Accelerated Discovery and Development of New Medicines: Prosperity Partnership for a Healthier Nation

Lead Research Organisation: University of Strathclyde
Department Name: Pure and Applied Chemistry

Abstract

GSK is a global healthcare company that discovers, develops and manufactures medicines to treat a range of conditions including: respiratory diseases, cancer, heart disease, epilepsy, bacterial and viral infections (such as HIV and lupus), and skin conditions like psoriasis. GSK makes over 4 billion packs of medicines each year, with the goal of playing its part in meeting some of society's biggest healthcare challenges.

Alongside a mission to provide transformative medicines to patients, GSK continually seeks to improve the efficiency and sustainability of our processes across the discovery, manufacturing, and delivery components of our supply chain. Indeed, GSK are committed to ambitious sustainability goals by 2050 that can only be achieved by making existing and future medicines via better routes, driving innovation all the way from the first design of the molecule through to patients in the clinic.

This Prosperity Partnership aims to build on existing vibrant collaborations between GSK and the Universities of Nottingham and Strathclyde. The strengths of each partner will be leveraged to deliver a new suite of methods and approaches to tackle some of the major challenges in the discovery, development, and manufacture of medicines. Our vision is to increase efficiency in terms of atoms, energy, and time; resulting in transformative medicines at lower costs, reduced waste production, and shorter manufacturing routes.

Key challenge areas, or themes, covered in our partnership include:

1. The development and application of Artificial Intelligence (AI) and Machine Learning to the efficient identification of next generation medicines: in Drug Discovery, many hundreds of candidate structures are designed, prepared, and tested to find the molecule with the right profile to take into the clinic. The development of AI informed decision making has the potential to deliver huge savings by minimising the number of compounds that need to be made at this stage. The software developed will incorporate green chemistry principles with the goal that the chemical methods employed are as efficient and sustainable as possible.

2. Next generation catalysis and synthesis: Chemists seeking to discover new medicines need new reactions that will allow them to make and investigate structures that are currently difficult, or even impossible, to make. A key objective of this proposal will be to develop new reagents, catalysts, and reactions to facilitate the more efficient preparation of drug-like molecules to accelerate drug discovery. Similarly, we will develop new ways of performing some of the most common chemical transformations in the synthesis of medicines whilst avoiding the use of carcinogenic reagents.

3. Sustainable processes that deliver efficiency and transition to scale-up from grammes to kilogrammes. Currently under-utilised approaches, such as electrochemistry, will be explored for their ability to catalyse reactions with cheaper and less environmentally impactful metals, such as replacing palladium with nickel.

4. A new Digital Design toolset for equipment will enable Digital Manufacturing of novel pharmaceutical processing equipment. Current development relies on existing traditional vessels and flow reactors that compromise our ability to deliver processes that operate at optimal performance. The research will couple advanced process models, state-of-the-art experimentation, and 3-D printing/additive manufacturing technologies to revolutionise how we develop, scale up, and operate chemical processes to supply new medicines.

Integration of the projects and the expertise from the three partner institutions, and the successful prosecution of our research objectives, will make a major contribution to the wider pharmaceutical sector and, indeed, GSK's mission of discovering and developing transformative medicines faster to help people do more, feel better, and live longer.

