developement of microstructure: Cranfield - Realization of heterostructure pixels: Cranfield - Characterization of heterostructure pixel: Cranfield,
Collaborator Contribution - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: ILM, CTU, Ghent, FZU, Technion, UNIMIB, King's College London - Optical properties characterization of nanomaterials (time spectroscopy): CERN, CTU, FZU, ILM, LBL, Lomonosov (with Celia institute in Bordeaux), Tartu, Technion - Simulation and heterostructure pixel design: CERN, Technion - Developement of microstructure: CERN, Kurchatov, ISMA - Realization of heterostructure pixels: CERN, ISMA - Characterization of heterostructure pixel: Aachen, Anconna, CERN, - Coincidence time resolution performance: CERN - Image reconstruction: CERN, Uni Leeds.
Impact This collaboration will allow a concerted effort and a multidisciplinary approach to the development of heterostructure detector materials both scientifically and commercially. The agreement will allow sample exchange and access to each institution facility. The collaboration will meet to evaluate the progress and devise the best research pathways to success.
Start Year 2019
 
Description New Crystal Clear Collaboration collaboration: development of heterostructure scintillator 
Organisation Technion - Israel Institute of Technology
Country Israel 
Sector Academic/University 
PI Contribution Set-up of a formal Crystal Clear Collaboration Collaboration project on the development of heterostructure scintillators as a basis for scintillator based detectors with a time resolution towards 10ps in the frame of the 10ps challenge. Cranfield is involved in mulltiple work packages in direct relation with the development of heretostructure scintillator materials. - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: Cranfield - Simulation and heterostructure pixel design: Cranfield - Developement of microstructure: Cranfield - Realization of heterostructure pixels: Cranfield - Characterization of heterostructure pixel: Cranfield,
Collaborator Contribution - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: ILM, CTU, Ghent, FZU, Technion, UNIMIB, King's College London - Optical properties characterization of nanomaterials (time spectroscopy): CERN, CTU, FZU, ILM, LBL, Lomonosov (with Celia institute in Bordeaux), Tartu, Technion - Simulation and heterostructure pixel design: CERN, Technion - Developement of microstructure: CERN, Kurchatov, ISMA - Realization of heterostructure pixels: CERN, ISMA - Characterization of heterostructure pixel: Aachen, Anconna, CERN, - Coincidence time resolution performance: CERN - Image reconstruction: CERN, Uni Leeds.
Impact This collaboration will allow a concerted effort and a multidisciplinary approach to the development of heterostructure detector materials both scientifically and commercially. The agreement will allow sample exchange and access to each institution facility. The collaboration will meet to evaluate the progress and devise the best research pathways to success.
Start Year 2019
 
Description New Crystal Clear Collaboration collaboration: development of heterostructure scintillator 
Organisation University of Ancona
Country Italy 
Sector Academic/University 
PI Contribution Set-up of a formal Crystal Clear Collaboration Collaboration project on the development of heterostructure scintillators as a basis for scintillator based detectors with a time resolution towards 10ps in the frame of the 10ps challenge. Cranfield is involved in mulltiple work packages in direct relation with the development of heretostructure scintillator materials. - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: Cranfield - Simulation and heterostructure pixel design: Cranfield - Developement of microstructure: Cranfield - Realization of heterostructure pixels: Cranfield - Characterization of heterostructure pixel: Cranfield,
Collaborator Contribution - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: ILM, CTU, Ghent, FZU, Technion, UNIMIB, King's College London - Optical properties characterization of nanomaterials (time spectroscopy): CERN, CTU, FZU, ILM, LBL, Lomonosov (with Celia institute in Bordeaux), Tartu, Technion - Simulation and heterostructure pixel design: CERN, Technion - Developement of microstructure: CERN, Kurchatov, ISMA - Realization of heterostructure pixels: CERN, ISMA - Characterization of heterostructure pixel: Aachen, Anconna, CERN, - Coincidence time resolution performance: CERN - Image reconstruction: CERN, Uni Leeds.
Impact This collaboration will allow a concerted effort and a multidisciplinary approach to the development of heterostructure detector materials both scientifically and commercially. The agreement will allow sample exchange and access to each institution facility. The collaboration will meet to evaluate the progress and devise the best research pathways to success.
Start Year 2019
 
