The role of phosphorylation in neurofilament function and dysfunction.
Lead Research Organisation:
King's College London
Department Name: Unlisted
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Ackerley S
(2004)
p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.
in Molecular and cellular neurosciences
Ackerley S
(2003)
Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments.
in The Journal of cell biology
Al-Chalabi A
(2003)
Neurofilaments and neurological disease.
in BioEssays : news and reviews in molecular, cellular and developmental biology
Angeletti B
(2005)
BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.
in The Journal of biological chemistry
Brownlees J
(2002)
Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport.
in Human molecular genetics
Chibalina MV
(2007)
Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment.
in Journal of cell science
Cullen VC
(2004)
Gigaxonin is associated with the Golgi and dimerises via its BTB domain.
in Neuroreport
De Vos KJ
(2008)
Role of axonal transport in neurodegenerative diseases.
in Annual review of neuroscience
De Vos KJ
(2007)
Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.
in Human molecular genetics
Kasher PR
(2009)
Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.
in Journal of neurochemistry
| Description | Axonal transport, protein trafficking and Alzheimerâ??s disease |
| Amount | £74,142 (GBP) |
| Funding ID | ART-PhD2006-2 |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2006 |
| End | 10/2009 |
| Description | CS -Wellcome Trust/MRC neurodegenerative diseases strategic award |
| Amount | £7,372,440 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2010 |
| End | 01/2015 |
| Description | MRC Programme Grant |
| Amount | £1,246,890 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2006 |
| End | 08/2014 |
| Description | Protein kinase-N (PKN) signalling and neurodegeneration in ALS. |
| Amount | £63,021 (GBP) |
| Organisation | Motor Neurone Disease Association (MND) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2004 |
| End | 09/2007 |
| Description | cdk5 signalling and disruption to the Golgi apparatus in amyotrophic lateral sclerosis |
| Amount | £73,868 (GBP) |
| Organisation | Motor Neurone Disease Association (MND) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2005 |
| End | 09/2009 |