Planned Impact

This Prosperity Partnership will have positive impacts in the following areas:
PEOPLE. Ultimately, the delivery of better medicines using smarter methods with shorter lead times will have a notable impact upon the health, wellbeing, and prosperity of the nation and worldwide. On a more local level, this Partnership will facilitate and drive the training of a cadre of highly skilled scientists who will share technical excellence and the wider impacts of their science both locally and globally.
The pharmaceutical industry constantly needs cutting edge science to deliver transformative medicines, increased sustainability, and better manufacturing processes. This drives a continuing demand for highly qualified and skilled scientists to lead innovation and manage change in these areas. As part of our Partnership we will deploy an inclusive cohort-based training network, spanning all 3 partners, which will provide industry-ready scientists with advanced technical competencies and leadership to ensure that the sector retains its primary position in innovation and productivity.
ECONOMY. A healthier nation is a more productive nation. Enhanced delivery of better medicines, envisioned by this proposal, allows people to do more. Drug discovery, development, and manufacturing are immensely challenging processes, particularly when sustainability is included. Addressing these challenges, this Partnership will deploy machine learning approaches to enable data-driven decision making in target generation and synthetic route definition. We will expedite optimal syntheses by using responsive digital methods to deliver energy and material resilient production to secure continued growth through innovation. Successes from this Partnership will be applicable across both the pharmaceutical and wider chemical industries, as many of the processes will be readily transferable.
SOCIETY. The diverse range of products manufactured by the pharmaceutical and chemical industries is vital to maintain the prosperity of the UK. Our Partnership will have a direct impact by ensuring the supply of trained people and new knowledge for increased health and sustainability for all. Health awareness and "green and sustainable" agendas are now fixed in the public consciousness, and there is an increased expectation for the pharmaceutical industry to deliver accordingly. Recent developments in AI and machine learning offer new tools for particular application in the discovery of new molecular entities through medicinal chemistry and early development. This Partnership will also seek to deploy novel chemistries, better catalysis, and state of the art processing opportunities to deliver potent materials with vastly increased sustainability. Being able to deliver these outputs in such an energy-efficient fashion will engender a sustainability ethos unique to the UK.
Engagement is also a crucial component of this Partnership; we will invite input and discussion from the public via lectures, showcases, and exhibition days. The Carbon Neutral Laboratory at Nottingham and Strathclyde's Engage Week will form hubs for technology open days and will provide key interfaces to give school pupils and young adults the opportunity to view science from the inside. We will broaden the impacts of our science by wider dissemination not only to the GSK/pharmaceuticals community but also across any who, directly or indirectly, have a shared interest in the prosperity of this sector.
KNOWLEDGE. In addition to the supply of highly trained people, this Partnership will have a major impact on knowledge. Our PDRAs and PhD candidates will tackle challenges at the forefront of sustainable pharmaceutical chemistry and through our links to GSK we will apply this knowledge to industry, whilst also filing patents and publishing in high impact journals. Our knowledge-based activities will drive innovation and economic activity, realising impact through creation of new jobs and securing our future.

Publications

10 25 50

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Beddoe RH (2019) Redox-neutral organocatalytic Mitsunobu reactions. in Science (New York, N.Y.)

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Clark P (2020) A Scalable, Metal-, Azide- and Halogen-Free Method for the Preparation of Triazoles. in Angewandte Chemie (International ed. in English)

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Clark PR (2019) Copper-catalysed C-H functionalisation gives access to 2-aminobenzimidazoles. in Organic & biomolecular chemistry

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Fusani L (2020) Exploring Ligand Stability in Protein Crystal Structures Using Binding Pose Metadynamics. in Journal of chemical information and modeling

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Grant EK (2019) A Photoaffinity Displacement Assay and Probes to Study the Cyclin-Dependent Kinase Family. in Angewandte Chemie (International ed. in English)

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Jordan A (2020) Development of a More Sustainable Appel Reaction in ACS Sustainable Chemistry & Engineering

 
Description The overall objectives of this research programme can be divided into four main Themes:

Theme 1: Establish AI-enabled medicinal chemistry programmes that accelerate the discovery of new, efficacious drug molecules by developing, applying, and refining algorithms and computationally-enabled processes to design drug-like and developable molecules.

Themes 2a and 2b: Deliver next generation catalysis and synthesis methods to provide access to new reactions and catalytic processes that will enable the more rapid synthesis of novel and desirable structures for application within drug discovery programmes, and which can be seamlessly transitioned to larger scale applications.

Theme 3: Develop sustainable processes that deliver efficiency and transition to scale-up from grammes to kilogrammes by minimising the amount of chemicals, solvents, and processing steps required to construct drug-like molecules.

Theme 4: Create resilient and responsive manufacturing approaches (Digital Manufacturing) to accelerate the larger scale production of new medicines by placing digital technologies at the heart of pharmaceutical manufacturing and which will have tangible resonance across the whole pharmaceutical value chain.

Postdoctoral researchers have been engaged in Themes 1, 2a and 2b since October 2019; postdoctoral researchers in Themes 3 and 4 will join the porgramme in the first half of 2020.

Within Theme 1, we are currently working towards the objective of the development and application of Artificial Intelligence (AI) and Machine Learning to the efficient identification of next generation medicines. Activity to date on this objective comprises: (i) operationalisation of Free Energy Perturbation computational machinery; (ii) assessment of the reproducibility, accuracy, and generalisability of literature studies on relevant molecular systems; (iii) a diversity analysis of datasets from GSK; and (iv) QSAR analyses of datasets from GSK.

