📣 Help Shape the Future of UKRI's Gateway to Research (GtR)

We're improving UKRI's Gateway to Research and are seeking your input! If you would be interested in being interviewed about the improvements we're making and to have your say about how we can make GtR more user-friendly, impactful, and effective for the Research and Innovation community, please email gateway@ukri.org.

NeuroMod+: Co-creation for next-generation neuromodulation therapeutics

Lead Research Organisation: Imperial College London
Department Name: Bioengineering

Abstract

The Neuromod+ network will represent UK research, industry, clinical and patient communities, working together to address the challenge of minimally invasive treatments for brain disorders. Increasingly, people suffer from debilitating and intractable neurological conditions, including neurodegenerative diseases and mental health disorders. Neurotechnology is playing an increasingly important part in solving these problems, leading to recent bioelectronic treatments for depression and dementia. However, the invasiveness of existing approaches limits their overall impact. Neuromod+ will bring together neurotechnology stakeholders to focus on the co-creation of next generation, minimally invasive brain stimulation technologies. The network will focus on transformative research, new collaborations, and facilitating responsible innovation, partnering with bioethicists and policy makers. As broadening the accessibility of brain modification technology my lead to unintended consequences, considering the ethical and societal implications of these technological development is of the utmost importance, and thus we will build in bioethics research as a core network activity. The activities of NEUROMOD+ will have global impact, consolidating the growing role of UK neurotechnology sector.

Organisations

Publications

10 25 50

publication icon
Atkinson-Clement C (2025) Delay- and Pressure-Dependent Neuromodulatory Effects of Transcranial Ultrasound Stimulation. in Neuromodulation : journal of the International Neuromodulation Society

publication icon
Atkinson-Clement C (2025) Optimizing Transcranial Focused Ultrasound Stimulation: An Open-source Tool for Precise Targeting. in Neuromodulation : journal of the International Neuromodulation Society

publication icon
Atkinson-Clement C (2025) Neuromodulation perception by the general public. in Scientific reports

publication icon
Pascual-Valdunciel A (2024) Frequency-Selective Suppression of Essential Tremor via Transcutaneous Spinal Cord Stimulation. in Movement disorders : official journal of the Movement Disorder Society

 
Title TMS, TES, and their combination for use in depression - lived experience perspectives 
Description Three videos made with people with lived experience of depression, illustrating TMS, TES, and their combination, for use in projects around acceptability of neuromodulation approaches 
Type Of Art Film/Video/Animation 
Year Produced 2025 
Impact None yet, but the videos will be available for use in projects around acceptability of neuromodulation approaches 
 
Description We have established a network of multidisciplinary neurotechnology stakeholders, which represents a critical mass of experts in the field across different sectors (including academic, clinical, PPI, industry and charity sectors). Network seed funding awards and activities have enabled:
- sharing of expertise and knowledge across sectors and multiple new collaborations involving different stakeholders
- identification of priorities and unmet clinical needs in the area, and generation of new research question/ideas
- development of an online database of network members to aid collaboration
- enhancement of support and development of new minimally invasive neuromodulation technologies
- support for development and training of ECR members working in neuromodulation
- development of new published guidelines and resources on PPI in neurotechnologies specific to neurotechnologies
- establishment of a UK symposium on Neuromodulation and Neurotechnology (hosted jointly with CloseNIT network) bringing together neurotechnology stakeholders for academic, industry and PPI discussions. We plan for this to become an annual event (outliving the network funding) to continue to stimulate knowledge exchange and further developments in the field
- collation of views via our survey on ethical aspects of neurotechnologies, leading in to cross-network collaborative discussions on ethics
- follow-on funding for a £2.2M MRC programme grant in Closed-loop non-invasive stimulation for improving brain and mental health
Exploitation Route We anticipate that resources and guidelines on PPI in neurotechnologies and ethics in neurotechnology developed through this project will be used by future researchers to enable them to incorporate PPI and ethics more successfully into future activities.
An annual symposium will continue to bring together academic researchers, clinicians, charity, industry & PPI reps working in the field to retain critical mass, and stimulate discussion and further development of technologies.
Sectors Communities and Social Services/Policy

Education

Healthcare

Manufacturing

including Industrial Biotechology

Pharmaceuticals and Medical Biotechnology

URL https://neuromodplus.org
 
Description Closed-loop non-invasive stimulation for improving brain and mental health
Amount £2,200,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2025 
 
Description Imperial College strategic seed funding for international partnerships in biosciences and biotechnology: Imperial-RIKEN collaboration on the dynamic engram
Amount £49,008 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 02/2024 
End 09/2025
 
Description International centre to centre research collaborations: UK Japan collaboration on mesoscopic multiphoton neuroimaging technology
Amount £50,142 (GBP)
Funding ID EP/Y020316/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 01/2024 
End 12/2025
 
Description Minimally Invasive Multiplexed Temporal Interference Brain Stimulation Network
Amount £4,140,515 (GBP)
Organisation Advanced Research and Innovation Agency (ARIA) 
Sector Public
Country United Kingdom
Start 01/2025 
End 12/2028
 
Description Neurodegeneration Challenge Network (NDCN) Collaborative Pairs Pilot Project Awards
Amount $200,000 (USD)
Organisation Chan Zuckerberg Initiative 
Sector Private
Country United States
Start 03/2024 
End 09/2025
 
Description Regenerative Electroactive Scaffolds for Circuit Unification via Electromodulation
Amount £3,723,213 (GBP)
Organisation Advanced Research and Innovation Agency (ARIA) 
Sector Public
Country United Kingdom
Start 01/2025 
End 12/2028
 
Description Advances in Neuromodulation workshop collaboration with University of Nottingham and Parkinson's UK 
Organisation Parkinson's UK
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Organisation of workshop on Advances in non-invasive brain stimulation: exploring the potential for therapeutic application for PD, including talks from network members
Collaborator Contribution Co-funding of workshop and attendance at workshop by Parkinson's UK representatives, including talks from members.
Impact Workshop held in March 2025, bringing together clinicians, researchers, individuals with lived experience of PD, to and discuss and share current best practice in relation to advances in non-invasive brain stimulation that are, or could be, relevant for the treatment of motor and non-motor symptoms of PD. The meeting aim is to develop new research consortia with an interest in developing non-invasive brain stimulation for PD, to review barriers to using non-invasive stimulation for brain health conditions. This could lead to the preparation of a discussion/consensus article for publication where appropriate and the generation of one or more research grant applications.
Start Year 2025
 
Description Advances in Neuromodulation workshop collaboration with University of Nottingham and Parkinson's UK 
Organisation University of Nottingham
Department School of Psychology Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Organisation of workshop on Advances in non-invasive brain stimulation: exploring the potential for therapeutic application for PD, including talks from network members
Collaborator Contribution Co-funding of workshop and attendance at workshop by Parkinson's UK representatives, including talks from members.
Impact Workshop held in March 2025, bringing together clinicians, researchers, individuals with lived experience of PD, to and discuss and share current best practice in relation to advances in non-invasive brain stimulation that are, or could be, relevant for the treatment of motor and non-motor symptoms of PD. The meeting aim is to develop new research consortia with an interest in developing non-invasive brain stimulation for PD, to review barriers to using non-invasive stimulation for brain health conditions. This could lead to the preparation of a discussion/consensus article for publication where appropriate and the generation of one or more research grant applications.
Start Year 2025
 
Description Beshoy Agayby: Neuromod+ ECR funding for placements to Imperial College London and Newcastle University 
Organisation Newcastle University
Department Biosciences Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ award for £1400 to enable research collaborations
Collaborator Contribution This project aims to advance closed-loop neural interface technology using auditory stimulation. One key component is acquisition of the electrophysiological signals needed to trigger the auditory stimulation. To achieve this, we are developing a wireless electrophysiology system in close collaboration with Imperial College London The second key component is experiments taking part at Newcastle University which aim to test a) the function of the device b) the efficacy of using sound to modulate neural activity.
Impact See placements section
Start Year 2024
 
Description Bhushan Thakkar: Neuromod+ ECR funding for placement to Aalborg University 
Organisation Aalborg University
Country Denmark 
Sector Academic/University 
PI Contribution Neuromod+ funding of £2000 to enable research placement
Collaborator Contribution Awardee: Bhushan Thakkar, Postdoctoral Research Fellow, Division of Population Health and Genomics, School of Medicine, University of Dundee. Host PI: Thomas Graven-Nielsen, Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark Objectives: To foster new collaborative relationships between the University of Dundee and CNAP to optimise the use of brain stimulation techniques like TMS and tDCS to improve understanding of the neural mechanisms that can explain the outcomes of these brain stimulation techniques to improve technical knowledge in using EEG and tDCS to optimise and personalise the use of rTMS in people with NP and in healthy volunteers
Impact See placements section
Start Year 2024
 
Description Bhushan Thakkar: Neuromod+ ECR funding for placement to Aalborg University 
Organisation University of Dundee
Department School of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ funding of £2000 to enable research placement
Collaborator Contribution Awardee: Bhushan Thakkar, Postdoctoral Research Fellow, Division of Population Health and Genomics, School of Medicine, University of Dundee. Host PI: Thomas Graven-Nielsen, Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark Objectives: To foster new collaborative relationships between the University of Dundee and CNAP to optimise the use of brain stimulation techniques like TMS and tDCS to improve understanding of the neural mechanisms that can explain the outcomes of these brain stimulation techniques to improve technical knowledge in using EEG and tDCS to optimise and personalise the use of rTMS in people with NP and in healthy volunteers
Impact See placements section
Start Year 2024
 
Description Bridging the Gap: Promoting Acceptance and Inclusivity of Non-Invasive Neurotechnology in Ethnic Minority Communities 
Organisation Israac Somali Community & Cultural Association
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £11,590 granted
Collaborator Contribution The team will conduct a feasibility study on Promoting Acceptance and Inclusivity of Non-Invasive Neurotechnology in Ethnic Minority Communities, using funds from the network. To foster acceptance and inclusivity of non-invasive neurotechnology in African ethnic minority communities, the team will co-create videos featuring interviews with end users and clinicians. This video will highlight the benefits and address the unique needs and concerns of these communities. Through personal stories and expert insights, we aim to build trust and demonstrate the positive impact of neurotechnology on health and well-being, promoting its acceptance and inclusivity. Dr. Arvaneh is an expert in non-invasive BCI and brain stimulation, and will lead the project. Dr. Blackburn is a Consultant Neurologist providing insights on neuroscience and neurological diseases potentially treatable by non-invasive neurotechnology. Lise Sproson is Patient and Public Involvement Lead, specializing in designing and delivering meaningful user-centred PPI workshops. Ismail Yussuf is Operations Manager at Israac, facilitating access to the Somali community and organizing one-on-one interviews. Sahra Abdi and Muse Jama are D4D Community Research Associates and Israac Advice and Support Workers, assisting with interviews and managing reimbursement vouchers. Yaasiin Hersi is Israac Advice and Support Worker, helping Brettincity with transcription and subtitles for the video. Mohammed Mohamed and Mian Kou are University of Sheffield researchers specializing in non-invasive brain stimulation and imaging, aiding in video planning and dissemination. Brett Chapman is an award-winning filmmaker from Brettincity, focusing on stories about individuals and small communities, and will handle the video production.
Impact The collaboration is multidisciplinary and combines engineering, clinical neurology, and patient and public involvement. No outcomes yet.
Start Year 2024
 
Description Bridging the Gap: Promoting Acceptance and Inclusivity of Non-Invasive Neurotechnology in Ethnic Minority Communities 
Organisation Sheffield Teaching Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Neuromod+ feasibility study funding award of £11,590 granted
Collaborator Contribution The team will conduct a feasibility study on Promoting Acceptance and Inclusivity of Non-Invasive Neurotechnology in Ethnic Minority Communities, using funds from the network. To foster acceptance and inclusivity of non-invasive neurotechnology in African ethnic minority communities, the team will co-create videos featuring interviews with end users and clinicians. This video will highlight the benefits and address the unique needs and concerns of these communities. Through personal stories and expert insights, we aim to build trust and demonstrate the positive impact of neurotechnology on health and well-being, promoting its acceptance and inclusivity. Dr. Arvaneh is an expert in non-invasive BCI and brain stimulation, and will lead the project. Dr. Blackburn is a Consultant Neurologist providing insights on neuroscience and neurological diseases potentially treatable by non-invasive neurotechnology. Lise Sproson is Patient and Public Involvement Lead, specializing in designing and delivering meaningful user-centred PPI workshops. Ismail Yussuf is Operations Manager at Israac, facilitating access to the Somali community and organizing one-on-one interviews. Sahra Abdi and Muse Jama are D4D Community Research Associates and Israac Advice and Support Workers, assisting with interviews and managing reimbursement vouchers. Yaasiin Hersi is Israac Advice and Support Worker, helping Brettincity with transcription and subtitles for the video. Mohammed Mohamed and Mian Kou are University of Sheffield researchers specializing in non-invasive brain stimulation and imaging, aiding in video planning and dissemination. Brett Chapman is an award-winning filmmaker from Brettincity, focusing on stories about individuals and small communities, and will handle the video production.
Impact The collaboration is multidisciplinary and combines engineering, clinical neurology, and patient and public involvement. No outcomes yet.
Start Year 2024
 
