Imprinting methylation; early life influences and later cognition and mood.

Lead Research Organisation: University of Aberdeen
Department Name: Sch of Medicine, Medical Sci & Nutrition

Abstract

There is much evidence that early life experiences (from fetal life through childhood) can influence adult outcomes. However, the pathways and mechanisms by which earlier experiences become embedded in an individual's life-course and how they influence health and behavioral outcomes are still not clear. Epigenetics provides a key emerging platform for interdisciplinary research among the biological and social sciences to further understand the complex interactions between social phenomena and human biology and behavior. Epigenetics refers to information in the human genome other than that in the DNA sequence. Imprinting refers to a special kind of epigenetic marking of genes that occurs very early in development and is then often stable across the life course. There is increasing evidence for the importance of these epigenetic factors in brain function, cognition, mood and behavior.

We aim to investigate the effect of the early social environment on epigenetic status and its relationship to cognition and mood in later life. The proposed study exploits existing data and samples collected from two important UK longitudinal studies (Aberdeen Birth Cohorts born in 1921 and 1936). The data held includes extensive information on early social environment, later life exposures, and changes in cognition, mood, and brain volumes into old age. We believe that our hypotheses, relating to germline imprints, is particularly appropriate to such longitudinal study designs. These epigenetic marks are influenced by the early environment, they are stable over decades, they typically occur in multiple tissue types, and they are known to influence behavior.

This is a truly multidisciplinary project involving collaboration between researchers in three UK centers (University of Aberdeen, University College London, and University of Cambridge) with strong track records in the areas relevant to the call. It involves a number of social scientists and biological scientists and crucially involves the training of a post-doctoral scientist to work beyond traditional boundaries and contribute to the development of a new discipline that spans the biological and social sciences.

This work is naturally complemented by our existing programme of research on the effects of the early environment on imprinting methylation in a contemporary birth cohort where we have extensive information on maternal diet, nutritional and socioeconomic status, maternal health, birth outcome, etc. In that study we are currently measuring in newborn blood the same imprinted regions that will be studied here. That work will be used to inform the interpretation of the early life findings from the proposed study and identify contemporary early exposures that influence imprints linked to later cognition and mood.

We believe that this research provides a unique opportunity to; 1) directly measure the strength of association between early life factors, imprinting and cognition; 2) produce knowledge to underpin the development of evidence based strategies at different life stages to improve mental health and wellbeing; 3) generate specific hypotheses that can be tested in future studies in other human cohorts and brain tissue, such as that available within the MRC brain bank, 4) produce knowledge to inform the development of work in other species and model systems, and 5) contribute to the development of a new research discipline that encompasses the molecular and social sciences.

Planned Impact

Our research will contribute fundamental new knowledge with a range of potential beneficiaries in the public sector, academia, and the general public (including the participants in this study). This project has the potential to impact on; 1) the wellbeing of individuals, and society as a whole, 2) healthcare providers such as the NHS, 3) policy makers, 4) social services, 5) the commercial sector and 6) clinical and basic scientists and the wider academic community.

This research will; 1) produce knowledge to underpin the development of evidence based strategies at different life stages to improve mental health and wellbeing; 2) generate specific hypotheses that can be tested in future studies in other human cohorts and brain tissue, such as that available within the MRC brain bank, and 3) produce knowledge to inform the development of work in other species and model systems.

This work exploits existing resources to "study alternative pathways to explain the underlying factors of the diverse human responses to environmental signals." It seeks to "uncover pathways and mechanisms for modifying or reversing lasting legacies of adversity, and identifying biomarkers of exposure to adverse early experiences".

Cognition and mood are linked to early mortality and morbidity (e.g. cardiovascular disease, stroke, and respiratory disease). Cognitive decline and dementias are putting an increasing strain on healthcare budgets in our increasingly aging society. Understanding the factors early in life that influence cognition and mood, the mechanism through which they may do this, and the factors in later life that may modulate these effects, would assist in the development of effective strategies to improve social welfare and public services and health and well-being. Such improvements would be of considerable economic value and would help reduce the pressure on health services. The identification of epigenetic markers of cognition and mood in later life would also be useful in the development of better screening methods and the early identification of 'at risk' groups for targeted interventions. Elucidation of the importance of life-stage and identification of the factors which influence cognition across the life-course will help the public sector and policy makers, in the UK and internationally, develop evidence based strategies to improve lifelong cognitive health and its associated outcomes.