Within Theme 2a, we are developing new methods to broaden the scope in synthetic chemistry methodology for the selective functionalisation of N-Me groups. Within this area, appreciable advances have already been made towards expanding the reaction partners which undergo this novel chemistry.

Within Theme 2b, novel ligands are being designed and synthesised with the goal of establishing a new and efficient asymmetric 1,4-addition to electrophiles of direct pharmaceutical relevance. Already, proof-of-concept results have been obtained using a novel ligand class, with excellent stereoselectivities observed against benchmark substrates.
Exploitation Route Too early to say (the award is still active).
Sectors Chemicals,Digital/Communication/Information Technologies (including Software),Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

 
Title GSK Compound Dataset 
Description A substantial dataset (>2000 compounds, >10000 data points) of GSK compounds associated with a specific medicinal target, and shared with Nottingham and Strathclyde Prosperity Partnership colleagues. The dataset is being used for the training and validation of models and development of chemical equity within the Partnership. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? No  
Impact The dataset is being used for the training and validation of models aiming at using AI and machine learning within drug discovery. 
 
Description BBC East Midlands Today Climate Change Special 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The University of Nottingham GSK Carbon Neutral Laboratories hosted an edition of the BBC East Midlands Today (23 January 2020). Prof. Peter Licence was involved and during the broadcast he described Prosperity Partnership activity and other areas of thematic science. Additionally, he spoke of the importance of greener more sustainable approaches, and highlighted the collaboration with GSK.
Year(s) Of Engagement Activity 2020
URL https://suschem-nottingham-cdt.ac.uk/index.php/news-blog/article/carbon-neutral-laboratories-buildin...
 
Description Conference Flash Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Ross Thomas delivered a flash presentation at the ChemBiOx meeting held in Oxford from 30th-31st July 2019. The title of the presentation was "High-throughput synthesis of PhotoAffinity Bits (PhABits) to study protein-ligand binding".
Year(s) Of Engagement Activity 2019
 
Description Conference Oral Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Peter Clark gave an oral presentation on his research at the SCI Fine Chemicals Group's 30th Regional Postgraduate Symposium on Novel Organic Chemistry - Scotland, held at the University of Glasgow on 15th April 2019.
Year(s) Of Engagement Activity 2019
 
Description Conference Oral Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Oliver Turner gave an oral presentation on his research at the SCI Fine Chemicals Group's 30th Regional Postgraduate Symposium on Novel Organic Chemistry, held at the University of Glasgow on the 15th April 2019. The title of his presentation was "New Hydrogen Atom Transfer Methodologies".
Year(s) Of Engagement Activity 2019
 
Description Conference Oral Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student James Thompson gave an oral presentation on his research at the RSC's 'Twenty years of the rule of 5' symposium, held at the University of Nottingham on 20th November 2019. The title of his presentation was "Investigating the chameleonic properties of aVß6 integrin antagonists for the treatment of IPF".
Year(s) Of Engagement Activity 2019
 
Description Conference Oral Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Enrique Bendito-Moll gave an oral presentation on his research at the Young Research Scientist 2019 meeting held in Madrid, Spain, in June 2019. The title of his presentation was "Mechanistic insight insight enables practical, scalable, room temperature N-arylation of N-aryl sulfonamides".
Year(s) Of Engagement Activity 2019
 
Description Conference Oral Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde.GSK Collaborative PhD student Luke Whitaker gave an oral presentation on his research at the ACS Fall national Meeting, held in San Diego from 25th-29th August 2019. The title of his talk was "Reductive Etherification".
Year(s) Of Engagement Activity 2019
 
Description Conference Oral Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student John Priestner gave a oral presentation on his research at the RSC's 'Twenty years of the rule of 5' symposium, held at the University of Nottingham on 20th November 2019. The title of his oral presentation was "Investigating the effects of linker functionality on the phyiscochemical properties of BET PROTACs".
Year(s) Of Engagement Activity 2019
 
Description Conference Oral Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Lucia Fusani gave an oral presentation on her research at the MM2019 Meeting, held in Bintan, Indonesia, from 5th-8th December 2019.
Year(s) Of Engagement Activity 2019
 