Description Bridging the Gap: Promoting Acceptance and Inclusivity of Non-Invasive Neurotechnology in Ethnic Minority Communities 
Organisation University of Sheffield
Department Automatic Control and Systems Engineering
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £11,590 granted
Collaborator Contribution The team will conduct a feasibility study on Promoting Acceptance and Inclusivity of Non-Invasive Neurotechnology in Ethnic Minority Communities, using funds from the network. To foster acceptance and inclusivity of non-invasive neurotechnology in African ethnic minority communities, the team will co-create videos featuring interviews with end users and clinicians. This video will highlight the benefits and address the unique needs and concerns of these communities. Through personal stories and expert insights, we aim to build trust and demonstrate the positive impact of neurotechnology on health and well-being, promoting its acceptance and inclusivity. Dr. Arvaneh is an expert in non-invasive BCI and brain stimulation, and will lead the project. Dr. Blackburn is a Consultant Neurologist providing insights on neuroscience and neurological diseases potentially treatable by non-invasive neurotechnology. Lise Sproson is Patient and Public Involvement Lead, specializing in designing and delivering meaningful user-centred PPI workshops. Ismail Yussuf is Operations Manager at Israac, facilitating access to the Somali community and organizing one-on-one interviews. Sahra Abdi and Muse Jama are D4D Community Research Associates and Israac Advice and Support Workers, assisting with interviews and managing reimbursement vouchers. Yaasiin Hersi is Israac Advice and Support Worker, helping Brettincity with transcription and subtitles for the video. Mohammed Mohamed and Mian Kou are University of Sheffield researchers specializing in non-invasive brain stimulation and imaging, aiding in video planning and dissemination. Brett Chapman is an award-winning filmmaker from Brettincity, focusing on stories about individuals and small communities, and will handle the video production.
Impact The collaboration is multidisciplinary and combines engineering, clinical neurology, and patient and public involvement. No outcomes yet.
Start Year 2024
 
Description Bridging the Gap: Promoting Acceptance and Inclusivity of Non-Invasive Neurotechnology in Ethnic Minority Communities 
Organisation University of Sheffield
Department Department of Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £11,590 granted
Collaborator Contribution The team will conduct a feasibility study on Promoting Acceptance and Inclusivity of Non-Invasive Neurotechnology in Ethnic Minority Communities, using funds from the network. To foster acceptance and inclusivity of non-invasive neurotechnology in African ethnic minority communities, the team will co-create videos featuring interviews with end users and clinicians. This video will highlight the benefits and address the unique needs and concerns of these communities. Through personal stories and expert insights, we aim to build trust and demonstrate the positive impact of neurotechnology on health and well-being, promoting its acceptance and inclusivity. Dr. Arvaneh is an expert in non-invasive BCI and brain stimulation, and will lead the project. Dr. Blackburn is a Consultant Neurologist providing insights on neuroscience and neurological diseases potentially treatable by non-invasive neurotechnology. Lise Sproson is Patient and Public Involvement Lead, specializing in designing and delivering meaningful user-centred PPI workshops. Ismail Yussuf is Operations Manager at Israac, facilitating access to the Somali community and organizing one-on-one interviews. Sahra Abdi and Muse Jama are D4D Community Research Associates and Israac Advice and Support Workers, assisting with interviews and managing reimbursement vouchers. Yaasiin Hersi is Israac Advice and Support Worker, helping Brettincity with transcription and subtitles for the video. Mohammed Mohamed and Mian Kou are University of Sheffield researchers specializing in non-invasive brain stimulation and imaging, aiding in video planning and dissemination. Brett Chapman is an award-winning filmmaker from Brettincity, focusing on stories about individuals and small communities, and will handle the video production.
Impact The collaboration is multidisciplinary and combines engineering, clinical neurology, and patient and public involvement. No outcomes yet.
Start Year 2024
 
Description Characterization of the clinical and neuromodulatory effects of transcutaneous Spinal Cord Stimulation in Essential Tremor. Dario Farina, Alejandro Pascual Valdunciel, Anna Latorre, Kailash Bhatia 
Organisation Imperial College London
Department Department of Bioengineering
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £79,406.38 granted
Collaborator Contribution The team will conduct a feasibility study on Characterization of the clinical and neuromodulatory effects of transcutaneous Spinal Cord Stimulation in Essential Tremor, using funds from the network. Prof. Farina (ICL) with large experience in neural interfacing will lead the coordination of the project, assuring successful fulfilment of the goals. Dr. Latorre (UCL) will lead the clinical research regarding experimentation with patients, which will also be supported by Prof. Bhatia. Dr. Pascual will lead the technical implementation of the experimental protocols, based on his experience in closed-loop tremor reduction systems. All the members will be actively involved in the design of the studies and the interpretation of the results. The teams at ICL and UCL have collected preliminary data that prove the feasibility of the project.
Impact The collaboration is multidisciplinary and combines bioengineering/neural interfacing (ICL team) with neurological and clinical expertise (UCL team). Outputs: - Publication: "Frequency-Selective Suppression of Essential Tremor via Transcutaneous Spinal Cord Stimulation" DOI: 10.1002/mds.29966. - Collaboration: Throughout the year, our team and the partner team collaborated on a weekly basis to run experiments together. This close and consistent collaboration led to excellent outcomes, including significant mutual learning, the development of new ideas for future projects, and overall great teamwork. The collaboration was formalised through an agreement facilitated by the award, ensuring a strong foundation for our partnership. - Engagement activities: - Interview on the Movement Disorder Society podcast - Invited talk at UK Symposium on Neuromodulation & Neurotechnology - Invited talk in special session at International Conference on Neurorehabilitation 2024. - Datasets: We collected new data from human participants, specifically patients with essential tremor. This dataset includes recordings of tremor activity during transcutaneous spinal cord electrical stimulation, capturing variations in tremor patterns with different stimulation parameters. The dataset is currently published and may be made available to others upon request. The dataset provides valuable insights into how spinal cord stimulation affects tremor dynamics, offering potential for developing personalised treatments for essential tremor. DOI: 10.1002/mds.29966 - Medical products, clinical trials etc: Our pilot study explored the use of transcutaneous spinal cord stimulation (tSCS) as a potential therapeutic intervention for essential tremor (ET). We applied tSCS at different frequencies of stimulation to assess its efficacy in modulating tremor activity. this was an initial pilot study to evaluate feasibility and gather preliminary data. Notable Impacts: The study generated significant interest as a potential non-invasive treatment for ET, warranting further investigation. Notably, tSCS delivered at the subject's tremor frequency showed promise in alleviating postural tremor in patients with ET. - Awards & recognition: - Our work was accepted as a late-breaking abstract at the Movement Disorder Society (MDS) Congress 2024 in Philadelphia. This highlights the significance and timeliness of our findings within the field. - Anna Latorre was personally invited to discuss the research on the Movement Disorder Society Podcast, providing an opportunity to share findings with a global audience and contribute to the scientific discourse in the movement disorders community.
Start Year 2023
 
Description Characterization of the clinical and neuromodulatory effects of transcutaneous Spinal Cord Stimulation in Essential Tremor. Dario Farina, Alejandro Pascual Valdunciel, Anna Latorre, Kailash Bhatia 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £79,406.38 granted
Collaborator Contribution The team will conduct a feasibility study on Characterization of the clinical and neuromodulatory effects of transcutaneous Spinal Cord Stimulation in Essential Tremor, using funds from the network. Prof. Farina (ICL) with large experience in neural interfacing will lead the coordination of the project, assuring successful fulfilment of the goals. Dr. Latorre (UCL) will lead the clinical research regarding experimentation with patients, which will also be supported by Prof. Bhatia. Dr. Pascual will lead the technical implementation of the experimental protocols, based on his experience in closed-loop tremor reduction systems. All the members will be actively involved in the design of the studies and the interpretation of the results. The teams at ICL and UCL have collected preliminary data that prove the feasibility of the project.
Impact The collaboration is multidisciplinary and combines bioengineering/neural interfacing (ICL team) with neurological and clinical expertise (UCL team). Outputs: - Publication: "Frequency-Selective Suppression of Essential Tremor via Transcutaneous Spinal Cord Stimulation" DOI: 10.1002/mds.29966. - Collaboration: Throughout the year, our team and the partner team collaborated on a weekly basis to run experiments together. This close and consistent collaboration led to excellent outcomes, including significant mutual learning, the development of new ideas for future projects, and overall great teamwork. The collaboration was formalised through an agreement facilitated by the award, ensuring a strong foundation for our partnership. - Engagement activities: - Interview on the Movement Disorder Society podcast - Invited talk at UK Symposium on Neuromodulation & Neurotechnology - Invited talk in special session at International Conference on Neurorehabilitation 2024. - Datasets: We collected new data from human participants, specifically patients with essential tremor. This dataset includes recordings of tremor activity during transcutaneous spinal cord electrical stimulation, capturing variations in tremor patterns with different stimulation parameters. The dataset is currently published and may be made available to others upon request. The dataset provides valuable insights into how spinal cord stimulation affects tremor dynamics, offering potential for developing personalised treatments for essential tremor. DOI: 10.1002/mds.29966 - Medical products, clinical trials etc: Our pilot study explored the use of transcutaneous spinal cord stimulation (tSCS) as a potential therapeutic intervention for essential tremor (ET). We applied tSCS at different frequencies of stimulation to assess its efficacy in modulating tremor activity. this was an initial pilot study to evaluate feasibility and gather preliminary data. Notable Impacts: The study generated significant interest as a potential non-invasive treatment for ET, warranting further investigation. Notably, tSCS delivered at the subject's tremor frequency showed promise in alleviating postural tremor in patients with ET. - Awards & recognition: - Our work was accepted as a late-breaking abstract at the Movement Disorder Society (MDS) Congress 2024 in Philadelphia. This highlights the significance and timeliness of our findings within the field. - Anna Latorre was personally invited to discuss the research on the Movement Disorder Society Podcast, providing an opportunity to share findings with a global audience and contribute to the scientific discourse in the movement disorders community.
Start Year 2023
 
Description Clinical Trial Readiness for Non-Invasive Therapeutic Neuromodulation in Ataxia Telangiectasia. Rob Dineen, Stephen Jackson, Caroline Blanchard, Alex Turner, William Whitehouse 
Organisation Nottingham University Hospitals NHS Trust
Department Children's Clinical Research Facility
Country United Kingdom 
Sector Hospitals 
PI Contribution Neuromod+ feasibility study funding award of £19,960.65 granted
Collaborator Contribution The team will conduct a feasibility study on Clinical Trial Readiness for Non-Invasive Therapeutic Neuromodulation in Ataxia Telangiectasia, using funds from the network. This interdisciplinary collaborative team includes Dineen (Lead, Medicine), expertise in ataxia telangiectasia and research interests in imaging guided neuromodulation, Jackson (Psychology), expertise in clinical trials in MNS and mechanisms of motor control, outcome measures in MNS trials, Blanchard (Early-career researcher, Medicine), neuroscientist with experience in movement analysis and A-T research, who will deliver the activity in this grant.
Impact The collaboration is multidisciplinary and combines engineering, neuroscience, clinical psychology as described above. No outcomes yet.
Start Year 2024
 
Description Clinical Trial Readiness for Non-Invasive Therapeutic Neuromodulation in Ataxia Telangiectasia. Rob Dineen, Stephen Jackson, Caroline Blanchard, Alex Turner, William Whitehouse 
Organisation University of Nottingham
Department School of Computer Science
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £19,960.65 granted
Collaborator Contribution The team will conduct a feasibility study on Clinical Trial Readiness for Non-Invasive Therapeutic Neuromodulation in Ataxia Telangiectasia, using funds from the network. This interdisciplinary collaborative team includes Dineen (Lead, Medicine), expertise in ataxia telangiectasia and research interests in imaging guided neuromodulation, Jackson (Psychology), expertise in clinical trials in MNS and mechanisms of motor control, outcome measures in MNS trials, Blanchard (Early-career researcher, Medicine), neuroscientist with experience in movement analysis and A-T research, who will deliver the activity in this grant.
Impact The collaboration is multidisciplinary and combines engineering, neuroscience, clinical psychology as described above. No outcomes yet.
Start Year 2024
 
Description Clinical Trial Readiness for Non-Invasive Therapeutic Neuromodulation in Ataxia Telangiectasia. Rob Dineen, Stephen Jackson, Caroline Blanchard, Alex Turner, William Whitehouse 
Organisation University of Nottingham
Department School of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £19,960.65 granted
Collaborator Contribution The team will conduct a feasibility study on Clinical Trial Readiness for Non-Invasive Therapeutic Neuromodulation in Ataxia Telangiectasia, using funds from the network. This interdisciplinary collaborative team includes Dineen (Lead, Medicine), expertise in ataxia telangiectasia and research interests in imaging guided neuromodulation, Jackson (Psychology), expertise in clinical trials in MNS and mechanisms of motor control, outcome measures in MNS trials, Blanchard (Early-career researcher, Medicine), neuroscientist with experience in movement analysis and A-T research, who will deliver the activity in this grant.
Impact The collaboration is multidisciplinary and combines engineering, neuroscience, clinical psychology as described above. No outcomes yet.
Start Year 2024
 
Description Clinical Trial Readiness for Non-Invasive Therapeutic Neuromodulation in Ataxia Telangiectasia. Rob Dineen, Stephen Jackson, Caroline Blanchard, Alex Turner, William Whitehouse 
Organisation University of Nottingham
Department School of Psychology Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £19,960.65 granted
Collaborator Contribution The team will conduct a feasibility study on Clinical Trial Readiness for Non-Invasive Therapeutic Neuromodulation in Ataxia Telangiectasia, using funds from the network. This interdisciplinary collaborative team includes Dineen (Lead, Medicine), expertise in ataxia telangiectasia and research interests in imaging guided neuromodulation, Jackson (Psychology), expertise in clinical trials in MNS and mechanisms of motor control, outcome measures in MNS trials, Blanchard (Early-career researcher, Medicine), neuroscientist with experience in movement analysis and A-T research, who will deliver the activity in this grant.
Impact The collaboration is multidisciplinary and combines engineering, neuroscience, clinical psychology as described above. No outcomes yet.
Start Year 2024
 
