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DNA Repair State Machines

Lead Research Organisation: University of Bristol
Department Name: Biochemistry

Abstract

The Doctoral Network RepState aims to train a new generation of innovative scientists in biochemistry and biophysics to address central questions in biology concerning the mode of action of critical DNA Repair proteins that act as state machines. RepState consists of a highly collaborative consortium consisting of 11 participants coming from academia, industry and the creative sector, representing the natural sciences as well as the social sciences. Participating laboratories in RepState are part of established research schools within renowned research organizations and universities. This environment of excellence offers a multidisciplinary PhD program to 10 young researchers, through training in the fundamental chemical and physical principles that underlie biology and human health. In addition, training will focus on method development using technology and experience provided by the academic participants as well as by the two small technology-driven companies. Training incorporates a local program, rotations within partner laboratories, exposure to the non-academic sector and annual meetings. Fellows will follow scientific workshops, courses in transferable skills and career development, and will disseminate and communicate their projects to a diverse audience in close collaboration with the creative sector. The RepState fellows will form a new generation of mature and innovative European scientists with a thorough understanding of fundamental quantitative principles underlying biology, with experience in technique development, career perspectives in multiple sectors and an understanding of the importance of the role of fundamental science for society and human health.

Publications

10 25 50
 
Description Repstate consortium 
Organisation Chalmers University of Technology
Country Sweden 
Sector Academic/University 
PI Contribution The RepState research program addresses individual DNA Repair State Machines in the MMR, NER and TC-NER pathways, their interdependencies, and their collective action ensuring efficient DNA repair, using the relevant human as well as the accessible E.coli systems as model. The RepState Training Programme consists of three major parts: Training through Research - experimental work on Individual Research Projects, Local training, and a coherent Network-wide Workshop Programme. RepState is training 13 talented young researchers who are currently pursuing their PhD Degrees at nine top EU and UK universities.
Collaborator Contribution The RepState research program addresses individual DNA Repair State Machines in the MMR, NER and TC-NER pathways, their interdependencies, and their collective action ensuring efficient DNA repair, using the relevant human as well as the accessible E.coli systems as model. The RepState Training Programme consists of three major parts: Training through Research - experimental work on Individual Research Projects, Local training, and a coherent Network-wide Workshop Programme. RepState is training 13 talented young researchers who are currently pursuing their PhD Degrees at nine top EU and UK universities.
Impact Still active
Start Year 2023
 
Description Repstate consortium 
Organisation Erasmus MC
Country Netherlands 
Sector Hospitals 
PI Contribution The RepState research program addresses individual DNA Repair State Machines in the MMR, NER and TC-NER pathways, their interdependencies, and their collective action ensuring efficient DNA repair, using the relevant human as well as the accessible E.coli systems as model. The RepState Training Programme consists of three major parts: Training through Research - experimental work on Individual Research Projects, Local training, and a coherent Network-wide Workshop Programme. RepState is training 13 talented young researchers who are currently pursuing their PhD Degrees at nine top EU and UK universities.
Collaborator Contribution The RepState research program addresses individual DNA Repair State Machines in the MMR, NER and TC-NER pathways, their interdependencies, and their collective action ensuring efficient DNA repair, using the relevant human as well as the accessible E.coli systems as model. The RepState Training Programme consists of three major parts: Training through Research - experimental work on Individual Research Projects, Local training, and a coherent Network-wide Workshop Programme. RepState is training 13 talented young researchers who are currently pursuing their PhD Degrees at nine top EU and UK universities.
Impact Still active
Start Year 2023
 
Description Repstate consortium 
Organisation Justus Liebig University Giessen
Country Germany 
Sector Academic/University 
PI Contribution The RepState research program addresses individual DNA Repair State Machines in the MMR, NER and TC-NER pathways, their interdependencies, and their collective action ensuring efficient DNA repair, using the relevant human as well as the accessible E.coli systems as model. The RepState Training Programme consists of three major parts: Training through Research - experimental work on Individual Research Projects, Local training, and a coherent Network-wide Workshop Programme. RepState is training 13 talented young researchers who are currently pursuing their PhD Degrees at nine top EU and UK universities.
Collaborator Contribution The RepState research program addresses individual DNA Repair State Machines in the MMR, NER and TC-NER pathways, their interdependencies, and their collective action ensuring efficient DNA repair, using the relevant human as well as the accessible E.coli systems as model. The RepState Training Programme consists of three major parts: Training through Research - experimental work on Individual Research Projects, Local training, and a coherent Network-wide Workshop Programme. RepState is training 13 talented young researchers who are currently pursuing their PhD Degrees at nine top EU and UK universities.
Impact Still active
Start Year 2023
 