Description Conference Oral Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student James Thompson gave an oral presentation on his research at the 2nd Winter Alpine Conference on Medicinal and Synthetic Chemistry, held in St Anton, Austria, from the 19th-23rd January 2020. The title of his presentation was "Investigating the chameleonic properties of aVß6 integrin antagonists for the treatment of IPF".
Year(s) Of Engagement Activity 2020
 
Description Conference Oral Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Peter Clark gave a poster presentation on his research at the 2nd Alpine Winter Symposium, held in Austria in January 2020.
Year(s) Of Engagement Activity 2020
 
Description Conference Oral Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Jack Washington gave an oral presentation on his research at the SCI Fine Chemical Group's "30th Regional Postgraduate Symposium on Novel Organic Chemistry - Scotland", held at the University of Glasgow on 15th April 2019. The title of his talk was "Trimethylanilinium salts in methylation reactions"
Year(s) Of Engagement Activity 2019
 
Description Conference Oral Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Jack Washington gave an oral presentation on his research at the ACS National Meeting in San Diego, USA, held in August 2019. The title of his talk was "pH and Temperature effects on the process-scale degradation of clavulanic acid"
Year(s) Of Engagement Activity 2019
 
Description Conference Oral Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Maxime Rouah gave an oral presentation on his research at the Bioimaging Network Symposium held from 20th-21st June 2019. The title of his presentation was "Discovery of bioorthogonal chemical probes for the cellular imaging and target engagement measurement of inhaled PI3Kd inhibitors".
Year(s) Of Engagement Activity 2019
 
Description Conference Oral Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Maxime Rouah gave an oral presentation on his research at the ChemBiOx meeting held at the University of Oxford from 30th-31st August 2019. The title of his presentation was "Discovery of bioorthogonal chemical probes for the cellular imaging and target engagement measurement of inhaled PI3Kd inhibitors".
Year(s) Of Engagement Activity 2019
 
Description Conference Oral Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Peter Clark gave an oral presentation on his research at Scientific Update's 6th Winter Process Chemistry Symposium, held in December 2019.
Year(s) Of Engagement Activity 2019
 
Description Conference Oral Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Strathclyde/GSK Collaborative PhD student Jessie Tucker gave a poster presentation on her research at the Young Chemist in Industry Meeting, held at Syngenta, Jealott's Hill, on 4th November 2019. The title of her presentation was "The Use of Contemporary Chemoproteomic Techniques in Antimalarial Target Identification".
Year(s) Of Engagement Activity 2019
 
Description Conference Oral Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Maxime Rouah gave an oral presentation on his research at the ACS National Fall Meeting, held in San Diego, USA, from 23rd-29th August 2019. The title of his presentation was "Bioorthogonal chemistry approaches for the cellular imaging on inhaled PI3Kdelta inhibitors".
Year(s) Of Engagement Activity 2019
 