Description Closed-loop focused neuromodulation: Testing different strategies in healthy human participants. Marcus Kaiser, Mohammad Zia Katshu, James Choi, Sophie Morse 
Organisation Imperial College London
Department Department of Bioengineering
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £79,517.32 granted.
Collaborator Contribution The team will conduct a feasibility study on Closed-loop focused neuromodulation, using funds from the network. Marcus Kaiser (Professor of Neuroinformatics) will lead this project including supervision of experiments and data analysis. Mohammad Zia Katshu is Clinical Associate Professor, an expert in assessment of mental health symptoms and cognitive functions, and runs Early Intervention Psychosis service and TMS services. Zia will supervise measurements to assess cognitive performance. James Choi will be consulted on the experimental set-up of closed-loop FUS. Sophie Morse is an expert on ultrasound protocols and will inform on the protocols that are tested.
Impact The collaboration is multidisciplinary and combines bioengineering, neuroinformatics, ultrasound and clinical psychology as described above. No outcomes yet.
Start Year 2024
 
Description Closed-loop focused neuromodulation: Testing different strategies in healthy human participants. Marcus Kaiser, Mohammad Zia Katshu, James Choi, Sophie Morse 
Organisation University of Nottingham
Department School of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £79,517.32 granted.
Collaborator Contribution The team will conduct a feasibility study on Closed-loop focused neuromodulation, using funds from the network. Marcus Kaiser (Professor of Neuroinformatics) will lead this project including supervision of experiments and data analysis. Mohammad Zia Katshu is Clinical Associate Professor, an expert in assessment of mental health symptoms and cognitive functions, and runs Early Intervention Psychosis service and TMS services. Zia will supervise measurements to assess cognitive performance. James Choi will be consulted on the experimental set-up of closed-loop FUS. Sophie Morse is an expert on ultrasound protocols and will inform on the protocols that are tested.
Impact The collaboration is multidisciplinary and combines bioengineering, neuroinformatics, ultrasound and clinical psychology as described above. No outcomes yet.
Start Year 2024
 
Description Developing a dual neuromodulation approach for major depressive disorder: understanding action on frontal cortex using functional near infra-red spectroscopy (fNIRS). Paul Briley, Richard Morriss, Sudheer Lankappa, Peter Liddle 
Organisation Nottinghamshire Healthcare NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution Neuromod+ feasibility study funding award of £19.943.05 granted
Collaborator Contribution The team will conduct a feasibility study on developing a dual neuromodulation approach for major depressive disorder, using funds from the network. Dr Briley has developed the tACS-synchronised TMS approach and is currently running the single-session non-patient study. He will lead the project and participate in stimulation delivery, recording and analysis of measurements (including fNIRS). Dr Lankappa was Nottingham PI for the recently completed BRIGhTMIND TMS trial and is head of the Nottingham Neuromodulation Centre. He will likewise be involved in stimulation delivery and recording of measurements including fNIRS. Prof. Liddle has extensive experience in neuromodulation and neuroimaging techniques and is involved in protocol development and interpretation of findings. Prof. Morriss was CI for the BRIGhTMIND TMS trial, provides condition expertise, has extensive experience in recruitment of the target population, and is involved in protocol development and results interpretation.
Impact The collaboration is multidisciplinary and combines bioengineering with neurological and clinical expertise. Outputs: Further funding: 2024 - PhD Studentship from Nottingham NIHR Biomedical Research Centre (BRC). 2024 - NIHR BRC Capital Funding Award for neuromodulation equipment Engagement activities: Established lived experience advisory group for ongoing neuromodulation work. Ongoing intensive involvement of six people with lived experience of depression, six meetings so far Other outputs/activities related to this award: 2024-2025: Masters of Research (MRes) in Medicine - Yue Peng (ongoing). 2024-2027: PhD in Medicine - Jemima Shickle (ongoing). Research training of NIHR Academic Clinical Fellow Sue Fen Tan and Academic Foundation Programme Doctor Alex Axford Ongoing feasibility study/clinical trial in Development of a dual neuromodulation (TMS+TES) for depression. Creative products: 2025 - three videos with people with lived experience of depression, illustrating TMS, TES, and their combination, for use in projects around acceptability of neuromodulation approaches
Start Year 2023
 
Description Development of Patient and Public Involvement for Neurotechnologies. Antonio Valentin, Tamar Makin, Tiago Da Silva Costa, Kat Richardson, Amparo Guemes 
Organisation King's College London
Department Institute of Psychiatry, Psychology & Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £19,091.91 granted
Collaborator Contribution The team will conduct a feasibility study on Development of Patient and Public Involvement for Neurotechnologies, using funds from the network.Antonio Valentin is a clinician specialised in epilepsy at King's College London, King's College Hospital (KCH) and Great Ormond Street Hospital (GOSH). He will provide clinical neurological perspective and his experience in previous PPI. Tiago Costa is specialised in depression at Newcastle University and the Cumbria, Northumberland, Tyne and Wear NHS Trust. He will provide clinical perspectives from psychiatry and his experience in previous PPI. Tamar Makin, a professor of Cognitive Neuroscience at Cambridge, will provide a research perspective. Amparo Guemes at the University of Cambridge, with a background in engineering, will bring expertise in the development and application of neurotechnology. Kat Richardson, manager of the CloseNIT network, brings experience in project management and organising PPI events.
Impact The collaboration is multidisciplinary and combines engineering with clinical neurology, clinical psychiatry, cognitive neuroscience, and PPI experience. Outputs: Publications: Foundational guidelines for enhancing neurotechnology research and development through end-user involvement. https://doi.org/10.1088/1741-2552/adac0d Collaboration/translational partnership: This project enabled a collaboration between a clinically active NHS clinicians, one of them based in the North East of England and the other one in London, and engineers / neuroscientists based in Cambridge. It therefore represents a truly multidisciplinary effort across both discipline and geographical barriers. No formal agreements have been created for these other collaborations, that started in September 2023, and were instrumental in establishing a framework of PPI in neurotechnology and providing valuable feedback on the manuscript. - Neil Roberts (Science and Engineering Health Technologies Alliance, SEHTA) - Rebecca Woodcock (NIHR MindTech MedTech Co-operative) - Vanessa Pinfold (The McPin Foundation) - Annabel Walsh (The McPin Foundation) - Chris Gibbs (Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust) Further funding: 9-month matched funding by CloseNIT Network to Amparo Guemes/George Malliaras, 'closeNIT - Development of Patient and Public Involvement for Neurotechnologies' Engagement activities: Network+ Meeting (Sept 2023, Newcastle): Hybrid session on Patient and Public Involvement (PPI) in Neurotechnologies and a PPI lived experience panel. UK Symposium on Neuromodulation and Neurotechnology (2024): Session on PPI in Neurotechnology PPI Sessions on Specific Topics with Lived Experience (2024) Awards & recognition: 1. Our publication and initiative were highlighted in the Story News section of the Department of Engineering's newsletter: https://www.eng.cam.ac.uk/news/neurotechnology-developments-shaped-researchers-and-end-users. 2. Invitation to UKRI Innovate UK Business Connect Neurotechnology Conference (2024 - https://iuk.ktn-uk.org/events/neurotechnology-conference): Pitch presentation on end-user involvement in neurotechnologies. Approx. 50 people from diverse backgrounds (start-ups, researchers, clinicians, people with lived experiences, charities, funders.) from the UK. 3. Invited speaker to the Royal Academy of the Engineering Awardee Excellence Community Conference 2024
Start Year 2023
 
Description Development of Patient and Public Involvement for Neurotechnologies. Antonio Valentin, Tamar Makin, Tiago Da Silva Costa, Kat Richardson, Amparo Guemes 
Organisation Newcastle University
Department Faculty of Medical Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £19,091.91 granted
Collaborator Contribution The team will conduct a feasibility study on Development of Patient and Public Involvement for Neurotechnologies, using funds from the network.Antonio Valentin is a clinician specialised in epilepsy at King's College London, King's College Hospital (KCH) and Great Ormond Street Hospital (GOSH). He will provide clinical neurological perspective and his experience in previous PPI. Tiago Costa is specialised in depression at Newcastle University and the Cumbria, Northumberland, Tyne and Wear NHS Trust. He will provide clinical perspectives from psychiatry and his experience in previous PPI. Tamar Makin, a professor of Cognitive Neuroscience at Cambridge, will provide a research perspective. Amparo Guemes at the University of Cambridge, with a background in engineering, will bring expertise in the development and application of neurotechnology. Kat Richardson, manager of the CloseNIT network, brings experience in project management and organising PPI events.
Impact The collaboration is multidisciplinary and combines engineering with clinical neurology, clinical psychiatry, cognitive neuroscience, and PPI experience. Outputs: Publications: Foundational guidelines for enhancing neurotechnology research and development through end-user involvement. https://doi.org/10.1088/1741-2552/adac0d Collaboration/translational partnership: This project enabled a collaboration between a clinically active NHS clinicians, one of them based in the North East of England and the other one in London, and engineers / neuroscientists based in Cambridge. It therefore represents a truly multidisciplinary effort across both discipline and geographical barriers. No formal agreements have been created for these other collaborations, that started in September 2023, and were instrumental in establishing a framework of PPI in neurotechnology and providing valuable feedback on the manuscript. - Neil Roberts (Science and Engineering Health Technologies Alliance, SEHTA) - Rebecca Woodcock (NIHR MindTech MedTech Co-operative) - Vanessa Pinfold (The McPin Foundation) - Annabel Walsh (The McPin Foundation) - Chris Gibbs (Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust) Further funding: 9-month matched funding by CloseNIT Network to Amparo Guemes/George Malliaras, 'closeNIT - Development of Patient and Public Involvement for Neurotechnologies' Engagement activities: Network+ Meeting (Sept 2023, Newcastle): Hybrid session on Patient and Public Involvement (PPI) in Neurotechnologies and a PPI lived experience panel. UK Symposium on Neuromodulation and Neurotechnology (2024): Session on PPI in Neurotechnology PPI Sessions on Specific Topics with Lived Experience (2024) Awards & recognition: 1. Our publication and initiative were highlighted in the Story News section of the Department of Engineering's newsletter: https://www.eng.cam.ac.uk/news/neurotechnology-developments-shaped-researchers-and-end-users. 2. Invitation to UKRI Innovate UK Business Connect Neurotechnology Conference (2024 - https://iuk.ktn-uk.org/events/neurotechnology-conference): Pitch presentation on end-user involvement in neurotechnologies. Approx. 50 people from diverse backgrounds (start-ups, researchers, clinicians, people with lived experiences, charities, funders.) from the UK. 3. Invited speaker to the Royal Academy of the Engineering Awardee Excellence Community Conference 2024
Start Year 2023
 
Description Development of Patient and Public Involvement for Neurotechnologies. Antonio Valentin, Tamar Makin, Tiago Da Silva Costa, Kat Richardson, Amparo Guemes 
Organisation University College London
Department Institute of Cognitive Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £19,091.91 granted
Collaborator Contribution The team will conduct a feasibility study on Development of Patient and Public Involvement for Neurotechnologies, using funds from the network.Antonio Valentin is a clinician specialised in epilepsy at King's College London, King's College Hospital (KCH) and Great Ormond Street Hospital (GOSH). He will provide clinical neurological perspective and his experience in previous PPI. Tiago Costa is specialised in depression at Newcastle University and the Cumbria, Northumberland, Tyne and Wear NHS Trust. He will provide clinical perspectives from psychiatry and his experience in previous PPI. Tamar Makin, a professor of Cognitive Neuroscience at Cambridge, will provide a research perspective. Amparo Guemes at the University of Cambridge, with a background in engineering, will bring expertise in the development and application of neurotechnology. Kat Richardson, manager of the CloseNIT network, brings experience in project management and organising PPI events.
Impact The collaboration is multidisciplinary and combines engineering with clinical neurology, clinical psychiatry, cognitive neuroscience, and PPI experience. Outputs: Publications: Foundational guidelines for enhancing neurotechnology research and development through end-user involvement. https://doi.org/10.1088/1741-2552/adac0d Collaboration/translational partnership: This project enabled a collaboration between a clinically active NHS clinicians, one of them based in the North East of England and the other one in London, and engineers / neuroscientists based in Cambridge. It therefore represents a truly multidisciplinary effort across both discipline and geographical barriers. No formal agreements have been created for these other collaborations, that started in September 2023, and were instrumental in establishing a framework of PPI in neurotechnology and providing valuable feedback on the manuscript. - Neil Roberts (Science and Engineering Health Technologies Alliance, SEHTA) - Rebecca Woodcock (NIHR MindTech MedTech Co-operative) - Vanessa Pinfold (The McPin Foundation) - Annabel Walsh (The McPin Foundation) - Chris Gibbs (Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust) Further funding: 9-month matched funding by CloseNIT Network to Amparo Guemes/George Malliaras, 'closeNIT - Development of Patient and Public Involvement for Neurotechnologies' Engagement activities: Network+ Meeting (Sept 2023, Newcastle): Hybrid session on Patient and Public Involvement (PPI) in Neurotechnologies and a PPI lived experience panel. UK Symposium on Neuromodulation and Neurotechnology (2024): Session on PPI in Neurotechnology PPI Sessions on Specific Topics with Lived Experience (2024) Awards & recognition: 1. Our publication and initiative were highlighted in the Story News section of the Department of Engineering's newsletter: https://www.eng.cam.ac.uk/news/neurotechnology-developments-shaped-researchers-and-end-users. 2. Invitation to UKRI Innovate UK Business Connect Neurotechnology Conference (2024 - https://iuk.ktn-uk.org/events/neurotechnology-conference): Pitch presentation on end-user involvement in neurotechnologies. Approx. 50 people from diverse backgrounds (start-ups, researchers, clinicians, people with lived experiences, charities, funders.) from the UK. 3. Invited speaker to the Royal Academy of the Engineering Awardee Excellence Community Conference 2024
Start Year 2023
 