Description New Crystal Clear Collaboration collaboration: development of heterostructure scintillator 
Organisation University of Ghent
Country Belgium 
Sector Academic/University 
PI Contribution Set-up of a formal Crystal Clear Collaboration Collaboration project on the development of heterostructure scintillators as a basis for scintillator based detectors with a time resolution towards 10ps in the frame of the 10ps challenge. Cranfield is involved in mulltiple work packages in direct relation with the development of heretostructure scintillator materials. - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: Cranfield - Simulation and heterostructure pixel design: Cranfield - Developement of microstructure: Cranfield - Realization of heterostructure pixels: Cranfield - Characterization of heterostructure pixel: Cranfield,
Collaborator Contribution - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: ILM, CTU, Ghent, FZU, Technion, UNIMIB, King's College London - Optical properties characterization of nanomaterials (time spectroscopy): CERN, CTU, FZU, ILM, LBL, Lomonosov (with Celia institute in Bordeaux), Tartu, Technion - Simulation and heterostructure pixel design: CERN, Technion - Developement of microstructure: CERN, Kurchatov, ISMA - Realization of heterostructure pixels: CERN, ISMA - Characterization of heterostructure pixel: Aachen, Anconna, CERN, - Coincidence time resolution performance: CERN - Image reconstruction: CERN, Uni Leeds.
Impact This collaboration will allow a concerted effort and a multidisciplinary approach to the development of heterostructure detector materials both scientifically and commercially. The agreement will allow sample exchange and access to each institution facility. The collaboration will meet to evaluate the progress and devise the best research pathways to success.
Start Year 2019
 
Description New Crystal Clear Collaboration collaboration: development of heterostructure scintillator 
Organisation University of Kharkiv
Country Ukraine 
Sector Academic/University 
PI Contribution Set-up of a formal Crystal Clear Collaboration Collaboration project on the development of heterostructure scintillators as a basis for scintillator based detectors with a time resolution towards 10ps in the frame of the 10ps challenge. Cranfield is involved in mulltiple work packages in direct relation with the development of heretostructure scintillator materials. - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: Cranfield - Simulation and heterostructure pixel design: Cranfield - Developement of microstructure: Cranfield - Realization of heterostructure pixels: Cranfield - Characterization of heterostructure pixel: Cranfield,
Collaborator Contribution - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: ILM, CTU, Ghent, FZU, Technion, UNIMIB, King's College London - Optical properties characterization of nanomaterials (time spectroscopy): CERN, CTU, FZU, ILM, LBL, Lomonosov (with Celia institute in Bordeaux), Tartu, Technion - Simulation and heterostructure pixel design: CERN, Technion - Developement of microstructure: CERN, Kurchatov, ISMA - Realization of heterostructure pixels: CERN, ISMA - Characterization of heterostructure pixel: Aachen, Anconna, CERN, - Coincidence time resolution performance: CERN - Image reconstruction: CERN, Uni Leeds.
Impact This collaboration will allow a concerted effort and a multidisciplinary approach to the development of heterostructure detector materials both scientifically and commercially. The agreement will allow sample exchange and access to each institution facility. The collaboration will meet to evaluate the progress and devise the best research pathways to success.
Start Year 2019
 
Description New Crystal Clear Collaboration collaboration: development of heterostructure scintillator 
Organisation University of Leeds
Country United Kingdom 
Sector Academic/University 
PI Contribution Set-up of a formal Crystal Clear Collaboration Collaboration project on the development of heterostructure scintillators as a basis for scintillator based detectors with a time resolution towards 10ps in the frame of the 10ps challenge. Cranfield is involved in mulltiple work packages in direct relation with the development of heretostructure scintillator materials. - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: Cranfield - Simulation and heterostructure pixel design: Cranfield - Developement of microstructure: Cranfield - Realization of heterostructure pixels: Cranfield - Characterization of heterostructure pixel: Cranfield,
Collaborator Contribution - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: ILM, CTU, Ghent, FZU, Technion, UNIMIB, King's College London - Optical properties characterization of nanomaterials (time spectroscopy): CERN, CTU, FZU, ILM, LBL, Lomonosov (with Celia institute in Bordeaux), Tartu, Technion - Simulation and heterostructure pixel design: CERN, Technion - Developement of microstructure: CERN, Kurchatov, ISMA - Realization of heterostructure pixels: CERN, ISMA - Characterization of heterostructure pixel: Aachen, Anconna, CERN, - Coincidence time resolution performance: CERN - Image reconstruction: CERN, Uni Leeds.
Impact This collaboration will allow a concerted effort and a multidisciplinary approach to the development of heterostructure detector materials both scientifically and commercially. The agreement will allow sample exchange and access to each institution facility. The collaboration will meet to evaluate the progress and devise the best research pathways to success.
Start Year 2019
 