Description Conference Oral Presetation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Maxime Rouah gave an oral presentation on his research at the RSC's "Bioorthogonal and Bioresponsive" meeting held in Edinburgh from 6th-7th June 2019. The title of his presentation was "Discovery of bioorthogonal chemical probes for the cellular imaging and target engagement measurement of inhaled PI3Kd inhibitors".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student John Priestner gave a poster presentation on his research at the SCI's Targeting the Ubiquitin Proteasome Pathway II, held in London on the 12th-13th June 2019. The title of his poster presentation was "Investigating the effects of linker functionality on the phyiscochemical properties of BET PROTACs".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Ross Thomas presented a poster on his research at the ChemBiOx meeting held in Oxford from 30th-31st July 2019. The title of the poster presentation was "High-throughput synthesis of PhotoAffinity Bits (PhABits) to study protein-ligand binding".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Jack Washington gave a poster presentation on his research at the ACS National Meeting in San Diego, USA, in August 2019. The title of his poster presentation was "pH and Temperature effects on the process-scale degradation of clavulanic acid"
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student John Priestner gave a poster presentation on his research at the SCI's Protein-Protein Interactions 2019 Meeting, held at the University of Leeds on 4th-5th April 2019. The title of his poster presentation was "Investigating the effects of linker functionality on the phyiscochemical properties of BET PROTACs".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Rishi Shah gave a poster presentation on his research at the Chemical Biology and Bio-Organic Group (CBBG) Forum, held at the Manchester Institute of Biotechnology at the University of Manchester, in March 2019. The title of his poster presentation was "Hi-JAK-ing The Ubiquitin System: The Design and Physicochemical Optimisation JAK PROTACs"
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde.GSK Collaborative PhD student Luke Whitaker presented a poster on his research at the Nanyang Research Conference on Synthetic Chemistry and Catalysis, held in Singapore from 15th-17th January 2020. The title of his poster presentation was "Reductive Etherification".
Year(s) Of Engagement Activity 2020
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Peter Clark gave a poster presentation on his research at Scientific Update's 6th Winter Process Chemistry Conference, held in December 2019.
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Brett Cosgrove gave a poster presentation on his research at the 6th EFMC-Young Medicinal Chemist Symposium, held in Athens, Greece, in August 2019. The title of his poster presentation was "Targeting non-cysteine residues selectively in PI4KIIIß using fluorosulfates as covalent warheads".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD Student Alfie Wills presented a poster on his research entitled "A selectivity switch in the electrochemical oxidation of 4-methylansiole". The research was presented at the RSC Organic Division South East Regional Meeting, held at the University of Greenwich on 13th February 2019.
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Holly Bonfield presented a poster on her research at the International Symposium on Synthesis and Catalysis 2019, held in Evora, Portugal, 2-6 September 2019. The poster was entitled "De Novo Design of a Robust Modular Photochemical Reactor for Optimum Batch and Flow Chemistry"
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Heather Gray presented a poster on her research at the RSC's "Integrin Targeted Drug Discovery" conference held in London on 28th March 2019. The title of her poster presentation was "Rationalisation of avß6 Selectivity for Clinical Candidate GSK3008348 in the Treatment of Idiopathic Pulmonary Fibrosis"
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student John Priestner gave a poster presentation on his research at the 11th SEQT Young Researchers Symposium on 21st June 2019. The title of his poster presentation was "Investigating the effects of linker functionality on the phyiscochemical properties of BET PROTACs".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Maxime Rouah gave a poster presentation on his research at the RSC's "Bioorthogonal and Bioresponsive" Meeting, held in Edinburgh from 6th-7th June 2019. The title of his poster presentation was "Discovery of bioorthogonal chemical probes for the cellular imaging and target engagement measurement of inhaled PI3Kd inhibitors".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Lucia Fusani gave a poster presentation on her research at the Young Researcher Symposium, GSK Tres Cantos, Spain, on 21st June 2019.
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD Student Alfie Wills presented a poster on his research entitled "A selectivity switch in the electrochemical oxidation of 4-methylansiole". The research was presented at the Electrochem 19 conference, organised jointly by the RSC Electrochemistry Group and the SCI Electrochemical Technology Group, and held at the University of Strathclyde on 28th August 2019.
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Sam Holman gave a poster presentation on his research at the Grasmere (Lakeland) Conference; Grasmere, UK, in July 2019. The title of his poster presentation was "Electrochemically Enabled Synthesis of Substituted Isoxazolines".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Maxime Rouah gave a poster presentation on his research at the RSC Chemical Biology Symposium 2019, held in London on the 20th May 2019. The title of his poster presentation was "Discovery of bioorthogonal chemical probes for the cellular imaging and target engagement measurement of inhaled PI3Kd inhibitors".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Maxime Rouah gave a poster presentation on his research at the Bioimaging Network Symposium, held from 20th-21st June 2019. The title of his poster presentation was "Discovery of bioorthogonal chemical probes for the cellular imaging and target engagement measurement of inhaled PI3Kd inhibitors".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Emma Grant presented a poster on her research at the RSC's 2nd Anglo-Nordic Medicinal Chemistry Symposium, held in Denmark in June 2019.
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Ross Thomas presented a poster on his research at the Chemical Biology and Bio-Organic Group (CBBG) Forum at the University of Leicester on the 10th January 2020. The title of the poster presentation was "High-throughput synthesis of PhotoAffinity Bits (PhABits) to study protein-ligand binding".
Year(s) Of Engagement Activity 2020
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Jack Roberts presented a poster on his research at the RSC's "Artificial Intelligence in Chemistry" meeting, held in Cambridge, UK, from the 2nd-3rd September 2019. The title of his poster presentation was "Active Learning Assisted Optimisation of a Novel Series of Antimalarials".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Emma Grant presented a poster on her research at the EMBL meeting "Expanding the Druggable Proteome", held in Heidelberg, Germany, in February 2020.
Year(s) Of Engagement Activity 2020