Elucidation of epigenetic markers related to cognition and mood has the potential to point to new areas of research and specific drug targets to improve cognition and cognitive outcomes. This could result in the development of new technologies to benefit human health, social welfare and public services in addition to providing commercial opportunities.

The research proposed here will also be relevant to academics in many of the life sciences including; human behavior and psychology, basic biology and the study of genome regulation and function. This project brings together the "biological and social sciences to further understand the complex interactions between social phenomena and human biology and behaviour." It has the potential to contribute to the development of a new research discipline that encompasses the molecular and social sciences.

Publications

10 25 50
 
Description This project used cutting-edge molecular techniques to understand the basis for the transgenerational persistence of disadvantage that is increasingly seen in the UK and globally. It has identified a possible molecular mechanism through which processes set in train in early life can influence brain health in later life. This project has identified stable epigenetic states that are influenced by the early life environment and which predict cognitive ability, mood, brain structure (MRI), and cognitive decline in later life. It has also identified epigenetic states predictive of longevity.
Exploitation Route Epigenetics provides a key emerging platform for interdisciplinary research among the biological and social sciences to further understand the complex interactions between social phenomena and human biology and behavior. We believe that this research has produced knowledge to underpin the development of evidence based social and economic strategies at different life stages to improve mental health and wellbeing across the lifecourse. It has produced new hypotheses to inform the development of molecular work in other species and model systems, and it has contributed to the development of a new research discipline that encompasses the molecular and social sciences.
Sectors Communities and Social Services/Policy,Creative Economy,Education,Healthcare,Pharmaceuticals and Medical Biotechnology

URL https://app.researchfish.com/getform/0/dissemination-to-non-academic-audiences?action=add&zone=portfolio&destination=awards/dissemination-to-non-academic-audiences/0%3Fgorderby%3Dorganisation%26ob%3Dcreated%26ds%3D0%26ne%3D%26zone%3Dportfolio%26filter%3DESRC-ES/N00048X/1%26orderby%3Dcreated%26offset%3D0&filter=ESRC-ES/N00048X/1
 
Description Results from the study have formed the basis for two publications so far and a series of further manuscripts are being prepared for submission. The initial results and the conceptual basis for the study have already informed other outcomes and developments. We have promoted understanding of this emerging area of biosocial research, and the concepts underpinning it, to the general public at a reunion event for the two study cohorts involved in this work. We have also highlighted the implications of this research for government policy in relation to the transgenerational transmission of disadvantage in a presentation to the Child and Maternal Health Division of Scottish Government. The study was the basis for advice given to the Nuffield Council on Bioethics in an invitation only event to discuss the ethical implication of epigenetics. The project led directly to the development of a large (£20m) transcontinental, multi-disciplinary project designed to reduce child undernutrition and stunting through a better understanding of the complex interaction between biological, social, environmental and behavioural factors. The results and experience of the earlier project were invaluable in designing the protocol and experimental questions in the Hub. As a result of this project I took on the role of BBSRC representative on the ESRC/BBSRC cross council initiative designed to bring together the social and biological sciences in the area of epigenetics. As part of this initiative I also contributed to the commissioning panel for the joint ESRC/BBSRC funded Biosocial Centres for Doctoral Training (CDT).
First Year Of Impact 2017
Sector Communities and Social Services/Policy,Government, Democracy and Justice
Impact Types Societal,Policy & public services

 
Description A briefing on epigenetics and the implications of our research for government policy in relation to the transgenerational transmission of disadvantage was presented to the Child and Maternal Health Division of Scottish Government and related areas (e.g. obesity).
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
 
Description Member of the UK Scientific Advisory Committee on Nutrition "Nutrition and Maternal Health" working group. The project was designed to investigate early life influences on later cognition and mood. This area of research and expertise was relevant to my appointment to this advisory committee.
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Nuffield Council on Bioethics meeting and report on the ethical implication of epigenetics
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description A Pilot Study of Epigenetic Imprinting and Breast Cancer using Next Generation Sequencing
Amount £9,399 (GBP)
Organisation Friends of ANCHOR 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2015 
End 06/2016
 
