Solving Maxwell's equations using deep learning
Lead Research Organisation:
UNIVERSITY COLLEGE LONDON
Department Name: Medical Physics and Biomedical Eng
Abstract
Radio waves, light and micro waves are all examples of electromagnetic waves and they are essential to a myriad of technologies that we interact with on a daily basis. Much effort has been devoted to methods for simulating how electromagnetic waves interact with matter. For example, understanding how radio waves propagate through the atmosphere has been important to the development of satellite communications. Simulations have also been important to develop understanding of how the radiation emitted by mobile phones interacts with the human body, for example. There are in fact many examples of where the propagation of electromagnetic waves through heterogeneous media is important.
These simulation technique have recently been employed in biomedical optical imaging to aid in the interpretation of optical coherence tomography (OCT) images. OCT is a three-dimensional imaging technique which is now routinely available at high street opticians. It is highly effective for detecting a range of retinal diseases at an early stage. Performing OCT imaging as part of a routine optician examination is excellent for improving early detection of disease, however, there are simply not enough ophthalmologists to analyse these images. One excellent approach to solving this problem uses artificial intelligence, trained using historical OCT images which have already been analysed by ophthalmologists, to analyse new images. We propose to enrich this approach by using computers to simulate OCT images of the retina to improve the capabilities of the artificial intelligence system. The advantage of this approach is that, unlike real OCT images, the underlying condition of the retina is known precisely for simulated images.
There is currently a problem which prevents us from simulating realistic OCT images of the retina, which is that these simulations take far too long to compute. These simulations take so long because of the time it takes to simulate how light travels in the retina. We plan to significantly speed up this calculation using artificial intelligence, in particular, deep neural networks. Developing a deep neural network approach to simulate light propagation will enable us to calculate simulated OCT of the retina for retinal structures which are of clinical importance. This will help to improve the analysis of OCT images. This fast method of simulating light propagation will be applicable to an immense range of applications where the propagation of electromagnetic waves is important.
These simulation technique have recently been employed in biomedical optical imaging to aid in the interpretation of optical coherence tomography (OCT) images. OCT is a three-dimensional imaging technique which is now routinely available at high street opticians. It is highly effective for detecting a range of retinal diseases at an early stage. Performing OCT imaging as part of a routine optician examination is excellent for improving early detection of disease, however, there are simply not enough ophthalmologists to analyse these images. One excellent approach to solving this problem uses artificial intelligence, trained using historical OCT images which have already been analysed by ophthalmologists, to analyse new images. We propose to enrich this approach by using computers to simulate OCT images of the retina to improve the capabilities of the artificial intelligence system. The advantage of this approach is that, unlike real OCT images, the underlying condition of the retina is known precisely for simulated images.
There is currently a problem which prevents us from simulating realistic OCT images of the retina, which is that these simulations take far too long to compute. These simulations take so long because of the time it takes to simulate how light travels in the retina. We plan to significantly speed up this calculation using artificial intelligence, in particular, deep neural networks. Developing a deep neural network approach to simulate light propagation will enable us to calculate simulated OCT of the retina for retinal structures which are of clinical importance. This will help to improve the analysis of OCT images. This fast method of simulating light propagation will be applicable to an immense range of applications where the propagation of electromagnetic waves is important.
Organisations
Publications

Macdonald CM
(2023)
On the inverse problem in optical coherence tomography.
in Scientific reports

Mazzolani A
(2022)
Application of a Taylor series approximation to the Debye-Wolf integral in time-domain numerical electromagnetic simulations.
in Journal of the Optical Society of America. A, Optics, image science, and vision
Description | We have demonstrated that it is possible to use machine learning to calculate how light propagates through a medium. It is generally very difficult to calculate how light propagates through a medium, requiring powerful computers and a lot of computation time. We have found that we can achieve this by using machine learning, where a software tool called a neural network is trained to solve this problem. |
Exploitation Route | This problem turned out to be more challenging than anticipated. We discovered intrinsic difficulties with training the network. We have resolved this challenge, however, we will need to apply for further funding to complete the aims of the project. |
Sectors | Aerospace Defence and Marine Digital/Communication/Information Technologies (including Software) Pharmaceuticals and Medical Biotechnology |
Description | Optimising light-tissue interaction to enable multiscale imaging of neuronal dynamics deep within the neocortex |
Amount | £1,916,173 (GBP) |
Funding ID | EP/W024039/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2022 |
End | 03/2025 |
Description | Research Fellows Enhanced Research Expenses 2021 |
Amount | £169,800 (GBP) |
Funding ID | RF\ERE\210307 |
Organisation | The Royal Society |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 12/2021 |
End | 11/2023 |
Title | Time Domain Maxwell Solver (TDMS) |
Description | TDMS, the Time Domain Maxwell Solver, is a hybrid C++ and MATLAB tool for solving Maxwell's equations to simulate light propagation through a medium. |
Type Of Material | Computer model/algorithm |
Year Produced | 2022 |
Provided To Others? | Yes |
Impact | No results have been reported yet |
URL | https://github.com/UCL/TDMS |
Title | TDMS - The Time-Domain Maxwell Solver |
Description | Minor (but very important) fix to the example script so that it now runs by @willGraham01 as in #320. Other minor fixes and doc improvements pulled from
main . Full Changelog: https://github.com/UCL/TDMS/compare/v1.0.0...v1.0.1 |
Type Of Technology | Software |
Year Produced | 2023 |
Open Source License? | Yes |
Impact | The release of this software has contributed to me being asked to give an invited talk at the Optica Biophotonics Congress in April 2024. This is a prestigious invited talk reaching an audience of international experts in the field. The software has also enabled early stage collaborations with: - A/Prof Vivek Srinivsan, NYU Grossman School of Medicine, USA - Prof Rainer Leitgeb, Medical University Vienna, Austria - Prof Peter Andersen, Danmarks Tekniske Universitet, Denmark - Prof Maciej, Nicolaus Copernicus University, Poland These collaborations are all aimed at using TDMS to make new discoveries in biomedical imaging. |
URL | https://zenodo.org/record/7950603 |
Description | Podcast recorded by international professional body and published to an international audience |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | lluminated by Institute of Electrical and Electronic Engineers (IEEE) Photonics is a podcast series that shines a light on hot topics in photonics, and the subject matter experts advancing technology forward. This podcast is aimed at all researchers engaged in biomedical optics research, from undergraduate up to Professor. The podcast leverages the reach of the IEEE Photonics Society to reach an international audience. I acted as the moderator for a podcast on computational optics, with the guest researcher Prof Aydogan Ozcan. |
Year(s) Of Engagement Activity | 2023 |
URL | https://ieeephotonics.buzzsprout.com/1345429/14496931-pioneering-biomedical-imaging-with-computation... |