Description New Crystal Clear Collaboration collaboration: development of heterostructure scintillator 
Organisation University of Milano-Bicocca
Country Italy 
Sector Academic/University 
PI Contribution Set-up of a formal Crystal Clear Collaboration Collaboration project on the development of heterostructure scintillators as a basis for scintillator based detectors with a time resolution towards 10ps in the frame of the 10ps challenge. Cranfield is involved in mulltiple work packages in direct relation with the development of heretostructure scintillator materials. - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: Cranfield - Simulation and heterostructure pixel design: Cranfield - Developement of microstructure: Cranfield - Realization of heterostructure pixels: Cranfield - Characterization of heterostructure pixel: Cranfield,
Collaborator Contribution - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: ILM, CTU, Ghent, FZU, Technion, UNIMIB, King's College London - Optical properties characterization of nanomaterials (time spectroscopy): CERN, CTU, FZU, ILM, LBL, Lomonosov (with Celia institute in Bordeaux), Tartu, Technion - Simulation and heterostructure pixel design: CERN, Technion - Developement of microstructure: CERN, Kurchatov, ISMA - Realization of heterostructure pixels: CERN, ISMA - Characterization of heterostructure pixel: Aachen, Anconna, CERN, - Coincidence time resolution performance: CERN - Image reconstruction: CERN, Uni Leeds.
Impact This collaboration will allow a concerted effort and a multidisciplinary approach to the development of heterostructure detector materials both scientifically and commercially. The agreement will allow sample exchange and access to each institution facility. The collaboration will meet to evaluate the progress and devise the best research pathways to success.
Start Year 2019
 
Description New Crystal Clear Collaboration collaboration: development of heterostructure scintillator 
Organisation University of Tartu
Country Estonia 
Sector Academic/University 
PI Contribution Set-up of a formal Crystal Clear Collaboration Collaboration project on the development of heterostructure scintillators as a basis for scintillator based detectors with a time resolution towards 10ps in the frame of the 10ps challenge. Cranfield is involved in mulltiple work packages in direct relation with the development of heretostructure scintillator materials. - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: Cranfield - Simulation and heterostructure pixel design: Cranfield - Developement of microstructure: Cranfield - Realization of heterostructure pixels: Cranfield - Characterization of heterostructure pixel: Cranfield,
Collaborator Contribution - Theoretical understanding of excitation in nanomaterial: Lomonosov institute - Nanomaterial chemistry understanding and synthesis: ILM, CTU, Ghent, FZU, Technion, UNIMIB, King's College London - Optical properties characterization of nanomaterials (time spectroscopy): CERN, CTU, FZU, ILM, LBL, Lomonosov (with Celia institute in Bordeaux), Tartu, Technion - Simulation and heterostructure pixel design: CERN, Technion - Developement of microstructure: CERN, Kurchatov, ISMA - Realization of heterostructure pixels: CERN, ISMA - Characterization of heterostructure pixel: Aachen, Anconna, CERN, - Coincidence time resolution performance: CERN - Image reconstruction: CERN, Uni Leeds.
Impact This collaboration will allow a concerted effort and a multidisciplinary approach to the development of heterostructure detector materials both scientifically and commercially. The agreement will allow sample exchange and access to each institution facility. The collaboration will meet to evaluate the progress and devise the best research pathways to success.
Start Year 2019
 
Description Medami 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Workshop was attended to present our material development driven project to an audience highly specialized in medical imaging (academics, end users and companies) but not directly involved in the material development. The entire project, goal, challenges and output, was presented. The project, recognized as one of the only way to reach 10ps time resolution of the ToF-PET, has definitely triggered some interest from both end users and companies. Further discussions and plans were made to define how to better support the development of ultra-fast heterostructure detector for ToF-PET and eventually transition the technology from laboratory to industry.
Year(s) Of Engagement Activity 2019
URL https://www.i3m.upv.es/medami2019/
 
Description New Crystal Clear Collaboration project: development of heterostructure scintillator 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Set-up of a formal Crystal Clear Collaboration Collaboration project on the development of heterostructure scintillators as a basis for scintillator based detectors with a time resolution towards 10ps in the frame of the 10ps challenge. This includes 17 institutes of which 11 are CCC members and 6 non-CCC members :

11 CCC members institutes :
CERN, Switzerland (Etiennette Auffray); CTU, Prague , Czeck Republic (V. Cuba); Kurchatov institute, Moscow, Russia (G. Dosovitskiy); ILM, Lyon, France (Christophe Dujardin); FZU, Prague Czech republic (M. Nikl); Tartu university, Estonia (Sergey Omelkov); University of Anconna, Italy (D. Rinaldi); ISMA Kharkov, Ukraine, (Oleg Sidelsky); University of leeds, UK (Harry Tsoumpas) ; Lomonosov Institute, Moscow, Russia (Andrei Vasilev); FH Aachen, Germany (Karl Ziemons)

