UltraSOuNd-controlled drug release from Antimicrobial particles for denTAl tissues (SONATA)
Lead Research Organisation:
University College London
Department Name: Chemical Engineering
Abstract
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Organisations
Publications
Hossein F
(2021)
Application of acoustic techniques to fluid-particle systems - A review
in Chemical Engineering Research and Design
Koulogiannis A
(2024)
Ultrasonic irrigation flows in root canals: effects of ultrasound power and file insertion depth
in Scientific Reports
Meridiano G
(2022)
Scaling law for the viscoelasticity-induced particle migration in stirred vessels
in Journal of Non-Newtonian Fluid Mechanics
| Description | The aim of the project is to develop novel nanoparticles in dental treatment for localised delivery and release of antibacterial agents assisted by ultrasound. We will study the particle delivery and drug release in microfluidic channels mimicking the dental tubules and the root canals and will employ hydrogels as surrogate bacterial film models. We have identified suitable nanoparticles acting as drug carriers with fluorescent properties which enable imaging studies of their flow and of the drug release. We have also developed the microfluidic channels with geometries resembling root canals and tubules. We have studied the effects of ultrasound on the flows in this geometries. In addition, appropriate hydrogels with similar theological properties to the biofilms have been identified and applied to the channels. |
| Exploitation Route | The following project outcomes can be taken forward -the results on biofilm treatment by ultrasound assisted drug delivery with nanoparticles will benefit researchers and practitioners in dentistry; - the development of the particles will provide a new range of biomaterials with entrapped drug designs which can tackle other diseases of global interest where local drug delivery is relevant to treatment, such as cancer; -the effect of ultrasound on the transport of the particles in confined geometries will be benefit researchers in other areas such as catalysis in flow reactors; -the development of the microfluidic platform and of the methodologies for the study of particle flows can be taken forward by researchers using microfluidic channels for chemical analysis or as models of complex porous materials (including membranes, soil). |
| Sectors | Agriculture Food and Drink Healthcare Manufacturing including Industrial Biotechology |
| Description | Oral presentation at the BioMedEng22 (Experimental Study of Ultrasound Induced Flows for Biofilm Removal Optimization, A. Koulogiannis, G. Meridiano, P. Angeli, S. Balabani) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | An oral presentation about the research conducted for the project so far was made for many students and academics who participated in the conference. That sparked questions and discussion about our results as well as the future research plans of the project. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://biomedeng.org/biomedeng22/ |
| Description | Poster presentation at the ChemEngDayUK 2022 (Ultrasound induced flows and transport phenomena in confined dentine models, A. Koulogiannis, S. Balabani and P. Angeli ) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | The poster was presented to many students and academics who participated on the conference. That sparked questions and discussion about further plans of the project and future research on the field. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.ucl.ac.uk/chemical-engineering/chemengdayuk-2022 |