Description Development of Patient and Public Involvement for Neurotechnologies. Antonio Valentin, Tamar Makin, Tiago Da Silva Costa, Kat Richardson, Amparo Guemes 
Organisation University of Cambridge
Department Department of Engineering
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £19,091.91 granted
Collaborator Contribution The team will conduct a feasibility study on Development of Patient and Public Involvement for Neurotechnologies, using funds from the network.Antonio Valentin is a clinician specialised in epilepsy at King's College London, King's College Hospital (KCH) and Great Ormond Street Hospital (GOSH). He will provide clinical neurological perspective and his experience in previous PPI. Tiago Costa is specialised in depression at Newcastle University and the Cumbria, Northumberland, Tyne and Wear NHS Trust. He will provide clinical perspectives from psychiatry and his experience in previous PPI. Tamar Makin, a professor of Cognitive Neuroscience at Cambridge, will provide a research perspective. Amparo Guemes at the University of Cambridge, with a background in engineering, will bring expertise in the development and application of neurotechnology. Kat Richardson, manager of the CloseNIT network, brings experience in project management and organising PPI events.
Impact The collaboration is multidisciplinary and combines engineering with clinical neurology, clinical psychiatry, cognitive neuroscience, and PPI experience. Outputs: Publications: Foundational guidelines for enhancing neurotechnology research and development through end-user involvement. https://doi.org/10.1088/1741-2552/adac0d Collaboration/translational partnership: This project enabled a collaboration between a clinically active NHS clinicians, one of them based in the North East of England and the other one in London, and engineers / neuroscientists based in Cambridge. It therefore represents a truly multidisciplinary effort across both discipline and geographical barriers. No formal agreements have been created for these other collaborations, that started in September 2023, and were instrumental in establishing a framework of PPI in neurotechnology and providing valuable feedback on the manuscript. - Neil Roberts (Science and Engineering Health Technologies Alliance, SEHTA) - Rebecca Woodcock (NIHR MindTech MedTech Co-operative) - Vanessa Pinfold (The McPin Foundation) - Annabel Walsh (The McPin Foundation) - Chris Gibbs (Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust) Further funding: 9-month matched funding by CloseNIT Network to Amparo Guemes/George Malliaras, 'closeNIT - Development of Patient and Public Involvement for Neurotechnologies' Engagement activities: Network+ Meeting (Sept 2023, Newcastle): Hybrid session on Patient and Public Involvement (PPI) in Neurotechnologies and a PPI lived experience panel. UK Symposium on Neuromodulation and Neurotechnology (2024): Session on PPI in Neurotechnology PPI Sessions on Specific Topics with Lived Experience (2024) Awards & recognition: 1. Our publication and initiative were highlighted in the Story News section of the Department of Engineering's newsletter: https://www.eng.cam.ac.uk/news/neurotechnology-developments-shaped-researchers-and-end-users. 2. Invitation to UKRI Innovate UK Business Connect Neurotechnology Conference (2024 - https://iuk.ktn-uk.org/events/neurotechnology-conference): Pitch presentation on end-user involvement in neurotechnologies. Approx. 50 people from diverse backgrounds (start-ups, researchers, clinicians, people with lived experiences, charities, funders.) from the UK. 3. Invited speaker to the Royal Academy of the Engineering Awardee Excellence Community Conference 2024
Start Year 2023
 
Description Fostering Acceptance and Inclusivity of Non-Invasive Neurotechnology in African Ethnic Minority Communities. Mahnaz Arvaneh, Daniel Blackburn, Lise Sproson, Ismail Yussuf 
Organisation Israac Somali Community & Cultural Association
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £19,993.00 granted
Collaborator Contribution The team will conduct a feasibility study on Fostering Acceptance and Inclusivity of Non-Invasive Neurotechnology in African Ethnic Minority Communities, using funds from the network. Mahnaz Arvaneh, expert in non-invasive BCI and brain stimulation, will lead the project. Daniel Blackburn, Consultant Neurologist, will provide insights on neuroscience and neurological diseases that might be treated by non-invasive neuroethology. Lise Sproson is the Patient and Public Involvement Lead, expert in designing and delivering meaningful user-centred PPI workshops. Sarah Goodwin is PPI Officer, helping in designing and delivering PPI workshops, Ismail Yussuf, Israac and Operations Manager, will facilitate accessing to Somalian community and organising the user-centred workshops. Sahra Abdi and Muse Jama, D4D Community Research Associates and Israac Advice and Support Workers, will identify potential participants, coordinate and set up of the workshops, assist with translation and administration of the reimbursement vouchers. Jake Toth and Mian Kou, University of Sheffield researchers specializing in non-invasive brain stimulation and imaging, will lead the literature review, design workshops, create questionnaires, analyze data, 3D print alternative solutions, and deliver the final report.
Impact The collaboration is multidisciplinary and combines engineering, clinical neurology, imaging, PPI. Outputs: Collaboration with Parkinson's UK Further funding: £406K grant from ARIA, Project title "Addressing inequity and adoption barriers of neurotechnology among marginalised groups" Invited talk on Inclusive Neurotechnology in KTN event on Emerging Technologies for Health and Safety (30/1/25)
Start Year 2024
 
Description Fostering Acceptance and Inclusivity of Non-Invasive Neurotechnology in African Ethnic Minority Communities. Mahnaz Arvaneh, Daniel Blackburn, Lise Sproson, Ismail Yussuf 
Organisation National Institute for Health and Care Research
Department NIHR Devices for Dignity Healthcare Technology Co-Operative
Country United Kingdom 
Sector Public 
PI Contribution Neuromod+ feasibility study funding award of £19,993.00 granted
Collaborator Contribution The team will conduct a feasibility study on Fostering Acceptance and Inclusivity of Non-Invasive Neurotechnology in African Ethnic Minority Communities, using funds from the network. Mahnaz Arvaneh, expert in non-invasive BCI and brain stimulation, will lead the project. Daniel Blackburn, Consultant Neurologist, will provide insights on neuroscience and neurological diseases that might be treated by non-invasive neuroethology. Lise Sproson is the Patient and Public Involvement Lead, expert in designing and delivering meaningful user-centred PPI workshops. Sarah Goodwin is PPI Officer, helping in designing and delivering PPI workshops, Ismail Yussuf, Israac and Operations Manager, will facilitate accessing to Somalian community and organising the user-centred workshops. Sahra Abdi and Muse Jama, D4D Community Research Associates and Israac Advice and Support Workers, will identify potential participants, coordinate and set up of the workshops, assist with translation and administration of the reimbursement vouchers. Jake Toth and Mian Kou, University of Sheffield researchers specializing in non-invasive brain stimulation and imaging, will lead the literature review, design workshops, create questionnaires, analyze data, 3D print alternative solutions, and deliver the final report.
Impact The collaboration is multidisciplinary and combines engineering, clinical neurology, imaging, PPI. Outputs: Collaboration with Parkinson's UK Further funding: £406K grant from ARIA, Project title "Addressing inequity and adoption barriers of neurotechnology among marginalised groups" Invited talk on Inclusive Neurotechnology in KTN event on Emerging Technologies for Health and Safety (30/1/25)
Start Year 2024
 
Description Fostering Acceptance and Inclusivity of Non-Invasive Neurotechnology in African Ethnic Minority Communities. Mahnaz Arvaneh, Daniel Blackburn, Lise Sproson, Ismail Yussuf 
Organisation University of Sheffield
Department Automatic Control and Systems Engineering
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £19,993.00 granted
Collaborator Contribution The team will conduct a feasibility study on Fostering Acceptance and Inclusivity of Non-Invasive Neurotechnology in African Ethnic Minority Communities, using funds from the network. Mahnaz Arvaneh, expert in non-invasive BCI and brain stimulation, will lead the project. Daniel Blackburn, Consultant Neurologist, will provide insights on neuroscience and neurological diseases that might be treated by non-invasive neuroethology. Lise Sproson is the Patient and Public Involvement Lead, expert in designing and delivering meaningful user-centred PPI workshops. Sarah Goodwin is PPI Officer, helping in designing and delivering PPI workshops, Ismail Yussuf, Israac and Operations Manager, will facilitate accessing to Somalian community and organising the user-centred workshops. Sahra Abdi and Muse Jama, D4D Community Research Associates and Israac Advice and Support Workers, will identify potential participants, coordinate and set up of the workshops, assist with translation and administration of the reimbursement vouchers. Jake Toth and Mian Kou, University of Sheffield researchers specializing in non-invasive brain stimulation and imaging, will lead the literature review, design workshops, create questionnaires, analyze data, 3D print alternative solutions, and deliver the final report.
Impact The collaboration is multidisciplinary and combines engineering, clinical neurology, imaging, PPI. Outputs: Collaboration with Parkinson's UK Further funding: £406K grant from ARIA, Project title "Addressing inequity and adoption barriers of neurotechnology among marginalised groups" Invited talk on Inclusive Neurotechnology in KTN event on Emerging Technologies for Health and Safety (30/1/25)
Start Year 2024
 
Description Fostering Acceptance and Inclusivity of Non-Invasive Neurotechnology in African Ethnic Minority Communities. Mahnaz Arvaneh, Daniel Blackburn, Lise Sproson, Ismail Yussuf 
Organisation University of Sheffield
Department Department of Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £19,993.00 granted
Collaborator Contribution The team will conduct a feasibility study on Fostering Acceptance and Inclusivity of Non-Invasive Neurotechnology in African Ethnic Minority Communities, using funds from the network. Mahnaz Arvaneh, expert in non-invasive BCI and brain stimulation, will lead the project. Daniel Blackburn, Consultant Neurologist, will provide insights on neuroscience and neurological diseases that might be treated by non-invasive neuroethology. Lise Sproson is the Patient and Public Involvement Lead, expert in designing and delivering meaningful user-centred PPI workshops. Sarah Goodwin is PPI Officer, helping in designing and delivering PPI workshops, Ismail Yussuf, Israac and Operations Manager, will facilitate accessing to Somalian community and organising the user-centred workshops. Sahra Abdi and Muse Jama, D4D Community Research Associates and Israac Advice and Support Workers, will identify potential participants, coordinate and set up of the workshops, assist with translation and administration of the reimbursement vouchers. Jake Toth and Mian Kou, University of Sheffield researchers specializing in non-invasive brain stimulation and imaging, will lead the literature review, design workshops, create questionnaires, analyze data, 3D print alternative solutions, and deliver the final report.
Impact The collaboration is multidisciplinary and combines engineering, clinical neurology, imaging, PPI. Outputs: Collaboration with Parkinson's UK Further funding: £406K grant from ARIA, Project title "Addressing inequity and adoption barriers of neurotechnology among marginalised groups" Invited talk on Inclusive Neurotechnology in KTN event on Emerging Technologies for Health and Safety (30/1/25)
Start Year 2024
 
Description Imperial-RIKEN collaboration on the dynamic engram 
Organisation RIKEN
Country Japan 
Sector Public 
PI Contribution This is a new collaboration between Imperial College and the RIKEN Center for Brain Science in Tokyo, triggered in part by results of the EPSRC/Wellcome project "Statistical Physics of Cognition" (SPC) as well as the NEURMOD+ project, and which provides one avenue for follow-on work from that grant. At Imperial we are collecting data based on a two-photon mesoscale that has been constructed as part of the SPC grant.
Collaborator Contribution The RIKEN team (headed by Tom McHugh) are providing data and insight into how to apply the techniques developed in SPC to questions relating to the consolidation of memory from the hippocampus into the neocortex.
Impact A new collaboration, so not yet.
Start Year 2024
 
Description Justin Andrushko: Neuromod+ ECR funding for placement to Oxford University 
Organisation University of Oxford
Department Nuffield Department of Clinical Neurosciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ ECR funding award for £1040 to enable placement
Collaborator Contribution Research placement for Justin Andrushko, Assistant Professor & Vice-Chancellor Fellow, Department of Sport, Exercise and Rehabilitation, Northumbria University, to visit Charlotte Stagg, Nuffield Department of Clinical Neurosciences, Oxford University. Objectives: To gain practical and theoretical skills around transcranial alternating current stimulation (tACS) and develop collaborations (see placement section)
Impact Outcomes described in placements section
Start Year 2024
 
Description Leveraging Multisite Transcranial Ultrasound Stimulation of the Dorsal Anterior Cingulate Cortex for Endogenous Pain Modulation 
Organisation University of Plymouth
Department Brain Research & Imaging Centre (BRIC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £63,870 granted
Collaborator Contribution The team will conduct a feasibility study on Leveraging Multisite Transcranial Ultrasound Stimulation of the Dorsal Anterior Cingulate Cortex for Endogenous Pain Modulation, using funds from the network. Dr Fouragnan heads the NIBS unit at BRIC and is a pioneer in TUS, with studies showing robust and consistent changes in neural activity and behaviour. She will lead the TUS and MRI integration. Dr Hughes is an expert in neurophysiological and neuromodulation methods for endogenous pain states. He will provide leadership on probing and measuring pain states. Dr Clarke, completed a PhD on the neurophysiology of pain. She will collect the TUS-dACC data alongside Bethan Barrett who will ensure the double-binding. Participants will provide feedback throughout the study. A workshop will involve clinicians and patients to refine the potential of TUS for chronic pain and to ensure that therapeutic TUS evolves in line with real-clinical needs.
Impact The collaboration is multidisciplinary and combines TUS, MRI and neurophysiology. No outcomes yet.
Start Year 2024
 
