Process Control and Novel Materials for the Reactive Jet Impingement Process
Lead Research Organisation:
Newcastle University
Department Name: Sch of Engineering
Abstract
Biofabrication techniques are used to process natural and synthetic biomaterials, for example including cells, proteins and drugs, in order to create living, tissue engineered structures. These structures are being used to research the development of new drugs and cell-based therapies for a wide range of medical conditions.
This research proposal focuses on a new 3D printing technique called Reactive Jet Impingement (ReJI) which can be used for biofabrication. The ReJI technique has some advantages over existing techniques in terms of the number of cells it can deposit within a certain volume, and in terms of the range of the materials and shapes which it can print on.
The research programme will focus on three things:
(i) Improving the technology, by developing a computational model of the process to support and inform experimental studies, and through scaling up the technology in terms of print capability.
(ii) Extending the range of materials which can be processed using the technology.
(iii) Applying the technology to the development of clinically relevant tissue models for two selected application areas in drug testing for liver cancer and cardiac tissue engineering.
This research proposal focuses on a new 3D printing technique called Reactive Jet Impingement (ReJI) which can be used for biofabrication. The ReJI technique has some advantages over existing techniques in terms of the number of cells it can deposit within a certain volume, and in terms of the range of the materials and shapes which it can print on.
The research programme will focus on three things:
(i) Improving the technology, by developing a computational model of the process to support and inform experimental studies, and through scaling up the technology in terms of print capability.
(ii) Extending the range of materials which can be processed using the technology.
(iii) Applying the technology to the development of clinically relevant tissue models for two selected application areas in drug testing for liver cancer and cardiac tissue engineering.
Organisations
- Newcastle University (Lead Research Organisation)
- REGEMAT 3D (Collaboration)
- Bundeswehr University Munich (Collaboration)
- FIBROFIND LTD (Collaboration)
- Lee Products Ltd (Project Partner)
- Fibrofind (Project Partner)
- Biogelx Ltd (Project Partner)
- REGEMAT 3D SL (Project Partner)
- Santorini Scientific (Project Partner)
Publications

Bowes A
(2024)
Bioprinted High-Cell-Density Laminar Scaffolds Stimulate Extracellular Matrix Production in Osteochondral Co-Cultures
in International Journal of Molecular Sciences

Ruiz-Gutiérrez É
(2024)
Physically consistent modelling of surface tension forces in the Volume-of-Fluid method for three or more phases
in Journal of Computational Physics

Ruiz-Gutiérrez É
(2023)
Analysis and optimisation of mixing in binary droplet collisions
in Journal of Fluid Mechanics
Description | Henry Royce Industrial Collaboration Programme |
Amount | £99,165 (GBP) |
Funding ID | ICP317 |
Organisation | Henry Royce Institute |
Sector | Academic/University |
Country | United Kingdom |
Start | 09/2023 |
End | 02/2024 |
Description | REBORN: Remodelling of the Infarcted Heart: Piezoelectric Multifunctional Patch Enabling the Sequential Release of Therapeutic Factors |
Amount | € 5,000,000 (EUR) |
Funding ID | 101091852 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 01/2023 |
End | 12/2026 |
Description | Fibrofind |
Organisation | FibroFind Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | Collaboration on model of liver cancer |
Collaborator Contribution | Collaboration on model of liver cancer |
Impact | No outcomes yet Multi-disciplinary: engineering and life sciences |
Start Year | 2021 |
Description | Regemat3D |
Organisation | REGEMAT 3D |
Country | Spain |
Sector | Private |
PI Contribution | Collaboration on bioprinting technology |
Collaborator Contribution | Collaboration on bioprinting technology |
Impact | No outcomes yet Multi-disciplinary: engineering and life sciences |
Start Year | 2021 |
Description | UniBW |
Organisation | Bundeswehr University Munich |
Country | Germany |
Sector | Academic/University |
PI Contribution | Collaboration on CFD code development |
Collaborator Contribution | Collaboration on CFD code development |
Impact | No outcomes yet Focusses on computational fluid dynamics |
Start Year | 2021 |
Company Name | Jetbio Ltd |
Description | |
Year Established | 2023 |
Impact | None to date |