Warwick Centre for Analytical Science
Lead Research Organisation:
University of Warwick
Department Name: Chemistry
Abstract
Analytical Science involves the development and application of new methods to measure the composition and structure of manufactured and natural substances of all types. The analytical sector in the UK underpins many vital industries (e.g. food, chemical, pharmaceutical, environmental, materials), is crucial to process and cost control, to product quality and competitiveness, to industrial compliance with environmental and safety legislation, and to the delivery of healthcare and justice. Crucially, progress in Analytical Science is also essential to advances in many key research areas including materials and life sciences. Modern analytical problems often require high spatial resolution in three dimensions, resulting in very large, complex data sets. Moreover, there is a need to combine information from multiple data sets of very different provenance. Recent official reviews have warned that, despite its central importance to the UK's economic and scientific competitiveness, Analytical Science in the UK suffers from low esteem and fragmentation, and lacks interdisciplinarity. The result is a shortage of analytical scientists, and an alarmingly low level of innovation compared to other countries. Research and innovation-led reinvigoration of this area is essential for the UK's economic and social well-being. The University of Warwick invests heavily in multidisciplinary research and education, and has a strong research base in Analytical Science in the Departments of Chemistry, Physics, Statistics, Engineering, Biological Sciences and the Medical School. Building on this philosophy, we have responded to the fourth Science and Innovation Call by proposing lectureships in three new interdisciplinary research areas (Chemometrics and Experimental Design, Chemical and Structural Characterisation of Materials, and Mass Spectrometry) that will be combined with diverse research in Analytical Science at Warwick to found a new Centre for Analytical Science, expected to boost the profile of Analytical Science in the UK and world-wide. Recognising the fact that scientific progress crucially depends on communication and collaboration between different disciplines and sectors, a central aim of the Centre will be to bring together people from academia and industry with the objective of providing a platform for identification, definition, and implementation of new Analytical Science research goals including the development of new instrumentation, and new methods for data acquisition and statistical inference. The process of innovation requires a dialogue between academia and the private sector. As stated in the Lambert report, the best forms of knowledge transfer involve human interaction . Therefore, the Centre will have an academic/industrial Advisory Board, and will develop, through its new Analytical Forum, a visitor and outreach programme, not only to enable the exchange of ideas, knowledge, and technology between developers and users of analytical tools in public and private sectors, but also to foster new collaborations.Applicants of the very highest quality will be attracted by offering excellent research facilities supported by PhD students and post-doctoral researchers in a well resourced multinational, multidisciplinary environment. The Centre will develop training programmes in Analytical Science, statistics and transferable skills. The integration of research and education in the Centre will offer a comprehensive approach to Analytical Science, helping to provide the UK with the skills base essential to remain internationally competitive.Warwick will nurture the new Centre by guaranteeing long-term support for the area, and by investing heavily in state-of-the-art equipment, purpose-built accommodation and infrastructure. There will be development of modules for CPD, PG and UG training which will help sustainability.
Publications
Lam YPY
(2018)
Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation?
in Chemical communications (Cambridge, England)
Gatti A
(2018)
Half-Sandwich Arene Ruthenium(II) and Osmium(II) Thiosemicarbazone Complexes: Solution Behavior and Antiproliferative Activity.
in Organometallics
Wootton CA
(2018)
Sequence-dependent attack on peptides by photoactivated platinum anticancer complexes.
in Chemical science
Gothe Y
(2018)
Synthesis and Mode of Action Studies on Iridium(I)-NHC Anticancer Drug Candidates
in European Journal of Inorganic Chemistry
Banerjee S
(2018)
New activation mechanism for half-sandwich organometallic anticancer complexes.
in Chemical science
Chellan P
(2018)
Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Coverdale J
(2018)
In Vivo Selectivity and Localization of Reactive Oxygen Species (ROS) Induction by Osmium Anticancer Complexes That Circumvent Platinum Resistance
in Journal of Medicinal Chemistry
Wu Q
(2018)
Rigid dinuclear ruthenium-arene complexes showing strong DNA interactions.
in Journal of inorganic biochemistry
Shi H
(2018)
Photoactivatable Cell-Selective Dinuclear trans-Diazidoplatinum(IV) Anticancer Prodrugs.
in Inorganic chemistry
Wootton CA
(2019)
Structural analysis of peptides modified with organo-iridium complexes, opportunities from multi-mode fragmentation.
in The Analyst
Shi H
(2019)
Dual action photosensitive platinum(II) anticancer prodrugs with photoreleasable azide ligands
in Inorganica Chimica Acta
Oliveira CG
(2019)
Palladium(ii) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors.
in Dalton transactions (Cambridge, England : 2003)
Zhang X
(2019)
Glutathione activation of an organometallic half-sandwich anticancer drug candidate by ligand attack.
in Chemical communications (Cambridge, England)
Banerjee S
(2019)
Generation of maghemite nanocrystals from iron-sulfur centres.
in Dalton transactions (Cambridge, England : 2003)
Shi H
(2019)
Diazido platinum( iv ) complexes for photoactivated anticancer chemotherapy
in Inorganic Chemistry Frontiers
Sanchez-Cano C
(2019)
Nanofocused synchrotron X-ray absorption studies of the intracellular redox state of an organometallic complex in cancer cells.