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD Student Alfie Wills presented a poster on his research entitled "A selectivity switch in the electrochemical oxidation of 4-methylansiole". The research was presented at the 26th SCI Annual Review Meeting - Catalysis and Enabling Technologies for Synthesis, in London on 4th December 2019.
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Strathclyde/GSK Collaborative PhD student Jessie Tucker gave a poster presentation on her research at the STEM for Britain 2019 Meeting, held at the House of Commons, London, on 13th March 2019. The title of her poster presentation was "The Use of Contemporary Chemoproteomic Techniques in Antimalarial Target Identification".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Strathclyde/GSK Collaborative PhD student Maxime Rouah gave a poster presentation on his research at the Chalres River PhD Poster Competition, held at Charles River Laboratories, Cambridge, UK, on 27th September 2019. The title of his poster presentation was "Discovery of bioorthogonal chemical probes for the cellular imaging and target engagement measurement of inhaled PI3Kd inhibitors".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Jessie Tucker gave a poster presentation on her research at the RSC Chemical Biology Symposium, held in London on 20th May 2019. The title of her poster presentation was "The Use of Contemporary Chemoproteomic Techniques in Antimalarial Target Identification".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Brett Cosgrove gave a poster presentation on his research at the 2nd RSC Anglo-Nordic Medicinal Chemistry Symposium, held in Copenhagen, Denmark, in June 2019. The title of his poster presentation was "The synthesis and evaluation of the physicochemical properties of nitrogen containing 6,5-bicyclic heterocycles".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student James Thompson gave a poster presentation on his research at the 10th EUROPIN Summer School in Drug Discovery, held in Vienna from 16th-20th September 2019. The title of his poster presentation was "Computationally guided SAR exploration of an orally bioavailable template for the avß1 integrin".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Maxime Rouah gave a poster presentation on his research at the RSC Chemical Biology and Bio-Organic Postgraduate Symposium, held in Southampton on the 26th April 2019. The title of his poster presentation was "Discovery of bioorthogonal chemical probes for the cellular imaging and target engagement measurement of inhaled PI3Kd inhibitors".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Strathclyde/GSK Collaborative PhD student Brett Cosgrove gave a poster presentation on his research at the Charles River PhD Poster Competition at Charles River Laboratories, Cambridge, in September 2019. The title of his poster presentation was "Targeting non-cysteine residues selectively in PI4KIIIß using fluorosulfates as covalent warheads".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Lucia Fusani gave a poster presentation on her research at the Structure Based Drug Design Conference(SBDD) , held in Sestri Levante, Italy, from 22nd-26th September 2019.
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Maxime Rouah gave a poster presentation on his research at the Young researcher Symposium 2019, held in Tres Cantos, Spain, on 21st June 2019. The title of his poster presentation was "Discovery of bioorthogonal chemical probes for the cellular imaging and target engagement measurement of inhaled PI3Kd inhibitors".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Emma Grant presented a poster on her research at the GSK-Crick LinkLabs Symposium held in London on the 29th April 2019.
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Emma Grant presented a poster on her research at "RICT 2019 - Interfacing Chemical Biology and Drug Discovery", held in Nantes, France, in July 2019.
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Strathclyde/GSK Collaborative PhD student Oliver Turner gave a poster presentation on his research at the STEM for Britain meeting, held in the Houses of Parliament, London, in March 2019. The title of his poster presentation was "New Hydrogen Atom Transfer Methodologies".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Peter Clark gave a poster presentation on his research at the RSC Organic Division Poster Symposium in December 2019.
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Ross Thomas presented a poster on his research at the 2nd Crick-GSK LinkLabs Symposium, London, on 29th April 2019. The title of the poster presentation was "High-throughput synthesis of PhotoAffinity Bits (PhABits) to study protein-ligand binding".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Sam Holman gave a poster presentation on his research at the RSC Organic Division Poster Competition in London in December 2019. The title of his poster presentation was "Electrochemically Enabled Synthesis of Substituted Isoxazolines".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Oliver Turner gave a poster presentation on his research at the RSC's 26th International symposium: Synthesis in organic chemistry, held at the University of Cambridge from 15th-18th July 2019. The title of his poster presentation was "New Hydrogen Atom Transfer Methodologies".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Oliver Turner gave a poster presentation on his research at the Pacific Symposium on Radical Chemisty, California, in June 2019. The title of his poster presentation was "New Hydrogen Atom Transfer Methodologies".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Emma Grant presented a poster on her research at the SCI Protein-Protein Interactions meeting held in London on the 5th April 2019.
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Brett Cosgrove gave a poster presentation on his research at the GSK Vaccines workshop, held in Siena, Italy, in December 2019. The title of his poster presentation was "Targeting non-cysteine residues selectively in PI4KIIIß using fluorosulfates as covalent warheads".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Holly Bonfield presented a poster on her research at the 26th SCI Annual Review Meeting - Catalysis and Enabling Technologies for Synthesis, held in London on 4th December 2019. The poster was entitled "De Novo Design of a Robust Modular Photochemical Reactor for Optimum Batch and Flow Chemistry"
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Lucia Fusani gave a poster presentation on her research at the Alchemical Free Energy Workshop, held in Germany from 27th-28th May 2019.
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Jessie Tucker gave a poster presentation on her research at the Young Researchers Symposium 2019, held in Tres Cantos, Madrid, on 21st June 2019. The title of her poster presentation was "The Use of Contemporary Chemoproteomic Techniques in Antimalarial Target Identification".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Strathclyde/GSK Collaborative PhD student Oliver Turner gave a poster presentation on his research at the Charles River PhD Poster Competition, held at Charles River Laboratories, Cambridge, in September 2019. The title of his poster presentation was "New Hydrogen Atom Transfer Methodologies".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Jessie Tucker gave a poster presentation on her research at the ChemBiOx symposium, held at Worcester College, Oxford, from 30th - 31st July 2019. The title of her poster presentation was "The Use of Contemporary Chemoproteomic Techniques in Antimalarial Target Identification".
Year(s) Of Engagement Activity 2019
 