Description Repstate consortium 
Organisation Leiden University
Country Netherlands 
Sector Academic/University 
PI Contribution The RepState research program addresses individual DNA Repair State Machines in the MMR, NER and TC-NER pathways, their interdependencies, and their collective action ensuring efficient DNA repair, using the relevant human as well as the accessible E.coli systems as model. The RepState Training Programme consists of three major parts: Training through Research - experimental work on Individual Research Projects, Local training, and a coherent Network-wide Workshop Programme. RepState is training 13 talented young researchers who are currently pursuing their PhD Degrees at nine top EU and UK universities.
Collaborator Contribution The RepState research program addresses individual DNA Repair State Machines in the MMR, NER and TC-NER pathways, their interdependencies, and their collective action ensuring efficient DNA repair, using the relevant human as well as the accessible E.coli systems as model. The RepState Training Programme consists of three major parts: Training through Research - experimental work on Individual Research Projects, Local training, and a coherent Network-wide Workshop Programme. RepState is training 13 talented young researchers who are currently pursuing their PhD Degrees at nine top EU and UK universities.
Impact Still active
Start Year 2023
 
Description Repstate consortium 
Organisation Netherlands Cancer Institute (NKI)
Country Netherlands 
Sector Academic/University 
PI Contribution The RepState research program addresses individual DNA Repair State Machines in the MMR, NER and TC-NER pathways, their interdependencies, and their collective action ensuring efficient DNA repair, using the relevant human as well as the accessible E.coli systems as model. The RepState Training Programme consists of three major parts: Training through Research - experimental work on Individual Research Projects, Local training, and a coherent Network-wide Workshop Programme. RepState is training 13 talented young researchers who are currently pursuing their PhD Degrees at nine top EU and UK universities.
Collaborator Contribution The RepState research program addresses individual DNA Repair State Machines in the MMR, NER and TC-NER pathways, their interdependencies, and their collective action ensuring efficient DNA repair, using the relevant human as well as the accessible E.coli systems as model. The RepState Training Programme consists of three major parts: Training through Research - experimental work on Individual Research Projects, Local training, and a coherent Network-wide Workshop Programme. RepState is training 13 talented young researchers who are currently pursuing their PhD Degrees at nine top EU and UK universities.
Impact Still active
Start Year 2023
 
Description Repstate consortium 
Organisation Rotterdam University of Applied Sciences
Country Netherlands 
Sector Academic/University 
PI Contribution The RepState research program addresses individual DNA Repair State Machines in the MMR, NER and TC-NER pathways, their interdependencies, and their collective action ensuring efficient DNA repair, using the relevant human as well as the accessible E.coli systems as model. The RepState Training Programme consists of three major parts: Training through Research - experimental work on Individual Research Projects, Local training, and a coherent Network-wide Workshop Programme. RepState is training 13 talented young researchers who are currently pursuing their PhD Degrees at nine top EU and UK universities.
Collaborator Contribution The RepState research program addresses individual DNA Repair State Machines in the MMR, NER and TC-NER pathways, their interdependencies, and their collective action ensuring efficient DNA repair, using the relevant human as well as the accessible E.coli systems as model. The RepState Training Programme consists of three major parts: Training through Research - experimental work on Individual Research Projects, Local training, and a coherent Network-wide Workshop Programme. RepState is training 13 talented young researchers who are currently pursuing their PhD Degrees at nine top EU and UK universities.
Impact Still active
Start Year 2023
 
Description Repstate consortium 
Organisation University of Eastern Finland
Country Finland 
Sector Academic/University 
PI Contribution The RepState research program addresses individual DNA Repair State Machines in the MMR, NER and TC-NER pathways, their interdependencies, and their collective action ensuring efficient DNA repair, using the relevant human as well as the accessible E.coli systems as model. The RepState Training Programme consists of three major parts: Training through Research - experimental work on Individual Research Projects, Local training, and a coherent Network-wide Workshop Programme. RepState is training 13 talented young researchers who are currently pursuing their PhD Degrees at nine top EU and UK universities.
Collaborator Contribution The RepState research program addresses individual DNA Repair State Machines in the MMR, NER and TC-NER pathways, their interdependencies, and their collective action ensuring efficient DNA repair, using the relevant human as well as the accessible E.coli systems as model. The RepState Training Programme consists of three major parts: Training through Research - experimental work on Individual Research Projects, Local training, and a coherent Network-wide Workshop Programme. RepState is training 13 talented young researchers who are currently pursuing their PhD Degrees at nine top EU and UK universities.
Impact Still active
Start Year 2023
 