Description A Pilot Study of the Role of Carnitine Palmitoyltransferase-1 in the Progression of Breast Cancer
Amount £9,763 (GBP)
Organisation Pathological Society of Great Britain & Ireland 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2017 
End 03/2018
 
Description Breast Cancer Epigenetics
Amount £14,350 (GBP)
Funding ID RG13415 
Organisation University of Aberdeen 
Department Development Trust
Sector Charity/Non Profit
Country United Kingdom
Start 02/2016 
End 02/2017
 
Description Environmental Metabolic and Molecular Causes of Breast Cancer
Amount £9,350 (GBP)
Organisation University of Aberdeen 
Department Development Trust
Sector Charity/Non Profit
Country United Kingdom
Start 07/2017 
End 07/2018
 
Description GCRF Action against Stunting Hub
Amount £19,760,000 (GBP)
Funding ID MR/S01313X/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 02/2019 
End 02/2024
 
Description Unlocking the Joint Morphogenic Code in Mesenchymal Stem Cells from Human Synovium
Amount £327,874 (GBP)
Funding ID 21800 
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2018 
End 05/2021
 
Title Statistical analysis of large scale epigenetic sequence data. 
Description Epigenetic methodologies are developing rapidly and next generation methylation sequencing in particular is producing data on a large scale. The type of data produced by this project presents new analytical and statistical challenges. Regression analysis of large numbers of individual methylation sites increases the likelihood of significance arising by chance. In the course of this project we developed a new approach to identifying blocks of significance across contiguous methylation sites. We developed the method based on permutation analysis to identify blocks of significance adjusted for large numbers of tests. This methodology was applied to the results of the study prior to inclusion in a series of manuscripts. The general approach is applicable to other similar genomic data and data from other disciplines. The method is fully described in: Lorgen-Ritchie M, Murray AD, Staff R, Ferguson-Smith AC, Richards M, Horgan GW, ... Haggarty P. (2021). Imprinting methylation predicts hippocampal volumes and hyperintensities and the change with age in later life. Scientific reports, 11(1), pp. 943. doi: 10.1038/s41598-020-78062-2 
Type Of Material Technology assay or reagent 
Year Produced 2021 
Provided To Others? No  
Impact The method was only published two months ago so external impact on the field still largely to manifest. 
URL https://www.ncbi.nlm.nih.gov/pubmed/33441584
 
Title development of NGS bisulphite sequencing of targeted imprints 
Description NGS bisulphite sequencing of targeted imprints. The assay designs and full protocols are described in: Lorgen-Ritchie M, Murray AD, Staff R, Ferguson-Smith AC, Richards M, Horgan GW, ... Haggarty P. (2021). Imprinting methylation predicts hippocampal volumes and hyperintensities and the change with age in later life. Scientific reports, 11(1), pp. 943. 
Type Of Material Technology assay or reagent 
Year Produced 2021 
Provided To Others? Yes  
Impact The paper was only published two months ago but we expect the methods to be taken up by a number of other research teams working on epigenetics. 
URL https://www.ncbi.nlm.nih.gov/pubmed/33441584
 
Title Adding epigenetic data to Aberdeen Birth Cohort database 
Description Addition of epigenetic data to cognitive and phenotypic database. Results will be made publicly available on completion of the project and publication of all findings. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? No  
Impact Allows research team to complete statistical analysis and modelling. 
 