Description Neurochemical basis of Focused ultrasound stimulation (FUS) on Memory. JeYoung Jung, Marcus Kaiser, Matthew Lambon Ralph, Elena Stylianopoulou 
Organisation Cardiff University
Department School of Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £75,709.24 granted
Collaborator Contribution The team will conduct a feasibility study on Neurochemical basis of Focused ultrasound stimulation (FUS) on Memory, using funds from the network. JeYoung Jung is an early career, assistant professor and has combined online/offline non-invasive brain stimulation (TMS and tDCS) with neuroimaging. She is leading an Academy of Medical Sciences-funded study on the neurochemical mechanisms of memory in dementia. Marcus Kaiser is Professor of Neuroinformatics, Chair of Neuroinformatics UK, and Fellow of the Royal Society of Biology. He is a world renowned scholar in human connectomes and contributes his expertise in measuring brain connectivity and predicting FUS effects. Matt Lambon Ralph is the director of MRC Cognition and Brain Science Unit and a world-leading scholar in semantic memory and dementia. He provides his expertise to evaluate memory function using cognitive experimental paradigms and neuroimaging. Elena Stylianopoulou has MSc in cognitive neuroscience and clinical psychology and will focus on the proposed project during her PhD.
Impact The collaboration is multidisciplinary and involves neuroimaging, neuroinformatics, cognitive neuroscience and clinical psychology. Outcomes: Research Datasets, Databases & Models: in the middle of data collection. We have collected 20 healthy participants' data of FUS combined multimodal imaging for project 1 (2 visits, total = 40 sessions). Publications: Ventricle stimulation as a potential gold-standard control stimulation site for transcranial focused ultrasound stimulation. DOI: 10.1016/j.brs.2024.12.003 Further funding: MRC programme grant (co-I. PI: Marcus Kaiser), Closed-loop non-invasive stimulation for improving brain and mental health. £2.2M Awards & recognition: 1. Research poster prize, Brainbox Initiative Conference 2024 for Non-Invasive Brain Stimulation, London (Enhancing semantic memory with transcranial focused ultrasound stimulation of the anterior temporal lobe). 2. Invited talk at Imperial College London (May 2024), title: Exploring the Neural Basis of Transcranial Focused Ultrasound Stimulation for Enhancing Semantic Memory. 3. Conference talk at UK Symposium on Neuromodulation and Neurotechnology (2024), title: Enhancing semantic memory with transcranial focused ultrasound stimulation of the anterior temporal lobe. 4. Invited talk at the Department of Psychology, Korea University, South Korea (2024), title: Transcranial focused ultrasound stimulation enhances semantic memory. 5. Conference talk at British Neuropsychology Society Autumn conference (2024), title: Transcranial focused ultrasound stimulation on semantic memory. 6. Invited talk at CBU, University of Cambridge (2025), title: Transcranial focused ultrasound stimulation enhances semantic memory by modulating neurochemistry, and neural dynamics in the semantic network. 7. Invited talk at the School of Psychology, University of Sheffield (2024), title: Transcranial focused ultrasound stimulation enhances semantic memory by modulating neurochemistry, and neural dynamics in the semantic network.
Start Year 2023
 
Description Neurochemical basis of Focused ultrasound stimulation (FUS) on Memory. JeYoung Jung, Marcus Kaiser, Matthew Lambon Ralph, Elena Stylianopoulou 
Organisation University of Nottingham
Department School of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £75,709.24 granted
Collaborator Contribution The team will conduct a feasibility study on Neurochemical basis of Focused ultrasound stimulation (FUS) on Memory, using funds from the network. JeYoung Jung is an early career, assistant professor and has combined online/offline non-invasive brain stimulation (TMS and tDCS) with neuroimaging. She is leading an Academy of Medical Sciences-funded study on the neurochemical mechanisms of memory in dementia. Marcus Kaiser is Professor of Neuroinformatics, Chair of Neuroinformatics UK, and Fellow of the Royal Society of Biology. He is a world renowned scholar in human connectomes and contributes his expertise in measuring brain connectivity and predicting FUS effects. Matt Lambon Ralph is the director of MRC Cognition and Brain Science Unit and a world-leading scholar in semantic memory and dementia. He provides his expertise to evaluate memory function using cognitive experimental paradigms and neuroimaging. Elena Stylianopoulou has MSc in cognitive neuroscience and clinical psychology and will focus on the proposed project during her PhD.
Impact The collaboration is multidisciplinary and involves neuroimaging, neuroinformatics, cognitive neuroscience and clinical psychology. Outcomes: Research Datasets, Databases & Models: in the middle of data collection. We have collected 20 healthy participants' data of FUS combined multimodal imaging for project 1 (2 visits, total = 40 sessions). Publications: Ventricle stimulation as a potential gold-standard control stimulation site for transcranial focused ultrasound stimulation. DOI: 10.1016/j.brs.2024.12.003 Further funding: MRC programme grant (co-I. PI: Marcus Kaiser), Closed-loop non-invasive stimulation for improving brain and mental health. £2.2M Awards & recognition: 1. Research poster prize, Brainbox Initiative Conference 2024 for Non-Invasive Brain Stimulation, London (Enhancing semantic memory with transcranial focused ultrasound stimulation of the anterior temporal lobe). 2. Invited talk at Imperial College London (May 2024), title: Exploring the Neural Basis of Transcranial Focused Ultrasound Stimulation for Enhancing Semantic Memory. 3. Conference talk at UK Symposium on Neuromodulation and Neurotechnology (2024), title: Enhancing semantic memory with transcranial focused ultrasound stimulation of the anterior temporal lobe. 4. Invited talk at the Department of Psychology, Korea University, South Korea (2024), title: Transcranial focused ultrasound stimulation enhances semantic memory. 5. Conference talk at British Neuropsychology Society Autumn conference (2024), title: Transcranial focused ultrasound stimulation on semantic memory. 6. Invited talk at CBU, University of Cambridge (2025), title: Transcranial focused ultrasound stimulation enhances semantic memory by modulating neurochemistry, and neural dynamics in the semantic network. 7. Invited talk at the School of Psychology, University of Sheffield (2024), title: Transcranial focused ultrasound stimulation enhances semantic memory by modulating neurochemistry, and neural dynamics in the semantic network.
Start Year 2023
 
Description Neurochemical basis of Focused ultrasound stimulation (FUS) on Memory. JeYoung Jung, Marcus Kaiser, Matthew Lambon Ralph, Elena Stylianopoulou 
Organisation University of Nottingham
Department School of Psychology Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £75,709.24 granted
Collaborator Contribution The team will conduct a feasibility study on Neurochemical basis of Focused ultrasound stimulation (FUS) on Memory, using funds from the network. JeYoung Jung is an early career, assistant professor and has combined online/offline non-invasive brain stimulation (TMS and tDCS) with neuroimaging. She is leading an Academy of Medical Sciences-funded study on the neurochemical mechanisms of memory in dementia. Marcus Kaiser is Professor of Neuroinformatics, Chair of Neuroinformatics UK, and Fellow of the Royal Society of Biology. He is a world renowned scholar in human connectomes and contributes his expertise in measuring brain connectivity and predicting FUS effects. Matt Lambon Ralph is the director of MRC Cognition and Brain Science Unit and a world-leading scholar in semantic memory and dementia. He provides his expertise to evaluate memory function using cognitive experimental paradigms and neuroimaging. Elena Stylianopoulou has MSc in cognitive neuroscience and clinical psychology and will focus on the proposed project during her PhD.
Impact The collaboration is multidisciplinary and involves neuroimaging, neuroinformatics, cognitive neuroscience and clinical psychology. Outcomes: Research Datasets, Databases & Models: in the middle of data collection. We have collected 20 healthy participants' data of FUS combined multimodal imaging for project 1 (2 visits, total = 40 sessions). Publications: Ventricle stimulation as a potential gold-standard control stimulation site for transcranial focused ultrasound stimulation. DOI: 10.1016/j.brs.2024.12.003 Further funding: MRC programme grant (co-I. PI: Marcus Kaiser), Closed-loop non-invasive stimulation for improving brain and mental health. £2.2M Awards & recognition: 1. Research poster prize, Brainbox Initiative Conference 2024 for Non-Invasive Brain Stimulation, London (Enhancing semantic memory with transcranial focused ultrasound stimulation of the anterior temporal lobe). 2. Invited talk at Imperial College London (May 2024), title: Exploring the Neural Basis of Transcranial Focused Ultrasound Stimulation for Enhancing Semantic Memory. 3. Conference talk at UK Symposium on Neuromodulation and Neurotechnology (2024), title: Enhancing semantic memory with transcranial focused ultrasound stimulation of the anterior temporal lobe. 4. Invited talk at the Department of Psychology, Korea University, South Korea (2024), title: Transcranial focused ultrasound stimulation enhances semantic memory. 5. Conference talk at British Neuropsychology Society Autumn conference (2024), title: Transcranial focused ultrasound stimulation on semantic memory. 6. Invited talk at CBU, University of Cambridge (2025), title: Transcranial focused ultrasound stimulation enhances semantic memory by modulating neurochemistry, and neural dynamics in the semantic network. 7. Invited talk at the School of Psychology, University of Sheffield (2024), title: Transcranial focused ultrasound stimulation enhances semantic memory by modulating neurochemistry, and neural dynamics in the semantic network.
Start Year 2023
 
Description Optimising transcranial electrical stimulation for motor neurone disease. Alekhya Mandali, James Alix 
Organisation University of Sheffield
Department Department of Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £19,875.00 granted.
Collaborator Contribution The team will conduct a feasibility study on Optimising transcranial electrical stimulation for motor neurone disease, using funds from the network. Alekhya Mandali has expertise in various non-invasive stimulation protocols and electrophysiological/behavioural analyses in healthy and clinical groups. Dr Mandali has managed complex multi-session projects combining electrophysiology and tES. Dr Mandali will focus on design, data analysis, and dissemination of findings. James Alix is a Senior Clinical Lecturer in Neurophysiology and honorary Consultant Clinical Neurophysiologist with a particular interest in motor neurone disease. Dr Alix has expertise in various aspects of MND, from pathophysiology to clinical application-based projects, and he has established threshold tracking-TMS as a standard investigation for MND in Sheffield.
Impact The collaboration is multidisciplinary and combines engineering, electrophysiology, neurophysiology, clinical psychiatry. The project was presented at the 6th International Brain Stimulation Conference, Kobe (2025). No other outcomes yet.
Start Year 2024
 
Description Optimising transcranial electrical stimulation for motor neurone disease. Alekhya Mandali, James Alix 
Organisation University of Sheffield
Department Department of Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £19,875.00 granted.
Collaborator Contribution The team will conduct a feasibility study on Optimising transcranial electrical stimulation for motor neurone disease, using funds from the network. Alekhya Mandali has expertise in various non-invasive stimulation protocols and electrophysiological/behavioural analyses in healthy and clinical groups. Dr Mandali has managed complex multi-session projects combining electrophysiology and tES. Dr Mandali will focus on design, data analysis, and dissemination of findings. James Alix is a Senior Clinical Lecturer in Neurophysiology and honorary Consultant Clinical Neurophysiologist with a particular interest in motor neurone disease. Dr Alix has expertise in various aspects of MND, from pathophysiology to clinical application-based projects, and he has established threshold tracking-TMS as a standard investigation for MND in Sheffield.
Impact The collaboration is multidisciplinary and combines engineering, electrophysiology, neurophysiology, clinical psychiatry. The project was presented at the 6th International Brain Stimulation Conference, Kobe (2025). No other outcomes yet.
Start Year 2024
 
Description PPI in neurotechnology - new collaborations fostered through Neuromod+ funded project "Development of Patient and Public Involvement for Neurotechnologies" 
Organisation McPin Foundation
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Funding of original project "Development of Patient and Public Involvement for Neurotechnologies". Funded team has researched and developed guidelines.
Collaborator Contribution Translational partnership: This project enabled a collaboration between a clinically active NHS clinicians, one of them based in the North East of England and the other one in London, and engineers / neuroscientists based in Cambridge. It therefore represents a truly multidisciplinary effort across both discipline and geographical barriers. These collaborations were instrumental in establishing a framework of PPI in neurotechnology and providing valuable feedback on the manuscript. - Neil Roberts (Science and Engineering Health Technologies Alliance, SEHTA) - Rebecca Woodcock (NIHR MindTech MedTech Co-operative) - Vanessa Pinfold (The McPin Foundation) - Annabel Walsh (The McPin Foundation) - Chris Gibbs (Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust)
Impact See outputs for original project "Development of Patient and Public Involvement for Neurotechnologies".
Start Year 2023
 
Description PPI in neurotechnology - new collaborations fostered through Neuromod+ funded project "Development of Patient and Public Involvement for Neurotechnologies" 
Organisation NIHR MindTech MedTech Co-operative
Country United Kingdom 
Sector Public 
PI Contribution Funding of original project "Development of Patient and Public Involvement for Neurotechnologies". Funded team has researched and developed guidelines.
Collaborator Contribution Translational partnership: This project enabled a collaboration between a clinically active NHS clinicians, one of them based in the North East of England and the other one in London, and engineers / neuroscientists based in Cambridge. It therefore represents a truly multidisciplinary effort across both discipline and geographical barriers. These collaborations were instrumental in establishing a framework of PPI in neurotechnology and providing valuable feedback on the manuscript. - Neil Roberts (Science and Engineering Health Technologies Alliance, SEHTA) - Rebecca Woodcock (NIHR MindTech MedTech Co-operative) - Vanessa Pinfold (The McPin Foundation) - Annabel Walsh (The McPin Foundation) - Chris Gibbs (Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust)
Impact See outputs for original project "Development of Patient and Public Involvement for Neurotechnologies".
Start Year 2023
 
