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Fast 3D Super-Resolution Ultrasound Imaging Through Acoustic Activation and Deactivation of Nanodroplets

Lead Research Organisation: University of Oxford
Department Name: Engineering Science

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Bau L (2024) Predicting the spontaneous vaporisation of superheated perfluorocarbon droplets in The Journal of the Acoustical Society of America

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Bau L (2023) Theoretical and experimental investigation of the vaporisation of superheated perfluorocarbon droplets in The Journal of the Acoustical Society of America

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Ovenden N (2024) Non-equilibrium activation dynamics of superheated phase-change contrast agents in The Journal of the Acoustical Society of America

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Riemer K (2022) Fast and selective super-resolution ultrasound in vivo with sono-switchable nanodroplets

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Riemer K (2023) Fast and Selective Super-Resolution Ultrasound In Vivo With Acoustically Activated Nanodroplets. in IEEE transactions on medical imaging

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Riemer K (2024) 3D Acoustic Wave Sparsely Activated Localization Microscopy With Phase Change Contrast Agents in Investigative Radiology

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Taylor L (2024) Simultaneous plane-wave and ultra high-speed imaging of acoustic droplet vaporization in The Journal of the Acoustical Society of America

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Wang B (2022) Comparison of localization methods for 3D Super-Resolution Ultrasound Imaging

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Wu Q (2024) Challenges in classifying cavitation: Correlating high-speed optical imaging and passive acoustic mapping of cavitation dynamics in The Journal of the Acoustical Society of America

 
Description Through a combination of experiments and mathematical modelling we have established a means of predicting the stability of the nanoparticles used in this method that can be utilised for both imaging and therapy. This has enabled us to create new formulations that are safer and more effective. We have demonstrated real time, three dimensional imaging of microvessels in both tissue phantoms and live animal models.
Exploitation Route Our findings should help clinicians employing these types of nanoparticle to do so more safely and ultimately use them more effectively for both imaging and therapeutic delivery.
Sectors Healthcare

Pharmaceuticals and Medical Biotechnology
URL https://www.echocontrast.nl/wp-uploads/archive/Abstractbook-28th-ESUCI-2023.pdf?_gl=1*588epe*_up*MQ..*_ga*NjQyNjcxMjE1LjE2Nzc5Mzc4NDc.*_ga_36DBV8ZXLX*MTY3NzkzNzg0Ny4xLjEuMTY3NzkzNzg1My4wLjAuMA..