Title Imprinting methylation predicts hippocampal volumes and hyperintensities and the change with age in later life 
Description The paper below reporting findings from this study has been published and the study data has been made available to researchers following the policy of Sci Rep and Aberdeen Birth Cohort Steering Group. 
Type Of Material Database/Collection of data 
Year Produced 2021 
Provided To Others? Yes  
Impact To early. Only just made available two months ago. 
URL https://www.ncbi.nlm.nih.gov/pubmed/33441584
 
Title Public availability of research data 
Description The paper below reporting findings from this study has been published and the study data has been made available to researchers in accordance with the policy of PLoS One. Lorgen-Ritchie, M., A. D. Murray, A. C. Ferguson-Smith, M. Richards, G. W. Horgan, L. H. Phillips, G. Hoad, I. Gall, K. Harrison, G. McNeill, M. Ito, and P. Haggarty. 2019. 'Imprinting methylation in SNRPN and MEST1 in adult blood predicts cognitive ability', PLoS One, 14: e0211799. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
Impact The publication is the major output so far but this was only published in the last month. We expect to see impacts when researchers begin to use the data we have made available. 
URL https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0211799&type=printable
 
Description Global Challenges Research Fund International Collaboration using Epigenetics 
Organisation Digital Green
Country India 
Sector Private 
PI Contribution Member of a of a BBSRC led delegation to Nepal to develop UK-international collaboration in the area of nutrition and health. Our specific contribution was in the area of epigenetics and nutrition part of which was based on the methods and findings from this ESRC funded study. The discussions resulted in the preparation of a submission ("GCRF Action Against Stunting Hub") under the GCRF-Hub call. The hub was funded in 2019 and work has begun.
Collaborator Contribution This is a multi-disciplinary project in LMICs with each partner making a unique contribution. UK Collaborators: London Sch of Hygiene and Trop Medicine, MRC Unit, The Gambia, Liverpool School of Tropical, Int Livestock Research Institute Medicine, Royal Veterinary College, School of Oriental & African Studies, University College London, University of Brighton International collaborators: University of Indonesia, National Institute of Nutrition, India. Université Cheikh Anta DIOP, Dakar, Senegal. Digital Green.
Impact Full funding for the GCRF Action Against Stunting Hub (MR/S01313X/1).
Start Year 2019
 
Description Global Challenges Research Fund International Collaboration using Epigenetics 
Organisation International Livestock Research Institute (ILRI)
Country Kenya 
Sector Charity/Non Profit 
PI Contribution Member of a of a BBSRC led delegation to Nepal to develop UK-international collaboration in the area of nutrition and health. Our specific contribution was in the area of epigenetics and nutrition part of which was based on the methods and findings from this ESRC funded study. The discussions resulted in the preparation of a submission ("GCRF Action Against Stunting Hub") under the GCRF-Hub call. The hub was funded in 2019 and work has begun.
Collaborator Contribution This is a multi-disciplinary project in LMICs with each partner making a unique contribution. UK Collaborators: London Sch of Hygiene and Trop Medicine, MRC Unit, The Gambia, Liverpool School of Tropical, Int Livestock Research Institute Medicine, Royal Veterinary College, School of Oriental & African Studies, University College London, University of Brighton International collaborators: University of Indonesia, National Institute of Nutrition, India. Université Cheikh Anta DIOP, Dakar, Senegal. Digital Green.
Impact Full funding for the GCRF Action Against Stunting Hub (MR/S01313X/1).
Start Year 2019
 
Description Global Challenges Research Fund International Collaboration using Epigenetics 
Organisation Liverpool School of Tropical Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Member of a of a BBSRC led delegation to Nepal to develop UK-international collaboration in the area of nutrition and health. Our specific contribution was in the area of epigenetics and nutrition part of which was based on the methods and findings from this ESRC funded study. The discussions resulted in the preparation of a submission ("GCRF Action Against Stunting Hub") under the GCRF-Hub call. The hub was funded in 2019 and work has begun.
Collaborator Contribution This is a multi-disciplinary project in LMICs with each partner making a unique contribution. UK Collaborators: London Sch of Hygiene and Trop Medicine, MRC Unit, The Gambia, Liverpool School of Tropical, Int Livestock Research Institute Medicine, Royal Veterinary College, School of Oriental & African Studies, University College London, University of Brighton International collaborators: University of Indonesia, National Institute of Nutrition, India. Université Cheikh Anta DIOP, Dakar, Senegal. Digital Green.
Impact Full funding for the GCRF Action Against Stunting Hub (MR/S01313X/1).
Start Year 2019
 