Description Personalised dual-site dual-device neuromodulation for anxiety 
Organisation University of Nottingham
Department School of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £19,275.10 granted
Collaborator Contribution The team will conduct a feasibility study on Personalised dual-site dual-device neuromodulation for anxiety, using funds from the network. Prof Morriss was CI for the BRIGhTMIND trial of TMS for treatment-resistant depression, with expertise in mood disorders, clinical trials, and translation. He will co-supervise and advise on the protocol and future research directions. Dr Briley is an academic psychiatrist, with expertise in examining antidepressant effects and brain activity changes with the approaches used herein. He recently developed a dual-device tACS-TMS depression protocol. He will co-supervise and advise on the protocol and analyses. Dr Webster is a research fellow with experience in PPI, study delivery and analysis. She developed the dual-site dual-device tACS-TMS anxiety protocol to be used in this project, and will support delivery and analysis. Jemima Shickle will commence her PhD on neuromodulation for mental health disorders in October 2024. She has experience in programming and neuroimaging and will support study delivery and analysis.
Impact The collaboration is multidisciplinary and combines engineering, tACS, TMS, PPI, and clinical psychiatry. No outcomes yet.
Start Year 2024
 
Description Reliability and optimization of somatosensory afferent inhibition (SAI) as a clinical biomarker in healthy ageing. Katherine Dyke, Domenica Veniero, Luigi Tamè, Nicholas Holmes 
Organisation University of Birmingham
Department School of Sport, Exercise and Rehabilitation Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £64,539.54 granted
Collaborator Contribution The team will combine non-invasive brain stimulation and EEG brain imaging to improve understanding of how the healthy brain ages. They will also create evidence-based guidelines for individualising stimulation parameters, allowing research groups to optimise measures for healthy and clinical groups. This new information will provide a unique and valuable reference for the assessment of clinical disorders of touch and movement. KD, NH, LT will lead data collection at their respective sites, supervise one RA testing 40 participants, and host one meeting. In addition to these shared roles: KD will project manage, develop training for RAs, and liaise with collaborators and journals (Brain Stimulation, Cortex) to deliver wider impact. NH will focus on systematic review, meta-analysis and software development; liaise with Bergmann and Hassan; organise the TMS Workshop; and champion open science principles. LT will liaise with manufacturers, and with the Kent's Parkinson's Centre for Integrated Therapy to support healthy ageing participants recruitment. DV will use her extensive experience in TMS-EEG and multicentric studies (EEGManylabs, T4Te initiatives) to coordinate and optimise set-up and analysis across sites.
Impact The collaboration is multidisciplinary and combines engineering, TMS, peripheral nerve stimulation, EEG imaging, meta-analysis, PPI. No outcomes yet.
Start Year 2024
 
Description Reliability and optimization of somatosensory afferent inhibition (SAI) as a clinical biomarker in healthy ageing. Katherine Dyke, Domenica Veniero, Luigi Tamè, Nicholas Holmes 
Organisation University of Nottingham
Department School of Psychology Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £64,539.54 granted
Collaborator Contribution The team will combine non-invasive brain stimulation and EEG brain imaging to improve understanding of how the healthy brain ages. They will also create evidence-based guidelines for individualising stimulation parameters, allowing research groups to optimise measures for healthy and clinical groups. This new information will provide a unique and valuable reference for the assessment of clinical disorders of touch and movement. KD, NH, LT will lead data collection at their respective sites, supervise one RA testing 40 participants, and host one meeting. In addition to these shared roles: KD will project manage, develop training for RAs, and liaise with collaborators and journals (Brain Stimulation, Cortex) to deliver wider impact. NH will focus on systematic review, meta-analysis and software development; liaise with Bergmann and Hassan; organise the TMS Workshop; and champion open science principles. LT will liaise with manufacturers, and with the Kent's Parkinson's Centre for Integrated Therapy to support healthy ageing participants recruitment. DV will use her extensive experience in TMS-EEG and multicentric studies (EEGManylabs, T4Te initiatives) to coordinate and optimise set-up and analysis across sites.
Impact The collaboration is multidisciplinary and combines engineering, TMS, peripheral nerve stimulation, EEG imaging, meta-analysis, PPI. No outcomes yet.
Start Year 2024
 
Description Remediating depressive cognition using a novel brain stimulation device. Jacinta O'Shea, Tim Denison, Verena Sarrazin, Emile Radyte, Fatima Khokar, Majid Memarian, Michael Browning 
Organisation Oxford Health NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Neuromod+ feasibility study funding award of £67,784.82 granted
Collaborator Contribution O'Shea is a neuroscientist with expertise in developing cognitively designed brain stimulation therapies for psychiatric and neurological brain disorders. She will lead data acquisition, analysis and interpretation. Denison leads the team that developed the programmable TMS device. He and Mermarian will provide engineering support. Sarrazin has expertise in recruiting/testing volunteers with depression. She will co-lead and supervise junior team members in data acquisition, analysis and interpretation. Browning is a Consultant Psychiatrist who leads the Oxford Health Mood Clinic. He will provide ad hoc psychiatric consultation, cover and support. Radyte and Khokhar will collect the data and be trained in analysis and interpretation. We will consult our BRC-funded Depression Therapeutics Lived Experience panel at the project's start, middle and end, and recruit one consultant to embed within our team to advise us on EDI optimization.
Impact The collaboration is multidisciplinary and combines engineering, clinical psychiatry, neurology, PPI. No outcomes yet.
Start Year 2024
 
Description Remediating depressive cognition using a novel brain stimulation device. Jacinta O'Shea, Tim Denison, Verena Sarrazin, Emile Radyte, Fatima Khokar, Majid Memarian, Michael Browning 
Organisation The Magstim Company Limited
Country United Kingdom 
Sector Private 
PI Contribution Neuromod+ feasibility study funding award of £67,784.82 granted
Collaborator Contribution O'Shea is a neuroscientist with expertise in developing cognitively designed brain stimulation therapies for psychiatric and neurological brain disorders. She will lead data acquisition, analysis and interpretation. Denison leads the team that developed the programmable TMS device. He and Mermarian will provide engineering support. Sarrazin has expertise in recruiting/testing volunteers with depression. She will co-lead and supervise junior team members in data acquisition, analysis and interpretation. Browning is a Consultant Psychiatrist who leads the Oxford Health Mood Clinic. He will provide ad hoc psychiatric consultation, cover and support. Radyte and Khokhar will collect the data and be trained in analysis and interpretation. We will consult our BRC-funded Depression Therapeutics Lived Experience panel at the project's start, middle and end, and recruit one consultant to embed within our team to advise us on EDI optimization.
Impact The collaboration is multidisciplinary and combines engineering, clinical psychiatry, neurology, PPI. No outcomes yet.
Start Year 2024
 
Description Remediating depressive cognition using a novel brain stimulation device. Jacinta O'Shea, Tim Denison, Verena Sarrazin, Emile Radyte, Fatima Khokar, Majid Memarian, Michael Browning 
Organisation University of Oxford
Department Department of Engineering Science
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £67,784.82 granted
Collaborator Contribution O'Shea is a neuroscientist with expertise in developing cognitively designed brain stimulation therapies for psychiatric and neurological brain disorders. She will lead data acquisition, analysis and interpretation. Denison leads the team that developed the programmable TMS device. He and Mermarian will provide engineering support. Sarrazin has expertise in recruiting/testing volunteers with depression. She will co-lead and supervise junior team members in data acquisition, analysis and interpretation. Browning is a Consultant Psychiatrist who leads the Oxford Health Mood Clinic. He will provide ad hoc psychiatric consultation, cover and support. Radyte and Khokhar will collect the data and be trained in analysis and interpretation. We will consult our BRC-funded Depression Therapeutics Lived Experience panel at the project's start, middle and end, and recruit one consultant to embed within our team to advise us on EDI optimization.
Impact The collaboration is multidisciplinary and combines engineering, clinical psychiatry, neurology, PPI. No outcomes yet.
Start Year 2024
 
Description Remediating depressive cognition using a novel brain stimulation device. Jacinta O'Shea, Tim Denison, Verena Sarrazin, Emile Radyte, Fatima Khokar, Majid Memarian, Michael Browning 
Organisation University of Oxford
Department Department of Experimental Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £67,784.82 granted
Collaborator Contribution O'Shea is a neuroscientist with expertise in developing cognitively designed brain stimulation therapies for psychiatric and neurological brain disorders. She will lead data acquisition, analysis and interpretation. Denison leads the team that developed the programmable TMS device. He and Mermarian will provide engineering support. Sarrazin has expertise in recruiting/testing volunteers with depression. She will co-lead and supervise junior team members in data acquisition, analysis and interpretation. Browning is a Consultant Psychiatrist who leads the Oxford Health Mood Clinic. He will provide ad hoc psychiatric consultation, cover and support. Radyte and Khokhar will collect the data and be trained in analysis and interpretation. We will consult our BRC-funded Depression Therapeutics Lived Experience panel at the project's start, middle and end, and recruit one consultant to embed within our team to advise us on EDI optimization.
Impact The collaboration is multidisciplinary and combines engineering, clinical psychiatry, neurology, PPI. No outcomes yet.
Start Year 2024
 
Description Remediating depressive cognition using a novel brain stimulation device. Jacinta O'Shea, Tim Denison, Verena Sarrazin, Emile Radyte, Fatima Khokar, Majid Memarian, Michael Browning 
Organisation University of Oxford
Department Department of Psychiatry
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £67,784.82 granted
Collaborator Contribution O'Shea is a neuroscientist with expertise in developing cognitively designed brain stimulation therapies for psychiatric and neurological brain disorders. She will lead data acquisition, analysis and interpretation. Denison leads the team that developed the programmable TMS device. He and Mermarian will provide engineering support. Sarrazin has expertise in recruiting/testing volunteers with depression. She will co-lead and supervise junior team members in data acquisition, analysis and interpretation. Browning is a Consultant Psychiatrist who leads the Oxford Health Mood Clinic. He will provide ad hoc psychiatric consultation, cover and support. Radyte and Khokhar will collect the data and be trained in analysis and interpretation. We will consult our BRC-funded Depression Therapeutics Lived Experience panel at the project's start, middle and end, and recruit one consultant to embed within our team to advise us on EDI optimization.
Impact The collaboration is multidisciplinary and combines engineering, clinical psychiatry, neurology, PPI. No outcomes yet.
Start Year 2024
 
Description Runhao Lu: Neuromod+ ECR funding for placement to Oxford University 
Organisation Medical Research Council (MRC)
Department MRC Cognition and Brain Sciences Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ award for £1000 to enable placement
Collaborator Contribution Awardee: Runhao Lu, MRC Cognition and Brain Sciences Unit, University of Cambridge. Host PI: Matthew Rushworth, Department of Experimental Psychology, Oxford University Exploring Transcranial Focused Ultrasound Stimulation (FUS) in Cognitive Neuroscience Objectives: To gain both theoretical and practical skills in transcranial focused ultrasound stimulation (FUS) within the domain of cognitive neuroscience. To build research collaborations with FUS researchers in Oxford.
Impact See placements section
Start Year 2024
 
Description Runhao Lu: Neuromod+ ECR funding for placement to Oxford University 
Organisation University of Oxford
Department Department of Experimental Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ award for £1000 to enable placement
Collaborator Contribution Awardee: Runhao Lu, MRC Cognition and Brain Sciences Unit, University of Cambridge. Host PI: Matthew Rushworth, Department of Experimental Psychology, Oxford University Exploring Transcranial Focused Ultrasound Stimulation (FUS) in Cognitive Neuroscience Objectives: To gain both theoretical and practical skills in transcranial focused ultrasound stimulation (FUS) within the domain of cognitive neuroscience. To build research collaborations with FUS researchers in Oxford.
Impact See placements section
Start Year 2024
 
Description Sharp-wave ripple triggered neuromodulation for memory enhancement. Simon Schultz, Hayriye Cagnan, Ashwini Oswal, David Dupret 
Organisation Imperial College London
Department Department of Bioengineering
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £78,890.00 granted
Collaborator Contribution The team will conduct a feasibility study on Sharp-wave ripple triggered neuromodulation for memory enhancement, using funds from the network. Simon Schultz will lead the overall project, coordinating the individual research actions and leading efforts to leverage results into a larger-scale externally funded research programme. His group will develop the optogenetic mouse model of SWR-triggered neuromodulation. Hayriye Cagnan will provide expertise on human MEG imaging. Ashwini Oswal will provide clinical input on the treatment of memory disorders in human patients, as well as collaborating on the MEG imaging to take place in Oxford. David Dupret is an expert on the use of electrophysiological techniques to study memory in mice. He will provide specific guidance on the measurement of sharp-wave ripples in the optogenetic model. We will consult with potential users (patients, lay-people, clinicians, carers) to gather feedback on what type of noninvasive neuromodulation system subjects will be most comfortable with, and how studies using the equipment should be designed.
Impact The collaboration is multidisciplinary and combines bioengineering, electrophysiology, clinical expertise. No outcomes yet.
Start Year 2024
 
Description Sharp-wave ripple triggered neuromodulation for memory enhancement. Simon Schultz, Hayriye Cagnan, Ashwini Oswal, David Dupret 
Organisation Medical Research Council (MRC)
Department MRC Brain Network Dynamics Unit at the University of Oxford (BNDU)
Country United Kingdom 
Sector Public 
PI Contribution Neuromod+ feasibility study funding award of £78,890.00 granted
Collaborator Contribution The team will conduct a feasibility study on Sharp-wave ripple triggered neuromodulation for memory enhancement, using funds from the network. Simon Schultz will lead the overall project, coordinating the individual research actions and leading efforts to leverage results into a larger-scale externally funded research programme. His group will develop the optogenetic mouse model of SWR-triggered neuromodulation. Hayriye Cagnan will provide expertise on human MEG imaging. Ashwini Oswal will provide clinical input on the treatment of memory disorders in human patients, as well as collaborating on the MEG imaging to take place in Oxford. David Dupret is an expert on the use of electrophysiological techniques to study memory in mice. He will provide specific guidance on the measurement of sharp-wave ripples in the optogenetic model. We will consult with potential users (patients, lay-people, clinicians, carers) to gather feedback on what type of noninvasive neuromodulation system subjects will be most comfortable with, and how studies using the equipment should be designed.
Impact The collaboration is multidisciplinary and combines bioengineering, electrophysiology, clinical expertise. No outcomes yet.
Start Year 2024
 