in Chemical communications (Cambridge, England)
Shi H
(2019)
Photoactive platinum(iv) complex conjugated to a cancer-cell-targeting cyclic peptide.
in Dalton transactions (Cambridge, England : 2003)
Ballesta A
(2019)
Kinetic analysis of the accumulation of a half-sandwich organo-osmium pro-drug in cancer cells.
in Metallomics : integrated biometal science
Huang H
(2019)
Targeted photoredox catalysis in cancer cells.
in Nature chemistry
Banerjee S
(2019)
Dual-action platinum(II) Schiff base complexes: Photocytotoxicity and cellular imaging
in Polyhedron
Gondim A
(2019)
Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity
in MedChemComm
Chen P
(2019)
Discovery of novel, potent, isosteviol-based antithrombotic agents.
in European journal of medicinal chemistry
Zhang WY
(2020)
Ligand-centred redox activation of inert organoiridium anticancer catalysts.
in Chemical science
Shi H
(2020)
Axial functionalisation of photoactive diazido platinum(iv) anticancer complexes.
in Inorganic chemistry frontiers
Needham RJ
(2020)
Structure-activity relationships for osmium(II) arene phenylazopyridine anticancer complexes functionalised with alkoxy and glycolic substituents.
in Journal of inorganic biochemistry
Oliveira C
(2020)
Novel tetranuclear Pd II and Pt II anticancer complexes derived from pyrene thiosemicarbazones
in Dalton Transactions
Shi H
(2020)
Biotinylated photoactive Pt( iv ) anticancer complexes
in Chemical Communications
Novohradsky V
(2020)
Induction of immunogenic cell death in cancer cells by a photoactivated platinum(IV) prodrug.
in Inorganic chemistry frontiers
Lopes L
(2020)
THE FUNDAMENTAL IMPORTANCE OF BASIC SCIENCE: EXAMPLES OF HIGH-IMPACT DISCOVERIES FROM AN INTERNATIONAL CHEMISTRY NETWORK
in QuĂmica Nova
Bolitho EM
(2020)
X-ray tomography of cryopreserved human prostate cancer cells: mitochondrial targeting by an organoiridium photosensitiser.
in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
Imberti C
(2020)
New Designs for Phototherapeutic Transition Metal Complexes.
in Angewandte Chemie (International ed. in English)
Lam YPY
(2020)
Determination of the Aggregate Binding Site of Amyloid Protofibrils Using Electron Capture Dissociation Tandem Mass Spectrometry.
in Journal of the American Society for Mass Spectrometry
Chellan P
(2020)
Enhancing the Activity of Drugs by Conjugation to Organometallic Fragments.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Needham RJ
(2021)
NMR studies of group 8 metallodrugs: 187Os-enriched organo-osmium half-sandwich anticancer complex.
in Dalton transactions (Cambridge, England : 2003)
Donnelly JM
(2021)
Cu(III)-bis-thiolato complex forms an unusual mono-thiolato Cu(III)-peroxido adduct.
in Chemical communications (Cambridge, England)
Shi H
(2021)
DNA-Intercalative Platinum Anticancer Complexes Photoactivated by Visible Light.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Kumar SA
(2021)
Dose- and time-dependent tolerability and efficacy of organo-osmium complex FY26 and its tissue pharmacokinetics in hepatocarcinoma-bearing mice.
in Metallomics : integrated biometal science
Xue X
(2021)
Photoactivated Osmium Arene Anticancer Complexes.
in Inorganic chemistry
Chellan P
(2021)
Bioactive half-sandwich Rh and Ir bipyridyl complexes containing artemisinin.
in Journal of inorganic biochemistry
Armstrong J
(2021)
Vibrational Motions Make Significant Contributions to Sequential Methyl C-H Activations in an Organometallic Complex.
in The journal of physical chemistry letters
Farley SJ
(2022)
Photoactive Platinum(II) Azopyridine Complexes.
in Photochemistry and photobiology
Shi H
(2022)
Biomedical Applications of Inorganic Photochemistry
Wang FX
(2022)
Reactions of cisplatin and oxaliplatin with penicillin G: implications for drug inactivation and biological activity.
in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
Chen F
(2022)
Effect of cysteine thiols on the catalytic and anticancer activity of Ru(II) sulfonyl-ethylenediamine complexes.
in Dalton transactions (Cambridge, England : 2003)
Sink A
(2022)
Kinetics and mechanism of sequential ring methyl C-H activation in cyclopentadienyl rhodium(III) complexes.
in Dalton transactions (Cambridge, England : 2003)
Bisceglie F
(2022)
Light Triggers the Antiproliferative Activity of Naphthalimide-Conjugated (?6-arene)ruthenium(II) Complexes.
in International journal of molecular sciences
Armstrong J
(2023)
Correction to "Vibrational Motions Make Significant Contributions to Sequential Methyl C-H Activations in an Organometallic Complex".
in The journal of physical chemistry letters
Banerjee S
(2024)
Experimental and theoretical evidence for unprecedented strong interactions of gold atoms with boron on boron/sulfur-doped carbon surfaces
in Nanoscale Advances