Description Global Challenges Research Fund International Collaboration using Epigenetics 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Member of a of a BBSRC led delegation to Nepal to develop UK-international collaboration in the area of nutrition and health. Our specific contribution was in the area of epigenetics and nutrition part of which was based on the methods and findings from this ESRC funded study. The discussions resulted in the preparation of a submission ("GCRF Action Against Stunting Hub") under the GCRF-Hub call. The hub was funded in 2019 and work has begun.
Collaborator Contribution This is a multi-disciplinary project in LMICs with each partner making a unique contribution. UK Collaborators: London Sch of Hygiene and Trop Medicine, MRC Unit, The Gambia, Liverpool School of Tropical, Int Livestock Research Institute Medicine, Royal Veterinary College, School of Oriental & African Studies, University College London, University of Brighton International collaborators: University of Indonesia, National Institute of Nutrition, India. Université Cheikh Anta DIOP, Dakar, Senegal. Digital Green.
Impact Full funding for the GCRF Action Against Stunting Hub (MR/S01313X/1).
Start Year 2019
 
Description Global Challenges Research Fund International Collaboration using Epigenetics 
Organisation Royal Veterinary College (RVC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Member of a of a BBSRC led delegation to Nepal to develop UK-international collaboration in the area of nutrition and health. Our specific contribution was in the area of epigenetics and nutrition part of which was based on the methods and findings from this ESRC funded study. The discussions resulted in the preparation of a submission ("GCRF Action Against Stunting Hub") under the GCRF-Hub call. The hub was funded in 2019 and work has begun.
Collaborator Contribution This is a multi-disciplinary project in LMICs with each partner making a unique contribution. UK Collaborators: London Sch of Hygiene and Trop Medicine, MRC Unit, The Gambia, Liverpool School of Tropical, Int Livestock Research Institute Medicine, Royal Veterinary College, School of Oriental & African Studies, University College London, University of Brighton International collaborators: University of Indonesia, National Institute of Nutrition, India. Université Cheikh Anta DIOP, Dakar, Senegal. Digital Green.
Impact Full funding for the GCRF Action Against Stunting Hub (MR/S01313X/1).
Start Year 2019
 
Description Global Challenges Research Fund International Collaboration using Epigenetics 
Organisation School of Oriental and African Studies (University of London)
Country United Kingdom 
Sector Academic/University 
PI Contribution Member of a of a BBSRC led delegation to Nepal to develop UK-international collaboration in the area of nutrition and health. Our specific contribution was in the area of epigenetics and nutrition part of which was based on the methods and findings from this ESRC funded study. The discussions resulted in the preparation of a submission ("GCRF Action Against Stunting Hub") under the GCRF-Hub call. The hub was funded in 2019 and work has begun.
Collaborator Contribution This is a multi-disciplinary project in LMICs with each partner making a unique contribution. UK Collaborators: London Sch of Hygiene and Trop Medicine, MRC Unit, The Gambia, Liverpool School of Tropical, Int Livestock Research Institute Medicine, Royal Veterinary College, School of Oriental & African Studies, University College London, University of Brighton International collaborators: University of Indonesia, National Institute of Nutrition, India. Université Cheikh Anta DIOP, Dakar, Senegal. Digital Green.
Impact Full funding for the GCRF Action Against Stunting Hub (MR/S01313X/1).
Start Year 2019
 
Description Global Challenges Research Fund International Collaboration using Epigenetics 
Organisation Universitas Indonesia
Country Indonesia 
Sector Academic/University 
PI Contribution Member of a of a BBSRC led delegation to Nepal to develop UK-international collaboration in the area of nutrition and health. Our specific contribution was in the area of epigenetics and nutrition part of which was based on the methods and findings from this ESRC funded study. The discussions resulted in the preparation of a submission ("GCRF Action Against Stunting Hub") under the GCRF-Hub call. The hub was funded in 2019 and work has begun.
Collaborator Contribution This is a multi-disciplinary project in LMICs with each partner making a unique contribution. UK Collaborators: London Sch of Hygiene and Trop Medicine, MRC Unit, The Gambia, Liverpool School of Tropical, Int Livestock Research Institute Medicine, Royal Veterinary College, School of Oriental & African Studies, University College London, University of Brighton International collaborators: University of Indonesia, National Institute of Nutrition, India. Université Cheikh Anta DIOP, Dakar, Senegal. Digital Green.
Impact Full funding for the GCRF Action Against Stunting Hub (MR/S01313X/1).
Start Year 2019
 