Description State-dependency of deep-brain transcranial ultrasonic neurostimulation. Miriam Klein-Flugge, Lilian Weber, Johannes Algermissen, Elsa Fouragnan, Siti Yakuub 
Organisation University of Oxford
Department Department of Experimental Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £19,216.30 granted
Collaborator Contribution The team will conduct a feasibility study on state-dependency of deep-brain transcranial ultrasonic neurostimulation, using funds from the network. Miriam Klein-Flügge brings experience of work with TUS in healthy participants. Elsa Fouragnan has recently completed and published the first human ultrasound study using offline-TUS in the UK, using theta-burst protocol. The team has extensive expertise with TUS in macaque monkeys and have trained several group members in running ultrasound experiments. Both Plymouth and Oxford offer support from colleagues in other departments. Key team members and collaborators have received training in TUS.
Impact The collaboration is multidisciplinary and combines engineering, neurobiology, cognitive neuroscience, experimental psychology. The research has been presented at the Focussed Ultrasound Conference 2024, at the UK Symposium for Neuromodulation and Neurotechnology 2024 and at the Brainbox Workshop (2024). No outcomes yet.
Start Year 2023
 
Description State-dependency of deep-brain transcranial ultrasonic neurostimulation. Miriam Klein-Flugge, Lilian Weber, Johannes Algermissen, Elsa Fouragnan, Siti Yakuub 
Organisation University of Oxford
Department Department of Psychiatry
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £19,216.30 granted
Collaborator Contribution The team will conduct a feasibility study on state-dependency of deep-brain transcranial ultrasonic neurostimulation, using funds from the network. Miriam Klein-Flügge brings experience of work with TUS in healthy participants. Elsa Fouragnan has recently completed and published the first human ultrasound study using offline-TUS in the UK, using theta-burst protocol. The team has extensive expertise with TUS in macaque monkeys and have trained several group members in running ultrasound experiments. Both Plymouth and Oxford offer support from colleagues in other departments. Key team members and collaborators have received training in TUS.
Impact The collaboration is multidisciplinary and combines engineering, neurobiology, cognitive neuroscience, experimental psychology. The research has been presented at the Focussed Ultrasound Conference 2024, at the UK Symposium for Neuromodulation and Neurotechnology 2024 and at the Brainbox Workshop (2024). No outcomes yet.
Start Year 2023
 
Description State-dependency of deep-brain transcranial ultrasonic neurostimulation. Miriam Klein-Flugge, Lilian Weber, Johannes Algermissen, Elsa Fouragnan, Siti Yakuub 
Organisation University of Plymouth
Department Psychology Plymouth
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £19,216.30 granted
Collaborator Contribution The team will conduct a feasibility study on state-dependency of deep-brain transcranial ultrasonic neurostimulation, using funds from the network. Miriam Klein-Flügge brings experience of work with TUS in healthy participants. Elsa Fouragnan has recently completed and published the first human ultrasound study using offline-TUS in the UK, using theta-burst protocol. The team has extensive expertise with TUS in macaque monkeys and have trained several group members in running ultrasound experiments. Both Plymouth and Oxford offer support from colleagues in other departments. Key team members and collaborators have received training in TUS.
Impact The collaboration is multidisciplinary and combines engineering, neurobiology, cognitive neuroscience, experimental psychology. The research has been presented at the Focussed Ultrasound Conference 2024, at the UK Symposium for Neuromodulation and Neurotechnology 2024 and at the Brainbox Workshop (2024). No outcomes yet.
Start Year 2023
 
Description Ultrasound neuromodulation with real-time 3-photon imaging. Sophie Morse, Simon Schultz, James Choi, Ann Go 
Organisation Imperial College London
Department Department of Bioengineering
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £79,990.00 granted
Collaborator Contribution The team will conduct a feasibility study on ultrasound neuromodulation with real-time 3-photon imaging, using funds from the network. This project will be led by Sophie Morse, head of the Ultrasound Therapy and Modulation Laboratory, an expert in the preclinical development of ultrasound technologies to modulate the activity of neurons and glia for the treatment of brain diseases. Her team will perform the in vivo ultrasound neuromodulation testing of the device. James Choi, who leads the Noninvasive Surgery and Biopsy Laboratory, will provide expertise in the design of ultrasound devices for brain applications. Simon Schultz and Ann Go will provide expertise in multi-photon calcium imaging during cognitive tasks and will perform the 3-photon imaging when testing the device.
Impact The collaboration is multidisciplinary and combines bioengineering, 3-photon imaging, ultrasound neuromodulation. Further funding: The team has expanded and in collaboration with Marcus Kaiser and Mohammad Zia Katshu we were awarded another NeuroMod grant in the 2024 round "Closed-loop focused ultrasound neuromodulation: testing different strategies in healthy human participants". Research tools & methods: A prototype of the device for simultaneous ultrasound and 3-photon imaging has been made but yet to be tested in vivo Awards & recognition: Sophie Morse: invited talk at Alzheimers Society Research Retreat, June 2024
Start Year 2023
 
Description Understanding the mechanisms by which low intensity focussed ultrasound is able to modulate neural activity. Tracy Farr, Marcus Kaiser, Anna Lion, Tim England 
Organisation Royal Derby Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Neuromod+ feasibility study funding award of £78,783.44 granted
Collaborator Contribution The team will conduct a feasibility study on Understanding the mechanisms by which low intensity focussed ultrasound is able to modulate neural activity, using funds from the network. Dr Farr has experience with preclinical models of neurological injury, including developing and testing novel therapeutic and rehabilitation strategies, and is interested in low intensity focussed ultrasound as a therapy for stroke. The preclinical models offer the advantage of improving our mechanistic understanding of the basis of this neuromodulation technique. Professor Kaiser is optimising cerebellar stimulation. Professor England is a consultant in stroke and will bring clinical relevance for stroke based projects as well as guidance for working with patient populations. Dr Lion will supervise the modelling and manufacture of the system.
Impact The collaboration is multidisciplinary and combines engineering, clinical neurology, focussed ultrasound. No outcomes yet.
Start Year 2024
 
Description Understanding the mechanisms by which low intensity focussed ultrasound is able to modulate neural activity. Tracy Farr, Marcus Kaiser, Anna Lion, Tim England 
Organisation University of Nottingham
Department School of Life Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £78,783.44 granted
Collaborator Contribution The team will conduct a feasibility study on Understanding the mechanisms by which low intensity focussed ultrasound is able to modulate neural activity, using funds from the network. Dr Farr has experience with preclinical models of neurological injury, including developing and testing novel therapeutic and rehabilitation strategies, and is interested in low intensity focussed ultrasound as a therapy for stroke. The preclinical models offer the advantage of improving our mechanistic understanding of the basis of this neuromodulation technique. Professor Kaiser is optimising cerebellar stimulation. Professor England is a consultant in stroke and will bring clinical relevance for stroke based projects as well as guidance for working with patient populations. Dr Lion will supervise the modelling and manufacture of the system.
Impact The collaboration is multidisciplinary and combines engineering, clinical neurology, focussed ultrasound. No outcomes yet.
Start Year 2024
 
Description Understanding the mechanisms by which low intensity focussed ultrasound is able to modulate neural activity. Tracy Farr, Marcus Kaiser, Anna Lion, Tim England 
Organisation University of Nottingham
Department School of Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £78,783.44 granted
Collaborator Contribution The team will conduct a feasibility study on Understanding the mechanisms by which low intensity focussed ultrasound is able to modulate neural activity, using funds from the network. Dr Farr has experience with preclinical models of neurological injury, including developing and testing novel therapeutic and rehabilitation strategies, and is interested in low intensity focussed ultrasound as a therapy for stroke. The preclinical models offer the advantage of improving our mechanistic understanding of the basis of this neuromodulation technique. Professor Kaiser is optimising cerebellar stimulation. Professor England is a consultant in stroke and will bring clinical relevance for stroke based projects as well as guidance for working with patient populations. Dr Lion will supervise the modelling and manufacture of the system.
Impact The collaboration is multidisciplinary and combines engineering, clinical neurology, focussed ultrasound. No outcomes yet.
Start Year 2024
 
Description Using neurophysiology and multimodal MRI to characterise cholinergic potentiation by Focused Ultrasound Neuromodulation of deep- and mid-brain structures. Charlotte Stagg, Polytimi Frangou, Saad Jbabdi, William Clarke, Elly Martin, Angelika Zarka 
Organisation University College London
Department Dementia Research Centre (DRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £79,899.85 granted
Collaborator Contribution The team will conduct a feasibility study, using neurophysiology and multimodal MRI to characterise cholinergic potentiation by Focused Ultrasound Neuromodulation of deep- and mid-brain structures. Acetylcholine (ACh) is one of the most important neurotransmitters in the human brain. Cholinergic deficits are an integral part of neurodegenerative disorders. The team will harness focused ultrasound neuromodulation to activate brain regions that are rich in ACh for the first time. They will use newly developed spectroscopic imaging tools to quantify how their intervention changes ACh in the brain. This work will set the foundation for future investigations of ACh and for developing ACh-enhancing therapeutic interventions against cholinergic deficits. Stagg is an internationally renowned expert in the use of NIBS to study human neurophysiology. Stagg and Martin pioneered the use of tUS on deep-brain structures. Stagg will oversee the project, while Martin will provide crucial guidance on the safe and successful use of tUS. Clarke is an international expert on developing ultra-high field MRS tools. Clarke and Frangou collaborate on developing tools to measure choline-containing metabolites in the brain, which will be optimised for thalamic imaging for this project. Jbabdi is a renowned expert in diffusion imaging and will guide the use of DTI in predicting tUS efficacy. Zarkali is an expert neurologist who will provide critical guidance on the cholinergic circuitry. Frangou is an expert in combining NIBS with MR Spectroscopy and will run the project.
Impact This is a multi-disciplinary project, at the forefront of methodological advances, combining tUS, MRS, diffusion imaging, MR spectroscopy, biomedical engineering, neurology. No outputs yet.
Start Year 2024
 
Description Using neurophysiology and multimodal MRI to characterise cholinergic potentiation by Focused Ultrasound Neuromodulation of deep- and mid-brain structures. Charlotte Stagg, Polytimi Frangou, Saad Jbabdi, William Clarke, Elly Martin, Angelika Zarka 
Organisation University College London
Department Department of Medical Physics and Biomedical Engineering
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £79,899.85 granted
Collaborator Contribution The team will conduct a feasibility study, using neurophysiology and multimodal MRI to characterise cholinergic potentiation by Focused Ultrasound Neuromodulation of deep- and mid-brain structures. Acetylcholine (ACh) is one of the most important neurotransmitters in the human brain. Cholinergic deficits are an integral part of neurodegenerative disorders. The team will harness focused ultrasound neuromodulation to activate brain regions that are rich in ACh for the first time. They will use newly developed spectroscopic imaging tools to quantify how their intervention changes ACh in the brain. This work will set the foundation for future investigations of ACh and for developing ACh-enhancing therapeutic interventions against cholinergic deficits. Stagg is an internationally renowned expert in the use of NIBS to study human neurophysiology. Stagg and Martin pioneered the use of tUS on deep-brain structures. Stagg will oversee the project, while Martin will provide crucial guidance on the safe and successful use of tUS. Clarke is an international expert on developing ultra-high field MRS tools. Clarke and Frangou collaborate on developing tools to measure choline-containing metabolites in the brain, which will be optimised for thalamic imaging for this project. Jbabdi is a renowned expert in diffusion imaging and will guide the use of DTI in predicting tUS efficacy. Zarkali is an expert neurologist who will provide critical guidance on the cholinergic circuitry. Frangou is an expert in combining NIBS with MR Spectroscopy and will run the project.
Impact This is a multi-disciplinary project, at the forefront of methodological advances, combining tUS, MRS, diffusion imaging, MR spectroscopy, biomedical engineering, neurology. No outputs yet.
Start Year 2024
 
Description Using neurophysiology and multimodal MRI to characterise cholinergic potentiation by Focused Ultrasound Neuromodulation of deep- and mid-brain structures. Charlotte Stagg, Polytimi Frangou, Saad Jbabdi, William Clarke, Elly Martin, Angelika Zarka 
Organisation University of Oxford
Department Nuffield Department of Clinical Neurosciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ feasibility study funding award of £79,899.85 granted
Collaborator Contribution The team will conduct a feasibility study, using neurophysiology and multimodal MRI to characterise cholinergic potentiation by Focused Ultrasound Neuromodulation of deep- and mid-brain structures. Acetylcholine (ACh) is one of the most important neurotransmitters in the human brain. Cholinergic deficits are an integral part of neurodegenerative disorders. The team will harness focused ultrasound neuromodulation to activate brain regions that are rich in ACh for the first time. They will use newly developed spectroscopic imaging tools to quantify how their intervention changes ACh in the brain. This work will set the foundation for future investigations of ACh and for developing ACh-enhancing therapeutic interventions against cholinergic deficits. Stagg is an internationally renowned expert in the use of NIBS to study human neurophysiology. Stagg and Martin pioneered the use of tUS on deep-brain structures. Stagg will oversee the project, while Martin will provide crucial guidance on the safe and successful use of tUS. Clarke is an international expert on developing ultra-high field MRS tools. Clarke and Frangou collaborate on developing tools to measure choline-containing metabolites in the brain, which will be optimised for thalamic imaging for this project. Jbabdi is a renowned expert in diffusion imaging and will guide the use of DTI in predicting tUS efficacy. Zarkali is an expert neurologist who will provide critical guidance on the cholinergic circuitry. Frangou is an expert in combining NIBS with MR Spectroscopy and will run the project.
Impact This is a multi-disciplinary project, at the forefront of methodological advances, combining tUS, MRS, diffusion imaging, MR spectroscopy, biomedical engineering, neurology. No outputs yet.
Start Year 2024
 
