Long-term memory gated encoding in working memory
Lead Research Organisation:
University of Oxford
Department Name: Clinical Neurosciences
Abstract
Humans have the remarkable ability to hold onto information - preserving it in working memory (WM) where it is ready for ongoing thought and action. Although WM is undisputedly limited to storing only small amounts of information, it is clear that we can extend this capacity by capitalizing on existing knowledge in long-term memory (LTM). But how do we connect prior knowledge in LTM to benefit WM? Imagine you need to hold a phone number in mind: you recognize that it consists of a familiar chunk such as your birth year, and it immediately becomes easier to remember. Instead of encoding each digit of the phone number in WM, one can strategically encode only the novel parts in WM and recruit LTM for the known parts. Although this is a well-established behavioral finding, theories diverge in the mechanism of connection between LTM and WM, and neural theories have never been tested empirically. I propose a novel, neurally plausible mechanism in which encoding in WM is guided by LTM to proactively decrease the cognitive load on the system: "LTM-gated encoding". Objective 1 will elucidate the bounds of this mechanism in a novel behavioral task, Objective 2 will delineate the neural interactions underlying this mechanism with magnetoencephalography (MEG), and
Objective 3 will describe the mechanism with a computational model. I will receive training in state-of-the-art neurophysiological and machine-learning methods which will prepare me for a career in computational neuroscience. The project will integrate the supervisor's technical and computational skills with my empirical domain knowledge, to build and test this new quantitative framework which contrasts with previous work in the field.
Objective 3 will describe the mechanism with a computational model. I will receive training in state-of-the-art neurophysiological and machine-learning methods which will prepare me for a career in computational neuroscience. The project will integrate the supervisor's technical and computational skills with my empirical domain knowledge, to build and test this new quantitative framework which contrasts with previous work in the field.
Publications
Attaallah B
(2023)
Role of the hippocampus in decision making under uncertainty
Bocincova A
(2022)
Neural signature of flexible coding in prefrontal cortex.
in Proceedings of the National Academy of Sciences of the United States of America
Fallon S
(2023)
Effects of cholinesterase inhibition on attention and working memory in Lewy body dementias
in Brain Communications
Grogan JP
(2022)
Motivation improves working memory by two processes: Prioritisation and retrieval thresholds.
in Cognitive psychology
Printzlau FAB
(2022)
Neural Reinstatement Tracks Spread of Attention between Object Features in Working Memory.
in Journal of cognitive neuroscience
Sun L
(2023)
Syntax through rapid synaptic changes
Tabi YA
(2022)
Vividness of visual imagery questionnaire scores and their relationship to visual short-term memory performance.
in Cortex; a journal devoted to the study of the nervous system and behavior
Udale R
(2022)
Dynamic in-flight shifts of working memory resources across saccades.
in Journal of experimental psychology. Human perception and performance
Zhao S
(2022)
Rapid vigilance and episodic memory decrements in COVID-19 survivors.
in Brain communications