Six non- CCC members institutes :
University Cranfield, UK (Greg Bizarri); LBL, Berkeley, US (Edith Bourret-Courchesne); Technion University (Ido Kaminer); Ghent University, Belgium (Iwan Moreel); UniMIB, Milano, Italy (Anna Vedda), King's College London, UK (Harris Makatsoris);

A first list of activities in which each institute contribute has been establish:
- Theoretical understanding of excitation in nanomaterial: Lomonosov institute
- Nanomaterial chemistry understanding and synthesis: ILM, CTU, Ghent, FZU, Technion, UNIMIB, Cranfield, King's College London
- Optical properties characterization of nanomaterials (time spectroscopy): CERN, CTU, FZU, ILM, LBL, Lomonosov (with Celia institute in Bordeaux), Tartu, Technion
- Simulation and heterostructure pixel design: CERN, Cranfield, Technion
- Developement of microstructure: CERN, Cranfield, Kurchatov, ISMA
- Realization of heterostructure pixels: CERN, Cranfield, ISMA
- Characterization of heterostructure pixel: Aachen, Anconna, CERN, Cranfield,
- Coincidence time resolution performance: CERN
- Image reconstruction: CERN, Uni Leeds.

This collaboration will allow a concerted effort and a multidisciplinary approach to efficiently enable the future of heterostructure material detectors both scientifically and commercially.
Year(s) Of Engagement Activity 2019
URL https://crystalclear.web.cern.ch/crystalclear/
 
Description Organisation of the 1st workshop Workshop on scintillator metastructures 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The workshop, co-organized by CERN (P. Lecoq) and the Cranfield University (G. Bizarri) has been held at CERN, on Nov 12-13 2019. More than 40 scientists from 15 different countries have participate and presentated their work in direct relation with the future of heterostructure detector material development.
The workshop was designed to primaraly focus on the development of ultra-fast heterostructure mmaterials for Time of Flight Positron Emission Tomography (ToF-PET). As stated in the advertisement of the workshop:

"""In the context of the 10ps Time-of-Flight Positron Emission Tomography (TOFPET) challenge (https://the10ps-challenge.org/), a new class of scintillators needs to be developed. combining the high stopping power and photoelectric cross section of standard scintillators, such as BGO and LSO with the ultrafast scintillation properties of high donor band semi-conductors or quantum confined (multi)-excitonic emission of nanocrystals.
The development of such high performance multi-material radiation sensing heterostructures has recently received some further support with the first demonstration/measurement of the energy sharing mechanism projected from the absorption of a 511keV gamma ray in such heterostructures. This is an important step stone. To extend this effort toward the development of more commercially relevant heterostructure PET pixels, we now believe that the establishment of an intersectoral/multidisciplinary community helping to regroup our efforts, define a common strategy, and seek for funding is crucial.
Toward these aims and along this very promising line of research, we would like to discuss during a 2 days' workshop three primary and scientifically interconnected areas:
· Heterostructure Design - Simulations and optimization
· Fast component Development - Performance and technical requirements (density, light yield, scintillation kinetics, transparency, possibility to embed in a host (polymer), production methods and scalability, etc)
· Heterostructure Assembly - Integration of the two scintillator components, with a particular focus on the light collection and performance optimization""""

The workshop has served to survey the current state of art in the field of heterostructure radiation detectors, devise the most promising avenues to explore and initiate the appropriate collaboration across the institutions.
There will be a follow up workshop to assess the progress in 2020 and 2021.
Year(s) Of Engagement Activity 2019
 
Description Quantum Dot Day 2020 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation given on the development and optimization of ultra-fast nanoparticle loaded polymers for Time of Flight Positron Emission Tomography scanners. The main goal was to present and discuss our results with a highly skill audience of physicists and chemists not directly involved with the medical sector. This aimed to provide a different view on our specific scientific challenges. Discussions were fruitful providing interesting path forward that will be further evaluated in laboratories.
Year(s) Of Engagement Activity 2020
URL http://qdd2020.iopconfs.org/home
 
Description SCINT2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation was given to an audience highly specialized in the development of scintillator materials. The intent was to discuss the scientific challenges related to heterostructure material development and the complex energy transfer mechanisms that are directly associated with it. The presentation of our preliminary results was extremely well received and further discussions were started on how to optimize and scale-up the production of the heterostructures.
Year(s) Of Engagement Activity 2019
URL http://www.scint2019.imr.tohoku.ac.jp/