Description Yukiko Kikuchi: Neuromod+ ECR funding for collaborative workshop with Newcastle and Leeds universities 
Organisation Newcastle University
Department Biosciences Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ ECR funding award for £2000 to enable hosting of collaborative workshop
Collaborator Contribution The aim of activity is to develop research ideas between neuroscience and bioengineering ECRs researchers at Newcastle and Leeds University to facilitate developing an innovative wireless implantable device for the use with a marmoset model with the following aims: 1. Develop connections and exchange knowledge between Newcastle neuroscience and Leeds bioengineering team: 2. Leeds group will visit Newcastle primate facility to observe the basic scientific approaches carried out in primate models: We will discuss the details of experimental designs with the researchers who work with primates, including how to incorporate the developed wireless EEG device into the animal behavioural experiments and the colony environment at Newcastle. 3. Organise the workshop "Marmoset and Neurotechnology" at Newcastle: to discuss on the challenges and opportunities using marmoset models for neurotechnology development. Speakers from both neuroscience and neuroengineering as well as veterinary specialists will be invited and provide for sharing knowledge and expertise to identify challenges and opportunities, barriers and potentials to use marmoset model for neurotechnology advancement.
Impact Multidisciplinary collaborations between engineering and neuroscience. outcomes as above and to follow
Start Year 2024
 
Description Yukiko Kikuchi: Neuromod+ ECR funding for collaborative workshop with Newcastle and Leeds universities 
Organisation University of Leeds
Department School of Mechanical Engineering Leeds
Country United Kingdom 
Sector Academic/University 
PI Contribution Neuromod+ ECR funding award for £2000 to enable hosting of collaborative workshop
Collaborator Contribution The aim of activity is to develop research ideas between neuroscience and bioengineering ECRs researchers at Newcastle and Leeds University to facilitate developing an innovative wireless implantable device for the use with a marmoset model with the following aims: 1. Develop connections and exchange knowledge between Newcastle neuroscience and Leeds bioengineering team: 2. Leeds group will visit Newcastle primate facility to observe the basic scientific approaches carried out in primate models: We will discuss the details of experimental designs with the researchers who work with primates, including how to incorporate the developed wireless EEG device into the animal behavioural experiments and the colony environment at Newcastle. 3. Organise the workshop "Marmoset and Neurotechnology" at Newcastle: to discuss on the challenges and opportunities using marmoset models for neurotechnology development. Speakers from both neuroscience and neuroengineering as well as veterinary specialists will be invited and provide for sharing knowledge and expertise to identify challenges and opportunities, barriers and potentials to use marmoset model for neurotechnology advancement.
Impact Multidisciplinary collaborations between engineering and neuroscience. outcomes as above and to follow
Start Year 2024
 
Description Advances in Neuromodulation workshop 2025 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This meeting was organised by Neuromod+ member Stephen Jackson with support from Neuromod+ and Parkinson's UK. The objective was to bring together clinicians, researchers, and a number of individuals with lived experience of Parkinson's Disease, to consider recent advances in non-invasive brain stimulation that are, or could be, relevant for the treatment of motor and non-motor symptoms of PD. The workshop would covered the following topics:
• Living with Parkinson's disease: PPI perspective
• Pathophysiology of PD, to include link to brain oscillations
• Overview of deep-brain stimulation: current state-of-the-art and future directions
• Overview of Non-invasive brain stimulation approaches (Focused ultrasound stimulation, Temporal interference stimulation, Peripheral nerve stimulation)
• Open-loop control: synchronising stimulation with ongoing brain activity
• Clinical translation: recent successes
• Building networks/collaboration
A key aim of this meeting is to develop new research consortia with an interest in developing non-invasive brain stimulation for PD. A second aim would be to review barriers to using non-invasive stimulation for brain health conditions such as PD (e.g., difficulties posed by having to stimulate deep brain structures using non-invasive stimulation approaches) and discuss and share current best practice. This review and discussion could lead to the preparation of a discussion/consensus article for publication where appropriate. Lastly, an important objective for this workshop is to promote discussion and debate that would likely lead to the generation of one or more research grant applications.
Year(s) Of Engagement Activity 2025
 
Description International Meeting on Brain Stimulation 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The meeting was organised by Neuromod+ member Nir Grossman with support from Neuromod+.
The aim of the International Meeting on TI Brain Stimulation Meeting was to enhance the field's impact on brain sciences and diseases by facilitating the exchange of knowledge and synergetic research among the leading groups worldwide. In the meeting, we aimed to highlight achievements and elucidate the challenges, limitations, and opportunities to help guide better practices and the development of improvement strategies.
A select number of academic and industrial groups were invited, who have been at the forefront of driving the development and/or deployment of TI brain stimulation. This gathering was designed to maximise the synergetic and interactive nature of the meeting. The meeting was highly successful and sparked excellent discussions.
Year(s) Of Engagement Activity 2024
 
Description Interview on the Movement Disorder Society podcast re publication: Frequency-Selective Suppression of Essential Tremor via Transcutaneous Spinal Cord Stimulation 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Interview on the Movement Disorder Society podcast about our research paper, to share findings with a global audience and foster dialogue within the movement disorder community. The podcast reached an international audience and received positive feedback, demonstrating its impact in spreading our findings.
Year(s) Of Engagement Activity 2024
 
Description Neuromod+ Co-creation event - March 2023 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Co-creation workshop bringing together network members to discuss and define themes and challenges for Neuromod+, and brainstorm new developments in minimally invasive neuromodulation, ahead of the first network funding call. Objectives and Outcomes were to build from the Launch in November 2022, enable co -creation of ideas on non invasive techniques for brain modulation for possible funding from the Neuromod+ network, to facilitate networking and continue to build the network and discuss the network's Ethics Charter. The event enabled further definition of network priorities, discussion and development of emerging research challenges/themes, refinement of the ethics charter and suggestions for further action, plus networking and building collaborations. Almost half (47%) of attendees went on to apply for funding in the first or second Neuromod+ funding call.
Year(s) Of Engagement Activity 2023
URL https://neuromodplus.org/events/
 
Description Neuromod+ at Imperial Lates: Weird Science 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact We hosted an interactive exhibit at the public science festival event "Imperial Lates: Weird Science" which attracted over 500 visitors. The stand aimed to give visitors the opportunity to learn out about our network's research, and the great potential of neuromodulation to treat a wide range of conditions, through:
• A VR demo where visitors can interact with virtual patients to learn about 3 different neuromodulation techniques
• hands-on experience of two types of neuromodulation device which visitors can see working/try out
• A full-sized wooden arcade machine containing a game representing stimulation in the brain
• Discussion with our researchers
• The opportunity to contribute opinions about neuromodulation to an opinion wall
The exhibit was well received and we estimated at least 50 visitors, who enjoyed asking questions and discussing our research and trying out our activities. Visitors were asked whether they would consider using nonivasive neuromodulation and overwhelmingly answered yes. Visitors reported enjoying the activities and discussions.
Year(s) Of Engagement Activity 2025
URL https://neuromodplus.org/event2/neuromod-at-imperial-lates/
 
Description Neuromod+ launch event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Online network launch to introduce the aims objectives and outcomes of the Network, introduce the NeuroMod+ team and our planned activities, engage participants in the shaping of the network, and to start the process of building a community and the co-creation of broad research ideas. Over 80 attendees joined the event. The event started with a networking session followed by introductions to network aims, activities and team. Three discussion sessions followed, with recorded video insight talks from network members discussing unmet clinical need and opportunities, to stimulate discussion. the event enabled members to meet and network with one another and resulted in definition of network priorities.
Year(s) Of Engagement Activity 2022
URL https://neuromodplus.org/events/
 
Description Neuromod+ website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Launch of Neuromod+ website, including information on network aims and priorities, team and funding opportunities, calendar of events, news items, online registration form and online searchable members directory. Also included are videos giving patient, clinician, academic and charity perspectives on how Neuromod+ could help address the challenge of treatment for brain disorders and the facility for members to create special interest groups. Presence of the website has increased network registrations, registrations to network events and funding calls and allowed members to network/find colleagues working in areas of interest.
Year(s) Of Engagement Activity 2022
URL https://neuromodplus.org
 
Description Nottingham Festival of Science and Curiosity 2024 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact We hosted an interactive exhibit at the Nottingham Festival of Science and Curiosity - a public and family focussed festival. The stand gave visitors the opportunity to learn out about our network's research, and how neuromodulation can be used to treat a wide range of conditions, through: • A VR demo where visitors could interact with virtual patients to learn about 3 different neuromodulation techniques • hands-on experience of two types of neuromodulation device which visitors could see working/try out • An interactive game representing stimulation in the brain • Discussion with our researchers • The opportunity to contribute opinions about neuromodulation. Kids and parents had a great time exploring the VR neuromodulation experience and discovering Neuromod+. Many parents also tried the Zenbud, vagus nerve ultrasound stimulation and were excited to discover more about neuromodulation and its potential applications.
Year(s) Of Engagement Activity 2025
URL https://nottsfosac.co.uk/2025-festival/
 
Description PPI Network+ Meeting - Newcastle Sept 2023 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact Network+ Meeting (Sept 11-12, 2023, Newcastle): Hybrid session on Patient and Public Involvement (PPI) in Neurotechnologies and a PPI lived experience panel with 12 people (6 with lived experience), where we engaged key stakeholders (representatives of charities, medical device regulation, ethics specialists) and gathered feedback for a paper on best practices for PPI in neurotechnology.
Year(s) Of Engagement Activity 2023
URL https://www.inclusive-neurotech.co.uk/
 
Description PPI Sessions on Specific Topics with Lived Experience (2024) - part of the project "Development of Patient and Public Involvement for Neurotechnologies") 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact PPI Sessions on Specific Topics with Lived Experience: Two PPI sessions, one in-person (3 people) and one online (4 people), focused on exploring challenges faced by people with lived experience in neurotechnology, with feedback to inform future PPI engagement strategies.
Year(s) Of Engagement Activity 2024
URL https://www.inclusive-neurotech.co.uk/
 
Description PPIE in neurotechnologies presentation (Tiago Da Silva Costa, KTN Neurotechnology conference, Feb 2024) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact As part of the NeuroMod+ funded project "Development of Patient and Public Involvement for Neurotechnologies", a presentation about PPIE in neurotechnologies was made by Dr Tiago Da Silva Costa at the Innovate UK KTN Neurotechnology conference on 27th February 2024. This conference was a UK national event aimed to bring together academics and industry in the neurotech space. Outcomes are pending.
Year(s) Of Engagement Activity 2024
URL https://iuk.ktn-uk.org/events/neurotechnology-conference/
 
Description Seminar: JeYoung Jung - Exploring the Neural Basis of Transcranial Focused Ultrasound Stimulation for Enhancing Semantic Memory 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Hybrid seminar highlighting the research of network awardee JeYoung Jung, Assistant Professor, School of Psychology/Precision Imaging/Centre for Dementia, University of Nottingham.
Year(s) Of Engagement Activity 2024
URL https://neuromodplus.org/event2/seminar-jeyoung-jung-university-of-nottingham/
 
Description Seminar: Prof Tamar Makin - To be (biomimetic) or not to be? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Hybrid seminar hosted by Neuromod+ and Imperial College London Bioengineering Department highlighting the research of Neuromod+ member Tamar Makin. Around 50 attendees, Q&A session after seminar.
Year(s) Of Engagement Activity 2024
URL https://neuromodplus.org/event2/seminar-prof-tamar-makin/
 
Description UK Symposium on Neuromodulation & Neurotechnology featured in the Focused Ultrasound Foundation newsletter 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Our symposium (the UK Symposium on Neuromodulation and Neurotechnology 2024) was featured in the "meeting reports" blog of the Focused Ultrasound Foundation.
Year(s) Of Engagement Activity 2024
URL https://www.fusfoundation.org/posts/meeting-report-uk-symposium-on-neuromodulation-and-neurotechnolo...
 
Description UK Symposium on Neuromodulation and Neurotechnology 2024 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact UKSNN 2024 was a two-day meeting hosted jointly by Neuromod+ and CloseNIT networks. The event included a showcase of network-funded research, plenary talks from international speakers, presentations and panel discussions on PPI in neurotechnology and industry translation, and lightning talks discussing latest developments in neurotechnology and neuromodulation. The event attracted ~100 participants, including academic researchers, clinicians, industry and charity colleagues, funders and patients and PPI reps. The event stimulated excellent discussions on latest research in neurotechnology and neuromodulation and the panel and group discussions on PPI neurotechnologies contributed to recently published guidelines.
Year(s) Of Engagement Activity 2024
URL https://neuromodplus.org/event2/uk-symposium-on-neuromodulation-and-neurotechnology/
 
Description UKSNN research showcase seminar: Wako Yoshida and Sophie Morse 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Extra online session of the UK Symposium on Neuromodulation and Neurotechnology, hosted jointly by Neuromod+ and CloseNIT networks. This session showcased the research of network awardees Wako Yoshida and Sophie Morse: Wako Yoshida: Adaptive closed-loop fMRI neurofeedback for social learning, Sophie Morse: Ultrasound Modulation of Neurons and Glia
Year(s) Of Engagement Activity 2024
URL https://neuromodplus.org/event2/seminar-morse_yoshida/
 
Description https://www.inclusive-neurotech.co.uk/ 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Curated website with resources developed through project "Development of Patient and Public Involvement for Neurotechnologies" : https://www.inclusive-neurotech.co.uk/
Year(s) Of Engagement Activity 2024
URL https://www.inclusive-neurotech.co.uk/