Description Global Challenges Research Fund International Collaboration using Epigenetics 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Member of a of a BBSRC led delegation to Nepal to develop UK-international collaboration in the area of nutrition and health. Our specific contribution was in the area of epigenetics and nutrition part of which was based on the methods and findings from this ESRC funded study. The discussions resulted in the preparation of a submission ("GCRF Action Against Stunting Hub") under the GCRF-Hub call. The hub was funded in 2019 and work has begun.
Collaborator Contribution This is a multi-disciplinary project in LMICs with each partner making a unique contribution. UK Collaborators: London Sch of Hygiene and Trop Medicine, MRC Unit, The Gambia, Liverpool School of Tropical, Int Livestock Research Institute Medicine, Royal Veterinary College, School of Oriental & African Studies, University College London, University of Brighton International collaborators: University of Indonesia, National Institute of Nutrition, India. Université Cheikh Anta DIOP, Dakar, Senegal. Digital Green.
Impact Full funding for the GCRF Action Against Stunting Hub (MR/S01313X/1).
Start Year 2019
 
Description Nutritional Intervention in Pregnant Adolescents in Bangladesh to Improve Cognition in mothers and offspring: a cluster-randomised controlled trial. (NIPA,B) 
Organisation International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)
Country Bangladesh 
Sector Public 
PI Contribution Our work on early life influences on long term cognitive outcomes through epigenetic mechanisms has led directly to this project which aims to study the same issues in Bangladesh using the epigenetic signatures identified in the course of this ESRC/BBSRC project. The project is under development with our collaborators in Bangladesh. If funded the project will study adolescents in rural Bangladesh.
Collaborator Contribution Our partners have developed the field work, cognitive and behavioural testing and nutritional supplements.
Impact Project under development.
Start Year 2019
 
Description ESRC Festival of Social Science 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Presentation on study aims and scientific and societal objectives as part of the ESRC Festival of Social Science (Aberdeen event) which was open to the public and was well attended.
Year(s) Of Engagement Activity 2018
 
Description Aberdeen Birth Cohort of 1936 reunion event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact A reunion event was held in August 2016 for members of the Aberdeen Birth Cohort of 1936 (ABC36). During the event, cohort members and their families were updated on recent results arising from the cohort data and of ongoing studies, including our current study using Next Generation Bisulphite Sequencing to extensively quantify methylation profiles in imprinted genes in DNA obtained from ABC participants (funded by grant ES/N00048X/I). The cohort members showed a keen interest when researchers got the chance to mingle and discuss studies over tea, coffee and cakes, and the researchers were rewarded with lively stories and fond memories from the past.
Year(s) Of Engagement Activity 2016
 
Description ESRC and BBSRC Epigenetics and Social Science Network inaugural meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The inaugural meeting of the ESRC/BBSRC biosocial epigenetics initiative was held in Bristol and attended by the groups participating in the programme. The aim of this meeting was to encourage cross-disciplinary collaboration and to promote a wider understanding of the programme and individual projects funded under this initiative. The aims and objectives of this project were presented to the wider research network.
Year(s) Of Engagement Activity 2015
URL https://app.researchfish.com/getform/0/dissemination-to-non-academic-audiences?action=add&zone=portf...
 
Description Epigenetics Showcase for stakeholders 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Third sector organisations
Results and Impact Epigenetics Showcase on the Thursday 2nd May 2019 (Church House, Westminster, London). Presentation based around the project outcomes and prospective directions for future research. Broad audience of stakeholders invited. The study PDRA also presented and discussed a poster describing key findings from the project.
Year(s) Of Engagement Activity 2019
URL https://bbsrc.ukri.org/news/events/2019/1905-epigenetics-showcase/
 
Description Member of Commissioning and Recommissioning Panel for ESRC/BBSRC Biosocial Centres for Doctoral Training 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact My work on this project was relevant to my appointment as BBSRC representative on the ESRC/BBSRC cross council initiative designed to bring together the social and biological sciences in the area of epigenetics. As part of this initiative I was also a member of the commissioning (and recommissioning) panel for the joint ESRC/BBSRC funded Biosocial Centres for Doctoral Training (CDT).
Year(s) Of Engagement Activity 2016,2020
 