Description Repstate consortium 
Organisation University of Leeds
Country United Kingdom 
Sector Academic/University 
PI Contribution The RepState research program addresses individual DNA Repair State Machines in the MMR, NER and TC-NER pathways, their interdependencies, and their collective action ensuring efficient DNA repair, using the relevant human as well as the accessible E.coli systems as model. The RepState Training Programme consists of three major parts: Training through Research - experimental work on Individual Research Projects, Local training, and a coherent Network-wide Workshop Programme. RepState is training 13 talented young researchers who are currently pursuing their PhD Degrees at nine top EU and UK universities.
Collaborator Contribution The RepState research program addresses individual DNA Repair State Machines in the MMR, NER and TC-NER pathways, their interdependencies, and their collective action ensuring efficient DNA repair, using the relevant human as well as the accessible E.coli systems as model. The RepState Training Programme consists of three major parts: Training through Research - experimental work on Individual Research Projects, Local training, and a coherent Network-wide Workshop Programme. RepState is training 13 talented young researchers who are currently pursuing their PhD Degrees at nine top EU and UK universities.
Impact Still active
Start Year 2023
 
Description Repstate consortium 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution The RepState research program addresses individual DNA Repair State Machines in the MMR, NER and TC-NER pathways, their interdependencies, and their collective action ensuring efficient DNA repair, using the relevant human as well as the accessible E.coli systems as model. The RepState Training Programme consists of three major parts: Training through Research - experimental work on Individual Research Projects, Local training, and a coherent Network-wide Workshop Programme. RepState is training 13 talented young researchers who are currently pursuing their PhD Degrees at nine top EU and UK universities.
Collaborator Contribution The RepState research program addresses individual DNA Repair State Machines in the MMR, NER and TC-NER pathways, their interdependencies, and their collective action ensuring efficient DNA repair, using the relevant human as well as the accessible E.coli systems as model. The RepState Training Programme consists of three major parts: Training through Research - experimental work on Individual Research Projects, Local training, and a coherent Network-wide Workshop Programme. RepState is training 13 talented young researchers who are currently pursuing their PhD Degrees at nine top EU and UK universities.
Impact Still active
Start Year 2023
 
Description Repstate consortium 
Organisation Ɖcole Normale SupĆ©rieure, Paris
Country France 
Sector Academic/University 
PI Contribution The RepState research program addresses individual DNA Repair State Machines in the MMR, NER and TC-NER pathways, their interdependencies, and their collective action ensuring efficient DNA repair, using the relevant human as well as the accessible E.coli systems as model. The RepState Training Programme consists of three major parts: Training through Research - experimental work on Individual Research Projects, Local training, and a coherent Network-wide Workshop Programme. RepState is training 13 talented young researchers who are currently pursuing their PhD Degrees at nine top EU and UK universities.
Collaborator Contribution The RepState research program addresses individual DNA Repair State Machines in the MMR, NER and TC-NER pathways, their interdependencies, and their collective action ensuring efficient DNA repair, using the relevant human as well as the accessible E.coli systems as model. The RepState Training Programme consists of three major parts: Training through Research - experimental work on Individual Research Projects, Local training, and a coherent Network-wide Workshop Programme. RepState is training 13 talented young researchers who are currently pursuing their PhD Degrees at nine top EU and UK universities.
Impact Still active
Start Year 2023
 
Description Sobott Group / Advanced Mass Spectrometry 
Organisation University of Leeds
Country United Kingdom 
Sector Academic/University 
PI Contribution My laboratory studies many proteins involved in DNA replication, repair and recombination. We supply these proteins and derivatives thereof to the Sobott laboratory for analysis by a range of mass spectrometry methods.
Collaborator Contribution The Sobott laboratory studies our proteins of interest using native mass spectrometry, Hydrogen-Deuterium Exchange coupled to mass spectrometry, crosslinking mass spectrometry, and FPOP (fast photochemical oxidation of proteins)-coupled mass spectrometry.
Impact Multidisciplinary application spanning biochemistry and biophysics. For publications see appropriate outcomes section.
Start Year 2008