Description Conference Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Enrique Bendito-Moll presented a poster on his research at the SCT Young Research Fellows Meeting , held in Paris, France, in February 2019. The title of his poster presentation was "Mechanistic insight insight enables practical, scalable, room temperature N-arylation of N-aryl sulfonamides".
Year(s) Of Engagement Activity 2019
 
Description Invited Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Professor Jonathan Hirst gave an invited talk entitled "Machines Learning Chemistry", at the UKQSAR Autumn Meeting on 26th September 2019, hosted at Sygnature, Nottingham.
Year(s) Of Engagement Activity 2019
URL http://ukqsar.org/wp-content/uploads/2020/01/01-J-Hirst-UK_QSAR_MachinesLearningChemistry.pdf
 
Description Invited talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Strathclyde/GSK Collaborative PhD student Holly Bonfield delivered an invited talk at the Applied Catalysis and Chemical Engineering conference held in Dubai from 8th-1tth April 2019. The title of the talk was "Development of a Commercial Photoreactor System for HTS, Batch and Flow Scale Up Designed for Process Chemists"
Year(s) Of Engagement Activity 2019
 
Description Nottingham Federation of Women's Institutes visit to GSK Centre for Sustainable Chemistry 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Nottingham Federation of Women's Institutes visit to GSK Centre for Sustainable Chemistry, University of Nottingham, Friday 7th February 2020 - half day event to over 50 delegates featuring talks on sustainable chemistry (Nick Bennett, Nottingham) and sustainable discovery/production of medicines (Helen Sneddon, GSK).
Year(s) Of Engagement Activity 2020
 
Description Oral Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Strathclyde/GSK Collaborative PhD student Hannah Davies gave an oral presentation at the University of Oxford Career Presentation for Undergraduate Chemists and Biochemists, at the University of Oxford on 30th October 2019. The title of her presentation was "A Career as a Medicinal Chemist: Making Drugs for a Living".
Year(s) Of Engagement Activity 2019
 
Description Oral Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Strathclyde/GSK Collaborative PhD student Hannah Davies gave an oral presentation at the SCI "You're Hired" conference in Birmingham on 27th November 2019. The title of her presentation was "A Career as a Medicinal Chemist: Making Drugs for a Living".
Year(s) Of Engagement Activity 2019
 
Description Oral Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Strathclyde/GSK Collaborative PhD student Katherine Macfarlane give an oral presentation to members of EPSRC on 1st May 2019. The presentation was entitled "Heterobifunctional Molecules".
Year(s) Of Engagement Activity 2019