Description Presentation at Aberdeen MayFest Public open doors event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Raising awareness of Biosocial research and its practical value.
Year(s) Of Engagement Activity 2018
 
Description Presentation at the 1st University of Indonesia SEAMEO International Conference on Food and Nutrition on World Food Day. The presentation was based on new paradigms and approaches to improving cognition though improving early life circumstances, citing the approach and findings of our ERSC funded study. The presentation was entitled; "A Whole Child Approach: The Importance of Early Life Adversity in Child Biology and Cognition". 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Presentation at the 1st University of Indonesia SEAMEO International Conference on Food and Nutrition on World Food Day. The presentation was based on new paradigms and approaches to improving cognition though improving early life circumstances, citing the approach and findings of our ERSC funded study. The presentation was entitled; "A Whole Child Approach: The Importance of Early Life Adversity in Child Biology and Cognition".
Year(s) Of Engagement Activity 2020
URL http://conference.ui.ac.id/seameo-recfon/ICFN2020
 
Description Presentation at the Houses of Parliament to the 'All Party Parliamentary Group for Africa'. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact In 2019 I gave a presentation at the Houses of Parliament to the 'All Party Parliamentary Group for Africa'. During the presentation on the proposed work of the UKRI/GCRF Action on Stunting Hub I described the study design and key results from the current project to explain the basis for, and rationale behind, the Stunting Hub. The goal of this Hub is to reduce child undernutrition and stunting through a better understanding of the complex interaction between biological, social, environmental and behavioural factors. This meeting was attended by DFID and other stakeholders, including NGOs.
Year(s) Of Engagement Activity 2017,2019
 
Description Presentation of the findings of the project to a meeting at WHO Geneva of the UKRI GCRF Hub (Action on Child Stunting) International Advisory Board 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Presentation of the findings of the project to a meeting at WHO Geneva of the UKRI GCRF Hub (Action on Child Stunting) International Advisory Board (see below). The presentation included a description of the way in which this project informed the Hub study design. The Board Members are:
? Prof Nicola Lowe, UCLan, GCRF Challenge Leader-Food Systems
? Dr Philip Woodgate, MRC Programme Manager for Global Health Challenge
? Prof David Nabarro, Imperial College London
? Dr Francesco Branco, Director Nutrition, WHO
? Prof Sandy Thomas, Director Global Panel
? Jocelyn Brown, Deputy Regional Representative for Africa at FAO
? Aparajita Ramakrishnan, Deputy Director, Donor and Government Relations, Gates Foundation
? Doddy Izwardi, Director of Nutrition of the Ministry of Health, Indonesia
? Dr Harshpal Singh Sachdev, Senior Consultant, Sitaram Bhartia Institute, India
? Prof Ibrahima Diagne, Coordinator, Albert- Royer National Children's Hospital, Senegal
? Abigail Perry, Senior Nutrition Adviser, DFID
? Prof Lucie Cluver, Principal Investigator for the UKRI GCRF Accelerating Achievement for Africa's Adolescents Hub
Year(s) Of Engagement Activity 2019
 
Description Presentation on "How Nutrition Improves Physical and Cognitive Health and Gender Equality." as part of an online webinar sponsored by '1000days' (a US NGO) 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Third sector organisations
Results and Impact Presentation on "How Nutrition Improves Physical and Cognitive Health and Gender Equality." as part of an online webinar sponsored by '1000days' (a US NGO) .

More than one billion women and girls around the world do not have access to the healthy diets they need to survive and thrive. Two thirds of countries report higher rates of food insecurity for women than for men. A variety of cultural, economic, biological, and structural barriers impede women and girls from accessing healthy, nutritious food. This webinar explored different perspectives on how nutrition can empower women. My presentation used the conceptual approach and findings of this ESRC funded project and proposed, on the basis of these, new perspectives on how to How improves physical and cognitive health through nutritional and other interventions in early life.
Year(s) Of Engagement Activity 2020
URL https://actionagainststunting.org/nourishing-gender-equality/